Medicine - Science topic

Hello Prof SMJ Mortazavi

I agree with you and Dr Juan-Carlos López-Corbalán that anti-viral medications are often associated with resistance. That is the Law of Biology at work!

More importantly, I am concerned about the social impact. My experience is that many people seem to have the impression that now we have these anti-viral medications available that we will all be fine and there is nothing to worry about. I think this view is very false and misguided.

I know a platform, send me a direct message

thank you very match

As a personality disorder, sadism has been (appendix of DSM-IIIR) and then gone. I think that perhaps it's better to regard sadistic traits as a continuum, as we regard "dark triad" traits.

In that sense, "cure" is a mistaken analogy with, say, infectious disease. With all of these traits, I think the question is how far a person can learn to modify their behaviour so as not to harm themselves or others. And we only know the answer to that based on the most effective interventions we have. So the question, I guess, is pretty much open.

One possible solution to the free rider problem in a bottom-up tit-for-tat structure with lethal biowarfare tool available to everyone would be to create a system of incentives and punishments. For example, those who contribute to the collective good can be rewarded with public recognition, access to resources, or other benefits. Those who do not contribute can be punished in various ways, such as being publicly shamed or excluded from the group. This system of incentives and punishments can be used to encourage people to contribute to the collective good and discourage them from taking advantage of the free rider problem.

This question Tung Wah is old question. Hi index should be judged on scale of time, some like David L Morgan and Dean Whitehead suggest no citation is a waste of time. In this aspect like promotion etc it depends how the field |"like" you and if you have ``friends''. In fact, Michael W. Marek suggest that your promotion depends on this number. Yes, it is probably correct to a large extent. I would like to point what happen with time the real good ideas remain and rest is just a dust collection. For example Ohm (from Ohm law) was not cited. I believe there is no physics class today that does not mentioned Ohm law. I would agree that to have a paper that have such a breakthrough is not easy and more likely hard to judge. I believe such idea will even could encounter large resistance. For example, my advisor Eckert introduced dimensional analysis to heat and mass transfer. The critics suggest to burn his book. Even though he was part of the establishment as his advisor Schmidt was a prominent figure in the field. Let me brag a bit. I view my work more on the time scale, as my demonstration that the change of rotation location of ship render the whole work done until now in the field of ship stability as a waste of time. There is no citation on this point. I just notice that people coping my idea without citing it for example, Kostas J. Spyrou copy my stability dome after download my book. So there is effect but in time it will more pronounced.

In summary, in short terms it hi index is important, in the long time range it is not so important.

There is no

I think that the contribution of traditional medicinal systems (TCM, Ayurveda, European and American herbalism...) is quite underestimated in modern medicine.

Recently, a growing number of research studies is investigating the potential benefits of traditional remedies, including different physical therapies (acupuncture, massage, balneotherapy...) and medicinal herbs, as integrative treatment options for several diseases or as candidates for new drug development. In my opinion, it can be useful to study these treatments with an evidence-based approach in order to formulate specific clinical indications and ensure the best safety standards.

With regard to your topic, I assume you refer to North America (based on your affiliation) and I think that, before writing your literature review, you should take a look at this scoping review published in 2020:

This study can help you understand the state of the art and identify any significant gaps in knowledge, so that you can focus on what is actually needed to advance towards a full integration between modern and traditional medicine in North America.

If you need any methodological help to design a systematic literature review, do not hesitate to contact me.

Best wishes for your work and research.

Further readings:

You can wear a mask as long as you wish, the issue is that because of the breathing work, you rapidly make leaks between the face skin and the mask. It is not the quality of the mark which is involved.

Thermofisher Scientific has a virtual lab training option on cell culture. You can check here: https://www.thermofisher.com/bd/en/home/global/forms/cell-culture-basics.html

Hello Muhammad Habiburrahman

You should make sure that your research proposal in cancer is created meticulously, if you have to make it more appealing to prospective professors. The panel of experts should get convinced with regards to the significance of your research. The research proposal that you put forward should clearly project that you will be able to justify your research and that you will execute it as per the required standards.

In your introduction you should exemplify your problem which you will be attempting to resolve and emphasize its significance. You should prove to the panel of experts that you have a command on research in your field by providing them with an extensive review of existing literature. The research methodology should be chosen carefully, and you should justify why have you made such a choice so that the reader is convinced.

Effective management of time plays a crucial role, and therefore you should provide a realistic timeframe and the resources that you would require to complete your research. The research question should be very much clear to the panel of experts.

