Hematopoietic Stem Cells - Science topic

Selective depletion of TCRαβ+ and CD45RA+ subsets of apheresed hematopoietic progenitor cells, HPC(A), enables haploidentical hematopoietic stem cell transplant (haplo-HSCT) by circumventing risks of graft-versus-host disease. Here, we analyze our institution’s large series of ex vivo T-cell depletion processes to review procedure performance and e...

The relationship between quasars and their galaxy environment is important for understanding the evolution of galaxies and supermassive black holes, but it is not fully understood. We perform a wide and deep exploration of the environment of quasars at $0.4 < z < 1.0$ using the Hyper Suprime-Cam Subaru Strategic Program (HSC-SSP) survey. We investi...

The ten‐eleven translocation family of enzymes (TET1/2/3) promotes DNA demethylation and is essential for hematopoiesis. While the roles of TET1 and TET2 are well‐studied in hematopoiesis, the requirement of TET3 in embryonic and adult hematopoiesis is less investigated. In this study, by characterizing embryonic and adult hematopoiesis in Tie2+/cr...

Clonal hematopoiesis (CH) refers to the clonal expansion of hematopoietic stem cells caused by somatic mutations. CH is commonly observed in elderly individuals and is closely associated with myeloid malignancies as well as various non-malignant diseases. This study aims to explore the research trends and hotspots of CH using bibliometric analysis....

Sickle cell disease (SCD) is a genetic blood disorder caused by mutations in the hemoglobin gene, leading to abnormal red blood cells that can obstruct blood flow and cause pain and organ damage. While various treatments for SCD have been developed, bone marrow transplantation (BMT) remains the only curative option. However, a limited number of pat...

Elastin stabilization has been correlated with the reversibility of fibrosis. Fibulin-1 can participate in elastin assembly, which promotes its stabilization. However, the role of Fibulin-1 in liver fibrosis remains unknown. Here, we performed a proteomics analysis to identify notable changes in Fibulin-1 expression during continuous fibrosis progr...

The development of engraftable, long‐term reconstituting hematopoietic stem cells (LT‐HSC) from human pluripotent stem cells (hPSC) has been a long‐sought goal. Since HSCs are formed by a subset of endothelial cells in the ventral part of the dorsal aorta, we analyzed heartbeat‐mediated pulsatile displacement experienced by the walls of the dorsal...

High-strength concrete (HSC) and polypropylene fiber-reinforced concrete (PPFRC) as quasi-brittle materials generally experience fracture failure either in mode I (tensile mode) or in mixed mode I and II (tensile and shear), which are the most common forms of damage in structural engineering. This study investigates the fracture behavior of HSC and...

Hematopoietic stem cells (HSCs) are the primitive cells that give rise to common precursors for all blood cell lineages. Abnormalities in their number and/or function are important factors leading to the decline of immune function and the occurrence of various systemic diseases. Phase separation refers to a physicochemical mechanism in which intrac...

Acute Myeloid Leukemia (AML) remains a formidable clinical challenge, predominantly due to the emergence of resistance to existing therapeutic regimens, including BCL‐2 inhibitors like Venetoclax. Here, a novel approach is introduced by engineering BH3 mimetics utilizing non‐canonical amino acids (ncAAs) to achieve dual inhibition of MCL‐1 and BCL‐...

The current study investigated the axial compression behavior of fully encased composite columns (FECC) reinforced with glass fiber reinforced polymer (GFRP) bars. Totally three conventional FEC columns and three FEC columns with the addition of alkali resistant glass fiber (ARGF) made with High Strength Concrete (HSC) are tested under axial compre...

High-strength concrete (HSC) structures offer superior strength and stiffness but are prone to brittleness and premature failure, particularly with strong infill walls. Weak infill in HSC frames aids in stress redistribution and energy dissipation, reducing sudden column shear failure. However, the impact of combined door-window openings on lateral...

Currently, the management of autoimmune disorders still being a challenge in terms of safety, efficiency, and specificity. Cell-based therapeutic strategies have emerged as a novel approach for autoimmune disease treatment, employing different cell therapy platforms, including tolerogenic dendritic cells, regulatory T cells, conventional and regula...

