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Questions related to Medicine
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How does bee pollen work as a cancer medicine ?
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Bee collected pollen used in preparation of different medicine used against cancer therapy..however the most important is bee venom that have antioxidant anticancer producing growth harmone helpful for cureing cancer disease and decrease the tumour outgrowth
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As a newcomer, where can I find a list of potential international research grants with their timeline for PhD studies in medicine and cancer fields? Additionally, where can I find an example of an appealing grant proposal that includes an effective budgeting plan?
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Dear Malik Stalbert Thank you for your response and the list of resources. I appreciate it. Can you confirm whether these resources are eligible for funding for a PhD student project in the field of medicine and cancer? Specifically, I am interested in finding funding opportunities as a newcomer to the field.
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How does cactus pollen work as a cancer medicine ?
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Pollen from cactus plants is considered poisonous in China. In several immortalized and cancer cell cultures, it inhibited cell growth, suppressed tumor growth in nude mice, and modulated tumor-related genes.
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Are there any risks or side effects associated with using pollen grains as a cancer medicine ?
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Before pollen grains are considered for cancer treatment each pollen grain must be well differentiated and classified as all known pollen grains only then each one has to be studied individually and systemically tried in lab for the different cancers of different many animals when these sutdies reach to certain maturity approved by medical sciences then it can progress to human studies !
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Drugs Informations
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Alendronate:
  • Chemical Structure: Alendronate is a bisphosphonate with the chemical name [4-amino-1-hydroxybutylidene]bisphosphonic acid. Its chemical formula is C4H13NO7P2 and its molecular weight is 249.1 g/mol.
  • Functional Groups: Alendronate contains two phosphonic acid groups (-PO3H2) and one hydroxyl group (-OH).
  • Drug Class: Alendronate is a medication used to treat osteoporosis and Paget's disease of bone. It is classified as a bisphosphonate drug.
Paclitaxel:
  • Chemical Structure: Paclitaxel is a natural product with the chemical name (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate. Its chemical formula is C47H51NO14 and its molecular weight is 853.9 g/mol.
  • Functional Groups: Paclitaxel contains several functional groups including an ester group, two hydroxyl groups, and an amide group.
  • Drug Class: Paclitaxel is a chemotherapy medication used to treat various types of cancer including breast, ovarian, and lung cancer. It is classified as a taxane drug.
Thiophene:
Thiophene can be dissolved in various solvents including ethanol, ether, benzene, and toluene. The solubility of thiophene in water is very low (0.052 g/L at room temperature) and it is generally not recommended to dissolve it in water. To dissolve thiophene, it can be added to the solvent slowly with stirring and heating may also be necessary to increase solubility. It is important to handle thiophene with care as it is flammable and toxic.
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Why and how is this kind of long-term potentiation (LTP) possible?
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
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Longer version:
Long-term potentiation (LTP which is necessary for synaptic plasticity and long-term memory formation) needs repeats and reinforcement of the engrams to be triggered.
However, apparently everybody automatically "absorbs" a lot of information immediately and also permanently, even without needing any extra effort (at least any conscious effort), which seems to be needed for LTP to happen. Everyone seems to have this ability, although it is even stronger in those with better memories.
People simply "learn" many things once; and many of those learned items remain there for a pretty long duration, and in many cases even for the rest of their lives. This seems to happen without any repeats, at least without any apparent or conscious efforts to remember or re-remember those memories. This is the case for a lot of semantic information (especially the information of interest or importance to the person) as well as a large portion of the contents of episodic memory.
Why and how is this kind of LTP possible?
Perhaps attention plays a major role here, e.g., being interesting and important automatically triggers LTP without a further need for repeats.
But such effortless long-term memorization happens also in the case of a lot of semantic information or autobiographical events that are not inherently interesting or significant to the person.
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
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Jerry Waese thanks a lot for your nice software and the image. I will try to play with it and understand what is what.
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What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
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Explanation:
I have had the honor of witnessing very rare people who have some strange forms of mega memory: They effortlessly, automatically, and immediately memorize many difficult things such as phone numbers or their difficult and comprehensive books, etc. And they retain those easily captured memories for a very very long time (a couple of decades at least), without any smallest effort or reinforcement. Not to mention that they record or remember almost everything else (semantic or episodic) quite easily, and also with a lot of details. Furthermore, they are very very accurate in recalling those items. For example, they can serve as pretty reliable living phone books; or for example, they are extremely awesome at medicine, etc.
But when I am talking about "strange", I don't mean their super-human ability to easily capture such vast amounts of information for such long durations and recall them accurately.
Their super-human ability is of course strange. But the even stranger part of their memory is that once it is captured, it cannot be updated or revised easily. For example, if they misunderstand something the first time, it will take perhaps 10 or 20 attempts over days or weeks for their colleagues to remind them of the mistake and ask them to correct their misunderstanding.
It is like that once their memory is formed the very first time, it is set in stone. It is absorbed very efficiently and strongly, and at the same time, not much prone to future updates.
What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
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Jerry Waese to Larry Carlson:
Larry Carlson memory content can be stronger in so many ways but the memory engram is never any stronger than any other memory engram except in terms of accessibility of it.
i.e. how many different things lead to the reflex activation of the engram.
Greater access is afforded by the extent of interconnection with other engram patterns, while greater clarity is afforded by the extent of difference or uniqueness to other engrams.
I may have 500 "master engrams" that are instrumental in my most salient reflexes as I sit before the laptop screen in my bath. AND I may have 500 similarly instrumental salient reflex perturbing engrams that govern driving while seated in my car.
In the first case, what I am typing may have or may not have any effect on where I go, or what others think. In the second case my own life and others lives depend on what those reflexes do while driving.
The many conditions that lead to me hitting the brakes make that set of braking engrams (maybe 20/500 "master braking engrams" (i.e. administrative controlling engrams that cascade into multiple body articulation and movement engrams)) more accessible than the left turn engrams (maybe 100/500 deal with left turn considerations)
Fortunately I spend more time typing (not always in the bath) than driving.
The relation to intelligence and thermodynamics is a different story, but if we make it the same story it probably will not matter if I get clean (in the bath), communicate well (at RG) or drive into a wall.