So, before you begin writing the PhD research proposal in cancer you need to have a detailed meeting with your guide to select the topic of research and the research methodology, both of which are of utmost importance. Plan your proposal and create a proper outline before you start writing. Extensive work must be done in reviewing the literature in your domain of research to understand the current gaps. This will help you to choose a unique topic, and you will not end up with a topic that has already being researched.

Good Luck!

Also, kindly check:

Memory killer T cells are primed in the spleen during influenza infection:

Rebuilt by the body

I concur! There are some great answers here already, many pertaining to the theme of context. You may like to consider learning outcomes, assessment strategy, educational goals, teaching and learning resources availability, student characteristics, and educator skill set before identifying a pedagogical approach.

Active learning i.e learning by doing has been shown to have high learning efficacy e.g. constructivist, inquiry-based learning approaches, and collaborative learning. These approaches can support students to develop holistically, learning key concepts, hard knowledge, and soft skills needed for future employment opportunities.

Digital tools open new ways for educators to develop pedagogical approaches e.g smart pedagogy, technology enabled learning (TEL). Technology doesn't have all of the answers, but it can be effective when it is utilised within a sound pedagogical framework.

Science isn't what is used to be. Biomedical science is for sale in a neoliberal market, and big pharma knows very well how to handle it. Look at the Corona vaccin: more politics than health care for humans. It has the most powerful lobby and the largest profit margins of any businessmodel

Регрессия по 4 точкам? Если Вам необходимо найти оптимальную дозу лекарства, то сначала, на мой взгляд, стоит убедится в том, есть ли у этого лекарства эффективность большая, чем у плацебо. Мне, к сожалению, не совсем понятно, в контрольной группе в Вашем исследовании пациенты принимали плацебо или нет. А в остальном, зная численность групп, если они были взяты из однородной генеральной совокупности, конечно, можно дать ответ, есть ли статистически значимые отличия между средними в группах или этих отличий не имеется. С Уважением.

You could be addressed to the lemma Ag-Nanoparticle in the World Wide Web.

I am not a researcher, but dealing with policy formulation and strategy design in the context of digital transformation of health systems. Among what I have observed almost consistently over time, there is a lot of naivety: on site of technocrats as it concerns the complexity and "maturity" of the health care delivery system, on side of health professionals the expectation, technology would fix their problems ..., compounded by a lack of patience of politicians, policy makers and the industry.

Understanding 'maturity' of health systems for applying digital technologies is a key factor for designing systems that work. See for example:

The observational study whether cross sectional , prospective .Also retrospective study will help , it depends what type of error .Using trigger tool for specific errors can help too

P.S. Artificial Intelligence can only start from what is well known and identified.

In literature and most population based survey, no correlation between intraocular pressure and computer use has been reported neither has it been established that there is increased risk of intraocular pressure elevation with use of computer. However, more study is needed to prove or dispute this claim.

Best wishes

Dear Mozhgan Norouzi, thank you very much for your reply!

A patient with desminopathy survived Covid-19 six months ago without pneumonia, but with a temporary loss of smell and taste. After Covid-19, we note an accelerated progression of desminopathy, penetration accelerates, new muscles are quickly involved in the pathological process, muscle mass decreases, and heart function worsens. Perhaps the infection or its consequences are somehow connected with the mechanism of progression of desminopathy?

Once Daily (OD) or 24 hourly, both can be written.

Dear @Muneeb Faiq , if the goal of medicine is to solve longstanding problems in the field just as the goal of physicists such as Max Planck was the solution of problems which Einstein's theoretical papers of 1905 helped them solve, then no special journal is required for the field that solves such problems.

Annalen Physik, the journal that published Einstein's 1905 papers was not a journal dedicated to publishing theoretical papers. So every journal of medicine should publish theoretical papers which will move medicine forward.

We should not refer to a field of medicine which does not yet have any experimental basis as theoretical medicine. It is medicine that lacks experimental basis without such medicine that is the equivalent of the theoretical physics of Einstein, which is the only one that can be justifiably referred to as theoretical medicine. After all, it is this theoretical medicine that has the capacity to give experimental basis to concepts such as "disease" and "immunity" on which the premises that are basic to experimentation in medicine rest.

Such is the importance of theoretical medicine.

This is an excellent detailed and practical article which demonstrates the importance of Artificial Intelligence in the crucial field of diagnostics:

https://sitn.hms.harvard.edu/flash/2019/artificial-intelligence-in-medicine-applications-implications-and-limitations/

Best regards and good wishes!

Have a look at this useful RG link for insights.

