Medical Writing - Science topic

Background Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare, disabling genetic disorder characterized by congenital malformations of the great toes and progressive heterotopic ossification of soft and connective tissues. Assiduous attention to the unmet needs of this patient community is crucial to prevent potential iatrogenic harm and...

Background Dysregulated interleukin (IL)-6 production can be characterised by the levels present, the kinetics of its rise and its inappropriate location. Rapid, excessive IL-6 production can exacerbate tissue damage in vital organs. In this situation, therapy with an anti-IL-6 or anti-IL-6 receptor (IL-6R) monoclonal antibody, if inappropriately d...

As part of the strategy for developing its editorial performance Tunis’Med’2030, based on productivity, quality and visibility, the journal «La Tunisie Medicale» (ISSN: 0041-4131, IeSSN: 2724-7031), focused on the identification of Tunisian champions of scientific medical writing, to invite them to submit editorials, describing the prospects for th...

A career talk about becoming a Medical writer within Scientific Communication.

Figure 1. (A) PSAID scores in completers and (B) percentage of completers with no swollen joints, no tender joints, no dactylitis and no enthesitis at baseline (BSL), month 3, 6 and 12 (M3, M6, M12). Conclusion: In this interim analysis of the REWARD study, patients completing 12 months of apremilast treatment were more likely to be biologic naïve...

Funding Acknowledgements Type of funding sources: Private company. Main funding source(s): This study was sponsored by Daiichi Sankyo, Inc. Medical writing and editorial support were provided by Atreju Lackey, PhD of AlphaBioCom, LLC, and funded by Daiichi Sankyo, Inc. Background/Introduction Once-daily edoxaban significantly reduced the risk of i...

This article discusses the nutritional needs of moderate and late preterm infants (born between 32+0weeks and 36+6weeks' gestation) and makes recommendations for best practice both while these infants are in hospital and when they are discharged into the community. These recommendations were derived following a roundtable meeting of a group compris...

Study questions What is the microbiome profile across different body sites in relation to the normal menstrual cycle (with and without hormonal contraception), recurrent pregnancy loss (before and during pregnancy, pregnancy loss or birth) and endometriosis (before, during and after surgery)? How do these profiles interact with genetics, environmen...

The United Nations Sustainable Develop ment Goals (SDG) call all UN member states – low-, high- and middle-income – to promote prosperity while protecting the environment. The 17 goals are part “of a shared blueprint for peace and prosperity for people and the planet.” The objective of SDG 4 Quality Education is “to ensure inclusive and equitable q...

The usual approach to Babylonian medical writings is to assume a monolithic corpus of data presented in either recipes, lists of drugs, or collections of symptoms for prognosis and diagnosis. Despite the lengthy period of documentation of Babylonian medicine, no attempt has been made to view the acquisition of Akkadian medical knowledge as a dynami...

Publication of a research article in medical journal is reflection of scholarly activity and academic credentials.1 History of medical writing dates back to very ancient times but in the contemporary era, medical writing has been changed a lot and also changing continuously with each passing day

This review describes the first medical article written by an author from Bosnia and Herzegovina. The article was published by Fr. Franjo Gracić (1740-1799), in Latin, under the title: “Analysis theorico-practica de viribus virus febriferi, pestiferi, atque serpentin”, and printed in Padua in 1795, translated as: “A Theoretical and Practical Presen...

Skilled academic/medical writing is critical to research communication. The fundamental sections of a scholarly manuscript are introduction, methods, results and discussion. The introduction of a medical manuscript is aimed at briefing readers on the clinical extent and public health context of the research problem. It must justify the essentialnes...

Background There is an increasing number of studies that infectious diseases consultations improve patients’ outcomes, but few studies have investigated the quality of consultations. The aim of this study was to identify important skills and attitudes for consultants to improve the quality of consultations. Methods We conducted our research in two...

Background Adults ≥ 50 years of age (YOA) are at increased risk of herpes zoster (HZ), a condition which can cause long-term pain and discomfort. In this analysis, we assessed the burden of pain associated with HZ and its interference with activities of daily living (ADL) in patients ≥ 50 YOA. Methods ZOE-50 (NCT01165177) and ZOE-70 (NCT01165229)...

