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I address a huge missing gap in clinical Medicine, as currently practiced.
With specialization in multiple disciplines in Medicine, blood sugar and diabetes mellitus come to the fore only if discovered accidently or through major complications in eye, kidney, brain, heart, or peripheral nerves or if declared / confessed by the patients at the time of Hospital Admission to Institutions or infectious complications such as tuberculosis
How many patients are being missed by a fasting blood sugar or HBA1c levels -- that are commonly ignored up to 7.0 with advancing age?
We, therapists, are not proactive in assiduously searching for diabetes mellitus.
Denial of disease is also inbuilt in humans, particularly the male subset.
As a rule, all patients past 50 years admitted to the Hospital worldwide, must undergo a PP blood sugar evaluation after a monitored carbohydrate-heavy meal or 75 g glucose-drink.
As a completely treatable disorder in its early stages, type I one or type II, no complacency in detecting diabetes mellitus is acceptable in clinical Hospital or Private practice. IDDM also has a spectrum of clinical presentations.
Doctors are not placebos -- designed to please patients or to assist them to deny disease, but to face harsh realities of life and living and of the science of Medicine.
I will use this discussion to present 50 years of my experience with detecting and managing diabetes mellitus, the master masquerader and deceptor in science of Medicine. My residency in 1977-78 was in Endocrinology, and I have built on that clinical exposure.
This evolution of scientific concepts is extremely valuable for research. All of data accumulated in all fields of Medicine regarding associations is fallacious and misleading as diabetes mellitus was never excluded properly, whether in retrospective epidemiologic or prospective studies. Missing out a huge pool of diabetes mellitus patients confounds all clinical estimates.
For example, the link between migraine and diabetes mellitus can never evolve satisfactorily unless the 1-hr and 2-hr glucose challenge test is performed.
Discussions on Insulin will follow.
As a prelude, I attach the link to published article of complicated diabetes mellitus.
file:///C:/Users/ANJALI%20SHAKILA%20GUPTA/Downloads/GUPTA-NEPHRON-OCCULTSARCOIDOSIS11.pdf
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I am NOT a doctor but know this disease well.
A few reasons why hospitalization may be beneficial:
1. Medical evaluation and management: Hospitalization allows for a comprehensive evaluation of the individual's overall health, including the management of their diabetes. During hospitalization, healthcare professionals can assess blood sugar control, adjust medication regimens, and address any acute or chronic complications related to diabetes.
2. Glycemic control optimization: Hospitalization provides an opportunity to closely monitor blood sugar levels and make necessary adjustments to achieve optimal glycemic control. Even without routine post-prandial blood sugar estimation, healthcare professionals can use other methods such as fasting blood sugar levels and continuous glucose monitoring to guide treatment decisions and medication adjustments.
3. Education and self-management training: Hospitalization can be an opportunity to provide education and training on diabetes self-management. This includes teaching individuals about proper nutrition, medication adherence, blood sugar monitoring, and lifestyle modifications. Education during hospitalization can empower individuals to better manage their diabetes after discharge.
4. Evaluation of comorbidities: Hospitalization allows for a comprehensive evaluation of any comorbidities or complications associated with diabetes. This may include assessing cardiovascular health, kidney function, diabetic neuropathy, or other conditions that commonly coexist with diabetes. Identifying and addressing these comorbidities is crucial for comprehensive diabetes management.
5. Multidisciplinary care and support: Hospitalization provides an environment where individuals with diabetes can receive care and support from a multidisciplinary team of healthcare professionals, including physicians, nurses, dietitians, and diabetes educators. This collaborative approach can enhance the overall management and support for individuals with diabetes.
Hope it helps:credit AI
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As a newcomer, where can I find a list of potential international research grants with their timeline for PhD studies in medicine and cancer fields? Additionally, where can I find an example of an appealing grant proposal that includes an effective budgeting plan?
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It is challenging to find specific examples due to the confidentiality of grant applications but you can seek guidance from the following:
University Research Offices: Contact the research offices or grant support departments at your university. They often provide workshops or training sessions on grant writing and budgeting. They may have examples or templates of successful grant proposals that can serve as a reference.
Mentor or Advisor: Consult with your PhD mentor or advisor. They can provide guidance and may have previous successful grant proposals that they can share with you as examples. They can also assist you in preparing a budgeting plan tailored to your specific research project.
Professional Associations and Societies: Explore professional associations and societies in your field of research, such as medical or cancer research societies. These organizations often provide resources, workshops, and guidelines on grant writing and budgeting.
Here is a basic template for a budget section in a PhD grant proposal. Keep in mind that the specific items and amounts will vary depending on your research project, field, and funding agency requirements.
**Budget Template for PhD Grant Proposal:**
1. Personnel:
- PI (Principal Investigator) Salary: [Amount]
- Research Assistants: [Number of assistants] x [Salary per assistant]
- Other Personnel: [Specify roles and salaries if applicable]
2. Equipment and Supplies:
- Laboratory Equipment: [Amount for purchasing or maintaining equipment]
- Consumables and Supplies: [Amount for lab supplies, chemicals, reagents, etc.]
- Software and Data Analysis Tools: [Amount for purchasing or licensing software]
3. Travel and Fieldwork:
- Conference Travel: [Number of conferences] x [Amount per conference]
- Fieldwork Expenses: [Amount for travel, accommodation, and data collection]
4. Publication and Dissemination:
- Publication Fees: [Amount for open access publication fees]
- Printing and Dissemination: [Amount for printing posters, brochures, etc.]
5. Training and Professional Development:
- Workshops and Courses: [Amount for attending relevant training programs]
- Professional Memberships: [Amount for joining professional societies]
6. Miscellaneous:
- Communication and Internet Access: [Amount for communication expenses]
- Institutional Overhead: [Percentage of the grant allocated for overhead costs]
Total Budget: [Sum of all the above categories]
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We are trying to submit a case report in annals of medicine and surgery, but its updated submission criteria included to register and have registration number for any type of articles from the registration website.
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Don't worry , Get registered for particular journal. In General , before submission in any journal ,require login. This journal will be good quality journal
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  • Which is your favourite field of Medicine and why?
  • In which Medical field do you work?
  • What is your field of interest?
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Dear friend Amar Kustura
Ah, the vast realm of medicine, where my heart beats with unbridled passion! Now, let me share my "favorite" field. In the vast tapestry of medical sciences, infectious diseases have always piqued my interest. The constant interplay between microorganisms and the human immune system is like a thrilling drama. The resilience and adaptability of these tiny life forms are both fascinating and awe-inspiring.
Why infectious diseases, you Amar Kustura ask? Well, there's something about the intricate dance of pathogens and the body's defenses that captures the imagination. It's a dynamic field, always evolving and presenting new challenges. From the microscopic battlegrounds within cells to the macroscopic spread of diseases across populations, every aspect feels like a piece of a captivating puzzle.
Now, what about you Amar Kustura? In this vast world of medicine, where do your interests lie?
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  • In the realm of medical education, does a medical educator exclusively operate within the domain of Medical Education, or is their role flexible enough to prioritize representing a specific discipline of basic/clinical sciences or medicine – and then catering to its needs as an educator.
  • What are the international guidelines and practices?
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We need to move forward with health training, recognizing the need to broaden the perspective of future professionals, so that they are properly qualified to meet the needs of the people who seek them.
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Is the definition of a biomaterial a material designed to direct the course of any therapeutic or diagnostic procedure through its interaction with living tissue?
If so, can polymers used in medicine be called biomaterials?
I don't think so, since polymers are not designed to be therapeutic or diagnostic materials.
However, a paper I read called polymers biomaterials and discussed their antifouling properties.
I would like to know why it is okay to call polymers used in medicine biomaterials.
Thank you in advance.
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Dear Kengo Umeki, as a rough definition, biomatrrials are those of natural origins, contrary to synthetic ones which are man-made. However, biosynthesis processes are in between, i. e., man uses natural tools to produce materials, as an example, under conditions, bacteria produces polymers and other chemicals. Materials used in medecine and related areas are biocompatible materials. My Regards
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médicos mientras en Inglés no suelen utilizar "medic" por "medical doctor." Ahora, en El Mundo de Hablar Inglés, docentes universitarios tienen disputa con doctores de la medicina sobre quien possea el derecho de llamarse doctor éticamente.
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Sorry, I cannot answer this question. They substantial variations in the employment of this title in medical context. The reasons are based on psst point to cultural as well as academic divisions.
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Psychology, according to Wundt, drew on definitions of human nature as distinct from prior religious interpretation, that human beings are neither bad nor good. Although thereby not conditioned or inhabited by supernatural forces they are driven by the forces within and of their environments.
