Medicine - Science topic

Can we use artificial intelligence technologies such as Machine Learning and Deep Learning to help in finding medicine or vaccine for COVID-19. Any ideas?

What are the most important factors to considered when thinking about the cities of the future? What scholars to involve? Or, can we even leave some academic discipline behind and not include them in discussion?

This is just a teaser for an upcoming conference...

Theology in Rijeka and the Department of Philosophy of the Catholic Faculty of Theology at the University of Zagreb, the Department of Social and Human Sciences in Medicine at the Faculty of Medicine of the University of Rijeka, the Faculty of Health Studies of the University of Rijeka and Faculty of Theology at University Nicolaus Copernicus, Toruń (Poland) - organize an international symposium, titled „The City of Future: Anxiety of Expansion“, which will be held on November 13, 2020 (Friday) in the Theology Building (Rijeka, Omladinska 14).

There are two theories that are quite similar in nature, but different in substance, The theory of Mind and the theory of Mentaliz(S)ation, sorry, Im allergic to American spelling...pls dont kill me now :-) My understanding of them is this "Both of these concepts, mentalization and the theory of mind, describes processes that are metacognitive in their nature . Mentalization mainly concerns the reflection of affective or emotional mental states. In contrast however the, theory of mind focuses on things epistemic in nature such as beliefs, intentions and persuasions. My idea is that these two theories by them self are incomplete but combining elements of both, gives us a clearer understanding. Cognition and affect can't in my view be separated, they are both part of us as human beings and also a part of other animals. What are your thoughts? Am I wrong or right? I can stand criticism so bring it on...

How weather can be a factor in Corona virus spreading? As Africa is still safe from it.

The situation is going worse and the health system in IRAQ is so poor to provide the simplest treatment needs of patients. What should we do in such a horrible situation?

Is there advice that should we follow to stay safe and healthy until they come up with the vaccine of COVID-19.

How to make our immunity stronger in this situation, what should we eat? what should we drink? what kind of medicine should we have to have at home?

Under COVID-19, healthcare facilities requests a lot of sterilization to prevent hospital transmission of the disease. Bleach solution and many other disinfection agents may not be effective against such a large scale of usage.

Can ultraviolet light be used to inactivate the virus?

Can it be applied on whole room disinfection?

Can it be used on high turnover medical equipment sterilization? E.g. stethoscope.

Can it be used to inactivate infected donors' blood products or body fluids?

What are different coil shapes used in Transcranial Magnetic Stimulation? What are their differences (in induced current)? Do they have different applications?

Many studies and analyes we do require statistics to back up. However, many times the results run out to be statistically significant, yet when interpret it in the clinical context, it is too small to be significant.

This is rather frustrating. Any solution for solving this?

Is those very small interval unit scale more easily affected?

Can we change our analytics method to cope with the results?

Beyond statistical significance: clinical interpretation of rehabilitation research literature.

Int J Sports Phys Ther. 2014;9(5):726–736.

I am interested in how people/cultures view specific foods as cures or treatments for illnesses.

Hello Colleagues

Recentrly, fungal infections cause an increase of morbidity and mortality in hospitalized patients and in immunocompromised persons. What are the most recent recommendations and guidelines for the control and prevention of nosocomial fungal infections.

Thanks

The background of my question can be ranged as: ''Quantum tunneling'' can be used by enzymes to transfer electrons long distance what can be the reason behind protein quaternary architecture evolution to sustain. Also quantum tunelling may be the reason behind DNA mutation along changing the forms of nucleotides. The reason of efficiency of photosynthesis may be to protect quantum coherence. There are also works about sensation and quantum mechanics. Such as the difference of molecular vibrations probably being detected by the olfactroy recepters that makes us to feel different smells, a small number of points across the retina detects single photons and these are decoded by a specific retinal map that makes us identify what we see and entangled radical pair mechanism also help to some animal to navigate theirself.

Considering these, maybe merging quantum mechanics and evolution can fill many gaps.

Hi everyone! I got an invitation to submit a paper to the following SCI-E/SCOPUS MDPI journal (special issue):

https://www.mdpi.com/journal/life/special_issues/advances_eHealth

The Article Processing Charge (APC) is 1400 CHF (Swiss Francs) per accepted paper. However, the fees will be fully waived (as it is an invitation to contribute) if I can submit the paper by the end of June 2020.

If anyone have a collaboration idea, please send me a message.

Hi all,

I am stuck at the following problem: I need to determine if there is a significant difference in Length of stay (LOS) in two groups: decendents and survivors, in different age groups. Can somebody help me with this? In a similar article I found they did use kruskal wallis to calculate this. Somebody some ideas to solve this in stata?

Thanks a lot!

You all are well aware that COVID-19 has disrupted every aspect of our lives including K12 and higher education sectors. Keeping in view the WHO recommendations, nations are enforcing social distancing in all fields including primary, secondary, higher secondary and university education. If we think positively, then this culprit COVID-19 is a blessing in disguise as the people are now taking care of personal hygiene, cleanliness of their surroundings and trying their best to improve their immunity. Besides educational institutions are reaching to the students.

During the past three months, the schools and universities around the globe have extended their outreach from a confined classroom to the students` bedrooms. Now the students can learn with more flexibility without wasting their times in travelling to their respective schools. The online mode of education has proven fruitful as it has lead to reduce institutional expenses which they had been spending on building & maintenance of infrastructure, electricity, furniture, multimedia and computing equipment. There is likelihood that tuition fee may be reduced with time if the situation prolongs (god forbid).

