Questions related to Hyperthermia
My project is hyperthermic treatment of cancer using biomedical antenna, for that I am using a 4x4 patch antenna array design and a spherical homogenous glandular tissue with a tumor inside it. By giving appropriate phase and amplitude input I am able to heat the tumor at a temperature of 41.935'C but the input power is 36 W for a single antenna!!!. I am feeding all antenna's individually so the thing is power input is not at all practical input. I request you to give your suggestion on how to reduce the power input without affecting the temperature distribution.
My project is hyperthermic treatment of cancer using biomedical antenna. I have successfully managed to show max SAR and max temperature distribution at the tumor location inside the homogeneous breast phantom. Now my professor asked me to solve the pennes bio-heat equation and the power density relation to back prove if i am getting that temperature value. I am finding difficulty doing this can you share Matlab code or doc reference to do so. I have values of thermal conductivity, blood perfusion coefficient etc but these values are digits whereas temperature distribution is a 3-D quantity.
Electrical circuits for different experiments e.g Brownian motion, Hystesis Law and etc
Under the pandemic of COVID-19, screening becomes important to tackle the spread. Fever is one of the screening criteria for many public places screening for access.
However, how is fever defined?
Is the 0.1 degree change makes the significance?
What is the range of standard deviation being acceptable?
What machine is accurate?
Is those hand held infrared measuring machines reliable?
Is there scenarios giving false negative tha may make a huge consequence?
Normal Body Temperature: A Systematic Review.
Open Forum Infect Dis. 2019;6(4):ofz032. Published 2019 Apr 9.
I have synthesized some Iron oxide nanoparticles (powder sample). I have checked it's response with strong neodymium magnet in lab. Now I want to check its temperature response with time.
So I want to know how much amount of sample (maximum and minimum ) would be needed for this measurement ? In some literature they reported 1mg/ml and in others 5,10, 20...50 mg/ml also ? So I am confused whether I should use low concentrations or high one. ?
Page 7 line 17 In the present experiment, bimetallic alloy nanoparticles produced and a single surface plasmon resonance (SPS) peak of intensity of 409 nm is observed, and probe of identification of Ag/Co alloy, which is very close to the SPR peak at 410 nm of Ag/Co alloy synthesized by chemical reaction process .
Line 17. You are speaking about SPS. But because the research is focused on the nanoparticles they have Localise Surface Plasmon Resonance (LSPS).
Why did you used the wavelength 808 nm? Because the absorption caused by LSPR is around 400 nm (Figure 5) and at 808 nm the absorption due to plasmon resonance is negligible!
The possible reason for the higher temperature profiles and rise of nanofluid than water alone is the plasmonic hyperthermia effect of nanoparticles.
Line 57- "The possible reason for the higher temperature profiles and rise of nanofluid than water alone is the plasmonic hyperthermia effect of nanoparticles." The plasmonic behaviour is significant at around 400 nm. At wavelength 808 nm the absorption caused by Localised Surface Plasmon resonance (LSPR) are unneglectable. This discrepancies has to be explain in the text and in the Conclusion.
What is the similarities and differences of these 3 terms in biomedical sciences. if there is more, please add it here to make more complex question with a wholistic idea!
Hyperthermia therapy , Photodynamic therapy and Photothermal therapy
Thanks for your response in advance.
What kind of magnetic nanoparticles we can use for hyperthermia study? Can we use Manganese chalcogenide systems (MnS, MnSe) for hyperthermia treatment?
hyperthermia is the technique that neglects the use of chemicals or harmful radiations. The elevated body temperature can damage the cancerous cells.
I am actually using antenna radiation for hyperthermia treatment for treating the breast cancer. How could one simulate the temperature distribution inside the breast phantom using CST software?
I know the theory behind it by combinning the SAR values and the bioheat equation. However, I do not know until now how to accomplish it by simulation.
I have not had any luck finding studies related to hyperthermia testing on collagen 3D models. Is there any specific reason why collagen matrices are not being used for hyperthermia testing?
The amount of heat generated by SPIONs under external magnetic field is denoted as the specific absorption rate (SAR). SAR is the radio frequency electromagnetic field absorbed per unit of mass of biological tissue and is expressed in watts per kilogram (W/kg).
SAR is described in 2 ways in different literatures:
2) SAR (w/g)= c. ΔT/Δt
Which one of these equations are the right one for SAR measuermetnts? how we can have 2 equation for a single physical parameter ??
All the best
I want to simulate temperature distribution and acoustic wave propagation during High-Intensity Focused Ultrasound Hyperthermia in a 3-Dimensional model by using Comsol Software.
I did the simulation based on examples I saw in the Comsol but the results were not correct.
In fact, Acoustic Pressure Field is occured in Transducer surface that is not true.
If anyone can help me, I will appreciate him/her so much.
