Science topic

Lipids - Science topic

Explore the latest publications in Lipids, and find Lipids experts.
Filters
All publications are displayed by default. Use this filter to view only publications with full-texts.
Article
Full-text available
Ferroptosis, a novel non-apoptotic form of cell death, can induce tumor cell death and treatment resistance. Lipid metabolism is closely related to ferroptosis; however, the effect of mammary adipocytes on breast cancer ferroptosis remains to be elucidated. Here, we established the co-culture system of adipocyte-breast cancer cells and revealed the...
Article
Full-text available
EV produced by tumour cells carry a diverse population of proteins, lipids, DNA, and RNA molecules throughout the body and appear to play an important role in the overall development of the disease state, according to growing data. Gliomas account for a sizable fraction of all primary brain tumours and the vast majority of brain malignancies. Gliob...
Article
Full-text available
Water plays a vital role in biological metabolism and it would be essential to trace the water content non-invasively, such as leveraging the vibrational absorption peak of the O–H bond. However, due to the lack of an efficient laser source, it was challenging to image the water content in the deep tissue with micron-level spatial resolution. To ad...
Article
Full-text available
While conventional chemical fungicides directly eliminate pathogens, plant immunity inducers activate or prime plant immunity. In recent years, considerable progress has been made in understanding the mechanisms of immune regulation in plants. The development and application of plant immunity inducers based on the principles of plant immunity repre...
Article
Full-text available
Oral glucose ingestion induces systemic changes of many blood metabolites related not only to glucose, but also other metabolites such as amino acids and lipids through many blood hormones. However, the detailed temporal changes in the concentrations of comprehensive metabolites and hormones over a long time by oral glucose ingestion are uncharacte...
Article
Full-text available
We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control grou...
Article
Full-text available
Ferroptosis is a regulated iron-dependent cell death characterized by the accumulation of lipid peroxidation. A myriad of facets linking amino acid, lipid, redox, and iron metabolisms were found to drive or to suppress the execution of ferroptosis. However, how the cells decipher the diverse pro-ferroptotic stress to activate ferroptosis remains el...
Article
Full-text available
Background Previous studies on the relationship between the visceral adiposity index (VAI) and peripheral arterial disease (PAD) are limited. Therefore, this study explored the relationship between VAI and PAD in normal-weight patients with hypertension. Methods A total of 6615 normal-weight patients with hypertension were included in the current...
Article
Full-text available
Purpose of Review Despite improvements in treatment, people with type 1 diabetes continue to have increased cardiovascular disease (CVD) risk. Glycemic control does not fully explain this excess CVD risk, so a greater understanding of other risk factors is needed. Recent Findings The authors review the relationship between glycemia and CVD risk in...
Article
Full-text available
Messenger RNA (mRNA) vaccines represent a new, effective vaccine platform with high capacity for rapid development. Generation of a universal influenza virus vaccine with the potential to elicit long-lasting, broadly cross-reactive immune responses is a necessity for reducing influenza-associated morbidity and mortality. Here we focus on the develo...
Article
Full-text available
Atherosclerotic cardiovascular disease is a growing threat among cancer patients. Not surprisingly, cancer-targeting therapies have been linked to metabolic dysregulation including changes in local and systemic lipid metabolism. Thus, tumor development and cancer therapeutics are intimately linked to cholesterol metabolism and may be a driver of in...
Article
Full-text available
RNA-delivery is a promising tool to develop therapies for difficult to treat diseases such as neurological disorders, by silencing pathological genes or expressing therapeutic proteins. However, in many cases RNA delivery requires a vesicle that could effectively protect the molecule from bio-degradation, bypass barriers i.e., the blood brain barri...
Article
Full-text available
Lipids are essential constituents for malignant tumors, as they are absolutely required for tumor growth and dissemination. Provided by the tumor microenvironment (TME) or by cancer cells themselves through activation of de novo synthesis pathways, they orchestrate a large variety of pro-tumorigenic functions. Importantly, TME cells, especially imm...
Article
Full-text available
Individuals with South Asian ancestry have a higher risk of heart disease than other groups but have been largely excluded from genetic research. Using data from 22,000 British Pakistani and Bangladeshi individuals with linked electronic health records from the Genes & Health cohort, we conducted genome-wide association studies of coronary artery d...