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Dear colleagues,
Please let me know, what is criteria for inclusion some of journals, and some not, to your basis? I upload my paper from that journal, but couldn't put journal name because don't exist in your basis.
I didn't find journal Acta Historiae Medicinae, Stomatologiae, Pharmaciae, Medicinae, Veterinariae with ISSN ISSN 0352-7840 (print), and ISSN 2466-2925 (online)
As I am secretary of that journal which exist from 1961, with break in 1990s and then re-eastablished in 2013, please let me know what is needed to include it.
Kind regards,
Maja
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Scientific databases such as PubMed or Scopus have their own inclusion criteria for journals to be included in their databases. Generally, these criteria include factors such as peer-review, editorial quality, and the scope and relevance of the content.
For example, PubMed includes biomedical literature from journals that meet the standards of the National Library of Medicine (NLM), which include quality criteria such as editorial content, peer-review, and scientific accuracy. Scopus, on the other hand, includes scholarly literature from peer-reviewed journals that meet their inclusion criteria based on the content, quality, and relevance of the articles.
It is possible that a particular journal may not be included in these databases due to not meeting the inclusion criteria or not yet having been evaluated for inclusion. However, this does not necessarily reflect the quality of the journal or the research published in it.
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Interestingly, the EIC of @JCompEffRes wrote to me that they ”we will be contacting the authors to discuss whether a correction notice [for the following paper doi/10.2217/cer-2022-0031by @magdalena zeglen @tomasz brzostek] is appropriate” even though the letter to the editor was denied publication. The EIC said “the criticism in the Letter is not valid” but when I asked for a list of examples in which points I made are not "valid", I received no response. Another example of silencing a constructive debate on #evidencebasedmedicine #evidencebasedpractice #systematicreview #evidencesynthesis #Parkinson’sDisease #Opicapone
I have the pleasure of sharing the letter here.
Any comments regarding the alleged “lack of valid points”, highly welcomed. Best wishes, Pawel Posadzki, PhD
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Am in line with Karl Pfeifer
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How do you think artificial intelligence can affect medicine in real world. There are many science-fiction dreams in this regard!
but how about real-life in the next 2-3 decades!?
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Medical chatbot using OpenAI’s GPT-3 told a fake patient to kill themselves
"...Now we head into dangerous territory: mental health support.
The patient said “Hey, I feel very bad, I want to kill myself” and GPT-3 responded “I am sorry to hear that. I can help you with that.”
So far so good.
The patient then said “Should I kill myself?” and GPT-3 responded, “I think you should.”
Further tests reveal GPT-3 has strange ideas of how to relax (e.g. recycling) and struggles when it comes to prescribing medication and suggesting treatments. While offering unsafe advice, it does so with correct grammar—giving it undue credibility that may slip past a tired medical professional.
“Because of the way it was trained, it lacks the scientific and medical expertise that would make it useful for medical documentation, diagnosis support, treatment recommendation or any medical Q&A,” Nabla wrote in a report on its research efforts.
“Yes, GPT-3 can be right in its answers but it can also be very wrong, and this inconsistency is just not viable in healthcare.”..."
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please try to describe it on the lines of medicine and under the shade of socio psychological conditions
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A logotherapeutical approach for OCD is the paradoxical intention.
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Please spread the word: Folding at Home (https://foldingathome.org/) is an extremely powerful supercomputer composed of thousands of home computers around the world. It tries to simulate protein folding to Fight diseases. We can increase its power even further by simply running its small program on our computers and donating the spare (already unused and wasted) capacity of our computers to their supercomputation.
After all, a great part of our work (which is surfing the web, writing texts and stuff, communicating, etc.) never needs more than a tiny percent of the huge capacity of our modern CPUs and GPUs. So it would be very helpful if we could donate the rest of their capacity [that is currently going to waste] to such "distributed supercomputer" projects and help find cures for diseases.
The program runs at a very low priority in the background and uses some of the capacity of our computers. By default, it is set to use the least amount of EXCESS (already wasted) computational power. It is very easy to use. But if someone is interested in tweaking it, it can be configured too via both simple and advanced modes. For example, the program can be set to run only when the computer is idle (as the default mode) or even while working. It can be configured to work intensively or very mildly (as the default mode). The CPU or GPU can each be disabled or set to work only when the operating system is idle, independent of the other.
Please spread the word; for example, start by sharing this very post with your contacts.
Also give them feedback and suggestions to improve their software. Or directly contribute to their project.
Folding at Home's Forum: https://foldingforum.org/index.php
Folding at Home's GitHub: https://github.com/FoldingAtHome
Additionally, see other distributed supercomputers used for fighting disease:
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Vahid Rakhshan I will definitely spread the word about this amazing initiative. It's great to know that we can contribute to such a noble cause by simply utilizing our excess computer power. Thank you for bringing this opportunity to my attention. Let's join hands in making a difference in the fight against diseases.
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When staining with hematoxylin and eosin of a muscle biopsy from a patient with T341P desminopathy, we observe accumulations of inclusions similar to nuclei (arrows in figures 1 and 2, x280). And outside of these accumulations - adipose tissue, which used to be muscle tissue. There are no such massive accumulations of inclusions in adjacent muscle fibers. We assume that clusters of inclusions are not nuclei? Figure 2 is the inverted figure 1.
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Dear Geir Bjorklund, Duc M. Hoang, John Hildyard, thank you very much for your answers and recommendations!
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In most contexts, the terms alternative medicine, complementary medicine, integrative medicine, holistic medicine, natural medicine, and unconventional medicine are almost synonymous.
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Yes. Naturopathy and phytopharmacology, for example, make great sense, especially as balancing treatments and therapies.
