Science topics: Medicine
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Questions related to Medicine
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117 answers
Many efforts are spent to prevent, treat and stop COVID-19 spread.
but I think these efforts are fragmentary and not organized.
there is no platform for a scientific collaboration that could shorten the time of interesting findings, some nations hide some facts are a privilege of authorship or for other political reasons.
I think that all countries should a global platform for scientific collaboration.
Personally I have some ideas that could be proposed for the treatment of COVID-19 based on scientific facts but with the innovative mode of application, how and where can I try to apply them?
All nations should avoid wasting their time to find a solution for COVID-19 without international collaboration.
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Thats a very good idea to unite and make joint efforts to defeat the pandemic the world is suffering.
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315 answers
Dear Fellows
With the developing stories of the spread of COVID-19 all around the world, which has been declared as a pandemic by WHO recently, I am wondering, in how much time this virus would vanish from the surface of the Earth? Is there any scientific study available for this?
Please share your opinions.
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Till development of an effective vaccine.
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44 answers
Hi,
I am conducting a research project to see whether demographic/patient factors can predict patients who are likely to suffer a post-operative death (Categorical outcome Y/N).
I have conducted univariate regression procedure using SPSS Firths regression as I have a small sample size with the dependant variable being a sparse event. This has given me 3-4 variables with P<0.10.
DO I now proceed to perform a multi-logistic regression? If so, do I run Firths regression with all of these variables selected as co-variates or do I perform a more traditional multi-nominal regression model instead?
Any help would be appreciated as I can't find any guidance on this issue.
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As your response variables are dichotomous, I suggest fitting both of multi-logistic regression and multi-nominal regression and then using AIC criterion to find the best subsets.
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135 answers
Hello!
I would like to understand in what cases blood or some other biological liquid passes through implant or graft with some porous microstructure according the Darcy law (thanks to the pressure differences).
I have an idea to produce a research about blood permeability through various implants microstructure, but unfortunately it is harder than I thought to found some justification in literature that blood actually could pass through such microstructure due the Darcy law. Thus, I would be grateful for your help in this question - maybe you have some papers about it or some other helpful stuff.
Sincerely, Catherine
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Thank you very much and I hope to recieve any updating about this flow
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56 answers
What do you have to say about another conference being promoted by " A. Siozos, M.D."?
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Hahahaha!
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84 answers
Ventilator is running out of supply under COVID-19, especially severely ill patients require non-invasive or even invasive ventilator support.
When there is outbreak of COVID-19 locally, physicians are facing the difficulties to choose between different patients for the allocation of limited medical resources.
Is there any simple way to turn something on hand to a usable ventilation machine? No matter household electronic gadgets, e.g. fan, vacuum cleaner, or existing medical equipment.
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Thanks Rajkumar for raising the pearls of the situation!
It is definitely a good summary of what we can do these days
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30 answers
I am involved in a post graduate programme in medicine. I observed but in all modules where self-directed learning has been applied, students are not progressing as expected. My thinking was may be our transition was not well done. Any input well-appreciated.
Regards
Prosper
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A very important question.
One way could be students themselves writing down (before study period starts) what they expect out of the opted course; what particular skills/area would they like to be proficient at; in short what exactly they wish to gain from the course. Teachers can then focus more on these areas; give case studies matching student interests and assessing on these areas of interest of the student. Once a student takes ownership and knows he can choose and focus on his area of interest as well; he will feel empowered and appropriately challenged at all times during his course. Chances of him/her getting de-motivated will, I strongly believe be reduced.
Best regards
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12 answers
till india is in second phase, as per world patient data india spreading rate is very low. but it may increase exponential. what you think about outbreak of corona virus in india.
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It is difficult to predict, but India is doing far better compared to other coronavirus (COVID-19) affected countries of the world.
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36 answers
Hi,
I am conducting a research project to see whether demographic/patient factors can predict patients who are likely to suffer a post-operative death (Categorical outcome Y/N).
I have conducted univariate regression procedure using SPSS Firths regression as I have a small sample size with the dependant variable being a sparse event. This has given me 3-4 variables with P<0.10.
DO I now proceed to perform a multi-logistic regression? If so, do I run Firths regression with all of these variables selected as co-variates or do I perform a more traditional multi-nominal regression model instead?
Any help would be appreciated as I can't find any guidance on this issue.
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Hello Suliman,
You didn't indicate how small a number the less-observed outcome was for your data set. If it's 100 or more, I wouldn't worry at all about using ordinary logistic regression. If 50-80, then LR may be fine if you have only a modest number of IVs in your model. If it's, say, 10 or fewer, then you're better off sticking with Firth method or some adjustment thereto (see link below). There are other, penalty-added methods available; I just don't know how they might perform with your data.
It's possible that someone has done a simulation study that includes conditions that match well to your data set. If not, you could always try that, to be more confident about your ultimate choice.
Good luck with your work.
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21 answers
Viruses can not be killed. If so does a person infected from CoViD-19 doesn't acts as a carrier after his cure?
That is if a person is infected with CoViD-19 and he is been cured by the medicine, does he has that virus in his body in deactivated form? Or the body kills the virus by phagocytosis by the WBC's?
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Please take a look at the following PDF attachment.
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150 answers
COVID-19 is affecting all kinds of human activities, research is not exempted. Many ongoing research studies are not paused because of COVID-19, patient recruitment cannot be continued, follow up visits are not stict to schedule, intervention procedures may be delayed, blood test monitor are postponed.
I would expect a higher loss to follow up rate during this period, which would affect the reliability of research. Even after COVID-19, will the recruited subjects have some difference than those recruited before?
What do you think?
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I am in a contiuous activities during this mandatory vacation but at home office..
Wish you all healthy life.
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240 answers
Describe impact of situation caused by pandemic of coronavirus COVID-19 on your Academic and Research activities.
Explain your action in a way to stay focused on Science and Preparing/Writhing/Publishing research.
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E learning (webinar, whatspp, Zoom, etc) is probably the way forward, but limited by internet availability (band width). Classical bedside clinics are irreplaceable, but out of place now. Simulation would be the answer for this, but planning a good simulation with limited resources is a challenge.
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25 answers
I ruminated a consideration on this proposal for the last couple of days as Germany is in anticipation of the surge.
To be clear: This is also just a theoretical exercise and – if applied - would count as a desperate measure in the case of patients otherwise not being ventilated at all.
What if the mode of ventilation chosen would not be conventional BIPAP but APRV/inverse ratio PCV?
The control parameters correspond to conventional ventilator settings as follows: P-high (P-insp), P-low (PEEP), T-high (insp. Time), T-low (exp. time) and FiO2. Note that implementing this mode of ventilation with conventional BIPAP, which is possible in some devices, will in some setups require calculation of respiratory rate, which is 60/(Thigh+Tlow). The slightly different terminology as well as specific algorithms for implementation have been characterized and properly published by experts in the field – which I am NOT. There have been promising studies in ARDS which I will attach below.
