Science topic

Lymphatic System - Science topic

A system of organs and tissues that process and transport immune cells and LYMPH.
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Publications related to Lymphatic System (8,187)
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Tuberculosis (TB) primarily affects the lungs, but some of its most devastating clinical consequences arise because of its ability to spread from the lungs to other organs. Extrapulmonary TB (EPTB) constitutes 15–20% of all TB cases. Imaging findings are not always specific and can mimic many diseases; therefore, EPTB should be considered in the di...
Article
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Machine learning methods have been an interesting method in the field of medical for many years, and they have achieved successful results in various fields of medical science. This paper examines the effects of using machine learning algorithms in the diagnosis and classification of breast cancer from mammography imaging data. Cancer diagnosis is...
Article
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Introduction: Lymphoedema associated with breast cancer is caused by an interruption of the lymphatic system, together with factors such as total mastectomy, axillary dissection, positive lymph nodes, radiotherapy, use of taxanes and obesity. Physiotherapy treatment consists of complex decongestive therapy, manual lymphatic drainage and exercises,...
Article
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Chyle leak/fistula is a rare complication of oesophageal cancer surgery, usually consequent on an unintended breach of the thoracic duct, its tributaries or the cisterna chyli. For high volume persistent leaks, further surgery, either open or minimally invasive trans-thoracic, with a potentially significant risk of attendant morbidity. At this Nati...
Article
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Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA development. To better understand the pathologica...
Article
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Background Seaweed polysaccharides have been recommended as anticancer supplements and for boosting human health; however, their benefits in the treatment of triple-negative breast cancers (TNBCs) and improving immune surveillance remain unclear. Olaparib is a first-in-class poly (ADP-ribose) polymerase inhibitor. Oligo-Fucoidan, a low-molecular-we...
Preprint
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Background Chyluria is defined as the presence of chyle in the urine that is caused by chylous reflux through the communication between the lymphatic system and the urinary tract. Thoracic duct stenosis or obstruction is one of the causes of chyluria. Although the diagnosis of chyluria is not difficult, treatment is still challenging. Although ther...
Article
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Clearance of ocular fluid and metabolic waste is a critical function of the eye in health and disease. The eye has distinct fluid outflow pathways in both the anterior and posterior segments. Although the anterior outflow pathway is well characterized, little is known about posterior outflow routes. Recent studies suggest that lymphatic and glympha...
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Do lymphatic vessels support cancer cells? Or are they vessels that help suppress cancer development? It is known that the lymphatic system is a vehicle for tumor metastasis and that the lymphangiogenic regulator VEGF-C supports the tumor. One such role of VEGF-C is the suppression of the immune response to cancer. The lymphatic system has also bee...
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Subarachnoid hemorrhage (SAH) is an important public health concern with high morbidity and mortality worldwide. SAH induces cell death, blood−brain barrier (BBB) damage, brain edema and oxidative stress. As the most abundant cell type in the central nervous system, astrocytes play an essential role in brain damage and recovery following SAH. This...
Article
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The ecosystem of the human gastrointestinal tract, named gut microbiota, represents the most thoroughly mapped ecosystem. Perturbations on bacterial populations cause dysbiosis, a condition correlated to a wide range of autoimmune, neurological, metabolic, cardiovascular, and respiratory diseases. The lungs have their flora, which are directly rela...
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We are reporting a case of a 27-year-old young female who presented with right side neck swelling without any associated obstructive symptoms and any other grave signs and symptoms. She noticed a gradual increase in the size of the swelling within a period of 2 years. After investigation and surgical excision, the swelling was diagnosed as cystic h...
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We present comprehensive mathematical modeling of radiopharmaceutical spatiotemporal distributions within vascularized solid tumors. The novelty of the presented model is at mathematical level. From the mathematical viewpoint, we provide a general modeling framework for the process of radiopharmaceutical distribution in the tumor microenvironment t...
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Although metastatic melanoma can be managed with chemotherapy, its heterogeneity and resistance to therapy remain poorly understood. In addition to the spread of melanoma in the bloodstream, melanoma‐stroma interaction and the lymphatic system play active roles in said heterogeneity and resistance, leading to its progression and metastasis. Reprodu...
Article
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The Fontan operation is a palliative procedure that leads to increased survival of patients with a functional single ventricle (SV). Starting from 1967 when the first operation was performed by Francis Fontan, more and more patients have reached adulthood. Furthermore, it is expected that in the next 20 years, the population with Fontan circulation...
Preprint
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PURPOSE Lymph node involvement in cervical cancer is a major independent prognostic factor for overall survival. The aim of our study was to examine the lymphatic drainage regions of the different parts of the cervix by an anatomical and radio-anatomical study. METHODS An anatomical study of fresh cadavers was conducted by injecting patent blue in...
