Medicine - Science topic

Dear Dr Sunny Chi Lik Au . See the following useful RG link:

Dear Eleas,

If I understand correctly your question is with respect to the chemical reactivity of an NCE for its target.

Most commonly high chemical reactivity is not seen as an advantage. First the molecule needs sufficient stability for shelf life, limit impurities... Then reactivity may lead to safety issues if this leads to reaction with proteins other than your intended target. A variation on this theme is also formation of reactive metabolites that can cause liver toxicity; this is linked to the original molecule having reactive features or groups that are made reactive when oxidized (oxygenated).

However, reactivity towards the intended target can be very effective for inhibition from covalent binding. This can for example allow to decuple PK and PD (prolonged PD depending on target turn-over). For this to be effective it needs to be specific: reactive "warhead" reacts only with the intended target when molecule specifically bound and not with relevant off-targets. An example of this you can read about is remibrutinib.

In India the most powerful and fatal variant inspite of complete Covid vaccination . Delhi and West Bengal are already suffering lockdown under disaster management act .

https://www.cdc.gov/coronavirus/2019-ncov/variants/omicron-variant.html#:~:text=The%20Omicron%20variant%20likely%20will,or%20don't%20have%20symptoms.

EVIDENCE

And Epigenetics

Evidence:

Hafiza Muriam Ghani Could you please share your email and message me?

@ Anwar, TiO2 nanoparticles is an effective microbicide agents, which have the advantage of improved safety and stability compared to organic antimicrobial agents. Titanium dioxide is also used in most sunscreens to block UVA and UVB rays. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups.

Check https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555946/

Resistant exercises can tire MS disease quickly. This is an undesirable situation in patients with MS.

I recommend more ROM exercises and short-term isometric exercises.

Also check..

This depend on the drug bioavailability , way of excretion may be differ than that in animals all these should be taken in consideration

check this

Publishing on a particular area does not require one to necessarily have a certificate in that area. However, if you find yourself to be inadequately equipped with the requisite knowledge to do a good job in that specific field, you may overcome that by collaborating with someone with that knowledge so that together you can bring out a very good and scientific work.

Former USSR traditional lecturers with great academicians, undoubtedly those times won't be repeated anywhere, Prof. Henrik G.S. Arvidsson

The best MS exercises are aerobic exercises, stretching, and progressive strength training. Aerobic exercise is any activity that increases your heart rate, like walking, jogging, or swimming. You just don't want to overdo it—it should be done at a moderate level. https://www.pennmedicine.org/updates/blogs/neuroscience-blog/2017/may/multiple-sclerosis-and-exercise

The change in the level of uric acid and biochemical parameters in a patient with an identified case of desminopathy is presented in the article https://www.researchgate.net/publication/357311034_CHANGE_IN_REDOX_STATUS_AND_BIOCHEMICAL_PARAMETERS_IN_PATIENT_WITH_DESMINOPATHY_T341P_SEVERAL_YEARS_AFTER_DISEASE_SYMPTOMS_ONSET

Have a look at this useful RG link.

Hello. This topic is not exactly my field, so I cannot give you a satisfactory answer. I will be happy to follow all the news and discussions in this field.

Regards, Zlata Felc.

Hello V.L.B. De Mel

Please refer to the article attached. It may be helpful.

Best.

Please see these links for info on health and consequences of COVID-19 for people with disabilities:

Hi Liliana,

Yes, you are right. There is a plenty of discussion in this area. Please find below some guidelines.

There are four legal elements which must be proven: a professional duty owed to the patient; breach of such duty; injury caused by the breach; and (4) resulting damages.

In general, malpractice claims are adjudicated in state courts according to laws (e.g., USA), which typically require three elements for a successful claim: the patient suffered an adverse event; the provider caused the event due to action or inaction; and 3) the provider was negligent, which essentially entails showing that the provider took less care than that which is customarily practiced by the average member of the profession in good standing, given the circumstances of the doctor and the patient. Collectively, this three-part test of the validity of a malpractice claim is known as the “negligence rule.” In theory, this rule should provide compensation to iatrogenically injured patients and lead doctors to take appropriate precautions against accidental harm. In practice, however, the rule performs poorly on both dimensions.

