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Human Development Theory - Science topic

Continuous sequential changes which occur in the physiological and psychological functions during the life-time of an individual.
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Publications related to Human Development Theory (6,125)
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During neuronal differentiation, neuroprogenitor cells become polarized, change shape, extend axons, and form complex dendritic trees. While growing, axons are guided by molecular cues to their final destination, where they establish synaptic connections with other neuronal cells. Several layers of regulation are integrated to control neuronal deve...
Article
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Introduction Ulcerative colitis (UC) is an inflammatory bowel disease characterized by repeated remissions and relapses. Immunosuppressive drugs have facilitated the induction and maintenance of remission in many patients with UC. However, immunosuppressive drugs cannot directly repair impaired intestinal mucosa and are insufficient for preventing...
Article
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Research question and the most important issue in this paper relates to the determination of CO2 emission drivers in EU and the possibility of its reduction in the era of the fourth industrial revolution. EU strategies and economic policies are directed toward sustainable development, with special emphasis on reducing CO2 emissions towards carbon n...
Article
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The use of cell-culture models to investigate development and disease of the cerebellum is a recent advance, facilitated by the discovery that patterning of precursors is capable of giving rise to cells with specific neuronal identity. Pluripotent stem cell–derived organoids, which exhibit self-organisational characteristics reminiscent of early ce...
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The aim of this study is to examine past literature from a reductionist approach of findings derived from academically gifted and talented youth research, and to examine the factors explaining the roots of such abilities. Also explored are common human development theories of social information processing perspective, social cognitive, attachment a...
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Humans have a flexible and accurate ability to coordinate their movement in time with external rhythms. However, it remains unclear when and how, during their development, human children acquire the ability to adjust tempo and control the timing of their movement toward others. A previous study suggested that such self-regulation of coordination de...
Preprint
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During cortical development, human basal radial glial cells (bRGCs) are highly capable of sustained self-renewal and neurogenesis. Selective pressures on this cell type may have contributed to the evolution of the human neocortex, leading to an increase in cortical size. bRGCs have enriched expression for Forkhead Box P1 (FOXP1), a transcription fa...
Article
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The precise regulation of gene expression is fundamental to neurodevelopment, plasticity and cognitive function. Although several studies have profiled transcription in the developing human brain, there is a gap in understanding of accompanying translational regulation. In this study, we performed ribosome profiling on 73 human prenatal and adult c...
Preprint
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Genetic inner ear disorders are among the most common congenital abnormalities and lead to hearing loss and balance disorders. Ideally, tissue culture models of the inner ear should contain a functional unit combining otic sensory and nonsensory cell types to recapitulate the varied etiologies of inner ear disorders. Here, we evaluated cell type di...
Preprint
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Neurovascular coupling that links neural activity to localized increases in blood flow is essential both for brain function and to prevent tissue injury. In the healthy human brain, this underlies an association between the duration of EEG microstates, which represent coordinated and metastable activation of neuronal ensembles, and increases in hem...
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Science and Technology has become an inseparable part of the well-being of all humans and other life form that exist. Development of science and technology is only due to the scientific temperament and affective connection of human minds towards science. Science is a discipline that provide the base for critical, logical and rational thinking which...
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Although first noted discussions at the United Nations (UN) level about corruption are reaching their 50th anniversary, the core of the UN activity against corruption has taken place in the last quarter of a century. The 2021 special debate at the UN General Assembly was an opportunity for the institution to pause and reflect about its role over th...
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Designing studies of immunotherapy is limited due to a lack of pre-clinical models that reliably predict effective immunotherapy responses. To address this gap, we developed humanized mouse models of colorectal cancer (CRC) incorporating patient-derived xenografts (PDX) with human peripheral blood mononuclear cells (PBMC). Humanized mice with CRC P...
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Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into biologically distinct subgroups, suggesting that a personalized approach to therapy would be beneficial¹. Mouse modelling and cross-species genomics have provided increasing evidence of discrete, subgroup-specific developmental origins². However, the anatomical an...
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The fetal placenta is a source of hormones and immune factors that play a vital role in maintaining pregnancy and facilitating fetal growth. Cells in this extraembryonic compartment match the chromosomal sex of the embryo itself. Sex differences have been observed in common gestational pathologies, highlighting the importance of maternal immune tol...