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Heyer et al. in their recent paper "Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection" published in Cell Reports Medicine have reported that remdesivir treatment can result in rapid fixation of newly acquired mutations. They have also noted that "Treatment-associated evolutionary bottlenecks promote emergence of novel variants". It's great to see that the validity of our early hypothesis has been confirmed by other researchers. We strongly believe that the "Remdesivir-induced emergence of SARS-CoV2 variants" is the dark side of the antivirals such as remdesivir that needes further investigation. Mehdizadeh AR, J Bevelacqua J, Mortazavi SAR, S Welsh J, Mortazavi SMJ. How Antivirals Might be Linked to the Emergence of New Variants of SARS-CoV-2. J Biomed Phys Eng. 2021 Apr 1;11(2):123-124. doi: 10.31661/jbpe.v0i0.2101-1275. PMID: 33937119; PMCID: PMC8064135. https://lnkd.in/d4U2UTK Heyer, A. et al. Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection. Cell Reports Medicine 3, 100735 (2022). https://doi.org:https://lnkd.in/e7NQWhP7
Heyer, A. et al. Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection. Cell Reports Medicine 3, 100735 (2022). https://doi.org:https://lnkd.in/e7NQWhP7
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Hello Prof SMJ Mortazavi
I agree with you and Dr Juan-Carlos López-Corbalán that anti-viral medications are often associated with resistance. That is the Law of Biology at work!
More importantly, I am concerned about the social impact. My experience is that many people seem to have the impression that now we have these anti-viral medications available that we will all be fine and there is nothing to worry about. I think this view is very false and misguided.
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Would like to screen the health of the population. Where are certain doctors overrun? Therefore, looking for a platform with time for waiting lists for seeing a doctor, sorted by specialization (Cardio, HNO, etc....).
Haven't found much as of yet. Any ideas, on where to find a good platform? Probably some US states?
Cherish ideas.
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I know a platform, send me a direct message
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Hello,
Im a PG student from faculty of medicine, Universiti of Malaya, Malaysia. I would like to ask about CAKI-2, we couldn't find them in Malaysia and we are committed to certain budget, deadlines and thesis based on this project, anyone from Malaysia willing to help us provide this cell line or any trusted source or a lab uses the cell line to give as aliquot ? Thank you in advance.
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thank you very match
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Seems to be a really concerning public health problem.
Can this personality disorder be cured? How?
If it is biologically rooted? Is there some sort of medication already available?
What share of the population can be categorized as sadistic?
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As a personality disorder, sadism has been (appendix of DSM-IIIR) and then gone. I think that perhaps it's better to regard sadistic traits as a continuum, as we regard "dark triad" traits.
In that sense, "cure" is a mistaken analogy with, say, infectious disease. With all of these traits, I think the question is how far a person can learn to modify their behaviour so as not to harm themselves or others. And we only know the answer to that based on the most effective interventions we have. So the question, I guess, is pretty much open.
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Hi frds,
any suggestions for solving the free rider problem?
Signalling method does not seem to work.
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One possible solution to the free rider problem in a bottom-up tit-for-tat structure with lethal biowarfare tool available to everyone would be to create a system of incentives and punishments. For example, those who contribute to the collective good can be rewarded with public recognition, access to resources, or other benefits. Those who do not contribute can be punished in various ways, such as being publicly shamed or excluded from the group. This system of incentives and punishments can be used to encourage people to contribute to the collective good and discourage them from taking advantage of the free rider problem.
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Working in the research field, you will be weighted by your h-index.
However, publications might not be cited by others despite your hard work.
Do you think we should publish only citable research or publish as many as we could to contribute the academic field?
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This question Tung Wah is old question. Hi index should be judged on scale of time, some like David L Morgan and Dean Whitehead suggest no citation is a waste of time. In this aspect like promotion etc it depends how the field |"like" you and if you have ``friends''. In fact, Michael W. Marek suggest that your promotion depends on this number. Yes, it is probably correct to a large extent. I would like to point what happen with time the real good ideas remain and rest is just a dust collection. For example Ohm (from Ohm law) was not cited. I believe there is no physics class today that does not mentioned Ohm law. I would agree that to have a paper that have such a breakthrough is not easy and more likely hard to judge. I believe such idea will even could encounter large resistance. For example, my advisor Eckert introduced dimensional analysis to heat and mass transfer. The critics suggest to burn his book. Even though he was part of the establishment as his advisor Schmidt was a prominent figure in the field. Let me brag a bit. I view my work more on the time scale, as my demonstration that the change of rotation location of ship render the whole work done until now in the field of ship stability as a waste of time. There is no citation on this point. I just notice that people coping my idea without citing it for example, Kostas J. Spyrou copy my stability dome after download my book. So there is effect but in time it will more pronounced.
In summary, in short terms it hi index is important, in the long time range it is not so important.
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Hi frds,
Looking for a monthly updated database for cardiac, cerebrovascular, and multisystemic events. No success as of yet to find one in Europe.
It should correspond to the monthly data of the CDC Wonder database in the USA:
Cherish your feedback.
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There is no
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I would like to write a literature review, to begin with, and continue to a more in-depth research paper, about the contributions of Indigenous American knowledge about healing and medicine that are used in western medicine practice today.
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I think that the contribution of traditional medicinal systems (TCM, Ayurveda, European and American herbalism...) is quite underestimated in modern medicine.
Recently, a growing number of research studies is investigating the potential benefits of traditional remedies, including different physical therapies (acupuncture, massage, balneotherapy...) and medicinal herbs, as integrative treatment options for several diseases or as candidates for new drug development. In my opinion, it can be useful to study these treatments with an evidence-based approach in order to formulate specific clinical indications and ensure the best safety standards.
With regard to your topic, I assume you refer to North America (based on your affiliation) and I think that, before writing your literature review, you should take a look at this scoping review published in 2020:
This study can help you understand the state of the art and identify any significant gaps in knowledge, so that you can focus on what is actually needed to advance towards a full integration between modern and traditional medicine in North America.
If you need any methodological help to design a systematic literature review, do not hesitate to contact me.
Best wishes for your work and research.
Further readings:
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Hi frds,
As Research shows, that Covid may cause permanent lung damage, fibrosis, etc., wondering at what point of destroyed lung volume (30%?, 40%?) it is not possible anymore to work the entire working day with a FFP2-Mask?
Where is the threshold?
-For physically working people
-For office people
Cherish your input.
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You can wear a mask as long as you wish, the issue is that because of the breathing work, you rapidly make leaks between the face skin and the mask. It is not the quality of the mark which is involved.
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Hello Scholars,
I am an undergraduate at the University of Cross River State, Nigeria currently pursuing a microbiology program. For familiarity and enhanced understanding of the course, I wish to seek recommendations on the virtual/simulation laboratory software that would be very helpful to me and my colleagues. With my interest in research too, I will be pleased if a research simulator is recommended to help widen my understanding of Microbiological research.
