Histamine - Science topic

Objective: we conducted a literature survey on nutritional strategies for the management of histamine intolerance to produce an integrative literature review in databases. Methodology: After removing all duplicates, relevant articles were selected in three distinct phases. These phases consist of a gradual process of article selection and verificat...

Mast cells play a key role in innate immunity by mediating host defense and maintaining tissue balance. They achieve this through the controlled release of bioactive mediators such as histamine, heparin, leukotrienes, and prostaglandin D2. Their functional diversity is enabled by multiple receptor systems that coordinate differentiation, maturation...

The gastroprotective effects of the fractions of ethanol extract of Moringa oleifera leaves (MOEE) were examined. Gastric antisecretory effect and antimicrobial activity against Helicobacter pylori were used as indices of gastroprotection. MOEE was fractionated to yield five major fractions (K1–K5). Preliminary quantitative phytochemical analysis w...

Background Chronic kidney disease-associated pruritus (CKD-aP) is an itch directly associated with kidney disease. Currently, there is no bibliometric analysis literature in this field. Therefore, this study employs bibliometric methods to understand the characteristics, hotspots, and frontiers of global CKD-aP research in the past 20 years. Metho...

In allergic inflammation (type I hypersensitivity), the antigen-antibody reaction triggers mast cell degranulation. Inflammatory mediators released by activated mast cells induce vascular hyperpermeability, leading to pronounced inflammation. Understanding these mechanisms is essential for developing novel therapeutic strategies. Vascular permeabil...

Accurate, real‐time detection of neurotransmitters is crucial for elucidating the mechanisms of brain function and tracking the progression of neurological diseases. Biosensors usually face poor reusability induced by difficulties in probe‐target separation, hindering their application for continuous monitoring. In this work, a semiconducting carbo...

Introducción: La urticaria acuagénica (UA) en menores de edad es una patología dermatológica poco común que se caracteriza por la aparición de pápulas pruriginosas tras el contacto con el agua. Desde su identificación en 1964, esta condición sigue siendo enigmática, posiblemente debido a factores genéticos e inmunológicos, aunque el mecanismo exact...

Objectives Histamine, mainly produced in mast cells (MC), plays a key role in allergy and inflammation. Measuring its urinary metabolites, N-methylhistamine (NMH) and 1-methyl-4-imidazoleacetic acid (MIMA), is essential in assessing histamine-related pathologies. Patients with concurrent systemic mastocytosis (SM) and hereditary alpha tryptasemia (...

Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns. Quinolines hold potential therapeutic applications for the treatment of respirat...

The soil microbiome drives plant health and productivity. Recently, Sun and colleagues described a unique plant–microbe signaling cascade that enables selenium nanoparticle (SeNPs) formation by rhizosphere microbiota. These SeNPs boost maize performance by enriching plant-beneficial bacteria in a dose-dependent manner, offering novel paradigm for n...

Background/Objectives: Elimination diets targeting amines and salicylates have been used since the 1980s to diagnose pharmacological food intolerance in individuals with atopic dermatitis (eczema), yet supporting evidence regarding relevance is limited. To our knowledge, this systematic review with meta-analysis is the first to examine the prevalen...

Background Major depressive disorder (MDD) is associated with mitochondrial dysfunction and programmed cell death (PCD), though the underlying mechanisms remain unclear. This study aimed to investigate the molecular pathways involved in MDD using a transcriptomic analysis approach. Methods Transcriptomic data related to MDD were obtained from publ...

Çörek otu veya N. sativa L., dünya çapında geniş bir alana yayılmış olan değerli bitkiler arasında popüler bir şifalı ottur. Geleneksel tıpta, solunum, sindirim ve kardiyovasküler sistemlerle ilgili hastalıkları tedavi etmek için kullanılmıştır. Timokinon, özellikle Nigella sativa L. bitkisinde bulunan bitki kökenli bir bileşik olan timolün türevid...

This study evaluated the effects of adding the autochthonous cultures Limosilactobacillus mucosae CNPC007 (LM) and Lactiplantibacillus plantarum CNPC003 (LP), originally isolated from goat milk and goat cheese, respectively, on microbiological safety, microbiota composition (analyzed through 16S rRNA gene metataxonomic sequencing), and biogenic ami...

