Science topic

Medicinal Inorganic Chemistry - Science topic

Explore the latest questions and answers in Medicinal Inorganic Chemistry, and find Medicinal Inorganic Chemistry experts.
Questions related to Medicinal Inorganic Chemistry
  • asked a question related to Medicinal Inorganic Chemistry
Question
3 answers
We don't have access to rota vapor but our solution requires removal of DMSO. And my product compound happens to be soluble in water and just might dissolve and get lost in the presence of moisture. is there any other method other than rota vapor and water washing followed by lyophilization?
Relevant answer
Answer
 I would do SGC either reverse column with C-18 or regular silica gel column should separate your compounds from DMSO. I have had several times DMF and DMSO mixtures with my compounds and able to separate it by SGC unless you recrystalize your compound from EtOH. 
  • asked a question related to Medicinal Inorganic Chemistry
Question
14 answers
A chichibabin reaction of aromatic aldehyde with aromatic ketone and ammonium acetate was charged in acetic acid. Upon completion of reaction, it was washed with cold water. After filteration, the obtained precipitates were found not soluble in DCM, dioxane, benzene, THF, Acetic Acid, MeOH, ETOH, DMSO, DMF,ETOAc, Hexane. Could someone be kind enough to guid me how to make it solubilize so that i can moniter it on TLC for purity purpose? Thanks in advance. 
Relevant answer
Answer
Dear Tahseen, you can try with toluene, or with mixing of solvent, an example is MetOH-DCM 10%, but if it's a polymer the product is less soluble. 
  • asked a question related to Medicinal Inorganic Chemistry
Question
5 answers
What are the products of AgNO3+CO(NH2)2 in 500 C? And how to balance the equation as stoichiometry?!?
Relevant answer
Answer
I agree with Alexey, in the end you will have a mixture of nitrogen-containing gases (NO, N2, N2O, NO) depending on the temperature. 
  • asked a question related to Medicinal Inorganic Chemistry
Question
5 answers
I extracted mucus from earthworms (concentration: 10mg/L, Ionic strength: 1mM via CaCl2), and stored in 4 degree Celsius. Then, after 2 weeks, some insoluble flocculations (fibrous-like) were observed in solution. What are those? and how long I can keep the biological solution in low temperature (4 degree Celsius)?
Relevant answer
Answer
Dear Behroos
If your extracted mucus have yellow color, it means that you have a mixture of mucus with some coelomic fluid( yellow) ,so you must check the coelomic fluid reactions( oxidation and ...) during this period too.
(Based on results that i saw in laboratory, always we have a mixture of mucus and coelomic fluid...)
  • asked a question related to Medicinal Inorganic Chemistry
Question
3 answers
Need some help on Gold Chemistry !!
Relevant answer
Answer
not cluster but thiol complex (Au3+(HS-Et-OH)3). Plz, add reducing agent such as ascorbic acid, borohydride, hydrazine, ...)
  • asked a question related to Medicinal Inorganic Chemistry
Question
10 answers
As Gluconolactone is unstable in aqueous solution. I would like to know if do you have any suggestions for the quantification of gluconolactone in pharmaceutical drugs.
Sincerely yours.
Relevant answer
Answer
In the sample prep, convert all gluconolactone into gluconic acid and You may be able to quantify as gluconic acid  by  HPLC using columns suitable for organic acids. ( some are with Ion exchange column and some with RP HPLC columns).
If you would like to quantify gluconolactone and gluconic acid simultaneously, you may need to use an alcohol and acetonitrile mixture as mobile phase and silica column. Use alcohol to prepare the sample.
Alternatively you may need to try silylation and quantify by Gas chropatography
  • asked a question related to Medicinal Inorganic Chemistry
  • asked a question related to Medicinal Inorganic Chemistry
Question
5 answers
I have a mixture that is dissolved in 25ml DMF, the product has pyrozyl-benzoimidazole moiety which seems lipophilic. do u have any suggestions besides Rota evaporation?
Relevant answer
Answer
Adding to Purujit's reply: There are other ways of getting about with large quantities of DMF.
1. Try forming an azeotrope with either toluene, heptane.
2. A vacuum distillation with the collector under very low temp (-78 C) and your sample at about 60 C would work good.
3. You can also use a lyophilizer to get rid of DMF- but obviously not the best of the options considering the pump life.
