Science topic

Immunity - Science topic

Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.
Filters
All publications are displayed by default. Use this filter to view only publications with full-texts.
Publications related to Immunity (10,000)
Sorted by most recent
Article
Full-text available
تعد المناعة التنظيمية إحدي الأدوات الإستراتيجية التي تمكّن الشركات من الوصول إلى التميز والتفوق على المنافسين، ومن ثم تعزيز السمعة التنظيمية. ولقد استهدفت الدراسة الحالية التعرف على أثر المناعة التنظيمية بأبعادها الثلاثة المتمثلة في التعلم التنظيمي، والذاكرة التنظيمية والجينات التنظيمية على السمعة التنظيمية بشركات الطيران، كما هدفت الدراسة إلي تحدي...
Article
Full-text available
Background Efforts toward the development of an effective vaccine against Acinetobacter baumannii , one of the most notorious nosocomial pathogens, are still ongoing. In this regard, virulence factors are interesting targets. Type VI secretion system (T6SS) participates in the pathogenicity of A. baumannii . VgrG is a crucial component of T6SS prev...
Article
Full-text available
Background Autoimmune encephalitis (AE) is a type of encephalopathy mediated by an antigenic immune response in the central nervous system. Most research related to autoimmune encephalitis (AE) is focused on early diagnosis, treatment and prognosis analysis; there has been little research conducted on the characteristics of immune function, and the...
Article
Full-text available
Background DNA methylation is an epigenetic mark that is influenced by underlying genetic profile, environment, and ageing. In addition to X-linked DNA methylation, sex-specific methylation patterns are widespread across autosomal chromosomes and can be present from birth or arise over time. In individuals where gender identity and sex assigned at...
Article
Full-text available
The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a key player in pathogenic ocular neovascularization almost a decade ago. Since then, an increasing number of publications have reported the involvement of LRG1 in multiple human conditions including cancer, diabetes, cardiovascular disease, neurological disease...
Article
Full-text available
Inflammatory bowel disease (IBD) is a chronic recurrent inflammatory disease of the intestine, including Crohn’s disease (CD) and ulcerative colitis (UC), whose etiology and pathogenesis have not been fully understood. Due to its prolonged course and chronic recurrence, IBD imposes a heavy economic burden and psychological stress on patients. Tradi...
Article
Full-text available
Background: Population-level SARS-CoV-2 immunological protection is poorly understood but can guide vaccination and non-pharmaceutical intervention priorities. Our objective was to characterise cumulative infections and immunological protection in the Dominican Republic. Methods: Household members ≥5 years were enrolled in a three-stage national...
Article
Full-text available
Background The association between autophagy and immunity, including infiltrating immunocytes, immune reaction gene-sets, and HLAs (human leukocyte antigen) gene, remains unclear. The present study aimed to provide a valid diagnostic tool for coronary artery disease (CAD), and explore the pathological mechanisms of CAD based on the association betw...
Article
Full-text available
Immunity in plants arises from defense regulatory circuits that can be conceptualized as modules. Both the types (and isolates) of pathogen and the repertoire of plant receptors may cause different modules to be activated and affect the magnitude of activation. Two major defense enzymes of Arabidopsis are ALD1 and ICS1/SID2. ALD1 is an aminotransfe...
Article
Full-text available
Although pediatric populations experienced lower COVID-19 severity and mortality than adults, the epidemiology of this disease continues to evolve. COVID-19 clinical manifestations in pediatrics commonly include fever and cough, but may differ from adults and by variant. Serious complications, including MIS-C, rarely occur. Although early data show...
Article
Full-text available
This paper reports the results of a public engagement study on heritable human genome editing (HHGE) carried out in South Africa, which was conducted in accordance with a study protocol that was published in this journal in 2021. This study is novel as it is the first public engagement study on HHGE in Africa. It used a deliberative public engageme...
