Liver Diseases - Science topic

Transplantation of the left lateral section (LLS) of the liver is now an established practice for treating advanced diffuse and unresectable focal liver diseases in children, with variants of the LLS primarily used in infants. However, the surgical challenge of matching the size of an adult donor's graft to the volume of a child's abdomen remains s...

BACKGROUND Chronic liver disease is a growing global health problem, leading to hepatic decompensation characterized by an array of clinical and biochemical complications. Several scoring systems have been introduced in assessing the severity of hepatic decompensation with the most frequent ones are Child-Pugh score, model

Objectives: To explore the correlation between serum Golgi protein 73 (GP73) levels and the degree of fibrosis in Metabolic dysfunction associated steatotic liver disease (MASLD); to establish a non-invasive diagnostic algorithm based on serum GP73 and liver elasticity. Methods: This is a prospective cross-sectional study, including 228 patients di...

Background Triglyceride-glucose (TyG) related indices, which serve as simple markers for insulin resistance, have been closely linked to metabolic dysfunction-associated steatotic liver disease (MASLD), cardiovascular disease (CVD), and mortality. However, the prognostic utility of TyG-related indices in predicting the risk of CVD and mortality amo...

Purpose of Review In recent years, the terms “metabolic associated fatty liver disease-MAFLD” and “metabolic dysfunction-associated steatotic liver disease-MASLD” were introduced to improve the encapsulation of metabolic dysregulation in this patient population, as well as to avoid the negative/stigmatizing terms “non-alcoholic” and “fatty”. Recen...

Objectives This study aims to investigate the impact of comorbidity with chronic hepatitis B (CHB) on the survival rates and incidence of liver cancer in patients with alcohol‐related liver disease (ARLD). Methods Patients with ARLD and those with ARLD co‐morbid with CHB were included in this study and designated as the ARLD group and the ARLD + H...

Our study investigated the prevalence of lean steatotic liver disease (SLD) and its subcategories, including metabolic dysfunction‐associated steatotic liver disease (MASLD), metabolic dysfunction‐related and alcohol‐related SLD (MetALD), and alcohol‐related liver disease (ALD) among lean adults in the US. Analysing data from 2965 lean adults (≥ 18...

This study aimed to describe the profile and calculate the years of potential life lost (YPLL) due to liver diseases in Brazilian agricultural workers from 2017 to 2022. For this, we analyzed microdata available in the Brazilian Mortality Information System considering the underlying cause of death with codes K70-K77 (International Classification o...

To assess the diagnostic accuracy of two-dimensional shear wave elastography (2-D SWE) and point shear wave elastography (pSWE) in detecting liver fibrosis stages in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), a comprehensive search was conducted across four databases up to February 9, 2024. A bivariate random-ef...

Background and Aims Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) and sodium‐glucose cotransporter‐2 inhibitors (SGLT2is) have demonstrated long‐term liver benefits in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD) and type 2 diabetes (T2D). However, no direct comparison between these therapies has been condu...

Metabolic dysfunction associated steatotic liver disease (MASLD) has been associated with increased risks of all-cause and cardiovascular disease (CVD) mortality. Identification of modifiable risk factors that may contribute to higher risks of mortality could facilitate targeted and intensive intervention strategies in this population. This study a...

Metabolic dysfunction-associated steatotic liver disease (MASLD) is an emerging global health concern, and it is not only the keystone precursor of eventual liver-related morbidity, but it also places patients at considerably higher cardiovascular risk, which is still a leading cause of death in these patients. The most important common underlying...

Adult growth hormone deficiency (AGHD) is often accompanied with metabolic dysfunction-associated steatotic liver disease (MASLD). Although some studies reported that MASLD is ameliorated by growth hormone replacement therapy (GHRT), the characteristics of AGHD that are associated with an improvement of hepatic steatosis by GHRT remain unknown. We...

Background Formerly known as non-alcoholic fatty liver disease (NAFLD), metabolic dysfunction-associated steatotic liver disease (MASLD) has now become the most widespread chronic liver disease worldwide. The primary goal of this study is to assess the ability of different indexes (including VAI, TyG, HOMA-IR, BMI, LAP, WHtR, TyG-BMI, TyG-WC, and T...