I am Dr. P. Prameela from Veltech University, Chennai, India. We have been developing nanoferrite materials for core applications. Recently we have extended our research area into materials for magetic hyperthermia.
In this regard, after going through your paper, I am requesting you to help us in taking the frequency dispersion of permeability of our samples using network analyzer. Let me also know how we can measure the real & imaginary parts of the permeability & how the sample holder will be at higher frequency (2 -18 GHz).
How to calculate the unavoidable exergy destruction of demethanizer and deethanizer in the attached figure? Some paper said using minimun reflux ratio to calculate unvoidable exergy destruction of columns, but I find it impossible used it in complex demethanizer and deethanizer because infinite stages cannot be achieved in simulation. So I think wether it is right that I just increase the theoretical stages to a certain value and I define it as unavoidable condition.
I would like to know how it is possible to heat at 42ºC during one hour the brain of mice (thermal therapy) in an easy way.
Thank you in advance for your advice.
I am reviewing Fluoride Death Data including the excess deaths attributable to Fluoride Toxicity, including but not limited to: Alzheimer’s, Anaesthetic Hyperthermia, Aortic Rupture, Asthma, Cancer, Cataract, Chronic Kidney Disease (including Pyelonephritis), Chronic Obstructive Pulmonary Disease, Crime (including Fluoride enhanced Plumbosolvency leading to elevated Blood Lead Levels), Diabetes, Fluoridation overdosing, Eclampsia, Foetal and Perinatal mortality, Gels, Rinses and Toothpastes, Hip Fracture, Liver Failure (including Fat Burner and Tea products), Stroke, Sudden Infant Death Syndrome, Suicide. I have already found many references but would like assistance in building a comprehensive bibliography.
heat acclimatization can increase performance of athlete and occupational for physical activity in heat condition.
for this purpose we have to train for adaptation in heat condition regularly. but I have some question about chronic heat stress.
does living in heat climate can lead to chronic fatigue?
does hyperthermia and heat illness occur without any symptom chronically?
I am a physician specialized in Clinical Environmental Medicine using Mild Whole Body Hypertermia to treat people suffering from chronic complex environment associated multisystem illnesses.
As in modern age, magnetic nano-particles (particularly iron oxides) are under extensive research for their possible applications in hyperthermia, Drug Delivery, etc .
I will be thankful for your comments/suggestions to clear my understanding about the effect of size variation of Magnetic nanoparticles on the amount of heat generated. If we use Np's e.g Fe3O4 of spherical shape and apply same AC magnetic field, but just vary the size of NP's used in different experiments.
How much will it effect the amount of heat generated ?
My study state is hyperthermia and i make a field monitor 3000 sec but when i changed it to 9000 sec,the temperature still the same.what is my fault??
I have seen some articles about tumor cell's high temperature and lower PH, I am wondering that if tumor cell has better resistance which means that tumor cell has lower temperature when heated by laser or microwave, or not? I cannot find any papers about this, what i can find are all about Hyperthermia. my email is: email@example.com for better communication. Thanks.
i want to check any synergistic or additive effect but my two indicators are not two drugs rather drug is applied with hyperthermia to enhance the apoptosis. so in this case can i apply isobolograph to check the synergistic effects or not? please guide me in this respect..
I have many difficulties in finding electro-thermal parameters of styrofoam (polystyrene) and laboratory glass (polypropylene)? In literature the authors rather have not mentioned which parameters they used in numerical simulations. I am especially interested in such parameters:
Electrical Conductivity [S/m]
Specific Heat [J/(kg K)]
Thermal Conductivity [W/(m K)]
for frequencies in the range of 100 kHz - 1000 kHz.
Maybe do you know the publications with such parameters?
I will be grateful for your help!
I am considering possibilities of hyperthermia like scenario to destroy cancerous tissues inside a human body using a swallowed pill. I am conserving solid-state devices like Gunn diodes or RTDs to generate local RF heating to achieve my goals. Your comments and guidance to existing technologies would be valuable. Thank you.
In the literature, I have found two different formulas for Neel relaxation time, namely:
tal_N = tal0*exp (K*VM/(kB*T)) (1)
tal_N = tal0/2*sqrt ((pi*kB*T)/(K*VM))*exp(K*VM/(kB*T)) (2)
For the same parameters I received about 3.6 times larger times for model (1)
Do You know which model is proper for magnetic fluid hyperthermia and when they are used?
I will be grateful for your help!
In both conditions, we know that duration and core body temperature affects the mortality. I am trying to understand/ find papers that have estimated the amount of time a patient can survive the low or high body temperature. For example, in children locked in vehicles an average of 4.6 hours results in death of the child. Does anyone know the limits of survival in both conditions? Is there any Paper/Book I could refer? Thanks
A lot many reports have emerged in the recent past investigating non-invasive RF hyperthermia using nanoparticles for cancer treatment. What are the presumed advantages of capacitive RF hyperthermia over inductive RF hyperthermia or vice versa? Since capacitive RF hyperthermia can cause heating up of ions, would its use on the body produce undesirable heating effects unlike inductive hyperthermia?