Purpose Infusion-related reaction (IRR) is a common adverse event induced by rituximab. Although first-generation histamine 1 receptor antagonists (H1RAs) are commonly used to prevent IRR, evidence on IRR suppression by the second-generation H1RA bepotastine is scarce. In this study, we assessed the inhibitory effects of bepotastine on rituximab-in...

Grape pomace is the largest by-product in the oenological industry, and in recent years, there have been multiple attempts to turn it into a high-value product, such as a fining agent. However, most of these attempts have usually been conducted with low volumes of wine, and/or in static conditions, using a long contact time between the fibre and wi...

With the development of medicine and society, more and more people have been diagnosed with chronic urticaria, which has gradually attracted people 's attention, and dietary intervention has become a method for many people to treat chronic urticaria. The current research has achieved remarkable results in the treatment of hives with specific dietar...

Background Immune checkpoint inhibitors (ICI) and chemotherapy, including antibody-drug conjugates, are widely used for the treatment of patients with advanced unresectable or metastatic urothelial carcinoma (UC). The majority of elderly patients receive concomitant medications to address various comorbidities. We aimed to evaluate the impact of co...

Introduction Standard premedication for paclitaxel-based chemotherapy includes dexamethasone and an histamine 1-antagonist to prevent hypersensitivity reactions (HSRs). However, the pharmacological rationale for dexamethasone is limited, and its use is associated with adverse effects such as hyperglycaemia, insomnia and immunodeficiency, negatively...

Based on dual-template molecular imprinting polymerization technology, a fluorescent molecularly imprinted polymer doped with CdSe/ZnS quantum dots was developed to construct a “Turn-on” fluorescence sensor for the rapid, sensitive, and specific detection of two biogenic amines. The biogenic amines bind to the quantum dots, which eliminates surface...

Itch is a commonly experienced symptom of skin diseases such as eczema. Topical corticosteroid medications are widely used in chronic itch conditions but can lead to skin thinning, and in certain cases, topical corticosteroid withdrawal. As such, non-pharmaceutical alternatives are being researched. The present research explored affective touch (sl...

The concentration of biogenic amines in wheat straw silage ensiled with urea (UWS), poultry litter (PLWS), watermelon peels (WPWS) and pineapple peels (PPWS) for 0, 6, 12, 18, 24, and 30 fermentation days was determined In Federal University Dutse, Jigawa state. The experiment was conducted using a factorial randomized complete block design. Wheat...

Peptic ulcer disease (PUD) is a significant gastrointestinal disorder that affects millions of people worldwide, imposing substantial burden on individuals, healthcare systems and economies. The available treatment options are not devoid of attendant sequalae. The search for less toxic, more effective and cheaper alternatives has continued to be ar...

Background: Urolithins, intestinal metabolites of ellagic acid, have various physiological properties including anti-inflammatory effects. In addition, the anti-allergic effect of urolithin ingestion in a mouse model of pollinosis has been reported. However, the effect of urolithins on mast cell degranulation has not been reported. To investigate t...

Research on kappa-opioid receptor (KOR) regulation of pain and itching has focused primarily on spinal and peripheral levels. However, the role of central KOR in this process, as well as the mechanisms exacerbating negative emotional responses to pain and itching, remains unknown. Therefore, this study aimed to utilize the advantages of intracerebr...

Blood transfusion is one of the causes of anaphylaxis during general anaesthesia. In most cases, adrenaline administration quickly alleviates circulatory failure and its continuous administration for days is very rare. We present the case of a 79‐year‐old man who experienced prolonged anaphylactic circulatory failure with increased histamine and tr...

Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder characterized by abdominal pain, altered bowel habits, and discomfort. This narrative review explores the current understanding of IBS pathophysiology, diagnosis, and treatment, with a focus on the role of histamine in gastrointestinal disorders. The review summarizes t...

In this study, the real-time shelf life of frozen fillets of two different types of fish, tuna (Thunnus albacares) and hake (Merluccius hubbsi), was studied, simulating a bulk system sale. A glaze treatment was used on all the samples at the beginning, and during the 60-day storage period, the glaze was reapplied at regular intervals on half of the...