Apart from the above facts, I personally believe that online mode of education can not replace laboratory and clinical training of students who are pursuing their undergraduate studies in medicine, dentistry, engineering and such other technical fields.

People around the media are discussing the usage of facemask under COVID-19. ANd many evidence are available, yet no definite conclusion.

I have just gone through this study

Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients

Ann Intern Med. 2020.

DOI: 10.7326/M20-1342

What do you think?

Under the pandemic of COVID-19, screening becomes important to tackle the spread. Fever is one of the screening criteria for many public places screening for access.

However, how is fever defined?

Is the 0.1 degree change makes the significance?

What is the range of standard deviation being acceptable?

What machine is accurate?

Is those hand held infrared measuring machines reliable?

Is there scenarios giving false negative tha may make a huge consequence?

Normal Body Temperature: A Systematic Review.

Open Forum Infect Dis. 2019;6(4):ofz032. Published 2019 Apr 9.

aoa i have undergone analysis of differents researches if we reduced its reproduction by preventing pcr activity

Consider the following voluntary scheme. There would be some eligibility requirements that would be consistent with the principles of health promotion. Only certain target groups would qualify.

You sign up and for walking 10,000 steps per day, you get a certain amount of money deposited directly to your cell phone. In principle, and in theory, what is wrong with this? In practice, people could cheat and so on but with the development of new technologies, it would be much more difficult to cheat so this disadvantage can be minimized. The funds for this scheme could come from a public-private partnership.

This might be considered a worst case scenario.

Repeated strikes by such a virus would scythe defenseless new victims each time, leaving fewer and fewer survivors.

For the species to survive, humanity would have to evolve resistance or other means of survival.

Is such a virus possible?

How would its epidemic spread be modeled?

Has a virus like that occurred in the past?

How would we deal with such a virus in the future?

What strategies would defeat such a virus?

I am interested in how people and cultures view practitioners and supporters of Nutraceuticals. For generations, food or plant based substances have been used as a treatment for disease. The pharmaceutical industry has replaced grandma remedies. Charlatans have given the herbal drug industry a bad name. True believers of herbal cures though have also stretched the public's faith with cures for baldness to cancer and now to Covid-19.

It obvious that use of expired medicines where there are alternatives is unacceptable. There are, however, situations where the only available alternative medical product (medicine) used for life-threatening disease condition is expired and left with bare hands. What do healthcare professionals do on this situation, especially in this covid-19 pandemic where procurement is a challenge? Based on the risks-benefits assessment - the risk of leaving a patient without alternative and using expired medicine to save the patient and its associated risks - if they clinicians are going to use the product, what strategies they should follow to avoid medico-legal issues and transparency with consumers.

Looking forward to hear back from you?

Kind regards,

Mulugeta

Genome sequencing helps find vital information, for example the strain type, virulence, location of origin and differences between strains transmitted within the country and in other countries

I need two mammography datasets sourced by different counties or institutions where images are similar to each other.

I'm reading the International evaluation of an AI system for breast cancer screening released by google Jan-2020

PDF paper: https://www.nature.com/articles/s41586-019-1799-6.epdf?author_access_token=V_LKV2xpSv9G1dhANYeWM9RgN0jAjWel9jnR3ZoTv0M5zwPVx5jT4z_z-YkUZTBT6_1AtRXi8QouJM7xB-oSN-cVBoH7f_QTgx-yQN3UBEVfkvO1_5urNT-CZHGCEQNGlCuO69tMQYak4SmdoDqyzg%3D%3D

They used two datasets. One from the UK (OPTIMAM) which needs permission for use. The other from Northwestern Medicine which again needs permission to use.

Are there publicly available datasets that resemble the two above mentioned datasets? especially the OPTIMAM?

Can anybody help me to find out such website where i can find out solubility of any drug or medicine at one place?

COVID-19 is changing the social life of all people. Jumping out of the personal aspect, how does it affect the family as a whole.

Family is regarded as the fundamental structure of the society, will COVID-19 changes the future family structure, unit and model?

How is it affecting gender issues too?

Besides, why is domestic violence increasing? Is psychology and psychiatry playing a role?

reference:

[1] Campbell AM. An increasing risk of family violence during the Covid-19 pandemic: Strengthening community collaborations to save lives.

Forensic Science International: Reports vol. 2 (2020): 100089.

https://doi.org/10.1016/j.fsir.2020.100089

[2]COVID-19: Reducing the risk of infection might increase the risk of intimate partner violence

EClinicalMedicine

https://doi.org/10.1016/j.eclinm.2020.100348

[3]The pandemic paradox: The consequences of COVID‐19 on domestic violence

J Clin Nurs

FDA has issued guidance to provide recommendations to health care providers and investigators on the administration and study of investigational convalescent plasma collected from individuals who have recovered from COVID-19 (COVID-19 convalescent plasma) during the public health emergency.

The guidance provides recommendations on the following:

Because COVID-19 convalescent plasma has not yet been approved for use by FDA, it is regulated as an investigational product.  A health care provider must participate in one of the pathways described below.  FDA does not collect COVID-19 convalescent plasma or provide COVID-19 convalescent plasma.  Health care providers or acute care facilities should instead obtain COVID-19 convalescent plasma from an FDA-registered blood establishment.

what should be the ratio of sodium benzoate in preparing a herbal suspension ?