If one assumes that for two (or more) patients the key treatment goal would be oxygenation with a more liberal approach to CO2 removal, it should be possible to choose P-high, FiO2 and to some degree T-low to achieve safe oxygenation margins for both patients. This would still allow for some inhomogeneity in compliance between the patients as the lung is splinted to a rather high point in the P-V curve by P-high resulting in a high resting volume. This is the proposed “open-lung” aspect of this ventilation mode. Nevertheless, due to the sparse and brief passive pressure relief phases it is believed to go without higher frequency repeated expansion like in conventional PCV, resulting in less energy deposition into the tissue. The repeated overinflation/atelectasis due to inhomogeneos P-V dependencies had been my main concern when thinking about PCV in a shared circuit and a possible result of volutrauma/atelectotrauma in the patients.
In case of inhomogeneous severity between the patients/different disease progression the treatment goal could be set for the more severe patient accepting hyperoxia in the “more well” patient. In terms of CO2 removal a “common ground” target for the patients could be set in wider range of acceptable values, opting for permissive hypercapnia. As the passive release of the lung volume to exhalation in T-low will generate outflow which is cropped at a certain level of peak flow (by setting T-low) when conventionally setting up/adjusting this mode, it might be difficult to assess this control parameter for the individual patient in a shared circuit.
APRV does even allow for spontaneous breathing on P-high in weaning approaches which have been proposed as well. If flow for the device serving two patients would be dialed high enough to compensate for potential maximum inspiratory peak flow generated by both patients in spontaneous breathing, it could be fathomable to even conduct weaning with two spontaneously breathing patients sharing the same circuit.
I write this as I feel we are all staring in a potential abyss, which might force us to make choices that neither of us ever wanted to make.
Hence, this is a THEORETICAL CONSIDERATION and not a recommendation. Also I do not take any legal responsibility if patient harm ensues. I hope everybody understands that. Also probably someone already thought of this. But I thought: Sharing is caring.
Take care and stay strong.
C
Cane RD, Peruzzi WT, Shapiro BA. Airway pressure release ventilation in severe acute respiratory failure. Chest, Aug 1991: 100 (2); 460-3 Fergson ND, et al. High-frequency oscillation in early acute respiratory distress syndrome. New England Journal of Medicine 2013, 368 (9), 795-804 Frawley PM, Habashi NM. Airway pressure release ventilation: theory and practice. AACN Clinical Issues, 2001: 12 (2); 234-246 Garner W, Downs JB, Stock MC et al. Airway pressure release ventilation (APRV). A human trial. Chest, Oct 1988: 94 (4); 779-81 Habashi NM. Other approaches to open-lung ventilation: Airway pressure release ventilation. Crit Care Med 2005 Vol 33, No. 3 (suppl.) Maxwell RA, Green JM, Waldrop J et al. A randomized prospective trial of airway pressure release ventilation and low tidal volume ventilation in adult trauma patients with acute respiratory failure. The Journal of Trauma, Injury, Infection and Critical Care, 2010: 69; 501-511 Modrykamien A, Chatburn RL, Ashton RW. Airway pressure release ventilation: an alternative mode of mechanical ventilation in acute respiratory distress syndrome. Cleveland Clinic Journal of Medicine, 2011: 78 (2); 101-110 Rasanen J, Cane RD, Downs JB et al. Airway pressure release ventilation during acute lung injury: a prospective multicenter trial. Critical Care Medicine, Oct 1991: 19 (10); 1234-41 Roy S, et al. Early airway pressure release ventilation prevents ADRS – a novel preventative approach to lung injury. Shock 2013, 39 (1), 28-38
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The Society of Critical Care Medicine (SCCM) has provided guidance on treating two patients with a single ventilator.
Society of Critical Care Medicine. Working protocol for supporting two patients with a single ventilator. Society of Critical Care Medicine. 2020. https://www.gnyha.org/news/working-protocol-for-supporting-two-patients-with-a-single-ventilator/
Anaesthesia machines can also be used as ICU ventilators. The SCCM has also provided guidance on this.
Society of Critical Care Medicine. Purposing anesthesia machines for ventilators. Society of Critical Care Medicine, 2020. https://www.asahq.org/in-the-spotlight/coronavirus-covid-19-information/purposing-anesthesia-machines-for-ventilators
However it is not possible to deliver APRV via an anaesthesia machine.
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25 answers
Bickel (2009) describes those who remain robust under stress as resilient. Those who can rapidly adapt to change in times of stress are resilient. So, my question to you is, how are you? How are you coping? Are you thriving? Make sure you have seen this -> https://youtu.be/CCe5PaeAeew
Bickel, J. (2009). Faculty resilience and career development: Strategies for strengthening academic medicine. In Faculty Health in Academic Medicine (pp. 83-92). Humana Press.
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Poor communication with a new world called viruses, and not taking things seriously seriously with the influence of the media
Need music and some resitfor our brain far away Corona virous
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165 answers
Working in the research field, you will be weighted by your h-index.
However, publications might not be cited by others despite your hard work.
Do you think we should publish only citable research or publish as many as we could to contribute the academic field?
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Sunny Chi Lik Au I agree with Dean Whitehead (Citation isn't just a 'numbers game )
regards
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42 answers
The World Health Organization (WHO) defines traditional medicine as "the sum total of the knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical and mental illness". But some people believe traditional medicine is contrasted with scientific medicine.
What is your opinion? Can we use traditional medicine for treatment of COVID19? If your answer is yes, how do you want to do it?
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Is there an effective traditional medicine method in the treatment of COVID19? Is the effect of this method proven? I don't know. Only, they can have overall effects against infections.
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55 answers
Dear researchers
In your opinion, when is the peak number of cases of coronavirus disease (COVID-19)?
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15 answers
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Yes, smoke from the burning dried leaves of Calotropis procera is inhaled for the cure of cough and asthma.
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22 answers
Why is the INDIAN GRANATE used in medicine. Do you know which medicines?
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Momordica charantia has a number of purported uses including cancer prevention, treatment of diabetes, fever, HIV and AIDS, and infections. While it has shown some potential clinical activity in laboratory experiments, "further studies are required to recommend its use".
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42 answers
Does anyone know in which species the grass allergen Phl p5 occurs? It was originally isolated from the grass species Phleum pratense so it must at least occur in that species. It stand to reason that it might also occur in other species of the genus Phleum. A few papers states that it is universal in many grasses, but with poor documentation.
Can anyone provide conclusive evidence and/or references in which the authors state in which species (or cultivars) the allergen occurs and/or have been isolated from? I welcome answers from all researchers along with special interest from expert knowledge primarily from plant ecology, aerobiology, immunology and other health professionals.
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60 answers
Being invited to be reviewer for a conference or to be speaker is tempting for most young scientists. Not being aware of this businessplan I unfortunately accepted to review abstracts for one of such conference. Googleing around I realised I am not alone and that there are also several people wondering whether they should attend a conference or not as they are unsure if the organisers are genuine or not.
