Science topic

Inflammation - Science topic

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
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Objective To characterize research on inflammation in CRS over the past 23 years, and analyze trends in hotspots, and collaboration networks. Methods We conducted a methodological, objective, and extensive analysis of inflammation in CRS to track research trends and hotspots. Original research literature published between 2000 and 2023 was obtaine...
Article
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Non-alcoholic fatty liver disease (NAFLD) and its advanced form, non-alcoholic steatohepatitis (NASH), are the leading causes of chronic liver disease globally. They are driven by complex mechanisms where inflammation plays a pivotal role in disease progression. Current therapies, including lifestyle changes and pharmacological agents, are limited...
Article
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A prata tem sido utilizada na medicina há séculos devido às suas propriedades antimicrobianas. Seu uso em curativos popularizou-se por sua capacidade de prevenir e tratar infecções, acelerar a cicatrização e promover a regeneração tecidual. Esta revisão integrativa objetivou analisar os potenciais e as limitações do uso das nanopartículas de prata...
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This study aimed to investigate the associations between inflammatory cytokines and cognitive performance in individuals with depression compared to healthy controls, while accounting for variables, such as perceived fatigue, BMI, and age. Individuals diagnosed with depression (n = 23) and healthy controls (n = 31) were included in the study. A 15-...
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Purpose of Review A subset of acute care surgery patients is emerging wherein surgical intervention can be delayed. These patients need a surgical intervention, but the question of operative timing with regard to nutritional status and nutrition provision remains: should surgery be further delayed for nutritional optimization with parenteral nutrit...
Article
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Background Coronary artery disease (CAD), one of the most prevalent cardiovascular diseases, is a critical health issue that affects millions of individuals worldwide. It has been reported that miR-146b-5p exhibited a strong correlation with inflammatory responses and atherosclerosis. However, its association with the incidence and severity of CAD...
Article
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Cytokines are secreted in response to infection, trauma, or malignancy. Cancer results when cells can no longer regulate their proliferation and differentiation. Cell processes that are linked to cancer development involve bypassing apoptosis, growth suppressors, and immune system regulation, developing new vasculature (angiogenesis), and metabolic...
Article
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Background In SELECT-AXIS 2, upadacitinib improved the signs and symptoms of active non-radiographic axial spondyloarthritis (nr-axSpA) through 52 weeks versus placebo and was well tolerated. Here, we evaluated the efficacy and safety of upadacitinib through 2 years. Methods The study enrolled eligible adult patients with a clinical diagnosis of n...
Article
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Vitamin A has been prescribed in many cases of immunodeficiency or infection, as researchers have found that vitamin A strengthens immunity and regulates immune cells such as neutrophils, macrophages and others. On the other hand, vitamin A treatment did not reduce the length of stay in the hospital or the death-rate sepsis patients. However, vitam...
Article
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High Mobility Group Box 1 (HMGB1), a multifunctional non-histone protein, and its involvement in various physiological and pathological contexts has garnered significant attention. Given HMGB1’s central function in modulating key biological activities, such as inflammatory responses and cellular death, its contribution to the pathogenesis of digest...
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Introdução: O câncer de colo de útero é uma das principais causas de mortalidade entre mulheres, com o HPV oncogênico (tipos 16 e 18) como fator decisivo na sua etiologia. Além do HPV, o microambiente cervical, a resposta imunológica e a microbiota vaginal também influenciam a progressão para o câncer. A vacinação contra HPV representa um marco pre...
Article
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The relationship between heart failure (HF) and immune activation has garnered significant interest. Studies highlight the critical role of inflammation in HF, affecting cardiac structure and function. Despite promising anti‐inflammatory therapies, clinical trials have faced challenges, indicating an incomplete understanding of immune mechanisms in...
Article
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Aneurysmal subarachnoid hemorrhage (aSAH) is a debilitating condition with significant morbidity and mortality rates. Despite advancements in treatment, understanding the underlying pathophysiology, particularly the inflammatory response, remains crucial for improving patient outcomes. In this study, we investigated the presence of transmembrane pr...
Article
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Introducción: las enfermedades crónicas han aumentado a nivel mundial debido al estilo de vida y otros factores como el tabaquismo, el alcohol, la obesidad, la comida ultraprocesada baja en fibra, carente de frutas y verduras, etc. La evidencia científica respalda el uso de polifenoles dietarios como agentes preventivos y terapéuticos que podrían a...
Article
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Introdução: A hipertensão arterial é um dos principais fatores de risco para doenças cardiovasculares e está diretamente associada à remodelação cardíaca, um processo adaptativo que pode levar à disfunção miocárdica e insuficiência cardíaca. A hipertrofia do ventrículo esquerdo, o aumento da rigidez arterial e as alterações estruturais e funcionais...
Article
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O presente estudo tem por objetivo descrever sobre a relação da trissomia do cromossomo 21 com o desenvolvimento de otite média na população infantil. Trata-se de uma revisão narrativa da literatura, utilizando dados de trabalhos indexados nas bases de dados LILACS e MEDLINE, nos idiomas português, inglês e espanhol, publicados entre os anos de 200...