I was working for a project. The computational part is done. Now it's time to write a paper. But I am procrastinating much and actually I am not sure how to start or where to start.Which part should I write first? How can I accelerate the process.

Dear Colleaugues,

There was a proposal of a researcher who asked me to write down a paper which will more or less extend the poster (link bellow) published at ICCB 2016 in Prague. This all happened by an accident. I did not like to come at a conference without some presentation. Hence, I did quickly put the ideas that are resonating in my head for years on that poster to allow other researchers to benefit from it. Surprisingly, this poster is getting a great deal of attention. Therefore, I am thinking about to write down a review (prescription) how to design sel-organizing and emergennt systems with a rich example aparatus. If you like the idea then wisit the poster and let there a comment about it (bellow the poster).

The whole project is meant as a service to the community of biological and medical researchers who would like to know more but have no time to study mathematics and programming in depth.

All the best at your research,

Jiri

As we know that, every country will take a standard time to the approved patent of medicine, however in this pandemic situation, this will continue in the same process? Should we not consider the situational gravity for the greater good of humanity?

Conozco algunos centros comunitarios que trabajan con este tipo de medicina, y considero que parte de la sabiduría en ciencias de la salud parte de como se tratan las enfermedades actualmente en las comunidades de los pueblos nativos.

Dear Colleagues and researchers,

 We can start with writing a review or research paper if there are data about the following topics:  *Transmission modes of COVID-19 virus through environmental media, including air, water, soil, surfaces/interfaces, among others.

*Detection of COVID-19 virus in environmental media, such as air, surfaces, water, sewage water, among others.

You can share your ideas and contact me: alaa-mahmoud@alexu.edu.eg

Best regards

What does it even mean? Are you suffering from Empathy Deficit Disorder (EDD)?

In the age of Covid19, is there a basic conflict between science and superstition in the discipline of medical knowledge? Are there some simple, sensible, robust and reasonable ways to distinguish a scientific statement (or fact) from a superstitious statement?

To stay focused, the topic will concentrate on science versus superstition in the scientific discipline of medicine. We will try our very best to stay focused and not stray off track. it is very easy to wander off message and be all over the map. i will try to summarize the key conclusions from time to time.

In the age of the Corona Virus, there are so many statements out there. The statements may not be scientific. But if they are not scientific, are they false? Are they fake? Are they simply statements based on superstition.

What should we do if people believe in statements that are not based on science? Should we be polite and tolerate their beliefs?

As long as people do not harm others, then from society’s point of view, the fact that people hold non-scientific hypotheses is probably benign. However, the trouble starts when the same people act these beliefs, and then cause harm to others. The question arises: what should society do in this case?

Based on the discussion, there are two assumptions and four categories.

Assumption1: Beliefs cannot be justified or unjustified.

Assumption2: hypotheses can be disproven

Scientific hypotheses that are based on justified facts in natural causation. Or scientific hypotheses have not been disproven (I prefer the negative formulation because we may never be able to prove anything but we are unable to disprove it.)

Since science cannot give a definitive answer, there are many competing answers that merit our attention, and we may not be able to select among them.

Non-scientific hypotheses are unjustified facts that may be “proven” in the future with better evidence and facts.

Pseudo-scientific hypotheses: not sure where these fit in?

Superstitions are unjustified beliefs in supernatural causation.

WEIRD (Western, Educated, Industrious, Rich, Democratic)

Typically, WEIRD people have Western-influenced education. They are comfortable in international languages and have non-traditional values. Usually, they are young, hardworking, urban professionals with living and working experiences abroad.

What are the merits, if any, in the challenges that lawyers and economists have raised against the Covid19 lockdown? How much weight should society give to the opinions of epidemiologists?

In a patient with hereditary desminopathy (Thr341Pro DES mutation in a heterozygous state) with disease progression, a significant decrease in olfaction is noted. How can this fact be explained?

Some reports suggest that in the fight against Covid19, the use of ventilators have not saved lives. How do we assess these reports? Any merits?

Hi,

I am conducting a research project to see whether demographic/patient factors can predict patients who are likely to suffer a post-operative death (Categorical outcome Y/N).

I have conducted univariate regression procedure using SPSS Firths regression as I have a small sample size with the dependant variable being a sparse event. This has given me 3-4 variables with P<0.10.

DO I now proceed to perform a multi-logistic regression? If so, do I run Firths regression with all of these variables selected as co-variates or do I perform a more traditional multi-nominal regression model instead?

Any help would be appreciated as I can't find any guidance on this issue.

COVID-19 has pull people apart from each other. Social distancing is the main way to prevent spreading of infection. Tele-medicine, once used for rural area remote healthcare model, is the emerging new way of practice under COVID-19.

Different specialties have different practicing needs, what difficulties do you encounter on applying tele-medicine under COVID-19 in your specialty? Will tele-medicine totally uproot the usual face-to-face room consultation of medical practitioners? And becoming the new service model?

What is your view?

Some references:

Virtually Perfect? Telemedicine for Covid-19

NEJM

DOI: 10.1056/NEJMp2003539

Covid-19 and Health Care’s Digital Revolution

NEJM

DOI: 10.1056/NEJMp2005835

Telemedicine in the Era of COVID-19

The Journal of Allergy and Clinical Immunology: In Practice

DOI: 10.1016/j.jaip.2020.03.008

Keep Calm and Log On: Telemedicine for COVID-19 Pandemic Response.

