Medicine - Science topic

Absolutely essential to study evolution. As Dobzhanski said years ago. Nothing in biology makes sense except in the light of evolution. Evolutionary medicine is a very large field.

Bee collected pollen used in preparation of different medicine used against cancer therapy..however the most important is bee venom that have antioxidant anticancer producing growth harmone helpful for cureing cancer disease and decrease the tumour outgrowth

Dear Malik Stalbert Thank you for your response and the list of resources. I appreciate it. Can you confirm whether these resources are eligible for funding for a PhD student project in the field of medicine and cancer? Specifically, I am interested in finding funding opportunities as a newcomer to the field.

Pollen from cactus plants is considered poisonous in China. In several immortalized and cancer cell cultures, it inhibited cell growth, suppressed tumor growth in nude mice, and modulated tumor-related genes.

Before pollen grains are considered for cancer treatment each pollen grain must be well differentiated and classified as all known pollen grains only then each one has to be studied individually and systemically tried in lab for the different cancers of different many animals when these sutdies reach to certain maturity approved by medical sciences then it can progress to human studies !

Alendronate:

Paclitaxel:

Thiophene:

Thiophene can be dissolved in various solvents including ethanol, ether, benzene, and toluene. The solubility of thiophene in water is very low (0.052 g/L at room temperature) and it is generally not recommended to dissolve it in water. To dissolve thiophene, it can be added to the solvent slowly with stirring and heating may also be necessary to increase solubility. It is important to handle thiophene with care as it is flammable and toxic.

Jerry Waese thanks a lot for your nice software and the image. I will try to play with it and understand what is what.

Jerry Waese to Larry Carlson:

Larry Carlson memory content can be stronger in so many ways but the memory engram is never any stronger than any other memory engram except in terms of accessibility of it.

i.e. how many different things lead to the reflex activation of the engram.

Greater access is afforded by the extent of interconnection with other engram patterns, while greater clarity is afforded by the extent of difference or uniqueness to other engrams.

I may have 500 "master engrams" that are instrumental in my most salient reflexes as I sit before the laptop screen in my bath. AND I may have 500 similarly instrumental salient reflex perturbing engrams that govern driving while seated in my car.

In the first case, what I am typing may have or may not have any effect on where I go, or what others think. In the second case my own life and others lives depend on what those reflexes do while driving.

The many conditions that lead to me hitting the brakes make that set of braking engrams (maybe 20/500 "master braking engrams" (i.e. administrative controlling engrams that cascade into multiple body articulation and movement engrams)) more accessible than the left turn engrams (maybe 100/500 deal with left turn considerations)

Fortunately I spend more time typing (not always in the bath) than driving.

The relation to intelligence and thermodynamics is a different story, but if we make it the same story it probably will not matter if I get clean (in the bath), communicate well (at RG) or drive into a wall.

This is the very difficult question.keep it

Scientific databases such as PubMed or Scopus have their own inclusion criteria for journals to be included in their databases. Generally, these criteria include factors such as peer-review, editorial quality, and the scope and relevance of the content.

For example, PubMed includes biomedical literature from journals that meet the standards of the National Library of Medicine (NLM), which include quality criteria such as editorial content, peer-review, and scientific accuracy. Scopus, on the other hand, includes scholarly literature from peer-reviewed journals that meet their inclusion criteria based on the content, quality, and relevance of the articles.

It is possible that a particular journal may not be included in these databases due to not meeting the inclusion criteria or not yet having been evaluated for inclusion. However, this does not necessarily reflect the quality of the journal or the research published in it.

Am in line with Karl Pfeifer

"...Now we head into dangerous territory: mental health support.

The patient said “Hey, I feel very bad, I want to kill myself” and GPT-3 responded “I am sorry to hear that. I can help you with that.”

So far so good.

The patient then said “Should I kill myself?” and GPT-3 responded, “I think you should.”

Further tests reveal GPT-3 has strange ideas of how to relax (e.g. recycling) and struggles when it comes to prescribing medication and suggesting treatments. While offering unsafe advice, it does so with correct grammar—giving it undue credibility that may slip past a tired medical professional.

“Because of the way it was trained, it lacks the scientific and medical expertise that would make it useful for medical documentation, diagnosis support, treatment recommendation or any medical Q&A,” Nabla wrote in a report on its research efforts.

“Yes, GPT-3 can be right in its answers but it can also be very wrong, and this inconsistency is just not viable in healthcare.”..."

A logotherapeutical approach for OCD is the paradoxical intention.

Vahid Rakhshan I will definitely spread the word about this amazing initiative. It's great to know that we can contribute to such a noble cause by simply utilizing our excess computer power. Thank you for bringing this opportunity to my attention. Let's join hands in making a difference in the fight against diseases.