Article
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Background: The modern concept of lymphatic transfer includes vascularised lymph node transfer (VLNT), lymphatic vessels transfer (lymph interpositional flap transfer, LIFT) and lymphatic system transfer (vascularised lymph nodes and afferent lymphatics, LYST). The aim of this paper was to report our experience with different types of lymphatic tr...
Article
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Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lymphocyte migration from the vasculature into the lymph nodes and Peyer's patches. We have identified that DACH1...
Article
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Amyloid-β (Aβ) deposition plays a crucial role in the occurrence and development of Alzheimer’s disease (AD), and impaired Aβ clearance is the leading cause of Aβ deposition. Recently, studies have found that the glymphatic system performs similar functions to the peripheral lymphatic system. Glymphatic fluid transport mainly consists of cerebrospi...
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The lymphatic system has been poorly understood and its importance neglected for decades. Growing understanding of lymphatic flow pathophysiology through peripheral and central lymphatic flow imaging has improved diagnosis and treatment options in children with lymphatic diseases. Flow dynamics can now be visualized by different means including dyn...
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Major depressive disorder is one of the most common mental health conditions. Meningeal lymphatics are essential for drainage of molecules in the cerebrospinal fluid to the peripheral immune system. Their potential role in depression-like behaviour has not been investigated. Here, we show in mice, sub-chronic variable stress as a model of depressio...
Article
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Background: In recent years, the attention of the scientific world has focused on a clearance system of brain waste metabolites, called the glymphatic system, based on its similarity to the lymphatic system in peripheral tissue and the relevant role of the AQP4 glial channels and described for the first time in 2012. Consequently, numerous studies...
Article
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The lymphatic system plays a crucial role in mounting immune response against intracellular pathogens, and recent studies have documented its role in facilitating tumor dissemination linked largely with cancer cells. However, in mucocutaneous leishmaniasis (MCL) caused by Leishmania Viannia subgenus showing infectious metastasis and resulting in se...
Article
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Turner’s syndrome is one of the most frequently reported sex chromosomal abnormalities, affecting approximately 40 in every 100,000 live female births. The underlying chromosomal alteration is the complete or partial loss of X-chromosome or mosaicism. Due to primary ovarian insufficiency, the synthesis of estrogen hormones is compromised, and patie...
Article
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Lymphedema is a progressive disease caused by lymphatic flow blockage in the lymphatic pathway. Primary (hereditary) lymphedema is caused by genetic mutations without secondary causes. We performed clinical profiling on Korean primary lymphedema patients based on their phenotypes using lymphoscintigraphy and made genetic diagnoses using a next-gene...
Presentation
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Each Video has a citable DOI. Click the top line research tab and then the individual videos to access the DOIs ._______ These videos adds to evidence that the aqueous outflow system functions as a pump-conduit system to regulate aqueous outflow by mechanisms like those in the cardiovascular and lymphatic systems. ___Clinical evidence includes dire...
Article
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Light is a natural agent consisting of a range of visible and invisible electromagnetic spectrum travels in waves. Near-infrared (NIR) light refers to wavelengths from 800 to 2,500 nm. It is an invisible spectrum to naked eyes and can penetrate through soft and hard tissues into deep structures of the human body at specific wavelengths. NIR light m...
Article
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Pulmonary lymphangitic carcinomatosis is the spread of malignant cells to the lymphatic system in the lungs, which results in inflammation and lymphatic dilation. It is often found to coexist in patients with prior history of malignancy. The clinical presentation is usually related to respiratory symptoms, but atypical presentation can occur. Chest...
Article
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The tumour microenvironment (TME) comprises a complex ecosystem of different cell types, including immune cells, cells of the vasculature and lymphatic system, cancer-associated fibroblasts, pericytes, and adipocytes. Cancer proliferation, invasion, metastasis, drug resistance and immune escape are all influenced by the dynamic interaction between...
Conference Paper
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text: Background: Immunotherapy has taken a worthy place in the existing protocols for beating cancer. Real achievements and effectiveness in this area are striking, nevertheless, there are problems that make us look for alternative solutions. The positively proven technology of bone marrow transplantation has disadvantages-poor survival, graft-ver...
Conference Paper
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text: Background and context: The narrow specialization of medical structures is not always rational. Current times dictate to integrate innovative, personalized protocols into robust, proven medical systems. Aim: Creation of an innovative anti-cancer platform (IAP), which includes specialized systems for early diagnosis, cognitive anti-stress meth...
Presentation
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This video adds to evidence that the aqueous outflow system functions as a pump-conduit system to regulate aqueous outflow by mechanisms like those in the cardiovascular and lymphatic systems. ___Clinical evidence includes direct observation of pulsatile flow into SC, collector channels, and aqueous veins.___Laboratory evidence includes pressure-de...