Antecedentes: Las aminas pueden clasificarse en varias categorías, como aminas biogénicas (dopamina, serotonina, norepinefrina, histamina) y aminas vasoactivas sintéticas (adrenalina, noradrenalina, dobutamina). Las aminas neurotransmisoras, como la dopamina y la serotonina, son dianas terapéuticas clave en el tratamiento de enfermedades neuropsiqu...

Introduction: Infection of Helicobacter pylori (H. pylori) is a prevalent factor for acid peptic disease in the world especially in developing countries. This study assesses its prevalence and possible correlates among patients attending the Shahida Islam Teaching Hospital, Lodhran. Objectives: To find out the prevalence of H. pylori and how it rel...

In this study, we demonstrate that red light is the most critical light component for promoting healthy maize growth during Fusarium verticillioides infection. Red light receptors PHYTOCHROME B (PHYB) and C (PHYC) play essential roles in maize defense against this pathogen. Overexpression of PHYC in maize enhances resistance to F. verticillioides....

Kounis syndrome is a type of acute coronary syndrome that occurs when a chemical mediator produced by mast cell activation leads to coronary artery vasospasm. This can happen due to anaphylaxis, anaphylactoid reactions, allergies, or hypersensitivities. There are three variants of Kounis syndrome, including vasospastic allergic angina, an atheromat...

Allergic asthma is an inflammatory condition characterized by the release of pro-inflammatory cytokines and the expansion of mucus-producing cells. This research aimed to evaluate the impact of Kaempferol 3-O-gentiobioside (K3G), extracted from Sauropus spatulifolius Beille leaves, on inflammatory cytokine secretion and mucus overproduction in IL-1...

A custom-designed microneedle sampling system was prepared using dynamic mask microstereolithography; this sampling system was used for determination of histamine content in fresh, histamine-spiked, and spoiled tuna flesh. Lateral flow (test strip) assays were successfully utilized in the microneedle sampling system to assess histamine content. Goo...

Histamine is catalyzed by histidine decarboxylase (HDC), which plays important roles in many physiological and pathological processes, but its role in angiogenesis has not been thoroughly clarified. Here we report that HDC is highly expressed in Ly6C⁺ macrophages, rather than in endothelial cells using Hdc-GFP transgenic mice with hindlimb ischemia...

In-depth knowledge of the microbes responsible for biogenic amine (BA) production during soy sauce fermentation remains limited. Herein, the variations in the BA profiles, microbial communities, and microbes involved in BA production during the fermentation of soy sauce through Japanese-type (JP) and Cantonese-type (CP) processes were compared. BA...

The preservation of fermented stinky sea bass (FSSB) has always been a major challenge. In this study, four preservation methods, including partial freezing (PF), freezing (F), irradiation + partial freezing (IPF), and irradiation + freezing (IF), were employed, and their effects on the storage quality of vacuum-packed fermented stinky sea bass wer...

Ikan asap merupakan salah satu produk olahan perikanan yang digemari karena rasanya khas dan aromanya yang sedap spesifik. Proses pengasapan menggunakan teknik konvensional memiliki umur simpan yang lebih pendek. Penjualan ikan asap tanpa pengemasan memungkinkan terpaparnya mikrob dan kapang kontaminan yang dapat memengaruhi mutunya. Pengemasan den...

Histamine intolerance is a common disorder associated with an impaired histamine metabolism. It should be considered in individuals with sporadic or repeated anaphylaxis-like symptoms after seafood consumption. We encountered a 26-year-old male patient who experienced recurrent episodes of anaphylaxis-like symptoms after ingesting seafood. A detail...

Pindang is a popular traditional fish product in Indonesia that has been produced for decades. Scombroid fish such as tuna, mackerel, and scad, which have a naturally high level of histidine, are commonly used to make pindang . Hence, improper handling and processing can lead to the accumulation of histamine, potentially causing health issues. Due...

The aim of this study was to investigate the effect of high hydrostatic pressure (HHP) treatment on the free amino acid (FAA) and biogenic amine (BA) content in dry sausages made from chicken, mangalica, pork, horse, and deer meat during storage. Sausages were treated with HHP at 600 MPa for 5 min and stored for 5 weeks at 8 °C. FAA and BAs were an...