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The cerebral cortex forms early in development according to a series of heritable neurodevelopmental instructions. Despite deep evolutionary conservation of the cerebral cortex and its foundational six-layered architecture, significant variations in cortical size and folding can be found across mammals, including a disproportionate expansion of the...
Research
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The goal of this study was to explore the connection between authentic leadership, spirituality, and human development theory to determine if spirituality contributes to the emergence or formation of an authentic leadership identity. An interdisciplinary research approach was conducted by reviewing literature on authentic leadership, spirituality,...
Preprint
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The human spinal cord contains diverse cell types, governed by a series of spatiotemporal events for tissue assembly and functions. However, the spatiotemporal regulation of cell fate specification in the human developing spinal cord remains largely unknown. Single-cell RNA sequencing and spatial transcriptomics techniques have advanced the underst...
Preprint
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Humans can attribute mental states to others, a capacity known as Theory of Mind. However, it is unknown to what extent this ability results from an innate biological endowment or from experience accrued through child development, particularly exposure to language describing others' mental states. We test the viability of the language exposure hypo...
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The concept of Human Capital (HC) recently received attention from scholars. They hypothesize that HC represents human factor with combined intelligence, expertise and skills of individuals. Human Capital Management is considered as an integrated approach to manage and develop human capabilities thus achieve high performance. Human Capital Manageme...
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Telencephalic organoids generated from human pluripotent stem cells (hPSCs) are a promising system for studying the distinct features of the developing human brain and the underlying causes of many neurological disorders. While organoid technology is steadily advancing, many challenges remain, including potential batch-to-batch and cell-line-to-cel...
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A recently developed human PSC-derived skin organoid model has opened up new avenues for studying skin development, diseases, and regeneration. The current model has limitations since the generated organoids are enclosed, circular aggregates with an inside-out morphology with unintended off-target development of cartilage. Here, we first demonstrat...
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Glioblastoma (GBM) remains the most frequently diagnosed primary malignant brain cancer in adults. Despite recent progress in understanding the biology of GBM, the clinical outcome for patients remains poor, with a median survival of approximately one year after diagnosis. One factor contributing to failure in clinical trials is the fact that tradi...
Chapter
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The development of personal computing, with a particular focus on the history of Apple, is analysed. It is demonstrated that under a capitalist system of production and consumption a fundamental contradiction exists between the idealised promise that technology will contribute to the development human freedom conceived in individualized terms throu...
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Bioengineered human skeletal muscle tissues have emerged in the last years as new in vitro systems for disease modeling. These bioartificial muscles are classically fabricated by encapsulating human myogenic precursor cells in a hydrogel scaffold that resembles the extracellular matrix. However, most of these hydrogels are derived from xenogenic so...
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Intersex people are viewed from the medicalised lens of having a “disorder” of sex development rather than a difference in sex development. This inherent indifference to diversity is also visible in LGBTQIA+ advocacy, as they were initially excluded from the Yogyakarta Principles promoting the human rights of sexual and gender minorities. This pape...
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Bilirubin-induced neurological damage (BIND) has been a subject of studies for decades, yet the molecular mechanisms at the core of this damage remain largely unknown. Throughout the years, many in vivo chronic bilirubin encephalopathy models, such as the Gunn rat and transgenic mice, have further elucidated the molecular basis of bilirubin neuroto...
Preprint
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Escherichia coli has been used as an indicator of fecal pollution in environmental waters. However, its presence in environmental waters does not provide information on the source of water pollution. Identifying the source of water pollution is paramount to be able to effectively prevent contamination. The present study aimed to identify E. coli mi...
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Recent advances in regenerative therapy have placed the treatment of previously incurable eye diseases within arms’ reach. Achromatopsia is a severe monogenic heritable retinal disease that disrupts cone function from birth, leaving patients with complete colour blindness, low acuity, photosensitivity and nystagmus. While successful gene-replacemen...
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Whether the Hu line will move into west China is a serious issue that has implications for socioeconomic development, human geography and the environment. Based on the data related to four different levels of radiative forcing detailed in CMIP6, in this study, we analyzed the trends in precipitation and NPP (net primary productivity) on both sides...
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This study sets out to theorize and conceptualize internal stakeholders’ provision of Educational Leadership for the Members of the Association of African Universities (AAU). It reviews research materials, policies and modalities in developing educational leadership, African Philosophies of Education (APE) and interviews of university academic staf...
