MDA - Science topic

Premenopausal women diagnosed with cancer may suffer from ovarian toxicity, which affects their quality of life. Cisplatin (CIS) is an effective chemotherapeutic drug used for different types of tumors. However, CIS has been reported to cause ovarian toxicity. Aberration of the PI3K/AKT signaling has been implicated in CIS-induced ovarian toxic eff...

Introduction: Recovery is a vital component of physical activity, serving to restore the body’s physiological equilibrium after intense exertion. However, effective and efficient models of recovery therapy remain underreported in current literature. Objective: This quasi-experimental study aimed to examine the effects of ice bath therapy following...

Background: Cigarette smoking is a well-established risk factor for cardiovascular disease (CVD), with oxidative stress and lipid profile alterations playing critical roles. This study aimed to evaluate the impact of smoking on cardiovascular risk markers, including apolipoprotein A1/B (Apo A1/Apo B) ratio, oxidative stress, total antioxidant capac...

Wildfire smoke often aggravates the ozone (O3) pollution and negatively affect crop yields. To date, the global impact of fire-sourced O3 exposure on crop yields still remained unknown. To address this issue, a multi-stage model was developed to quantify the global wildfire-induced ambient O3 concentrations in the future scenarios. The results sugg...

Objective This study aims to evaluate the effects of vitamin D supplementation on glycemic control, insulin sensitivity, and pregnancy outcomes in patients with gestational diabetes mellitus (GDM) undergoing dietary therapy. Methods This is a retrospective cohort study that included 98 patients diagnosed with GDM according to the IADPSG criteria....

This study investigated the structural changes and molecular mechanisms induced by the oxidation of pork myosin by malondialdehyde (MDA). The effects of varying MDA concentrations on carbonyl content, sulfhydryl content, disulfide bond content, surface hydrophobicity, Ca²⁺‐ATPase activity, free ammonia content, UV–visible spectral characteristics,...

Drug-Induced Hepatitis (DIH) is a liver function disorder caused by the use of hepatotoxic drugs, which can affect liver metabolism acutely or chronically. A new paradigm suggests that natural-based treatments, such as sea cucumbers, have potential as therapy due to their superior antibacterial bioactivity. This study aims to evaluate the effect of...

Sixty-one horses were included in this study and classified into three groups based on the severity of colic, assessed by heart rate, oral mucous membrane color, and abdominal distension. The groups consisted of a strangulating colic (SC) group (n=21), a non-strangulating colic (NC) group (n=20), and a control group (n=20) of randomly selected heal...

This study investigates the ecophysiological adaptations of Spondias tuberosa (umbu) trees across two contrasting ecological zones in northeastern Brazil: tropical wet and tropical arid ecosystems. We assessed their adaptive strategies to fluctuating water availability by analyzing photosynthetic efficiency, water status , chlorophyll fluorescence...

This study aimed to assess the impact of Ganoderma lucidum supplementation (200–11,200 mg/day, 1–24 weeks) on health‐related indices in populations including healthy, at‐risk, and chronic disease individuals. A systematic review and meta‐analysis were conducted using data from EMBASE, PubMed, Web of Science, and Scopus up to August 2024. Pooled ana...

Myocardial ischemia–reperfusion injury (MIRI) is an injury mechanism of myocardial infarction, related to ferroptosis and glycolysis. Lactate produced by glycolysis promotes protein lactylation. This study aimed to investigate the correlation between glycolysis, ferroptosis, and GPX4 lactylation in MIRI. Hypoxia/reoxygenation (H/R) increased glucos...

Lead (Pb) pollution poses a long-term threat to forest ecosystems, particularly in mountainous areas affected by atmospheric deposition. This study examined the physiological and biochemical responses of juvenile Pinus sylvestris L. and Picea abies (L.) H. Karst seedlings to low concentrations of lead nitrate during early development. Treatments si...

Plastic waste, particularly polyethylene (PE) plastic bags and bottles, poses a significant environmental problem and health risk when degraded into microplastics. Recent atmospheric microplastic pollution increases inhalation exposure, necessitating a study on toxicity in the lungs. However, the inhalation toxicology of PE micro-plastics is poorly...