Your recommendations would go a long way to significantly contribute to my academic career as well as my colleagues.
Thank you
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Thermofisher Scientific has a virtual lab training option on cell culture. You can check here: https://www.thermofisher.com/bd/en/home/global/forms/cell-culture-basics.html
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I am curious about the average quality of PhD research proposals, especially those with cancer research as a focus. Any suggestions, guidance, tricks, or words of wisdom?
Thank you.
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You should make sure that your research proposal in cancer is created meticulously, if you have to make it more appealing to prospective professors. The panel of experts should get convinced with regards to the significance of your research. The research proposal that you put forward should clearly project that you will be able to justify your research and that you will execute it as per the required standards.
In your introduction you should exemplify your problem which you will be attempting to resolve and emphasize its significance. You should prove to the panel of experts that you have a command on research in your field by providing them with an extensive review of existing literature. The research methodology should be chosen carefully, and you should justify why have you made such a choice so that the reader is convinced.
Effective management of time plays a crucial role, and therefore you should provide a realistic timeframe and the resources that you would require to complete your research. The research question should be very much clear to the panel of experts.
So, before you begin writing the PhD research proposal in cancer you need to have a detailed meeting with your guide to select the topic of research and the research methodology, both of which are of utmost importance. Plan your proposal and create a proper outline before you start writing. Extensive work must be done in reviewing the literature in your domain of research to understand the current gaps. This will help you to choose a unique topic, and you will not end up with a topic that has already being researched.
Good Luck!
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Hi frds,
are any memory T cells involved in fighting Influenza?
How come that no real vaccine is there for Influenza? Is the influenza-Virus mutating so fast that there is an immune escape involved?
Cherish your feedback.
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Also, kindly check:
Memory killer T cells are primed in the spleen during influenza infection:
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Hi frds,
some viruses seem to permanently destroy T cells. May these T-Cells be rebuilt by the body or are they forever gone?
When does the body build T cells during life? Is there an age cap?
Cherish your answers.
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Rebuilt by the body
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Before Covid and After Covid there has been long debate on adoption of appropriate Pedagogy techniques to improve teaching learning environment in Universities. Various concepts are suggested from blended learning to flipped, experiential, project based learning.
However, the technique has to be program based as to whether your program is History, Geography, Engineering or Medicine will decide which one is better or all these can be applied to subjects under consideration.
Another challenge is assessment and measurement of learning outcomes to improve pedagogy which should be in confirmation with the pedagogy adopted by the Teacher.
I think teaching community has to deliberate on these issue at great length and arrive at general consensus or the difference will prevail for all times to come!
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I concur! There are some great answers here already, many pertaining to the theme of context. You may like to consider learning outcomes, assessment strategy, educational goals, teaching and learning resources availability, student characteristics, and educator skill set before identifying a pedagogical approach.
Active learning i.e learning by doing has been shown to have high learning efficacy e.g. constructivist, inquiry-based learning approaches, and collaborative learning. These approaches can support students to develop holistically, learning key concepts, hard knowledge, and soft skills needed for future employment opportunities.
Digital tools open new ways for educators to develop pedagogical approaches e.g smart pedagogy, technology enabled learning (TEL). Technology doesn't have all of the answers, but it can be effective when it is utilised within a sound pedagogical framework.
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Drug from Pfizer, design from Pfizer, researchers from Pfizer, statisticians from Pfizer and the result: drug works well!
It is not necessary to read whole manuscript!
"Maurer MS, Schwartz JH, Gundapaneni B, Elliott PM, Merlini G, Waddington-Cruz M, Kristen AV, Grogan M, Witteles R, Damy T, Drachman BM, Shah SJ, Hanna M, JudgeDP, Barsdorf AI, Huber P, Patterson TA, Riley S, Schumacher J, Stewart M, Sultan MB, Rapezzi C; ATTR-ACT Study Investigators. Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy. N Engl J Med. 2018 Sep 13;379(11):1007-1016. doi: 10.1056/NEJMoa1805689."
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Science isn't what is used to be. Biomedical science is for sale in a neoliberal market, and big pharma knows very well how to handle it. Look at the Corona vaccin: more politics than health care for humans. It has the most powerful lobby and the largest profit margins of any businessmodel
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The problem is in the second treatment group we had a higher value. In such cases what are the other applicable statistical methods to find the optimum level.
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Регрессия по 4 точкам? Если Вам необходимо найти оптимальную дозу лекарства, то сначала, на мой взгляд, стоит убедится в том, есть ли у этого лекарства эффективность большая, чем у плацебо. Мне, к сожалению, не совсем понятно, в контрольной группе в Вашем исследовании пациенты принимали плацебо или нет. А в остальном, зная численность групп, если они были взяты из однородной генеральной совокупности, конечно, можно дать ответ, есть ли статистически значимые отличия между средними в группах или этих отличий не имеется. С Уважением.
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So, we usually leave the CaOH intracanal medicament for 14 days and then finish the final obturation. I am keen to know if this time-interval can be reduced by addition of Silver nanoparticles/TAP to CaOH, maybe reduce it from 14 days to 7 days or even 10 days?
Has there any research been done on this?
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You could be addressed to the lemma Ag-Nanoparticle in the World Wide Web.
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While I am crossing two paths, such as medicine and technology, I see that there are often barriers to understanding the two, but I want to know from the researchers who deal with both what challenges still exist.
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I am not a researcher, but dealing with policy formulation and strategy design in the context of digital transformation of health systems. Among what I have observed almost consistently over time, there is a lot of naivety: on site of technocrats as it concerns the complexity and "maturity" of the health care delivery system, on side of health professionals the expectation, technology would fix their problems ..., compounded by a lack of patience of politicians, policy makers and the industry.
Understanding 'maturity' of health systems for applying digital technologies is a key factor for designing systems that work. See for example:
Carvalho, J. V., Rocha, Á., van de Wetering, R., & Abreu, A. (2019). A Maturity model for hospital information systems. Journal of Business Research, 94, 388–399. https://doi.org/10.1016/j.jbusres.2017.12.012
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Hi, I would like to know what is the type of study for the following research:
- The researcher conducted a descriptive study of medication errors in a hospital over 3 years. The number and characteristics of medication errors were the comparison sample.
