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Human Neuroanatomy - Science topic

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I observed such an anomaly on a dried skull, and wonder if related to any neuro-anatomical subsequent/associated anomaly. Thanks+
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Allargamento impronta vasi meningei (maggiore spessore e profondità) rispetto al normale. Maggiore profondità e grandezza delle foveole o granulazioni del Pacchioni .oltre l'interno del cranio guarda anche se alterazioni arrivano tavolato esterno; tutti questi caratteri possono indicare presenza di tumore meningi (meningioma). Bibl: potresti vedere M. Rubini 2008 elementi di paleopatologia; Ortener and Putschar identification of pathological  conditions in human skeletal remains; per altra bibl. guarda Minozzi and Canci Archeologia dei resti umani. 
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By way of comparison, there are an estimated 22000 - 51000 noradrenergic neurons in the human brain - all in the locus coeruleus. How many serotonergic neurons are there in the human brain?  How many subvarients? And where can they be found? And in comparison, how many serotonergic neurons are present elsewhere in the body (eg., in the human gut)?
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Dear Prof. Schwartz:
I attended, your lectures at the INPP Conference in Frutillar (I presented a poster on Contemporary Psychopathology Seminar for Residents)
Regarding your question, I found this in an article by Horning JP. Journal of Chemical Neuroanatomy 26 (2003) 331–343
The development of histological and imaging techniques has demonstrated the great homologies between the organizations of the serotonergic system in many mammalian species including human. With a total number of about half a million in the human raphe nuclei, serotonin neurons have a dense and divergent projection extending to all divisions of the brain, but still with a specific areal and cellular targeting in different circuits of the sensory, motor or limbic systems.
Might you need further help, please do not hesitate to write (l.varela@uandresbello.edu)
Best regards,
Luis Varela
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How is cortical surface area related to cortical folding (e.g. measured by FreeSurfer) and what is the additional value in measuring both variables?
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My impression is that surface area is literally that, if the cortical mantle was spread out into a sheet what would the surface area at. The folding instead is the pattern of folks that make of the gyri. Neither are measures that most labs look at when using Freesurfer (thickness and volume are most common). I would take a look at this paper to get a sense of what Freesurfer means by cortical folding.