Background Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease in childhood, but its outcomes are still difficult to determine. We aimed to obtain outcome measurements of disease activity, functional capacity, disease damage, and therapeutic response, at one-year follow-up study on a real-life basis. Methods An observational J...

Chronic kidney disease (CKD) presents a significant global health concern, often leading to complications such as renal failure and cardiovascular issues. Alternative therapies based on medicinal plants are the focused area for the management of CKD. The present study focuses on the impact of Vetiveria zizanioides extract and its terpenes‐rich oil...

Ischemia–reperfusion (I/R) damage remains a major problem in surgery, primarily based on high oxidative stress generated during the reperfusion process. Mitochondria are significantly affected, their metabolic and energetic processes are impaired, and the redox system is out of balance. Regulation and restoration of the redox balance by oxidative p...

Iron deficiency is a significant abiotic stress that hampers plant growth and productivity, threatening food security. While plants employ physiological and biochemical mechanisms to cope with iron deficiency, these adaptations often come at the cost of growth. Iron nanoparticles (Fe-NPs) have garnered attention in agriculture due to their eco-frie...

A significant issue facing the world today is the antibiotics pollution of agroecosystems. Chlortetracycline (CTC) and oxytetracycline (OTC) are frequently detected antibiotics in soil. However, little is known about their ecotoxicological effects on crops. Here, the potential adverse effect of CTC and OTC individually and in combination on germina...

Background The aim of this study was to evaluate the health beliefs towards exercise, sustainable healthy eating behaviors and adherence with the Mediterranean Diet (MDA) among female university students. Methods The participants were female university students (N = 503). The study evaluated the general characteristics of individuals using the Hea...

In recent years, plant-based foods have gained attention as alternatives to animal-based foods due to notable antioxidant properties and health benefits. This study aimed to explore the antioxidant potential of a plant-based beverage (PB) composed of corn silk, astragalus, barley grass and Arctium lappa root, focusing on the efficacy in mitigating...

This chapter introduces a simplified and efficient approach to dimensional analysis, namely the so-called modern dimensional analysis (MDA). MDA is a simple, safe and user-friendly version of the dimensional methods that are currently widely applicable to several engineering problems, such as heat transfer, load-bearing capacity, as well as fire pr...

This study aimed to investigate the role of Sirt1 in the transition from depressive disorder (DD) to Alzheimer’s disease (AD), focusing on the regulation of inflammatory factors and oxidative stress through modulation of acetylation substrates. Male C57BL/6 and APP/PS1 mice were used to establish a mouse model of chronic unpredictable mild stress (...

Background Radiation exposure of sensitive organs during radiotherapy merits extraordinary consideration, particularly when the concern is about fertility. Although alpha-tocopheryl (vitamin E) is a potent antioxidant, many studies have demonstrated the radioprotective impact of alpha-tocopheryl acetate ester, emphasizing its antioxidant and anti-a...

Background and Purpose: Oxidative stress and reproductive dysfunction have been linked to petroleum exposure. This study investigated the protective effects of honey on oxidative stress markers, reproductive hormones, and ovarian histology in female Wistar rats exposed to gasoline vapor. Methods: Fifty-six female rats were randomly divided into sev...

Purpose The objective of this investigation was to produce fermented solid-state products of Salvia miltiorrhiza Bunge (SMB) utilizing Shiraia bambusicola Henn. (FSSMB). Additionally, it was intended to further explore toxicity-reducing potential and antioxidant effects of FSSMB ethanol extract against H2O2-induced oxidative stress in rat pheochrom...

This study delves into the intricate and multifaceted factors driving state-level college and university closures, leveraging publicly accessible variables through a Generalized Linear Model (GLM) analysis, in contrast to Multiple Discriminant Analysis (MDA). The analysis identifies key determinants of closures, including institutional endowment, t...