Dear Rafi Al-Ani Do have a look at the following discussion here on RG: https://www.researchgate.net/post/Beware_of_these_kinds_of_emails

Conclusion: avoid.

Best regards.

please eloborate what you mean by bloodlessness ? If you are talking about anemia, then a balanced diet and vitamin supplements are needed.

(only one point). maybe there is a difference to state how the image was made and how the scale could be, even though the scale bar is almost approximately at the same level each time. STM, (scanneling Tuning Microscope, false colour, the blacvk and white images, maybe the microscope taken with this 10x, objectives, and so on.All these give ideas on how the scale bars are.... even though I think it is ignored data.

Have a look at this useful link.

You can publish your study protocols in any of the journals which has scope of your title. Example: BMC, BMJ Open, Clinical Trials,… etc.

Please have look on our(Eminent Biosciences (EMBS)) collaborations.. and let me know if interested to associate with us

Here is our lab page: https://www.eminentbio.com/home/members

Here is our publication: https://www.eminentbio.com/home/Publication

Our recent publications In collaborations with industries and academia in India and world wide.

Our Lab EMBS's Publication In collaboration with Universidad Tecnológica Metropolitana, Santiago, Chile. Publication Link: https://pubmed.ncbi.nlm.nih.gov/33397265/

Our Lab EMBS's Publication In collaboration with Moscow State University , Russia. Publication Link: https://pubmed.ncbi.nlm.nih.gov/32967475/

Our Lab EMBS's Publication In collaboration with Icahn Institute of Genomics and Multiscale Biology,, Mount Sinai Health System, Manhattan, NY, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918

Our Lab EMBS's Publication In collaboration with University of Missouri, St. Louis, MO, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30457050

Our Lab EMBS's Publication In collaboration with Virginia Commonwealth University, Richmond, Virginia, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211

Our Lab EMBS's Publication In collaboration with ICMR- NIN(National Institute of Nutrition), Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/23030611

Our Lab EMBS's Publication In collaboration with University of Minnesota Duluth, Duluth MN 55811 USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211

Our Lab EMBS's Publication In collaboration with University of Yaounde I, PO Box 812, Yaoundé, Cameroon. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30950335

Our Lab EMBS's Publication In collaboration with Federal University of Paraíba, João Pessoa, PB, Brazil. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30693065

Our Lab EMBS's Publication In collaboration with collaboration with University of Yaoundé I, Yaoundé, Cameroon. Publication Link: https://pubmed.ncbi.nlm.nih.gov/31210847/

Our Lab EMBS's Publication In collaboration with University of the Basque Country UPV/EHU, 48080, Leioa, Spain. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852204

Our Lab EMBS's Publication In collaboration with King Saud University, Riyadh, Saudi Arabia. Publication Link: http://www.eurekaselect.com/135585

Our Lab EMBS's Publication In collaboration with NIPER , Hyderabad, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29053759

Our Lab EMBS's Publication In collaboration with Alagappa University, Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30950335

Our Lab EMBS's Publication In collaboration with Jawaharlal Nehru Technological University, Hyderabad , India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/28472910

Our Lab EMBS's Publication In collaboration with C.S.I.R – CRISAT, Karaikudi, Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237676

Our Lab EMBS's Publication In collaboration with Karpagam academy of higher education, Eachinary, Coimbatore , Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237672

Our Lab EMBS's Publication In collaboration with Ballets Olaeta Kalea, 4, 48014 Bilbao, Bizkaia, Spain. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918

Our Lab EMBS's Publication In collaboration with Hospital for Genetic Diseases, Osmania University, Hyderabad - 500 016, Telangana, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/28472910

Our Lab EMBS's Publication In collaboration with School of Ocean Science and Technology, Kerala University of Fisheries and Ocean Studies, Panangad-682 506, Cochin, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27964704

Our Lab EMBS's Publication In collaboration with CODEWEL Nireekshana-ACET, Hyderabad, Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/26770024

Our Lab EMBS's Publication In collaboration with Bharathiyar University, Coimbatore-641046, Tamilnadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27919211

Our Lab EMBS's Publication In collaboration with LPU University, Phagwara, Punjab, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/31030499