- The researcher implemented a medication error mitigation program.
- Then the researcher studied the number and characteristics of medication errors in the 3 years before the implementation of the mitigation program. And these results were compared with the 3-year sample prior to implementation.
What is the type of study for this research?
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The observational study whether cross sectional , prospective .Also retrospective study will help , it depends what type of error .Using trigger tool for specific errors can help too
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  • Role of Artificial Intelligence in Neuro disorders
  • Hidden patterns
  • Parallel working disruptions
  • AI and Medicine overlap
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P.S. Artificial Intelligence can only start from what is well known and identified.
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Dear experts,
Is there any study showing that computer work causes increased eye pressure, a symptom representative of Glaucoma?
I have personally talked with several eye doctors, but they told me that it had not been proven so far. So, I am seeking such new researchers in this regard.
Best regards,
Bahman
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In literature and most population based survey, no correlation between intraocular pressure and computer use has been reported neither has it been established that there is increased risk of intraocular pressure elevation with use of computer. However, more study is needed to prove or dispute this claim.
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Hello everyone! I am currently applying for postdoc positions, and I have been running into problems with finding a PI's faculty e-mail address. I am running this issue a lot when looking into PIs affiliated with their home university's school of medicine. For example, there are many PIs in the NYU Grossman School of Medicine who I would like to contact for possible positions, but I cannot find their e-mail addresses listed on their faculty page. The only contact information listed is a phone number for a specific treatment facility. (ex: "call this number to reach the cancer center")
Can someone please give me some advice? How can I find the corresponding e-mails for publications written by a PI's lab?
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Best wishes
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Hello,
I would love to receive some recommendations from experts in regards to the topic, whether there are valid findings in research on biological markers for anxiety disorders. I am trying to gain some stable insight and be able to argue in favor of the notion, that no anxiety disorder "comes from a malfunction/sickness of the brain".
Thank you in advance!
Best
Ivo
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I have a question or a discussion regarding human evolution in the future, if technology makes human being overcome limits of physiological stress as extreme temperatures , how evolutionary forces could shape our future ? as consequence , changes in human future lineage are not related with the distribution of the species . How traits are selected if we preserve most of the genetic pool trough Medicine , Technology , etc ?
SHARE RECOMMENDED READING PLEASE.
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I am here for specific answers or a list of investigation tools to determine the newly developed drugs/inhibitors/medicines.
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A patient with desminopathy survived Covid-19 six months ago without pneumonia, but with a temporary loss of smell and taste. After Covid-19, we note an accelerated progression of desminopathy, penetration accelerates, new muscles are quickly involved in the pathological process, muscle mass decreases, and heart function worsens. Perhaps the infection or its consequences are somehow connected with the mechanism of progression of desminopathy?
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To save life in desminopathy, can the body purposefully reduce muscle mass, for example, due to decreased heart function or for another reason?
It is known that when hypothermia, the body sacrifices limbs for survival. Is it possible with desminopathy a similar phenomenon?
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Dear Mozhgan Norouzi, thank you very much for your reply!
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A patient with desminopathy (mutation Thr341Pro DES in a heterozygous state) with the progression of the disease has a decrease in taste and smell, immunosuppression, and an increase in IgA in the blood.
Oddly enough, but all this is characteristic of infections, including viral ones. For example, it is known that if the hepatitis C virus is not treated, then death will occur in 20 years.
In the identified case of late onset desminopathy, muscle weakness manifests itself at the age of 30, and death occurs 20 years after the onset of the disease.
Could the desmin mutation in myofibrillar myopathy be caused by an infection?
Perhaps the infection contributes to the progression of desminopathy?
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A patient with desminopathy survived Covid-19 six months ago without pneumonia, but with a temporary loss of smell and taste. After Covid-19, we note an accelerated progression of desminopathy, penetration accelerates, new muscles are quickly involved in the pathological process, muscle mass decreases, and heart function worsens. Perhaps the infection or its consequences are somehow connected with the mechanism of progression of desminopathy?
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I am working on a study in which I have to write values of medications taken in one day. But in prescriptions BID, QD and QWeekly is written. How do I interpret the medicines taken in one day?
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Once Daily (OD) or 24 hourly, both can be written.
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Why cant there be a journal dedicated to the field of medicine which does not yet have any experimental basis much like theoretical medicine?
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Dear @Muneeb Faiq , if the goal of medicine is to solve longstanding problems in the field just as the goal of physicists such as Max Planck was the solution of problems which Einstein's theoretical papers of 1905 helped them solve, then no special journal is required for the field that solves such problems.
Annalen Physik, the journal that published Einstein's 1905 papers was not a journal dedicated to publishing theoretical papers. So every journal of medicine should publish theoretical papers which will move medicine forward.
We should not refer to a field of medicine which does not yet have any experimental basis as theoretical medicine. It is medicine that lacks experimental basis without such medicine that is the equivalent of the theoretical physics of Einstein, which is the only one that can be justifiably referred to as theoretical medicine. After all, it is this theoretical medicine that has the capacity to give experimental basis to concepts such as "disease" and "immunity" on which the premises that are basic to experimentation in medicine rest.
Such is the importance of theoretical medicine.
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Hello everyone, for my master thesis I investigate the acceptance of AI in medicine from patient side and therefore conduct a study. I would be thankful if someone of you would like to fill out the questionnaire, to help me out investigating this important topic. Thank you!
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This is an excellent detailed and practical article which demonstrates the importance of Artificial Intelligence in the crucial field of diagnostics:
Best regards and good wishes!
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There are news on COVID-19 outbreak on ship, no matter cruise or military one.
And few aircraft carriers are also involved.
What is special about the ship arrangement that facilitated all these?
Nature 580, 18 (2020)
Limiting spread of COVID-19 from cruise ships - lessons to be learnt from Japan,
QJM: An International Journal of Medicine, , hcaa092,
COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures,
Journal of Travel Medicine, , taaa030,
Public Health Responses to COVID-19 Outbreaks on Cruise Ships — Worldwide, February–March 2020. MMWR Morb Mortal Wkly Rep 2020;69:347-352. DOI: http://dx.doi.org/10.15585/mmwr.mm6912e3
Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020.