Preprint
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Arachidonate 5-lipoxygenase (ALOX5) is a key enzyme in the biosynthesis of leukotrienes, which are potent lipid mediators involved in inflammation, immune responses, and various pathological conditions. Dysregulation of ALOX5 has been implicated in diseases such as asthma, atherosclerosis, and cancer. This paper provides an in-depth review of ALOX5...
Preprint
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AAmine oxidase copper-containing 3 (AOC3), also known as vascular adhesion protein-1 (VAP-1), is an endothelial cell adhesion molecule and enzyme involved in leukocyte trafficking and oxidative deamination of primary amines. Recent research highlights its role in inflammatory diseases, metabolic disorders, and cancer progression. This paper provide...
Article
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The central nervous system (CNS) is immune-privileged by several immuno-modulators as interleukins (ILs). ILs are cytokines secreted by immune cells for cell-cell signaling communications and affect the functions of the CNS. ILs were reported to orchestrate different molecular and cellular mechanisms of both physiological and pathological events, t...
Preprint
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Iron deficiency (ID) is common in heart failure (HF) patients and associated with poorer outcomes. However, traditional markers like ferritin and transferrin saturation (TSAT) may fail to accurately assess ID due to the confounding effects of inflammation. In this study, we introduce the Adjusted Ferritin Inflammation Index (AFII), a composite scor...
Article
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In prostate cancer (PC), chronic inflammation silently guides disease progression, playing a significant role. As a major global health concern, PC contributes to high mortality rates and rising new cases worldwide, highlighting the urgent need for research into the molecular mechanisms behind this disease. Notably, the persistence of inflammation...
Article
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Background The prevalence of type 2 diabetes mellitus (T2DM) remains high and biomarkers related to T2DM are needed to be investigated. This study aimed to investigate the association between neutrophil percentage-to-albumin ratio (NPAR) with all-cause mortality and the risk of cardiovascular disease (CVD) mortality in community-dwelling individual...
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Background: Because Regnase-1, encoded by ZC3H12A, suppresses the development of pulmonary arterial hypertension (PAH) by controlling pro-inflammatory cytokines, we aimed to identify ZC3H12A variants in patients with PAH. Methods and Results: We analyzed whole-genome sequence data of patients with PAH to search for disease-associated ZC3H12A varian...
Preprint
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Inflammation triggers coagulation. Gestational Inflammation with its vascular implications is the cause of the major obstetric complications, from sporadic and recurrent miscarriage, to foetal growth restriction, premature delivery with all its nefarious perinatal sequels, up to the most dramatic scenarios of foetal and maternal death: it is neithe...
Article
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Background: SLIPPERS (Supratentorial Lymphocytic Inflammation with Parenchymal Perivascular Enhancement Responsive to Steroids) is a rare variant of a syndrome called CLIPPERS (Chronic Lymphocytic Inflammation with Ponsine Perivascular Enhancement Responsive to Steroids). SLIPPERS is characterized by distinct supratentorial lesions that share radio...
Article
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Background/Objectives: Evidence supports the benefits of concurrent training (CT), which combines endurance and resistance exercises, for enhancing health and physical fitness. Recently, low-volume, time-efficient exercise approaches such as low-volume high-intensity interval training (LOW-HIIT), whole-body electromyostimulation (WB-EMS), and singl...
Article
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Background The emerging evidence of the role of the glymphatic system (GS) in Alzheimer’s disease (AD) provides new opportunities for intervention from the earliest stages of the disease. The aim of the study is to evaluate the efficacy of GS in AD to identify new disease biomarkers. Methods We performed a two-stage proteomic study to evaluate the...
Article
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Background Heart failure (HF) is associated with systemic inflammation and hypercatabolic syndrome, impacting body metabolism. The advanced lung cancer inflammation index (ALI) is a novel inflammatory and nutritional biomarker. We aimed to investigate the prognostic role of ALI in patients with HF. Methods We comprehensively searched PubMed, WOS,...
Article
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El Instituto de Investigaciones en Comportamiento Alimentario y Nutrición (IICAN) ha mantenido un compromiso constante con el estudio del comportamiento alimentario. Este segundo número especial de Journal of Behavior and Feeding marca el cierre de los festejos por los XV años de CICAN – IICAN y refleja la diversidad de enfoques y contribuciones ge...
Article
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Atopic dermatitis (AD) is a chronic inflammatory skin disorder affecting approximately 20% of children and 10% of adults. While previous studies have linked AD to allergen exposure, disruption of the skin barrier, and Type 2 immune responses, the precise pathophysiology of AD remains elusive, significantly limiting the effectiveness of current trea...
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Extracellular vesicles (EVs) are taken up by most cells, however specific or preferential cell targeting remains a hurdle. This study aims to develop an EV that targets cells involved in inflammation, specifically those expressing intercellular adhesion molecule-1 (ICAM-1). To target these cells, we overexpress the ICAM-1 binding receptor “lymphocy...
Poster
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Inflammation is a typical physiological consequence of tissue injury, infection, and other factors that induce various pathological alterations. Cassia fistula, commonly known as the golden rain tree, is recognized for its potential medicinal properties, particularly its anti-inflammatory effects. This study aims to discover anti-inflammatory compo...