Background: Undergraduate healthcare students are future frontline communicators in India’s effort to eliminate lymphatic filariasis (LF) through Mass Drug Administration (MDA). This study assessed their perception, and practices regarding LF and MDA in an endemic tertiary care setting in Eastern India. Methods: A cross-sectional survey was conduc...

As important immune cells in innate immunity, natural killer (NK) cells are closely associated with the progression of Alzheimer’s disease (AD). Hypoxia has been considered as a critical factor that influences AD development, but the regulating effects and underlying mechanisms of hypoxic NK cells in AD progression have not been studied. Herein, ou...

Ischemic stroke remains a leading cause of morbidity and mortality worldwide. Current therapeutic approaches for ischemic stroke are limited, particularly in targeting the interconnected mechanisms of neuroinflammation and oxidative stress. There is a critical need for effective neuroprotective agents that address these pathways to mitigate I/R-ind...

Endothelial cell dysfunction is a fundamental injury of atherosclerosis cardiovascular disease (ASCVD), closely linked to ferroptosis, which is a novel type of cell death induced by iron-dependent lipid peroxidation. Several clinical trials have suggested that empagliflozin, a selective inhibitor of sodium glucose co-transporter 2, reduces the risk...

Introduction Animal reproduction is a highly complex process influenced by numerous factors, and previous study has suggested that Hungatella hathewayi (HH) may have potential benefits for swine reproduction. Building on these findings, the objective of this study was to investigate the effects of HH supplementation on sows’ hormone levels, antioxi...

Background Schistosomiasis remains a significant public health issue in Uganda, particularly among fishing communities. This study, nested within a larger community-based study (ADOPT) on introducing a new child-friendly praziquantel formulation for schistosomiasis, arpraziquantel, explored enablers and challenges perceived by district health autho...

This paper introduces a novel conceptual and mathematical framework for modeling complex adaptive systems, termed Morphological Dynamic Agent (MDA) systems. In this model, autonomous entities ("agents"), characterized by fluid and variable morphologies, navigate a given space, forming temporary connections and exchanging information upon interactio...

Purpose Acute lung injury (ALI) is a serious clinical respiratory disease, but there are few effective drugs for ALI. As a natural product, Elsholtzia bodinieri Vaniot is used as a drink and medicine in ethnic minority areas of Southwest China. In previous studies, we found that E. bodinieri Vaniot methanol extract (EBE) was effective against ALI....

Background Alopecia is a global dermatological challenge. Adipose-derived stem cells (ADSC) show therapeutic potential, but their mechanisms in promoting hair regrowth, particularly under oxidative stress conditions, remain unclear.. Objective To investigate ADSC's role in promoting hair regrowth by mitigating oxidative stress. Methods Using H₂O₂...

This study explored the partial substitution of cassava starch with Peruvian maca flour in mortadella formulations, aiming to develop a healthier, clean‐label meat product by increasing antioxidant activity and reducing synthetic additives. Formulations with varying proportions of cassava starch and maca flour were evaluated for their physicochemic...

Background: Asthma is a chronic inflammatory airway disease in which oxidative stress and antioxidant imbalance play a critical role in disease progression and therapeutic response. This study aimed to evaluate oxidative stress and antioxidant status in relation to asthma control levels. Methods: A total of 106 patients admitted to the Clinical Hos...

Sepsis is the primary cause of mortality after infection and is considered a global health issue. This study aimed to investigate whether quercetin may have any potential nephroprotective effects during renal injury induced by sepsis. 40 male albino Swiss mice were divided into 4 groups of 10 mice each. Normal control groups include mice that clear...

Chitosan coatings enriched with Chlorella vulgaris hydrolysates were evaluated for their effectiveness in preserving rainbow trout (Oncorhynchus mykiss) fillets during refrigerated storage at 4°C ± 1°C. Alcalase‐hydrolyzed C. vulgaris exhibited potent antioxidant activity (IC50: 0.30 mg/mL; IC80: 0.61 mg/mL). These concentrations were incorporated...