Presentation
Full-text available
This video adds to evidence that the aqueous outflow system functions as a pump-conduit system to regulate aqueous outflow by mechanisms like those in the cardiovascular and lymphatic systems. ___Clinical evidence includes direct observation of pulsatile flow into SC, collector channels, and aqueous veins.___Laboratory evidence includes pressure-de...
Presentation
Full-text available
This video adds to evidence that the aqueous outflow system functions as a pump-conduit system to regulate aqueous outflow by mechanisms like those in the cardiovascular and lymphatic systems. ___Clinical evidence includes direct observation of pulsatile flow into SC, collector channels, and aqueous veins.___Laboratory evidence includes pressure-de...
Presentation
Full-text available
This video adds to evidence that the aqueous outflow system functions as a pump-conduit system to regulate aqueous outflow by mechanisms like those in the cardiovascular and lymphatic systems. ___Clinical evidence includes direct observation of pulsatile flow into SC, collector channels, and aqueous veins.___Laboratory evidence includes pressure-de...
Presentation
Full-text available
This video adds to evidence that the aqueous outflow system functions as a pump-conduit system to regulate aqueous outflow by mechanisms like those in the cardiovascular and lymphatic systems. ___Clinical evidence includes direct observation of pulsatile flow into SC, collector channels, and aqueous veins.___Laboratory evidence includes pressure-de...
Presentation
Full-text available
This video adds to evidence that the aqueous outflow system functions as a pump-conduit system to regulate aqueous outflow by mechanisms like those in the cardiovascular and lymphatic systems. ___Clinical evidence includes direct observation of pulsatile flow into SC, collector channels, and aqueous veins.___Laboratory evidence includes pressure-de...
Article
Full-text available
Lymphatic endothelial cell homeostasis plays important roles in normal physiological cardiac functions, and its dysfunction significantly influences pathological cardiac remodeling after myocardial infarction (MI). Our results revealed that sphingosine 1-phosphate receptor 1 (S1pr1) expression in cardiac lymphatic endothelial cells (LECs) was sharp...
Article
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Chronic Progressive Lymphoedema (CPL) is a disabling disease of draft horses that affects lymphatic system function typically in the distal limbs. Deformities of distal limbs, especially of the pastern, with fibrosis and skin nodular lesions are consequences of disease progression. A 15-year-old Friesian stallion presented for evaluation with histo...
Article
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Congestion is the single most important contributor to heart failure (HF) decompensation. Most of the excess volume in patients with HF resides in the interstitial compartment. Inadequate decongestion implies persistent interstitial congestion and is associated with worse outcomes. Therefore, effective interstitial decongestion represents an unmet...
Article
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Introduction The lower limbs are a common body site affected by chronic edema. Imaging examination of the lymphatic system is useful to diagnose lymphoedema, identify structural changes in individuals and guide interventional strategies. In this study, we used a protocol combining indocyanine green (ICG) lymphography and ICG guided manual lymphatic...
Presentation
Full-text available
This video adds to evidence that the aqueous outflow system functions as a pump-conduit system to regulate aqueous outflow by mechanisms like those in the cardiovascular and lymphatic systems. ___Clinical evidence includes direct observation of pulsatile flow into SC, collector channels, and aqueous veins.___Laboratory evidence includes pressure-de...
Presentation
Full-text available
This video adds to evidence that the aqueous outflow system functions as a pump-conduit system to regulate aqueous outflow by mechanisms like those in the cardiovascular and lymphatic systems. ___Clinical evidence includes direct observation of pulsatile flow into SC, collector channels, and aqueous veins.___Laboratory evidence includes pressure-de...
Article
Full-text available
Approval of B-cell-depleting therapies signifies an important advance in the treatment of multiple sclerosis (MS). However, it is unclear whether the administration route of anti-CD20 monoclonal antibodies (mAbs) alters tissue distribution patterns and subsequent downstream effects. This study aimed to investigate the distribution and efficacy of r...
Article
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Efficient transport of solutes in the cerebrospinal fluid (CSF) plays a critical role in their clearance from the brain. Convective bulk flow of solutes in the CSF in the perivascular space (PVS) is considered one of the important mechanisms behind solute movement in the brain, before their ultimate drainage to the systemic lymphatic system. Acoust...
Presentation
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Rustarangani ath yasad shlok no 120 to 123 It increases the body strength and resistance Rustantrasar va sidhprayogsangreh-chapter yasad bhasm, Rustantradsar va sidhprayogsangreh-chapter yasad-Zinc is essential for nucleic acid metabolism and protein synthesis .it plays role in collagen formation, glycol sis, and oxidative phosphorisation. For main...