Present-day high strength concrete (HSC) encased steel composite (ESC) columns play a significant role in the construction industry. ESC resists steel sections from corrosion and fire resistance, increasing the load-carrying capacity compared to conventional reinforced concrete columns. This study investigated the behaviour of high-strength concret...

Cytomegalovirus (CMV), a beta-herpesvirus capable of maintaining lifelong latency, presents a substantial risk to transplant recipients, resulting in significant morbidity and mortality among both hematopoietic stem cell and solid organ transplantation recipients. Recent advances have shifted management from reactive approaches, such as preemptive...

Low dose methotrexate (LD‐MTX) remains the gold standard in rheumatoid arthritis (RA) therapy. Multiple mechanisms on a variety of immune cells contribute to the anti‐inflammatory effects of LD‐MTX. Inflammatory signaling is deeply implicated in hematopoiesis by regulating hematopoietic stem and progenitor cell (HSPC) fate decisions; raising the qu...

Hematopoietic stem cell (HSC) fate is shaped by distinct microenvironments termed niches within the bone marrow. Quiescence, expansion, and differentiation are directly and indirectly regulated by complex combinations of cell secretomes, cell‐cell interactions, mechanical signals, and metabolic factors including oxygen tension. The perivascular env...

This paper presents a data-driven modeling methodology based on Explainable Artificial Intelligence (XAI) integrated with Genetic Programming (GP), called XAI-GP, to develop a transparent and practical model for predicting the shear strength of High-Strength Concrete (HSC) beams without shear reinforcement. First, three AI models were trained using...

This phase 2 study evaluated the impact of pegfilgrastim, a single-dose, long-acting granulocyte colony-stimulating factor, on the steady-state mobilization of hematopoietic stem cells into peripheral blood in patients with multiple myeloma (MM) or malignant lymphoma (ML). Efficacy and safety, along with CD34-positive cell mobilization outcomes wer...

Despite its therapeutic potential and unique immunological properties, the immune composition of umbilical cord blood lacks consistent and comprehensive characterizations. Human umbilical cord blood (UCB) is often discarded after delivery and is difficult to obtain for research purposes. Furthermore, most research on UCB is focused on properties of...

Cancer stem cells (CSCs) are hypothesized to promote tumor progression through innate chemoresistance and self-renewal. CSCs reside in the CD34 ⁺ /CD38 ⁻ immunophenotypic subpopulation of acute myeloid leukemia (AML); correspondingly, the size of this subpopulation has a strong negative impact on overall survival. Isolation of CSCs from B-lymphobla...

Background Hematopoietic stem cell (HSC) transplantation is widely recognized as an effective treatment for various malignant diseases. Enhancing HSC mobilization can improve transplantation outcomes and ultimately increase patient survival rates. Recent studies suggest that mild endoplasmic reticulum (ER) stress promotes HSC self-renewal, anti-apo...

Background: Despite the popularity of circuit training and dietary interventions, their combined effects on obese Southeast Asian populations remain underexplored. Objective: This study aims to examine the effects of circuit training (using free weights and body weight) and dietary interventions (low-calorie diet and intermittent fasting using the...

Immunotherapies for acute myeloid leukemia (AML) and other cancers are limited by a lack of tumor-specific targets. Here we discover that RNA-binding proteins and glycosylated RNAs (glycoRNAs) form precisely organized nanodomains on cancer cell surfaces. We characterize nucleophosmin (NPM1) as an abundant cell surface protein (csNPM1) on a variety...

Under stress conditions, such as ex vivo culture, chemotherapy, irradiation and infection, haematopoietic stem cells (HSCs) actively divide to maintain blood cell production. This process leads to production of reactive oxygen species (ROS) that causes HSC exhaustion and haematopoietic failure. Here we show that ferumoxytol (FMT; Feraheme), a Food...

p>The article concerns our experience of psychological assistance for the sibling donors in the course of hematopoietic stem cell transplantation (HSCT) procedure. We discuss psychological support in a case of a 6-year old girl with acute myeloid leukemia and her donor, a 20-year old brother. We describe our experience of communications between cli...

The fetal liver is the primary site for the expansion of hematopoietic stem and progenitor cells (HSPCs) during fetal hematopoiesis. However, the spatial organization of different hematopoietic progenitor populations within the fetal liver remains poorly characterized. In this study, we utilized SeekSpace, a high-resolution single-nucleus spatial t...