Picroside II (Pic II) has been used to treat many skeletal diseases. Postmenopausal osteoporosis (PMOP) is a serious skeletal disease that significantly threatens the health of postmenopausal women. We aimed to explore the roles and mechanisms of Pic II in PMOP. PMOP models were established by performing bilateral ovariectomy in rats and stimulatin...

Dromedary camels thrive in arid regions and play a crucial role in meat, milk, and labor production. The transition period around parturition impacts maternal and neonatal health by altering antioxidant capacity and increasing oxidative stress. This study investigated the relationship between the transition period and antioxidant capacity in dromed...

Colon cancer is one of the most prevalent cancers worldwide and the second leading cause of cancer-related deaths. The goal of the present study was to investigate the role of Prodigiosin (PG) in promoting programed cell death in irradiated Caco-2 colon cancer cells. We examined the extent to which PG disrupts the BCL-2/caspase-3 and PPAR-γ signali...

Background and Objectives: Methotrexate (MTX) is widely used in clinical settings but is often associated with hepatotoxic side effects, including oxidative stress, inflammation, and fibrosis. Novel therapeutic strategies are needed to mitigate MTX-induced liver injury. This study aimed to evaluate the hepatoprotective effects of ivermectin in a ra...

Psoriasis is a chronic inflammatory skin disorder that is triggered by immune-mediated, genetic, and environmental factors. Moxifloxacin is a fluoroquinolone antibiotic with extended non-expected anti-inflammatory and immune-modulating effects. This study aims to investigate the possible influence of two different concentrations of moxifloxacin emu...

PPARγ is a regulator of cellular differentiation and damage and a catalyst of lipid peroxidation, while its agonists, Thiazolidinediones, treat diabetes and cancer in humans. The molecular mechanism of therapeutic PPARγ is not fully understood. Rheum ribes is known for its healing effects in cancer and diabetes. On the other hand, the mechanisms un...

The present study aimed to develop a protocol for hairy root induction from Dracocephalum moldavica L.leaf explants and evaluate the effects of iron nanoparticles (Fe NPs) (0, 250, 500 and 1000 ppm), copper nanoparticles (Cu NPs) (0, 25, 50 and 100 ppm), and the combination of both (Fe/Cu NPs) on the antioxidant capacity, phenolic, flavonoids and r...

Traditional freezing techniques damage blueberries by forming large ice crystals, thereby limiting their freshness.This study utilized an artificial neural network (ANN) to optimize the parameters of high-voltage pulsed electric field (PEF)-assisted freezing and compared it with traditional freezing methods.The results showed that pulsed electric f...

This study investigated the potential of wasabi extract (Eutrema japonicum) as a natural substitute for sodium nitrite in sausage production, focusing on its bioactive compounds. The chemical composition of the wasabi extract was analyzed using GC-MS. Sausages were prepared with equivalent of concentrations of wasabi extract (W), sodium nitrite (SN...

Annual ryegrass (Lolium multiflorum Lam.) cultivars, including Angus No.1, Abundant, Bolt, Jumbo, Tetragold, Barwoltra, and Diamond T, are widely cultivated in China for forage production. However, drought stress severely limits their yield and quality. This study investigated the drought tolerance mechanisms of these cultivars under 14-day extreme...

Asthma is a chronic inflammatory disorder of the airways, marked by hyperresponsiveness and oxidative stress. Despite advancements in pharmacotherapy, side effects and limited efficacy drive the search for botanical alternatives. This study investigates the immunomodulatory and antioxidant properties of aqueous extracts of Euphorbia hirta and Lactu...

We investigated the effects of PEG-induced drought on the antioxidative mechanisms of Crocus sativus L. and the mitigating effects of PEN on drought tolerance. Contents of H₂O₂ and MDA in fibrous roots were considerably lower than those in leaves and were attenuated by PEN pretreatment. Activities of CAT, SOD, and POX were significantly higher in f...

Background: Breast cancer (BC) is one of the most malignant types of cancer in women. Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor prognosis and high recurrence and invasive metastasis rates. Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent accumulation of reactive oxygen species (ROS...