DOI: 10.12788/jhm.3419

‘Healing at a distance’—telemedicine and COVID-19

Public Money & Management

DOI: 10.1080/09540962.2020.1748855

The Role of Telehealth in Reducing the Mental Health Burden from COVID-19

Telemedicine and e-Health

DOI: 10.1089/tmj.2020.0068

The World Health Organization (WHO) defines traditional medicine as "the sum total of the knowledge, skills, and practices based on the theories, beliefs, and experiences indigenous to different cultures, whether explicable or not, used in the maintenance of health as well as in the prevention, diagnosis, improvement or treatment of physical and mental illness". But some people believe traditional medicine is contrasted with scientific medicine.

What is your opinion? Can we use traditional medicine for treatment of COVID19? If your answer is yes, how do you want to do it?

There are news on COVID-19 outbreak on ship, no matter cruise or military one.

And few aircraft carriers are also involved.

What is special about the ship arrangement that facilitated all these?

Nature 580, 18 (2020)

Limiting spread of COVID-19 from cruise ships - lessons to be learnt from Japan,

QJM: An International Journal of Medicine, , hcaa092,

COVID-19 outbreak on the Diamond Princess cruise ship: estimating the epidemic potential and effectiveness of public health countermeasures,

Journal of Travel Medicine, , taaa030,

Public Health Responses to COVID-19 Outbreaks on Cruise Ships — Worldwide, February–March 2020. MMWR Morb Mortal Wkly Rep 2020;69:347-352. DOI: http://dx.doi.org/10.15585/mmwr.mm6912e3

Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020.

Euro Surveill. 2020;25(10):pii=2000180.

Describe impact of situation caused by pandemic of coronavirus COVID-19 on your Academic and Research activities.

Explain your action in a way to stay focused on Science and Preparing/Writhing/Publishing research.

It's 99 days since the first case of COVID-19 in Hong Kong, and we are welcoming the 5th days of 0 new cases of COVID-19 following a week of <10 cases per day.

How should we define the end of a local endemic?

How long should the latent period be defined?

When is it safe to resume social activities?

Should territory wide screening of asymptomatic people be done before declaring the end of endemic?

A famine of food does not necessarily mean that there is a shortage of food; it is the inaccessibility of food. Is it the same with the Covid19, in the sense that there is inaccessibility to medical resources?

after the colonization of vibiro choleraea in intestinal of human being than cause diarrhea after secretion of cholera toxin. in serious case how can stop that secretion?

Developing a vaccine is an important task. What is the best way to achieve this goal? Should we use a global competitive process?

Dear researchers

In your opinion, when is the peak number of cases of coronavirus disease (COVID-19)?

Academic journals publish original articles and higher level of evidence like review as their basis of survival. However, most journals also allow the manuscript type of "Letter to the editor" for readers in the field to reply previously published articles or on special events and issues like those once in a lifetime e.g. COVID-19.

As a researcher or author, do you think it is worth writing such a manuscript type?

Can you resubmit such "Letter" to another journal I'd being rejected?

Will you expect any citations from such "Letter"?

Will such "Letter" be externally peer-reviewed?

Is an underlying relationship with the editor an advantage of writing such "Letter"?

What do the editor expect you to write before accept your "Letter"?

Will "Letter" increase your h-index number?

There is no source of information on the acceptance rate of such articles.

Do you have any experience on the acceptance rate of such?

If such "Letter" is rejected, how will you handle the hard work with great effort paid?

How to write a letter to the editor that the editor will want to publish.

Can Med Assoc J. 1985;132(12):1344.

The virus is primarily spread between people during close contact, often via small droplets produced by coughing, sneezing, or talking. While these droplets are produced when breathing out, they usually fall to the ground or onto surfaces rather than remain in the air over long distances.People may also become infected by touching a contaminated surface and then touching their eyes, nose, or mouth. The virus can survive on surfaces for up to 72 hours. It is most contagious during the first three days after the onset of symptoms, although spread may be possible before symptoms appear and in later stages of the disease.

Is it fair and reasonable to say that in the medical sciences, English is widely accepted (universally?) by scientists as the main language for communication and defending research findings?

At this point in time, is this a valid statement?

Will this acceptance continue in the foreseeable future?

Hello Everyone,

I am searching for journal whose impact factor is at least 1 and that do not have article processing fee for publication. I am looking for journal related to medicine or diabetes/endocrinology. Thank you.

Some people claim that the people that need the vaccine the most are the least able to pay for the vaccine. Is this a correct claim? If yes, what should be the appropriate policy response?

The evidence suggests that the Covid19 virus jumped from bats to humans.

As a public health measures to control the spread of the pandemic coronavirus, social distancing and home quarantine are implemented in some countries.

As a matter of fact, patients are absence from clinic under COVID-19, and clinic-based diabetic control monitoring becomes challenging.

Do you expect a change in diabetic control for these patients when staying home?

They have less exercise, and may eat more snacks at home.

Or in contrast, they are too bored, and have time to develop new exercise without pressure from work? Besides, they are banned from social around, and may eat drink less alcohol and eat less feast.

What do you think?

What are the latest updates about the route of transmission and its impact?

Have you ever imagined how the physically disabled people feel under COVID-19?

Which type of disability is most impacting these minority under COVID-19?

Autism? Cleft patients? Mental health patients? Deaf? Dumb? Blind? Loss of limbs?

How can we help them?