Article
Full-text available
Purpose This study evaluated whether optical frequency domain imaging (OFDI) accurately distinguish between fibroatheroma (FA) and pathological intimal thickening (PIT) compared with histopathology. Methods A total of 631 histological cross-sections from 14 autopsy hearts were analyzed for the comparison between OFDI and histological images. Of th...
Article
Full-text available
Background Coronary artery disease (CAD) is a complex disease that is influenced by environmental and genetic factors. Lipid levels are regarded as a major risk factor for CAD, and epigenetic mechanisms might be involved in the regulation of CAD development. This study was designed to investigate the association between the DNA methylation status o...
Article
Full-text available
An experiment was conducted to evaluate the Specific Growth Rate (SGR) and affiliated physico-chemical attributes of Spirulina platensis in supernatant of three different concentrations of digested rotten guava (DRG), and Kosaric Medium (KM) as control. Three different concentrations such as 20, 40 and 60 rotten guavas were allowed to digest under...
Article
Full-text available
Quantification of lipid and their related enzymes was studied in Lentil (lens culinaris medic) infected with Fusarium oxysporum F. Sp. lentis causing wilt disease. The contents of total lipid and lipase activities in healthy and diseased counter parts of lentils were measured. Different plant parts showed variation in their lipid contents were reco...
Article
Full-text available
Meibomian gland dysfunction (MGD), a chronic abnormality of meibomian glands, causes various dry eye symptoms. Principal treatments for MGD are warm compression and mechanical squeezing of the eyelids. In this study, the immediate impact of this treatment on tear film lipid layer thickness (TFLLT) and the meibomian gland (MG) structure in MGD and n...
Article
Full-text available
Apple pomace was used as a sole raw material for single cell oil (SCO) production by the oleaginous yeast Rhodosporidium toruloides DSM 4444. Preliminary studies with glucose medium revealed 100 mL of working volume in 500 mL Erlenmeyer flask as the most efficient in terms of lipid content. Thus, apple pomace hydrolysate was tested in six different...
Article
Full-text available
The plasma membrane (PM) of cells is a dynamic structure whose morphology and composition is in constant flux. PM morphologic changes are particularly relevant for the assembly and disassembly of signaling platforms involving surface-bound signaling proteins, as well as for many other mechanochemical processes that occur at the PM surface. Surface-...
Article
Full-text available
Atomic-resolution structural studies of membrane-associated proteins and peptides in a membrane environment are important to fully understand their biological function and the roles played by them in the pathology of many diseases. However, the complexity of the cell membrane has severely limited the application of commonly used biophysical and bio...
Article
Full-text available
Purpose Early-onset, multigenerational diabetes is a heterogeneous disease, which is often simplistically classified as type 1 diabetes (T1D) or type 2 diabetes(T2D). However, its clinical and genetic characteristics have not been clearly elucidated. The aim of our study is to investigate the clinical features of early-onset diabetes involving thre...
Preprint
Full-text available
Integrin is an important transmembrane receptor protein which remodels the actin network and anchors the cell membrane towards the extracellular matrix via mechanochemical pathways. The clustering of specific lipids and lipid-anchored proteins, which is essential for a certain type of endocytosis process, is facilitated at integrin-mediated active...
Article
Full-text available
Background Familial hypercholesterolemia (FH) is a codominant autosomal disease characterized by high low-density lipoprotein cholesterol (LDLc) and a high risk of premature cardiovascular disease (CVD). The molecular bases have been well defined, and effective lipid lowering is possible. This analysis aimed to study the current major causes of dea...
Article
Full-text available
The catalytic performance of Ni catalyst in lipid deoxygenation into green diesel is commonly limited by the quantity of accessible active sites, the specific surface area, and the acidity of the catalyst. To cope with these problems, the Fe-promoted Ni catalyst on ZrO2 with 60 wt% Ni loading (60%Ni–Fe/ZrO2) is synthesized by the co-precipitation m...
Article
Full-text available
Dissipative particle dynamics simulations were performed to investigate the self-assembly of dipalmitoylphosphatidylcholine (DPPC) as a model lipid membrane on the surface of carbon nanotubes (CNTs). The influence of surface curvature of CNTs on self-assembly was investigated by performing simulations on solutions of DPPC in water in contact with C...