The medium‐chain fatty acyl‐CoA synthetase‐5 (ACSM5) plays a crucial role in the development of some cancers. However, its impact on liver cancer is still not clear. In this study, we found that the proliferation ability of LM3 and HepG2 cells was significantly inhibited after ACSM5 was overexpressed, and this change was blocked by the ferroptosis...

Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, particularly those with type 2 diabetes. Ferroptosis is closely linked to the onset and progression of various cardiovascular diseases. Irisin, a myokine produced by exercising skeletal muscle, has been shown to mitigate DCM. However, whether irisin alleviates ty...

Schistosomiasis affects more than 230 million people worldwide. Control and elimination of this parasitic infection is based on mass drug administration of praziquantel (PZQ), which has been in use for several decades. Because of the limitations of the efficacy of PZQ especially against juvenile worms, and the threat of the emergence of resistance,...

Traditionally, chemically synthesized metal oxide nanoparticles do not offer an environmentally friendly approach to alleviate abiotic stresses in plants. This study evaluated the potential of microbially-synthesized zinc oxide nanoparticles (ZnO NPs) in mitigating the municipal wastewater stress in wheat crop. ZnO NPs synthesized from Shewanela. s...

Perinatal exposure to nicotine has been implicated in causing significant oxidative stress and long-term neurobehavioral abnormalities. This study explores, for the first time, the efficacy of Anethum graveolens (dill) extract in mitigating neurotoxicity, oxidative damage, inflammation, and behavioral disturbances in neonatal mice exposed to nicoti...

The World Health Organization (WHO) recommends conducting a baseline survey to quantify the infection burden of schistosomiasis and soil transmitted helminths (STH) in pre-school aged children (PSAC) and school-aged children (SAC) before implementing a schistosomiasis mass drug administration intervention. The objective of the study was to compare...

Objective This study aimed to examine the preventive impact of Liuwei Dihuang pill (LWDH) on ovarian injury and to elucidate its mechanism through in vivo and in vitro tests. Methods Cyclophosphamide (CTX) was injected intraperitoneally and LWDH suspension was administered intragastrically to create a mouse model of primary ovarian insufficiency....

Nuclear-propelled vessels (e.g. ships and submarines) are often stationed in the Greek port of Souda.To this end, a hypothetical release from a nuclear-powered submarine was produced and studied, using the decision-support system JRODOS. The study focused on determining the radiological risk to workers of the port. It was found that the internal co...

Tomato (Solanum lycopersicum L.) is a globally strategic crop, vital for food security and agricultural economies, yet its productivity is increasingly threatened by biotic and abiotic stresses. This study investigates the combined effects of Fusarium oxysporum f. sp. lycopersici (FOL), heavy metals (cadmium, cobalt, chromium and lead), and salinit...

Aim: We investigated the effects of prenatal nicotine exposure on selected parameters in first filial (F1) generation female rats. Methods: Twenty-five adult female rats were divided into five groups and mated as follows: Group I, II, and III respectively received 0.2 ml/kg of normal saline, 0.5 and 1.0 mg/kg BW of nicotine daily for 28 days before...

Background: Oxidative stress and trace element imbalance are implicated in the pathogenesis of type 2 diabetes mellitus (T2DM). Zinc serves as an antioxidant and insulin cofactor, whereas dysregulated copper may amplify oxidative damage. This study investigated serum zinc, copper, their ratio (Zn/Cu), and lipid peroxidation markers across glycaemic...

The antioxidant effects of Terminalia catappa ethanol seed extract in the liver and kidneys of diabetic Wistar rats induced with streptozotocin was investigated. Thirty rats weighing 140 g – 180 g were randomly divided into five treatment groups. The normal control (NC) and 50 mg/kg b.w streptozotocin-induced diabetic control (DC) groups received p...

INTRODUCTION The long-term effects of chronic electronic cigarette (e-cigarette) exposure on lung and heart inflammation during the healing phase of myocardial infarction (MI) remain unexplored. Additionally, the impact of e-cigarette exposure on blood parameters in this context is unclear. This study aims to assess e-cigarette with nicotine (e-cig...

