Leiomyoma - Science topic

Breast adenoid cystic carcinoma (BACC) is a rare occurrence constituting less than 0.1% of primary breast cancers. BACC is even more rare in male patients. Furthermore, there are currently no concrete treatment guidelines for BACC. Therefore, it is imperative to conduct a thoughtful evaluation and diagnostic workup when a potential case is encounte...

Objective To evaluate if structured reports (SR) of pelvic magnetic resonance imaging (MRI) scans using the PALM‐COEIN FIGO (the International Federation of Gynecology & Obstetrics) uterine leiomyomas classification (SR‐FIGO) contain adequate information for clinical decision making compared with narrative reports (NR). Methods Three reporting tem...

Background: Ethnic underrepresentation in clinical trials can lead to significant health disparities, particularly for conditions like uterine fibroids, which disproportionately affect different ethnic groups. Reporting ethnicity in clinical trials is essential for evaluating their generalisability and treatment effectiveness. The extent to which e...

Background Retroperitoneal leiomyomas are rare, presenting diagnostic challenges. This report describes a case of a rapidly growing retroperitoneal leiomyoma mimicking an adrenal tumor, along with the literature review. Case Presentation A 47-year-old Caucasian woman presented with an incidentally discovered adrenal mass and suspected omental meta...

Background: Uterine fibroids are the most common benign tumours in women of reproductive age group which may present with heavy menstrual bleeding, dysmenorrhea, pelvic pressure and anaemia. Its management depends on the number, size and location of the fibroids, patient’s age and desire to preserve fertility. Ulipristal acetate (UPA) is a selective...

Women of reproductive age may be affected by uterine leiomyomas, sometimes referred to as fibroids, which are non-cancerous growths in the uterus. The cost, adverse effects, and occasionally ineffectiveness of the drugs now on the market are the issues with them. The use of medicinal herbs in the treatment of fibroids provides an efficient substitu...

Background Polypoid endometriosis is rare and differs from classic endometriosis. It has been primarily documented in case reports and often misdiagnosed as malignancy. The aim of this study is to report three separate cases of polypoid endometriosis coincided with multiple abscess, angioleiomyoma or stromal sarcoma, respectively. Case Presentatio...

Context Xiao-Luo-Wan (XLW), a classical prescription in traditional Chinese medicine, has therapeutic effects on uterine fibroids (UFs). Herein, its anti-UF effects were examined using a systematic pharmacological method. Objective To explore the active ingredients of XLW via mass spectrometry and its potential effects on UFs by network pharmacolo...

Objectives: The aim of this study was to construct a diagnostic model from MRI features to distinguish complex leiomyomas/degenerating fibroids (DF) from leiomyosarcoma (LMS). Methods: A retrospective case-controlled study was performed comparing MRI features of patients with pathologically proven DF or LMS. MRI in 42 patients with DF (control grou...

Plain Language Summary What is this summary about? This plain language summary reports results from the LIBERTY 1, LIBERTY 2, and LIBERTY Long-Term Extension clinical studies, looking specifically at outcomes in Black/African American women, as these individuals have uterine fibroids more frequently and more severe disease. These studies examined t...

Objective To analyze the clinicopathological features and prognostic factors of intravenous Leiomyomatosis (IVL), a rare yet recurrent disease. Methods This retrospective observational study enrolled 43 patients with pathologically confirmed IVL. Clinicopathological data were collected and reviewed. Univariate analyses were performed to identify p...

Background Gastric stromal tumors (GSTs) and gastric leiomyomas (GLs) represent the primary subtypes of gastric submucosal tumors (SMTs) characterized by distinct biological characteristics and treatment modalities. The accurate differentiation between GSTs and GLs poses a significant clinical challenge. Recent advancements in artificial intelligen...

During the reproductive stage, uterine fibroids, which are benign smooth muscle tumors, can significantly impact a woman's quality of life. Pharmacologic treatment and surgical procedures like myomectomy and hysterectomy are included in traditional management. Radiofrequency ablation (RFA) has been a popular minimally invasive method for treating b...