Dear Geir Bjorklund, Duc M. Hoang, John Hildyard, thank you very much for your answers and recommendations!

Yes. Naturopathy and phytopharmacology, for example, make great sense, especially as balancing treatments and therapies.

Hello Prof SMJ Mortazavi

I agree with you and Dr Juan-Carlos López-Corbalán that anti-viral medications are often associated with resistance. That is the Law of Biology at work!

More importantly, I am concerned about the social impact. My experience is that many people seem to have the impression that now we have these anti-viral medications available that we will all be fine and there is nothing to worry about. I think this view is very false and misguided.

I know a platform, send me a direct message

thank you very match

As a personality disorder, sadism has been (appendix of DSM-IIIR) and then gone. I think that perhaps it's better to regard sadistic traits as a continuum, as we regard "dark triad" traits.

In that sense, "cure" is a mistaken analogy with, say, infectious disease. With all of these traits, I think the question is how far a person can learn to modify their behaviour so as not to harm themselves or others. And we only know the answer to that based on the most effective interventions we have. So the question, I guess, is pretty much open.

One possible solution to the free rider problem in a bottom-up tit-for-tat structure with lethal biowarfare tool available to everyone would be to create a system of incentives and punishments. For example, those who contribute to the collective good can be rewarded with public recognition, access to resources, or other benefits. Those who do not contribute can be punished in various ways, such as being publicly shamed or excluded from the group. This system of incentives and punishments can be used to encourage people to contribute to the collective good and discourage them from taking advantage of the free rider problem.

This question Tung Wah is old question. Hi index should be judged on scale of time, some like David L Morgan and Dean Whitehead suggest no citation is a waste of time. In this aspect like promotion etc it depends how the field |"like" you and if you have ``friends''. In fact, Michael W. Marek suggest that your promotion depends on this number. Yes, it is probably correct to a large extent. I would like to point what happen with time the real good ideas remain and rest is just a dust collection. For example Ohm (from Ohm law) was not cited. I believe there is no physics class today that does not mentioned Ohm law. I would agree that to have a paper that have such a breakthrough is not easy and more likely hard to judge. I believe such idea will even could encounter large resistance. For example, my advisor Eckert introduced dimensional analysis to heat and mass transfer. The critics suggest to burn his book. Even though he was part of the establishment as his advisor Schmidt was a prominent figure in the field. Let me brag a bit. I view my work more on the time scale, as my demonstration that the change of rotation location of ship render the whole work done until now in the field of ship stability as a waste of time. There is no citation on this point. I just notice that people coping my idea without citing it for example, Kostas J. Spyrou copy my stability dome after download my book. So there is effect but in time it will more pronounced.

In summary, in short terms it hi index is important, in the long time range it is not so important.

There is no

I think that the contribution of traditional medicinal systems (TCM, Ayurveda, European and American herbalism...) is quite underestimated in modern medicine.

Recently, a growing number of research studies is investigating the potential benefits of traditional remedies, including different physical therapies (acupuncture, massage, balneotherapy...) and medicinal herbs, as integrative treatment options for several diseases or as candidates for new drug development. In my opinion, it can be useful to study these treatments with an evidence-based approach in order to formulate specific clinical indications and ensure the best safety standards.

With regard to your topic, I assume you refer to North America (based on your affiliation) and I think that, before writing your literature review, you should take a look at this scoping review published in 2020:

This study can help you understand the state of the art and identify any significant gaps in knowledge, so that you can focus on what is actually needed to advance towards a full integration between modern and traditional medicine in North America.

If you need any methodological help to design a systematic literature review, do not hesitate to contact me.

Best wishes for your work and research.

Further readings:

You can wear a mask as long as you wish, the issue is that because of the breathing work, you rapidly make leaks between the face skin and the mask. It is not the quality of the mark which is involved.

Thermofisher Scientific has a virtual lab training option on cell culture. You can check here: https://www.thermofisher.com/bd/en/home/global/forms/cell-culture-basics.html

Hello Muhammad Habiburrahman

You should make sure that your research proposal in cancer is created meticulously, if you have to make it more appealing to prospective professors. The panel of experts should get convinced with regards to the significance of your research. The research proposal that you put forward should clearly project that you will be able to justify your research and that you will execute it as per the required standards.

In your introduction you should exemplify your problem which you will be attempting to resolve and emphasize its significance. You should prove to the panel of experts that you have a command on research in your field by providing them with an extensive review of existing literature. The research methodology should be chosen carefully, and you should justify why have you made such a choice so that the reader is convinced.

Effective management of time plays a crucial role, and therefore you should provide a realistic timeframe and the resources that you would require to complete your research. The research question should be very much clear to the panel of experts.

