Inclusion - Science topic

Prasad Trivedi :

Thank you,

Actually, I use the following molarity:

1: Tri@@ton 0.4% EDTA 1mM, Tris 50mM and Fresh DTT 1mM (3 Times)

2: deoxycholate 20mM , EDTA 25mM, Tris 50mM and Fresh DTT 1mM (3 Times)

3: PBS

4: Water

I use the same molarity and steps for some recombinant proteins in our lab.

During the washing steps, unlike other proteins, in this case, impurities are not removed or they are removed very little. I use E. coli DE3 strain to express all my proteins. The confusing thing for me is the host proteins (HCP).

Aren't they the same in all cases? if yes, why i can't remove them in this case like others?

Is it possible that something downstream caused this to happen?

Thanks a lot

What do you really mean when you say memory?

My memory is not the same as your memory, even if we share the exact same experience.

Whose memory is valid?

Dictators (faschists) will call for change, to go back to (the memories of) a past that never was. That is, an imagined shared memory that appears good, may in fact be bad. That is, some memories are false.

Minister hints at punishment with unprecedented letter to National Science Centre over project exploring the role of bondage and domination in the development of trans identities...

Define inclusionary and exclusionary criteria. First, define the population and the sample frame. Second, list factors which give the minimum criteria. Examine this article, which lists Patton's criteria, so you can select what kind of purposeful sampling strategies. [Purposive is sometimes used instead; you can also look into convenience sampling.]

The protein in 8M urea is most likely denatured. When the urea is removed quickly, the protein may aggregate and precipitate. This may be why your see a loss of protein.

The usual way to renature urea-denatured protein by dialysis is by a more gradual process, dialyzing against decreasing concentrations of urea in several steps. It is also helpful to keep the protein concentration as low as feasible to reduce aggregation.

It is unlikely that all of the protein will be recovered in soluble form even with the more gradual process, and some of the soluble protein that is recovered will probably be aggregated. The refolded, reconcentrated protein should be subjected to gel filtration chromatography or sucrose gradient centrifugation to purify the monomer (or physiologically relevant oligomer) from the aggregate.

Thanks to all

Generally inclusion bodies can be reduced by:

One theory that is often considered relevant for English Language Learners (ELLs) in an Algebra inclusion classroom is the Socio-Cultural Theory. This theory, developed by Russian psychologist Lev Vygotsky, emphasizes the role of social interaction and cultural context in cognitive development.

From the perspective of ELLs, the Socio-Cultural Theory suggests that positive impacts on their learning in the Algebra inclusion classroom can be achieved through:

1. Collaborative Learning: Encouraging opportunities for ELLs to work together with peers and engage in collaborative activities can promote language development, problem-solving skills, and understanding of mathematical concepts.

2. Scaffolding: Providing appropriate support and guidance to ELLs, such as visual aids, manipulatives, or simplified explanations, can help them grasp complex Algebraic concepts while simultaneously building their English language proficiency.

3. Cultural Relevance: Incorporating culturally relevant examples, contexts, and real-life applications within the Algebra curriculum can increase ELLs' engagement and motivation, as they can connect mathematical concepts to their own experiences and cultural backgrounds.

4. Language Support: Offering explicit language support strategies, such as vocabulary instruction, sentence frames, or explicit instruction in academic language, can help ELLs better comprehend and express mathematical ideas in English.

No offense to Brandon Thomas, but I would not use Hergenhahn. His book is too prone to errors. See attached article for a few examples and I could add others. Now, the attached is somewhat dated, but editions after he might have corrected some of the errors he had not done so. Also, I retired from teaching years ago, and the only textbook I have seen in recent years, which I do recommend, is Fancher and Rutherford's Pioneers in Psychology (5th Edition, 2017). Fancher (older male) is a long-established historian of psychology and Rutherford (younger female) is a rising star whose specialty is history and theory of psychology. I will close by saying I have many publications in HoP broadly defined to include behavioral neuroscience, and I taught gradate-level HoP for 18 years and at the undergraduate level, maybe, 5-7 times. All my publications, if anyone wants any, are listed at:

Email any requests or questions to rkthomas@uga.edu

It might be on Academia:

Including master's theses and doctoral dissertations in your systematic review can be a valuable addition to your search strategy. These sources often contain original and detailed research that may not have been published in peer-reviewed journals or other sources. However, there are some arguments against including theses and dissertations in a systematic review. Some of these arguments include:

Quality Control: Unlike published peer-reviewed articles, theses and dissertations are not subject to the same level of scrutiny and review.