Purpose of Review In this review, we aim to provide a thorough and up-to-date overview of the instrumentation and techniques currently available for hysteroscopic myomectomy and polypectomy. By comparing the efficacy, safety, and practicality of various approaches, we will explore how these innovations have contributed to improved patient outcomes....

Objective Tricho-rhino-phalangeal syndrome-1 (TRPS1), an atypical GATA transcription factor, plays a critical role in diverse physiological and pathological processes and holds potential as a biomarker for diseases and targeted tumor therapies. This study explores TRPS1 expression in ovarian clear cell carcinoma (OCCC), its correlation with patient...

Purpose To develop deep learning models for automated detection and segmentation of uterine fibroids using multi-orientation MRI. Methods Pre-treatment sagittal and axial T2-weighted MRI scans acquired from patients diagnosed with uterine fibroids were collected. The proposed segmentation models were constructed based on the three-dimensional nnU-...

Background and study aims Endoscopic intermuscular dissection (EID) is associated with higher rates of negative margins in treating rectal neuroendocrine tumors (R-NETs), as reported in case studies. However, evidence regarding the safety and effectiveness of EID remains insufficient. This study aimed to evaluate clinical safety and effectiveness o...

The impact of hyperproliferative uterine diseases (HPD), including uterine leiomyoma (LM), uterine endometriosis (adenomyosis) (A), and endometrial hyperplastic processes (such as polyps and/or endometrial hyperplasia (PE and/or GE)) present prior to pregnancy, particularly their combination, on pregnancy outcomes remains a pressing issue in modern...

This article reports the clinical diagnosis and treatment of a 42-year-old female patient with a giant cervical leiomyoma, a rare condition. A review of the literature over the past 30 years reveals only one reported case of a cervical interstitial leiomyoma larger than 20 cm. The surgical removal of such a large cervical smooth muscle tumor poses...

Esophageal leiomyomas are rare, benign tumors that can remain asymptomatic or cause dysphagia and chest discomfort when they grow large. Despite advancements in diagnostic and therapeutic strategies, optimal management remains debated. This systematic review evaluates current diagnostic modalities and treatment approaches, synthesizing findings fro...

Objectives: Inflammatory fibroid polyps, also known as Vanek’s tumors, are rare benign lesions of the gastrointestinal tract. Although the exact cause remains unclear, several theories suggest an association with inflammatory processes and genetic factors. This study aims to present the largest cohort of inflammatory fibroid polyp cases to date, an...

Benign metastasizing leiomyomatosis (BML) is a rare condition characterized by extrauterine lesions with metastatic behavior in patients with a history of uterine leiomyomas. We present the case of a 52-year-old woman with a history of postpartum hysterectomy for necrotic myoma, who presented with cough and right thoracic pain. Computed tomography...

COMBINED RELUGOLIX TREATMENT FOR HIGHLY SYMPTOMATIC UTERINE LEIOMYOMA PATIENTS (Abstract): Many conservative treatments for symptomatic uter-ine leiomyoma have been proposed but in the large majority of cases these are often limited by the associated side effects. A relative novel treatment with GnRH antagonists has been reported in the literature...

A common sonographic characteristic in peri- and postmenopausal women is a sonographically bulky uterus, often associated with diverse uterine abnormalities, necessitating histopathological evaluation. Objective: To assess the histopathological changes in hysterectomy samples of peri- and post-menopausal females with sonographically enlarged uterus...

adenomyoma, while others include cystic degeneration of fibromyomas, congenital Müllerian cysts, and other anomalies of Müllerian structures, such as a rudimentary uterine horn 3. Adenomyotic cysts are typically associated with ade-nomyosis. They correspond to ectopic endometrial glands and stroma and are generally small (2 to 5 mm), located at a m...

Background Uterine contractions, also known as peristalsis, have been shown to affect fertility. However, despite previous studies, most clinicians have not paid sufficient attention to uterine peristalsis. Recent studies have recognised its importance and evaluated contractility parameters prior to embryo transfer. Method A systematic literature...