Angiopoietin2 (Ang2), a regulator of angiogenesis, is stored with other pro-inflammatory and pro-thrombotic mediators, in endothelial-specific vesicles called Weibel-Palade bodies (WPBs). The WPB secretagogue, histamine, delays Ang2 secretion by activating Rab46-specific trafficking of Ang2-positive WPBs to the microtubule organising centre (MTOC),...

A study by An et al. sheds a novel light on the potential role of histamine 2 receptor (H2R) deficiency in attention-deficit/hyperactivity disorder (ADHD), which could be a future therapeutic target of ADHD. This spotlight provides an overview of the current knowledge of the histaminergic system and proposes future directions.

A highly sensitive ultra-performance liquid chromatography coupled with triple quadruple mass spectrometry (UPLC-TQ-MS) was applied for simultaneous determination of seven biogenic amines (cadaverine, putrescine, histamine, spermine, tyramine, phenyethylamine, and tryptamine) in Montenegrin red Vranac and Kratošija (Vitis vinifera L.) wines. The me...

Purpose of Review Parkinson's disease (PD) is characterized by dopaminergic system dysfunction that results from the degeneration of neurons in the substantia nigra. However, studies suggest that other neurotransmitters, especially histamine, may also play a role in the development of PD. Recent Findings Numerous studies show that histamine levels...

Background Hypersensitivity reactions (HSRs) are often encountered in patients receiving paclitaxel infusions. The conventional method, comprising dexamethasone 20 mg (Dex20) taken 12 and 6 hours before paclitaxel plus histamine (H)1 and H2-antagonists administered 30 minutes before paclitaxel, is an effective but cumbersome method in reducing HSRs...

The diversity of allergic disorders and their associated underlying mechanisms render allergy diagnosis particularly challenging. There is a palette of available in vivo and in vitro tests, while result interpretation must always be made in conjunction with clinical history. The focus of the present article is on laboratory diagnostics, where sever...

Histamine is a naturally occurring alkaloid that is an important indicator of meat spoilage, and excessive levels in food can lead to food poisoning or trigger allergic reactions. Therefore, accurate detection of histamine in meat is crucial for evaluating freshness and ensuring meat quality. In this study, a fluorescence probe based on ionic coval...

Mao-tofu is famous for its unique flavour and texture in Anhui Province, China. The physicochemical properties and microbial diversity of Mao-tofu during different fermentation periods were studied. The pH of the tofu was acidic, the moisture gradually decreased, and the hardness, viscosity, and chewiness gradually increased, while the elasticity g...

Background: The four subtypes of G protein-coupled receptors (GPCRs) regulated by histamine play critical roles in various physiological and pathological processes, such as allergy, gastric acid secretion, cognitive and sleep disorders, and inflammation. Previous experimental structures of histamine receptors (HRs) with agonists and antagonists exh...

The vegetable, Telfairia occidentalis Hook (Cucurbitaceae), is useful in Ibibio traditional medicine system for the treatment of various types of diseases such as malaria and gastrointestinal disorders. Antiulcerogenic activity of the stem extract was evaluated against ulcers experimentally-induced in rats. Three doses (200, 400 and 600 mg/kg) of t...

El objetivo de esta investigación fue evaluar diferentes especies de atún y proporciones de migas en el desarrollo de un producto tipo Nuggets. Se utilizó un diseño completamente al azar (DCA) en un arreglo bifactorial 3x3 con tres repeticiones por tratamiento. Se analizaron el contenido de humedad, proteína y grasa de las formulaciones, además de...

Fipronil (FPN) inhibits gamma-aminobutyric acid type A receptors and exhibits strong insecticidal effects. Although FPN’s adverse effects on mammals have been reported recently, few studies have examined subchronic exposure to low doses. We orally administered FPN (0.43 mg/kg) to 4-week-old male mice for 6 wk and assessed their behavior and blood c...

Background Exposure to sweating stimuli triggers transient and severe dermal pain in certain individuals. This study aimed to evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, for the dermal pain induced by sweating stimuli and explored the role of bradykinin in its pathomechanism. Methods This single-blind, randomiz...