In haptic shared control (HSC) for teleoperation, the human operator and autonomous system share control via torque on the input device. When a discrepancy exists between the human's maneuvering intent and the autonomous maneuver presentation, the human can apply additional force to the device to achieve the desired maneuvering. The required force...

Sampling problems demonstrating beyond classical computing power with noisy intermediate-scale quantum devices have been experimentally realized. In those realizations, however, our trust that the quantum devices faithfully solve the claimed sampling problems is usually limited to simulations of smaller-scale instances and is, therefore, indirect....

The magnitude of telomere shortening per cell division in human somatic cells in vivo (MTS IV ) is a fundamental but unquantified parameter. MTS IV is essential for understanding how telomere-length (TL)-dependent hematopoietic cell division influences age-related health and longevity. By leveraging sex differences in leukocyte TL and the different...

Purpose While hematopoietic stem cell transplantation is commonly associated with stem cell procedures in public discourse, “stem cell” remains a broad classification. More precise terminology such as “blood stem cell transplantation”, “bone marrow transplantation”, or “bone marrow stem cell transplantation” may better characterize hematopoietic st...

Philadelphia chromosome-negative myeloproliferative neoplasms (Ph-MPNs) are a group of malignant clonal disorders originating from bone marrow hematopoietic stem cells, and pulmonary hypertension (PH) is a serious progressive disease often coexisting with Ph-MPNs, with a prevalence ranging from 5 to 50%. The aim of this study was to analyze the pre...

Background Erythroid cells can be generated from hematopoietic stem and progenitor cells (HSPC) derived from various sources; however, few studies decode ex vivo human erythropoiesis for the discrepancies at single-cell multi-omics resolution and uncover the underlying restraints for erythrocyte regeneration. Results We deciphered ex vivo human er...

Clonal hematopoiesis (CH) is an early indicator of hematologic malignancies, driven by mutations in hematopoietic stem cells (HSCs) such as TET2 or TP53. Mutations in ZBTB33 have been implicated in MDS and suggested as a potential driver of CH. However, the role of ZBTB33 in hematopoiesis and its involvement in CH remains unclear. We generated a Zb...

Clonal haematopoiesis arises when a haematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type HSCs, resulting in its clonal expansion. Individuals with clonal haematopoiesis are at increased risk of developing haematologic neoplasms and other age-related inflammatory illnesses1, 2, 3–4. Suppressing the e...

Megakaryocytes (MKs), the precursor cells of platelets, have essential roles in a variety of pathophysiological processes in the bone marrow (BM) niche. Megakaryocytes maintain hematopoietic stem cell microenvironment through inflammatory and immunological responses. The primary objective of this research was to investigate the clinical impact of B...

Peripheral blood stem cell (PBSC) donation is the primary procedure used to collect haemopoietic stem cells (HSCs) for transplantation in individuals with haematological malignancies. More than 90,000 HSC transplants take place globally each year, and there is an increasing need to guarantee HSC mobilisation, improve tolerability to apheresis, and...

Mitochondrial quality control (MQC) is a critical mechanism for maintaining mitochondrial function and cellular metabolic homeostasis, playing an essential role in the self-renewal, differentiation, and long-term stability of hematopoietic stem cells (HSCs). Recent research highlights the central importance of MQC in HSC biology, particularly the r...

In seismically active areas, the structural integrity of structures is significantly reliant on the efficacy of beam-to-column connections. This study investigates the potential of high-strength concrete (HSC) and engineered cementitious composites (ECC) as alternatives to conventional transverse reinforcements to alleviate joint congestion and enh...

The gut biome, a complex ecosystem of micro- and macro-organisms, plays a crucial role in human health. A disruption in this evolutive balance, particularly during early life, can lead to immune dysregulation and inflammatory disorders. ‘Biome repletion’ has emerged as a potential therapeutic approach, introducing live microbes or helminth-derived...

This case report showed a 60-year-old male with Pemphigus foliaceus (PF), complicated by hypertension, diabetes, and hepatitis B, for whom traditional treatments posed potential risks. The regimen included prednisone, human umbilical cord mesenchymal stem cells (UC-MSCs), and apremilast, showing several advancements: UC-MSCs addressed PF and comorb...