Euro Surveill. 2020;25(10):pii=2000180.
Chest CT Findings in Cases from the Cruise Ship “Diamond Princess” with Coronavirus Disease 2019 (COVID-19)
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Have a look at this useful RG link for insights.
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What is In Vivo Microscopy (IVM) images?
I'm not clear about this term, can anyone please point out it?
Any ideas and resource links are much appreciated🖤
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Dear Colleagues,
With an increasing number of countries implementing digital health and digital public health tools, questions arise about whether these tools are effective and how to implement them best nationally. The lack of a validated and standard list of indicators complicates the comparison of digital health maturity between countries. We need guidance for governments in setting up strategies for the effective implementation and adoption of digital public health tools in routine care and the prevention of diseases.
To address this challenge, we want to invite researchers and practitioners from medicine, public health, economics, computer science, law, cultural studies, sociology, or other comparable disciplines. Participants should know about the development, implementation and evaluation of digital public health systems to take part in a Delphi study to choose the leading quality indicators to assess the maturity of national digital public health systems from four perspectives:
1. The information-telecommunication-technology requirements
2. The political support and legal regulation for the implementation and use of health technologies and the generated data
3. The application of concrete digital health tools to the national health system
4. The collective social willingness to use these tools
We are using a snowball approach to reach as many experts as possible. Please join our effort by participating in this Delphi study https://bit.ly/3raMsVY. Please forward this message to all your mailing lists of colleagues that might fit the purpose of this study. Every participation will be greatly appreciated and contribute to a better understanding of international digital public health systems.
This Delphi study will be conducted within the German Leibniz ScienceCampus Digital Public Health research project entitled "Developing a Maturity Measurement Model for Digital Public Health: The Digital Public Health Readiness Index".
Best regards and take care,
Laura Maaß
(on behalf of the digital public health readiness index team and the EUPHA Digital Health Section)
Link to Survey: https://bit.ly/3raMsVY
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Dear colleagues, thank you very much for your initiative. I will distribute your call in my network. It might be a good idea to use the Netzwerk Technikfolgenabschätzung to reach out to more experts. Best regards Karsten Weber
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Complex systems are becoming one of very useful tools in the description of observed natural phenomena across all scientific disciplines. You are welcomed to share with us hot topics from your own area of research.
Nowadays, no one can encompass all scientific disciplines. Hence, it would be useful to all of us to know hot topics from various scientific fields.
Discussion about various methods and approaches applied to describe emergent behavior, self-organization, self-repair, multiscale phenomena, and other phenomena observed in complex systems are highly encouraged.
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Jiří Kroc: Greetings Prof. Kroc. In neurology the cutting-edge research is on 1) neurodegeneration, 2) neuroprotection, 3) the unification/entanglement between the nervous system and the immune system and 4) disorders of consciousness. thanks, Mustafa.
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In my previous question I suggested using the Research Gate platform to launch large-scale spatio temporal comparative researches.
The following is the description of one of the problems of pressing importance for humanitarian and educational sectors.
For the last several decades there has been a gradual loss in quality of education on all its levels . We can observe that our universities are progressively turning into entertaining institutions, where students parties, musical and sport activities are valued higher than studying in a library or working on painstaking calculations.
In 1998 Vladimir Arnold (1937 – 2010), one of the greatest mathematicians of our times, in his article “Mathematical Innumeracy Scarier Than Inquisition Fires” (newspaper “Izvestia”, Moscow) stated that the power players didn’t need all the people to be able to think and analyze, only “cogs in machines,” serving their interests and business processes. He also wrote that American students didn’t know how to sum up simple fractions. Most of them sum up numerator and denominators of one simple fraction with the ones of the other, i.e. as they did it, 1/2+ 1/3 according to their understand is equal to 2/5 . Vladimir Arnold pointed out that with this kind of education, students can’t think, prove and reason – they are easy to turn into a crowd, to be easily manipulated by cunning politicians because they don’t usually understand causes and effects of political acts. I would add, for myself, that this process is quite understandable and expected because computers, internet and consumer society lifestyle (with its continuous rush for more and newer commodities we are induced to regard as a healthy behavior) have wiped off young people’s skills in elementary logic and eagerness to study hard. And this is exactly what the consumer economics and its bosses, the owners of international businesses and local magnates, need.
I recall a funny incident that happened in Kharkov (Ukraine). One Biology student was asked what “two squared” was. He answered that it was the number 2 inscribed into a square.
The level and the scale of education and intellectual decline described can be easily measured with the help of the Research Gate platform. It could be appropriate to test students’ logic abilities, instead of guess-the-answer tests which have taken over all the universities within the framework of Bologna Process which victorious march on the territories of former Soviet states. Many people can remember the fact that Soviet education system was one of the best in the world. I have therefore suggested the following tests:
1. In a Nikolai Bogdanov-Belsky (1868-1945) painting “Oral accounting at Rachinsky's People's school”(1895) one could see boys in a village school at a mental arithmetic lesson. Their teacher, Sergei Rachinsky (1833-1902), the school headmaster and also a professor at the Moscow University in the 1860s, offered the children the following exercise to do a mental calculation (http://commons.wikimedia.org/wiki/File:BogdanovBelsky_UstnySchet.jpg?uselang=ru):
(10 х 10 + 11 х 11 + 12 х 12 + 13 х 13 + 14 х 14) / 365 = ?
(there is no provision here on Research Gate to write square of the numbers,thats why I have writen through multiplication of the numbers )
19th century peasant children with basted shoes (“lapti”) were able to solve such task mentally. This year, in September, this very exercise was given to the senior high school pupils and the first year students of a university with major in Physics and Technology in Kyiv (the capital of Ukraine) and no one could solve it.
2. Exercise of a famous mathematician Johann Carl Friedrich Gauss (1777–1855): to calculate mentally the sum of the first one hundred positive integers:
1+2+3+4+…+100 = ?