Article
Full-text available
Schizophrenia is a psychiatric disorder with significant impact on individuals and society. The current pharmacologic treatment, which principally alleviates psychosis, is focused on neurotransmitters modulation, relying on drugs with severe side effects and ineffectiveness in a significant percentage of cases. Therefore, and due to difficulties in...
Article
Full-text available
The major economic and health consequences of COVID-19 called for various protective measures and mass vaccination campaigns. A previsional model was used to predict the future impacts of various measure combinations on COVID-19 mortality over a 400-day period in France. Calibrated on previous national hospitalization and mortality data, an agent-b...
Article
Full-text available
The immune system deploys a complex network of cells and signaling pathways to protect host integrity against exogenous threats, including measles virus (MeV). However, throughout its evolutionary path, MeV developed various mechanisms to disrupt and evade immune responses. Despite an available vaccine, MeV remains an important re-emerging pathogen...
Article
Full-text available
In this essay I will discuss Donna J. Haraway’s notion of sympoiesis and examine different modes of cohabitation or hybridization with nonhuman others. Such concepts as sympoiesis, or holobiont, question the notion of the biological individual and also change our understanding of what it means to be human. As Richard Grusin pointed out, “we have ne...
Poster
Full-text available
Developing Mental Health through monthly workshop. Panic attack rapidly increase in the modern world. Therefore people's need to relief the mental stress day today life.
Article
Full-text available
Macrophages are one of the essential components of the tumour microenvironment (TME) of many cancers and show complex heterogeneity and functions. More recent research has been focusing on the characterisation of tumour-associated macrophages (TAMs). Previously, our study demonstrated that caerin 1.1/1.9 peptides significantly improve the therapeut...
Article
Full-text available
Small antibacterial effectors, including lysozymes, lectins, and antimicrobial peptides, are key regulators of intestinal immunity. However, whether there is coordination among them during regulation is an interesting, but largely unknown, issue. In the present study, we revealed that small effectors synergistically regulate peptidoglycan-derived i...
Article
Full-text available
Agonists of trained immunity induce epigenetic changes in hematopoietic stem and progenitor cells (HSPCs) to generate long-lasting immune protection. Although trained HSPCs generate myeloid cells with increased responsiveness to secondary challenges, whether their differentiation kinetics is affected by prior exposure to inducers of trained immunit...
Article
Full-text available
Treating immunosuppressive tumors represents a major challenge in cancer therapies. Activation of STING signaling has shown remarkable potential to invigorate the immunologically “cold” tumor microenvironment (TME). However, we have shown that STING is silenced in many human cancers, including pancreatic ductal adenocarcinoma (PDAC) and Merkel cell...
Article
Full-text available
Immunity is the cornerstone of the strenthening performance of the body health system. the immune system is the defense system of the body against any pathogens. Regulation of the immune system through the sympathetic and parasympathetic arms of The autonomic nervous system. Allergic reaction is an inappropriate immune response to antigen. Allergy...
Article
Full-text available
Passive immunity transfer has a pivotal role in newborn lambs, where the colostrum represents the primary source of immunoglobulins. This study hypothesized that the high content in polyphenolic compounds, mono- and poly-unsaturated fatty acids, and vitamin E of hazelnut skin affects blood and colostrum immunoglobulin G (IgG) concentration and rela...
Article
Full-text available
Introdução: A síndrome hemofagocítica decorre da hiperatividade de histiócitos e linfócitos e é desencadeada por infeções, principalmente virais por citomegalovírus, Epstein-barr e herpes. A anemia de Fanconi (AF) é uma doença genética rara com sintomas heterogêneos em comun a outras doenças como a associação VACTERL, uma doença de etiologia descon...
Article
Full-text available
Studies have reported several cases with respiratory viruses coinfection in hospitalized patients. Influenza A virus (IAV) mimics the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) with respect to seasonal occurrence, transmission routes, clinical manifestations and related immune responses. The present paper aimed to develop and inve...
