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Inflammatory Diseases - Science topic
Explore the latest publications in Inflammatory Diseases, and find Inflammatory Diseases experts.
Publications related to Inflammatory Diseases (10,000)
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Fever is a common clinical symptom that can indicate a variety of underlying conditions, including infections, inflammatory diseases, and other medical disorders. Accurate and timely classification of fever types is crucial for effective diagnosis and treatment. Machine learning (ML) approaches have emerged as powerful tools for analyzing large-sca...
Background/Objectives: Cutaneous T-cell lymphoma (CTCL) is a rare group of non-Hodgkin lymphomas characterized by the clonal expansion of malignant T cells. While current treatments can alleviate symptoms and significant progress has been made
in treating leukemic CTCL, a definitive cure remains elusive. Dysregulation of the Janus kinase/signal tra...
Fever is a common clinical symptom that can indicate a variety of underlying conditions, including infections, inflammatory diseases, and other medical disorders. Accurate and timely classification of fever types is crucial for effective diagnosis and treatment. Machine learning (ML) approaches have emerged as powerful tools for analyzing large-sca...
A infecção por Chlamydia trachomatis é uma das infecções sexualmente transmissíveis (ISTs) mais prevalentes mundialmente, representando um desafio significativo para a saúde pública. Sua transmissão ocorre predominantemente por via sexual, mas também pode ocorrer verticalmente, durante o parto. A infecção está associada a diversas complicações, com...
Background and purpose
Myelin-oligodendrocyte glycoprotein antibody associated disease (MOGAD) is a common inflammatory disease of the central nervous system (CNS) in children that can lead to demyelination. Evaluation and monitoring of biomarkers associated with its pathogenesis would provide vital information on disease progression and therapeuti...
Bradykinin receptor B2 (BDKRB2) is a G protein-coupled receptor (GPCR) that mediates the biological effects of bradykinin, a key peptide in the kallikrein-kinin system. BDKRB2 plays a significant role in vasodilation, inflammation, and pain modulation, making it a critical target for cardiovascular and inflammatory disease research. This paper expl...
Atherosclerosis, a chronic inflammatory disease characterized by the accumulation of lipids and immune cells within arterial walls, remains a leading cause of cardiovas-cular morbidity and mortality worldwide. Oxidative stress and inflammation are central to its pathogenesis, driving endothelial dysfunction, foam cell formation, and plaque instabil...
The SOX9 gene locus is not only extensive but also intricate, and it could promote fibrosis in different organs or tissues, including cardiac fibrosis, liver fibrosis, kidney fibrosis, pulmonary fibrosis, as well as other organ fibrosis. Many disorders are associated with the process of fibrosis; moreover, fibrosis is a common symptom of chronic in...
Sono entusiasta di condividere il nostro ultimo lavoro, pubblicato su Frontiers in Microbiology, che esplora l'interazione bidirezionale tra il microbioma intestinale e i microRNA (miRNA) nella regolazione della salute umana e delle malattie croniche. Questa review offre una prospettiva approfondita su come i miRNA possano modulare la composizione...
This review aims to provide a comprehensive overview of the main types, subtypes, clinical manifestations, and current therapeutic strategies for multiple sclerosis, emphasizing recent advancements and clinical challenges. Multiple Sclerosis (MS) is a demyelinating, chronic, autoimmune, and inflammatory disease that affects the Central Nervous Syst...
Familial Mediterranean fever (FMF) is traditionally associated with biallelic mutations in the MEFV gene; however, heterozygous mutations may also contribute to disease phenotypes. We report the case of a 42-year-old woman with heterozygous p.Met694Ile MEFV mutation, presenting with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis i...
Axial spondyloarthritis (ax-SpA) is a chronic inflammatory disease which causes a major deterioration of both physical and mental health. This research aimed to assess the prevalence of sexual dysfunction (SD), decreased quality of life (QoL), and depressive and anxiety symptoms in women with non-radiographic axial spondyloarthritis (nr-axSpA). A c...