There are lists of predatory journals (e.g. https://predatoryjournals.com/journals/) but I did not find a good or comprehensive list of predatory conferences. So lets discuss such invitations to get a sense for those that can be trusted:
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Milena Cukic Publons needs to throw the predators out. Period.
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480 answers
I keep receiving e-mails from a "Dr. A Lesnevskyi M.D." from a so-called Internal Medicine Review journal. The journal has now several issues dating back March 2016. I checked the doi (digital object identifier) of some articles and most of them are not registered in Crossref. However, I was really surprised that a couple of articles were in Crossref. It is written in the website that they are indexed in Pubmed (National Library of Medicine (PubMed) ID: 101691967), but I was not able to find a single article there. Their ISSN numbers are fake, I was not able to find them in the ISSN portal (https://portal.issn.org/). A two story building at 712 H St NE Washington DC 20002 is the location of Gold Spot, a payday loan and check cashing business. The website uses the same fake address.
A little piece of advice if you are thinking in sending a polite reply that you are not interested: It is not a good idea to reply to any predatory publisher, even if it is to decline their offer or ask them to stop emailing you. They can then sell your email contact as a verified address to other publishers. Always block or mark as junk.
I wonder if all these "papers" published there are actual studies or fabricated texts only to embellish the website and attract more researchers willing to pay for a publication, with fees ranging from US$ 799 to US$ 2,999. For me this is clearly a predatory, fraudulent, fake journal.
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I have been receiving emails recently from L.Smith M.D. All his emails are very pushy. Thanks to all of you for discussing it here. He is in my spam list now.
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54 answers
I am facing a problem when I try to calculate the hr from two different survival curves, here is the problem: in the first plot the experimental group's curve is more close to the placebo group then the second plot, even if the first plot's hr is smaller than the second plot. I wonder what the possible reasons are. Can you guys help me to solve this problem? Thanks.
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It's hard to help without seeing the survival curves (Kaplan-Meier plot). Do you have one you can show us? Here's a video if you are not sure what I am talking about: https://www.youtube.com/watch?v=XDdytnv6HYE&list=PL64SCLAD3d1GJJrZ63sJGWALO22ZY9erG&index=27&t=1s
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9 answers
The presence of alloys and their use in medicine was one of the most important events and achievements in medicine. Do you think that the mechanism can change to amend this achievement?
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Thank you so much for prof Andrew Paul McKenzie
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3 answers
what should be the ratio of sodium benzoate in preparing a herbal suspension ?
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Ratio or concentration, what do you mean.
I think that the max concentration is dependant on the use, how much is taken per day and for how many days.
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45 answers
Are immunity enhancer medicine (Homeopathic and Ayurvedic ) helpful to prevent yourself from Corona virus?
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I do not believe that immunity enhancers will protect against COVID-19
But if you are in doubt about the full potence of your own immunity defense you could measure (or take reasonable amounts) of vit C, vit D, zinc and some others.
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210 answers
Dear Research Gate Members,
It has been observed worldwide that the individual with weak immune system can be easily attacked by Novel Corona Virus (COVID-19). The prominent health experts are also suggesting to improve immune system against Novel Corona Virus (COVID-19).
Please, share your expert suggestions on the following question.
How can we strengthen our immune system to fight against Novel Corona Virus (COVID-19) spread?
Thanks & Regards
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32 answers
How weather can be a factor in Corona virus spreading? As Africa is still safe from it.
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Good question. I think more data is needed to evaluate if and how weather is a factor in the spreading of COVID-19. On Africa it has confirmed cases in Egypt, Algeria, and Nigeria as of March 3, 2020... more countries may be confirmed in the future.
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100 answers
Dear Colleaugues,
There was a proposal of a researcher who asked me to write down a paper which will more or less extend the poster (link bellow) published at ICCB 2016 in Prague. This all happened by an accident. I did not like to come at a conference without some presentation. Hence, I did quickly put the ideas that are resonating in my head for years on that poster to allow other researchers to benefit from it. Surprisingly, this poster is getting a great deal of attention. Therefore, I am thinking about to write down a review (prescription) how to design sel-organizing and emergennt systems with a rich example aparatus. If you like the idea then wisit the poster and let there a comment about it (bellow the poster).
The whole project is meant as a service to the community of biological and medical researchers who would like to know more but have no time to study mathematics and programming in depth.
All the best at your research,
Jiri
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Thank you Mr.Jiří Kroc ,
We'll be in touch.
Kind regards,
Dragoljub Šarović
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45 answers
Deleted by Research Gate....
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I contacted RG support about that thread, and after a first email telling me how to report a thread or post, I told them that I was reporting THEM, RG, for removal of that discussion thread. This is what they wrote back:
Dear Randolph,
Thanks for the clarification. Please note that we may remove a question or discussion if there are any violations of our terms or guidelines. For privacy reasons, we cannot provide additional information regarding any actions taken in relation to other members' posts.
Kind regards,
Dan
RG Community Support
ResearchGate GmbH
Chausseestr. 20, 10115 Berlin, Germany
Only problem is, there are no terms of service against discussing the frauds and predators of the publishing/conference organizing world. All I can find is that outside the US, German laws prevail and Germany has some very outdated laws concerning "insults". The problem is, they have even clearer laws (Unfair Competition Act or UWG, and Telemedia or BSI Act) concerning the business practices of the fraudsters, as in all those unwanted emails we get sent that fraudulently claim presenters and sponsors, especially after telling the email spammers for years to cease and desist.
So KEI, like OMICS (which was fined $50million in the US for their fraudulent business practices), is violating Germany's UWG on a daily basis according to the various threads to date, and especially the one deleted. That deletion was particularly heinous in that it deleted the first hand experiences of people who had been to a predatory for-profit conference and gave details.
And again RG, I have been sent promotional material by KEI operatives trying to get me to sign up to speak at a KEI conference. In that promotional material sent by digital transmission, KEI claimed Keynote Presenters and speakers in their effort to get me to join. I have proof that at least three of those people were fraudulently listed to try to get me and others to sign up, were not attending and were unaware that their names were being published (digital media) as speakers for promotional purposes. As in, they never registered or agreed and yet KEI claimed them which is a violation of the UWG, at least three different paragraphs worth.
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27 answers
PPI affect CYP system while clopidogrel depend on this system to be converted to its active form. (controversy issue)
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Proton pump inhibitors (PPIs) inhibits enzyme CYP 2C19 interfering with the conversion of clopidogrel into its active metabolite. Studies document the possible interaction of clopidogrel and PPIs leading to a decrease in the antiplatelet efficacy of clopidogrel.