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Hospitality is very important in Tamil culture. Such qualities are admirable in life ethics. And the virtues of Tamil life are amazing, special, and the best guide for our lives. And through literature, we can know the excellence of Tamil culture. It is to preserve the virtues of hospitality and develop humanity through friendship. It is the opinio...
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Sericulture is an agro-based industry that mainly focuses at rearing of silkworms with the main objective of silk production. In addition to the silk, a chain of secondary products have also been produced, having excellent economic value. Sericulture by-products have remarkable application as in preparation of compost, in human medicine, handicraft...
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Is it possible to conduct a revolution in criminal procedure law in Indonesia, the answer is possible, but whether or not to come back again becomes a debate in the discussion of the Criminal Procedure Code Bill. Displacement of legal traditions is not prohibited. Humans and the complexity of their legal culture continue to grow, so the law is ther...
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Study in hand is planned to dig out the important segment of society i.e. Demographic Dividend that is an accelerating force for socioeconomic development. Demographic Dividend is a situation in which working age population increased and dependency ratio is decreased. This working force is a human capital for any state, its meticulous utilization t...
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Dentistry is changing rapidly in a dynamic and challenging mode and is incorporating digital technology, communication, and managerial skills for profitable enterprises. On the new dental horizon, the profession requires engaging and inspiring role models and leaders. Ιdentifying and developing human soft skills can improve quality issues and guara...
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Human intestinal organoids (HIOs) generated from human pluripotent stem cells hold great promise for modeling human development and as a possible source of tissue for transplantation. HIOs generate all of the main epithelial and mesenchymal cell types found in the developing human intestine and mature into intestinal tissue with crypts and villi fo...
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This study investigates the determiners of informal economy at the European Territory. The impact of financial development, human capital, unemployment, inflation, and economic freedom is discussed with various fixed effect models. While the influence of unemployment on informal economy increases above a certain welfare, the influence of unemployme...
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Investing in higher education is notable as a means of developing human capital. As a newly converted university, providing great services and offering programs relevant to societal needs is expected. It is deemed necessary to conduct a status assessment of the current condition of the university to determine where it can improve instruction and ph...
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This paper assesses the effect of foreign direct investment (FDI) on the industrialization of African economies. In particular, we address the nonlinearity issue and investigate the role of the recipient countries’ absorptive capacities as a catalyst of foreign investments' spillover effects. The empirical framework considers a panel of 46 countrie...
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Cardiomyopathy is currently the leading cause of death for patients with Duchenne muscular dystrophy (DMD), a severe neuromuscular disorder affecting young boys. Animal models have provided insight into the mechanisms by which dystrophin protein deficiency causes cardiomyopathy, but there remains a need to develop human models of DMD to validate pa...
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Leukemia cells re-program their microenvironment to augment blast proliferation and enhance treatment resistance. Means of clinically targeting such niche-driven treatment resistance remain ambiguous. We develop human induced pluripotent stem cell (hiPSC)-engineered niches to reveal druggable cancer-niche dependencies. We reveal that mesenchymal (i...
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China Pakistan Economic Corridor (CPEC) is considered a massive investment that can change the economic scenario of Pakistan. The purpose of the study is to examine the contribution to the economic growth of the sectors where CPEC is investing. This research uses time-series data for 31 years to investigate the impact of macro-economic variables li...
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This study examined the relationship between intellectual capital development and competitive advantage. the objectives of the study were to examine how the various dimensions of intellectual capital development relates with the measures of competitive advantage. The various concepts on which the study was founded were extensively reviewed. Based o...
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There is little information about the functional expression of the multidrug resistance (MDR) transporters P-glycoprotein (P-gp, encoded by ABCB1) and breast cancer resistance protein (BCRP/ABCG2) in the developing blood-brain barrier (BBB). We isolated and cultured primary human fetal brain endothelial cells (hfBECs) from early and mid-gestation b...
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Paying attention to the mechanisms of the GTFP of the marine economy and designing a scientific and reasonable optimization path are the keys to achieving a “win-win” balance between environmental protection and high-quality marine development. Therefore, this paper considers the rigid constraints of resources and negative environmental effects to...
