Humulus - Science topic

Fusarium genus is a wide host phytopathogen causing significant losses in multiple crops, including hops. There is limited information on the sustainable management of Fusarium spp. in hop fields. Trichoderma is an endophytic fungus used in agriculture as a biological control agent (BCA) and as a plant growth promoter. It has been used to antagoniz...

One in every three deaths worldwide is caused by cardiovascular diseases (CVDs), estimating a total of 17.9 million deaths annually. By 2030, it is expected that more than 24 million people will die from CVDs related complications. The most common CVDs are coronary heart disease, myocardial infarction, stroke, and hypertension. A plethora of studie...

Background Hop creep continues to present an unresolved issue for the brewing industry, specifically stemming from those hops added to beer during fermentation. Hops have been found to contain four dextrin-degrading enzymes: alpha amylase, beta amylase, limit dextrinase, and an amyloglucosidase. One recent hypothesis predicts that these dextrin-deg...

Currently, there is greater production and consumption of craft beer due to its appreciated sensory characteristics. Unlike conventional beer, craft beers provide better health benefits due to their varied and high content of phenolic compounds (PCs) and also due to their alcohol content, but the latter is controversial. The purpose of this paper w...

Pain is a common undertreated worldwide complaint. The need to explore the antinociceptive potential of alternative herbal products is essential. Although used as a mild sedative, limited evidence focused on the potential antinociceptive effect of valerian and hops combination. The present study was carried out to evaluate the in vivo anti-nocicept...

Coronaviruses emerged three times in the last two decades and became a source of concern globally. Humulus lupulus plant has been used widely in medical science. Our objective in this study was to determine the effects of the crude extract of H. lupulus in inhibiting MERS-CoV and SARS-CoV-2 viruses’ replication in vitro using Vero E6 cell lines and...

The stability of alpha-acids, beta-acids and hop storage index (HSI) values under different conditions (aerobic/anaerobic, 4 • C/room temperature) was studied in a two-year trial. Six different varieties (Celeia, Aurora, Bobek, Styrian Gold, Savinjski Golding and Styrian Wolf) were used in the form of cones and pellets. Alpha-and beta-acids were de...

Bioactive compounds extracted from plant are of great value for those enterprises interested in the use of natural products; plant tissue culture techniques guarantee a reliable and constant biomass production. Hop (Humulus lupulus L.), with its wealth in bioactive compounds, may represent an invaluable resource. The present study focused on the ch...

Chikungunya virus (CHIKV) is an arthropod-borne virus that belongs to the genus Alphavirus (family Togaviridae). CHIKV causes chikungunya fever, which is mostly characterized by fever, arthralgia and, sometimes, a maculopapular rash. The bioactive constituents of hops (Humulus lupulus, Cannabaceae), mainly acylphloroglucinols, known as well as α- a...

Hops contain a wide variety of polyphenolic compounds with diverse antimicrobial properties. This study aimed to evaluate the impact of temperature on the bioactive components of samples of aqueous extracts of hops with different characteristics. A central compound rotating design model was used in order to obtain optimal conditions of temperature...

Supercritical fluid extraction from hops (Humulus lupulus L.) can be used to extract essential oil for the flavoring of beer. With a special focus on the oil composition being linked to the hop aroma, the influence of pressure and temperature on the extraction kinetics of seven oil components (β-myrcene, α-humulene, β-caryophyllene, 2-methylbutyl i...

Background The systemic inflammatory response following severe COVID-19 is associated with poor outcomes. Several anti-inflammatory medications have been studied in COVID-19 patients. Xanthohumol (Xn), a natural extract from hop cones, possesses strong anti-inflammatory and antioxidative properties. The aim of this study was to analyze the effect o...

In this work, the fresh leaves and inflorescences of Humulus lupulus L. cv. Chinook hops were investigated in order to describe their chemical composition and evaluate their biological activities. The analyses were carried out first on fresh untreated samples and then on pulverized ones using the SPME-GC-MS technique. In total, forty-two molecules...

The prevalence of ragweed (Ambrosia artemisiifolia) pollinosis has been increasing worldwide. This study focused on the behavior of autumn airborne pollen and the major ragweed allergen -Amb a 1 particle in urban Saitama, Japan, in 2016. Burkard sampler results showed that the airborne ragweed pollen scattering season was from September 1st to Octo...

Paramyrothecium foliicola is reported for the first time in Brazil and worldwide causing leaf spots on hop (Humulus lupulus). The fungus was identified with a combination of morphological and molecular information. The pathogenicity of P. foliicola to hop was demonstrated through inoculations under controlled conditions.

Hops (Humulus lupulus L.) constitute a species that grows spontaneously in the region of Calabria (South Italy), but the species’ morphological and genetic characterization have not yet been explored. Thus, we explored some morphological traits related to cones of wild hops from three Calabrian sites: Cosenza (CS), Catanzaro (CZ), and Vibo Valentia...