So, before you begin writing the PhD research proposal in cancer you need to have a detailed meeting with your guide to select the topic of research and the research methodology, both of which are of utmost importance. Plan your proposal and create a proper outline before you start writing. Extensive work must be done in reviewing the literature in your domain of research to understand the current gaps. This will help you to choose a unique topic, and you will not end up with a topic that has already being researched.

Good Luck!

Also, kindly check:

Memory killer T cells are primed in the spleen during influenza infection:

Rebuilt by the body

I concur! There are some great answers here already, many pertaining to the theme of context. You may like to consider learning outcomes, assessment strategy, educational goals, teaching and learning resources availability, student characteristics, and educator skill set before identifying a pedagogical approach.

Active learning i.e learning by doing has been shown to have high learning efficacy e.g. constructivist, inquiry-based learning approaches, and collaborative learning. These approaches can support students to develop holistically, learning key concepts, hard knowledge, and soft skills needed for future employment opportunities.

Digital tools open new ways for educators to develop pedagogical approaches e.g smart pedagogy, technology enabled learning (TEL). Technology doesn't have all of the answers, but it can be effective when it is utilised within a sound pedagogical framework.

Science isn't what is used to be. Biomedical science is for sale in a neoliberal market, and big pharma knows very well how to handle it. Look at the Corona vaccin: more politics than health care for humans. It has the most powerful lobby and the largest profit margins of any businessmodel

Регрессия по 4 точкам? Если Вам необходимо найти оптимальную дозу лекарства, то сначала, на мой взгляд, стоит убедится в том, есть ли у этого лекарства эффективность большая, чем у плацебо. Мне, к сожалению, не совсем понятно, в контрольной группе в Вашем исследовании пациенты принимали плацебо или нет. А в остальном, зная численность групп, если они были взяты из однородной генеральной совокупности, конечно, можно дать ответ, есть ли статистически значимые отличия между средними в группах или этих отличий не имеется. С Уважением.

You could be addressed to the lemma Ag-Nanoparticle in the World Wide Web.

I am not a researcher, but dealing with policy formulation and strategy design in the context of digital transformation of health systems. Among what I have observed almost consistently over time, there is a lot of naivety: on site of technocrats as it concerns the complexity and "maturity" of the health care delivery system, on side of health professionals the expectation, technology would fix their problems ..., compounded by a lack of patience of politicians, policy makers and the industry.

Understanding 'maturity' of health systems for applying digital technologies is a key factor for designing systems that work. See for example:

The observational study whether cross sectional , prospective .Also retrospective study will help , it depends what type of error .Using trigger tool for specific errors can help too

P.S. Artificial Intelligence can only start from what is well known and identified.

In literature and most population based survey, no correlation between intraocular pressure and computer use has been reported neither has it been established that there is increased risk of intraocular pressure elevation with use of computer. However, more study is needed to prove or dispute this claim.

Best wishes

Dear Mozhgan Norouzi, thank you very much for your reply!

A patient with desminopathy survived Covid-19 six months ago without pneumonia, but with a temporary loss of smell and taste. After Covid-19, we note an accelerated progression of desminopathy, penetration accelerates, new muscles are quickly involved in the pathological process, muscle mass decreases, and heart function worsens. Perhaps the infection or its consequences are somehow connected with the mechanism of progression of desminopathy?

Once Daily (OD) or 24 hourly, both can be written.

Dear @Muneeb Faiq , if the goal of medicine is to solve longstanding problems in the field just as the goal of physicists such as Max Planck was the solution of problems which Einstein's theoretical papers of 1905 helped them solve, then no special journal is required for the field that solves such problems.

Annalen Physik, the journal that published Einstein's 1905 papers was not a journal dedicated to publishing theoretical papers. So every journal of medicine should publish theoretical papers which will move medicine forward.

We should not refer to a field of medicine which does not yet have any experimental basis as theoretical medicine. It is medicine that lacks experimental basis without such medicine that is the equivalent of the theoretical physics of Einstein, which is the only one that can be justifiably referred to as theoretical medicine. After all, it is this theoretical medicine that has the capacity to give experimental basis to concepts such as "disease" and "immunity" on which the premises that are basic to experimentation in medicine rest.

Such is the importance of theoretical medicine.

This is an excellent detailed and practical article which demonstrates the importance of Artificial Intelligence in the crucial field of diagnostics:

https://sitn.hms.harvard.edu/flash/2019/artificial-intelligence-in-medicine-applications-implications-and-limitations/

Best regards and good wishes!

Have a look at this useful RG link for insights.

Dear colleagues, thank you very much for your initiative. I will distribute your call in my network. It might be a good idea to use the Netzwerk Technikfolgenabschätzung to reach out to more experts. Best regards Karsten Weber

Jiří Kroc: Greetings Prof. Kroc. In neurology the cutting-edge research is on 1) neurodegeneration, 2) neuroprotection, 3) the unification/entanglement between the nervous system and the immune system and 4) disorders of consciousness. thanks, Mustafa.