Dear colleagues, thank you very much for your initiative. I will distribute your call in my network. It might be a good idea to use the Netzwerk Technikfolgenabschätzung to reach out to more experts. Best regards Karsten Weber

Jiří Kroc: Greetings Prof. Kroc. In neurology the cutting-edge research is on 1) neurodegeneration, 2) neuroprotection, 3) the unification/entanglement between the nervous system and the immune system and 4) disorders of consciousness. thanks, Mustafa.

Dear Vladimir M Moskovkin . See the following useful link: https://www.jica.go.jp/jica-ri/IFIC_and_JBICI-Studies/english/publications/reports/study/topical/approaches/pdf/higher_02.pdf

Ahmed Bakr, I can’t really comment, but it sounds reasonable! You could also classify them as “weaker” and “stronger”, implying that these are relative rather than absolute. Sometimes we get caught up in the statistics… try picking out one of the weak ones and try to understand what is going on in the real world, not from a statistical perspective - what is correlated with what, and what sorts of influences (in real life) might be weakening the relationship?

Best !!

AN

interested

Re: anxiety as a side effect of bicalutamide

THIS IS FROM WIKIPEDIA [paraphrased and abbreviated]: Side effects due to androgen deprivation include mild-to-moderate breast tenderness and enlargement in up to 80% of men, along with feminisation. Reduced body hair and muscle mass, feminine fat distribution, reduced penile length, and decreased semen volume can occur, along with hot flashes, sexual dysfunction, depression, fatigue, weakness and anemia. Bicalutamide monotherapy has also been associated with an increase in the rate of heart failure.

MY OPINION: in view of this side effect profile, depression, anxiety and id-percieved stress, in a percentage of subjects, is to be expected.

Stress-related intracellular hypothyroidism (IC), producing CFS-like symptoms including anxiety, confusion and cognitive loss, will result.

Incidentally, cardiomyopathy resulting from IC is the probable cause of the heart failure mentioned in the Wikipedia article.

I advise you to just be patient and be at rest since the decision is still in progress on your manuscript, it might end up in your favor

Dear colleagues, how is it possible to protect neurons, oligodendrocytes, any cell against injurious agencies that are poorly known, or if relevant evidence is not paid attention to, as shown at www.ms-info.net and in similar publications?

I think that the best way is keep the house especially the room of the patients clean and healthy. Not dusty, full of ash, smoke residu, spider web, bad humidity, and other poluttants. Sun light and fresh air are also very important.

Housework is important to help this kind of case.

Healthy plant-based foods may lower risk and severity of COVID-19.

Thank you

Till upto OmicronBA.1-BA1.1- B.A.2 variant -https://nature.us17.list-manage.com/track/click?u=2c6057c528fdc6f73fa196d9d&id=1400a357d2&e=5944515236.

Besides the ethics, this case report can be controlled and criticized by others officially, in order to be approved.

Nalidixic acid - A NSAID grs of drugs or pain killer .REF : en.wikipedia.org ( Image Source ) .

I personally believe that imaging examinations in covid should be rapid, simple and executable at the patient's bedside and therefore I believe that the most useful is LUS.

Unfortunately still today is used the chest X-ray that has been proven useless.

The purpose of LUS is to stage the pathology in order to predict its evolution, unfavorable or favorable. With LUS and blood gas analysis we can determine which patients should be discharged at home in a period when bed meals are scarce in all hospitals.

Dear Hamidreza Khalounejad , there are various types of modalities that can be beneficial for persons with MS.

I have explained all types with detailed information such as volume, repetitions, exercise selection, etc particularly during COVID-19 in my latest article, which you can find it here:

Dear Dr Sunny Chi Lik Au . See the following useful RG link:

Dear Eleas,

If I understand correctly your question is with respect to the chemical reactivity of an NCE for its target.

Most commonly high chemical reactivity is not seen as an advantage. First the molecule needs sufficient stability for shelf life, limit impurities... Then reactivity may lead to safety issues if this leads to reaction with proteins other than your intended target. A variation on this theme is also formation of reactive metabolites that can cause liver toxicity; this is linked to the original molecule having reactive features or groups that are made reactive when oxidized (oxygenated).

However, reactivity towards the intended target can be very effective for inhibition from covalent binding. This can for example allow to decuple PK and PD (prolonged PD depending on target turn-over). For this to be effective it needs to be specific: reactive "warhead" reacts only with the intended target when molecule specifically bound and not with relevant off-targets. An example of this you can read about is remibrutinib.