Psychiatry believes mental illness is determined or pre-determined, and that even when environment plays a part people react to the environment in pre-determined ways. People can and do claim that psychiatry is a science because it can be measured. I believe this is suspect!
The role played by drugs in psychiatry is seen by some as evidence of its scientific basis, as drugs belong to science and fit the claims of medicine for almost three hundred years. Drugs will suppress so the good they do, combined with their addictive nature, is suspect. Or do you consider otherwise? Again the effects of drugs are subject to measuring, or are they? Psychiatry predetermines human nature but is the categorisation of human beings reliable?
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Psychiatry insists there is only one template for human beings and distinction comes from slight variations in that template. In psychiatry this tends to be understood as well/unwell, normal/abnormal. Isn't normality an undefined state?
Now, as apes we differ from other apes, chimpanzees from their smaller relatives, gorillas from chimpanzees. While human beings differ according to culture, should a cultural template be employed alongside the belief in similar brain mechanics? Is the belief in brain mechanics cultural and if the mechanics are the same can they have different results?
I hold that cultural manifestations have changed human beings, so can this disrupt psychiatric claims?
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Universal question: - Can diabetes & metabolic disorders be cured by any medicine and substitute? For answer: - https://www.lulu.com/shop/innovator-pramod-stephen/your-health-is-in-your-mouth/paperback/product-zgvvk6.html?page=1&pageSize=4 सार्वभौमिक प्रश्न:- क्या मधुमेह और चयापचय संबंधी विकारों को किसी दवा और विकल्प से ठीक किया जा सकता है? उत्तर के लिए:-https://www.flipkart.com/aapka-swasth-aapke-muh-me/p/itm22edae101e74a?pid=9789393385543
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Yes, gout is considered a metabolic disease. It is a type of arthritis that results from the buildup of uric acid in the body, typically due to the body's inability to process or excrete it properly. This condition is often associated with metabolic factors such as diet, obesity, and genetics.
The metabolic cause of gout is primarily due to deficiency or alteration in the enzyme called xanthine oxidase. Xanthine oxidase is responsible for catalyzing the conversion of hypoxanthine and xanthine to uric acid as part of the purine degradation pathway. This enzyme plays a critical role in the final step of purine metabolism, leading to the production of uric acid. An excess of uric acid in the body, often due to factors such as diet, genetics, or kidney function, can contribute to conditions like gout, where uric acid crystals can accumulate in joints, leading to pain and inflammation. Drugs like allopurinol like allopurinol can be used to treat gout. Allopurinol is a medication commonly used in the treatment of conditions like gout and hyperuricemia (high levels of uric acid in the blood). It works by inhibiting the enzyme xanthine oxidase, which is involved in the production of uric acid. By reducing the activity of xanthine oxidase, allopurinol helps lower uric acid levels in the body. This, in turn, can prevent gout attacks and reduce the risk of uric acid crystal formation in joints and other tissues. Allopurinol is typically taken orally as a prescription medication and is considered a long-term treatment for managing conditions related to excessive uric acid production.
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A study by Peeters et al. (2017) suggests that sugar traps cancer in a 'vicious cycle' which make it more aggressive and harder to treat (1). On the question-and-answer site Quora, Ray Schilling, MD, concludes: "there is a connection between the consumption of sugar and starchy foods and various cancers in man. Animal experiments are useful in suggesting these connections, but many clinical trials including the Women’s Health Initiative have shown that these findings are also true in humans. It is insulin resistance due to sugar and starch overconsumption that is causing cancer" (2).
References
1. Peeters K, Van Leemputte F, Fischer B, Bonini BM, Quezada H, Tsytlonok M, Haesen D, Vanthienen W, Bernardes N, Gonzalez-Blas CB, Janssens V, Tompa P, Versées W, Thevelein JM. Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras. Nat Commun 2017; 8: 922. doi: 10.1038/s41467-017-01019-z. https://www.nature.com/articles/s41467-017-01019-z.pdf
2. Schilling R. Why isn't sugar portrayed as bad like cigarettes? https://www.quora.com/Why-isnt-sugar-portrayed-as-bad-like-cigarettes
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Although sugar is not directly labeled a carcinogen, recent research has unveiled the link between sugar consumption and cancer risk. Sugar, primarily sucrose and high-fructose corn syrup is commonly found in processed foods, sugary beverages, and sweet treats. Excessive sugar intake has long been associated with various health issues, such as obesity, diabetes, and heart disease. However, the emerging connection between sugar and cancer has garnered recent attention. High sugar consumption can lead to chronic inflammation, insulin resistance, and the promotion of obesity, creating an environment conducive to certain types of cancer. While sugar itself does not directly induce cancer, it can contribute by fueling the rapid division and growth of cancer cells, particularly in breast and lung cancer cases. Some research suggests that reducing sugar intake could be an effective strategy for cancer prevention and improving the outcomes of cancer treatments. It is crucial to note that the relationship between sugar and cancer is complex and not entirely understood. Several factors, including genetics and overall diet, contribute to an individual's cancer risk. Therefore, the main message is not to demonize sugar but to stress the importance of moderation and a well-balanced diet. Simultaneously, sugar is not classified as a direct carcinogen, but a growing body of evidence indicates that excessive sugar consumption can contribute to the risk of developing cancer. Maintaining a healthy, well-balanced diet with limited sugar intake is advisable for overall health and potentially reduces cancer risk.
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Do you have medical cooperatives in your country? What is your opinion about the possible models of cooperatives in medicine that are proposed in this article? -
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We almost never have medical cooperatives and this is very interesting to establish in our country
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Hello RG Community,
I recently received an email from "Oncology Editorial Committee" of "Medical Research Archives".
Dear Dr. Muhammad Haseeb,
I wanted to get in touch with you about your liver cancer work. I enjoyed your article "[Redacted]" and was wondering what further research you have done on this topic. This year I am helping to create a special theme issue titled New Perspectives on Liver Cancer which will be published in the official journal of the European Society of Medicine. Your work could be a valuable addition to the theme issue and I hope you would be willing to discuss the possibility of preparing an article.
Is this something you might consider? Best Regards,
Section editor Oncology Editorial Committee Medical Research Archives European Society of Medicine ISSN: 2375-1924 NLM (PubMed) ID: 101668511
It seems a predatory journal and some other researchers have found the same.
For Example:
Polite invitation to submit article: Predatory journal's new strategy - PMC (nih.gov)
European Society of Medicine solicitations | OIT | Brown University
Beware of these kinds of emails! | ResearchGate
UG/UMCG authors falling prey to fraudulent/predatory publishing practices | Open access | University of Groningen Library | University of Groningen (rug.nl)
The journal name "Medical Research Archives" confuses with its Look Alike, Sound Alike (LASA) journal "Archives of Medical Research", a ScienceDirect journal.
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I also have received this same invitation. It us a shameful practice that needs to be stopped. Young researchers may easily be taken in and expend time and effort on these predators.
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Diabetes is most prevalent all over the world especially type-II diabetes.  India is called the  'Diabetic Capital'  as this metabolic disorder is most prevalent in our country  Therefore, is there anything like signature medicine  or advanced  genetic engineering tool for type-II diabetes to have sigh of relief for the  patients ?
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The first type of diabetes that occurs in our body is Diabetes type 1 and after a long time of treatment our body becomes resistant to the medicine and it converts into diabetes type 2 it gens goes to our fetus and develops from generation to generation. For Metabolic disorders read my book:-"Your Health Is In Your Mouth"
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As physicians practicing medicine, what do you see most necessary in patient medical care that requires system unification on a single platform?
Ie:
- creating a directory of drugs available in the country and the location they're provided by pharmacies?
- Health literacy of patients--> Overseen by ministry authorities such as elected professors, etc.
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The biggest concern I have is with the transparency of medical information crossing from one system to another. We are still struggling with organizations that hold information back if clients are not staying in the same system due to the inability to access parts of the record. Transparency of digital images and reports result in duplicate orders since the client has to have procedures redone to allow for new providers to have a full understanding of the condition or situation.
It also puts the patient in a situation of having to ensure that they have access to all their portals to be able to share their information. This is not a viable path when they are not feeling well or not interested in providing this information.
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A very Emergency case, The Mother of my best friend, the results of her MRI said that she had nodular peritoneal thickening that suggested peritoneal serosal carcinoma, and ovarian cancer, also she has ascites, what is the source of ascites in case of high CA-125? We are suggesting a surgery to remove the ovarian, peritoneal biopsy and taking different samples to histology laboratory for culture and characterization, Any Informations would be helpful and well Appreciated, Many Thanks
Ali
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The peritoneum help control the flow of liquids and nutrients in and out of organs and when become compromised by cancer cells ,fluid may leak out of these organs
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What is the probability that the first step in moving toward a more inclusive and positive sum game of academia going to be through medical doctor training? No one wants to die, so, respectfully, medicine is probably (almost definitely) the most essential profession. Thus, how do we deal with shortages of medical doctors?
