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Iron Deficiency Anemia - Science topic
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Questions related to Iron Deficiency Anemia
"What are the latest treatments for iron-deficiency anemia, and how do they compare to traditional iron supplements in efficacy and patient adherence?"
Hi everyone
I am currently investigating the effect of iron deficiency on neuronal cells (SHYSY5Y to be exact). For this, I need to create an environment of iron-depletion in-vitro. While past publications have used iron chelators in media, this involves considerable quality control. This is why I am choosing to mimic an iron-deficient environment through serum starvation.
I am currently struggling to find publications outlining a validated method of serum starvation to achieve this, which would be of great help, as a trial- and error method in the lab is time consuming. Another concern is that other essential nutrients would also be depleted with serum starvation, that may affect any findings and therefore impact the validity of results. I am also interested in any iron-depleted media out there that I could potentially use?
Would greatly appreciate any advice, links to publications or methods I could follow.
It is seen that the amount of labile iron is prevented with ferric carboxymaltose and iron isomaltoside, which are the two most up-to-date iron compounds. I wonder if there is a special contribution of maltose derivatives biochemically.
How will you treat a patient with iron deficiency anemia - before the infusion of iron, you will make an intravenous infusion of vitamin C or after, guided by biochemical and pathophysiological principles?
Definition and Background of Helicobacter Pylori Infections
Helicobacter pylori (H. pylori) bacterium is involved in many diseases other than peptic ulcer disease, such as coronary artery inflammation, gastroesophageal reflux disease, skin disease, iron deficiency anemia, rheumatologic issues and lymphoid tissue lymphomas associated with mucosa. It has also been reported that there is a strong association between gastric adenocarcinoma and lymphoma and H. pylori bacterium.
I selected 200 samples from different medical camps to study the exposed population to Iron deficiency anemia, >50 were IDA positive. Rest was negative.I have used all samples to build a comparison study.
Hello! can someone help me with articles for this theme?
Thank you very much for your attention
Iron deficiency and iron deficiency anemia are common children especially in developing countries. For screening we need a test which is sensitive and cheap, so that t can be applied to large number of children, and taking in consideration that the these samples will be withdrawn from children who are apparently healthy.
any research done on a similar topic?
With multiple Red cells transfusions in extreme preterm babies with AOP, Do we still need to give iron supplements? Do we need to measure Ferrritin level?
Is there a reference values of plasma ferritin witth GA? at what level We have not to administer Fe supplements
Please see the following:
The Labile Side of Iron Supplementation in CKD
Itzchak Slotki* and Zvi Ioav Cabantchik†
*Division of Adult Nephrology, Shaare Zedek Medical Center and Hadassah Hebrew University of Jerusalem, Jerusalem,
Israel; and †Department of Biological Chemistry, Alexander Silberman Institute of Life Sciences, The Hebrew University of
Jerusalem, Jerusalem, Israel
ABSTRACT
The practice of intravenous iron supplementation has grown as nephrologists have
gradually moved away from the liberal use of erythropoiesis-stimulating agents
as the main treatment for the anemia of CKD. This approach, together with the
introduction of large-dose iron preparations, raises the future specter of inadvertent
iatrogenic iron toxicity. Concerns have been raised in original studies and reviews
about cardiac complications and severe infections that result from long-term
intravenous iron supplementation.
J Am Soc Nephrol 26: 2612–2619, 2015. doi: 10.1681/ASN.2015010052
It seems that many children with febrile convulsions have iron deficiency anemia , so that iron deficiency may be a risk factor for development of febrile seizures .
Interested especially in data on iron and zinc deficiencies
many children with recurrent febrile seizures have iron deficiency anemia .
Effect of chronic anemia on nutrition and appetite?
Effect of chronic anemia on growth hormone-IGF-I secretion?
Effect of chronic anemia on puberty and pubertal growth spurt ?