Idiopathic epilepsy (IE) is the most common chronic neurological disease in dogs, and a natural animal model for human epilepsy types with genetic and unknown etiology. The microbiota-gut-brain axis (MGBA) is a promising target for improving brain health in individuals where brain function is hampered. It's role in the pathophysiology of epilepsy r...

Kounis syndrome (KS) manifests as an acute coronary syndrome triggered by allergy, hypersensitivity, or anaphylaxis. It is believed that mast cells and histamine can potentially induce acute cardiac events by activating various inflammatory pathways. Here, we present a case of KS triggered by rifampicin administered during empyema drainage in a you...

Background/Objectives: Despite its long-standing recognition, the etiopathogenesis of idiopathic granulomatous mastitis (IGM) remains poorly understood. This study aims to investigate the relationship between IGM and food intolerance, allergies, and immunological factors to shed light on its etiology. Materials and Methods: This case–control study...

Mackerel tuna ( Euthynnus affinis ) has broad appeal in the 5isheries market. Maintaining the quality of 5ish from the Scombridae family is essential for the industry, consumer health, and satisfaction, especially during handling, storage and processing. The Quality Index Method (QIM) is a suitable tool for measuring freshness, its impact on sensor...

Histamine is a significant food quality, safety, and trade issue in the fisheries sector. In the absence of adequate proficiency testing for histamine in India, it was important to organize a proficiency testing (PT) program among 22 food analytical laboratories for the external assessment of proficiency of the laboratories following ISO 17043:2010...

Since the synthesis of histamine in 1907, new reports about its properties and role in the human body have periodically appeared. Its blood levels remain constantly low, almost undetectable, under normal physiological conditions. Increasing histamine levels lead to serious clinical symptoms, including cardiac arrest. Histamine is involved in many p...

Background As traditional laboratory animal use faces ethical and logistical constraints, the chick ileum has been experimented with as an alternate tissue for bioassays, which is crucial for drug discovery and pharmacology education. However, the absence of uniform bioassay protocols for chick ileum presents a significant challenge, impacting the...

Ulcerous lesions can arise in primary skin cancers and upon infiltration of the skin by malignant cells originating from other organs. These malignant fungating wounds are difficult to treat, and they cause pain, itching and malodor. Distressing malodor imposes a major burden on patients. The carrion odor of decaying tissue is—at least in part—due...

Scombridae fish are highly responsible for histamine fish poisoning. Histamine levels are considered a key indicator of fish quality. This study examined histamine variation in selected Scombridae fish; frigate tuna (Auxis thazard), skipjack tuna (Katsuwonus pelamis), and mackerel tuna (Euthynnus affinis) in response to environmental exposure over...

Systemic mastocytosis (SM) is a rare disorder affecting 1 in 10,000 individuals, characterised by abnormal mast cell proliferation in extra-cutaneous organs, resulting in a variety of presentations ranging from mild asymptomatic disease to life-threatening tissue-destructive disease. Severe anaphylaxis caused by the release of histamine from mast c...

We compared the antihistamine effect of four new antihistamines with olopatadine, which is used to treat equine allergic diseases. Six healthy Thoroughbred horses received oral doses of olopatadine (50 mg), levocetirizine (50 mg), bilastine (200 mg), rupatadine (100 mg), and desloratadine (50 mg) at >2-week intervals. The effects were investigated...

Allergic reactions are mediated by histamines, which cause various symptoms like itching, sneezing, and inflammation. Antihistamines are commonly used to counter these effects. Muthuchippi Parpam, a traditional Siddha medicine, has been used for its purported antihistamine properties. This study aims to evaluate the antihistamine activity of Muthuc...

Grape maceration is essential in modulating the quality of Tokaj wines. The aim of this research was to analyse the effect of two maceration practices—one utilizing the application of a Saccharomyces cerevisiae culture and the other being maceration without a yeast culture in experimental Lipovina (Vitis vinifera L.) white wine from the Slovak part...

Background Excessive daytime sleepiness is a common and early symptom of Alzheimer’s disease (AD). The subcortical wake‐promoting neurons in the lateral hypothalamic area, tuberomammillary nucleus (TMN), and locus coeruleus synchronize to maintain wakefulness/arousal. Although significant neuronal decline occurs in wake‐promoting regions, the TMN h...