As aging progresses, β-amyloid (Aβ) deposition and the resulting oxidative damage are key causes of aging diseases such as senior osteoporosis (SOP). Humulus lupulus L. (hops) is an important medicinal plant widely used in the food, beverage and pharmaceutical industries due to its strong antioxidant ability. In this study, APP/PS1 mutated transgen...

The analytical quality by design (AQbD) approach is utilized for developing and validating the simple, sensitive, cost-effective reverse-phase high performance liquid chromatographic method for the estimation of xanthohumol (XH) in bulk and nanoformulations. The Box–Behnken design (BBD) is applied for method optimization. The mobile phase ratio, pH...

The benefits of medicinal plants for human health have been known since ancient times. These plants used by the public were researched and pharmaceutical products were developed with their extracts, and human beings managed to protect themselves from diseases and ailments for years by using their past knowledge. Phytotherapy is defined as "treatmen...

The antimicrobial activity of hop extracts obtained from different hop genotypes were investigated against Staphylococcus aureus and Lactobacillus acidophilus. In this study the pure xanthohumol, purified β-acids rich fraction, as well as α-acids with β-acids rich fraction were used to test antimicrobial activity against Staphylococcus aureus and L...

In the past few decades, interest in herbal medicines has been increased significantly, the reason includes, isolation, purification and identification of active principles, scientific validation of traditional uses, better compatibility of the natural molecules with human body, comparatively economical, fewer side effects, better presentation, pac...

We present a chromosome-level assembly of the Cascade hop (Humulus lupulus L. var. lupulus) genome. The hop genome is large (2.8 Gb) and complex, and early attempts at assembly were fragmented. Recent advances have made assembly of the hop genome more tractable, transforming the extent of investigation that can occur. The chromosome-level assembly...

Background: Breast cancer is the most common type of cancer in women, and vast research is being conducted throughout the world for the treatment of this malignancy by natural products using various computational approaches. Xanthohumol, a prenylated flavonoid, is known for its anticancer activity; however, the mechanism behind its action is still...

There is a great deal of interest in identifying new chemopreventive agents for colorectal cancer, one of the leading causes of cancer-related death. One promising group of candidates is the polyphenols; being natural compounds with high structural diversity, they have a very wide spectrum of anti-inflammatory, anti-oxidant and anti-cancer properti...

Hops (Humulus lupulus L.) are known worldwide as a raw material in beer production due their flavor and preservative values. The beneficial properties of the plant have been mostly associated with the female hop inflorescences (cones), which is also the part used in the brewing industry. However, some studies indicate the presence of compounds asso...

The medicinal potential of hop (Humulus lupulus L.) is widely cited in ancient literature and is also allowed in several official pharmacopoeias for the treatment of a variety of ailments, mainly related to anxiety states. This is due to the plethora of phytoconstituents (e.g., bitter acids, polyphenols, prenyl flavonoids) present in the female inf...

Total phenolic content using Folin–Ciocalteu method, antioxidant capacity by CUPRAC method and sun protection properties were measured for four different extracts of selected plants: marigold petals, carrot roots, tomato fruits and hop cones. Three types of extracts: water, oil and water-glycolic (1:4) were studied. Assessment of sun protection pro...

Varroa destructor is a parasitic mite, which is considered a severe pest for honey bees causing serious losses to beekeeping. Residual hydrolats from steam extraction of hop essential oils, generally considered as a waste product, were tested for their potential use as acaricides on V. destructor. Four hop varieties, namely Cascade, Spalt, Victoria...

Background Neuroinflammation plays an important role in cognitive decline and memory impairment in neurodegenerative disorders. Previously, we demonstrated that Humulus japonicus (HJ) has anti-inflammatory effects in rodent models of Alzheimer’s disease and Parkinson’s disease. The present study aimed to examine the protective potential of HJ extra...

Over recent years, the cultivation of hops ( Humulus lupulus L.) has spread widely in the Mediterranean, also affecting the southern regions of Spain and Italy with a typical semi-arid climate. Several and recent studies have investigated the responses of this species to the main abiotic stresses, which is an aspect of absolute relevance to the kno...

Botanicals represent a promising source of metabolites in the search for new biofungicides. In this context, this study aimed at evaluating the in vitro anti-oomycete activity of hop (Humulus lupulus L.) extracts and metabolites against Phytophthora infestans, an oomycete causing late blight disease in Solanaceae. Crude hydro-ethanolic extracts and...