Background: Transvaginal sonography is a popular method to diagnose adenomyosis, leiomyoma and other pathology of uterus which ultimately lead to hysterectomy operative procedure. This prospective study was conducted in the Department of Radiology and Imaging, Bangabandhu Sheikh Mujib Medical University (BSMMU) to evaluate the accuracy of various t...

Background There are no specific guidelines regarding the definition, diagnostic workup and treatment of recurrent pregnancy loss (RPL) in China at present. Whether the diagnostic workup should occur after two or three or more pregnancy losses in the Chinese population is not clear. Methods This cross-sectional study collected data from January 20...

Benign smooth muscle tumours, known as leiomyomas, are comparatively frequent, with uterine cases accounting for 95% incidence. Oral leiomyomas typically appear as asymptomatic, slowly-growing submucosal lumps in the tongue, hard palate, or buccal mucosa. Three histologic kinds of leiomyomas are recognized: epithelioid leiomyoma, solid leiomyoma, a...

Introduction: Lazarus phenomenon is rare, and a dramatic occurrence characterised by a delayed return of spontaneous circulation after cardiopulmonary resuscitation is terminated. We report a case of this rare phenomenon. Case Presentation: A 45-year-old unemployed man with haemorrhagic pericardial effusion developed iatrogenic perforation of the r...

Cornual ectopic pregnancy is a rare but potentially life-threatening condition that often requires prompt intervention. Uterine artery embolization (UAE) has emerged as a valuable treatment modality for controlling haemorrhage and preserving the uterus. However, UAE can compromise endometrial and ovarian function, potentially leading to infertility...

Uterine inversion during puerperium is an obstetric emergency, and it is an even rarer complication posing a diagnostic challenge in gynaecology. Non puerperal uterine inversion is mostly associated with benign uterine pathology such as leimyomas. Treatment depends on the associated pathology and stage of inversion. A rare case of acute non-puerper...

Uterine leiomyomas, commonly known as fibroids, are the most prevalent pelvic tumors in females, affecting 20%–30% of women of reproductive age. These fibroids can lead to significant symptoms and morbidity. Vaginal fibroids are rare as primary vaginal tumors; approximately 300 cases have been documented in medical literature to date. Notably, ther...

Objective To assess the advantages of High-Intensity Focused Ultrasound (HIFU) in the treatment of uterine leiomyomas and adenomyosis. Methods Patients with uterine leiomyomas (435 cases) and adenomyosis (78 cases) treated in our hospital from March 2020 to October 2023 were selected to receive non-invasive treatment with HIFU. Clinical symptom im...

Background: Postmenopausal bleeding is defined as blood loss occurring at least 12 months after menopause. Aims and objectives were to assess the clinical usefulness and diagnostic accuracy of ultrasonographic measurement of endometrial thickness (ET) in women with postmenopausal bleeding. Methods: It was a prospective study that took place at Gove...

Ovarian serous borderline tumors (SBTs) are typically diagnosed through imaging techniques such as ultrasound and magnetic resonance imaging (MRI); however, diagnosis can be challenging when the tumor exhibits unusual growth patterns or is of small size. We report the case of a 55-year-old woman in whom bilateral SBTs were discovered during surgery...

Background The advantage of robot-assisted hysterectomy over standard laparoscopy remains controversial. Conventional robots offer limited flexibility to the surgeon. The novel, Dexter robotic system™, allows integration and easy switch between the laparoscopic and robotic interface. Objectives This study’s objective is to evaluate the feasibility...

Perivascular epithelioid cell tumors (PEComas) represent rare mesenchymal neoplasms with dual myomelanocytic differentiation. We report a case of a uterine PEComa in a female patient presenting with chronic abnormal vaginal bleeding initially attributed to leiomyoma. The patient underwent abdominal excision of the leiomyoma, and gross examination r...