Article
Full-text available
Although azoxystrobin has been widely applied on various crops, little is known about the bioavailability of azoxystrobin in the soil-vegetable system. In this study, the uptake, accumulation and translocation of azoxystrobin as affected by soil characteristics and plant species were respectively investigated. The accumulation amount of azoxystrobi...
Article
Full-text available
We investigated the change in skin temperature of treated areas during intense pulsed light (IPL) treatment in patients who have meibomian gland dysfunction (MGD) to determine whether there is superficial telangiectatic blood vessel ablation. The medical records of 90 patients (90 eyes) with MGD who underwent IPL treatment were reviewed. The patien...
Article
Full-text available
The objective of this study was to determine the relationship of urinary nickel (U-Ni) exposure to serum lipid profiles and the mediation effect of body mass index (BMI) in a US general population. We analyzed the cross-sectional data from 3517 participants in the National Health and Nutrition Examination Survey (NHANES) (2017-March 2020). Multivar...
Article
Full-text available
Abstract An experiment was conducted to evaluate the fatty acid profile of subcutaneous fat from barrowS of same genetic lineage supplemented with organic chromium and selenium initiated in different weight ranges in the finishing phase using 24 carcasses. Three different diets were used that represent the time when supplementation starts: control...
Article
Full-text available
Purpose To report on the preliminary outcomes of mitomycin C (MMC) intravascular chemoembolization (MICE) for corneal neovascularization (NV). Methods This is a retrospective case series of three consecutive eyes that underwent MICE for progressive corneal NV with sight threatening lipid keratopathy. A 1.0 cc syringe was partially filled with MMC...
Article
Full-text available
Objective: Women with a history of pre-eclampsia have an elevated lifetime risk of cardiovascular disease that may be partly attributed to an adverse cardiovascular risk factor profile, the etiology of which is unclear. Hypothesizing that this adverse risk profile may begin to arise over time in the years before pregnancy, we sought to evaluate th...
Article
Full-text available
Background While Roux-en-Y gastric bypass (RYGB) is effective in achieving weight loss and improving obesity-related co-morbidities, insufficient weight loss in the long-term can occur. The goal was to assess whether banded vs. non-banded RYGB reduces the risk of insufficient weight loss at 5-year follow-up. Methods This is a retrospective single-...
Article
Full-text available
In this work two-stage cultivation of Scenedesmus acuminatus to enhance lipid productivity was investigated. Two two-stage cultivation strategies were employed: 1) S. acuminatus was cultured in nitrogen-limited conditions (0.75 g L⁻¹ NaNO3, stage I), then nitrogen-limited condition (stage II); 2) S. acuminatus was cultured in sulfur-replete conditi...
Article
Full-text available
Pola makan tidak seimbang merupakan salah satu pemicu terjadinya abnormalitas profil lipid, yang merupakan prediktor dari Penyakit Jantung Koroner (PJK). Penelitian ini bertujuan untuk mengetahui hubungan asupan dan frekuensi konsumsi serat, vitamin B3, PUFA dengan profil lipid danpenyakit jantung koroner. Metode penelitian adalah studi literatur d...
Article
Full-text available
Addressing factors modulating COVID-19 is crucial since abundant clinical evidence shows that outcomes are markedly heterogeneous between patients. This requires identifying the factors and understanding how they mechanistically influence COVID-19. Here, we describe how eleven selected factors (age, sex, genetic factors, lipid disorders, heart fail...
Article
Full-text available
This editorial article belongs to the Special Issue Diacylglycerol Kinases in Signal Transduction In lieu of an abstract, this is an excerpt from the first page: "In recent years, the significant research efforts put into the clarification of the PI3K/AKT/mTOR pathway resulted in the approval of the first targeted therapies based on lipid kinase...
Article
Full-text available
One of the main characteristics of cancer cells is the alteration in lipid composition, which is associated with a significant monounsaturated fatty acids (MUFAs) enrichment. In addition to their structural functions in newly synthesized membranes in proliferating cancer cells, these fatty acids are involved in tumorigenic signaling. Increased expr...