INTRODUÇÃO: A psoríase é uma doença de pele que se desenvolve após sinalização inflamatória crônica e hiperproliferação de queratinócitos, além de estar associada a grande incapacidade física e psicológica decorrente da dor das lesões cutâneas, atrelada a uma má imagem corporal e extensas comorbidades. Nesse sentido, o uso de plantas medicinais eme...

Xanthohumol (XN) is the major prenylated chalcone of the female inflorescences (cone) of the hop plant ( Humulus lupulus). It is also a constituent of beer, the major dietary source of prenylated flavonoids. It has shown strong antitumorigenic activity towards various types of cancer cells. In the present study, we show the impact on human hepatoca...

Agro-food by-products are a cheap source of bioactive and functional compounds that should be used via a biorefinery approach to produce a range of bio-based products. Spent hops (SH) are an important by-product of the brewing industry and are rich in valuable ingredients such as proteins and xanthohumol (XN). Considering the increasing demand for...

«Біоекофунге-1» – це біоорганічна композиція, що виготовляється з екстрактів плодових тіл печериці садової (Agaricus bisporus (JE Lange) Imbach, 1946) та плеврота черепичастого (Pleurotus ostreatus (Jacq. Ex Fr.) P. Kumm. (1871)), а також ліофілізованих суцвіть, молодих стебел та листків хмелю звичайного (Humulus lupulus L.)[1]. Низкою досліджень в...

Humulus lupulus is a dioecious twining herb, with an outstanding vertical development capacity. Hop plants are usually grown on trellises up to 4.5 to 6.0 m high, whose management requires intense use of water, fertilizers, pesticides, and labor. In semiarid Mediterranean areas, where native resources are often scarce, the adoption of low-trellis f...

There is an increased interest in identifying beneficial compounds of plant origin that can be added to animal diets to improve animal performance and have a health-promoting effect. In the present study, nine herb species of the Norwegian wild flora or which can be cultivated in Norway were selected for phytogenic evaluation (hops, maral root, min...

The relevant social and economic costs associated with aging and neurodegenerative diseases, particularly Alzheimer’s disease (AD), entail considerable efforts to develop effective preventive and therapeutic strategies. The search for natural compounds, whose intake through diet can help prevent the main biochemical mechanisms responsible for AD on...

Background Xanthohumol (XN), a bioactive flavonoid from Humulus lupulus with anti-inflammatory properties, has potential benefits for patients with Crohn’s disease (CD), a type of inflammatory bowel disease. We recently completed and published results of a placebo-controlled phase I clinical trial demonstrating the safety and tolerability of 24 mg...

Infections with Gram-negative bacteria are still among the leading causes of infection-related deaths. Several studies suggest that the chalcone xanthohumol (XN) found in hop (Humulus lupulus) possesses anti-inflammatory effects. In a single-blinded, placebo controlled randomized cross-over design study we assessed if the oral intake of a single lo...

Objective: Female sexual dysfunction is a common distressing problem among women which may result from reducing circulating endogenous estrogen. Humulus lupulus L (Hop) has antioxidant, anti-inflammatory, anticancer, and estrogenic properties. Therefore, this study aimed to assess the efficacy of Hop on postmenopausal sexual dysfunction. Methods: S...

Isobavachalcone (IBC) is a prenylated chalcone mainly distributed in some Fabaceae and Moraceae species. IBC exhibits a wide range of pharmacological properties, including anti-bacterial, anti-viral, anti-inflammatory, and anti-cancer activities. In this study, we attempted to construct the heterologous biosynthesis pathway of IBC in tobacco ( Nico...

: Hop essential oil, in addition to alpha-acids, is one of the most valuable parameters for brewers, since it is responsible for beer aroma. The hop oil content and hop oil chemical composition deliver various aromas to beer. During storage, the hop chemical composition undergoes many physical and chemical changes that impact its quality. The main...

Omics approaches in plant analysis find many different applications, from classification to new bioactive compounds discovery. Metabolomics seems to be one of the most informative ways of describing plants’ phenotypes, since commonly used methods such as liquid chromatography–mass spectrometry (LC-MS) and nuclear magnetic resonance spectroscopy (NM...

Cannabaceae are a relatively small family of angiosperms, but they include several species of huge economic and cultural significance: marijuana or hemp (Cannabis sativa) and hops (Humulus lupulus). Previous phylogenetic studies clarified most deep relationships in Cannabaceae, but relationships remain ambiguous among several major lineages. Here,...

Hop (Humulus lupulus L.) is a plant used as an ingredient in beer or employed for its anti-inflammatory properties. The cultivation of hops is currently dedicated to the brewing industry, where mainly female flowers are used, whereas aerial parts, such as leaves, are considered coproducts. Osteoarthritis is the most common musculoskeletal disease a...