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345 answers
Dear Researchers,
The current Novel Coronavirus (SARS-CoV-2) epidemic in China has been declared an "Emergency of International Concern" by the World Health Organization (WHO). The number of SARS-CoV-2 cases are consistently increasing around the world. We are doing a survey on SARS-CoV-2 in health professionals to understand the existing knowledge gaps in the Novel coronavirus disease. Thus, we request your participation in this survey and provide your valuable opinion.
Kindly participate in the Survey: 
We value your input and thank you in advance for your participation!
Sincerely
Akshaya Bhagavathula
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75 answers
I am aware this is a rather odd question but I couldn’t find any answers to this in the literature. One study has used sperm cells as a drug delivery tool (see below) but I was wondering if it might have broader implications. Would sperm injected into the bloodstream survive for long? What about if it was taken orally? Would appreciate any thoughts!
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Sperm is typically prevented from exposure to blood - because even a male's own sperm is seen by their immune system as "foreign", leading to the formation of anti-sperm antibodies. This can be a problem in clinical situations such as after testicular trauma, leading to infertility.
As such, I dont think sperm delivery into the bloodstream is practical and although I dont have any specific data on it, I believe the survival of sperm in the blood stream would not be very long. The article you have linked to seems to be suggesting the utility of a sperm delivery system for anti-tumour therapy into the female genital tract (in the lumen, not via the bloodstream) to treat malignancies like endometrial cancer. I couldnt access the full text, so not sure how rigiriusly they have tested this - certainly sounds like an interesting idea!
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6 answers
A more advanced method of training would be to perform explosive medicine ball exercises after a weightlifting exercise, i.e. Cleans or Back Squats followed by a medicine ball vertical toss. This method of training is more commonly known as complex training
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I don't fully understand what's your question about and what do you mean by athletic power development? is it about development of peak power output in a sport specific movements? Proper, complex training involves a combination of high-loaded resistance exercise followed by a biomechanically similar explosive activity, best if specific for particular sport discipline. Therefore, medicine balls seems to be great equipment for use in this method since they allow to do ballistic movements (another great method for power development).
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There is a continuing accusation by alternative medicine practitioners that their method cannot be proven or their proof is inadequate. The basic principles, diagnostic, nomenclature and medical methods of Western and alternative (eastern) medicine are different. The western is linear and reductive, the eastern is more network-oriented. These require different methods of statistical analysis. Can they be judged by an approach?
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Yes, we always need to have the scientific research methods in mind but we need to be very wise while applying them, making sure the sistematic and Organization criteria are accomplished. That would be the only way to get consistent results and to measure the cost effectiveness of such a treatment.
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A milestone by Theodor Billroth in surgery and cancer surgery.
It is
- the 139th anniversary day (Jan 29, 1881)
Christian Albert Theodor Billroth (1829-1894)
performed
the first successful distal gastrectomy
for gastric cancer within 90 min
However, we may should be aware that everything in medicine surgery cancersurgery science needs teamwork
We are nothing without the Team!
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Theodor Bilroth performed the first Antral gastrectomy on a lady patient; The first successful after several attempts
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In a patient with hereditary desminopathy (Thr341Pro DES mutation in a heterozygous state) with disease progression, a significant decrease in olfaction is noted. How can this fact be explained?
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Could it be due to impaired ciliary motility leading to reduced beat and mucociliary conveyer mechanism
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I'm working on making new compound medicine, but I don't know how to evaluate the chemical interaction in lab environment (cristalization and other interactions) please help me. If you know a book or article can help me, I will be so grateful.
Thanks
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Sorry it is not my speciality
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Simple search in Google Scholar shows that since 1960-70 many articles in peer-reviewed journals have supported various desirable effects of Transcendental Meditation (TM) but some people here and there claim that the research has always bee. Funded by certain organizations and people who benefit from advertising TM and the published evidences are not so reliable. Is that really true?
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theoretical biology and medicine using artificial intelligence and mathematics is an emerging field in biology and medicine based on big data from bioinformation and healthcare electronic record. Clinical practice heavily relies on individual experiences, which lead to bias in recognition, diagnosis and treatment of disease. In fact, theoretical analysis is vital for biology and medicine. For example, chronic persistent inflammation plays an important role in carcinogenesis and also take effects on cancer metastasis. Under this theory, cancer patients with smoking have a high risk for lung metastasis because smoking can induce primary lung cancer occurrence through activation of chronic inflammation pathway. carcinogenesis. Further, it can be concluded that any stimuli induced persistent injury should be identified and avoided for cancer patients.
Dynamic monitoring of various bioinformation such as body fluids using physical and chemical methods is another emerging field in medicine. For example, urine is easy to be collected, which indicates many signs of various diseases. If the urinalysis by current advanced techonogies is cheap and convenient, it will be helpful to find potential diseases. They will give accelerated advancement in cancer metastasis research and other fields in medicine.
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Dear colleagues! Your opinion, please! What are the ways and opportunities for registering orphan drugs? Thank you in advance for the information. Best regards Olga Shnaybel
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Orphan drug. An orphan drug is a pharmaceutical agent developed to treat medical conditions which, because they are so rare, would not be profitable to produce without government assistance. The conditions are referred to as orphan diseases
Now an answer there are international rules that orphan drugs may just register, bu WHO.
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Can anybody help me to find out such website where i can find out solubility of any drug or medicine at one place?
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Pharmacopoeia
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I am a Brazilian psychiatrist with a master degree in preventive medicine. This year I will coordinate an academic ambulatory for medical students. I would like to teach deprescribing in psychiatry. The students are in the final year of medicine degree, and they will spend one month in this ambulatory. The ambulatory is part of a primary care setting which don’t have psychiatrists or other specialists. So, my major difficult is how to select patients? Which patients would benefit of this approach? Anyone has previous experience or suggestion??
Thank you!
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Cássio Henrique Gomide Papa - I recommend reading the presentation by Lia Dolovich, Pharm D on teaching deprescribing and also the references listed in her presentation.
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If the aim is to approach to the target. Why do we use "precision medicine" instead of "accurate medicine" ?
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It is not just about accuracy. Precision medicine is targeted, and tailored -on molecular level- for each patient.
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There are a lot of problems in medicine that needs the newest technologies in computer science fields like Machine Learning and Deep Learning to solve them.
Can anyone mention some of these problems that are unsolved till now?
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Let's start with a field that I know the best: biosignals processing, clarification, and prediction. There are many unresolved problems like
* Prediction of arrhythmias
* Prediction of epileptic seizures
* Reconstruction of physiological interdependencies of various physiological processes using biosignals.
* Reconstruction of physiological paths in the brain from biosignals.
* Assessing the health condition of people using biosignals.
We can do the following research
* Data mining for disease-genome dependencies from available databases.
* Prediction of disease spreads using internet searches.
* Assessment of the population health using internet searches.
* Cross AI methods with deep knowledge of complex systems theory and apply it to medicine -- this is my area of research.
* Study and predict drug interactions and side effects in patients. This will save a lot of unnecessary suffering in those using medical drugs.
