Local Anesthetics - Science topic
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
Questions related to Local Anesthetics
The antimicrobial effect of local anesthetics has been known for more than 50 years, but it still seems to have an unclear mechanism of action. which bacteria? which concentration? etc etc. . Where can I find more literature?
I have observed not much difference in the onset of action of different local anesthetics ( bupivacaine, lignocaine and ropivacaine) when used for peripheral nerve /plexus blocks. Although studies are warranted for proof, it is just my observation. Please share your views and experiences
Dear researchers, what do you think about the idea of an inhalation therapy with Procain 1% or Lidocain 1% as an adjuvant therapy of viral pneumonia caused by SARS-CoV-2 in order to prevent ARDS?
Two very interesting links discussing the anti-inflammatory properties of local anesthetics:
page 270, Cytokines
I am trying to develop a simple Organic Chemistry Lab that will teach students on how to conduct Esterification reaction. The catch is that the synthesized molecule should have recognized medicinal value.
I want to synthesize Procaine as it is a widely known as a local anesthetic. However, the lab doesn't have 2-diethylaminoethanol. So, is it possible to do it from Triethanolamine instead?
When Stanley Malamed, in his books and many of his papers, writes that " IANB has the highest failure rate among all local anesthetic blocks in Medicine - not only in dental local anesthesia : are there any data in the medical literature backing this assertion, or do you think it is simply a fact that he personnaly observed or experienced as a dentist-anesthesiologist, without scientific evidence ? In the first case, are there references readily availa and if so, could anybody let me know how and where I can get it ?
Thank you for your comments.
Local anesthetics produce anesthesia by inhibiting excitation of nerve endings or by blocking conduction in peripheral nerves.
1. Epinephrine may cause acute hypertensive crisis (dangerously high blood pressure)
2. Interaction of epinephrine and some antihypertensive medications may cause acute hypertensive or hypotensive crisis.
the drug is tested and is safe to use. It is used clinically for different purposes. However, it has some local anesthetic properties which we would like to test clinically. is there any known protocol that is used in such type of research?
please advise. Thanks
Is there any well documented study(ies) supporting the statement by John Meechan in his book “Practical dental anesthesia” that epinephrine added to dental local anesthetic formulations modifies the distribution of blood in the body and sends relatively more to the brain, so that epinephrine might increase the toxicity of local anesthetic molecules on the Central Nervous System ?
As in the majority of the hospitals, we use a blood management program. We use postsurgery blood recovery system in some situations: low presurgery Hb level, tranexamic acid contraindication..., but, if the surgeon practices an intraarticular infiltration of local anesthetic, within a fast recovery system, we won't be able to use it, . What is more important in your opinion, faster recovery or lower possibility of blood transfusion?
There are some patients have a resistance to local anesthesia .Although a proper injection techinque is performed ,those patients cant anaesthetized.
Are there certain drugs or a milk of camal female makes you resistant to local ansthesia?
Most local anaesthetics are weak bases, with a pKa between 8 and 9, so that they are mainly but not completely ionised at physiological pH.your comments
A nerve block is a treatment used to both treat and diagnose severe pain. We often use local anesthetic like lidocaine for exemple.
Have you some references about peripheral nerve blocks wtih alcohol for chronic pain?
what is the effect of local anesthesia on the respiratory, cardiovascular system in pregnancy women ? and what about the fetus safety?
I researched a lot for this topic and I cannot find satisfied articles and information
Dear Dr. Piccini and colleagues,
Many thanks for sending e a full text version of Paraesthesia after Local Anaesthetics: An Analysis of Reports to the FDA Adverse Event Reporting System. It is a very important work.
You may be interested in my continued research subsequent to my 2006 paper that you kindly referred in your article.
If you send me your e mail address, I would be more than happy to send you my recent works, a combined clinical- and registry study, and an animal experiment.
Søren Hillerup, PhD, Dr Odont.
Professor em., Maxillofacial Surgery
RV or LV Catheterization Protocol for Swine (50-70 kg) Yorkshire recovery procedure.
Based on your best results, what is the most up to date protocol (published or internal) for using Amiodarone in combination with Lidocaine. Please post, if possible your insights or experience with using both drugs in swine post-LV or RV cath recovery.
What is the best dose regiment for i.v. for Amiodarone (alone or in combo with Lido)? Also is per os (2-3 days before catetherization) better than i.v. dosing and why for recovery procedures?
Dexmedetomidine is used as an adjuvant to intrathecal local anesthetic (Bupivacaine/ Ropivacaine ). Does it help in prolonging duration of spinal anesthesia? How would you rate it on comparison to fentanyl/ morphine?
We have done test doses so far, but not a single person had a reaction. And it is time wasting to wait and do the procedure. Are there any recommendations.
Position plays a vital role in subarachnoid blockade specially while using hyperbaric local anesthetic agents. Sitting or supine position may affect the final height of the block. Is there any modification of positioning while using isobaric local anesthetic agents?
I'm looking for a review about percentages and statistical data about which are the most commonly used anesthetic.