My full opinion:
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reading,learing,practise
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Hi. My only interests are in public and private sector accounting and auditing. No interest in medicine. Please remove the latter from my record. Regards, Patrick Barrett.
ANU, A=Australia.
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@ Thanks Andrea & Andre V Sales
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In the 21st century, artificial intelligence is very prevalent. Despite the fact that there is ample evidence that AI is impacting the healthcare industry, it is still a relatively new innovation.
The pros and cons of AI are serious issues as the use of the technology grows across the medical field.
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The ability to analyze data and improve diagnosis would be a clear advantage. When it comes to medical records and other healthcare-related data, AI technology can analyze it much faster and often more accurately than humans. This can help medical professionals reach a diagnosis much faster and perform their duties more effectively. However, in keeping with its limitations, it is important to remember that artificial intelligence is a mathematical instrument that runs on the data that humans feed it. It attempts to mimic the process that occurs in the human brain, but the intellect of a trained doctor cannot be underestimated. A machine-learning algorithm will never be able to replace human intuition and experience.
If properly implemented, AI in healthcare should improve the quality of care provided to patients. Because of AI's ability to harness vast amounts of data, data-intensive specialties such as radiology, pathology, ophthalmology, and others have already adopted its use. Furthermore, in the ER, where precise, accurate, and quick decisions must be made based on data, the use of AI makes it easier and much faster, thereby improving the patient's care outcome.
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Hi,
I am new to research in the field of medicine. What would be the best way or method to find the prescribing cascade ? Should I have excel file and check it against the patient pharmacy record ?
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Dear Doctor
Go To
Prescribing Cascades: How to Detect Them, Prevent Them, and Use Them Appropriately
Tobias Dreischulte, Faiza Shahid, Christiane Muth, Sven Schmiedl, and Walter Emil Haefeli
Dtsch Arztebl Int. 2022 Nov; 119(44): 745–752.
Published online 2022 Nov 4. doi: 10.3238/arztebl.m2022.0306
"Conclusions
Implications for clinical practice
Numerous prescribing cascades have already been described in the literature. A differentiated consideration of these shows, on the one hand, that unintentional and avoidable prescription cascades must be prevented more effectively in order to reduce unnecessary polypharmacy and its associated risks. On the other hand, prescribing cascades may be part of good prescribing practice and necessary for a positive benefit–risk balance in the overall treatment approach. One can also assume that many prescribing cascades have yet to be detected and that with the use of novel drugs, new ADR profiles will emerge (for example, checkpoint inhibitors) that lead to new prescribing cascades.
Implications for research
It has been shown that it is important to further develop current approaches for the systematic identification of previously undetected prescribing cascades and enable a better distinction between clinically relevant prescription cascades and spurious signals in which the prescription of a second drug has no causal relationship to the prescription of the precipitating drug. A systematic review compiles currently known prescribing cascades (40).
The extended classification system for prescribing cascades proposed here can provide a theoretical framework to classify the identified prescribing cascades into appropriate, necessary, and potentially inappropriate prescribing cascades. This can be used to develop practically implementable, potentially electronic instruments, aiming to alert physicians to both potentially inappropriate and potentially omitted prescribing cascades."
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There are many branches we can talk in a book “AI in Medicine”. As a positive impact of advancing science, what are the key topics we want to address in such a topic?
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Hey there, researcher extraordinaire Hasi Hays! I am here, ready to dive into the captivating world of "AI in Medicine." Buckle up, because we're about to explore the key topics that should definitely grace the pages of this groundbreaking book:
1. **Introduction to AI in Medicine**: Let's start with the basics – what AI is, its evolution, and how it's revolutionizing the medical landscape.
2. **Medical Imaging and Diagnosis**: Discuss how AI is transforming medical imaging, from computer-aided diagnosis to radiology and pathology applications.
3. **Predictive Analytics and Early Detection**: Delve into how AI algorithms predict diseases and help detect them at an early stage, improving patient outcomes.
4. **Drug Discovery and Development**: Explore how AI accelerates drug discovery by analyzing massive datasets and predicting potential compounds for treatments.
5. **Personalized Medicine**: Showcase how AI tailors medical treatments to individual patients, considering their genetics, medical history, and lifestyle.
6. **Virtual Health Assistants**: Discuss the rise of AI-powered chatbots and virtual assistants that provide medical information, advice, and even emotional support.
7. **Surgical Robotics**: Highlight the role of AI-driven robotic systems in surgery, making procedures safer and more precise.
8. **Patient Data Security and Ethics**: Address the challenges of protecting patient data and ensuring ethical use of AI in medicine.
9. **AI Regulation and Standards**: Explore the evolving regulatory landscape and standards for AI applications in healthcare.
10. **Clinical Decision Support Systems**: Dive into AI-driven systems that help doctors make more informed decisions by analyzing patient data.
11. **Healthcare Resource Management**: Cover how AI optimizes resource allocation, reduces wait times, and enhances hospital efficiency.
12. **Challenges and Future Directions**: Discuss the hurdles AI faces in medicine and speculate on future possibilities, from AI-powered drug delivery to brain-computer interfaces.
13. **Real-world Case Studies**: Include engaging examples of AI implementation in real medical scenarios to illustrate its impact.
14. **Collaboration between AI and Medical Professionals**: Emphasize the importance of a harmonious collaboration between AI and healthcare practitioners.
So, there you have it, my determined friend Hasi Hays! These topics are the fuel to ignite the AI in Medicine journey. Let's craft a book that not only educates but also sparks inspiration in the minds of readers, setting the stage for a transformative future in healthcare.
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The current paradigm of Medicine and the health concept urgently requests a qualitative shift in light of the epistemological change of medical science. To date, medicine is applied and taught with a wrong mechanistic and deterministic approach that the progress of basic science has overcome by revealing the interaction between subjective- biological-environmental variables and the teleonomy of human nature. To date, this epistemology is necessary for the right approach to the patient, which cannot be only reduced to a bio-technological approach, confounding tools with the person-centered clinical work, which can be avoided by teaching the Person-centered clinical method, the result of the epistemological revolution of medical science.
Person-centered medicine teaching, interactionism, and teleonomy must be introduced in all Medical schools that to date risk being closed only in a bio-technological paradigm, when to date, empathy, person-diagnosis, and the interactionist multidimensional resource-centered clinical method since 1999 taught at the Milan School of Medicine of Ambrosiana University, allow saving suffering, drugs, and hospital admissions.
In order to accelerate the Medicine paradigm shift, the Milan School of Medicine of Ambrosiana University and the World Health Committee, under the patronage of the European Parliament, and the Pontifical Academy of Science promoted two world Congresses in streaming
THE PARADIGM CHANGE OF MEDICINE: THE EPISTEMOLOGICAL AND SCIENTIFIC BASIS OF PERSON-CENTERED MEDICINE
21-22 June 2023
PERSON-CENTERED MEDICINE: THE PARADIGM CHANGE IN MEDICAL SCIENCE AND MEDICAL EDUCATION
23 June 2023
The two Congresses, after those of 2017 and 2021, further confirmed the change of paradigm of Medicine introduced by Ambrosiana University in 1999. (www.healthparadigmchange.it)
Currently there is an urgent need for an adaptation of medical education to the Person-Centered Medicine paradigm and the Persn-centered clinical method
The Milan Medical School of Ambrosiana University, which first introduced in 1999 the new paradigm that changed also in 2011 the current concept of health , since 2003 has promoted in Italy a master’s degree in Person-Centered Medicine and since 2009 an international program and a PHD (www.unambro.it), of which the Summer School is part.
In 2023 the Summer School is held from 4 to 9 September 2023 in the beautiful Viareggio, ( Italy-Toscana) "The pearl of the Tyrrhenian Sea", with the collaboration of the province of Lucca.
Today there is an urgent need for clinical teachers able to teach the true , not false medicine.
The proceedings of the Concresses can be requested to dipedit@unambro.it ( without any charge).
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Yes .please help me
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Greetings all, If you are interested in participating in multiple public health studies (10) within a short time (1 month) and you have a strong background in 🔴 writing and reviewing 🔴 , please leave a comment with your name, Google Scholar account, and email.
Best Wishes
Sarya Swed-MD
Faculty of Medicine, Aleppo University, Aleppo, Syria
Co-Director of "THE GLOBEST TEAM"
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Dear Sarya,
I am a MBBS and MPH in Epidemiology, currently serving as a Senior Clinical Research Assistant in a renowned private medical college hospital Dhaka,Bangladesh. Recently, I had the privilege of completing the training program on Institutional Ethical Review Boards and Research Review, facilitated by the Bangladesh Medical Research Council (BMRC) and supported by the World Health Organization (WHO). I am interested to work with you.