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A hematopoietic stem cell (HSC) gene therapy (GT) using lentiviral vectors has attracted interest as a promising treatment approach for neuropathic lysosomal storage diseases. To proceed with the clinical development of HSC-GT, evaluation of the therapeutic potential of gene-transduced human CD34+ (hCD34+) cells in vivo is one of the key issues bef...
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Congenital heart defects (CHD) are the most common congenital anomalies in liveborn children. In contrast to syndromic CHD (SCHD), the genetic basis of isolated CHD (ICHD) is complex, and the underlying pathogenic mechanisms appear intricate and are incompletely understood. Next to rare Mendelian conditions, somatic mosaicism or a complex multifact...
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Autism spectrum disorders (ASDs) are a set of disorders characterised by social and communication deficits caused by numerous genetic lesions affecting brain development. Progress in ASD research has been hampered by the lack of appropriate models, as both 2D cell culture as well as animal models cannot fully recapitulate the developing human brain...
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Human cytomegalovirus (HCMV) is the leading viral cause of congenital disease and permanent birth defects worldwide. Although the development of an effective vaccine is a public health priority, no vaccines are approved. Among the major antigenic targets are glycoproteins in the virion envelope, including gB, which facilitates cellular entry, and t...
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The adolescent brain undergoes tremendous structural and functional changes throughout puberty. Previous research has demonstrated that pubertal hormones can modulate sexually dimorphic changes in cortical development, as well as age‐related maturation of the neural activity underlying cognitive processes. However, the precise impact of pubertal ho...
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Yeasts are often considered microorganisms for producing human therapeutic glycosylated end-products at an industrial scale. However, the products with non-humanized glycans limited their usage. Therefore, various methods to develop humanized glycosylated end-products have been widely reported in yeasts. To make full use of these methods, it is nec...
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Effective organizations strive to focus on the behavioral patterns of their employees. They are designed to develop human behaviors that are best suited for the effectiveness of an organization. Organizational justice is one of the main key factor that invest in developing a positive behavior of the employees towards their organization as well as t...
Preprint
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Autism spectrum disorder (ASD) is a heterogenous, early-onset neurodevelopmental disorder with multifactorial aetiology. There are hundreds of genes that contribute to ASD. Additionally, several environmental factors, such as neurotoxic compounds, endocrine modulators, and neuropsychiatric medications, have been associated with ASD outcomes. We inv...
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The spine has essential roles in supporting body weight, and passaging the neural elements between the body and the brain. In this study, we used integrated single-cell RNA sequencing and single-cell transposase-accessible chromatin sequencing analyses to reveal the cellular heterogeneity, lineage, and transcriptional regulatory network of the deve...
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High-grade serous ovarian cancer (HGSOC) has poor prognosis and new treatment modalities are needed. Immunotherapy, with checkpoint inhibitors, have demonstrated limited impact. To evaluate the suitability for immunotherapeutics, contextualized preclinical models are required to secure meaningful clinical translation. Therefore, we developed and ch...
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Building on and going beyond Young and Muller’s theory of powerful knowledge, this article seeks to articulate a model of a future-oriented, knowledge-rich curriculum by invoking David Lambert’s capabilities approach and Bildung-centred Didaktik. The curriculum is knowledge rich in three respects. First, it is informed by a vision of education cent...
Research Proposal
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It is well known that economics and social sciences have imported from Physics and mostly from Mathematics developed for other exact and biological sciences many of the procedures, theories, and even ways of thinking that are not necessarily adequately inserted in the social and economic evolution at a global level. They have been necessary steps i...
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This paper looks at the less-explored relationship between the law of the sea and human rights with a focus on investigating the potential role of UNCLOS III in developing human rights discourse and vice versa (i.e. rights-based take on UNCLOS III). The law of the sea is one of the vibrant branches of international law. Unlike other disciplines, ho...
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The analysis of postmortem protein degradation has become of large interest for the estimation of the postmortem interval (PMI). Although several techniques have been published in recent years, protein degradation-based techniques still largely did not exceed basic research stages. Reasons include impractical and complex sampling procedures, as wel...
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With the continuous development of social economy, industry has become the main industry that contributes to the economy. In the process of industrial development, human operation is gradually replaced by machine operation, and the replacement of machines is followed. Over the years, machines have become more and more important in industry. However...