Background 2-stage exchange (2SE) surgery is often used to treat chronic prosthetic joint infections (PJI). IDSA guidelines do not recommend oral antibiotic suppression after 2SE. However, a recent randomized trial suggested that oral antibiotics for 3 months after arthroplasty reimplantation may prevent recurrent PJI. Objective: To compare rates o...

Background Debridement, antibiotics, and implant retention (DAIR) is appropriate for select acute postoperative and hematogenous periprosthetic joint infections (PJIs). However, the optimal duration of antimicrobial therapy in patients treated with DAIR has not been defined. Therefore, we aimed to identify the ideal duration of parenteral and oral...

At the Research Quality Association (RQA), 14 attendees came together to discuss distributed manufacturing on May 4, 2021. A Trends in Biotechnology article called “Build a Sustainable Vaccines Industry with Synthetic Biology” provided the basis of discussion. Centralised manufacturing commonly practiced by the pharmaceutical industry is challengin...

Therapeutic options for metastatic CRC (mCRC) have changed significantly in recent years, greatly increasing the complexity of therapeutic decision-making. Although oncology guidelines have helped improve the care process, guidelines may also limit the flexibility to individualize in-clinic decision-making. This consensus paper addresses specific g...

Overview of Medical Writing: How to Make a Difference in Publications

Background Lipo-MERIT is an ongoing, first-in-human, open-label, dose-escalation Phase I trial investigating safety, tolerability and immunogenicity of BNT111 in patients with advanced melanoma. BNT111 is an RNA-LPX vaccine targeting the melanoma tumor-associated antigens (TAAs) New York esophageal squamous cell carcinoma 1 (NY-ESO-1), tyrosinase,...

Background Tumor infiltrating lymphocyte (TIL) products made from tumor digests showed a high overall response rate (ORR; 67%) and complete response (CR) rate (19%) and a safety profile consistent with lymphodepletion and high-dose interleukin (IL)-2 in a retrospective analysis of a single center experience of TILs for compassionate use treatment o...

This paper explores the problems of extraction and decryption of abbreviations from domain-specific texts in Russian. The main focus are unstructured electronic medical records which pose specific preprocessing problems. The major challenge is that there is no uniform way to write medical histories. The aim of the paper is to generalize the way of...

This is the review of a book edited by Taavitsainen and Hiltunen concerning their compilation work in the Corpus of Medical Writing.

Skilled scientific or academic writing is of great importance to research communication and journal publication ultimately. The four fundamental sections of a scholarly manuscript are introduction, methods, results and discussion. The discussion serves to interpret and analyze the study results in view of the existing body of evidence. Moreover, it...

In many developed nations, medical writing and editing is a well-established career path for doctors who are interested in publication. It is not possible, at present, to make a living doing this in India. However, with the increasing number of publications (in print and on the electronic media), medical books, promotions of drugs and devices, and...

Although India is the second-largest country in the world where the English language is spoken, we often use it incorrectly and tend to be verbose. When it comes to writing skills, we use convoluted phrases and complex words when simple ones would do. A medical paper does not need to be written in theatrical or Shakespearean English. We should expr...

Plain language summaries of peer-reviewed medical journal publications are a means of sharing research with a broad range of audiences and may improve the transparency, accountability, accessibility, discoverability, and inclusivity of medical research. There is currently an ongoing, industry-wide effort to establish consensus on plain language sum...

Oral pathologists or dentists in general opting for alternate career paths are very common nowadays. Financial security, lesser availability of jobs and work satisfaction are the most commonly observed reasons for this openness to switch career. While there is a multitude of alternate career options available such as medical writing and pharmacovig...

Writing health technology assessment (HTA) submissions is a challenging and rewarding area of medical writing, being part of the process of giving patients access to new medicines. Submission requirements differ between countries but all require clear communication of the new product's value. This article looks at the medical writer's role in UK an...

BackgroundandAim:While the prohibition on the dissection of the human body in Christian and Islamic culture prevented physicians from knowing the internal organs of the human body, Greek physicians and later, Muslim doctors tried to get acquainted with the shape and function of the organs through the dissection of animals. Galen dissected the pigs,...

This article examines why older people were particularly prone to suicide in Georgian England, and argues that their suicidality is best understood through the lens of the ‘ageing body’. By centring on the experiences of the suicidal, it proposes that suicide was not ‘medicalised’ in the way traditionally described in the historiography, being reco...