I would like to demonstrate a non-specific, general immune-system activation of mild hyperthermia treatment on normal, healthy mouse.
Can anybody suggest me a very simple method to measure this effect? I am open for any idea... (For example change of the leukocyte population in peripheral blood, appearance of some cytokine, etc.)
Thanks in advance!
The setup is isoflurane with passive scavenging through an activated charcoal filter. These mice are Parvalbumin Cre (+) and (-). Mice are placed on a heating pad throughout surgery. There also is a lamp about a foot and a half above the surgery table that can get pretty hot. I'm not sure if this is the problem though. The mice have no problem going down. Their breathing is normal up until about an hour to an hour and a half. Their breathing becomes labored, they start pooping, and their muscles become rigid. Although their breathing gets lighter, they do not respond to a tail or toe pinch reflex. After about 5-10 minutes of this labored breathing, they die. The isoflurane level is between 0.5 and 2 during surgery.
Do you think it is a problem with the isoflurane chamber, hyperthermia, buildup up isoflurane waste, or something else? Any help would be greatly appreciated. I have attached a video of the labored breathing with the mouse not responding to a touch pinch.
Interested in heat-labile linkers or thermo-responsive biocompatible polymers for hyperthermia cancer treatment application.
Hello, I'm currently working in magnetic hyperthermia related topic. Is it possible to achieve temperature rise if I put iron oxide magnetic particles in a RF coil of 1.5 T MRI (64 MHz) for 5 minutes? Will the particles vibrate and heat up? The particle has superparamagnetic properties (15 emu/gr). Thanks.
Common non invasive methods use blankets or ice, cold water immersion would be probably faster, but current guidelines for therapeutic hypothermia do not consider it.
Could cold water immersion be useful for other than heat stroke and hyperthermia treatment?
I want to work on targeted delivery of magnetic nanosystem on cancer cell for hyperthermia application. From prior art search, I found that surface receptor and antibody targeted delivery are the ways to deliver nanoparticles to the cancerous cell. Can we identify cancer cells from normal cells with the help of plasma membrane pore size? Can you suggest any new way for targeted delivery of nanoparticles to cancerous cells?
I am performing magnetic hyperthermia experiments with iron oxide nanoparticles. I am facing a strange problem. Though my system is capable of producing higher coil current (we can calculate the magnetic field for a typical coil of known dimension from current), I am not being able to increase the current beyond certain value. If I place a solid metal piece inside the coil, I am able to increase the current, but for nanoparticle specimens in typical glass vials, power is just not getting transferred to the system from tank circuit. I am able to reach a maximum magnetic field of 0.8 kAmp/meter, whereas, in literature I often see magnetic field values in the order of 10-20 kAmp/meter for such nanoparticle systems of comparable weight percentage. My question is how to increase the coil current?
Am I missing something? I would like to get some help in this regard. I am open for comments and suggestions.
Advanced thank you.
Hyperthermic Isolated Lung Perfusion (HILP) can be performed using moderate or true hyperthermia (39 and 41 degrees C, respectively). Under these conditions, does it occurs a significant effusion from the sane parenchima? Is this effusion exudative or transudative in nature?
Does HILP also increases the rate of transudative effusion in the metastases-affected lung parenchima?
Thank you for your answers.
Hi, everybody. I am trying to design a hyperthermia induced drug release nano-system, containing a thermal-sensitive chemical linker which would be cleavage and release conjugated drugs after thermal treatment. It's best that this linker owns -NH2 ending.
However, i haven't found out an appropreate thermo-induced cleavaged linker between drugs and other polymers.
It seems azo linker is a candidate, which would release nirogen gas by cleavage in high temperature.
Please reccommand some text books or papers in terms of stimulus-induced cleavage of chemical bond, e.g. cleavage of disulfide linker in high inracellular glutathione (GSH) concentraion
Thank you every big man
I am starting a new work related to " magnetite nanoparticles for hyperthermia applications". Therefore I kindly request experts in this field to guide me to few important and fundamental papers on hyperthermia applications of magnetic nanoparticles, which can be useful for any beginners in this subbject.
From practical point of view (keeping aside research aspirations), what are the basic requirements of a candidate specimen for being a good system for magnetic hyperthermia applications? As per my understanding we need the followings.
1) System must be stable overa a large period of time. (I mean no settlement).
2) System must be capable of attaining hyperthermia temperature window (43-45 deg-cels).
3) System must be bio-compatible.
Any other most essential properties are required? Kindly comment.
Advanced thank you.
I am working on Iron Oxide NPs apply on Hyperthermia and Chemotherapy treatments.I read on some papers about the Hyperthermia Equipments. It is combined from the different machine such as : sensor, generator, etc.