Identifying dependable prognostic indicators is essential for the efficient management of metabolic dysfunction-associated steatotic liver disease (MASLD). The index of hemoglobin glycation (HGI) has been demonstrated to be closely linked to the onset and advancement of MASLD. Currently, no studies have investigated the relationship between HGI and...

Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease worldwide, with no universally recognized effective treatments currently available. In recent years, ginseng and its principal active components, such as ginsenosides, have shown potential protective effects in the treatment of these liver diseases. In NAFLD, stud...

Objective This study aims to evaluate the current state of family function and self-management abilities in patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and analyze the correlation between the two. Methods Baseline data were collected from 243 patients with MASLD, utilizing the Family Care Index and Self-Managemen...

T1 relaxation time quantification on parametric maps is routinely used in cardiac imaging and may serve as a non-invasive biomarker for diffuse liver disease. In this study, we aimed to investigate the relationship between liver T1 values and cardiac function in patients with congenital heart disease (CHD) and compared patients with a biventricular...

Background and Aims Metabolic dysfunction-associated steatotic liver disease (MASLD) has a global prevalence of 25%. Studies on incident liver and cardiovascular outcomes in lean (Body mass index: BMI < 25 kg/m², or < 23 kg/m² for Asians) vs. non-lean individuals with MASLD have reported mixed results. We aimed to compare incident clinical outcomes...

Liver diseases pose a significant global health challenge, affecting millions of individuals and resulting in substantial morbidity and mortality [...]

Cardiovascular–Kidney–Metabolic syndrome, introduced by the American Heart Association in 2023, represents a complex and interconnected spectrum of diseases driven by shared pathophysiological mechanisms. However, this framework notably excludes the liver—an organ fundamental to metabolic regulation. Building on this concept, Cardiovascular–Renal–H...

Background: Celiac Disease (CD) is known as a gluten enteropathy, it is a disease that affects many organs, and findings outside the gastrointestinal tract are common. CD-associated liver disease is probably developed by variable factors, comprising intestinal bacterial overgrowth, chronic infection and inflammation, gut permeability, genetic, mole...

Purpose The prevalence of obesity, along with that of its associated health conditions, including cardiovascular diseases, diabetes mellitus, and liver diseases, such as non-alcoholic fatty liver disease (NAFLD), is increasing annually. Bariatric surgery is indicated for the treatment of obesity if conservative treatment fails. While various liver...

Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disease in the world and a growing cause of liver-related morbidity and mortality. Yet, at the same time, our understanding of the pathophysiology and genetic underpinnings of this increasingly common yet heterogeneous disease has increased dramaticall...

Background Gestational alloimmune liver disease (GALD) is characterized by maternal IgG-directed fetal hepatocyte damage and can lead to severe liver failure and fetal or infant death. Moreover, GALD is associated with a near 90% risk of recurrence in subsequent pregnancies. Case We present a case of a newborn patient delivered to a 32-year-old G2P...

The progression of fatty liver disease to hepatocellular carcinoma (HCC) is a multifaceted process involving metabolic, genetic, and environmental factors. This paper reviews the pathophysiology, risk factors, and stages of disease progression, emphasizing the transition from non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatit...

There is a complex interplay between the gut microbes, liver, and central nervous system, a gut-liver-brain axis, where the brain impacts intestinal and hepatic function while the gut and liver can impact cognition and mental status. Dysregulation of this axis can be seen in numerous diseases. Hepatic encephalopathy, a consequence of cirrhosis, is...

Background The myriad implications of heavy metal pollution on human health have garnered substantial attention within the academic domain. Nevertheless, a notable research gap persists, as there is currently insufficient direct investigation elucidating the intricate interplay between nickel exposure and the risk of metabolic dysfunction-associate...

Introduction Grafts with alcohol-associated liver disease (ALD) subjected to prolonged cold ischaemia from donors after brain death (DBD) are typically unsuitable for transplantation. Here, we investigated the role of growth hormone (GH) in livers with ALD from DBDs and its relationship with vascular endothelial growth factor A (VEGFA) and VEGFB....

Objective: This is a systematic review and meta-analysis that aims to evaluate the prevalence of non-alcoholic fatty liver disease (NAFLD) and the risk factors such as type 2 diabetes mellitus (T2DM), hypertension, obesity, PCOS, and sleep apnea associated with it. NAFLD is one of the most prevalent diseases that affect approximately 40% of diabeti...