I would include some othre ideas related to: reponses, intraindividual variabilitiy, taste, enjoyable, pleasure

Evidence:

@ Anwar, TiO2 nanoparticles is an effective microbicide agents, which have the advantage of improved safety and stability compared to organic antimicrobial agents. Titanium dioxide is also used in most sunscreens to block UVA and UVB rays. It is also commonly used as pigment for pharmaceutical products such as gelatin capsules, tablet coatings and syrups.

Check https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555946/

Resistant exercises can tire MS disease quickly. This is an undesirable situation in patients with MS.

I recommend more ROM exercises and short-term isometric exercises.

Also check..

This depend on the drug bioavailability , way of excretion may be differ than that in animals all these should be taken in consideration

Publishing on a particular area does not require one to necessarily have a certificate in that area. However, if you find yourself to be inadequately equipped with the requisite knowledge to do a good job in that specific field, you may overcome that by collaborating with someone with that knowledge so that together you can bring out a very good and scientific work.

Former USSR traditional lecturers with great academicians, undoubtedly those times won't be repeated anywhere, Prof. Henrik G.S. Arvidsson

The best MS exercises are aerobic exercises, stretching, and progressive strength training. Aerobic exercise is any activity that increases your heart rate, like walking, jogging, or swimming. You just don't want to overdo it—it should be done at a moderate level. https://www.pennmedicine.org/updates/blogs/neuroscience-blog/2017/may/multiple-sclerosis-and-exercise

The change in the level of uric acid and biochemical parameters in a patient with an identified case of desminopathy is presented in the article https://www.researchgate.net/publication/357311034_CHANGE_IN_REDOX_STATUS_AND_BIOCHEMICAL_PARAMETERS_IN_PATIENT_WITH_DESMINOPATHY_T341P_SEVERAL_YEARS_AFTER_DISEASE_SYMPTOMS_ONSET

Have a look at this useful RG link.

Hello. This topic is not exactly my field, so I cannot give you a satisfactory answer. I will be happy to follow all the news and discussions in this field.

Regards, Zlata Felc.

Please see these links for info on health and consequences of COVID-19 for people with disabilities:

Hi Liliana,

Yes, you are right. There is a plenty of discussion in this area. Please find below some guidelines.

as of my knowledge it is usually the cause of negligence of health workers due to lack of knowledge or they may not able to treat disease properly or they will take less care about patient, it could be in the areas of diagnosis, drug administration, health management, therapy. now a days people are forgetting humanity.

Dear Mostafa Elsersy, would you please add the history and dermatological examination findings?

Dear Rafi Al-Ani Do have a look at the following discussion here on RG: https://www.researchgate.net/post/Beware_of_these_kinds_of_emails

Conclusion: avoid.

Best regards.

please eloborate what you mean by bloodlessness ? If you are talking about anemia, then a balanced diet and vitamin supplements are needed.

(only one point). maybe there is a difference to state how the image was made and how the scale could be, even though the scale bar is almost approximately at the same level each time. STM, (scanneling Tuning Microscope, false colour, the blacvk and white images, maybe the microscope taken with this 10x, objectives, and so on.All these give ideas on how the scale bars are.... even though I think it is ignored data.

Have a look at this useful link.

You can publish your study protocols in any of the journals which has scope of your title. Example: BMC, BMJ Open, Clinical Trials,… etc.

Please have look on our(Eminent Biosciences (EMBS)) collaborations.. and let me know if interested to associate with us

Here is our lab page: https://www.eminentbio.com/home/members

Here is our publication: https://www.eminentbio.com/home/Publication

Our recent publications In collaborations with industries and academia in India and world wide.

Our Lab EMBS's Publication In collaboration with Universidad Tecnológica Metropolitana, Santiago, Chile. Publication Link: https://pubmed.ncbi.nlm.nih.gov/33397265/

Our Lab EMBS's Publication In collaboration with Moscow State University , Russia. Publication Link: https://pubmed.ncbi.nlm.nih.gov/32967475/

Our Lab EMBS's Publication In collaboration with Icahn Institute of Genomics and Multiscale Biology,, Mount Sinai Health System, Manhattan, NY, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/29199918

Our Lab EMBS's Publication In collaboration with University of Missouri, St. Louis, MO, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/30457050

Our Lab EMBS's Publication In collaboration with Virginia Commonwealth University, Richmond, Virginia, USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211

Our Lab EMBS's Publication In collaboration with ICMR- NIN(National Institute of Nutrition), Hyderabad Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/23030611

Our Lab EMBS's Publication In collaboration with University of Minnesota Duluth, Duluth MN 55811 USA. Publication Link: https://www.ncbi.nlm.nih.gov/pubmed/27852211

Our Lab EMBS's Publication In collaboration with University of Yaounde I, PO Box 812, Yaound