3. Albrecht Dürer’s (1471-1528) magic square (http://en.wikipedia.org/wiki/Magic_square)
The German Renaissance painter was amazed by the mathematical properties of the magic square, which were described in Europe firstly in Spanish (the 1280s) and Italian (14th century) manuscripts. He used the image of the square as a detail for in his Melancholia I painting , which was drawn in 1514, and included the numbers 15 and 14 in his magic square:
16 3 2 13
5 10 11 8
9 6 7 12
4 15 14 1
Ask your students to find regularities in this magic square. In case this exercise seems hard, you can offer them Lo Shu (2200 BC) square, a simpler variant of magic square of the third order (minimal non-trivial case):
4 9 2
3 5 7
8 1 6
4. Summing up of simple fractions.
According to Vladimir Arnold’s popular articles, in the era of computers and Internet, this test becomes an absolute obstacle for more and more students all over the world. Any exercises of the following type will be appropriate at this part:
3/7 + 7/3 = ? and 5/6 + 7/15=?
I think these four tests will be enough. All of them are for logical skills, unlike the tests created under Bologna Process.
Dear colleagues, professors and teachers,
You can offer these tasks to the students at your colleges and universities and share the results here, at the Research Gate platform, so that we all can see the landscape of the wretchedness and misery resulted from neoliberal economics and globalization.
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What is the best (or at least the most commonly used in medicine) way to put a Pearson's correlation coefficient into (strong, medium, weak) categories?
[1] strong (0.7 - 0.89), medium (0.5 - 0.69), weak (0.3 - 0.49)
[2] strong (0.6 - 0.79), medium (0.4 - 0.59), weak (0.2 - 0.39)
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Ahmed Bakr, I can’t really comment, but it sounds reasonable! You could also classify them as “weaker” and “stronger”, implying that these are relative rather than absolute. Sometimes we get caught up in the statistics… try picking out one of the weak ones and try to understand what is going on in the real world, not from a statistical perspective - what is correlated with what, and what sorts of influences (in real life) might be weakening the relationship?
Best !!
AN
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Get in touch for more info.
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interested
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Casodex (or bicalutamide) is available only as a racemic mixture (S and R enatiomers): 1) the pharmacologically active R (-)-enantiomer, and 2) S-Casodex, the inactive (+) enantiomer. The S-enantiomer is thus the non-working compound but is also metabolized at a much lower rate. In other word, much higher plasma levels are the result. Does anybody know if casodex can increase emotional instability/anxiety? And which enantiomer is causing this?
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Re: anxiety as a side effect of bicalutamide
THIS IS FROM WIKIPEDIA [paraphrased and abbreviated]: Side effects due to androgen deprivation include mild-to-moderate breast tenderness and enlargement in up to 80% of men, along with feminisation. Reduced body hair and muscle mass, feminine fat distribution, reduced penile length, and decreased semen volume can occur, along with hot flashes, sexual dysfunction, depression, fatigue, weakness and anemia. Bicalutamide monotherapy has also been associated with an increase in the rate of heart failure.
MY OPINION: in view of this side effect profile, depression, anxiety and id-percieved stress, in a percentage of subjects, is to be expected.
Stress-related intracellular hypothyroidism (IC), producing CFS-like symptoms including anxiety, confusion and cognitive loss, will result.
Incidentally, cardiomyopathy resulting from IC is the probable cause of the heart failure mentioned in the Wikipedia article.
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I submitted my manuscript to one of the Lancet Journals. The status remained as “submitted to Journal” till mid February.After that it changed to “Decision in Process”. The status has remained so till April. I have also written to the journal thrice but did not receive any reply from them. I am very confused about the status of my manuscript. There seems to be no option to retract the manuscript too. My mentor is not allowing me to contact the Ombudsman.
I have previously submitted manuscripts twice to Lancet journals but they Would make an editorial decision within 3 days.
Is the current case just a technical glitch or are they pondering over my manuscript? What are the chances of a positive response from the journal based on my case? Also how do I go about the situation?
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I advise you to just be patient and be at rest since the decision is still in progress on your manuscript, it might end up in your favor
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I want to find some medicines which have the neuroprotection effects, as i hope that it has been researched in other diseases but not the field i am researching now. I know maybe i could find the suitable medicine if i have read many related papers, but is there another way to find it? Thanks.
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Dear colleagues, how is it possible to protect neurons, oligodendrocytes, any cell against injurious agencies that are poorly known, or if relevant evidence is not paid attention to, as shown at www.ms-info.net and in similar publications?
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Severe andor resistant chronic urticaria is a terrible disorder.
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I think that the best way is keep the house especially the room of the patients clean and healthy. Not dusty, full of ash, smoke residu, spider web, bad humidity, and other poluttants. Sun light and fresh air are also very important.
Housework is important to help this kind of case.
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Dear Colleagues,
A plant-based diet is a diet based on fruits, vegetables, whole grains, and legumes while a vegan diet is strictly against all animal products. Whats your openion about PBD and vegan and their effects on our health?
Thanks
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Healthy plant-based foods may lower risk and severity of COVID-19.
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I am working on my MSc dissertation, investigating breast protection bras for female boxers. I am looking at their protection but also the fit and shaping of them and how this relates to their comfort during wear. Is there any sort of classification of the shape of women's breasts? How would I describe the natural breast shape?
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Thank you
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Dear Researchers,
The recent changes in the COVID-19 epidemic have led to the emergence of a new SARS-CoV-2 Variant of Concern (VOC), named "Omicron," and the number of Omicron cases were consistently increasing around the world. The health professional's knowledge is of utmost importance to prevent and control the spreading of the SARS-CoV-2 Omicron Variant of COVID-19. In this regard, we would likely to know the level of knowledge and Perceptions of health professionals about the SARS-CoV-2 Omicron Variant; this can provide a greater opportunity to understand the existing knowledge gaps about the novel Omicron variant and to scale up the interventional strategies. Thus, I invite you to participate in this short survey and provide your
valuable opinion regarding the SARS-CoV-2 Omicron variant.
Thanking you in advance
Sincerely
Akshaya Bhagavathula
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What is the extent of bias risk between standard and autobiographical case reports in medicine and is there any medical journal (indexed or not indexed in MEDLINE) publishing or having a history of publishing autobiographical case reports?
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Besides the ethics, this case report can be controlled and criticized by others officially, in order to be approved.