The image shows surgical and gynaecological instruments used by ancient Egyptians over 3000-5000 years BC. It explains how advanced medicine at that time, scalpels, forceps, curettes were known and what we use as surgical instruments date back to ancient Egyptians designs. The question is, do you have a history of medicine in your medical/health curricula? What are the objectives of this component? And how do you integrate this part to other elements in the curriculum?

A milestone by Theodor Billroth in surgery and cancer surgery.

It is

- the 139th anniversary day (Jan 29, 1881)

performed

the first successful distal gastrectomy

for gastric cancer within 90 min

However, we may should be aware that everything in medicine surgery cancersurgery science needs teamwork

We are nothing without the Team!

COVID-19 is spreading around the world, and faeces were popular and agreed for the presence of viral RNA with different studies reported. Its presence mean that the gastrointestinal (GI) tract is one of the hosting organ for such coronavirus.

How are other parts of the GI tract system affected by this virus?

Reference:

Clinical features of covid-19-related liver damage.

Clin Gastroenterol Hepatol. 2020 Apr 10.

Pancreatic injury patterns in patients with COVID-19 pneumonia.

Gastroenterology. 2020 Apr 01.

Under COVID_19, most evidence and data are on adults, but more and more paediatric cases with some mortality are ongoing.

Let's gather all the paediatric related COVID-19 research here for referencing.

1) Yung CF, Kam K, Wong MS, et al. Environment and Personal Protective Equipment Tests for SARS-CoV-2 in the Isolation Room of an Infant With Infection. Ann Intern Med. 2020; [Epub ahead of print 1 April 2020]. doi: https://doi.org/10.7326/M20-0942

2) Brooks Samantha K, Smith Louise E, Webster Rebecca K, Weston Dale, Woodland Lisa, Hall Ian, Rubin G James. The impact of unplanned school closure on children’s social contact: rapid evidence review. Euro Surveill. 2020;25(13):pii=2000188. https://doi.org/10.2807/1560-7917.ES.2020.25.13.2000188

3) Dong L, Tian J, He S, et al. Possible Vertical Transmission of SARS-CoV-2 From an Infected Mother to Her Newborn. JAMA. Published online March 26, 2020. doi:10.1001/jama.2020.4621

4) Iqbal SN, Overcash R, Mokhtari N, Saeed H, Gold S, Auguste T, et al. An Uncomplicated Delivery in a Patient with Covid-19 in the United States. N Engl J Med. 2020 Apr 01.

DOI: 10.1056/NEJMc2007605

5) Qiu H, Wu J, Hong L, Luo Y, Song Q, Chen D. Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. Lancet Infect Dis. 2020 Mar 25.

6) Zeng H, Xu C, Fan J, et al. Antibodies in Infants Born to Mothers With COVID-19 Pneumonia. JAMA. Published online March 26, 2020. doi:10.1001/jama.2020.4861

7) Zeng L, Xia S, Yuan W, et al. Neonatal Early-Onset Infection With SARS-CoV-2 in 33 Neonates Born to Mothers With COVID-19 in Wuhan, China. JAMA Pediatr. Published online March 26, 2020. doi:10.1001/jamapediatrics.2020.0878

8) Chen D, Yang H, Cao Y, Cheng W, Duan T, Fan C, et al. Expert consensus for managing pregnant women and neonates born to mothers with suspected or confirmed novel coronavirus (COVID-19) infection. Int J Gynaecol Obstet. 2020 Mar 20.

I am interested in collaborating with any researcher working on modelling corona virus using fractional derivatives. If you are a researcher or you have a related project, please feel free to let me know if you need someone to collaborate with you on this research study. If you know someone else working on this research project, please share my collaboration interest with him.her. I would be very happy to collaborate on this research project with other researchers worldwide.

COVID-19 is in no doubt affecting every walks of life. Its impact towards every one and others' psychological and psychiatric health is significant, yet how should we quantify them?

Let's pull all related publications here for reference:

Understanding and Addressing Sources of Anxiety Among Health Care Professionals During the COVID-19 Pandemic

https://doi.org/10.1001/jama.2020.5893

The Mental Health Consequences of COVID-19 and Physical DistancingThe Need for Prevention and Early Intervention

https://doi.org/10.1001/jamainternmed.2020.1562

In my circle of friends there is a lively debate if corona is as dangerous as our media and governments is trying to portrait. Im one of those who doesn't believe Covid 19 is so much more dangerous to the general population than, lets say the flu. With that said I dont mean I would like to contract it, or any other illness. What is your take on the current situation? Is Covid 19 in your view something to be feared or do you like me view it as something that should not affect our lives and our economy to the extent it now has. How does your society handle the issue and what is your take? Best regards Henrik

Recently, I was conducted a quantitative analysis based on urban travel mode choices and national culture (Hofsede's culture dimensions) for 41 countries. The results showed that there are significant correlations, I presented several linear regression models which demonstrate travel mode choices can be predicted by culture dimensions. So I wondered if it can be related with evolution. The article is below:

Respiratory infections can be transmitted through droplets of different sizes: when the droplet particles are >5-10 μm in diameter they are referred to as respiratory droplets, and when then are <5μm in diameter, they are referred to as droplet nuclei. According to current evidence, COVID-19 virus is primarily transmitted between people through respiratory droplets and contact routes.2-7 In an analysis of 75,465 COVID-19 cases in China, airborne transmission was not reported.