Adoptive immunotherapy using engineered T cells expressing chimeric antigen receptors has shown remarkable success in treating patients with hematological malignancies. However, realizing broader therapeutic applications of engineered T cells in other diseases requires further exploration in clinical investigations. In this review, we highlight rec...
Neutrophils release neutrophil extracellular traps (NETs) as part of a healthy host immune response. NETs physically trap and kill pathogens as well as activating and facilitating crosstalk between immune cells and complement. Excessive or inadequately resolved NETs are implicated in the underlying pathophysiology of sepsis and other inflammatory d...
The excessive and uncontrolled release of neutrophil extracellular traps (NETs) is increasingly linked to the pathogenesis of various inflammatory diseases, cardiovascular disorders, and cancers. Real-time, non-invasive detection of NETs is crucial for understanding their role in disease progression and developing targeted therapies. Current NETs d...
Introduction
Kawasaki disease (KD) is a rare systemic inflammatory disease that primarily affects children under the age of five. It is now recognized as the most prevalent cause of acquired heart diseases in children in developed countries.
Objectives
The aim of this study was to evaluate sleep disturbances in patients with KD and identify their...
B-lymphocyte-induced maturation protein 1 (Blimp-1) is a transcription factor that, among other functions, modulates metabolism and helps to regulate antioxidant pathways, which is important in the context of chronic inflammatory diseases like diabetes, cardiovascular disease, and autoimmune disease. In immune cell function, Blimp-1 has a modulator...
Fibroblast-like synoviocytes (FLSs), which are stromal cells that play key roles in rheumatoid arthritis (RA) pathophysiology, are characterized by a tumor-like phenotype and immunostimulatory actions. C2 domains in various proteins play roles in intracellular signaling and altering cellular characteristics, and some C2 domain-containing proteins e...
A psoríase é uma doença inflamatória crônica que acomete 2-3% da população global , caracterizando-se por lesões cutâneas persistentes, desregulação imunológica, e significativa redução na qualidade de vida dos indivíduos afetados. Apesar dos avanços terapêuticos , as opções disponíveis ,como tratamentos tópicos, sistêmicos e biológicos , enfrentam...
Background and Aims
Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects quality of life (QoL) due to its impact on physical and emotional well‐being. Accurate and reliable tools are needed to assess disease activity and QoL in different cultural contexts. This study aimed to evaluate the psychometric properties of the Persian...
AAmine oxidase copper-containing 3 (AOC3), also known as vascular adhesion protein-1 (VAP-1), is an endothelial cell adhesion molecule and enzyme involved in leukocyte trafficking and oxidative deamination of primary amines. Recent research highlights its role in inflammatory diseases, metabolic disorders, and cancer progression. This paper provide...
Obesity is a multifaceted and chronic medical condition characterized by an excessive accumulation of body fat, which adversely affects nearly every organ system in the body. It is associated with a heightened risk of numerous health complications, including but not limited to cancer (e.g., uterine, colon, breast), inflammatory diseases, type 2 dia...
Macrophage immunotherapy is an emerging therapeutic approach designed for modulating the immune response to alleviate disease symptoms. The balance between pro-inflammatory and anti-inflammatory macrophages plays a pivotal role in the progression of inflammatory diseases. Mitochondria, often referred to as the “power plants” of the cell, are essent...
Fibroblast-like synoviocytes (FLSs) and osteoclasts are central cells in the maintenance of joint homeostasis. Rheumatoid arthritis (RA) is a chronic inflammatory disease of joints that induces cytokine-activated FLSs and progressive bone erosion. Interactions between FLSs and other cells, such as T cells and B cells, have been recognized in the de...
Background
Polymyalgia rheumatica (PMR) and giant cell arteritis (GCA) frequently overlap, with each disease potentially presenting as a manifestation of the other. The strong relationship between PMR and GCA raises the question of whether it is a “co-occurrence of different diseases” or a “common spectrum of inflammatory diseases.” The objectives...
Background and Objective
High‐efficacy (HE) disease‐modifying therapies (DMT) are increasingly used to treat multiple sclerosis (MS). Concerns arise when considering the decreasing efficacy and increasing risk of adverse events in aging patients. We aimed to describe disease activity and treatment trajectories in patients with MS who de‐escalated f...