I have some mice in which we have induced focal gastrointestinal ulcers with bleeding at least in the first two weeks post injury, and we observed anemia from two weeks to two months post injury. At two months I see complete ablation of bone marrow iron stores using Prussian blue staining but moderately increased tissue iron stores in the spleen and liver. This is accompanied by a reticulocytosis and increased extramedullary hematopoiesis. Does anyone have any explanation for this decrease and increase? And does this fit better with iron deficiency or anemia of chronic disease? I also have increased serum il6 at two weeks post injury which is leading me down the ACD track despite the fairly classic IDA presentation.
I want to know the normal range of the Concentration of the following electrolytes in Albino rat urine samples: Na, Ca, K, Cl, HCO3
I want to calculate the appropriate dose of ferrous sulfate for anemic patient depending on MCV, HB level and his diet ?
I am providing 3ppm iron diet to develop anaemia i rat. after 21 days i found haemoglobin level of rat decreased from 16 to 11 gms%
Thanks in advance for your replies.
Would like to strengthen my knowledge in this field
THERE have been opininons for and against IRON SUPPLEMENTATION IN ANAEMIC CHILDREN WITH MALARIA
Many studies have reported that overweight and obesity are prevalent among children and adolescents with hemophilia and correlate these findings with physical activity. What about underweight and wasting in these patients. I would be grateful if you can supply me with papers with such findings
Okay, so I am doing a study on Iron Deficiency Anemia. In the first phase, I will determine the prevalence and then I need to go for Case control and an RCT. I need to ask if I have to calculate sample size for Case Control and RCT or can I have some standard minimum number of my own choice?
I mean, I have seen a lot of papers where the authors have just taken a certain number of cases and two or three controls per case. So can I take (for example) 50 cases and 100 controls, depending on my prevalence results or is there a specific formula for calculation?
Similar is the case with my Randomized Control Design, that is, can I take a certain number of people to start with or (again) is there any formula?
Thanks.
A 45 years old female with iron deficiency anemia from 8 years ago.at first her response to intravenous iton was good.but now she is not responsed to it.
Gastrointestinal survey was NL.abdominopelvic somography is NL.
Could iron-deficiency anaemia secondary to heavy menstrual bleeding be a potential risk factor to the formation of venous thromboembolism (bilateral PE)?
I encountered two cases within 2 months of obstetrics and gynaecology posting? Especially those were given trenaxamic acid.
Appreciate your comments and thoughts.
In the monograph of Venofer (iron sucrose complex) it is written that 2700 mg iron sucrose complex is equal to 20 mg elemental iron. Could someone help me on this conversion?
Within body cells, which organelle is least likely to function properly in an individual who is anemic?
It was seen that large number of rural women suffering from Anemia. This is major cause of Maternal and infant mortality among rural population.
Hello
I am doing my PhD research on Iron Deficiency Anemia in adolescent females and for that, I need to do detect Anemia. What could be the cheapest but still most reliable method of doing so?
I do not want to go for bio chemical profiling as it is expensive and I do not have any funding. :(
I want to test the efficacy of a certain plants extract on anemic rats.Anybody with useful suggestion on how to induce anemia in rats in the short time like a month or forty days ?
Anyone having access to research papers/ reports, please share with me.
Iron stores are generally assessed using bone marrow aspiration from the iliac crest. However, the sternum is also used to perform aspiration. Are the results comparable in humans? In the cited article, both sample cites are used, did you find any differences?
behaviors , nutritional habits , causes
Other than patient's asthenia, are there other kinds of relationship that may explain iron deficiency anemia and male infertility?
Pagophagia (the consumption of ice) and geophagia (the consumption of soil compounds) are the most common forms of pica, which have often been associated with cases of iron deficiency anaemia. What is the motivation? Which metabolic pathways are interested?
I'm planning a study on blood donors. The study will be in large cohort of blood donors. One objective will be to characterize prevalence and symptoms of low iron in frequent blood donors. Pica is quickly reversible with iron treatment.