Cutaneous leiomyomas (CLs) are rare benign tumors of smooth muscle origin, often presenting as painful papulonodules. Piloleiomyomas, a common subtype, arise from the arrector pili muscles. Although generally benign, they may be associated with hereditary conditions such as Reed syndrome, linked to fumarate hydratase gene mutations, which increase...

Leiomyoma is a benign tumour that frequently affects the genitourinary and gastrointestinal systems in adults. Cutaneous leiomyomas are rare benign tumours that originate from the hair follicle’s arrector pili muscle. Adults are more likely than children to develop cutaneous leiomyomas. There are three types: piloleiomyoma, dartoic leiomyoma and an...

Uterine leiomyomas are noncancerous smooth muscle neoplasms that occur in up to 70% of women and the single most common cause of hysterectomy. There is a variety of treatments available for uterine leiomyomas, including medications, uterine artery embolization, myomectomy, and hysterectomy but surgical treatments predominate. Medical optimization o...

Background: Systemic sclerosis (SSc) is a complex autoimmune disease characterised by vascular alterations, immune dysregulation and fibrosis. Microangiopathy is a hallmark of SSc and can be assessed non-invasively using nailfold videocapillaroscopy (NVC). Case description: This is a case of a 50-year-old Caucasian woman with anticentromere-positiv...

Uterine leiomyomas are the most common benign tumours of the female reproductive system, often asymptomatic, but can cause significant clinical issues such as abdominal pain. This case report highlights the rare occurrence of a unilateral uterine horn torsion in a bicornuate uterus caused by a massive subserosal leiomyoma. Surgical intervention wit...

Introduction: Primary peritoneal clear cell carcinoma (PPCCC) is a rare abdominal tumor, affecting 7 out of every million people. Its vague presenting signs and symptoms often lead to delayed diagnosis and poor prognosis. We present a case involving a young woman with anemia and abdominal discomfort who on further investigation had a 26-cm abdomina...

Objective: To determine the effect of administration of pre-operative rectal misoprostol in reducing intra-operative blood loss during abdominal myomectomy in comparison to no treatment. Study design: Randomized controlled trial (single blind) (NCT05108597 at Clinicaltrials.gov) Place and Duration of the Study: Obstetrics and Gynecology department,...

Skene’s glands are recognised as the female equivalent of the male prostate gland. They can be affected by a variety of benign, inflammatory, or malignant conditions. This review critically analyses the current literature on the diagnosis and management of non-malignant lesions associated with Skene’s gland. A comprehensive search of Scopus, Web of...

Infertility remains a significant public health burden in Nigeria and the developing world. Uterine factors are known to contribute significantly to pregnancy outcomes. Hysteroscopy is regarded as the Gold Standard for diagnosing and treating uterine factor infertility. The current consensus is for the application of diagnostic hysteroscopy to pati...

Objective To quantify the burden of poor reproductive health in England by age, ethnicity, and financial security. Design Cross‐sectional survey. Setting England. Sample 59 332 women and people assigned female at birth aged 16–55 years. Methods The Reproductive Health Survey for England 2023 (RHSE2023) used an online convenience sampling strate...

Background Organochlorine pesticides (OCPs) are extensively dispersed throughout the environment, which potentially have harmful impacts on the female reproductive system. Therefore, the purpose of this study was to clarify the association between exposure to OCPs and the history of uterine fibroids in American women. Methods The present study com...

Uterine fibroids (UFs) are the most common benign tumors in women of reproductive age and one of the leading causes of hysterectomy in Italy. This survey aimed to report how Italian women perceive and approach UFs, in order to raise healthcare professionals (HCPs)’, institutions’ and women’s awareness of UFs and their treatment options. 1508 Italia...

Background Currently high-intensity focused ultrasound (HIFU) is widely used to treat uterine fibroids (UFs). The aim of this study is to develop a machine learning model that can accurately predict the efficacy of HIFU ablation for UFs, assisting the preoperative selection of suitable patients with UFs. Methods This study collected data from 1,00...