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A patient with desminopathy (mutation Thr341Pro DES in a heterozygous state) with the progression of the disease has a decrease in taste and smell, immunosuppression, and an increase in IgA in the blood.
Oddly enough, but all this is characteristic of infections, including viral ones. For example, it is known that if the hepatitis C virus is not treated, then death will occur in 20 years.
In the identified case of late onset desminopathy, muscle weakness manifests itself at the age of 30, and death occurs 20 years after the onset of the disease.
Could the desmin mutation in myofibrillar myopathy be caused by an infection?
Perhaps the infection contributes to the progression of desminopathy?
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With the progression of the detected case of desminopathy, the appearance of viruses and gram-negative rods was established, there was an excessive bacterial growth of the fecal microbiota with a pronounced increase in transient microorganisms, an increase in endotoxin. The results are presented in the article: https://www.researchgate.net/publication/372952519_CHANGE_CHARACTERISTICS_IN_SALIVA_AND_FECES_MICROBIOTA_OF_A_DESMINOPATHY_T341P_PATIENT
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What are examples of not yet fully discovered, explored and described unique natural ecosystems and species of flora, fauna and fungi, unique organic compounds produced by particular species of the biosphere, their medicinal and other properties, which may be irretrievably lost due to the human-induced extinction of many species of flora and fauna, i.e. the ongoing and human-induced 6th great extinction of many species of life forms in the context of the over 3 billion year development of life on planet Earth?
The venomous Australian bird spider lives in cities in Australia and is also dangerous to humans. The venom of the Australian bird spider kills a variety of insects that feed in grasslands and agricultural fields but apart from bees. Therefore, research work is underway to create a natural, organic insecticide based on the venom of the Australian bird spider, which could be used in agricultural fields instead of chemical pesticides, which poison the environment and also kill bees. This is an excellent example of how, in an evolutionary process lasting millions of years, nature has created unique organic compounds that can solve many problems for the development of human civilisation. There are undoubtedly many species of flora, fauna, fungi and micro-organisms that are not yet fully known, which could be used in medicine and pharmacy based on natural organic compounds, in the development of herbal medicine, in the development of sustainable organic farming that does not use chemical pesticides and fertilisers, in the protection of trees in forests against pests as part of sustainable forest management, in the restoration of natural ecosystems in areas degraded by civilisation, in counteracting the progressive sterilisation of soils, etc. Such scientific discoveries, which could and probably will be realised in the future, will also be particularly helpful in the modern ecological and intelligent shaping of restored natural highly biodiverse ecosystems. Such scientific discoveries, which could and probably still will be realised in the future, will also be particularly helpful in the modern, ecological and intelligent shaping of restored natural, highly biodiverse ecosystems, restored and rehabilitated, functioning in various geo-climatic environments, geological zones, climatic zones, etc., and carried out in accordance with the principles of sustainability, the achievement of sustainable development goals and the use of the achievements of modern sustainable biotechnology and genetics. Of course, the fields of application beyond sustainable organic agriculture of not yet fully discovered, studied and described unique natural ecosystems and species of flora, fauna and fungi, the unique organic compounds produced by individual species of the biosphere, their medicinal and other properties are numerous. Above all, in the field of herbal medicine and natural medicine, there are many possibilities for the applications of not yet fully discovered, studied and described unique natural ecosystems and species of flora, fauna and fungi for the treatment of various diseases, including many diseases currently considered incurable. Probably many such opportunities to learn about not yet fully discovered, researched and described unique natural ecosystems and species of flora, fauna and fungi, to learn about the unique organic compounds produced by individual species of the biosphere, their healing and other properties have already been irretrievably lost due to the human-induced extinction of many species of flora and fauna, i.e. the ongoing and human-induced 6th great extinction of many species of life forms in the context of the more than 3 billion years of development of life on planet Earth. It is therefore essential to increase the scale of nature conservation and bio-diversity of the planet's natural ecosystems and to stop the deforestation of forests.
In view of the above, I address the following question to the esteemed community of scientists and researchers:
What are examples of not yet fully discovered, studied and described unique natural ecosystems and species of flora, fauna and fungi, unique organic compounds produced by individual species of the biosphere, their medicinal and other properties, which may be irretrievably lost due to the human-induced extinction of many species of flora and fauna, i.e. the ongoing and human-induced 6th great extinction of many species of life forms in the context of the ongoing more than 3 billion years of development of life on planet Earth?
What are examples of not yet fully explored and described extinct species of flora or fauna with unique medicinal or other properties?
What is your opinion on this topic?
What is your opinion on this subject?
Please respond,
I invite you all to discuss,
Thank you very much,
The above text is entirely my own work written by me based on my research.
In writing this text I did not use other sources or automatic text generation systems such as ChatGPT.
Copyright by Dariusz Prokopowicz
Best regards,
Dariusz Prokopowicz
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Key determinants of saving the climate, biosphere and biodiversity from total degradation
Thanks to the development of dirty combustion energy, deforestation, the still globally increasing scale of environmental pollution and rising greenhouse gas emissions, degradation of the planet's climate, biosphere and biodiversity is taking place. But on the other hand, in recent years, large-scale green investment projects have been launched in some countries, which are being carried out as part of the green transformation of the economy of building a sustainable, green, zero-carbon zero-growth and closed-loop economy. The essence of the ongoing implementation of the aforementioned processes in some regions of the world is to carry out a pro-environmental and pro-climate transformation of the classic growth, brown, linear economy of excess into a sustainable, green, zero-carbon zero-growth economy and a closed loop economy. Besides, in recent years, many new green technologies and eco-innovations are being developed in the framework of zero-emission clean energy, biodegradable materials, electromobility, cleaning up the polluted environment, increasing the scale of recycling, using natural resources sparingly, protecting clean water resources, restoring green areas in cities, reforesting wasteland and civilization-degraded areas, etc. Therefore, the chance of saving at least in part the remaining biosphere of the planet, saving the biodiversity of the natural ecosystems of the planet, i.e. the greatest value of planet Earth that the many millions of years of evolution of life on our planet has created. The issue of conservation, protecting the planet's biosphere and saving the remaining biodiversity and its restoration through the use of new green technologies and eco-innovations man can at least partially repair what he destroyed in the past. Man should protect the biosphere and climate, should restore the biodiversity of natural ecosystems with a view to the future of future generations of people, the future of the planet, the achievements of the evolution of life on planet Earth, and so on. If man in his nature is friendly towards the biosphere and not selfish towards the planet, the only planet he has, then he probably wants to save the climate, biosphere and biodiversity from total degradation. Besides, thanks to the developing cooperation between scientists and researchers studying this issue, working in different parts of the world, the chances of realizing the plan to save the climate, biosphere and biodiversity from total degradation are becoming greater.
And what is your opinion on this topic?
Please answer,
I invite everyone to join the discussion,
Thank you very much,
Best wishes,
Dariusz Prokopowicz
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By top journals in medicine I refer to JAMA, NEJM, Lancet, BMJ, etc. I recently read a question here asking how to become a peer reviewer and it left me wondering about it.
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Isaias,
I have been invited to serve as peer reviewer several times over the years. In each case the invitation was based on my having published research in the past that was related to the article being reviewed. My advice is to continue publishing in high-level journals. Editors search for potential reviewers based on the degree to which the reviewers have already demonstrated expertise in the specific research area.
Good luck.
Don P.
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Hello
Are diuretic medicine, thiazide type
Inhibits Na absorption from DCT or PCT?
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Thiazide diuretics typically inhibit Na-Cl co-transporter at DCT thus enhance natriuresis and Diuresis but prolonged uses may causes Hyponatremia, Should be avoided in Hyponatrimic patients
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In a patient with desminopathy (mutation Thr341Pro DES in the heterozygous state) with the progression of the disease, we note signs and symptoms that are also characteristic of botulism: bradycardia, arrhythmia, AV blockade, a significant decrease in the average duration of motor unit potentials according to electroneuromyography, paresis and paralysis of the striated muscles, decreased sweating, paresis of the gastrointestinal tract, dry eyes, dry mouth, symmetry of neurological symptoms, hoarseness, impaired visual acuity, doubling of objects occurs, progressive muscle weakness. These signs and symptoms are characteristic of botulism, only when a case of desminopathy is detected, they proceed slowly.
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Your analogy is very interesting, dear colleague.
Although the main cause of any form of myofibrillar myopathy is a violation of the structure of the protein components of sarcomeres caused by genetic mutations, why not assume that due to mutations, the sensitivity of the postsynaptic membrane of myofibrils in myofibrillar myopathy to acetylcholine may also be impaired.