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In the structure of many drugs, there is a carboxylic group
What is the significance of this group? Why should it exist in the structure of a drug?
Do you know any article or book or reference about this subject?
Thanks a lot
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Nalidixic acid - A NSAID grs of drugs or pain killer .REF : en.wikipedia.org ( Image Source ) .
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COVID-19 is mainly a respiratory disease that affects the lung, although other organ structures with endothelium seems to be affected too.
When should we do imaging?
What is the aim of the imaging?
How can it help with management?
Do you agree with the following consensus statement?
How will you adjust your own practice and difficulties encountered? Why?
Ref:
The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society. Chest. 2020 Apr 07.
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I personally believe that imaging examinations in covid should be rapid, simple and executable at the patient's bedside and therefore I believe that the most useful is LUS.
Unfortunately still today is used the chest X-ray that has been proven useless.
The purpose of LUS is to stage the pathology in order to predict its evolution, unfavorable or favorable. With LUS and blood gas analysis we can determine which patients should be discharged at home in a period when bed meals are scarce in all hospitals.
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What types of exercises and training variables (volume, intensity, repetitions, frequency, exercise selection, exercise order, and rest) are recommended for patients with Multiple sclerosis (MS)?
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Dear Hamidreza Khalounejad , there are various types of modalities that can be beneficial for persons with MS.
I have explained all types with detailed information such as volume, repetitions, exercise selection, etc particularly during COVID-19 in my latest article, which you can find it here:
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COVID-19 is changing the social life of all people. Jumping out of the personal aspect, how does it affect the family as a whole.
Family is regarded as the fundamental structure of the society, will COVID-19 changes the future family structure, unit and model?
How is it affecting gender issues too?
Besides, why is domestic violence increasing? Is psychology and psychiatry playing a role?
reference:
[1] Campbell AM. An increasing risk of family violence during the Covid-19 pandemic: Strengthening community collaborations to save lives.
Forensic Science International: Reports vol. 2 (2020): 100089.
[2]COVID-19: Reducing the risk of infection might increase the risk of intimate partner violence
EClinicalMedicine
[3]The pandemic paradox: The consequences of COVID‐19 on domestic violence
J Clin Nurs
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Dear Dr Sunny Chi Lik Au . See the following useful RG link:
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To be a better medicine what will we consider as chemically potential?? in terms of Chemical Reactivity of Targeted Drug Molecules with other potential molecules
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Dear Eleas,
If I understand correctly your question is with respect to the chemical reactivity of an NCE for its target.
Most commonly high chemical reactivity is not seen as an advantage. First the molecule needs sufficient stability for shelf life, limit impurities... Then reactivity may lead to safety issues if this leads to reaction with proteins other than your intended target. A variation on this theme is also formation of reactive metabolites that can cause liver toxicity; this is linked to the original molecule having reactive features or groups that are made reactive when oxidized (oxygenated).
However, reactivity towards the intended target can be very effective for inhibition from covalent binding. This can for example allow to decuple PK and PD (prolonged PD depending on target turn-over). For this to be effective it needs to be specific: reactive "warhead" reacts only with the intended target when molecule specifically bound and not with relevant off-targets. An example of this you can read about is remibrutinib.
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What are the conceptual bases for personalised nutrition?
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Agree with Deshmukh
I would include some othre ideas related to: reponses, intraindividual variabilitiy, taste, enjoyable, pleasure
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Does creatine supplementation increase insulin sensitivity?
What is your opinion?
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Evidence:
"Acute Cr supplementation (20 g.d(-1) for 5 d) followed by short-term Cr supplementation (3 g.d(-1) for 28 d) did not alter insulin action in healthy, active untrained men"
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Nanoparticles used
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@ Anwar, TiO2 nanoparticles is an effective microbicide agents, which have the advantage of improved safety and stability compared to organic antimicrobial agents. Titanium dioxide is also used in most sunscreens to block UVA and UVB rays. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups.
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Artificial intelligence is being used more and more in all medical fields. What do you think will be the development directions for the next 5 years?
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Expanded Disability Status Scale (EDSS) is a method of quantifying disability in multiple sclerosis that is the most widely used measurement tool to describe disease progression in patients with MS.
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Resistant exercises can tire MS disease quickly. This is an undesirable situation in patients with MS.
I recommend more ROM exercises and short-term isometric exercises.
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I have received the following polite email request from Medical Research Archives, European Society of Medicine a number of times.
Is it legitimate? Would you mind sharing your thoughts if you have any experience of this kind? Thanks
Dear Dr. Yegnanew A. Shiferaw,
If you have a few minutes I wanted to discuss your COVID-19 research. I am serving as the editor of a special theme issue on Advancements in COVID-19 which will be released by the European Society of Medicine next year and I was thinking that something related to your work on "Regime shifts in the COVID-19 case fatality rate dynamics: A Markov-switching autoregressive model analysis" would be interesting to include in the issue. Perhaps you could tell me more about your research in this area.
This could be in the form of a research article or even a review article.
Might this be a possibility?
Sincerely,
L. Smith, M.D.
Medical Research Archives
European Society of Medicine
Online ISSN: 2375-1924
Print ISSN: 2375-1916
PubMed ID: 101668511
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If we treat the animals for a certain period of time (ex, 4 weeks), how long time human should be treated for the same medicine?
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This depend on the drug bioavailability , way of excretion may be differ than that in animals all these should be taken in consideration
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If I have an experience but no certificate in Machine Learning, and have both experience and certifcate in Medicine (Urology) ... and want to publish a peper that include an interaction between these 2 feilds, in either Urology or CS journals. Should i add a coauthor who is certified in Data science or CS? ... if not, Would it be necessary to prove my competency in ML by any means?
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Publishing on a particular area does not require one to necessarily have a certificate in that area. However, if you find yourself to be inadequately equipped with the requisite knowledge to do a good job in that specific field, you may overcome that by collaborating with someone with that knowledge so that together you can bring out a very good and scientific work.
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Dear friends!
I hope you had a wonderful Christmas. Im very much interested in teaching and I would like to ask your views on a highly ( to me at least) interesting topic. There are probably as many methods of teaching methods as there are lecturers but here are