La esterilidad, definida como la incapacidad de lograr un embarazo tras un año de relaciones sexuales regulares sin protección, afecta a una proporción significativa de la población en edad reproductiva en Latinoamérica, donde está influenciada por factores socioeconómicos, culturales y limitaciones en el acceso a servicios de salud reproductiva. E...
Background: Hematological indices such as the neutrophil-lymphocyte ratio (NLR), platelet–lymphocyte ratio (PLR), and systemic immune inflammation index (SII) have been proposed as markers of inflammatory disease and prognostic indicators in some tumors, but their role remains controversial. This study aims to evaluate the relationship between thes...
This study aimed to explore the perceptions of patients and rheumatologists about a treat-to-target (T2T) strategy in axial spondyloarthritis (axSpA) and identify the barriers and facilitators to its implementation in clinical practice. A mixed methods design was applied. Patients with axSpA who visited the outpatient clinic with active disease (Ax...
Background: Rheumatic heart disease (RHD) is a chronic heart valve condition affecting around 40 million people globally. Inflammatory cytokines, acting as messengers, play a role in immune responses in various rheumatic diseases. Anti-inflammatory cytokines, produced by B cells and T cells, act as regulatory molecules controlling pro-inflammatory...
Extracellular vesicles (EVs) are taken up by most cells, however specific or preferential cell targeting remains a hurdle. This study aims to develop an EV that targets cells involved in inflammation, specifically those expressing intercellular adhesion molecule-1 (ICAM-1). To target these cells, we overexpress the ICAM-1 binding receptor “lymphocy...
Discoidin domain receptors (DDR) are categorized under tyrosine kinase receptors (RTKs) and play a crucial role in various etiological conditions such as cancer, fibrosis, atherosclerosis, osteoarthritis, and inflammatory diseases. The structural domain rearrangement of DDR1 and DDR2 involved six domains of interest namely N-terminal DS, DS-like, i...
Previous studies have suggested that systemic viral infections may increase risks of dementia. Whether this holds true for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus infections is unknown. Determining this is important for anticipating the potential future incidence of dementia. To begin to do this, we measured plasma biomar...
Introduction: Psoriasis is a chronic, immune-mediated inflammatory disease that significantly impacts patients' quality of life due to its visible lesions and associated stigma. Psychological comorbidities are prevalent among psoriasis patients. Objectives: This study aimed to evaluate the utility of the Pictorial Representation of Illness and Self...
Background/Objectives: Regenerative periodontal therapy is a treatment method that focuses on restoring the periodontium affected by chronic inflammatory disease or injury. It involves using different biomaterials and techniques to completely restore the periodontal structures. The main objective was to identify and critically evaluate relevant stu...
Diet is considered a possible cofactor, which affects the immune system and potentially causes dysregulation of intestinal homeostasis and inflammation. This study aimed to review the quality of evidence on the effects of specific diet composition on symptoms of immune-mediated inflammatory diseases (IMIDs), including rheumatoid arthritis (RA), spo...
Rheumatoid arthritis (RA) is one of the most common systemic autoimmune inflammatory diseases, with a progressive etiology that results in serious complications and a higher chance of early death. Visfatin, an adipokine, is correlated with disease pathologic features and becomes a key biomarker and therapeutic target for RA. This study aimed to eva...
Background and Objectives: Acute pancreatitis (AP) is an inflammatory disease where there is autodigestion of the pancreas by prematurely activated enzymes which may lead to a systemic inflammatory response. The aim of our study was to investigate the levels of circulating serum leukotriene B4 (LTB4), lipoxin A4 (LXA4), and resolvin D1 (RvD1) in pa...
Acute lung injury (ALI) is an inflammatory disease with a high incidence and prevalence that can lead to death. While L-thyroxine is widely used as a synthetic hormone in the treatment of hypothyroidism, its effects on inflammatory processes are not fully understood. Physical exercise, recommended for the general population, serves as an ally in tr...