Our Lab EMBS's Publication In collaboration with Department of Bioinformatics, Kerala University, Kerala. Publication Link: http://www.eurekaselect.com/135585

Our Lab EMBS's Publication In collaboration with Gandhi Medical College and Osmania Medical College, Hyderabad 500 038, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27450915

Our Lab EMBS's Publication In collaboration with National College (Affiliated to Bharathidasan University), Tiruchirapalli, 620 001 Tamil Nadu, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27266485

Our Lab EMBS's Publication In collaboration with University of Calicut - 673635, Kerala, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/23030611

Our Lab EMBS's Publication In collaboration with NIPER, Hyderabad, India. ) Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29053759

Our Lab EMBS's Publication In collaboration with King George's Medical University, (Erstwhile C.S.M. Medical University), Lucknow-226 003, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25579575

Our Lab EMBS's Publication In collaboration with School of Chemical & Biotechnology, SASTRA University, Thanjavur, India Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25579569

Our Lab EMBS's Publication In collaboration with Safi center for scientific research, Malappuram, Kerala, India. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30237672

Our Lab EMBS's Publication In collaboration with Dept of Genetics, Osmania University, Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/25248957

Our Lab EMBS's Publication In collaboration with Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/26229292

Sincerely,

Dr. Anuraj Nayarisseri

Principal Scientist & Director,

Eminent Biosciences.

Mob :+91 97522 95342

Dear Pr Brücher,

Thank you for sharing with us these useful informations.

Best regards,

Pr Hambaba

Please go through the following RG links.

The SARS-CoV-2 (Covid-19) coronavirus pandemic is a global epidemic. On a global scale, the state of the pandemic in March 2020 was announced by the World Health Organization. Therefore, this organization could declare the end of the pandemic. On the other hand, the end of the epidemic on a regional, national or local scale can be announced by national central institutions of the health care system, including the ministries of health, in agreement with the government. In order to be able to declare the end of the epidemic on a national, regional or local scale, it is necessary to have a relatively large decrease in the number of new coronavirus infections, a decrease in the number of people seriously ill with Covid-19 disease and deaths caused by this disease. The decrease in Coronavirus infections and in sick people should be sustained in a longer period, i.e. min. several months, taking into account the periods of possible occurrence of subsequent epidemic waves caused by new variants of the Coronavirus and occurring in other regions of the world. In addition, an important factor that may be taken into account in the event of declaring the end of a pandemic on a global scale or an epidemic on a regional scale will be the level of vaccination of citizens with highly effective vaccines against Coronavirus and the level of social, collective immunity of the society achieved thanks to these vaccines.

Best regards,

Dariusz Prokopowicz

Hi Dr Swayamprakash Patel . I hope the following link could help:

I think depends on

1. Quality of Journal which depends on citations, Quartile, Indexing, Impact Factor etc.

2. Novelty

Regards

I think this will help

Thanks you, dear Dr.Mark Louis Weiss

dentistry needs only few drugs to be remembered, procedures like extractions and root canal need common antibiotics, to follow empirical use pls know few gram positive acting drugs and some mixed infection drugs, we use anti amoebic drugs as well. anti- inflammatory and analgesics are routinely used, need to remember few of it. Beware of drug interactions especially metronidazole should not be taken along with alcohol

some emergency drugs like hematinics, to stop bleeding and anti allergic drugs should be learned

for oral lesions need to know about anti oxidants, and few local steroids ointments, some gum paints and aesthetic gels for pain relief

as a beginner if you know these you get confidence

Check https://www.lesker.com/materials-division.cfm?section=evaporation-materials

Interesting

CDC considers a person to have a fever when he or she has a measured temperature of 100.4° F (38° C) or greater, or feels warm to the touch, or gives a history of feeling feverish.

https://www.cdc.gov/quarantine/air/reporting-deaths-illness/definitions-symptoms-reportable-illnesses.html#:~:text=CDC%20considers%20a%20person%20to,history%20of%20feeling%20feverish.

With Regenerative Medicine, using stem cells, the ongoing Programs are doing it, with good results and promising expectations.