Article
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Breast Implant Illness (BII) is characterized by a cluster of systemic and local symptoms affecting a subset of women with silicone breast implants. While symptom improvement is frequently observed following implant removal, the underlying mechanisms remain poorly understood, and the absence of reliable biomarkers complicates clinical decision-maki...
Article
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Purpose To investigate whether in diabetic cataract (DC), FoxO1 regulates high glucose (HG)-induced activation of NLRC4/IL-6 inflammatory mediators in human lens epithelial cells (SRA01/04) via the JAK1/STAT1 pathway, leading to cataract formation. Methods Expression levels of FoxO1, inflammatory factor IL-6 and inflammatory vesicle NLRC4 were exa...
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Complete blood count indices and their ratios are associated with adverse clinical outcomes for many acute illnesses, but the mechanisms generating these associations are not fully understood. Recent identification of a consistent pattern of white blood cell and platelet count co-regulation during acute inflammatory recovery provides a potentially...
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La Organización Mundial de la Salud define a la hepatitis como la inflamación del hígado que puede ser el resultado de una variedad de causas, como el consumo excesivo de alcohol, autoinmune, drogas o toxinas. El presente proyecto investigativo tuvo como objetivo determinar la hepatitis y factores determinantes en pacientes del Instituto Ecuatorian...
Article
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With the approval of tolvaptan as the first specific medicine for the treatment of rapidly progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD), biomarker discovery has gained renewed interest as it is widely recognized that these will be crucial in clinical decision-making, serving as either prognostic or predictive tools. Since the ma...
Article
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Introdução: A gastrite autoimune (AIG) é uma doença crônica caracterizada pela destruição das células parietais das regiões do corpo e fundo do estômago. O padrão ouro para o diagnóstico da gastrite autoimune é o exame histológico. O objetivo do estudo foi revisar a literatura para discutir os achados histológicos utilizados atualmente no diagnósti...
Article
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ABSTRACT Objective: To evaluate the changes in the success of free-accessible ChatGPT-3.5, Copilot, and Gemini artificial intelligence chatbots in multiple choice questions in the field of ocular inflammation and uveitis depending on the language difference of the questions. Material and Methods: Thirty-six questions regarding ocular inflammation a...
Article
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Introdução: A Doença de Crohn (DC) é uma enfermidade inflamatória crônica que afeta o trato gastrointestinal (TGI), podendo acometer qualquer parte deste, embora a porção mais frequentemente atingida seja o íleo terminal e o cólon. Diferente da colite ulcerativa, que se limita ao intestino grosso e afeta apenas a camada superficial da mucosa, a DC...
Article
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A migrânea é uma cefaleia primária incapacitante, caracterizada por dores intensas e recorrentes, acompanhadas de náuseas, fotofobia e fonofobia. Sua causa é multifatorial, envolvendo alterações neurovasculares, disfunções mitocondriais e inflamação. Além do tratamento medicamentoso, o exercício físico tem se mostrado eficaz como intervenção comple...
Article
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Introducción: La disbiosis en niños con trastornos del espectro autista (TEA), puede inducir inflamación intestinal y alteraciones en la permeabilidad intestinal favoreciendo la presencia de manifestaciones gastrointestinales y neuroconductuales. Objetivo: Evaluar la relación que existe entre la disbiosis y los niveles fecales de zonulina y calprot...
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This letter discusses the research conducted by Abdel-Razeq et al , highlighting a significant association between Helicobacter pylori (H. pylori ) infection and metabolic dysfunction-associated steatohepatitis (MASH) in individuals with a prior history of H. pylori infection. Using a comprehensive patient database, the study establishes an indepen...
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Introdução: A Doença de Behçet (DB) é uma vasculite sistêmica crônica que pode afetar diversos órgãos, incluindo o trato gastrointestinal, onde causa lesões ulcerativas semelhantes às da Doença Inflamatória Intestinal (DII), como a Doença de Crohn (DC) e a Colite Ulcerativa (CU). A semelhança clínica entre essas condições, incluindo sintomas como d...
Article
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A otite média aguda (OMA) é uma das infecções mais comuns em crianças, caracterizada pela inflamação do ouvido médio. Este estudo revisou os avanços no manejo da OMA, destacando a eficácia da amoxicilina como tratamento de primeira linha, com taxas de sucesso terapêutico superiores a outros antibióticos de espectro amplo. Observou-se a relevância d...
Article
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Introdução: Os inibidores de SGLT2 surgiram como uma inovação no controle glicêmico no diabetes tipo 2, com benefícios adicionais na redução da pressão arterial, inflamação renal e proteção da função renal, estendendo suas indicações a doenças renais e metabólicas, incluindo em indivíduos sem diabetes. Método: A pesquisa envolveu uma revisão de art...
Article
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Bromelain, an enzyme gotten from pineapples has stirred interest for its ability to reduce muscular pains and slow down delayed onset muscles soreness (DOMS) which occurs after working out or while having exercising routines among athletes and physically active individuals. The purpose of this study was to assess the efficacy of bromelain in attenu...