Article
Full-text available
Purpose of Review To report on recent data about PCSK9 monoclonal antibodies and to evaluate their relevance in a nucleic acid–based therapy era for lipid lowering and prevention of cardiovascular disease. Recent Findings New methods of PCSK9 inhibition based on nucleic acid therapeutics such as antisense oligonucleotides, small interfering RNAs,...
Article
Full-text available
Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in the inflammation environment, preventing an overreaction of the organism and promoting the resolution of inflammation. Our purpose was to point out the current evidence for specia...
Article
Full-text available
Abstract This study aims to evaluate levels of D-dimer and serum lipid in different types of pancreatitis, and the relationship between D-dimer and dyslipidemia, especially triglyceride to HDL-C ratio (TG/HDL-C) in different types of pancreatitis. We analyzed the D-dimer and dyslipidemia levels in acute pancreatitis (AP), recurrent acute pancreatit...
Article
Full-text available
Background Fatty acids have diverse immunomodulatory functions and the potential to be associated with inflammatory responses in sarcoidosis. Methods The serum levels of multiple long-chain fatty acids (LCFAs) were compared between 63 patients with sarcoidosis and 38 healthy controls. The associations of LCFAs with clinical outcomes of sarcoidosis...
Preprint
Full-text available
Bioanalytical techniques for the isolation and quantification of total lipids in biological samples are an integral part of lipidomic workflows and widely used tools for metabolic assessment at the cellular and organismic levels. The most widely used protocol for the isolation, extraction, and quantification of total lipids in biological tissues wa...
Article
Full-text available
Background The role of longitudinal temporal trends in LDL-C in cardiovascular disease (CVD) in patients with chronic kidney disease (CKD) and diabetes is unclear. This study categorized the long-term LDL-C trajectory and determined its association with the incidence of atherosclerotic CVD in patients with CKD according to diabetes status and estim...
Article
Full-text available
Nonalcoholic fatty liver disease (NAFLD) has become one of the public health problems globally. The occurrence of NAFLD is usually accompanied by a series of chronic metabolic diseases, with a prevalence rate is 25.24% among adults worldwide. Therefore, NAFLD seriously affects the quality of life in patients and causes a large economic burden. It h...
Article
Full-text available
Background: Alteration in glycosphingolipids (GSLs) in Parkinson’s disease (PD) still needs to be determined. Objectives: We evaluated if PD subjects show abnor�mal GSLs levels compared to healthy controls (HC) and if GSLs correlate with clinical features. Methods: We analyzed GSLs and glucosylceramide (GlcCer) in plasma using two normal-phase hi...
Article
Full-text available
Background: Clinical data on the correlation of dyslipidaemia with the long-term outcomes of ulcerative colitis (UC) are limited. This study aimed to evaluate the impact of lipid levels on disease activity and prognosis in UC. Methods: The retrospective data of UC patients who had detailed lipid profiles were collected from January 2003 to Septe...
Article
Full-text available
This study aimed to use natural antioxidants (rosemary and curry leaf extracts – AT1 and a mixture of tocopherols – AT2) in sliced salami to prevent lipid oxidation, preserve physicochemical and sensory characteristics, and increase the shelf life. Five formulations were developed in addition to a control formulation and physical–chemical, microbio...
Article
Full-text available
Hypercholesterolemia is a major risk factor for the initiation and development of non-alcoholic fatty liver disease and atherosclerosis. The present study evaluated the hypocholesterolemic effect of virgin avocado oil (VAO) using urinary metabolomic method. Male Sprague-Dawley rats were fed high-cholesterol diet for four weeks to induce hypercholes...
Article
Full-text available
In order to elucidate whether deep freezing could maintain the quality of snowflake beef, three different deep freezing temperatures (−18 °C, −40 °C, and −60 °C) were used in order to evaluate the changes in tissue structures, quality characteristics and spoilage indexes, and their comparative effects on the quality of snowflake beef. Compared to s...
Poster
Full-text available
Cetaceans are long-lived species that have a fat rich in lipids and are the main predators of marine food chains, therefore, these animals bioaccumulate and biomagnify metals in their organisms (Boon et al., 1994; Garcia-Cegarra et al., 2020). For this reason, numerous studies have used cetaceans as bioindicators of metal contamination (Cáceres-Sae...