Humulus lupulus or Hop shoots is a hardy dioecious perennial climbing plant that belong to the family Cannabinaceae. It is well-known in the brewing business for its high value. The Strobiles or 'cones' of the female plant are used for commercial purposes, whilst the male plants are used only for hybridization. Hop shoots is a delicate vegetable in...

Silver nanoparticles (AgNPs) are well known to have antimicrobial activity, but very little is known about the effect of AgNPs on various enzyme activities. They (AgNPs) are valuable metal nanoparticles that exhibit exceptional properties compared to their bulk materials. Humulus lupulus L. (hops) is an important medicinal aromatic plant used in in...

Abiotic and biotic stresses can lead to changes in host DNA methylation, which in plants is also mediated by an RNA-directed DNA methylation mechanism. Infections with viroids have been shown to affect DNA methylation dynamics in different plant hosts. The aim of our research was to determine the content of 5-methylcytosine (5-mC) in genomic DNA at...

The stability of the agricultural and technological properties of hop varieties over the course of time and under changing climate is essential for both growers and brewers. This study is a typical case of monitoring 12 hop varieties selected from a collection of hop genetic resources, that were evaluated in the years 2009 to 2021. The assessed par...

This work aims to summarize the cultivation experiences carried out in Sicily in two experimental sites. Low- height trellis systems were adopted, mulching treatments were tested and finally, a sensory analysis was carried out, allowing to get some preliminary information on crop management, useful for a wider spread of hop among local farms.

Background: The use of herbal extracts could represent an advantageous approach for treating sleeping disorders, especially in mild-to-moderate conditions, before the onset of a specific therapy with first-line drugs. Specifically, the focus was posed about the use of extracts from Valeriana officinalis, Ziziphus jujuba, and Humulus lupulus. Multip...

Isobavachalcone (IBC) is a prenylated chalcone mainly distributed in some Fabaceae and Moraceae species. IBC exhibits a wide range of pharmacological properties, including anti-bacterial, anti-viral, anti-inflammatory, and anti-cancer activities. In this study, we attempted to construct the heterologous biosynthesis pathway of IBC in tobacco ( Nico...

In this study, essential oils (EOs) and hydrolates (Hys) from Italian hemp (Cannabis sativa L. Kompolti cv.) and hop (Humulus Lupulus L., Chinook cv.) supply chains were chemically characterized and tested to investigate their apoptotic potential for the first time. Headspace–Gas Chromatography–Mass Spectrometry (HS-GC-MS) techniques were performed...

Hop (Humulus lupulus L.) is grown mainly for the production of beer. The flowers of the female plant give it the bitter taste and pungent aroma. There are a large number of hop varieties differing in their α-acid content, essential oil levels and odor profiles. Aside from their use in brewing, more recently, hops have been used for the pharmacologi...

Tree of Heaven (Ailanthus altissima), a tree species native to China, was introduced into Europe as an ornamental plant about 250 years ago. It is known for its invasive spread with negative impacts on natural ecosystems as well as human infrastructure. Its control is inevitable in some areas, e.g. transportation corridors, for safety reasons. Furt...

Bioactive compounds extracted from plant essences are of great value for those enterprises interested in natural products; plant tissue culture techniques guarantee a reliable and constant biomass production. Hop ( Humulus lupulus L.), with its wealth in bioactive compounds, is an unvaluable resource. The present study focused on the characterizati...

Background: This study’s aim was to evaluate the efficacy and safety of 14-days oral supplementation of a standardized hops extract containing 30% alpha acids, Humulus lupulus L. on individuals with osteoarthritis of the knee. Methods: Thirty-three subjects (26 female, 7 male, 57.0 ± 6.9 years) participated in this randomized, double-blind, multi-...

The female flowers of the Humulus lupulus plant or Hops have been used extensively within the brewing industry for their aroma and bitterness properties. It was also found that beer that contained hops was less likely to spoil, thus revealing the antimicrobial potential of these plants. One species of bacteria, Mycobacterium spp., is of particular...

Humulus lupulus L. is a dioecious herbaceous perennial plant with a climbing habit, whose female inflorescences, commonly known as cones, produce and accumulate bitter substances and essential oils. The present study aimed to assess the adaptability of some American hop varieties (Cascade, Chinook, and Comet) in the Mediterranean environment of the...

Purpose The aim of the study was to determine if xanthohumol, a prenylated chalcone found in Hop (Humulus lupulus), has anti-inflammatory effects in healthy humans if applied in low doses achievable through dietary intake. Methods In a placebo-controlled single-blinded cross-over design study, 14 healthy young men and women either consumed a bever...

The slow pace of discovery of bioactive natural products can be attributed to the difficulty in rapidly identifying them in complex mixtures such as plant extracts. To overcome these hurdles, we explored the utility of two machine learning techniques, i.e., Elastic Net and Random Forests, for identifying the individual anti-inflammatory principle(s...