Background Ankylosing spondylitis (AS) is a chronic inflammatory disease that significantly affects quality of life and imposes a high economic burden on patients due to the cost of biologic disease-modifying antirheumatic drugs (bDMARDs). Dose reduction strategies for bDMARDs may offer a feasible approach to maintaining clinical efficacy while red...
A Hepatite Autoimune é uma doença inflamatória crônica que afeta principalmente mulheres e pode causar sintomas como náuseas, icterícia e dor abdominal. Se não tratada, pode levar a complicações graves, incluindo cirrose e câncer de fígado. O diagnóstico é baseado em critérios clínicos, bioquímicos e histopatológicos. A HAI relacionada à imunoglobu...
Objective: To evaluate the humoral response to and impact of SARS-CoV-2 vaccination in patients with systemic lupus erythematosus in a multicenter cohort design. Methods: Data for this analysis were obtained from the Study of Safety, Effectiveness and Duration of Immunity after Vaccination against SARS-CoV-2 in Patients with Immune-Mediated Inflamm...
Background/Objectives: Bioactive compounds possess the ability to maintain health and improve diseases by regulating inflammation and cell death processes. Pyroptosis is programmed cell death related to inflammation and exerts a critical role in the development and progression of different types of diseases. This narrative review aims to investigat...
Adalimumab, a monoclonal antibody used for treating inflammatory diseases, including eye diseases, faces challenges in biodistribution and targeted delivery. Nanoparticle (NP)‐based drug delivery systems have shown promise in enhancing the pharmacokinetic profiles of biologic drugs. This study aims to develop, and characterize intravitreal adalimum...
Introdução: A Doença de Behçet (DB) é uma vasculite sistêmica crônica que pode afetar diversos órgãos, incluindo o trato gastrointestinal, onde causa lesões ulcerativas semelhantes às da Doença Inflamatória Intestinal (DII), como a Doença de Crohn (DC) e a Colite Ulcerativa (CU). A semelhança clínica entre essas condições, incluindo sintomas como d...
Background/Objectives: Hidradenitis suppurativa (HS) is an under-treated chronic inflammatory disease that affects approximately 0.40–2% of the population. Despite the competences nurses have in wound care, little is known about their management of HS lesions. The objectives of this study were to determine the knowledge and skills of primary care n...
The microbiome, comprising the diverse microbial communities inhabiting the human body, has emerged as a critical factor in regulating immune function and inflammation. The relationship between the microbiome and uveitis represents a promising frontier in ophthalmological research, with the microbiome increasingly implicated in disease onset and pr...
Xinyao Zhao Du Lehui Na Ma- [...]
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Background and purpose
Radiation-induced lung injury (RILI) limits the efficacy of thoracic radiotherapy. However, the underlying mechanism of RILI remains unclear. cGAS-STING pathway is reported to be involved in the recognization of cytosolic dsDNA and various inflammatory diseases. This study aimed to investigate the role of cGAS-STING pathway i...
Background: Immune-mediated inflammatory diseases (IMIDs) are associated with chronic inflammation that may increase fracture risk; however, their impact within specific populations, such as those with type 2 diabetes mellitus (T2DM), remains unclear. This study aimed to evaluate the association between IMIDs and fracture risk, leveraging a large,...
La psoriasis es una enfermedad inflamatoria crónica, que se caracteriza por placas eritematoescamosas. El objetivo del presente estudio fue caracterizar epidemiológica, clínica y terapéuticamente a los pacientes adultos con psoriasis que acudieron a la consulta externa de Dermatología en el Hospital General San Juan de Dios en el periodo del año 20...
Type 1 Diabetes Mellitus is a complex disorder characterized by autoimmune destruction of insulin-producing pancreatic beta cells. Immune dysfunctional mechanisms underlying its pathogenesis remain elusive. Immuno-toxic lifestyle habits (poor diet, inadequate sleep and lack of exercise) contribute to the pathogenesis of Immune-Mediated Inflammatory...
Free radicals, characterized by the presence of unpaired electrons, are highly reactive species that play a significant role in human health. These molecules can be generated through various endogenous processes, such as mitochondrial respiration and immune cell activation, as well as exogenous sources, including radiation, pollution, and smoking....