Article
Full-text available
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). One of the main topics of conversation in these past months in the world of immunology has been the issue of how patients with immune defects will fare if they contract this infection. To date there has been l...
Article
Full-text available
Introdução: Em janeiro de 2020, a OMS declarou o novo coronavírus como emergência de saúde pública de interesse internacional, sendo mais a frente declarada como sendo uma pandemia. Como estratégia para o enfrentamento e proteção de pessoas susceptíveis, a vacinação foi adotada como a forma mais eficaz de prevenção, além da produção de imunidade du...
Article
Full-text available
Revista Cubana de Información en Ciencias de la Salud. 2022;33:e2005 ………………Esta obra está bajo una licencia: https://creativecomons.org/licenses/by-nc/4.0/deed.es_ES Artículo original Análisis y desarrollo de una solución tecnológica basada en el estándar HL7 V3 para el acceso ubicuo al control de la vacunación Analysis and development of a technol...
Article
Full-text available
Both preclinical and clinical studies have demonstrated that the modulation of gut microbiota could be a promising strategy for enhancing antitumor immune responses and reducing resistance to immunotherapy in cancer. Various mechanisms, including activation of pattern recognition receptors, gut commensals-produced metabolites and antigen mimicry, h...
Article
Full-text available
FERONIA (FER) is a member of the Catharanthus roseus receptor-like kinase 1-like (CrRLK1L) protein subfamily, which participates in reproduction, abiotic stress, biotic stress, cell growth, hormone response, and other molecular mechanisms of plants. However, the mechanism by which a single RLK is capable of mediating multiple signals and activating...
Article
Full-text available
Helicobacter pylori is a major cause of gastric mucosal inflammation, peptic ulcers, and gastric cancer. Emerging antimicrobial-resistant H. pylori has hampered the effective eradication of frequent chronic infections. Moreover, a safe vaccine is highly demanded due to the absence of effective vaccines against H. pylori . In this study, we employed...
Article
Full-text available
In the last decade, a major dogma in the field of immunology has been called into question by the identification of a cell autonomous innate immune memory. This innate immune memory (also named trained immunity) was found to be mostly carried by innate immune cells and to be characterized by an exacerbated inflammatory response with a heightened ex...
Article
Full-text available
The immune tumor microenvironment (TME) of epithelial ovarian cancer (EOC) carries both effector and suppressive functions. To define immune correlates of chemotherapy-induced tumor involution, we performed longitudinal evaluation of biomarker expression on serial biological specimens collected during intraperitoneal (IP) platinum-based chemotherap...
Article
Full-text available
Objetivo: Traçar o perfil epidemiológico dos indivíduos vacinados no ano de 2021 no município de Jaraguá do Sul, SC. Métodos: Trata-se de um estudo transversal com abordagem quantitativa. A população foi composta pelos indivíduos vacinados contra o coronavírus, cadastrados no sistema de informação da Secretaria de Saúde do município de Jaraguá do S...
Article
Full-text available
The world is now apparently at the last/recovery stage of the COVID-19 pandemic, starting from 29 December 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the progression of time, several mutations have taken place in the original SARS-CoV-2 Wuhan strain, which have generated variants of concern (VOC). Therefo...
Article
Full-text available
A leptospirose é uma zoonose distribuída mundialmente. Leptospira sp. são espiroquetas patogênicas que colonizam os túbulos renais de animais, sendo eliminadas para o ambiente através da urina, permanecendo viáveis.3 São capazes de invadir tecidos por meio da pele ou mucosas, e se disseminar e replicar em tecidos e órgãos.4 Também estimulam a aderê...
Article
Full-text available
“Humanisation” has had a variable impact on international law. Nevertheless, it has failed to significantly affect the state-centric paradigm underpinning state and state officials’ jurisdictional immunities. The present contribution is intended to provide some remarks on the challenges and perspectives on the humanisation of international immuniti...