According to ancient data, numerous countries had different methods and traditions for dealing with animal ailments. In India, veterinary science has a 5000-year history. On different elements of veterinary care, such as health management of cattle, horses, and birds, there is codified veterinary knowledge in the form of medical writings and manusc...

In the course of his discussion of the origin of variations in skin colour among humans in the Descent of Man , Charles Darwin suggested that darker skin might be correlated with immunity to certain diseases. To make that suggestion, he drew upon a claim that seemed self-evidently correct in 1871, although it had seemed almost certainly incorrect i...

ABSRACT Background: English for medicine and academic purposes (EMAP) is believed tremendously significant for our medical students' academic and professional life. Although writing is underscored as the most challenging and valuable skills, our EMAP prospectus is based on an incorporated approach to the four language skills. Medical writing engage...

he pivotal role of scientific journals is to provide updated knowledge via distribution of new innovations and provision of future road map for research. Therefore, maintenance of quality standards for available data harbors great significance. This all becomes the jurisdiction of editors, who ensure preservation of all this on ethical grounds1. Th...

The term “crisis” in medical context is an important turning point or stage which occurs in some diseases and if not managed correctly, can become life threatening. Despite the use of the term in modern medicine, it was a much wider and sophisticated traditional medical concept. The first usage has been seen in the Greek writings of Hippocrates. In...

Background Despite multi-professional collaboration via consultation being increasingly important given the variety of disease diagnoses and treatment, the key elements as consultants remain unclear. The study aimed to identify the skills and attitudes that are important for consultants from the residents’ perspective so that they can be targeted a...

We are currently witnessing an immense proliferation of natural language processing (NLP) applications. Natural language generation (NLG) has emerged from NLP and is now commonly utilized in various applications, including chatting applications. The objective of this paper is to propose a deep learning-based language generation model that simplifie...

Background The safety and efficacy of the oral Janus kinase inhibitor upadacitinib (UPA) has been evaluated across a spectrum of patients with rheumatoid arthritis (RA) in the phase 3 SELECT clinical program. 1–6 Objectives To describe the long-term integrated safety profile of UPA relative to active comparators (cutoff date: June 30, 2020) in pat...

Background The efficacy and safety of upadacitinib (UPA), an oral Janus kinase inhibitor, in patients (pts) with active psoriatic arthritis (PsA) were demonstrated through 24 weeks in the phase 3 SELECT-PsA 1 and SELECT-PsA 2 placebo-controlled clinical trials. 1,2 Objectives To describe the long-term integrated safety profile of UPA relative to a...

Background Upadacitinib (UPA), an oral Janus kinase inhibitor, in combination with conventional synthetic disease-modifying antirheumatic drugs (csDMARDs), showed significant improvements in clinical and functional measures compared with placebo (PBO) up to 12 weeks (wks), in patients (pts) from China, Brazil, and South Korea with rheumatoid arthri...

Background While sexual function is impaired in a high proportion of patients with rheumatoid arthritis (RA), it is often neglected in patient care.¹ FINCH 1 (NCT02889796), FINCH 2 (NCT02873936) and FINCH 3 (NCT02886728) were Phase 3 studies to assess the safety and efficacy of filgotinib (FIL) for moderate-to-severe RA; patient-reported sexual fun...

Background In the INBUILD trial in subjects with progressive fibrosing ILDs other than idiopathic pulmonary fibrosis (IPF), nintedanib reduced the rate of decline in FVC (mL/year) over 52 weeks by 57% compared with placebo. Objectives To assess the rate of decline in FVC in subjects with RA-ILD in the INBUILD trial. Methods Subjects in the INBUIL...

Background In the SELECT-PsA 1 study, through 24 weeks (wks), once daily upadacitinib 15 mg (UPA15) and 30 mg (UPA30) showed improvements in musculoskeletal symptoms, psoriasis, physical function, pain, fatigue, and quality of life, as well as inhibition of radiographic progression in patients (pts) with psoriatic arthritis (PsA) and inadequate res...