One common gynaecological issue that can have a major effect on women's reproductive health and quality of life is uterine fibroids (UF). For individualized treatment planning and the reduction of long-term consequences, early fibroids prognosis and recurrence prediction are essential. Conventional techniques for predicting the prognosis and recurr...

Benign smooth muscle tumours of the female genital tract are relatively common lesions, but they are not often encountered in other tissues. All the histopathological specimens received in the Department of Pathology at SCB Medical College, Cuttack, Odisha, India, were examined from March 2023 to March 2024. Cases histopathologically diagnosed as l...

Management of a Giant Uterine Leiomyoma in a woman with Previous Live Renal Transplant.

Background The abdominal wall is one of the rare sites of endometriosis, and its clinical incidence is increasing year by year with the increasing cesarean section rate nowadays. Methods A retrospective analysis was made on patients with abdominal wall endometriosis who attended Changzhou Second Hospital of Nanjing Medical University from January...

Available online xxx Keywords: Adenolipoleiomyoma Uterine polyp Postmenopausal bleeding a b s t r a c t Adenolipoleiomyoma is an extremely rare benign uterine tumor composed of smooth muscle, adipose tissue, and glandular components. This case report enriches the limited scientific literature by detailing its presentation, diagnosis, and management...

Uterine fibroids (UFs) are the most common benign gynecologic tumours affecting women of reproductive age. This study aims to deepen the understanding of UFs complex aetiology through harnessing the power of 3D organoid models derived from human myometrial stem cells to emulate the in vivo behaviour of these tumours. Isolated SCs were cultured over...

Background The occurrence of ectopic prostatic tissue in the female genital tract is an extremely rare condition, usually discovered incidentally. This anomaly has been reported in various parts of the genital tract, including the uterus, cervix and vagina, and is believed to be related to embryonic remnants or metaplastic alterations of normal tis...

Case report: 35-year-old female patient with no relevant history. She presents with lower urinary tract symptoms starting with decreased urinary stream caliber, straining sensation when urinating, urgency, urinary tract infections and dyspareunia. Surgical intervention for clinical resolution. Relevance: leiomyoma is a benign neoplasm of mesenchyma...

Background Neuroendocrine neoplasms are a group of neoplasms often originating from the neuroendocrine cells in the gastrointestinal tract, pancreas, and respiratory tract. Neuroendocrine neoplasms rarely occur in female reproductive organs and less than a hundred cases of ovarian high-grade lesions have been reported in the literature so far. Fewe...

MED12, a critical subunit of the mediator (MED) complex, plays a central role in transcriptional regulation by bridging signal-dependent transcription factors and RNA polymerase II. Dysregulation of MED12, often through mutation, has emerged as a significant driver in various cancers, including uterine leiomyomas, breast cancer (B.C.), and prostate...

Background Adenomyosis is a condition characterized by the presence of endometrial glands and stroma within the myometrium. It can manifest as either focal or diffuse. While histopathological examination of the uterus following hysterectomy remains the gold standard for definitive diagnosis, non-invasive imaging techniques, particularly magnetic re...

In spite of availability of many conservative methods to treat various benign gynaecological disorders, hysterectomy remains the mainstay of treatment. This is a hospital based Cross sectional study on 200 cases of elective hysterectomies carried out in the department of Obstetrics & Gynaecology, Fakir Mohan Medical College and Hospital Balasore, O...

Introduction Ulipristal acetate (UPA, 5 mg) demonstrated efficacy in symptom reduction for patients with symptomatic fibroids. While registration and post-marketing trials assessing UPA identified few hepatic concerns, post-marketing concerns about potential drug-induced liver injury (DILI) led to significant restrictions, including indication rest...

Purpose To investigate the relationship between hepatic steatosis index (HSI) and endometrial cancer (EC) and its diagnostic value for EC. Patients and Methods A total of 114 patients with pathologically diagnosed EC in Mindong Hospital, Ningde City, Fujian Province from 2016 to 2022 were retrospectively included as the EC group. A total of 175 pa...