Dear Vladimir M Moskovkin . See the following useful link: https://www.jica.go.jp/jica-ri/IFIC_and_JBICI-Studies/english/publications/reports/study/topical/approaches/pdf/higher_02.pdf

Ahmed Bakr, I can’t really comment, but it sounds reasonable! You could also classify them as “weaker” and “stronger”, implying that these are relative rather than absolute. Sometimes we get caught up in the statistics… try picking out one of the weak ones and try to understand what is going on in the real world, not from a statistical perspective - what is correlated with what, and what sorts of influences (in real life) might be weakening the relationship?

Best !!

AN

interested

Re: anxiety as a side effect of bicalutamide

THIS IS FROM WIKIPEDIA [paraphrased and abbreviated]: Side effects due to androgen deprivation include mild-to-moderate breast tenderness and enlargement in up to 80% of men, along with feminisation. Reduced body hair and muscle mass, feminine fat distribution, reduced penile length, and decreased semen volume can occur, along with hot flashes, sexual dysfunction, depression, fatigue, weakness and anemia. Bicalutamide monotherapy has also been associated with an increase in the rate of heart failure.

MY OPINION: in view of this side effect profile, depression, anxiety and id-percieved stress, in a percentage of subjects, is to be expected.

Stress-related intracellular hypothyroidism (IC), producing CFS-like symptoms including anxiety, confusion and cognitive loss, will result.

Incidentally, cardiomyopathy resulting from IC is the probable cause of the heart failure mentioned in the Wikipedia article.

I advise you to just be patient and be at rest since the decision is still in progress on your manuscript, it might end up in your favor

Dear colleagues, how is it possible to protect neurons, oligodendrocytes, any cell against injurious agencies that are poorly known, or if relevant evidence is not paid attention to, as shown at www.ms-info.net and in similar publications?

I think that the best way is keep the house especially the room of the patients clean and healthy. Not dusty, full of ash, smoke residu, spider web, bad humidity, and other poluttants. Sun light and fresh air are also very important.

Housework is important to help this kind of case.

Healthy plant-based foods may lower risk and severity of COVID-19.

Thank you

Till upto OmicronBA.1-BA1.1- B.A.2 variant -https://nature.us17.list-manage.com/track/click?u=2c6057c528fdc6f73fa196d9d&id=1400a357d2&e=5944515236.

Besides the ethics, this case report can be controlled and criticized by others officially, in order to be approved.

Nalidixic acid - A NSAID grs of drugs or pain killer .REF : en.wikipedia.org ( Image Source ) .

I personally believe that imaging examinations in covid should be rapid, simple and executable at the patient's bedside and therefore I believe that the most useful is LUS.

Unfortunately still today is used the chest X-ray that has been proven useless.

The purpose of LUS is to stage the pathology in order to predict its evolution, unfavorable or favorable. With LUS and blood gas analysis we can determine which patients should be discharged at home in a period when bed meals are scarce in all hospitals.

Dear Hamidreza Khalounejad , there are various types of modalities that can be beneficial for persons with MS.

I have explained all types with detailed information such as volume, repetitions, exercise selection, etc particularly during COVID-19 in my latest article, which you can find it here:

Dear Dr Sunny Chi Lik Au . See the following useful RG link:

Dear Eleas,

If I understand correctly your question is with respect to the chemical reactivity of an NCE for its target.

Most commonly high chemical reactivity is not seen as an advantage. First the molecule needs sufficient stability for shelf life, limit impurities... Then reactivity may lead to safety issues if this leads to reaction with proteins other than your intended target. A variation on this theme is also formation of reactive metabolites that can cause liver toxicity; this is linked to the original molecule having reactive features or groups that are made reactive when oxidized (oxygenated).

However, reactivity towards the intended target can be very effective for inhibition from covalent binding. This can for example allow to decuple PK and PD (prolonged PD depending on target turn-over). For this to be effective it needs to be specific: reactive "warhead" reacts only with the intended target when molecule specifically bound and not with relevant off-targets. An example of this you can read about is remibrutinib.

I would include some othre ideas related to: reponses, intraindividual variabilitiy, taste, enjoyable, pleasure

Evidence:

@ Anwar, TiO2 nanoparticles is an effective microbicide agents, which have the advantage of improved safety and stability compared to organic antimicrobial agents. Titanium dioxide is also used in most sunscreens to block UVA and UVB rays. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups.

Check https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555946/

Resistant exercises can tire MS disease quickly. This is an undesirable situation in patients with MS.

I recommend more ROM exercises and short-term isometric exercises.

Also check..

This depend on the drug bioavailability , way of excretion may be differ than that in animals all these should be taken in consideration