Dear Roy Bagus Kurniawan

I'm assuming the pairs have correlation coefficient >= 0.7 (r=0.07 suggests little correlation).

If you have 3 distinct pairs, I would suggest eliminating one variable from each pair leaving the most significant ones in the set. After that, you can proceed with a stepwise regression, if needed.

Another possible solution would be implementing a dimension reduction technique (i.e. principal component analysis) to reduce the number of predicting factors.

If you require any further information, let me know.

Best wishes,

Francesco

Todavía no se puede predecir q desaparecerá el Covid 19. Al parecer tendremos q convivir con él e inmunizarnos con las vacunas aprobadas por la OMS.

Please also have a look at this useful link.

Some references-

DOI: 10.1016/S2222-1808(12)60173-X

Ringworm is a Hard Cycle to Break - DTN/Progressive Farmer

Theoretically yes, but in the long run the human species would end up adapting its immune defense mechanisms and would survive ... yes, the cost in human lives would be incalculable in the short and medium term

I think it is not mendatory and I agree with @Shin Murakami

Studies providing the evidence of MSG toxic effects have raised the increasing interest in MSG intake as flavor enhancer. Neurotoxic effects in brain, obesity and metabolic defects, „Chinese restaurant syndrome“ and detrimental effects on sex organs are the most discussed in the connection with MSG intake. http://ibimapublishing.com/articles/JMED/2013/608765/

I Follow.

https://www.mdpi.com › pdfPDF

Sentimental Analysis of COVID-19 Tweets Using Deep ... - MDPI

I don't think there would be a generic tutorial for analysing a EHR, they are all different and the software should provide help on how to search a topic. Unfortunately coding classifications systems are different across the world and within countries. See that there is considerbale variation of coding and quality. Not even HL7 is uniformly applied in the UK as a health data standard https://en.wikipedia.org/wiki/Health_Level_7 It's a difficult problem.

Co-authorship is not a form of reimbursement (in laboratories and research institutes, all co-authors receive a salary or grants, nevertheless...). If a persons has made a creative contributions, then they are a co-authors. If the work is technical - for example, reprinting a text, or measurements (without processing etc.), then - no. There is another form for highline such participation: acknowledgment.

Efficiency, efficacy and effectiveness: What is the difference between this triad of words? Peter Drucker - considered the father of modern administration - establishes a series of fundamental distinctions between them, which gives us conceptual clarity. In a colloquial way they are known as "The three E's", but how does one "E" differ from the other two; Drucker is obliged to quote again, with the appearance of what he called “knowledge work”, thus we have: Efficacy + Efficiency = Effectiveness

Efficiency: doing things well. Carry out a task looking for the best possible relationship between the resources used and the results obtained. Efficiency has to do with the "how." The model for improving efficiency is based on three basic pillars: people, processes and customers. And it is achieved with competent people or with capacities, attitudes, aptitudes, abilities and experiences. Fast, effective and continuous flows of activities are needed that add value to the product or service for the client with efficient processes, analyzing said activities and quality.

Efficacy: doing the right things; carry out tasks in the best way, leading to the achievement of results. It has to do with "what" things are done. Effectiveness is doing what is necessary to achieve or achieve the desired or proposed objectives.

Effectiveness: doing the right things well. In other words, the tasks that are carried out are carried out efficiently and effectively. It has to do with "what" things are done and "how."

Ashwin Chandra Chiluveri

Sir! in the ayurvedic text a wide description is available related to curd. use of curd in relation to seasons when to eat or when not to eat. it is also described when to eat on daily basis, with the mixing of other substances. these all are for healthy individuals.

in some cases it is contraindicated because of its property.,

I don't think such a huge description will be available in other traditional medicines.

Have a look at the following RG links.

Globally, Candida albicans is the most prevalent species associated with invasive candidiasis; however, the distribution of non-albicans Candida spp

Interesting discussion to follow

Yes for sure and some foods act as medicine itself and the are wonderful results when we see the medicinal benefits of some of the foods.

Pfizer-BioNTech COVID-19 vaccine is highly effective against the B.1.1.7 and B.1.351 variants of SARS-CoV-2.