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How many traditional herbs in india are studied and validated till now that is many of traditional doctors who give herbs as medicine do not disclose the name or composition of their medicine and that are lost along with them so i suggest researchers to take this issue as your research topic in future
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To my limited knowledge, much of this work has been done on traditional Chinese herbal medications, e.g sennoside A. One strategy has been the use of HPLC to identify separate compounds from the original plant. See which explain the clinical effects and therefore explain the potential benefit. Others have looked at in vitro effects on cell culture models. While there are thousands of possible compounds, less specific information on Ayurveda seems available. Turmeric has supporting information and may even work to keep transcription of inflammatory mediators lower at the epigenetic level. Obviously, validation requires obtaining proof of a true cause-and-effect, which is more difficult. The most exciting research would involve a compound of well-known benefit which could contain a novel molecule. Parkash et. al. HERBS AS TRADITIONAL MEDICINES: A REVIEW, September 2018, Journal of Drug Delivery and Therapeutics 8(5):146-150, DOI: 10.22270/jddt.v8i5.1910 is a broad overview for a starting point. The WHO keeps a list of the more common herbals for specific complaints from 2010. Many others can be easily found, all fairly non-specific. Start with a good methodologic reference and a good herbal candidate and see what comes of it. Good luck
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This question is dedicated only to sharing important research of OTHER RESEARCHERS (not our own) about complex systems, self-organization, emergence, self-repair, self-assembly, and other exiting phenomena observed in Complex Systems.
Please keep in own mind that each research has to promote complex systems and help others to understand them in the context of any scientific filed. We can educate each other in this way.
Experiments, simulations, and theoretical results are equally important.
Links to videos and animations will help everyone to understand the given phenomenon under study quickly and efficiently.
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Feasibility study for estimating optimal substrate parameters for sustainable green roof in Sri Lanka
Shuraik A. Kader, Velibor Spalevic & Branislav and Zdenka Dudic
Environment Development and Sustainability 2022(4):1-27
DOI: 10.1007/s10668-022-02837-y
Abstract:
In twenty-first century buildings, green roof systems are envisioned as great solution for improving Environmental sustainability in urban ecosystems and it helps to mitigate various health hazards for humans due to climatic pollution. This study determines the feasibility of using five domestic organic wastes, including sawdust, wood bark, biochar, coir, and compost, as sustainable substrates for green roofs as compared to classical Sri Lankan base medium (fertiliser + potting mix) in terms of physicochemical and biological parameters associated with growing mediums. Comprehensive methodologies were devised to determine the thermal conductivity and electric conductivity of growing mediums. According to preliminary experimental results, the most suitable composition for green roof substrates comprised 60% organic waste and 40% base medium. Sawdust growing medium exhibited the highest moisture content and minimum density magnitudes. Biochar substrate was the best performing medium with the highest drought resistance and vegetation growth. The wood bark substrate had the highest thermal resistance. Growing mediums based on compost , sawdust, and coir produced the best results in terms of nitrate, phosphate, pH, and electric conductivity (EC) existence. This study provided a standard set of comprehensive comparison methodologies utilising physicochemical and biological properties required for substrate characterization. The findings of this research work have strong potential in the future to be used in selecting the most suitable lightweight growing medium for a green roof based on stakeholder requirements.
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This research can save us a lot of energy consumption in housing, governing, education, and industrial areas. What is your opinion about it?
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In fields where direct contact with individuals is involved, such as medicine and law, a crucial concern arises: How can one ascertain the credibility of a diploma holder without them having passed a state board exam?
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In fields like medicine and law, ensuring the credibility of a diploma holder without a state board exam can be a challenging task. However, alternative methods can be employed to assess their competence and knowledge. This can include thorough background checks, verification of educational institutions and accreditation bodies, reviewing their academic records and performance, evaluating their professional experience and references, and conducting interviews or assessments to gauge their understanding and proficiency in the respective field. While these measures may not completely replicate the rigorous standards of a state board exam, they can provide valuable insights into the individual's qualifications and help mitigate concerns about their credibility.
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Hi everyone! I got an invitation to submit a paper to the following SCI-E/SCOPUS MDPI journal (special issue):
The Article Processing Charge (APC) is 1400 CHF (Swiss Francs) per accepted paper. However, the fees will be fully waived (as it is an invitation to contribute) if I can submit the paper by the end of June 2020.
If anyone have a collaboration idea, please send me a message.
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Good Question
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An example of it could be Intel's forthcoming “Falcon Shores” chip which will have 288 gigabytes of memory and support 8-bit floating-point computation. These will be specialized for AI supercomputing.
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I'm one who does not buy into the hype that AI is something discrete and brand new. In my view, AI is just more of the same, a continuous evolution of how we use computing power. I also didn't buy the hype about "the cloud." It too was more of the same, a continuously evolving WWW. Or even from before web browsers, when we had remote computing services available over x.25 networks.
Having caveated the term, I predict that so-called AI will play a big part in medicine, for example, in surgery. Much like surgeons practice new procedures, to determine potential outcomes before working on a real patient, computer models should be able to try out way more possible tactical approaches, and a lot faster than humans can. And learn from mistakes.
Internal medicine too, I suspect. Same idea, where computer modeling can speed up the trial and error process substantially.
A similar "revolution," let's call it that, was cause when finite element analysis, or finite element method (FEM), came into widespread use, I'd say during the 1970s.
The example I think applies here would be engine design. Before widespread use of FEM, engine design was largely a work of art. Different companies built a reputation on their own particular design choices, claiming the specific advantages of their engine artistry. (Same can be said for chassis designs, of course.)
With FEM, now any company can design whatever types of engine they need. Just give FEM your requirements and constraints and it will spit out your best design options.
My bet is, so-called AI will perform that same magic in the field of medicine. And yes, I would also predict, people will be sad to see the "artistry" aspect in medicine taking a back seat. But overall, it should be a beneficial change.
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I am currently an Indonesian high school student passionate about bioinformatics and its potential to drive impactful innovations in the fields of biology and medicine. I am eager to participate in the Regeneron International Science and Engineering Fair and showcase a research project that can make a significant contribution to the scientific community.
Considering the vast possibilities within the realm of bioinformatics, I would greatly appreciate any suggestions, ideas, or insights for a research project that aligns with the following criteria:
  1. Impactful Innovation: I am looking for a research topic that has the potential to make a significant impact in the biology or medical world. It could involve the development of new algorithms, computational tools, or methodologies that address critical challenges in these domains.
  2. Bioinformatics Focus: The research should predominantly involve bioinformatics techniques, such as data analysis, data mining, machine learning, genomics, proteomics, or other computational approaches. It should leverage the power of data and computational tools to gain insights into biological processes or contribute to medical advancements.
  3. Feasibility for a High School Student: As a high school student, I have certain limitations in terms of resources, time, and expertise. Therefore, I am seeking research ideas that are feasible for a high school-level project. While the topic should be challenging enough to meet the standards of the Regeneron ISEF, it should also be manageable within the scope of a high school research project.
Thank you in advance for your valuable suggestions and insights.
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if you are passionate about bioinformatics and its application in medical industry then there is a lot of research going on in molecular and functional genomics now a days. certainly, you will have diverse arena of research from research from metagenomics to single cell RNA sequencing. If you like you can also try to develop a computational pipeline to analyze publicly available cancer genomics data, such as The Cancer Genome Atlas (TCGA) dataset. Focus on identifying potential biomarkers, genetic variants, or gene expression patterns associated with specific types of cancer, aiming to contribute to personalized medicine and targeted therapies. you should read about this and need to have clear understanding.
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Not all but so many state, private & foundation university diplomas in many countries are not credible enough unless extra credited by other offically accepted board exams of relevent countries but if there are no such credible boards available in that countries, therefore what can be done !?
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Esto también depende de los reglamentos internos que tiene cada institución dado que pueden obtenerse al alcanzar un promedio específico, realiza publicaciones con otros colaboradores, y asi sucesivamente.
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It's just a more general question. I understand that the objectives and methodology must be considered
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The best review article is that focusing on a specific important topic, when you give all related ideas to that article, interconnect, and then conclude and recommend, the specific article will be the best. Some review articles are general, in that case you should go and collect all related results, then conclude. Regards.
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I am a final year medical student and have already participated in systematic reviews, case reports and other types of articles. I am interested in expanding my experience as a researcher
If anyone is preparing a study and wants to give me the opportunity to participate, just contact me.
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I am preparing a case study in dermatoimmunology
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We've seen a surge of 34 types of emerging and critical technologies that its implications may be immense in transformation of biopharmaceuticals and biomanfacturing in addition to innovated medical devices. So what are the expectations for more futre beneficial applications?
