Medicine - Science topic

Dear Daniel,

A key issue for formulating a research problem is to develop a research language and to define terms precisely. Well, it is first necessary to resolve what we call the evolution of the human species. Whether evolution is a process determined by civilisational factors or not. If, for the purposes of these considerations, we assume that the evolution of living organisms (flora and fauna) is a process that usually takes place over a period of many millions of years, then unfortunately we are not in a position to say what human civilisation and technology will look like in a few million years. Besides, it is unlikely that human civilisation will survive another few centuries let alone a few million years. In my opinion, a particularly important issue is whether the technological progress that is taking place will make it possible to create new eco-innovations and green technologies that would make it possible to carry out a complete pro-environmental transformation of the economy in the next few to several years, to build a world based on a sustainable, green closed-circuit economy, in which the consumption of natural resources would be significantly reduced, the level of environmental pollution and greenhouse gas emissions would fall, etc. If this were to be achieved, humanity would avoid a global climate catastrophe and would survive until the 22nd century. Unfortunately, if this plan fails to materialise, the global climate catastrophe resulting from the accelerating process of global warming could, before the end of the present 21st century, annihilate most of the species of flora and fauna still living on planet Earth. For these life forms, an evolution that has lasted millions of years could come to a definitive end. In view of the above, it may also be interesting to consider the evolution of those few physiologically and organically simpler life forms that would manage to survive a global climate catastrophe, with the additional assumption that, unfortunately, humans will not be among these life forms. The evolution of dinosaurs took hundreds of millions of years and did not result in the emergence of intelligent dinosaurs with comparable intelligence to humans. Of course, we do not know what would have happened if a large asteroid had not hit the Earth and annihilated the dinosaurs. Human evolution, on the other hand, is only about 1 million years. During this period, an intelligent life form arose, built a civilisation and dominated the entire planet 'ecosystem'. But is it really intelligent if it leads to its own annihilation and, in the process, the annihilation of many other life forms. Is this a dead end of the evolutionary process. No, because evolution is not a deliberate process, but a mechanism for the continued existence of specific forms of life adapting to the slowly changing conditions of the ecosystemic, natural, climatic, geological, cosmic environment, and so on. Does evolution interpreted in this way apply to modern humans homo sapiens. In my opinion NO.

Best regards,

Dariusz

Dear Mozhgan Norouzi, thank you very much for your reply!

A patient with desminopathy survived Covid-19 six months ago without pneumonia, but with a temporary loss of smell and taste. After Covid-19, we note an accelerated progression of desminopathy, penetration accelerates, new muscles are quickly involved in the pathological process, muscle mass decreases, and heart function worsens. Perhaps the infection or its consequences are somehow connected with the mechanism of progression of desminopathy?

Once Daily (OD) or 24 hourly, both can be written.

This is an excellent detailed and practical article which demonstrates the importance of Artificial Intelligence in the crucial field of diagnostics:

https://sitn.hms.harvard.edu/flash/2019/artificial-intelligence-in-medicine-applications-implications-and-limitations/

Best regards and good wishes!

Anxiety disorder can be acute or chronic or due to other chronic disorders. Depending on the severity of the disorder , the biomarkers levels will change. The blood cortisol levels also be marker and can used monitor in the health individuals.

Have a look at this useful RG link for insights.

Jiří Kroc: Greetings Prof. Kroc. In neurology the cutting-edge research is on 1) neurodegeneration, 2) neuroprotection, 3) the unification/entanglement between the nervous system and the immune system and 4) disorders of consciousness. thanks, Mustafa.

Dear Vladimir M Moskovkin . See the following useful link: https://www.jica.go.jp/jica-ri/IFIC_and_JBICI-Studies/english/publications/reports/study/topical/approaches/pdf/higher_02.pdf

Ahmed Bakr, I can’t really comment, but it sounds reasonable! You could also classify them as “weaker” and “stronger”, implying that these are relative rather than absolute. Sometimes we get caught up in the statistics… try picking out one of the weak ones and try to understand what is going on in the real world, not from a statistical perspective - what is correlated with what, and what sorts of influences (in real life) might be weakening the relationship?

Best !!