Limited Access: Some theses and dissertations may not be easily accessible, which can limit their inclusion in your review.

Publication Bias: Theses and dissertations are often focused on a specific topic or research area, which may result in publication bias.

When deciding whether to include master's theses and/or doctoral dissertations in your systematic review, it is important to consider the quality and relevance of the sources. You may want to focus on including theses and dissertations that are relevant to your research question and meet certain quality criteria. It is recommended that you consult with your team and consult the guidelines of the specific journal or publication you plan to submit your systematic review to for guidelines on including theses and dissertations.

Ajit Singh If ArXiv does not allow papers that have already been published in a peer-reviewed journal to be uploaded to their website, why not only thousands of published papers are uploaded, why is there a "Journal Reference" and "DOI" option when uploading a paper, and where does ArXiv state that they dont allow published papers?

Spontaneous fracture of tempered glass due to nickel sulfide (NiS) inclusions is indeed a common issue. The phenomenon occurs as NiS undergoes a phase change from a high-temperature form (alpha-NiS) to a low-temperature form (beta-NiS), which causes an increase in volume and potentially induces enough stress to fracture the glass.

Now, regarding the fracture mirror: when a brittle material like glass fractures, it often produces certain characteristic features. These can include the mirror, mist, and hackle regions, which relate to the speed and direction of crack propagation. The mirror region, closest to the origin of the crack, is typically smooth and shiny, hence its name.

For NiS-induced fractures in tempered glass, a fracture mirror should theoretically be present around the NiS inclusion, which acts as the origin of the crack. However, it can indeed be very difficult to locate for several reasons:

Therefore, while a fracture mirror should be present in theory, it can often be very difficult to observe in practice. Methods like scanning electron microscopy (SEM) or other forms of microscopic analysis could potentially be used to locate and examine the fracture mirror if required.

Dear Harmeet Singh,

check out this analysis: https://www.spglobal.com/spdji/en/research/article/what-happened-to-the-index-effect-a-look-at-three-decades-of-sp-500-adds-and-drops/

Sincerely

Tomasz Miziolek

I think, Health education different with health promotion. Health promotion not only

The Global Sustainable Tourism Council (GSTC) Criteria: The GSTC Criteria serve as the global baseline for sustainability in travel and tourism. They are organized around four main themes: effective sustainability planning, maximizing social and economic benefits for the local community, enhancing cultural heritage, and reducing negative impacts on the environment.

Como modelo de lenguaje, no tengo una opinión personal sobre la inclusión laboral de las personas con diversidad funcional, pero puedo informarte sobre algunos hechos y tendencias.

En general, la inclusión laboral de las personas con diversidad funcional ha mejorado significativamente en muchos países en las últimas décadas, gracias a una mayor conciencia social y a la implementación de leyes y políticas que promueven la igualdad de oportunidades. Sin embargo, todavía hay muchos desafíos por enfrentar, como la falta de acceso a la educación y capacitación, la discriminación y estereotipos negativos, y las barreras arquitectónicas y de accesibilidad en el lugar

Considero que existen recursos de control, pero no los suficientes. Es obvio que faltan muchos recursos dentro de los servicios sociales y por ello no pueden garantizar su funcionalidad.

Freeze-thaw is not an efficient method of breaking the cells, although it may release some protein. You can also add EDTA to destabilize the outer membrane and lysozyme to destroy the peptidoglycan cell wall. Osmotic shock (e.g. distilled water) may then improve cell lysis. (see attached file)

Frothing during sonication should definitely be avoided. It does not cause the formation of inclusion bodies, but it does have the potential to denature the protein you are trying to isolate. Frothing can usually be prevented by keeping the power setting low enough and immersing the probe deeply enough. The sound you hear during sonication should be like that of food frying. If frothing occurs, stop immediately and let the air rise to the surface before continuing. Use multiple short bursts with cooling in between. Heating of the sample can be minimized by using a stainless steel beaker set in a mixture of ice and water, since steel is a much better heat conductor than glass or plastic.

If there is a French press available at your institution, it is a very effective way of breaking open E. coli cells for protein extraction without heating. I use two passes at 18,000 psi.