Background Psoriasis requires a comprehensive assessment of concomitant diseases to make better therapeutic decisions. This study examined the differences in the onset and progression of associated cardiometabolic comorbidities in psoriasis patients based on their treatments. Methods A retrospective longitudinal study was conducted on patients age...

Background US tools to quantify hepatic steatosis have recently been made clinically available by different manufacturers, but comparative data on their consistency are lacking. Objective US tools to quantify hepatic steatosis have recently been made clinically available by different manufacturers, but comparative data on their consistency are lac...

In the article discusses and illustrates a case of diagnosing successfully treated venoocclusive liver disease in a child with neuroblastoma after autologous stem cell transplantation. The clinical characteristics of veno-occlusive liver disease and the multimodal ultrasound examination procedure, which determines the priority diagnostic capabiliti...

Histopathologic evaluation of liver biopsy has played a longstanding role in the diagnosis and management of liver disease. However, the utility of liver biopsy has been questioned by some, given the improved imaging modalities, increased availability of noninvasive serologic tests, and development of artificial intelligence over the past several y...

Background: Evidence regarding the individual and combined impact of dietary flavonoids on the risk of metabolic dysfunction associated with steatotic liver disease (MASLD) remains scarce. Our objective is to evaluate the association between individual and multiple dietary flavonoids with MASLD in adults. Methods: Data sets were obtained from the N...

Citation: Ganesan, M.; Pathania, A.S.; Bybee, G.; Kharbanda, K.K.; Poluektova, L.Y.; Osna, N.A. Ethanol Disrupts the Protective Crosstalk Between Macrophages and HBV-Infected Hepatocytes. Biomolecules 2025, 15, 57. https:// Abstract: About 296 million people worldwide are living with chronic hepatitis B viral (HBV) infection, and outcomes to end-st...

Objective The study aimed to observe the quantity of platelet aggregation in the hepatic tissue of patients with metabolic-associated fatty liver disease (MAFLD) and its relationship with hepatic inflammation, fibrosis, and fatty degeneration. Methods Clinical data of 55 patients with MAFLD and 25 patients without MAFLD, admitted to the Shenzhen H...

The novel diagnostic term Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) requires at least one cardiovascular risk factor for diagnosis. While the relationship between gallstones and Non-Alcoholic Fatty Liver Disease (NAFLD) has been debated, the association between MASLD and gallstones remains unclear. This cross-sectional study...

Alcohol-related cirrhosis (AC) is a condition that impacts in immunity. We analyzed changes over time in CD4⁺subsets in AC-patients. We included patients with alcohol use disorder admitted at least twice for treatment. Patients without evidence of liver disease were the control group (CG). We analyzed naïve, memory, TEMRA, Th1, Th2, Th17, early act...

Background/Objectives: Obesity and type 2 diabetes (T2D) are associated with significant alterations in various metabolic biomarkers. Isthmin-1 (Ism1) has recently emerged as a potential marker of metabolic health and was shown in animal studies to associate with metabolic-associated fatty liver disease (MAFLD). In this study, we aimed to investiga...

A hepatite autoimune (HAI) é uma doença hepática crônica que predominantemente afeta mulheres, caracterizada por hipergamaglobulinemia, positividade para autoanticorpos, e alterações histológicas no fígado. Sem tratamento, pode evoluir para cirrose e insuficiência hepática. A síndrome inflamatória de reconstituição imune (SIRI), que ocorre após o i...

Chronic liver disease (CLD) is a major global health issue, often progressing silently until it reaches advanced stages, leading to severe illness and death if not detected early. The liver plays a critical role in filtering toxins and aiding digestion , so any disruption can have serious consequences. Raising awareness about liver health is crucia...

The neutrophil-to-lymphocyte ratio (NLR) may predict outcomes in end-stage liver disease, but its value after transjugular intrahepatic portosystemic shunt (TIPS) is unclear. This study explored the link between NLR and long-term outcomes in decompensated cirrhosis patients post-TIPS. We retrospectively analyzed 184 patients treated between January...

Background Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide. The pan-immune-inflammation value (PIV) has been proposed as a biomarker for assessing immune status and inflammation. There is currently no evidence regarding the effect of PIV on the risk of MASLD. This study aim...