  • asked a question related to Medicinal Inorganic Chemistry
Question
4 answers
I did not get a product sheet with it so i googled other product sheets for cisplatin(Which has the same molecular formula) and they mentioned I can dissolve it with DMF with "gentle heating".
I'm trying to contact the company but meanwhile does anyone how to exactly dissolve this drug? Do i need to vortex it? is it okay to be handled in at Room temperature for the duration of me dissolving it as it does mention "gentle heating"but they do not mention what is considered as "gentle heating"
Relevant answer
Answer
Dear Sarah,
Take a look at a related post (link below), maybe some of the answers could be of help.
Also, please, be ware that cisplatin loses some or all of its activity when dissolved in solvents such as DMSO or DMF that form complexes with Pt2+. A paper that explicitly dealt with that:
Best regards,
Niko
  • asked a question related to Medicinal Inorganic Chemistry
Question
8 answers
Dear All,
I want to study the reduction of platinum IV Prodrugs Using GSH and ASA. Although there are plenty of research articles available on this topic, the problem is that my Platinum IV complex is insoluble in water and has a solubility in DMSO and ACN. So what's your opinion? If I perform the studies in DMSO using 1:25 (Pt:GSH) at different time intervals and studied by NMR, does this process mimic the reduction that actually happens in cellular conditions? As I am afraid it's not.
So can anyone suggest the experimental protocol I should follow? Gratitude
Relevant answer
Answer
Mathew is right - DMF should be preferably used with water: DMF is a good solvent and in this quality it is comparable with DMSO, but 100% DMF would unlikely make a good environment for your reaction for several reasons, including your interest to mimic cellular (water-based) reaction environment. So I would try the lowest concentration of DMF in water, at which your Pt(IV) complex and all other reaction components are still soluble. If DMF does not work, you have other choices of highly polar solvents that are likely to dissolve your polar Pt(IV) complexes: my first choices would be MFA/water, various glycol ethers in water, or PEG400/water  (the last one is often used in pharmaceutical formulations). I am a bit skeptical  about using detergents (surfactants) as solvents for water-insoluble inorganic compounds (detergents are good to solublize hydrophobic proteins and lipids that are otherwise difficult to dissolve in water-based environment, but your compounds are different in that they are water-insoluble polar inorganics).
I would also be somewhat concerned about using GSH as a reducing reagent for Pt(IV). In the excess of GSH, Pt(II) complexes produced in the reaction can react with GSH and form very stable and anticancer inactive Pt-GSH complexes. In fact, under some circumstances GSH may displace all other ligands in Pt(II) complexes due to strong trans effect of Pt-S bond (destabilization of bonds in trans position to Pt-S bond). This does not happen readily in cells even though there is an excess of GSH, because other cellular S-nucleophiles compete with GSH in interacting with Pt(II). However, there is a risk that GSH will react with Pt(II) complexes formed in your reaction and produce these stable (even polymeric) Pt-GSH complexes, because other kinetically preferred S-nucleophiles compiting with GSH will not be available. 
  • asked a question related to Medicinal Inorganic Chemistry
Question
3 answers
Just before starting the experiment, should I check if the singlet oxygen release power of the oxidants is still ok?
Oxidation: 4 mol/L KI.
Relevant answer
Answer
Now, I do not understand  how is a singlet oxygen related to  taurine chloramine. Chloramine is a moderate oxidant under neutral pH and may react (as well as  a singlet oxygen) with numerous compounds in a blood sample. AS far as I understand you should do control experiments.
  • asked a question related to Medicinal Inorganic Chemistry
Question
3 answers
How can I synthesize sulfa drug and schiff base?
Relevant answer
Answer
...for Zn(II) complexation with Schiff's bases you woulld try also the conditions in :
4. Structural and spectroscopic study of novel Ag(I) metal–organic complexes with dyes – Experimental vs. theoretical methods, Inorganica Chimica Acta, Volume 382, 2012, 96-104, M. Lamshöft, C. Stolle, J. Storp, B. Ivanova, M. Spiteller
Nevertheless that the report is on AgI-complexes, with Zn(II) also it yielded successful results. Furthermore the Zn(II) is with stable oxidation state, therefore, there has not the usual redox process of the metal ion like those of AgI/AgIII/Ag0.