Aims Treatment resistant depression (TRD) affects ≤20% of patients with major depressive disorder and is defined as failure to respond to ≥2 different antidepressants in the same major depressive episode (MDE). TRD patients’ outcomes are poor and real-world data from the UK are limited. The Treatment Resistant Depression in Europe Cohort was establ...

Publishing 101: Clinical Medicine Book

The clinical history is an official document that requires rigorous drafting, since it contains essential data about the patient and his condition; as well as thetreatment and evidence of his evolution. Due to the above, a program is necessary that organizes the stages the student goes through to learn to write it. Therefore, the objective of this...

The methods and results of systematic reviews should be reported in sufficient detail to allow users to assess the trustworthiness and applicability of the review findings. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement was developed to facilitate transparent and complete reporting of systematic reviews an...

The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement, published in 2009, was designed to help systematic reviewers transparently report why the review was done, what the authors did, and what they found. Over the past decade, advances in systematic review methodology and terminology have necessitated an update t...

Global literature is ever-growing and physicians rely on it for evidence-based decision making. Review articles summarize available literature and provide the current state of knowledge on a given topic. Various review types exist, the main ones being narrative and systematic reviews. The former are based on studies selected in an undefined manner....

A recently published nomenclature by a “Kidney Disease Improving Global Outcomes” (KDIGO) Consensus Conference suggested that the word “kidney” should be used in medical writings instead of “renal” or “nephro” when referring to kidney disease and kidney health. Whereas the decade-old move to use “kidney” more frequently should be supported when com...

The article discusses a case study employing medical writing for the development of skills, attitudes and values that are essential for the healthcare worker’s identity. The emphasis is made on empathy, communication skills and communicative tolerance. The authors argue that these attitudes can be enhanced in the academic curriculum of medical univ...

Ibn Sina (980-1037 AD), Latinized as Avicenna was a Persian scholar, physician, scientist and medical writer whose works had a lasting influence on medical education for more than seven centuries. He is known to have authored more than 400 books, of which many could not be preserved. His most famous treatise is Al-Qanoon Fil Tibb (The Law in Medici...

Two disease-descriptions featured in ancient literature (skolekosis and phthiriasis) have long been interpreted as evidence of medical illness, but this paper argues that they should be understood as strictly literary phenomena; they do not describe any diseases that occurred in the ancient Mediterranean world. The lack of correspondence between na...

While intensifiers are primarily associated with informal spoken registers, they serve important interpersonal functions also in more formal registers like academic prose. The use of intensifiers in scientific writing has accordingly been explored in Present-Day English, and previous studies have also investigated diachronic changes in this registe...

This chapter traces melancholia from the early nineteenth century, when its nosological status as an independent disease category was contested, up until the 1860s. At this time, the view that insanity could be chiefly of the emotional kind, that is, largely without delusion of thought, was rapidly gaining ground among European medical writers. Thi...

s are critical in medical contexts. They contain formulaic building blocks called Lexical Frames (LFs), which are high-frequency word sequences with variable slots that can be formed around collocation nodes. LFs are abundant in written academic discourse, and , for this reason, have great importance for the production of abstracts. Extensive resea...

Every time a paper is submitted to the journal, we realize the effort and amount of work it takes for performing the study, writing, formatting, and submitting the paper for peer review. However, how many of these papers are suitable for publication? Medical writing considerations, including an understandable text that does not confuse reading, for...

This open access book studies breath and breathing in literature and culture and provides crucial insights into the history of medicine, health and the emotions, the foundations of beliefs concerning body, spirit and world, the connections between breath and creativity and the phenomenology of breath and breathlessness. Contributions span the class...

Background Older and immunocompromised adults are at increased risk for herpes zoster (HZ) and often experience persistent, severe HZ-related pain, impacting their quality of life and activities of daily living. High vaccine efficacy (VE) of the adjuvanted recombinant zoster vaccine (RZV) in preventing HZ and reducing severe and clinically signific...

for research poster presented at the (2015) Fourth Fascia Research Congress, Washington D. C., USA. Available at: https://www.fasciacongress.org/2015/Abstracts/20_Adstrum.pdf BACKGROUND Research is constrained by its theoretical perspective, methodological approach, and research methods. Quantitative research is invaluable when formulating a techni...

Aims This report reviews major laws, acts and regulations of social benefits and services for individuals with disabilities, focusing on cerebral palsy in the five Nordic countries. It summarizes the available benefits and services and the re-application process and provides comparative analyses among the countries. Methods Published reports, arti...