Another way to break the cells is with a bead beater, which is a relatively inexpensive piece of equipment. Preventing overheating of the sample is a problem with it, though.

There are also detergent-based reagents available that can be used to break open the cells, if you don't mind getting detergent in your sample. Because of the expense, the reagent is best used for small amounts of bacteria.

https://www.thermofisher.com/order/catalog/product/78243#:~:text=The%20B%2DPER%20Reagent%20solution,will%20leak%20out%20cytosolic%20proteins.

(6) Inclusiveness practices help to create a positive learning environment where all students feel valued, respected and supported.

(7) IPs promote diversity and respect for individual differences, preparing students to be inclusive and culturally aware in their future careers and personal lives.

(8) By including students with special needs in the general education setting, the general education students benefit from learning about diversity and acceptance, which helps to break down stereotypes and promotes understanding and empathy.

(9) Inclusiveness practices also help to reduce stigma and discrimination associated with special needs and disabilities.

(10) It enables students with special needs to participate in the same activities and educational opportunities as their peers, promoting their integration and full inclusion in society.

unfavorable monetary policy and weak regulatory framework have vacuum or gaps that this access of massive private credit mobilization to private sector hence exerbating financial inclusion index among others influencing factors

Ensuring the validity of the inclusion and exclusion criteria in a literature review is crucial for ensuring that the literature review is comprehensive, relevant and reliable. The following are some processes that can be implemented to ensure the validity of the inclusion and exclusion criteria:

By implementing these processes, you can ensure that the inclusion and exclusion criteria are applied consistently and objectively, and that the literature review is comprehensive, relevant, and reliable.

An interesting question indeed!

I observed that some of our friends here had already provide an intriguing response. Well, let me share my thought based on my own personal experience as a professional. I went to office everyday because I was paid to perform specific jobs (as per my job specifications). Without "financial inclusion" or if I was not paid for, I will never have any obligation to obey (to any empowerment directives or protocols).

In other words, you can empower everybody, whether male or female, by employing money (so-called "financial inclusion") as a tool to influence them to do something. Thanks.

Chip Akins

About your last post:

Plenum is real.

light is a particle with a structure (not a point or a wave)

Plenum (aether, spacetime, etc.) waves are longitudinal with only a very small and very limited transverse component.

matter warps plenum to emerge to gravity.

hods are magnets with N & S poles (hence no monopoles).

Only 1 field and 1 force (plenum gradient).

There once was a time where nothing existed, means that both plenum and hods are created and are the only 2 components of the universe. So, when models suggest the gradient produces a force such as Newton & GR, they ignore the origin of the plenum.

What is your origin story?

Scalar Theory of Everything (STOE) unites the big, the small, and the four forces (GUT) by extending Newton's model

Thank you deae Jack

To define debonding at the matrix-particle interface using the cohesive surface method in Abaqus, you can follow these steps:

Keep in mind that the cohesive surface method is just one approach to modeling debonding in particulate composites. Other methods, such as the cohesive element method, may also be used depending on the specific needs of your simulation.

Concerning your second question: Which "board" do you mean? However, authors should write their articles themselves. In science, ghostwriting (https://en.wikipedia.org/wiki/Ghostwriter) is regarded as misconduct.

Barbara Loi Omar Hernando Avila-Poveda (Avila-Poveda OH)

I just wanted to comment that I was having the same issue with liver samples crumbling (like sandstone) during sectioning and soaking the tissue blocks in water for the 30min - 1hr made a huge difference. The water seems to hydrate the tissue allowing it to stay in tact during sectioning. If it starts doing it again I plop back into the graduated cylinder with dH20 for a few mins. The tissue sample will protrude from the block some, so you may not want to leave it in water for too long because with the first pass of the blade you will lose some of your tissue. Thanks Omar! The animal tissue techniques that you cited is great. I will be referring back to it whenever I run into anymore issues!

Hi, I would love to study this topic too

No, you can't add two post-hoc analysis of the same trial in the same review, this is considered duplication of data. The reason behind different numbers for the same outcomes can be different populations, for example one post hoc investigation (drug x for hypertension) efficacy in patients with diabetes mellitus and the other post hoc in patients with chronic renal failure. There are other reasons for the different numbers, but in my perspective pooling two post hocs from the same trial is not valid unless the outcomes are different.