Droplet transmission occurs when a person is in in close contact (within 1 m) with someone who has respiratory symptoms (e.g., coughing or sneezing) and is therefore at risk of having his/her mucosae (mouth and nose) or conjunctiva (eyes) exposed to potentially infective respiratory droplets. Transmission may also occur through fomites in the immediate environment around the infected person. Therefore, transmission of the COVID-19 virus can occur by direct contact with infected people and indirect contact with surfaces in the immediate environment or with objects used on the infected person (e.g., stethoscope or thermometer). 

Airborne transmission is different from droplet transmission as it refers to the presence of microbes within droplet nuclei, which are generally considered to be particles <5μm in diameter, can remain in the air for long periods of time and be transmitted to others over distances greater than 1 m. 

In the context of COVID-19, airborne transmission may be possible in specific circumstances and settings in which procedures or support treatments that generate aerosols are performed; i.e., endotracheal intubation, bronchoscopy, open suctioning, administration of nebulized treatment, manual ventilation before intubation, turning the patient to the prone position, disconnecting the patient from the ventilator, non-invasive positive-pressure ventilation, tracheostomy, and cardiopulmonary resuscitation. 

There is some evidence that COVID-19 infection may lead to intestinal infection and be present in faeces. However, to date only one study has cultured the COVID-19 virus from a single stool specimen.  There have been no reports of faecal−oral transmission of the COVID-19 virus to date.

Probiotics are live microorganisms that are intended to have health benefits when consumed or applied to the body. They can be found in yogurt and other fermented foods, dietary supplements, and beauty products.

Under COVID-19, many human activities are suspended, public entertainment places are closed down. Football legends are almost fully cut off worldwide.

The targets for gambler to bet are less and less, no matter football, horse racing, boxing, bar ...

How do the psychiatric addictive gambler coping with their addiction under COVID-19?

In psychiatry, psycho therapy or behavioral modification is always used. Is COVID-19 helping these addictive gambler to run out of their obsession?

Dengue fever is a disease caused by a family of viruses transmitted by infected mosquitoes. It is an acute illness of sudden onset that usually follows a benign course with symptoms such as headache, fever, exhaustion, severe muscle and joint pain, swollen lymph nodes (lymphadenopathy), and rash.

A hospital-acquired infection (HAI), also known as a nosocomial infection, is an infection that is acquired in a hospital or other health care facility. To emphasize both hospital and nonhospital settings, it is sometimes instead called a health care–associated infection (HAI or HCAI).

COVID-19 is putting a huge impact on the society by the isolation measures it brings. People are now working from home office, and every walks of life are pausing their usual work and life.

How about the booming exponential rise in COVID-19 researches? But a shut downed administrative team of the publishing office? And the loss of manpower towards battle over the. COVID-19 frontline?

With the limited journal space, will timely researches be delayed in publication? Which may miss out important messages towards the public!

Peer Review: Publishing in the time of COVID-19

DOI: 10.7554/eLife.57162

What's your view?

WHat do you think is the correlation? It's impact? and the possible transmission route?

Neurologic Features in Severe SARS-CoV-2 Infection

DOI: 10.1056/NEJMc2008597

Are immunity enhancer medicine (Homeopathic and Ayurvedic ) helpful to prevent yourself from Corona virus?

Hello!

I would like to understand in what cases blood or some other biological liquid passes through implant or graft with some porous microstructure according the Darcy law (thanks to the pressure differences).

I have an idea to produce a research about blood permeability through various implants microstructure, but unfortunately it is harder than I thought to found some justification in literature that blood actually could pass through such microstructure due the Darcy law. Thus, I would be grateful for your help in this question - maybe you have some papers about it or some other helpful stuff.

Sincerely, Catherine

In a paper deposited in BioRxiv entitled: "Susceptibility of ferrets, cats, dogs, and different domestic animals to SARS-coronavirus-2" the team from Harbin Vet Institute intentionally infected several species of animals including cats with SARS-CoV-2. The results showed that the virus was transmitted between the cats, but no sympthoms of COVID-19 were observed.

This result is interesting in terms of an observation made by a medic from Spain - Sabina Olex-Condor that from the 100 patients serious with COVID-19 that she examined there were no cat owners. She suggested as a hypothesis that due to cross-immunity (cats are a known reservoir of coronaviruses) cat owners have milder sympthoms of COVID-19.

I'm aware that the paper from Harbin Institute is a pilot study, has many possible dead ends and limitations. I'm also aware that this cross-immunity hypothesis suggested by Sabina need serious assement due to limited number (and problalbly non-representative set) of patients.

Do you think that this is possible in terms of knowledge of human immunology? If the above is met do any of you have access to indepth demografic (?) data of people infected with SARS-CoV-2 to check this hypothesis?

Disclaimer: not an expert in medicine or veterinary, I study plant genomics, this is pure scientific curiosity.

I hope that your families and friends are well.

Many journal publishers are opening their COVID-19 researches for free to the public. Among them which are the most useful? Is more famous one the better one?

If you got a research on COVID-19 on hand, which one of the following will you submit to ?

Which one is easiest to accept your publication?

Please vote as you like!

Other than those common opened platform below, you can also suggest any new ones you think is useful for COVID-19 research.

[1] https://jamanetwork.com/journals/jama/pages/coronavirus-alert

[2] https://www.nejm.org/coronavirus

[3] https://www.thelancet.com/coronavirus

[4] https://www.bmj.com/coronavirus

[5] https://taylorandfrancis.com/coronavirus/

[6] https://journals.sagepub.com/coronavirus

[7] https://www.elsevier.com/connect/coronavirus-information-center

[8] https://plos.org/covid-19/

[9] http://tools.ovid.com/coronavirus/

Many of us are doing ongoing prospective research, yet COVID-19 has paused our work for a while or even months because of the city shut-down. There is an unexpected huge increase in lost to follow-up in our research clinics.