* The above can be supported by an active search through all available data for possible, future drug interactions prior to their application to patients.
* Such research can help medical doctors to avoid deadly or highly damaging drug interactions. Each patient reacts differently to the same drugs! We need to know why and especially when it happens!
* Start development of advanced AI methods tailored towards the needs of bio-medicine.
All the above depends on how reliable databases of biosignals, medical records, bio-imaging, laboratory results, and many other database build.
When you want to have successful research in the field of AI, perfect databases that are open-access are a must. We have an extreme shortage of those databases. You can build a very successful carrier by building such a database(s). :-)
This is just a short list of all possibilities. :-)
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By the end of the year, what do you expect from your research field next year?
I look forward to excellent AI technologies and breakthroughs in the fields of literature, physics, mathematics, and medicine.
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Solving the environmental problems and find new solutions for detoxifying the Soil and waste water( recording my last achievements as patent too)!
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Medical History:
53 Y F, last degree prolapsed uterus presents with four ulcers, 2 on the surface of the uterus, one on the surface of cervix and another one (Can't recall the location). There is daily discharge. What is the appropriate treatment to eliminate the discharge until she undergoes vaginal hysterectomy? Local antibiotic therapy or what?
Medications she takes:
Bisoprolol 2.5 mg once daily for Atrial Fibrillation
Cetirizine 10 mg once daily for Allergic Rhinitis
Daflon 500 mg once daily for chronic venous insufficiency
Non-Alcoholic-Fatty liver disease (Not managed with medications)
Blood tests were done and no other abnormalities.
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Local estrogen cream until the ulcer heals then proceed to vaginal hysterectomy
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I recently attended an Education Conference where they encouraged teachers to use VR in their classes. In most of the cases these were medicine courses, but is it possible to incorate that technology in accounting courses?
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Glad I could help.
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The image shows surgical and gynaecological instruments used by ancient Egyptians over 3000-5000 years BC. It explains how advanced medicine at that time, scalpels, forceps, curettes were known and what we use as surgical instruments date back to ancient Egyptians designs. The question is, do you have a history of medicine in your medical/health curricula? What are the objectives of this component? And how do you integrate this part to other elements in the curriculum?
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Yes. It should be necessary to teach history in medical curriculum. It will be helpful to understand the concept and scope of medicine and surgical education.
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What shall be the choice: manual or automatic? It is clear from research and practice that inaccuracies exist with automatic BP use while manual seem preferable or yet not really? Some claim that automatic exclude bias in measurement.
Inaccurate reads of blood pressure lead to consumption of medications otherwise not needed if blood pressure measurements would be accurate. It affects lives-health. Which BP monitor shall be used? Both? How to resolve this dilemma in our age of automatisation?
I know that much inquiries are made by me but its a life related investigation.
Thank you in advance for contributions.
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Mirdamadi A, Etebari M. Comparison of manual versus automated blood pressure measurement in intensive care unit, coronary care unit, and emergency room. ARYA Atheroscler. 2017;13(1):29–34.
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The global average surface temperature rose 0.6 to 0.9 degrees Celsius (1.1 to 1.6° F) between 1906 and 2005, and the rate of temperature increase has nearly been doubled in the last 50 years. Temperatures are certain to go up further and may lead to fast genetic mutations in some pathogenic microbes to become accustomed to the new climate and proliferate resistant gene distribution over geographies. In addition, the overuses of antibiotics is also triggering the issues at a great step. Near about 10 most deadly bacterial pathogens have already been registered as antibiotic-resistant. Mycobacterium tuberculosis is one of them, that has already been created a huge challenge to overcome in their own right and will only become harder to control as their resistance to antibiotics grows. The development of new antibiotics is slow and difficult work but bacterial resistance is decreasing our arsenal of existing drugs posing a catastrophic threat as ordinary infections become untreatable.
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Addressing the global shortage of, and access to, medicines and vaccines
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Human body is full of spatial fractals and temporal bifurcations. During treatment in medicine ( ultrasound, X-rays, photons, neutrons, ions...) in computerized tomography ( CT) is used nonlinear or locally linear ( linearized) theory ? It is on-line or off-line in different cases?
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Computerized Tomography (CT) uses algebraic reconstruction technique (ART) which can be considered as an iterative solver of a system of linear equations. However, there exists nonlinear iterative algorithms for CT such as multiplicative algebraic reconstruction technique (MART) and experiments have shown that it can indeed further optimize CT algorithms resulting in greater image quality and dose reduction:
To answer your second question, it can be online, offline or even hybrid depending on the case.
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Is it possible to use a medical computed tomography (CT) machine for the inspection of 3D printed parts?
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Dear Masoud,
I think there is no problem in using CT for medical field. An industrial computed tomography (CT) scan can validate and qualify prototypes and the first printed parts for many different materials such as mold components, metal or plastic printed parts. Industrial CT scanning is able to validate internal geometry and defects within a part without destroying the part. From the two-dimensional X-ray images, the CT system is able to generate a 3D image for both the interior and exterior of the part. The 3D image may represent 3D volumetric density map in gray values based on the different composition of the sample.
CT-scan with 66 µm nominal voxel size can be useful to complaiance with X-Ray in diagnosing the Porosity analysis of 3D printed plastic parts. Decreasing the voxel size will improve the reliability of pore detection, but will also cost extra time and expenses for the CT-scan, reconstruction, evaluation and in storage. In particular, the X ray computed tomography (CT) inspection technologies show several advantages as a non-destructive method for acquiring structural characterization of both internal and external geometries of AM parts, and it might be the only available option to extract component dimensions of internal or hidden features that are inaccessible to well established metrology tools. This makes the CT technology a good partner in the “3D printing revolution” for the study and inspection of AM products. Of course, the ability of defect detection by X-ray CT has a direct correlation with the size, complexity, and type of material of the part being analyzed, but in principle high scanning resolutions are possible, from millimeters to micrometers, and more recently nanometers.
Please go through one of the references cited below.
Reference:
A. Thompson, L. Körner, N. Senin, S. Lawes, I. Maskery, R. Leach (2017): Measuremnet of internal surfaces of additively manufactured parts by X-ray computed tomography. Conference on Industrial Computed tomography 2017, Leuven/Belgium
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Which parts of Dinda are important from medicinal use point of view?
How that medicine extracted from same plant part.
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A patient with hereditary desminopathy (Thr341Pro DES mutation in a heterozygous state) was recommended to refuse toothpaste. He continued to brush his teeth twice a day with a toothbrush with only water. As a result, within one month we noted a significant increase in strength and muscle mass in this patient. The patient did not take any medications during this period. After 30 days, the muscle condition returned to its original level. How can this positive effect be explained?
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Another possible explanation would be that the patient's refrain from using the toothpaste lead to an increased level of plasma nitrate, which helped improve sympatholysis; thus, alleviating (possible) functional muscle ischaemia.