Shiva Shetty Hi. I have structurally modified curcumin (CUR) to its pyrazole (CP) form and then prepared inclusion complex (CPCD) of CP with HPBCD. CUR is a polyphenolic compound and hence checked the total phenolic content of the samples. Results demonstrated that CPCD had maximum polyphenolic content followed by CP and CUR. I need explanation for the obtained result. Thank You for your response.

Guidelines for the assessment of gender mainstreaming (fao.org)

Risk of bias assessment for case-series? (researchgate.net)

There are no active projects

policy is related with social and with out society there's no speak or space for the policy

Hello Alexander C. Anderson ,

My previous lab worked with a transmembrane protein and were able to purify the protein domains via denaturation using 6M GuHCl. We refolded, dialyzed, and concentrated the protein to visualize the purified and functional protein. Have you tried visualizing the protein after refolding and concentrating?

Also, for the full-length transmembrane protein, I used to heat the samples at about 80degC for 10 minutes rather than boiling the samples. I heated the protein in RIPA lysis buffer which helped.

Good luck,

Meera

"Prevalence" is the number of occurrences in the whole population studied. Individual rates could still be subdivided between arterial vs. venous, stenotic vs. thrombotic, whole organ vs. live donor, whatever so longas population size remains adequate for analysis. "Incidence" is the number of NEW events in a population under study. You might check with your institutions' statistician, but I believe incidence is not a retrospective descriptor. Looking back over time for vascular events will give you the PREVALENCE in the (sub)population studied. Finding associations explaining prevalence in your retrospective study (perhaps using analysis of variance) could lead to changes in operative strategy to reduce the incidence of that problem moving forward. For example: suppose the "prevalence" of arterial thrombosis was 5% overall, but 10% with a greater than 4mm diameter mismatch between donor and recipient. Changing surgical technique would hopefully reduce the "incidence" of this complication moving forward. But that's another study...

Cyclodextrins have both hydrophobic and hydrophilic character and are capable of encapsulating a hydrophobic drug molecule and forming guest-host complexes.

In medicine, cyclodextrins primarily act as a complexing vehicle and consequently serve as powerful drug delivery agents.

cyclodextrins are relatively easy to make. Starch is treated with a combination of common enzymes, notably cyclodextrin glycosyl transferase and α-amylase. Each enzyme combination produces a characteristic ratio of the three cyclodextrins.

I hope this answer will help you little bit ..

Have a good day.

In my opinion, "Inclusion" is a good term.

This term does not carry any negative or positive meaning.

The inclusion may be more rigid than the matrix, or vice versa.

"Inclusion" has many synonyms: particle, filler, etc.

Best regards

Usually, 3'UTR can contain regulatory elements (such as miRNA binding sites).I would avoid them if they are not neccessary. However, it should still work.

Double terminators have been shown to increase protein yield in plants and in mammalian cells as far as I remember.

Hello Sahil, based on what you just said the problem seems to be too many IVs for your number of observations . I understand that you would like to include industry effects but you don't have enough observations for that big a model. Therefore increased n or decreased number of predictors seems to be your options. Best wishes David Booth

No I don't

Hi Muhammad, I agree with Suraj's point and it sounds like you are investigating a cool topic. To broaden your search you could try data bases such CINAHL, Web of Science, and Medline. I found it extremely beneficial to consult with some librarians to assist in developing my search syntax (particularly as I found some subtle differences in the syntax as I searched between databases). This might help broaden your search.

Scopus updates Mars 2022 inclusions uses to facilitate academic publications while exclusion list support the academic level by reflecting achived researches

Hi, did you find a protocol for this? I am trying to do this same thing with my bacteria, so any insight would be really helpful.

Should I include the mole ratio on Y axis ?

I read some literatures that they plot it

abs* ratio vs ratio . But I did not get the same result as I plot it abs vs ratio .

There is global consensus on the importance of financial inclusion due to its vital role in bringing integrity and stability into an economy's financial system and its role in sustainably fighting poverty. However, it is more pertinent in the case of some African countries, such as Nigeria as a developing nation, to use financial inclusion as a platform not just for growing the financial sector but more as an engine for driving inclusive economic growth.

I think that you talk about visual elicitation interviews. You can use any object or visual product in the interviews. It can be something found, already available or documents that are elicited, provoked. You can use drawings, collages, legos or any other respondent-generated imagery or researcher-produced visuals.