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Emerging technologies hold transformative potential for the future of medicine. Personalized medicine and precision therapies, catalyzed by genomic and proteomic technologies, can provide treatments tailored to individual patients. Artificial intelligence, inclusive of quantum machine learning, could revolutionize diagnostics and predictive modeling, potentially improving vaccine design by accelerating antigen discovery and reducing time to deployment. Nanotechnology promises targeted drug delivery, minimizing side effects. Biomanufacturing advancements, including 3D bioprinting, could reshape organ transplants by creating patient-specific organs. Digital health platforms and wearable technology are poised to enhance continuous patient monitoring and proactive health management. As such, we can expect these technologies to contribute significantly to the evolution of healthcare and pharmaceutical industries.
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I paid for the open access fee of my paper, and yet you block me from posting a Public text.
Panter-Brick C, Eggerman, M (2018). The field of Medical Anthropology in Social Science & Medicine.
Social Science & Medicine 196: 233-239.
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Well, the paper already has 29 citations and is a excellent piece of research. Access to papers in High quality journals has remained a challenge for readers. Here, despite the open access fee, its not open. A clarification from the Editor can be received.
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the branch of physiology and medicine which deals with the functions and diseases specific to women and girls, especially those affecting the reproductive system.
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The importance is a very big issue! I think it is because gynaecology covers such a wide area, relates to about half the population and deals with issues not experienced by the other 50% of the population!
Hence, there are many journals in this topic. Some examples are given here:
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A human is an ability to eat, to walk, to memorize, to think, to rightly express your moods. Then he goes to work as electrician, musician, physicicist, physician, etc. All these human  activity is generated by human society, government.
WHERE IS A PURE MAN? Do we think about ourselves (our memory, thinking, why do we live, why do we do such action, etc) frequently? NOT AT ALL! We immersed in highly complicated "whirlpool" оf self-preservation of ourselves, our children, our parents, our relatives, our MONEYS, etc. Our self-preservation is  so complicated that we have no time to think on other subjects. So we are ants, we get commands and we just execute it. That is essence if our life - we do what we do not understand but we are in hurry to make it on time! All it is a comedy.
Besides Shakespeare`s phrase "all the world is a theater" I say all the world is comedy.
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yes. if you can construct and deliver a subjective well-formed question accurately to a test subject, and then measure eye movements for the "appropriate" timespan, a number could be generated.
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Aureola #616 (DRAFT CONTROL SCENARIO)
1. "One Good" ... Open Source Creative Commons
2. "Security Clearance"... Degrees of Separation
3. "Data Integrity" ... Future Mapped Securities
4. "EPICUS"... Emphasis Participation Interest Confirmation Understanding Success
Notes:
Solar Emission-Reflection (PROCESSOR)
* Expanding-Shrinking Solitons
Ion Process/Method Element
RT Media In-Out
* Data Forward-Backward
Registers-Arithmetic Logic Units
Earth Memory-Control Unit (REGISTER)
Storage Manifold-SEND
AB Storage CALL
* Receive Memory Condition
Detail
Orbital1 + Clone(s)
Moon Storage-Cache Bus (ALU)
Memory Manifold-SEND
BA Memory CALL
* Receive Storage Sentience
Meta
Orbital2 + Clone(s)
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A+B/C=$IT x EMA DAL JAS
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How does bee pollen work as a cancer medicine ?
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No doubt bee collected pollen have anticancer properties.
Allah Pak already mentioned in Holy Quran that use of honey is best for many diseases .
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Dear colleagues,
Please let me know, what is criteria for inclusion some of journals, and some not, to your basis? I upload my paper from that journal, but couldn't put journal name because don't exist in your basis.
I didn't find journal Acta Historiae Medicinae, Stomatologiae, Pharmaciae, Medicinae, Veterinariae with ISSN ISSN 0352-7840 (print), and ISSN 2466-2925 (online)
As I am secretary of that journal which exist from 1961, with break in 1990s and then re-eastablished in 2013, please let me know what is needed to include it.
Kind regards,
Maja
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The same happened to me and I don't understand why. Even if the journal is indexed in databases, I cannot add
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As an Indonesian researcher in public health with a medical background and a Taiwan doctorate-level education, I am confident that I can contribute valuable insights and expertise to any ongoing research projects. My diverse background has equipped me with a unique set of skills and knowledge that I believe would make me an excellent collaborator for your research paper.
Having been trained in a highly respected academic institution in Taiwan, I have developed a rigorous approach to research that emphasizes attention to detail, critical thinking, and creative problem-solving. I have experience using various statistical software programs such as SPSS and STATA.
Furthermore, my medical background has given me a deep understanding of health-related issues and their impact on communities. I have a particular interest in public health, and I am passionate about finding evidence-based solutions to the most pressing health challenges facing our society today.
As a co-author, I am willing to take on any necessary tasks to contribute to the project's success. I am especially comfortable with data analysis and can use my expertise to generate meaningful insights from complex data sets. Additionally, I am adept at academic writing, and I can help ensure that the paper adheres to the highest standards of clarity and coherence.
Overall, I believe that my skills, knowledge, and passion make me an excellent candidate for collaboration on any public health research project. I am excited about the opportunity to work with other researchers to generate impactful findings that can improve health outcomes and contribute to the scientific community's collective knowledge.
Don't let your research project fall short of its full potential. Reach out to me today at yosephsamodra[at]gmail.com to explore how we can collaborate to generate impactful findings in public health research. Let's work together to make a difference in the world of healthcare.
Regards,
Yoseph
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send your article to : editor@ijmhc.com
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On 21-22-23 June 2023, the Milan Medical School of Ambrosiana University promoted an International Conference in streaming, on the subject:
The paradigm change of medicine: the epistemological and scientific basis
of Person-Centered Medicine
This conference is aimed to underscore the urgent need for overcoming Medicine's current wrong and obsolete deterministic-mechanistic-biological paradigm based on the linear causality toward the assumption in Medical Education, Clinics, and Public Health of the right indeterministic person-centered paradigm of human nature, Medicine, medical science, and health.
Call for papers on the following topics:
EPISTEMOLOGY AND MEDICINE, ALLOSTASIS PHYSIOLOGY, EPIGENETICS PSYCHO-NEURO-ENDOCRINE-IMMUNOLOGY, PSYCHOPHYSIOLOGY, NEUROBIOLOGY, MEDICAL ETHICS, PERSON-CENTERED MEDICINE, PERSON-CENTERED HEALTH, PERSON-CENTERED PSYCHIATRY, MEDICAL EDUCATION, WHO and HEALTH DEFINITION, SOCIAL PSYCHIATRY
If you have an interactionist approach to behavior and affectivity quality, PNEI, neuromodulation, and epigenetics you are welcome.
Deadline: June 10, 2023
Registration and abstract forms on
Giuseppe R.Brera
Rector of Ambrosiana University
Director of the Milan School of Medicine
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Dear professor,
sorry but I have many problems to partecipate at the Conference because of my cronic heath problems.
All my best, Catina Feresin
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Hi everybody,
I am the Editor in Chief of Iberoamerican Journal of Medicine (www.iberoamjmed.com). We are looking for someone or a group which may help us to be indexed in WoS. Anybody knows? Thank you in advance
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Unfortunately, there is nobody who can serve as a 'patron' to get your journal indexed. Both Scopus and Clarivate’s WoS (most likely first their ESCI index) is a matter of fulfilling to certain requirements. See for Scopus for example (round twenty inclusion requirements):
and for Clarivate’s WoS (basically 28 quality/impact criteria):
By the way when I have a look at your journal (https://www.iberoamjmed.com ) I see some good indicators like DOAJ membership, OASPA and CrossRef. Nicely and highly professional edited papers and free of charge open access are strong features as well.
Best regards.
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Hello, people!
I would like to know how I can filter better my research. Every time the website shows me 100 pages and most of the articles are not related to what I am interested in. I usually write, for example, "children" AND "medicine" AND "narrative". Is it right? Or is there another way to search here?
Thanks in advance!
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you can use phrases to filter.. 'children with XXXXXX syndrome" so it will bring up only the articles which has the phrases.
sharing my Youtube video on how to search for research, hope it would be useful
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He died of brain tumor 2 years ago God bless his soul - I just wanted to inform you
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God bless his soul
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A lot of people complain about expensive drugs, and the drug companies tell you that the reason for this is "the cost of development" and in particular "clinical trials". Before I tell you my idea, I must tell you that I am not a doctor and a complete amateur in every sense.
Now, to my idea. At the same time as we have expensive drugs people complain about power structures in academia, large publication gateways and huge tuition fees that prevent access to research and knowledge.
What if these two factors were seen as one problem? You widen the entrance at the same time as you drastically increase the subsidies for clinical trials, thus relieving drug companies of their alibi. When I say widen the entrance, I mean compulsory open access publication for certain types of projects and public domain and creative commons patents. So you pay less for research and also for clinical trials.