How should we deal with these cases, and the associated data?

The selection bias caused by the lost to follow-up cannot be adjusted by study design, as it is started already. What methods can we use to adjust instead?

Can anyone simply explain how inverse probability-of-censoring weighted estimation technique work on this issue?

How to run it practically, e.g. by SPSS software? Or other higher level of statistical software is needed?

How about stratification-based methods or weighted methods? How are they working actually?

Any practical guide available online?

Great thanks in advance with all your help!

Ventilator is running out of supply under COVID-19, especially severely ill patients require non-invasive or even invasive ventilator support.

When there is outbreak of COVID-19 locally, physicians are facing the difficulties to choose between different patients for the allocation of limited medical resources.

Is there any simple way to turn something on hand to a usable ventilation machine? No matter household electronic gadgets, e.g. fan, vacuum cleaner, or existing medical equipment.

When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent particles, or virions, consisting of: (i) the genetic material, i.e. long molecules of DNA or RNA that encode the structure of the proteins by which the virus acts; (ii) a protein coat, the capsid, which surrounds and protects the genetic material; and in some cases (iii) an outside envelope of lipids. The shapes of these virus particles range from simple helical and icosahedral forms to more complex structures. Most virus species have virions too small to be seen with an optical microscope, about one hundredth the size of most bacteria.

I am involved in a post graduate programme in medicine. I observed but in all modules where self-directed learning has been applied, students are not progressing as expected. My thinking was may be our transition was not well done. Any input well-appreciated.

Regards

Prosper

Many efforts are spent to prevent, treat and stop COVID-19 spread.

but I think these efforts are fragmentary and not organized.

there is no platform for a scientific collaboration that could shorten the time of interesting findings, some nations hide some facts are a privilege of authorship or for other political reasons.

I think that all countries should a global platform for scientific collaboration.

Personally I have some ideas that could be proposed for the treatment of COVID-19 based on scientific facts but with the innovative mode of application, how and where can I try to apply them?

All nations should avoid wasting their time to find a solution for COVID-19 without international collaboration.

Dear Fellows

With the developing stories of the spread of COVID-19 all around the world, which has been declared as a pandemic by WHO recently, I am wondering, in how much time this virus would vanish from the surface of the Earth? Is there any scientific study available for this?

Please share your opinions.

till india is in second phase, as per world patient data india spreading rate is very low. but it may increase exponential. what you think about outbreak of corona virus in india.

Hi,

I am conducting a research project to see whether demographic/patient factors can predict patients who are likely to suffer a post-operative death (Categorical outcome Y/N).

I have conducted univariate regression procedure using SPSS Firths regression as I have a small sample size with the dependant variable being a sparse event. This has given me 3-4 variables with P<0.10.

DO I now proceed to perform a multi-logistic regression? If so, do I run Firths regression with all of these variables selected as co-variates or do I perform a more traditional multi-nominal regression model instead?

Any help would be appreciated as I can't find any guidance on this issue.

Viruses can not be killed. If so does a person infected from CoViD-19 doesn't acts as a carrier after his cure?

That is if a person is infected with CoViD-19 and he is been cured by the medicine, does he has that virus in his body in deactivated form? Or the body kills the virus by phagocytosis by the WBC's?

COVID-19 is affecting all kinds of human activities, research is not exempted. Many ongoing research studies are not paused because of COVID-19, patient recruitment cannot be continued, follow up visits are not stict to schedule, intervention procedures may be delayed, blood test monitor are postponed.

I would expect a higher loss to follow up rate during this period, which would affect the reliability of research. Even after COVID-19, will the recruited subjects have some difference than those recruited before?

What do you think?

I ruminated a consideration on this proposal for the last couple of days as Germany is in anticipation of the surge.

To be clear: This is also just a theoretical exercise and – if applied - would count as a desperate measure in the case of patients otherwise not being ventilated at all.

What if the mode of ventilation chosen would not be conventional BIPAP but APRV/inverse ratio PCV?

The control parameters correspond to conventional ventilator settings as follows: P-high (P-insp), P-low (PEEP), T-high (insp. Time), T-low (exp. time) and FiO2. Note that implementing this mode of ventilation with conventional BIPAP, which is possible in some devices, will in some setups require calculation of respiratory rate, which is 60/(Thigh+Tlow). The slightly different terminology as well as specific algorithms for implementation have been characterized and properly published by experts in the field – which I am NOT. There have been promising studies in ARDS which I will attach below.

If one assumes that for two (or more) patients the key treatment goal would be oxygenation with a more liberal approach to CO2 removal, it should be possible to choose P-high, FiO2 and to some degree T-low to achieve safe oxygenation margins for both patients. This would still allow for some inhomogeneity in compliance between the patients as the lung is splinted to a rather high point in the P-V curve by P-high resulting in a high resting volume. This is the proposed “open-lung” aspect of this ventilation mode. Nevertheless, due to the sparse and brief passive pressure relief phases it is believed to go without higher frequency repeated expansion like in conventional PCV, resulting in less energy deposition into the tissue. The repeated overinflation/atelectasis due to inhomogeneos P-V dependencies had been my main concern when thinking about PCV in a shared circuit and a possible result of volutrauma/atelectotrauma in the patients.