Considero que todos los avances sociales son frutos de una alianza cuyo objetivo es garantizar la igualdad en macroorganizaciones como son las sociedades. A voz de pronto, podemos pensar en la aprobación del matrimonio igualitario en 32 países de todo el mundo (hasta marzo de 2022), aprobación que ha sido consecuencia de una serie de alianzas en cuanto a personas, colectivos, grupos políticos, etc.

Otra realidad puede ser el derecho a la eutanasia y a morir con dignidad, legalizada y garantizada en países como Países Bajos, Alemania, Tasmania, Canadá o España entre otros. Como hecho social, -estemos a favor o en contra-, ha sido fruto de una serie de uniones que han dado respuesta a una necesidad que, desde hace años, pacientes con enfermedades terminales estaban demandando.

Efectos negativos de alianzas, muchos, los más destacables son los conflictos armados como las guerras, ahora más en auge que nunca con la ofensiva de Rusia a Ucrania.

Hii... Keir.... I'm Mohammad H. Holle. Regarding the question of Financial Inclusion indicators, in the research I did, I used general indicators that are also used by the World Bank and the Indonesian Financial Services Authority. the indicators are: Access, Quality, and Usage. so my brother.

This link maybe useful

"JBI’s critical appraisal tools assist in assessing the trustworthiness, relevance and results of published papers"

Hello dear Peterson, I am interested in topic 3 and 7. Thank you.

Hi Seyed,

However, your provided information about your protein is not sufficient, but still, I could suggest a couple of things worth trying. Could you please tell let a bit more about the origin of protein, expression system, protein tag, expression condition, temperature, lysis method and buffer composition? If you have already tried and optimized everything at the expression level (for example low-temperature expression, solubility tag like MBP, GST, SUMO etc, overexpression in presence of ligand, metal ions etc..), you can try a range of detergents to solubilize the protein from inclusion bodies. Urea is a strong denaturating agent and causes the unfolding of the protein. Using a high concentration of chaotropic results in complete disruption of protein structure, so better to replace UREA with some detergent like NP-40, Sarcosin, triton X-100, twin20, DDM etc. You could use a combination of these detergents to solubilize the protein and remove them step by step in further purification steps.

The extreme pH buffer has also been reported as a mild solubilization method. High pH (>12) buffer in combination with 2 M urea has been used successfully for solubilization of IB.

Use low urea concentrations with detergents like N-Lauroylsarcosine and Lauroyl-L-glutamate have also been reported to improve the yield.

If nothing works with your protein and you end up with UREA, then try to remove UREA step by step by following various refolding protocols. For example, Multistep dialysis against a large volume of refolding buffer in the presence of low concentrations of AAs like arginine, proline, glycine etc. Sucrose, sorbitol solutions.

Best of luck,

Stata automatically eliminate it

With International Women’s Day upon us, the need for greater diversity in HE is under the spotlight. And the current requirement for potential STEM students to have studied traditionally related subjects such as maths and physics seems outdated and unnecessary...

It’s no secret that the ongoing lack of diversity in STEM industries causes significant problems. Recent studies have shown that companies with more female employees and with women in leadership positions financially outperform those that are less gender diverse...

Hi Cibeles Miralles,

Yes it is. Recently we have conducted a empirical study which covers 20,000 + meta-analyses, we emulate the situation that only 3 earliest studies available, 4 earilest, ...., 10 eaerlieest studies available, and compared the results to the full meta-analyses. We found that, in 81% of the situation, 3 studies can achieve the same conclusion to the full meta-analyses.

You may follow our paper, it will be online few weeks later.

Best regards

Chang

You can also consider qualitative research which is contextual. Multiple case studies or narratives can fit in. You can include participants who are able to articulate

Yes you can

Thank you Prof. Yosef Tadesse for your question. Yes, economic, social inclusion and good governance at the societal level are solutions for the global economic future, to which we associate the concept of collaborative economy!

Thank you all for your answers and I wish you a Merry Christmas and a Happy New Year 2022 full of personal and academic accomplishments with your loved ones!