Article
Full-text available
Multiple vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been evaluated in clinical trials. However, trials addressing the immune response in the pediatric population are scarce. The inactivated vaccine CoronaVac has been shown to be safe and immunogenic in a phase 1/2 clinical trial in a pediatric cohort in China...
Article
Full-text available
Abstract Background Low-density Plasmodium falciparum infections prevail in low transmission settings, where immunity is expected to be minimal, suggesting an immune-independent effect on parasite densities. We aimed to describe parasite densities in pregnancy, and determine how gravidity and antibody-mediated immunity affect these, during a period...
Article
Full-text available
Purpose Biallelic loss-of-function variants in IKBKB cause severe combined immunodeficiency. We describe a case of autoimmunity and autoinflammation in a male infant with a heterozygous gain-of-function (GOF) IKBKB variant. Methods Case report and review of the literature. We performed in silico variant analysis, measurement of plasma soluble biom...
Article
Full-text available
Although parental vaccines offer long-term protection against homologous strains, they rely exclusively on adaptive immune memory to produce neutralizing antibodies that are ineffective against emerging viral variants. Growing evidence highlights the multifaceted functions of trained immunity to elicit a rapid and enhanced innate response against u...
Article
Full-text available
The advent and distribution of vaccines against SARS-CoV-2 in late 2020 was thought to represent an effective means to control the ongoing COVID-19 pandemic. This optimistic expectation was dashed by the omicron waves that emerged over the winter of 2021/2020 even in countries that had managed to vaccinate a large fraction of their populations, rai...
Article
Full-text available
Purpose Little is known about vaccine safety in inborn errors of immunity (IEI) patients during the current vaccination campaign for COVID-19. To better investigate the reactogenicity and adverse event profile after two, three, and four doses of mRNA vaccines, we conducted an observational, multicentric study on 342 PID patients from four Italian R...
Poster
Full-text available
Inspired by the experience of COVID 19 global pandemic, the international conference "CommUnity & ImmUnity" seeks to raise the following questions: How do “immUnity” and “commUnity” unveil themselves when we probe into the workings of identity? What connections, and by extension, which values have societies adopted to wrestle with the restrictions...
Article
Full-text available
Background: Immune system disorders are one of the main problems in end-stage renal disease (ESRD) patients undergoing hemodialysis. The weakening of the immune system in these patients makes them susceptible to various infections. Objectives: This research was conducted for the first time to investigate the prevalence of naturally acquired immunit...
Article
Full-text available
Objetivo: Discutir sobre o impacto do consumo de alimentos ultraprocessados à saúde infantil em tempos de pandemia da COVID-19. Metodologia: Revisão narrativa da literatura realizada por meio de busca bibliográfica de artigos em inglês e português, disponíveis nas bases de dados: Scielo, Biblioteca Virtual de Saúde (BVS), Google acadêmico e PubMed....
Article
Full-text available
As the SARS-CoV-2 pandemic evolves, vaccine evaluation needs to include consideration of both durability and cross-reactivity. This report expands on previously reported results from a Phase 1 trial of an AS03-adjuvanted, plant-based coronavirus-like particle (CoVLP) displaying the spike (S) glycoprotein of the ancestral SARS-CoV-2 virus in healthy...
Article
Full-text available
The keratinase-producing microbes can readily change the feather waste into more bioavailable peptides and amino acids. This study aimed to improve two-stage fermented feather meal-soybean meal product (TSFP) quality with five selected Bacillus strains and Saccharomyces cerevisiae Y10, as well as investigate the effects of TSFP on growth performanc...
Article
Full-text available
The radiated immunity of passenger cars and commercial vehicles is validated using electromagnetic interference from off-vehicle radiation sources in an anechoic chamber according to the procedure in ISO 11451-2. Common electrical or electronic vehicle systems, including dual flash, monitors, and entertainment systems, must be validated using a sta...