This study aims to explore the perceptions of reproductive-age women in Greater Accra, Ghana, regarding uterine fibroids. Utilizing a qualitative research approach grounded in the Information-Motivation-Behavioral Skills Model (IMB) and the Health Belief Model (HBM), the study employed phenomenological research design to understand participants' li...

Small bowel obstruction is a surgical emergency that can be caused by many pathological processes even though the leading cause of such an obstruction is an adhesion/adhesions that have occurred following a previous surgery. The second most common cause is an incarcerated hernia. We present an interesting medical case involving a 72-year-old male p...

Background: Infertility is presently characterized as a year of unintended non-conception with unprotected sexual intercourse during the fertile phase of menstrual cycles. It refers to the inability of women of reproductive age to conceive due to the consistent penetration of functional, active sperm into the reproductive organs via artificial or n...

Background: Despite the growing acceptance of uterine artery embolization (UAE) to treat women with fibroid disease, its wider use remains limited because it is not considered to be a definitive therapy, as opposed to surgical treatments such as myomectomy or hysterectomy. Given the evolution of health care towards outpatient medicine, it is critic...

Epididymal leiomyoma is an exceptionally rare benign neoplasm originating from the smooth muscle of the epididymis. Due to its rarity and nonspecific clinical presentation, it poses significant diagnostic challenges. This case report describes a 50-year-old male who presented with a painless, progressively enlarging swelling in the right hemiscrotu...

Background To explore the impact of enhanced recovery after surgery (ERAS) optimization concept process on the perioperative period of gynecologic laparoscopic surgery. Methods This retrospective observational study included patients who underwent gynecologic laparoscopic surgery based on ERAS concept process optimization (ERAS group) for uterine...

Endometrial cancer is the fourth most common cancer in women in Europe. Its carcinogenesis is a complex process and requires further research. In our study, we focus on finding new and easy-to-diagnose markers for detecting endometrial cancer. For this purpose, we compared the levels of miR-21-5p, miR-205-5p, and miR-222-3p in endometrial cancer ti...

Leiomyomas are generally benign lesions originating from smooth muscle cells. However, paraurethral leiomyomas are a rare occurrence with only a few cases being reported in the literature to date. In view of the scarce existing literature regarding paraurethral leiomyoma, their diagnosis and management pose a peculiar challenge. We, hereby, describ...

AIM: Leiomyomatosis peritonealis disseminata or disseminated peritoneal leiomyomatosis (DPL), is a rare nosological entity characterized by multiple leiomyomas growing within the abdominal region. It is one of the uncommon manifestations of extra-uterine leiomyomas and an eventuality that can lead to diagnostic difficulties, especially in neoplasti...

Introduction The segmentation of uterine fibroids is very important for the treatment of patients. However, uterine fibroids are small and have low contrast with surrounding tissue, making this task very challenging. To solve these problems, this paper proposes a 3D DA- VNet automatic segmentation method based on deep supervision and attention gate...

Previous epidemiological studies have suggested that green tea catechins, including Epigallocatechin‐3‐gallate (EGCG), the most abundant polyphenol in green tea, may be associated with reduced serum folate levels. This is of particular interest as women of childbearing age may be consuming EGCG from tea, dietary supplements, or involved in active c...

This project aims to identify and explain a phenomenon I call pain-related motivational deficit, which occurs when there is proper uptake of the epistemic contributions of a pain utterance, but defective uptake of the motivational contributions of a pain utterance. I argue that the normalization of fibroid pain in Black women, and of menstrual pain...

Purpose Alongside being contraceptives, progestins have been investigated as potential anti-inflammatory and analgesic therapies for use in painful gynaecological conditions. This review aims to synthesise evidence pertaining to the efficacy of progestins as analgesics for use in endometriosis, fibroids and pre-menstrual syndrome (PMS). Methods We...

The genetic background of many female reproductive health diagnoses remains uncharacterized, compromising our understanding of the underlying biology. Here, we map the genetic architecture across 42 female-specific health conditions using data from up to 293,618 women from two large population-based cohorts, the Estonian Biobank and the FinnGen stu...