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Some may have normal iron level.
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Yes, we do it for confirmation.
In general
Daily iron and folic acid supplementation during pregnancy
Was
WHO recommendations
Daily oral iron and folic acid supplementation with 30 mg to 60 mg of elemental irona and 400 µg (0.4 mg) folic acidb is recommended for pregnant women to prevent maternal anaemia, puerperal sepsis, low birth weight, and preterm birth.
a The equivalent of 60 mg of elemental iron is 300 mg ferrous sulfate heptahydrate, 180 mg ferrous fumarate or 500 mg of ferrous gluconate. b Folic acid should be commenced as early as possible (ideally before conception) to prevent neural tube defects
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When will South America (or specifically Argentina) win a science Nobel Prize?
Another year without a Nobel Prize coming to South America
The last time that a South American scientist was awarded with a Nobel Prize was César Milstein, Physiology or Medicine, 1984. Are the richest countries rich because they inverts a lot in science? or they inverts a lot in science because they are rich?
The list is very short: Argentine 3, Brazil 1, Venezuela 1
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I think both of the things are right .Developed countries spends more on science to earn more from research and making their contribution well known in the world , so that they can sell their innovations and intervention to worldwide to earn a big sum over and again. As the says goes on , money attracts money $$!$
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Could we call published papers from all disciplines as SCIENTIFIC PAPER or just we say it for physics, biology, chemistry, mathematics, engineering, medicine or related things whereas linguistics or i.e. history is same?
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Dear Muhammad Shehryar Sabir, Mubasher Rehman, Thierry Olive thank you for your valuable answers, however, I meant that when you want to write a research in literature, history or education you need references, desk and possible questionnaire. Thus your research may not be similar to another in another place, but when there are scientific experiments which must be reproducible in other place in the world, therefore in the first case, it is a research study (research paper) while the second case is scientific research (scientific paper).
Best
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Hi, I attach an article on 'Milk Therapy' that has been recently published and you may be interested in knowing it. Best regards, Tomasz tomasz@plusultra.pl
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I hope this link may help you.
Best of luck. Thanks
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Medicinal values of age old Garlic is little known to us.Now it is time to bring awareness about the Garlic and how it can be used for health benefits. Valuable input requested from RG members.
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It is useful for treating infertility and reduce risk of cancer, useful for treating diabetes, migraine, stomach diseases, dermatology, hair strengthening, aging, dieting, teeth, to improve mood, for treating chest diseases and sore throat, eliminating harmful bacteria, fungi, etc
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Eating in illness
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Eating the right food serves as preventative medicine in times of health, and during illness serves still as medicine however needs will be different. Fasting is quite often the call with simple illnesses which if we deal with in the correct way then more serious illnesses should be kept away.
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The modern world is returning back to the nature! Organic/ Natural/ Unprocessed/ Wholemeal foods for good health, longevity - have become a craze now. But in case of treatment and prophylaxis - why do everyone opts for allopathic (the science based modern) medicine? Why not first the traditionals: Ayurveda/ Homeopathy/ Oriental/ Herbal/ Naturopathy/ Acupuncture/ Massage/ Yoga/ Dietary etc?
Aren't these scientific enough? Are they developing in appropriate pace with allopathy?
Why do modern clinicians still neglect/tease some of theses modes of therapies?
Why the new generation not getting solid confidence on these natural treatments?
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In rural and semi-urban India, traditional medicines are still the first option for treatment of diseases. People of all generations understand the importance of traditional medicines, that's why they are gradually shifting towards natural and plant based medicines as stated by Professor Amit Baran Sharangi Sir in his post.
Thanks!
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The involvement of excessive statistical terms made the Medical research difficult. A doctor remain most of the time busy in clinical practice. The involvement of unnecessary statistical tests and terms made research difficult for Doctors of Medicine. Moreover, it is experienced that Statisticians only keep the medical students confused in unnecessary formulas and terminologies but don't teach them the software like SPSS to evaluate their data their-selves. After cramming a lot of the statistical formula passing the subject of bio-statistics the student remain dependent on statistician for the analysis of data. Am I wrong? (it is my personal opinion)
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That's why the role of Bio/ medical statistician is important, as a good Biostatistician make it easy, and discusses in understandable language.
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What are the conceptual bases for personalised nutrition?
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A scientist job is very much energy consuming. Extensive work of Academic teaching, day to day designing new experiments, mentoring students and publishing research etc result in some serious health issues including stress, obesity, high BP etc. The food thy eat should also act as a medicine. So what are the best food supplements those must be used by scientists for the optimal performance during job.
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I agree with Mahendra Pal
Best Regards Mubarak Ali Khan
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Do you know any medicinal properties of chlorophyll?
Please share your ideas
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Photo-synthetic phosphorylation through PSI & PS II . It is a Mg - Porphyrin Che elate Complex or Called Antenna , absorbs Photon for the above light reaction
utilizing CO2 to synthesize carbohydrate & producing OXYGEN for our respiration .
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Anyone who expert in this topic...
It is expected that participants who will engage in medicine ball exercises will determine better performance in horizontal jumps. Participants who will not take part in medicine ball exercises will have trouble with horizontal jumps. Participants who will engage in medicine ball exercises will prove more explosive power and overall body strength which will improve their ability to make horizontal jumps.
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Can you please clarify which medicine ball exercises you are referring to?
The movement patterns, sets/reps and loads would all influence the transference to horizontal jump performance.
Thanks,
Matt Quittner
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Any suggestions please! !
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Hello,
Clinical audit is a quality improvement process that seeks to improve patient care and outcomes through systematic review of care against explicit criteria…Where indicated, changes are implemented…and further monitoring is used to confirm improvement in healthcare delivery.”
Principles for Best Practice in Clinical Audit (2002, NICE/CHI)
1. Clinical audit is not just a data collection exercise: • It involves measuring current patient care and outcomes against explicit audit criteria (also termed standards). • There is an expectation from the outset that practice will be improved.
2. Further clinical audit may be required to confirm that practice has improved. The main stages of the clinical audit process are:
1) Selecting a topic.
2) Agreeing standards of best practice (audit criteria).
3) Collecting data.
4) Analysing data against standards.
5) Feeding back results.
6) Discussing possible changes.
7) Implementing agreed changes.
8) Allowing time for changes to embed before re-auditing.
9) Collecting a second set of data.
10) Analysing the re-audit data.
11) Feeding back the re-audit results.
12) Discussing whether practice has improved
Some of the topics were below:
Further reading will be useful
I hope it will help
Regards
Mehul
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How could I possibly prepare 10, 25, 50 and 100 mg/ml solution from a 500mg medicine tablet of Mebendazole? Thanks for answering.
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Agreed with Saleh valuable suggestion.