The COVID-19 virus diffusion is, nowadays, global and any clinical trial is potentially affected by the direct and indirect consequences of the COVID-19 during the pandemic. Any step, from protocol design to result's disclosure, needs to be revised to assess the impact of the COVID-19 on the study, evaluate the potential risks, and establish a miti...

Background There is no shortage of books, chapters and papers on the history of stroke focusing predominantly on the last 150 years and enumerating endless “milestones”. Instead of adding another article to this body of knowledge, this essay aims at ensuring awareness for the “big picture”, the “grandes routes”, and the “striking breakes” without o...

Introduction: Patients (pts) with CLL may be at particular risk of severe COVID-19 given advanced age and immune dysregulation. Two large series with limited follow-up have reported outcomes for pts with CLL and COVID-19 (Scarfò, et al. Leukemia 2020; Mato, et al. Blood 2020). To provide maximal clarity on outcomes for pts with CLL and COVID-19, we...

Background Tumor mutational burden (TMB), as measured by exome or panel sequencing of tumor tissue (tTMB) or blood (bTMB), has been identified as a potential predictive biomarker for treatment benefit in patients with various cancer types receiving immunotherapy targeting checkpoint inhibitors (e.g. PD-1, PD-L1, CTLA-4). However, significant variab...

Background IDO-1 inhibitors have shown antitumor activity in combination with immunotherapeutic agents in multiple cancers. KHK2455 is a novel and selective oral IDO-1 inhibitor. KHK2455 inhibits IDO-1 apo-enzyme, with long-lasting and potent activity. Mogamulizumab is an anti-C-C chemokine receptor 4 (CCR4) monoclonal antibody that has shown syner...

Background Platinum-based regimens, such as FOLFOX (fluorouracil [5-FU], leucovorin, oxaliplatin), are recommended standard of care first-line options in metastatic colorectal cancer (CRC). Maintenance therapy with a less intensive treatment regimen in metastatic CRC patients who do not progress during intensive first-line platinum–based induction...

The early-classical and classical Āyurvedic compendia of Caraka, Bhela, Suśruta, and Vāgbhaṭa contain mutually related and supplementary classification systems concerning the charac¬ter or natural constitution of human beings that are respectively based on medical, psychological, and physical conceptions. Of these, a specific medical classification...

Objective: In Hebrew online health communities, participants commonly write medical terms that appear as transliterated forms of a source term in English. Such transliterations introduce high variability in text and challenge text-analytics methods. To reduce their variability, medical terms must be normalized, such as linking them to Unified Medi...

Background: The use of professional medical writers (PMWs) has been historically low, but contemporary data regarding PMW usage are scarce. In this study, we sought to quantify PMW use in oncologic phase III randomized controlled trials (RCTs). Methods: We performed a database query through ClinicalTrials.gov to identify cancer-specific phase II...

I’ve been a medical writer and author’s editor for 45 years. I have read the instructions for authors in dozens of medical journals. I know what authors (and author’s editors) think of these instructions, at least among those who know that journals actually have instructions for authors. For almost as long, I’ve been a member of four professional s...

One type of clothing system used in the English Civil War, more common amongst cavalrymen than infantrymen, was the linen shirt, wool waistcoat and buff-coat. Ballistic testing was conducted to estimate the velocity at which 50% of 12-bore lead spherical projectiles (V50) would be expected to perforate this clothing system when mounted on gelatine...

This research has thrown up many questions in need of further investigation.There was an expressive quantitative-qualitative research, which a common investigation form was used in.The dialogue item was also applied to discover if the contributors asserted the media-based attitude supplements their learning of academic English writing classes or no...

Prescribing (writing medication orders) is one of residents’ commonest tasks. Superficially, all they have to do is complete a form. Below this apparent simplicity, though, lies the complex task of framing patients’ needs and navigating relationships with them and other clinicians. Mistakes, which compromise patient safety, commonly result. There i...

Learners of a foreign or second language are bound to make errors initially. A study, classification and analysis of the errors help to identify the types that are common. Therefore, teachers can focus on dealing with identified errors and ensure that learners avoid committing them. However, when such errors are committed by medical students when w...