Most likely, shaker speed won't affect the formation of inclusion bodies. The main effect will be on aeration, but at 18 °C, the growth rate will be slower and oxygen solubility will be higher than at 37 °C, so aeration is probably not a limiting factor. You may consider choosing a lower speed, though, to reduce the mechanical wear and tear of your shaker: 150 rpm should be OK for media such as LB or 2YT. You should also take care of choosing a culture vessel big enough so that the depth of liquid doesn't exceed 4-5 cm to get a good surface:volume ratio for optimal aeration. 1-L Fernbach flasks are a good option for culture volumes up to 700-800 ml.

Leadership develops leadership quality and they believe in work so it administrative power is stimulated by school and it role will continue to be life-long. I crossed that beautiful movement teaches more to me.

Attrition rates usually refer to participants who drop out of a longitudinal research project. Instead, it sounds like you have simple case of setting inclusion criteria and removing potential participants who did not meet those criteria.

Terzungwe Dugeri

Reviewers must recognize strengths and give constructive feedback to assist the author in resolving problems in the work. Some journals want two sets of remarks from reviewers: one for the author and one for the editor exclusively.

It is perfectly OK to disagree with a reviewer's opinion. You can write the editor a point-by-point rebuttal stating why you disagree with the reviewer's proposal. Make sure your response is supported by evidence. If your point of view is well-founded, the editor will take it into account.

Revise your contribution and explain why you didn't change some of the reviewers' remarks. Describe what you changed or did not alter and why in the cover letter and/or the 'Response to reviewers' document. You should withdraw your manuscript. Object to the editor's choice.

Isabelle, I know that this type of solution has been used in João Pessoa/PB known as "estacas de compactação": http://ct.ufpb.br/ccec/contents/documentos/tccs/2015.2/pratica-das-fundacoes-na-cidade-de-joao-pessoa.pdf

I suggest also that you contact companies like Tecnogeo and Brasfond. They probably can provide you with information about this type of solution.

One should follow PRISMA guidelines thoroughly for reporting any systematic review and meta analysis. Here, STROBE reporting guidelines are not required.

ROBINS-I tool is used for assessment of risk of bias of included study.

There is two tools for RoB assessment of observational studies. Robins-I (intervention) and Robins-E (exposure). Select as per the needs.

Then, Use Revman tool for synthesis of extracted data and and GRADE tool for certainty of evidance.

It isn't possible for a correctly specified interaction to significantly increase R^2 and have a non-significant interaction term in a general linear model. In a generalised linear model (as Bruce Weaver noted) R^2 isn't uniquely defined so I don't think you can have a significance test of the change in R^2. It is just about possible for the change in deviance for the model to be significant and the Wald test to be non-significant (but unlikely with large n). In these case the change in deviance using the likelihood ratio chi-square (the likelihood ratio test) is more accurate than the Wald test.

Stir the HPCD solution with your guest vigorously (e.g., ultra-turrax) or sonicate for some time, filter the insoluble, and freeze-dry the solution. You can record a solubility isotherm by this method using various HPßCD concentrations. Eventually, you can try more than one HPßCDs (different DS, Degree of Substitution, number of HP groups/macrocycle). It might be that higher DS (e.g., DS~6.3, which is a USA version of HPßCD) works better.

In the case of low DS (3.5-4.5), the amount of mono(2-hydroxy)propyl-ßCDs is noticeable, and they can form even less soluble complexes than the guest alone.

Please remember that in the case of very insoluble guests, the dilution of the complex solution with water may lead to hazy solutions or sometimes precipitation.

DMSO forms complexes with various CDs, and, additionally, it is practically impossible to remove from the complex.

ADD: OF COURSE !! All those that you consider appropriate for your research from a SOCIODEMOGRAPHIC POINT OF VIEW: Age, sex, type of profession, years of practice in it and a long etcetera (for example, if you wanted to study something related to Premenstrual Syndrome -PS_ it is obvious that you should only sample women of childbearing age, within your Target Population); This entails, as it goes without saying, that it also has to include EXCLUSION CRITERIA!

Thank you sir. I will find the book, and when the time is right, I will take you up on your offer. Your consideration is appreciated.

Robert

Yes. Exactly right. The financial technologys are used to boost the financial health of the economy of any country.

Hi Nirmal, How are you getting on with this systematic review? Did you include case studies and case control studies?

I can imagine there would be quite a mixture of literature types on your topic.

This may be helpful.

It appears that 2 variables contain the same information. I'm attaching a recently accepted paper of ours that had a similar problem and tells how we dealt with it. Best wishes, David Booth