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This because table sugar is extracted naturally from sugar cane or sugar beets and hydrolyzed to glucose and fructose and never could reach the body cells in its origin form. The hydrolysis process occurs in mouth, stomach and small intestine which the products of sucrose in body may be in a similar manner to that of honey and bread. In other words, sucrose is a carbohydrate that occurs naturally in every fruit and vegetable. But, why there is no similar propaganda to the not natural synthesized chemical candy such as aspartame and so on.
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Dear Dr Sameer M. Yassen
Thanks for your interesting answer. But you know the enzyme in slavia even could somewhat hydrolysis the carbohydrate of bread. Anyhow, western people were used to put a relatively big amount of sugar in there coffee and tea before second world war but then they reduced significantly even they drinking with no sugar but the ratio of cancer decreased due to that? Best regards
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In a patient with hereditary desminopathy (Thr341Pro DES mutation in the heterozygous state), a significant loss of muscle mass is observed after a night's sleep, with its replacement by adipose tissue. How to reduce muscle loss during sleep?
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Dear Ali Javadmanesh, Adrian Fierl, Abdulnabi Abdullamer Matruod, thank you very much for your answers!
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How good is empagliflozin for DM type 2? Is there any role of this medicine in primary prevention of CVD?
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There is a significant reduction of a primary CV endpoint with a glucose-lowering agent. In this study, the primary outcome (CV mortality, non-fatal myocardial infarction and non-fatal stroke) was reduced by empagliflozin compared with placebo. Empagliflozin also reduced all-cause mortality.
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Generally PH Level, TFM, Apart wish to have healthy discussion in the aspect of revealing what all are the major metric, Qualitative, Quantitative factor we need to consider in cosmetic products and research.
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Batchwise qualitative and quantitative assay of the ingredients mentioned or claimed is required. Besides skin compatibility and carcinogenicity should be checked as a part of R&D
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Is there any website that can tell me when this adverse reaction will occur? For example, will this adverse reaction occur after repeated exposure? Or can occur after first dose? Or can be delayed?
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Like some syrups, can tablets and capsules be flavor coated? Especially for children and adults who can't take regular tablets or capsules. Are there any side effects for flavor-coating a tablet or capsule? Besides masking taste of the medicine, can the smell of medicine be masked?
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Autopsies show that there are two abnormal structures in the brain with AD called plaques and tangles. Plaques are made from a protein known as Beta-amyloid and tangles are made of Tau protein. These proteins also exist in a healthy brain. What make them to lose their normal function and cause the cell death?
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more: to me, the question is "what makes some brain more resilient than others, bearing the same amount of toxic [misfolded] proteins ?"
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Why cant there be a journal dedicated to the field of medicine which does not yet have any experimental basis much like theoretical medicine?
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In most contexts, the terms alternative medicine, complementary medicine, integrative medicine, holistic medicine, natural medicine, and unconventional medicine are almost synonymous.
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Everyday more patients seek non conventional approaches to their non resolved medical problems. Many of these approaches are safe and recommended by credited physicians. At the same time, conventional medicine discredits this therapies because of lack of demonstrative clinical studies.
I believe many non conventional therapies should be includes after judicious consideration, and serious clinical studies should be performed when a positive balance between (good) efficacy and (low) risk is perceived.
In this way, many today’s innocuous, non conventional therapies could precede more aggressive mainstream therapeutical approaches.
Two main factual problems should be taken in consideration:
First the lack of clinical studies comes from huge imbalance between private pharmaceutical funding and that of non conventional therapies. This brings up the ethical question: Is clinical research really at patient´s service or at the service of pharmacology?
Secondly, I believe that not only "scientifically" proven medicine acceptable. Good clinical sense should always come first, based when necessary but never exclusively on clinical studies. In this sense, we must remember that most of our conventional practice is based on "accepted" opinions and not in the so called "science”. Many of the cases because of obvious reasons ... nobody is refraining from performing CPR to a arrested patient, or ventilate a patient in critical respiratory failure just because no randomized, double blind, controlled studies were made to demonstrate its efficacy in that particular situation.
As a consequence my position is to approach non conventional medicines as an opportunity rather than as a problem.
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Many studies reported an association between nutrition and human hearing loss. These studies showed the incidence of hearing loss was increased with the lack of micro-nutrients such as vitamins A, B, C, E, zinc, magnesium, selenium and iron.Moreover, high carbohydrate, fat, and cholesterol intake, or lower protein intake, are responsible for poor hearing status.
Dear colleagues, Any more studies or experience about the relation between nutrition and hearing loss?
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I think the following article will be useful
Best Regards Wesam Salah Ibrahim
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Helicobacter pylori inhabit the gastrointestinal tract, one person’s poison may be another’s cure. Helicobacter pylori, the bacterium that causes gastric ulcers and stomach cancer in some people, may actually protect against cancer of the esophagus. So, What about your experience in the paradoxical effect of Helicobacter pylori infection? and why their resistance to treatment was increased?
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I have no experience in this field, but i think the following article will be helpful
Best Regards Wesam Salah Ibrahim
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What is fitness definition in your opinion ?
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Fitness is the ability to do daily tasks without fatigue
Best Regards Wesam Salah Ibrahim
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Coffee is a simple beverage, but it’s full of complex compounds with health benefits. It contains hundreds of bioactive components including vitamins, minerals, and anti-inflammatory polyphenols such as flavonoids. The amount of caffeine in a cup of coffee can vary, depending on factors ranging from the type of bean used. So, What about the healthy daily amount of caffeine was recommended to be healthy with no risk?
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Every athlete requires an adequate amount of protein. It’s not only good to increase lean muscle mass , it will also optimize anabolic hormone levels, increase metabolism relative to other nutrients and improve cardiovascular risk profiles.
So which are better protein supplements or protein in foods ?
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There are seven types shown in the following link
Best Regards Wesam Salah Ibrahim
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Will nanotechnology solve the world problems such as water purification problem and delivery of medicine?
What about of its health and dangerous effects? How can nanotechnology domain with these potential effects?
Thanks
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Everything which is powerful has the risk to be dangerous, also it (nanotech) is slow paced. People may have sparkling word for the bright future or so, but we should realistically understand what we actually do, what our mentality is and what we are capable of. Nanotechnology will improve certain domain like water purification, delivery of medicine, that's the specialty of nanotechnology. But until or unless if u r not strong in any other domain its waste of choosing this. Nanotechnology alone won’t work; it’s all about application where u use it.
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When dealing with isolated conditions or common condition with rare presentation, case reports are practically helpful than any other studies.individual case reports will lead us to precision medicine.
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Yes, Monika Pathania I agree, if the case report covers a relatively rare condition / rare presentation. It may be possible to find other cases also reported singly; this then enables the reader to compare / contrast. But if the case reports were not published, this could not take place. In this way, the scientific community are enabling a larger picture to be shown.
This is relevant:
These are papers by ResearchGate members around this topic:
Nakamura, T., Igarashi, H., Ito, T., & Jensen, R. T. (2014). Important of case-reports/series, in rare diseases: using neuroendocrine tumors as an example. World Journal of Clinical Cases: WJCC, 2(11), 608.