Article
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Infection, trauma, cancer, or abdominal surgery can all induce chylous ascites. Chylous ascites (CA) following liver transplantation is extremely rare. The case we present here is of a patient who developed chylous ascites after a liver transplant and was treated with a combination of modalities before being resolved by lipiodol embolization of a l...
Preprint
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Introduction: Diseases associated with the Central Nervous System (CNS) represent a group of conditions with important social and economic repercussions. New treatment strategies with NeuroEPO offer new opportunities to prevent the onset and progression of these disorders. NeuroEPO administered intranasally can reach the CNS through various mechani...
Article
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Retroperitoneal masses are a rare condition that may be discovered incidentally in routine abdominal imaging. These lesions are commonly asymptomatic but may be associated with intestinal obstruction and rarely presented with acute abdomen. They may originate from the retroperitoneal organs, including the genitourinary or gastrointestinal tract, or...
Article
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Congenital heart disease can lead to various lymphatic complications including traumatic leaks, lymphatic overproduction, conduction abnormalities or lymphedema. Advancements in the imaging of central lymphatics and guided interventions have improved outcomes in these children. Dynamic contrast-enhanced magnetic resonance (MR) lymphangiography allo...
Article
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This brief report demonstrates the diagnostic utility of cone-beam CT lymphangiography (CBCTL) with intranodal injection of water-soluble iodinated contrast agent for assessing lymphatic disorders in two infants who were contraindicated for MRI and oil-based contrast agent. Both infants had dextro-transposition of the great arteries (d-TGA) and pre...
Article
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Lymphaticovenous malformations (LVMs) are a rare subset of congenital vascular malformations that result from the defective development of the vascular and lymphatic systems during embryogenesis. LVMs can cause pathological mass effects or lead to thrombotic complications. We present a rare case of the surgical management of bilateral LVMs arising...
Article
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The human PROX1 gene (Prospero homeobox gene 1) is a member of the homeobox transcription factor family. PROX1 plays a key role in the development of the lymphatic system and is primarily used as a lymphatic vessel marker. However, as the accumulating evidence indicates that PROX1 is also implicated in the tumorigenesis of various cancer types, the...
Article
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Lymphedema is a chronic inflammatory disorder caused by ineffective fluid uptake by the lymphatic system, with effects mainly on the lower limbs. Lymphedema is either primary, when caused by genetic mutations, or secondary, when it follows injury, infection, or surgery. In this study, we aim to assess to what extent the current genetic tests detect...
Article
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Introduction Lymphangioma is a malformation of the lymphatic system. It is a rare occurrence in adults. The exact etiology of the disease is unclear but it is expected to be either congenital or due to obstruction and retention of lymph in developing lymphatic vessels. Case Description We report a case of Parotid Lymphangioma in a 35-year-old male...
Article
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Meningeal lymphatic vessels (MLVs) were identified in the dorsal and caudobasal regions of the dura mater, where they ensure waste product elimination and immune surveillance of brain tissues. Whether MLVs exist in the anterior part of the murine and human skull and how they connect with the glymphatic system and extracranial lymphatics remained un...
Article
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Background Lymphangioleiomyomatosis (LAM) is a rare low-grade metastatic tumor with an unknown origin that spreads through lymphatic vessels. It is characterized by the proliferation of smooth muscle-like or epithelioid tumor cells in the lung and axial lymphatic system. Extrapulmonary LAM is a localized disease with a low incidence rate, and the l...
Article
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The lymphatic system continues to gain importance in a range of conditions, and therefore, imaging of lymphatic vessels is becoming more widespread for research, diagnosis, and treatment. Fluorescent lymphatic imaging offers advantages over other methods in that it is affordable, has higher resolution, and does not require radiation exposure. Howev...
Article
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Purpose: The present study aimed to develop gefitinib-loaded solid lipid nanoparticles (GEF-SLN), and GEF-loaded PEGylated SLN (GEF-P-SLN) for targeting metastatic lung cancer through the lymphatic system. Methods: The prepared SLNs were characterized in terms of physicochemical properties, entrapment efficiency, and in-vitro release. Furthermore,...
Article
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Hong Duc Pham,1,2 The Anh Nguyen,3 Thi Giang Doan,1,2 Van Giang Bui,2,4 Thanh Van Phan-Nguyen5 1Radiology Department, Saint Paul Hospital of Ha Noi, Ha Noi, Vietnam; 2Radiology Department, Hanoi Medical University, Ha Noi, Vietnam; 3Department of Respiratory Medicine, Huu Nghi Hospital, Hanoi, Vietnam; 4Radiology Centre, National Cancer Hospital, H...