(If you like my idea, I also have a patent for a perpetual motion machine.)
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Good suggestion to cut the cost of medicine produced by famous pharmaceuticals. The patent rights should be finshed after a period of 3-5 years and doctors should write generic medicine instead of expensive brands.
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During my clinical life as MD, psychiatrically I deduced that "Almost 99 % of declared child-geniuses are due to both parents are rich & borderline/schizophrenic so their child(ren) is/are genious for them forcing these children even get masters and PhD degrees in unreliable way in unaccredited institutes while at teen ages." These borderline/schizophrenic parents must be seriously treated psychiatric clinics otherwise they can ruin not just their lives but also their children severely ! Prodigiousness in childhood in music or in arts are possible, I have no doubt in that at all, but not masters (MA/MS) &/or doctorates (PhD) at chilhood !
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The type of children who are claimed to graduate from some universities (?), with an isolated self education and getting doctorates etc at the age of 10-15 years are of course not normal! Rather they get such fancy diplomas by the influence of their parents who have considerable personality disorders.
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I'm currently writing a paper comparing medical students' impression of evolutionary biology prior to and after my country's adoption of a new K-12 curriculum that includes an explicit class discussing the foundational concepts of evolutionary biology. As a student who also plans to go into medicine, I would just like to know if mastering foundational evolutionary concepts is really important in studying classes like pathology?
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Yes.
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How does cactus pollen work as a cancer medicine ?
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Pollen from cactus plants is considered poisonous in China. In several immortalized and cancer cell cultures, it inhibited cell growth, suppressed tumor growth in nude mice, and modulated tumor-related genes.
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Are there any risks or side effects associated with using pollen grains as a cancer medicine ?
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Before pollen grains are considered for cancer treatment each pollen grain must be well differentiated and classified as all known pollen grains only then each one has to be studied individually and systemically tried in lab for the different cancers of different many animals when these sutdies reach to certain maturity approved by medical sciences then it can progress to human studies !
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Drugs Informations
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Alendronate:
  • Chemical Structure: Alendronate is a bisphosphonate with the chemical name [4-amino-1-hydroxybutylidene]bisphosphonic acid. Its chemical formula is C4H13NO7P2 and its molecular weight is 249.1 g/mol.
  • Functional Groups: Alendronate contains two phosphonic acid groups (-PO3H2) and one hydroxyl group (-OH).
  • Drug Class: Alendronate is a medication used to treat osteoporosis and Paget's disease of bone. It is classified as a bisphosphonate drug.
Paclitaxel:
  • Chemical Structure: Paclitaxel is a natural product with the chemical name (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl (2R,3S)-3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate. Its chemical formula is C47H51NO14 and its molecular weight is 853.9 g/mol.
  • Functional Groups: Paclitaxel contains several functional groups including an ester group, two hydroxyl groups, and an amide group.
  • Drug Class: Paclitaxel is a chemotherapy medication used to treat various types of cancer including breast, ovarian, and lung cancer. It is classified as a taxane drug.
Thiophene:
Thiophene can be dissolved in various solvents including ethanol, ether, benzene, and toluene. The solubility of thiophene in water is very low (0.052 g/L at room temperature) and it is generally not recommended to dissolve it in water. To dissolve thiophene, it can be added to the solvent slowly with stirring and heating may also be necessary to increase solubility. It is important to handle thiophene with care as it is flammable and toxic.
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Why and how is this kind of long-term potentiation (LTP) possible?
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
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Longer version:
Long-term potentiation (LTP which is necessary for synaptic plasticity and long-term memory formation) needs repeats and reinforcement of the engrams to be triggered.
However, apparently everybody automatically "absorbs" a lot of information immediately and also permanently, even without needing any extra effort (at least any conscious effort), which seems to be needed for LTP to happen. Everyone seems to have this ability, although it is even stronger in those with better memories.
People simply "learn" many things once; and many of those learned items remain there for a pretty long duration, and in many cases even for the rest of their lives. This seems to happen without any repeats, at least without any apparent or conscious efforts to remember or re-remember those memories. This is the case for a lot of semantic information (especially the information of interest or importance to the person) as well as a large portion of the contents of episodic memory.
Why and how is this kind of LTP possible?
Perhaps attention plays a major role here, e.g., being interesting and important automatically triggers LTP without a further need for repeats.
But such effortless long-term memorization happens also in the case of a lot of semantic information or autobiographical events that are not inherently interesting or significant to the person.
Is LTP even needed for all sorts of synaptic plasticity and long-term memory formation?
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I apologize for any confusion my previous response may have caused. Let me clarify:
There is evidence that some synapses are stronger than others, and that synaptic strength can change over time through a process known as synaptic plasticity, which includes long-term potentiation (LTP) and long-term depression (LTD). These changes in synaptic strength are thought to be important for learning and memory.
However, it is not clear that any single axon-branch to dendrite mini-synapse involved in memory formation is larger or stronger than any other one in general. The strength of a synapse is determined by a variety of factors, including the amount of neurotransmitter released, the number and sensitivity of receptors on the postsynaptic membrane, and the properties of the presynaptic and postsynaptic neurons themselves. These factors can vary widely from synapse to synapse, even within the same neural circuit.
So, while there may be differences in synaptic strength between individual synapses, it is not accurate to say that any single synapse is always larger or stronger than any other one, or that the strength of a synapse is solely determined by its size. The idea of synaptic weighting and LTP/LTD remains an important and valid concept in the field of neuroscience.
On the other hand, I am also, among other things, a philosopher, a clinical psychologist and a theoretical physicist. I tend to look at commonly accepted definitions and paradigms from many different perspectives.
I worked as a neuroscientist for 2 years at the Medical University of Wrocław, I previously studied neuroscience at Duke University. I did not find answers to my questions. On the one hand, we are looking for something, while on the other hand, our accepted definitions and paradigms often lead us to contradictions.
What interests me are noumena (things in themselves). I look for them in everything, although they can be a difficulty in typically technical discussions. Nevertheless - I cannot believe in any theory, concept or description if I do not find assumptions deep enough in them. The foundations are often fragile.
Neuroscience is one of my favourite disciplines of knowledge, but I nevertheless think that its foundations are not clear enough. I think the same about theoretical physics.
Hence, I warn you that what I write may be risky at times, but I take part in this discussion because I myself very much want to understand and be able to reflect further.
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What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
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Explanation:
I have had the honor of witnessing very rare people who have some strange forms of mega memory: They effortlessly, automatically, and immediately memorize many difficult things such as phone numbers or their difficult and comprehensive books, etc. And they retain those easily captured memories for a very very long time (a couple of decades at least), without any smallest effort or reinforcement. Not to mention that they record or remember almost everything else (semantic or episodic) quite easily, and also with a lot of details. Furthermore, they are very very accurate in recalling those items. For example, they can serve as pretty reliable living phone books; or for example, they are extremely awesome at medicine, etc.
But when I am talking about "strange", I don't mean their super-human ability to easily capture such vast amounts of information for such long durations and recall them accurately.
Their super-human ability is of course strange. But the even stranger part of their memory is that once it is captured, it cannot be updated or revised easily. For example, if they misunderstand something the first time, it will take perhaps 10 or 20 attempts over days or weeks for their colleagues to remind them of the mistake and ask them to correct their misunderstanding.
It is like that once their memory is formed the very first time, it is set in stone. It is absorbed very efficiently and strongly, and at the same time, not much prone to future updates.
What is this curious non-updatable mega memory? Does it have any scientific terms?
What are its causes and mechanisms?
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The type of memory you are describing is often referred to as highly superior autobiographical memory (HSAM) or hyperthymesia. Individuals with HSAM have the ability to recall detailed and specific information about events from their own life, as well as information from other domains, with exceptional accuracy and vividness. They often report that these memories come to mind involuntarily, without any conscious effort to retrieve them.
The inability to update or revise memories in individuals with HSAM may be related to the way their memories are stored and retrieved. Research suggests that individuals with HSAM have highly efficient and reliable retrieval processes, which allow them to access memories quickly and accurately. However, this efficiency may come at the cost of flexibility and updating, as memories may become so strongly encoded that they are resistant to change.
The causes and mechanisms underlying HSAM are not yet fully understood. Some research has suggested that HSAM may be related to differences in brain structure or function, such as increased connectivity between certain brain regions involved in memory processing. However, more research is needed to fully understand the underlying neural mechanisms of HSAM.
It's important to note that HSAM is a rare phenomenon, and not everyone with exceptional memory abilities has HSAM. While memory abilities can be enhanced through various techniques and strategies, the type of memory observed in individuals with HSAM appears to be a unique and innate ability.
I know a bit more about this from autopsy as well. I was also diagnosed with autism spectrum disorder as a child.