A acne vulgaris (AV) é uma doença inflamatória crônica altamente prevalente, afetando até 87% dos adolescentes e 54% dos adultos, com impacto significativo na qualidade de vida. Embora casos leves sejam tratados com terapias tópicas, formas moderadas a graves requerem intervenções sistêmicas, como antibióticos orais ou isotretinoína. A resistência...
Background: Grading scales for vitreous haze are crucial for the diagnosis, monitoring, and management of uveitis. The presence of inflammatory cells within the vitreous cavity is widely recognized as a key indicator of disease activity and severity, offering valuable insights into the underlying inflammatory processes. This mini-review aims to exp...
Background: Arteriovenous fistula (AVF) is the preferred vascular access option for hemodialysis (HD). The latter requires a remodeling process called maturation that can take up to 3 months. Maturation failure is a frequent complication associated with significant morbidity. The prevalence of antiphospholipid antibody (aPL) positivity in HD patien...
Title: Aminas Biógenas como biomarcador diagnóstico en enfermedades inflamatorias intestinalis [Aminas Biógenas como biomarcador diagnóstico en enfermedades inflamatorias intestinales] Authors: Juan A. López-Ayala, María Virtudes López-Ayala, Pablo Navarro-Hernández, Manuel Sánchez-Fernández. Indexing information: European Journal of Health Researc...
Multiple sclerosis (MS) is the most common demyelinating and inflammatory disease of the CNS; it has a global distribution with increasing prevalence [...]
La esclerosis múltiple es una enfermedad inflamatoria desmielizante, autoinmune y crónica del sistema nervioso central, caracterizada por la desmielinización y la posterior neurodegeneración secundaria al daño neuronal por pérdida axonal. Actualmente, sigue siendo una enfermedad de etiología desconocida que afecta a más de 2 000 000 personas. Se as...
Background: The Safety and Immunogenicity of COVID-19 Vaccines in Systemic Autoimmune-Mediated Inflammatory Diseases (SUCCEED) study was created to better understand COVID-19 vaccination in immune-mediated inflammatory disease (IMID). Knowing the frequency of COVID-19 breakthrough infections is important, particularly in IMID. Our objective was to...
Introducción. La enfermedad nasosinusal inflamatoria, tumoral benigna y maligna, es de suma importancia. La rinosinusitis crónica puede presentarse en el 5 % de la población. Los tumores nasales benignos pueden ser de origen epitelial, como los papilomas. Dentro de la enfermedad tumoral maligna nasosinusal, el más frecuente es el carcinoma epidermo...
(1) Pediatric inflammatory multisystem syndrome (PIMS) is a relatively rare complication of coronavirus disease (COVID-19). So far, it is unclear why COVID-19 in children has usually mild or asymptomatic courses, whereas PIMS, which develops several weeks after COVID-19, is a serious life-threatening condition. (2) In this proof-of-concept study, u...
Venous thromboembolism (VTE), major adverse cardiovascular events (MACE), neoplasia, and serious infections are significant complications associated with Immune-mediated inflammatory diseases. Actually, the occurrence of such complications in these patients has been observed to be higher than that anticipated from classical risk factors alone. Addi...
Immune cells adapt their metabolism in response to their differentiation and activation status to meet the energy demands for an appropriate immune response. Recent studies have elucidated that during immune cell metabolic reprogramming, lipid metabolism, including lipid uptake, de novo lipid synthesis and fatty acid oxidation, undergoes significan...
Imaging inflammation holds immense potential for advancing the diagnosis, treatment and prognosis of many conditions1, 2–3. The lack of a specific and sensitive positron emission tomography (PET) probe to detect inflammation is a critical challenge. To bridge this gap, we present CD45-PET imaging, which detects inflammation with exceptional sensiti...
A psοríase é uma doença comum da pele que pode se apresentar com uma variedade de manifestações clínicas. Nos últimos anos, vem sendo reconhecida como um distúrbio inflamatório multissistêmico associado a múltiplas comorbidades, por exemplo, artrite psoriásica, obesidade, síndrome metabólica, hipertensão, diabetes e doença aterosclerótica. O rastre...