Gagne, J. J., Thompson, L., O’Keefe, K., & Kesselheim, A. S. (2014). Innovative research methods for studying treatments for rare diseases: methodological review. Bmj, 349, g6802.
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Is it a trip to the moon, a discovery of electricity, an Internet discovery, achievements in medicine, biology, psychology, astronomy, IT-technologies, electronics, finding printing, engine, aircraft, etc.?
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All are important , but I think that discovery of electricity is the most important , because all of them depends on electricity .
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Please let me know that is there a complete and successful treatment of Vitiligo invented scientifically? A treatment which people can use to save their skin from a white dots and patches? If no, then anyone who has a project on inventing a medicine for treatment?
Some pictures has been added for the examples of Vitiligo.
- Muhammad Sinan
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Dear Md. Sinan, I have already invented the most easy and perfect method to "CORRECT" Vitiligo changes and my classmates who are Dermatologist are in the way to make it a success, already 90% of the work is over and the launch is in India - State called Karnataka and The city called Bangalore.
I would like to explain my invention as follows:-
  1. Vitiligo is not a disease but progressive discoloration of the skin due to loss of melanin pigment.
  2. With the help of human body scanning software (company involved is not mentioned) the individual body is scanned part by part and further next step is continued - eg:- Dorsum of hand - is scanned and stored.
  3. The common color of the skin of the individual skin is scanned and the color is chosen for mixing the Biological Dye.
  4. Skin surface is anesthetized mostly locally or by G A if ever necessary than the computer programmed surface "TATTOO" is done with extremely special needles which are designed for superfine sub dermal dye impregnation.
  5. A total controlled "ASEPTIC" precaution is to be observed.
  6. keep tattooing as the the patch spreads and it has to eventually stop and you can live with the permanent tattooing procedure for the rest of your life.
  7. Any part of the body is possible including "upper eyelid" with thin ceramic orbital plate inside the eyelid and very special short length needles are used.
  8. soon the whole world can benefit by this method which is harmless and life time permanent correction
  • hope you liked it.
  • Thanks for your time to read it
  • (since it is a "Intellectual Property and on Patent I could not say more than this).
  • I selling this technology to any body who would want to purchase this intellectual property.
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Does anyone have soft copy of book "Epidemiology of Medicine" by Henneken. Please share.
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Hey many thanks :)
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Is anybody aware of documented sources on Traditional Fijian Medicine and Midwifery?
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Please see
-Singh YN. Traditional medicine in Fiji: some herbal folk cures used by Fiji Indians. J Ethnopharmacol 1986;15(1):57-88.
-Chand R et al., Traditional use of medicinal plants among selected villages in Fiji islands: A review perspective - Pacific Medical Student Journal 2018, https://www.researchgate.net/publication/327514571_Traditional_use_of_Medicinal_plants_among_selected_Villages_in_Fiji_Islands_A_Review_Perspective_-_Pacific_Medical_Student_Journal
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Applications of bioinformatics in medicine is a key factor in technological advancement in the field of modern medical technologies.
In which areas of medical technology are the technological achievements of bioinformatics used?
What are the applications of bioinformatics in medicine?
Please reply
I invite you to the discussion
Thank you very much
Best wishes
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Precision Medicine, Genomics and associated fields. Smart and precise clinical decision support relies on reliable analysis of actionable and harmonized bioinformatics.
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Homeopathy has a long history and relaid on utilization of natural substances to cure diseases without performing any modifications of body parts as done in Allopathy.
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Homeopathy has a long history as you mentioned and as a holistic medicine in many treatments work and heal .
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Virus is living only inside living host whereas outside the host , it remains inactive but not dead
Chemically it is a protein in combination with DNA or RNA
Can it be possible to destroy or kill it by proteolytic enzyme or any other relevant chemical
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Most viruses (if I'm not wrong) do not "live" long outside the host, and most require close contact to transfer or direct contact of bodily fluids. So in the environment, bleach or alcohol (water/soap) is enough to "kill" them.
And inside the host but outside cells... I'm pretty sure there is enough immune response to remove them.
As for the question...well... you do have to get pass the viral capsule first. And there is nothing specific about proteolytic enzymes or DNAse/RNAse that would only target the virus and not host cells.
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1. En dientes anteriores superiores e inferiores de canino a canino.
R:
2. En dientes premolares superiores e inferiores.
R:
3. En molares superiores e inferiores.
R:
4. El costo del tratamiento incluye la consulta médica?
R:
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U$ 100 para anteriores, 150 premolares y entre 80 y 200 en molares. No incluye la consulta que serían 30/40 dólares.
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In this article, I like that Dave raises the huge issues we face in using exercise as medicine. In fact the American College of Sports Medicine have the mantra that "exercise is medicine", something we would do well to keep in mind.
My question is this: In the main GPs have a great deal of work to do in order to fully understand the benefits of exercise, but are they really the right people to prescribe it?
In the UK we have a great deal of very well qualified and competent graduates from sport and exercise science related degree programmes who can provide this sort of expertise in the prescription of exercise for all manner of populations that is based on an evidence base. These graduates have good knowledge of exercise physiology, psychology and other related exercise topics and could provide an invaluable service to our wider community.
In other words, education of GPs in the benefits of exercise is critical, but the people to deliver this service are already there and perhaps there should be efforts made to recognise the skills and knowledge that is at our fingertips. One potential scenario is that a small group of exercise specialists could be part of every practice and therefore embedded in to our primary care.
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Only if they are fit.
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I want to know how widely such new drug as trehalose (approved by FDA) is used in practical medicine for example for treatment of neurodegeneration. Majority of trials with it seems to be without definite answer.
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Trehalose is of particular interest having been shown to reduce protein aggregates in models of other neurodegenerative diseases (Tanaka et al., 2004; Davies et al., 2006). Trehalose is a naturally occurring disaccharide, which appears to play an important role in stress responses in yeast (Singer and Lindquist, 1998). Whilst it has been suggested that its ability to reduce protein aggregation occurs due to a chaperone activity, or through binding and stabilization of abnormal proteins (Tanaka et al., 2004; Davies et al., 2006), it has also been shown to act via an mTOR-independent pathway to increase autophagy (Sarkar et al., 2007; Rodríguez-Navarro et al., 2010). These studies have clearly prompted interest in this compound, though a recent study of mouse primary cortical neurons found that trehalose did not prevent toxicity from exposure to α-synuclein pre-formed fibrils (Redmann et al., 2017).
Mini Review ARTICLE Front. Neurosci., 08 October 2018 | https://doi.org/10.3389/fnins.2018.00693 Emerging Treatment Approaches for Parkinson’s Disease Thomas B. Stoker1,2,3*†, Kelli M. Torsney1,4† and Roger A. Barker1,2,3
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Robot passes medical exam and become a doctor in medicine.
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