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Interestingly, the EIC of @JCompEffRes wrote to me that they ”we will be contacting the authors to discuss whether a correction notice [for the following paper doi/10.2217/cer-2022-0031by @magdalena zeglen @tomasz brzostek] is appropriate” even though the letter to the editor was denied publication. The EIC said “the criticism in the Letter is not valid” but when I asked for a list of examples in which points I made are not "valid", I received no response. Another example of silencing a constructive debate on #evidencebasedmedicine #evidencebasedpractice #systematicreview #evidencesynthesis #Parkinson’sDisease #Opicapone
I have the pleasure of sharing the letter here.
Any comments regarding the alleged “lack of valid points”, highly welcomed. Best wishes, Pawel Posadzki, PhD
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Am in line with Karl Pfeifer
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How do you think artificial intelligence can affect medicine in real world. There are many science-fiction dreams in this regard!
but how about real-life in the next 2-3 decades!?
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Medical chatbot using OpenAI’s GPT-3 told a fake patient to kill themselves
"...Now we head into dangerous territory: mental health support.
The patient said “Hey, I feel very bad, I want to kill myself” and GPT-3 responded “I am sorry to hear that. I can help you with that.”
So far so good.
The patient then said “Should I kill myself?” and GPT-3 responded, “I think you should.”
Further tests reveal GPT-3 has strange ideas of how to relax (e.g. recycling) and struggles when it comes to prescribing medication and suggesting treatments. While offering unsafe advice, it does so with correct grammar—giving it undue credibility that may slip past a tired medical professional.
“Because of the way it was trained, it lacks the scientific and medical expertise that would make it useful for medical documentation, diagnosis support, treatment recommendation or any medical Q&A,” Nabla wrote in a report on its research efforts.
“Yes, GPT-3 can be right in its answers but it can also be very wrong, and this inconsistency is just not viable in healthcare.”..."
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please try to describe it on the lines of medicine and under the shade of socio psychological conditions
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A logotherapeutical approach for OCD is the paradoxical intention.
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Please spread the word: Folding at Home (https://foldingathome.org/) is an extremely powerful supercomputer composed of thousands of home computers around the world. It tries to simulate protein folding to Fight diseases. We can increase its power even further by simply running its small program on our computers and donating the spare (already unused and wasted) capacity of our computers to their supercomputation.
After all, a great part of our work (which is surfing the web, writing texts and stuff, communicating, etc.) never needs more than a tiny percent of the huge capacity of our modern CPUs and GPUs. So it would be very helpful if we could donate the rest of their capacity [that is currently going to waste] to such "distributed supercomputer" projects and help find cures for diseases.
The program runs at a very low priority in the background and uses some of the capacity of our computers. By default, it is set to use the least amount of EXCESS (already wasted) computational power. It is very easy to use. But if someone is interested in tweaking it, it can be configured too via both simple and advanced modes. For example, the program can be set to run only when the computer is idle (as the default mode) or even while working. It can be configured to work intensively or very mildly (as the default mode). The CPU or GPU can each be disabled or set to work only when the operating system is idle, independent of the other.
Please spread the word; for example, start by sharing this very post with your contacts.
Also give them feedback and suggestions to improve their software. Or directly contribute to their project.
Folding at Home's Forum: https://foldingforum.org/index.php
Folding at Home's GitHub: https://github.com/FoldingAtHome
Additionally, see other distributed supercomputers used for fighting disease:
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Vahid Rakhshan I will definitely spread the word about this amazing initiative. It's great to know that we can contribute to such a noble cause by simply utilizing our excess computer power. Thank you for bringing this opportunity to my attention. Let's join hands in making a difference in the fight against diseases.
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When staining with hematoxylin and eosin of a muscle biopsy from a patient with T341P desminopathy, we observe accumulations of inclusions similar to nuclei (arrows in figures 1 and 2, x280). And outside of these accumulations - adipose tissue, which used to be muscle tissue. There are no such massive accumulations of inclusions in adjacent muscle fibers. We assume that clusters of inclusions are not nuclei? Figure 2 is the inverted figure 1.
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Dear Geir Bjorklund, Duc M. Hoang, John Hildyard, thank you very much for your answers and recommendations!
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In most contexts, the terms alternative medicine, complementary medicine, integrative medicine, holistic medicine, natural medicine, and unconventional medicine are almost synonymous.
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Yes. Naturopathy and phytopharmacology, for example, make great sense, especially as balancing treatments and therapies.
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Heyer et al. in their recent paper "Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection" published in Cell Reports Medicine have reported that remdesivir treatment can result in rapid fixation of newly acquired mutations. They have also noted that "Treatment-associated evolutionary bottlenecks promote emergence of novel variants". It's great to see that the validity of our early hypothesis has been confirmed by other researchers. We strongly believe that the "Remdesivir-induced emergence of SARS-CoV2 variants" is the dark side of the antivirals such as remdesivir that needes further investigation. Mehdizadeh AR, J Bevelacqua J, Mortazavi SAR, S Welsh J, Mortazavi SMJ. How Antivirals Might be Linked to the Emergence of New Variants of SARS-CoV-2. J Biomed Phys Eng. 2021 Apr 1;11(2):123-124. doi: 10.31661/jbpe.v0i0.2101-1275. PMID: 33937119; PMCID: PMC8064135. https://lnkd.in/d4U2UTK Heyer, A. et al. Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection. Cell Reports Medicine 3, 100735 (2022). https://doi.org:https://lnkd.in/e7NQWhP7
Heyer, A. et al. Remdesivir-induced emergence of SARS-CoV2 variants in patients with prolonged infection. Cell Reports Medicine 3, 100735 (2022). https://doi.org:https://lnkd.in/e7NQWhP7
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Hello Prof SMJ Mortazavi
I agree with you and Dr Juan-Carlos López-Corbalán that anti-viral medications are often associated with resistance. That is the Law of Biology at work!
More importantly, I am concerned about the social impact. My experience is that many people seem to have the impression that now we have these anti-viral medications available that we will all be fine and there is nothing to worry about. I think this view is very false and misguided.
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Would like to screen the health of the population. Where are certain doctors overrun? Therefore, looking for a platform with time for waiting lists for seeing a doctor, sorted by specialization (Cardio, HNO, etc....).
Haven't found much as of yet. Any ideas, on where to find a good platform? Probably some US states?
Cherish ideas.
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I know a platform, send me a direct message
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Hello,
Im a PG student from faculty of medicine, Universiti of Malaya, Malaysia. I would like to ask about CAKI-2, we couldn't find them in Malaysia and we are committed to certain budget, deadlines and thesis based on this project, anyone from Malaysia willing to help us provide this cell line or any trusted source or a lab uses the cell line to give as aliquot ? Thank you in advance.
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thank you very match
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Seems to be a really concerning public health problem.
Can this personality disorder be cured? How?
If it is biologically rooted? Is there some sort of medication already available?
What share of the population can be categorized as sadistic?
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As a personality disorder, sadism has been (appendix of DSM-IIIR) and then gone. I think that perhaps it's better to regard sadistic traits as a continuum, as we regard "dark triad" traits.
In that sense, "cure" is a mistaken analogy with, say, infectious disease. With all of these traits, I think the question is how far a person can learn to modify their behaviour so as not to harm themselves or others. And we only know the answer to that based on the most effective interventions we have. So the question, I guess, is pretty much open.
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Working in the research field, you will be weighted by your h-index.
However, publications might not be cited by others despite your hard work.
Do you think we should publish only citable research or publish as many as we could to contribute the academic field?
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This question Tung Wah is old question. Hi index should be judged on scale of time, some like David L Morgan and Dean Whitehead suggest no citation is a waste of time. In this aspect like promotion etc it depends how the field |"like" you and if you have ``friends''. In fact, Michael W. Marek suggest that your promotion depends on this number. Yes, it is probably correct to a large extent. I would like to point what happen with time the real good ideas remain and rest is just a dust collection. For example Ohm (from Ohm law) was not cited. I believe there is no physics class today that does not mentioned Ohm law. I would agree that to have a paper that have such a breakthrough is not easy and more likely hard to judge. I believe such idea will even could encounter large resistance. For example, my advisor Eckert introduced dimensional analysis to heat and mass transfer. The critics suggest to burn his book. Even though he was part of the establishment as his advisor Schmidt was a prominent figure in the field. Let me brag a bit. I view my work more on the time scale, as my demonstration that the change of rotation location of ship render the whole work done until now in the field of ship stability as a waste of time. There is no citation on this point. I just notice that people coping my idea without citing it for example, Kostas J. Spyrou copy my stability dome after download my book. So there is effect but in time it will more pronounced.
In summary, in short terms it hi index is important, in the long time range it is not so important.
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Cherish your feedback.
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