AN

interested

Re: anxiety as a side effect of bicalutamide

THIS IS FROM WIKIPEDIA [paraphrased and abbreviated]: Side effects due to androgen deprivation include mild-to-moderate breast tenderness and enlargement in up to 80% of men, along with feminisation. Reduced body hair and muscle mass, feminine fat distribution, reduced penile length, and decreased semen volume can occur, along with hot flashes, sexual dysfunction, depression, fatigue, weakness and anemia. Bicalutamide monotherapy has also been associated with an increase in the rate of heart failure.

MY OPINION: in view of this side effect profile, depression, anxiety and id-percieved stress, in a percentage of subjects, is to be expected.

Stress-related intracellular hypothyroidism (IC), producing CFS-like symptoms including anxiety, confusion and cognitive loss, will result.

Incidentally, cardiomyopathy resulting from IC is the probable cause of the heart failure mentioned in the Wikipedia article.

Thank you, Laura! I'll have a look to see if it makes sense for me to participate. I am not a health care practitioner, though. I guess I responded to your call mainly in the role of a (concerned) citizen and patient (being on the receiving end of our German health care system). I am mostly concerned with ethical issues. These include, in my view, that, for instance, certain aspects of the doctor-patient interaction should not be digitized - neither in the sense of being digitally stored, nor even documented at all. I know this is a sensitive issue and probably speaks against the trend of increasing documentation, admin etc. in the health care system. Moreover, I think that we should exercise utmost care in not to overdo replacing physical (vis-a-vis/in-person/face-to-face) interaction between doctor and patient by digital communication. I see very grave dangers there. Anyway, at the end of the day, I think our great tradition of medical practise evolved out of the ancient, humanistic Graeco-Roman tradition (Hippocrates etc.). I think we must never loose this "human touch" in medicine. This is my main concern with the risk of over-digitising the health care system.

Thank you & all the best!

Julius

I advise you to just be patient and be at rest since the decision is still in progress on your manuscript, it might end up in your favor

Dear colleagues, how is it possible to protect neurons, oligodendrocytes, any cell against injurious agencies that are poorly known, or if relevant evidence is not paid attention to, as shown at www.ms-info.net and in similar publications?

I think that the best way is keep the house especially the room of the patients clean and healthy. Not dusty, full of ash, smoke residu, spider web, bad humidity, and other poluttants. Sun light and fresh air are also very important.

Housework is important to help this kind of case.

Healthy plant-based foods may lower risk and severity of COVID-19.

Thank you

Till upto OmicronBA.1-BA1.1- B.A.2 variant -https://nature.us17.list-manage.com/track/click?u=2c6057c528fdc6f73fa196d9d&id=1400a357d2&e=5944515236.

Besides the ethics, this case report can be controlled and criticized by others officially, in order to be approved.

Nalidixic acid - A NSAID grs of drugs or pain killer .REF : en.wikipedia.org ( Image Source ) .

I personally believe that imaging examinations in covid should be rapid, simple and executable at the patient's bedside and therefore I believe that the most useful is LUS.

Unfortunately still today is used the chest X-ray that has been proven useless.

The purpose of LUS is to stage the pathology in order to predict its evolution, unfavorable or favorable. With LUS and blood gas analysis we can determine which patients should be discharged at home in a period when bed meals are scarce in all hospitals.

Dear Hamidreza Khalounejad , there are various types of modalities that can be beneficial for persons with MS.

I have explained all types with detailed information such as volume, repetitions, exercise selection, etc particularly during COVID-19 in my latest article, which you can find it here:

Dear Dr Sunny Chi Lik Au . See the following useful RG link:

Dear Eleas,

If I understand correctly your question is with respect to the chemical reactivity of an NCE for its target.

Most commonly high chemical reactivity is not seen as an advantage. First the molecule needs sufficient stability for shelf life, limit impurities... Then reactivity may lead to safety issues if this leads to reaction with proteins other than your intended target. A variation on this theme is also formation of reactive metabolites that can cause liver toxicity; this is linked to the original molecule having reactive features or groups that are made reactive when oxidized (oxygenated).

However, reactivity towards the intended target can be very effective for inhibition from covalent binding. This can for example allow to decuple PK and PD (prolonged PD depending on target turn-over). For this to be effective it needs to be specific: reactive "warhead" reacts only with the intended target when molecule specifically bound and not with relevant off-targets. An example of this you can read about is remibrutinib.

EVIDENCE

And Epigenetics

Evidence:

@ Anwar, TiO2 nanoparticles is an effective microbicide agents, which have the advantage of improved safety and stability compared to organic antimicrobial agents. Titanium dioxide is also used in most sunscreens to block UVA and UVB rays. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups.