About 296 million people worldwide are living with chronic hepatitis B viral (HBV) infection, and outcomes to end-stage liver diseases are potentiated by alcohol. HBV replicates in hepatocytes, but other liver non-parenchymal cells can sense the virus. In this study, we aimed to investigate the regulatory effects of macrophages on HBV marker and in...

Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) and its more severe subtype, metabolic dysfunction‐associated steatohepatitis (MASH), are highly prevalent and strongly associated with obesity and type 2 diabetes (T2D). This study sought to identify challenges to the diagnosis, treatment and management of people...

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a major cause of liver-related morbidity and mortality, contributing to both cardiovascular and non-cardiovascular deaths. The Body Roundness Index (BRI) and Systemic Immune-Inflammation Index (SII) have emerged as predictors of adverse outcomes in metabolic diseases. This study invest...

Liver diseases, particularly metabolic dysfunction-associated steatotic liver disease (MASLD), have emerged as a major global health concern, affecting millions of individuals and leading to increased morbidity and mortality [...]

This study aimed to investigate the correlation and predictive value of TyG and related parameters with metabolic dysfunction-associated fatty liver disease (MAFLD) MAFLD. This study retrospectively included individuals who underwent health examinations and abdominal ultrasound from July 2021 to June 2024 at the Affiliated Hospital of Southwest Med...

Introducción. El objetivo principal de este estudio fue determinar la prevalencia de la esteatosis hepática en una población adulta colombiana, sin antecedentes patológicos conocidos, utilizando los valores de densidad de la tomografía contrastada como prueba diagnóstica. Además, se buscó comparar estos resultados con las características demográfi...

Background/Objectives: It remains inconclusive whether or not smoking is associated with an increased risk of fatty liver disease (FLD). We investigated the association between smoking and the risk of FLD by using a meta-analysis of cohort studies. Methods: PubMed and EMBASE were searched using keywords from their inception to September 2023 to ide...

Liver enzymes are associated with liver function, but their relationship with body mass index (BMI) remains unclear. This cross-sectional study aimed to identify correlations between serum liver enzyme levels and BMI in the general population. The data were derived from the Dryad Digital Repository. Smooth curve and multiple linear regression analy...

The connections between sarcopenia and various chronic conditions, including type 2 diabetes (T2DM), metabolic syndrome (MetS), and liver disease have been highlighted recently. There is also a high occurrence of sarcopenia in metabolic dysfunction-associated steatotic liver disease (MASLD) patients, who are often disregarded. Both experimental and...

Liver diseases rank among the most prevalent health issues globally, causing significant morbidity and mortality. Early detection of liver diseases allows for timely intervention, which can prevent the progression of such disease to more severe stages such as cirrhosis or liver cancer. To this end, many machine learning models have been previously...

Background and aim Patients with chronic liver disease are prone to experiencing electrolyte imbalances as a result of physiological changes caused by cirrhosis. These imbalances have a detrimental effect on prognosis, morbidity, and mortality. This study aimed to assess the serum concentrations of sodium, calcium, and potassium in patients with li...

Introduction: Surgical resection remains a primary treatment for liver diseases, requiring precise preoperative planning due to the liver's complex anatomy. Traditional imaging techniques like CT and MRI provide essential information but have limitations in spatial visualization. The emergence of 3D-printed liver models (3DPLMs) offers a novel appr...

Purpose: Coronavirus disease 2019 (COVID-19) is a viral disease, causing a deadly situation around the world. Significant cases need hospitalization and intensive care. Obese, diabetic, and immunosuppressed people have poor prognosis. Here, we are establishing the link between liver disease and COVID-19. Methods: A thorough investigation was perfor...

Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a public health threat as it affects approximately 38% of the adult population worldwide, with its prevalence rising in step with that of obesity and type 2 diabetes. Beyond the implications of MASLD for liver health, it is also associated with cardiovascular and vascul...

Present study reports the etiological spectrum of viral hepatitis in different types of liver diseases in north India.Sera from a total number of 370 adult patients belonging to various liver diseases were analysed for differentmarkers of hepatitis virus A, B, C, D and E infections. These sera were also tested to detect Torque Teno Virus(TTV) infec...