Turmeric powder (TP) supplementation is a widely used strategy to enhance hens' productivity and potentially mitigate egg fat oxidation by increasing antioxidant activity. Therefore, this study aimed to investigate the impact of TP supplementation on egg quality, antioxidant activity, and yolk fatty acid profile. A total of 100 56-week-old Novogen...

Excessive production of reactive oxygen species (ROS) in plant tissues capable of cellular damage has been linked to abiotic stress conditions such as drought. However, the role of biochar as a soil amendment in mitigating the impact of oxidative stress has been under-explored. Therefore, this study investigated the role of biochar in mitigating ox...

Tropical regions face climate change, which increases the impacts of heat stress (HS) on ram fertility. Twenty-four Barbados Blackbelly rams were divided into intensive (ITS) and semi-intensive (SIS) management systems. ITS rams were housed in a barn, while SIS rams spent six hours daily outside over two months. Daily climate data were collected, a...

The hypoxic microenvironment is the main challenge for the repair of damaged tissue, and oxygen supply is an effective means of alleviating hypoxia. In this study, a series of core–shell-structured calcium peroxide/poly(ethylene glycol)@silica (CPO@SiO2) nanoparticles are prepared to generate oxygen steadily. The size of the CPO@SiO2 nanoparticles...

Asthma is a chronic inflammatory disorder of the airways, marked by hyperresponsiveness and oxidative stress. Despite advancements in pharmacotherapy, side effects and limited efficacy drive the search for botanical alternatives. This study investigates the immunomodulatory and antioxidant properties of aqueous extracts of Euphorbia hirta and Lactu...

This study seeks to establish a rapid, non-invasive methodology for the detection of drug abuse through the identification of common urinary drug metabolites utilizing attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). ATR-FTIR spectroscopy was employed to detect and differentiate metabolites of heroin (6-AM), ecstasy...

Radiation exposure causes neuroinflammation, oxidative stress, and neuronal loss, leading to cognitive and behavioral impairments. This study aims to evaluate the effect of niacin interventions on whole-brain irradiation (WBI)-induced cognitive and behavioral impairment. Female Wistar rats were randomly assigned to Control (Group 1), Radiation +Sal...

Allium tuberosum (Chinese chives; CC) contains large amounts of metabolites that have antibacterial, antioxidant, and anti-inflammatory properties. In our previous study, fermented CC was shown to improve physiological functions and have positive results in broilers. In this study, we investigated egg productivity, egg quality, blood parameters, or...

Drought is one of the main environmental disturbances limiting the growth and production of turfgrass in China and around the world. To study the performance under drought conditions of different mixing ratios (Lolium perenne L., Festuca elata Keng., Poa pratensis L.), a water-controlled pot experiment was conducted. The mixing ratios used were 2:3...

Hypertension is a prevalent condition that contributes significantly to the global disease burden. Recent research endeavors have been investigating the potential causal link between metal exposure and the development of hypertension, yet consensus remains elusive. Nevertheless, studies examining the interplay among metal exposure, hypertension, an...

Nuclear - contaminated water, a concerning byproduct of nuclear mishaps and industrial operations, contains radioactive elements. These substances pose substantial threats to both human health and the environment. Since the release of processed water contaminated with nuclear substances into the Pacific Ocean in 2023, global concerns have been moun...

Back ground Phoenix dactylifera L. seeds, the primary byproducts of date consumption, are recognised for their intriguing pharmacological potential. Methods This research aimed to investigate the metabolite profile of three Egyptian date seeds (Ajwa, Zaghloul, and Sukkari) using hydroalcoholic extracts and determine their antidiabetic activity thr...

Although ginsenoside RK1 (RK1) possesses neuroprotective properties, it is unknown how it relates to vascular dementia (VD). The purpose of this work was to show that RK1 has a neuroprotective function in VD. First, the VD rat model was established by ligating the carotid artery with two-vessel occlusion (2-VO) surgery. RK1 was given daily for 30 d...