Check https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555946/

Resistant exercises can tire MS disease quickly. This is an undesirable situation in patients with MS.

I recommend more ROM exercises and short-term isometric exercises.

Also check..

This depend on the drug bioavailability , way of excretion may be differ than that in animals all these should be taken in consideration

Publishing on a particular area does not require one to necessarily have a certificate in that area. However, if you find yourself to be inadequately equipped with the requisite knowledge to do a good job in that specific field, you may overcome that by collaborating with someone with that knowledge so that together you can bring out a very good and scientific work.

Former USSR traditional lecturers with great academicians, undoubtedly those times won't be repeated anywhere, Prof. Henrik G.S. Arvidsson

The best MS exercises are aerobic exercises, stretching, and progressive strength training. Aerobic exercise is any activity that increases your heart rate, like walking, jogging, or swimming. You just don't want to overdo it—it should be done at a moderate level. https://www.pennmedicine.org/updates/blogs/neuroscience-blog/2017/may/multiple-sclerosis-and-exercise

The change in the level of uric acid and biochemical parameters in a patient with an identified case of desminopathy is presented in the article https://www.researchgate.net/publication/357311034_CHANGE_IN_REDOX_STATUS_AND_BIOCHEMICAL_PARAMETERS_IN_PATIENT_WITH_DESMINOPATHY_T341P_SEVERAL_YEARS_AFTER_DISEASE_SYMPTOMS_ONSET

Have a look at this useful RG link.

Hello. This topic is not exactly my field, so I cannot give you a satisfactory answer. I will be happy to follow all the news and discussions in this field.

Regards, Zlata Felc.

Please see these links for info on health and consequences of COVID-19 for people with disabilities:

Hi Liliana,

Yes, you are right. There is a plenty of discussion in this area. Please find below some guidelines.

There are four legal elements which must be proven: a professional duty owed to the patient; breach of such duty; injury caused by the breach; and (4) resulting damages.

In general, malpractice claims are adjudicated in state courts according to laws (e.g., USA), which typically require three elements for a successful claim: the patient suffered an adverse event; the provider caused the event due to action or inaction; and 3) the provider was negligent, which essentially entails showing that the provider took less care than that which is customarily practiced by the average member of the profession in good standing, given the circumstances of the doctor and the patient. Collectively, this three-part test of the validity of a malpractice claim is known as the “negligence rule.” In theory, this rule should provide compensation to iatrogenically injured patients and lead doctors to take appropriate precautions against accidental harm. In practice, however, the rule performs poorly on both dimensions.

Dear Rafi Al-Ani Do have a look at the following discussion here on RG: https://www.researchgate.net/post/Beware_of_these_kinds_of_emails

Conclusion: avoid.

Best regards.

please eloborate what you mean by bloodlessness ? If you are talking about anemia, then a balanced diet and vitamin supplements are needed.

(only one point). maybe there is a difference to state how the image was made and how the scale could be, even though the scale bar is almost approximately at the same level each time. STM, (scanneling Tuning Microscope, false colour, the blacvk and white images, maybe the microscope taken with this 10x, objectives, and so on.All these give ideas on how the scale bars are.... even though I think it is ignored data.

Have a look at this useful link.

You can publish your study protocols in any of the journals which has scope of your title. Example: BMC, BMJ Open, Clinical Trials,… etc.

Please have look on our(Eminent Biosciences (EMBS)) collaborations.. and let me know if interested to associate with us

Here is our lab page: https://www.eminentbio.com/home/members

Here is our publication: https://www.eminentbio.com/home/Publication

Our recent publications In collaborations with industries and academia in India and world wide.

Our Lab EMBS's Publication In collaboration with Universidad Tecnológica Metropolitana, Santiago, Chile. Publication Link: https://pubmed.ncbi.nlm.nih.gov/33397265/

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Our Lab EMBS's Publication In collaboration with Icahn Institute of Genomics and Multiscale Biology,, Mount Sinai Health System, Manhattan, NY, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918

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Principal Scientist & Director,

Eminent Biosciences.

Mob :+91 97522 95342

Dear Pr Brücher,

Thank you for sharing with us these useful informations.

Best regards,

Pr Hambaba

Please go through the following RG links.