In case of inhomogeneous severity between the patients/different disease progression the treatment goal could be set for the more severe patient accepting hyperoxia in the “more well” patient. In terms of CO2 removal a “common ground” target for the patients could be set in wider range of acceptable values, opting for permissive hypercapnia. As the passive release of the lung volume to exhalation in T-low will generate outflow which is cropped at a certain level of peak flow (by setting T-low) when conventionally setting up/adjusting this mode, it might be difficult to assess this control parameter for the individual patient in a shared circuit.

APRV does even allow for spontaneous breathing on P-high in weaning approaches which have been proposed as well. If flow for the device serving two patients would be dialed high enough to compensate for potential maximum inspiratory peak flow generated by both patients in spontaneous breathing, it could be fathomable to even conduct weaning with two spontaneously breathing patients sharing the same circuit.

I write this as I feel we are all staring in a potential abyss, which might force us to make choices that neither of us ever wanted to make.

Hence, this is a THEORETICAL CONSIDERATION and not a recommendation. Also I do not take any legal responsibility if patient harm ensues. I hope everybody understands that. Also probably someone already thought of this. But I thought: Sharing is caring.

Take care and stay strong.

C

Cane RD, Peruzzi WT, Shapiro BA. Airway pressure release ventilation in severe acute respiratory failure. Chest, Aug 1991: 100 (2); 460-3 Fergson ND, et al. High-frequency oscillation in early acute respiratory distress syndrome. New England Journal of Medicine 2013, 368 (9), 795-804 Frawley PM, Habashi NM. Airway pressure release ventilation: theory and practice. AACN Clinical Issues, 2001: 12 (2); 234-246 Garner W, Downs JB, Stock MC et al. Airway pressure release ventilation (APRV). A human trial. Chest, Oct 1988: 94 (4); 779-81 Habashi NM. Other approaches to open-lung ventilation: Airway pressure release ventilation. Crit Care Med 2005 Vol 33, No. 3 (suppl.) Maxwell RA, Green JM, Waldrop J et al. A randomized prospective trial of airway pressure release ventilation and low tidal volume ventilation in adult trauma patients with acute respiratory failure. The Journal of Trauma, Injury, Infection and Critical Care, 2010: 69; 501-511 Modrykamien A, Chatburn RL, Ashton RW. Airway pressure release ventilation: an alternative mode of mechanical ventilation in acute respiratory distress syndrome. Cleveland Clinic Journal of Medicine, 2011: 78 (2); 101-110 Rasanen J, Cane RD, Downs JB et al. Airway pressure release ventilation during acute lung injury: a prospective multicenter trial. Critical Care Medicine, Oct 1991: 19 (10); 1234-41 Roy S, et al. Early airway pressure release ventilation prevents ADRS – a novel preventative approach to lung injury. Shock 2013, 39 (1), 28-38

Bickel (2009) describes those who remain robust under stress as resilient. Those who can rapidly adapt to change in times of stress are resilient. So, my question to you is, how are you? How are you coping? Are you thriving? Make sure you have seen this -> https://youtu.be/CCe5PaeAeew

Bickel, J. (2009). Faculty resilience and career development: Strategies for strengthening academic medicine. In Faculty Health in Academic Medicine (pp. 83-92). Humana Press.

Working in the research field, you will be weighted by your h-index.

However, publications might not be cited by others despite your hard work.

Do you think we should publish only citable research or publish as many as we could to contribute the academic field?

Yagyopathy question.

Why is the INDIAN GRANATE used in medicine. Do you know which medicines?

Does anyone know in which species the grass allergen Phl p5 occurs? It was originally isolated from the grass species Phleum pratense so it must at least occur in that species. It stand to reason that it might also occur in other species of the genus Phleum. A few papers states that it is universal in many grasses, but with poor documentation.

Can anyone provide conclusive evidence and/or references in which the authors state in which species (or cultivars) the allergen occurs and/or have been isolated from? I welcome answers from all researchers along with special interest from expert knowledge primarily from plant ecology, aerobiology, immunology and other health professionals.

Being invited to be reviewer for a conference or to be speaker is tempting for most young scientists. Not being aware of this businessplan I unfortunately accepted to review abstracts for one of such conference. Googleing around I realised I am not alone and that there are also several people wondering whether they should attend a conference or not as they are unsure if the organisers are genuine or not.

There are lists of predatory journals (e.g. https://predatoryjournals.com/journals/) but I did not find a good or comprehensive list of predatory conferences. So lets discuss such invitations to get a sense for those that can be trusted:

I am facing a problem when I try to calculate the hr from two different survival curves, here is the problem: in the first plot the experimental group's curve is more close to the placebo group then the second plot, even if the first plot's hr is smaller than the second plot. I wonder what the possible reasons are. Can you guys help me to solve this problem? Thanks.

Oncology is a branch of medicine that deals with the prevention, diagnosis, and treatment of cancer. A medical professional who practices oncology is an oncologist. The name's etymological origin is the Greek word ὄγκος (óngkos), meaning 1. "burden, volume, mass" and 2. "barb", and the Greek word λόγος (logos), meaning "study".

Cancer survival has improved due to three main components: improved prevention efforts to reduce exposure to risk factors (e.g., tobacco smoking and alcohol consumption), improved screening of several cancers (allowing for earlier diagnosis), and improvements in treatment.