Mast cells, which originate from the bone marrow, possess the ability to secrete a diverse array of active molecules. These molecules include mediators (histamine, heparin), which have been identified for decades and are stored in specific granules, as well as small molecules generated instantaneously in response to stimulation (membrane lipid deri...

The investigation and isolation of histamine in fish performing microwave-assisted extraction (MAE) and analyzed using liquid and gas chromatography AIP Conf. Proc. (April 2025) Indestructible micro identification of histamine in fish samples using ATR-FTIR spectroscopy AIP Conf. Proc. (April 2025) Determination of histamine using chemical sensor b...

Indestructible micro identification of histamine in fish samples using ATR-FTIR spectroscopy AIP Conf. Proc. (April 2025) Polyurethane-electrode modified to determine histamine in selected samples using chemical sensor AIP Conf. Proc. (April 2025) Determination of histamine using chemical sensor based on amperometric technique using screen-printed...

Allergic rhinitis (AR) is a common in lammatory condition of the nasal mucosa, affecting 10-30% of adults and 40% of children globally. This systematic review assessed the ef icacy and safety of fexofenadine and montelukast, individually and combined, for AR treatment. A literature search using PubMed, Scopus, and Web of Science identi ied 162 stud...

Laut Maluku merupakan salah satu daerah tangkapan ikan tuna dengan produksi yang cukup tinggi, terutama di perairan Maluku Utara. Zona operasi penangkapan ikan tuna di Maluku Utara berada di perairan pulau Bacan, Tidore, Ternate, Obi, Sanana, dan Morotai. Isu pencemaran perairan yang berimplikasi terhadap perikanan karena beberapa jenis polutan ber...

Introduction: Hypertrophic scars, a frequent outcome of abnormal wound healing, can lead to significant disfigurement and functional challenges, with no universally accepted treatment currently available. Research indicates that Musa cavendishii peel extract may play a role in controlling hypertrophic scar formation, though its mechanisms remain un...

Kehamilan mola hidatidosa merupakan salah satu penyebab hipertiroid berat pada kehamilan. Peningkatan sekresi hCG pada kehamilan mola hidatidosa menyebabkan peningkatan hormon kelenjar tiroid T3 dan T4 dan penurunan TSH karena kesamaan struktur dan reseptor TSH dan hCG sehingga mengakibatkan hCG bertindak langsung pada reseptor TSH yang ada di tiro...

This study aimed to identify the predominant bacterial populations in sardine samples with high histamine content (≥ 200 mg*kg-1) and histamine-free (< 1 mg*kg-1). For this study, 1,000 g of muscle samples were collected from 40–45 sardines per batch, all obtained from the same supplier, fishing area and period, for histamine analysis. Samples (1 g...

La investigación tuvo como propósito evaluar los tipos de envase y tiempos de esterilización en el efecto fisicoquímico y microbiológico para pichagua en conservas de aceite de oliva. Se tomaron en cuenta dos factores, el factor A corresponde a los tipos de envases (vidrio y fundas pouch). Mientras que, el factor B a los tiempos de esterilización (...

There is a controversy whether histamine H1-receptor activation raises or lowers or does not affect contractility in the human heart. Therefore, we studied stimulation of H1-receptors in isolated electrically stimulated (one beat per second) human atrial preparations (HAP). For comparison, we measured force of contraction in left atrial preparation...

The work is devoted to the study of the interrelationship between the characteristics of spontaneous electrical activities in paired ureters in norm and after isolation. Analysis was conducted by detecting the amplitude (A), rise rate (V), rise-time (T/2), halfwidth (t), and frequency of rhythmogenesis (F) of pacemaker activity. In norm, the amplit...

Rationale Working memory impairment is a prominent feature of schizophrenia which predicts clinical and functional outcomes. Preclinical data suggest histamine-3 receptor (H3R) expression in cortical pyramidal neurons may have a role in working memory, and post-mortem data has found disruptions of H3R expression in schizophrenia. Objectives We exa...

Despite significant progress in the field of clinical oncology in terms of diagnostic and treatment methods, the results of anticancer therapy are still not fully satisfactory, especially due to limited response and high toxicity. This has forced the need for further research to finding alternative ways to improve success rates in oncological treat...