The SARS-CoV-2 (Covid-19) coronavirus pandemic is a global epidemic. On a global scale, the state of the pandemic in March 2020 was announced by the World Health Organization. Therefore, this organization could declare the end of the pandemic. On the other hand, the end of the epidemic on a regional, national or local scale can be announced by national central institutions of the health care system, including the ministries of health, in agreement with the government. In order to be able to declare the end of the epidemic on a national, regional or local scale, it is necessary to have a relatively large decrease in the number of new coronavirus infections, a decrease in the number of people seriously ill with Covid-19 disease and deaths caused by this disease. The decrease in Coronavirus infections and in sick people should be sustained in a longer period, i.e. min. several months, taking into account the periods of possible occurrence of subsequent epidemic waves caused by new variants of the Coronavirus and occurring in other regions of the world. In addition, an important factor that may be taken into account in the event of declaring the end of a pandemic on a global scale or an epidemic on a regional scale will be the level of vaccination of citizens with highly effective vaccines against Coronavirus and the level of social, collective immunity of the society achieved thanks to these vaccines.

Best regards,

Dariusz Prokopowicz

Hi Dr Swayamprakash Patel . I hope the following link could help:

I think depends on

1. Quality of Journal which depends on citations, Quartile, Indexing, Impact Factor etc.

2. Novelty

Regards

Thanks you, dear Dr.Mark Louis Weiss

dentistry needs only few drugs to be remembered, procedures like extractions and root canal need common antibiotics, to follow empirical use pls know few gram positive acting drugs and some mixed infection drugs, we use anti amoebic drugs as well. anti- inflammatory and analgesics are routinely used, need to remember few of it. Beware of drug interactions especially metronidazole should not be taken along with alcohol

some emergency drugs like hematinics, to stop bleeding and anti allergic drugs should be learned

for oral lesions need to know about anti oxidants, and few local steroids ointments, some gum paints and aesthetic gels for pain relief

as a beginner if you know these you get confidence

Check https://www.lesker.com/materials-division.cfm?section=evaporation-materials

CDC considers a person to have a fever when he or she has a measured temperature of 100.4° F (38° C) or greater, or feels warm to the touch, or gives a history of feeling feverish.

https://www.cdc.gov/quarantine/air/reporting-deaths-illness/definitions-symptoms-reportable-illnesses.html#:~:text=CDC%20considers%20a%20person%20to,history%20of%20feeling%20feverish.

With Regenerative Medicine, using stem cells, the ongoing Programs are doing it, with good results and promising expectations.

Dear Roy Bagus Kurniawan

I'm assuming the pairs have correlation coefficient >= 0.7 (r=0.07 suggests little correlation).

If you have 3 distinct pairs, I would suggest eliminating one variable from each pair leaving the most significant ones in the set. After that, you can proceed with a stepwise regression, if needed.

Another possible solution would be implementing a dimension reduction technique (i.e. principal component analysis) to reduce the number of predicting factors.

If you require any further information, let me know.

Best wishes,

Francesco

Todavía no se puede predecir q desaparecerá el Covid 19. Al parecer tendremos q convivir con él e inmunizarnos con las vacunas aprobadas por la OMS.

Please also have a look at this useful link.

Some references-

DOI: 10.1016/S2222-1808(12)60173-X

Ringworm is a Hard Cycle to Break - DTN/Progressive Farmer

Theoretically yes, but in the long run the human species would end up adapting its immune defense mechanisms and would survive ... yes, the cost in human lives would be incalculable in the short and medium term

I think it is not mendatory and I agree with @Shin Murakami

Studies providing the evidence of MSG toxic effects have raised the increasing interest in MSG intake as flavor enhancer. Neurotoxic effects in brain, obesity and metabolic defects, „Chinese restaurant syndrome“ and detrimental effects on sex organs are the most discussed in the connection with MSG intake. http://ibimapublishing.com/articles/JMED/2013/608765/

I Follow.

https://www.mdpi.com › pdfPDF

Sentimental Analysis of COVID-19 Tweets Using Deep ... - MDPI

I don't think there would be a generic tutorial for analysing a EHR, they are all different and the software should provide help on how to search a topic. Unfortunately coding classifications systems are different across the world and within countries. See that there is considerbale variation of coding and quality. Not even HL7 is uniformly applied in the UK as a health data standard https://en.wikipedia.org/wiki/Health_Level_7 It's a difficult problem.