Article
Full-text available
In August 2021, a major wave of the SARS-CoV-2 Delta variant erupted in the highly vaccinated population of Israel. The transmission advantage of the Delta variant enabled it to replace the Alpha variant in approximately two months. The outbreak led to an unexpectedly large proportion of breakthrough infections (BTI)–a phenomenon that received worl...
Article
Full-text available
The maternal cells transferred into the fetus during gestation persist long after birth in the progeny. These maternal cells have been hypothesized to promote the maturation of the fetal immune system in utero but there are still significant gaps in our knowledge of their potential roles after birth. To provide insights into these maternal cells’ p...
Article
Full-text available
Cancer immunotherapies have changed the landscape of cancer management and improved the standard treatment protocols used in multiple tumors. This has led to significant improvements in progression-free survival and overall survival rates. In this review article, we provide an insight into the major immunotherapeutic methods that are currently unde...
Article
Full-text available
RESUMEN Introducción: el día 26 de abril del año 2022, en México se anunció el final de la pandemia y el inicio de la fase endémica, ya que se cumplía con los criterios para considerar dicha transición, pero lo cierto es que existía la posibilidad de la aparición de nuevas olas de COVID-19 por nuevas variantes, esto provocado por factores como la m...
Article
Full-text available
The pandemic of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has posed great threat to the world in many aspects. There is an urgent requirement for an effective preventive vaccine. The receptor binding domain (RBD), located on the spike (S) gene, is responsible for binding to the angiotensin-converting enzyme 2 (ACE2) rec...
Chapter
Full-text available
mmün sistem (bağışıklık sistemi) organizmada yabancı olanı tanıma ve hafızaya al-dığı bu yabancı antijeni tekrar gördüğünde daha hızlı olarak yok etme yeteneğine sahip olan sistemdir. Yaşam sürecinde oluşan kanser hücrelerinden bu mekanizma ile korunulur. İmmün sistemi oluşturan organlar santral (merkezi) lenfoid organlar olan kemik iliği, timüs il...
Article
Full-text available
Este estudo tem como objetivo demonstrar a ocorrência de larvas de parasitos em locais onde há maior número de crianças. As amostras de solo foram coletadas e levadas para o laboratório da Universidade Estadual da Paraíba e lá foi a abordada a técnica de Hoffman, Pons e Janer ou Lutz, ou método de sedimentação espontânea que consiste basicamente na...
Presentation
Full-text available
O Coeficiente de Onda Estacionária ou VSWR é um parâmetro importante na caracterização de uma célula TEM e seu limite usualmente é dado em norma, uma vez que ele tem influência na adequação da célula para realização de testes preliminares de imunidade a campos elétricos. Este trabalho apresenta a construção de uma célula TEM e a melhoria obtida no...
Article
Full-text available
Background: Knowledge about protection conferred by previous Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and/or vaccination against emerging viral variants allows clinicians, epidemiologists, and health authorities to predict and reduce the future Coronavirus Disease 2019 (COVID-19) burden. We investigated the risk and s...
Article
Full-text available
O Coeficiente de Onda Estacionária ou VSWR é um parâmetro importante na caracterização de uma célula TEM e seu limite usualmente é dado em norma, uma vez que ele tem influência na adequação da célula para realização de testes preliminares de imunidade a campos elétricos. Este trabalho apresenta a construção de uma célula TEM e a melhoria obtida no...
Article
Full-text available
Clear cell renal cell carcinoma is a common malignant tumor of the urinary system. The mechanism of its occurrence and development is unknown, and there is currently few effective comprehensive predictive markers for prognosis and treatment response. With the discovery of a new cell death process – cuproptosis drew the attention of researchers. We...
Article
Full-text available
Chronic arsenic poisoning is a global health problem that affects millions of people, and studies have found that long-term ingestion of arsenic-containing compounds can lead to lung damage, but the exact mechanism is unknown. In this study, Sprague–Dawley (SD) rats were used as the research object, and the proteomic analysis method based on sequen...