Dear P. K. Farayibi,

Yes, it is correct ICT information technologies turned out to be very helpful in the development of both specific techniques and medical instruments, e.g. in improving surgery, creating implants (3D printing) and also in improving organizational issues, digitization of databases containing patient data and remote systems patient registration via the Internet. Especially the latter issue proved to be very helpful during the SARS-CoV-2 (Covid-19) coronavirus pandemic.

Thank you, Best regards,

Dariusz Prokopowicz

Dear Torsten, here are more recent papers:

Sorry i don't have

I am sorry

Best regards

I have only researched the subject for the Portuguese colonies (Mozambique, East Timor, and Macao) but I have consulted several studies regarding the British and the French colonial empires. One of the books that I found interesting is:

SETH, Suman. Difference and Disease: Medicine, Race, and the Eighteenth-Century British Empire. New York: Cornell University, 2018 (you will find a generous bibliography and sources in this book).

For a complete answer to this interesting question (without any desire for prominence or any petulance) you can read some of my contributions here in "RG", specifically the article "Desire and love: the unfinished man" in which the two "Triangular Models" on Love and ways to evaluate and measure them:

-That of John Lee, from the University of Toronto, which offers us a wide typology of the ways of loving, thus –based on a questionnaire to measure falling in love– has established three primary types of love that are quite independent from each other: - EROS , LUDUS and STORGE, Identifying three “pure” combinations of these primary types: MANIA, PRAGMA and AGAPE.

-And, above all, that of Sternberg in his "Triangular Theory of Love" that considers three primary components: INTIMACY, PASSION and COMMITMENT, one in each vertex of the triangle, thus giving rise to 7 possibilities: INTIMACY: Like, friendship and affection without commitment or passion. ROMANTIC LOVE: Intimacy plus passion, with feelings of proximity and outbursts of passion. PASSION: Love at first sight, fickleness, mental and physical excitement. FATUO OR FALSE LOVE: Passion plus commitment, lightning engagement and wedding before intimacy develops, which usually leads to failure- COMMITMENT: Decision that one loves another person without intimacy or passion, it is an empty love or of convenience. COMPANION LOVE: Commitment plus intimacy, it is a solid but not romantic friendship.

As expected, in real life all these elements are mixed, with COMPLETE or CONSUMED LOVE being the one that combines intimacy, passion and commitment, in the center of the triangle.

I am also looking for the same book too can you please share with me.tesfaneh.shimelis@aau.edu.et

I think the effect will be significant on the progress of treatment, and the world will witness the end of cancer in the future

See attachment...we would benefit a great deal If such cooperatives can be initiated in Africa

Anxiety disorders are one of the most commonly diagnosed mental health problems among students. Anxiety is what we feel when we are worried, tense or afraid – particularly about things that are about to happen, or which we think could happen in the future.

The government does not directly regulate or negotiate the price of drugs. Instead, U.S. drug companies set their prices, but insurers and pharmacies determine how much patients pay out-of-pocket

In the past few years, fractional differential equations have emerged as a reliable blue and well-organized mathematical tool in studying many science and engineering occurrences. Research in fractional differential equations is multidisciplinary and is used in diverse fields such as control systems, elasticity, electric drives, circuits systems, continuum mechanics, heat transfer, quantum mechanics, fluid mechanics, signal analysis, biomathematics, biomedicine, social systems, bioengineering, management, financial systems, traffic flow, turbulence, complex systems, pollution control, and more.

The principal aims of this Research Topic are:

• To bring together mathematicians, scientists, and researchers working in fractional calculus and its real-world applications.

• To encourage the advancement of new computational techniques.

• To study important fractional differential equations arising in real-world problems.

• To expand new trends in the area of fractional differential equations and their real-world applications.

The collected research papers will provide a short but significant explanation of the most critical hot problems in fractional differential equations and their real-world appeal-world.

Dear Pejman Rahmani Nejad thank you for your interesting technical question. In addition to the useful link provided by Lukas Schulig please also have a look at the following relevant article entitled

The paper is freely available as public full text on ResearchGate. According to this article "the most common functional group is the hydroxyl, as its occurrence frequency in all databases is the top one. Moreover, -COOR or -COOH are the second most common functional groups."

This could be a good read on evidential deep learning

check this out.