Structural loads are generally the forces affecting any structural element, and these loads are taken into account when designing according to the type of structure. In general the loads are divided into static and dynamic. The research studies the effect of dynamic load on the concrete slabs. In the practical part, six different types of concrete...

Background/Objectives: In 2020, 595 million world citizens had osteoarthritis, and the largest growth in OA morbidity refers to the hip joint. Effective OA therapies have been sought for years. Assessing the treatment effectiveness and QoL improvement in hip OA after intra-articular administration of fresh peripheral blood hematopoietic CD34+ stem...

Dust-obscured galaxies (DOGs) are considered to be in a co-evolution phase, with the associated active galactic nuclei (AGN) obscured by dust and gas. Although the DOGs are thought to harbor rapidly growing SMBHs, their X-ray statistical properties, crucial for understanding the properties of obscuring gas as well as the accretion disk state and th...

The origin of lambda Boo stars is currently unknown. After several efforts by many authors, no bona fide lambda Boo stars have been confirmed as members of open clusters. Their detection could provide an important test bed for a detailed study of lambda Boo stars. Results. For the first time, we present the surprising finding of two lambda Boo star...

ABSTRACT The thesis aims to examine the impact of English competence on the performance of the BBA students. In order to measure the effect of English competence on different subjects at the university level, primary data were collected from the students of Premier University through questionnaires. The questionnaires were administered to 115 unde...

Dissecting the preneoplastic disease states’ biological mechanisms that precede tumorigenesis can lead to interventions that can slow down disease progression and/or mitigate disease-related comorbidities. Myelodysplastic syndromes (MDS) cannot be cured by currently available pharmacological therapies, which fail to eradicate aberrant hematopoietic...

MicroRNA (miRNA), a significant class of regulatory non-coding RNA (ncRNA), can regulate the expression of numerous protein-coding messenger RNAs (mRNAs). miRNA plays an important part in shaping the human transcriptome. So far, in the human genome, about 2500 miRNAs have been found. Acute myeloid leukemia (AML) belongs to a malignant clonal disord...

Rhododendron nymphaeoides belongs to the Fortunea subsection of the Rhododendron genus. Despite being officially listed as an endangered species (with the conservation status of EN) by the International Union for Conservation of Nature Red List, The Red List of Rhododendrons, Red List of China's Higher Plants, and the Threatened Species List of Chi...

Launched by NI Health Minister in 2020, the goal of the HSC Industry Partnership Agreement is to develop and accelerate improvements to the health and wellbeing of patients affected by conditions under the care of the HSC System who are from all over the UK although predominantly from Northern Ireland. Subsequently, our findings will be shared to b...

Background and Aim Portal myofibroblasts (PMF) are known to be critical in bile duct injury, but their role in liver fibrogenesis remains underexplored. Thy‐1, an adhesion molecule detected as soluble Thy‐1 (sThy‐1) in serum, is primarily expressed by portal myofibroblasts (PMF) and, to a lesser extent, hepatic stellate cells (HSC), serving as a ma...

Introduction: We need to change how we plan, manage, and deliver our health and wellbeing services in Northern Ireland to meet the changing demands of our population and improve outcomes - ICS NI is our opportunity to do things differently. ICS NI provides a new commissioning framework, one built on partnership and collaboration within Health and S...

Hematopoietic stem cells (HSCs) sustain lifelong haematopoiesis as their progeny differentiate into all blood cell lineages. Homeostatic HSCs are mostly quiescent and only rarely divide, however their proliferation and differentiation rates can be modulated by external factors. Acute and chronic infections from a wide range of pathogens are known t...

The South Eastern Health & Social Trust (SET) provides a service to a population of over 350,000. Central to improving health & wellbeing and contributing to reducing health inequalities is innovation, service improvement and excellence by working in partnership and collaboration both internal and external to the organisation. The SET Outdoors Serv...

Malignant transformation of gene modified haematopoietic stem cells caused anxiety following adverse events in early clinical trials using gamma-retroviral vectors (γRV) to correct haematopoietic stem cells (HSC) in monogenic immune disorders. Adoption of HIV-derived lentiviral vectors (LV) with SIN (self-inactivating) configurations greatly reduce...

This study primarily investigated the mechanism and pathways of the cPLA2α signaling pathway on Th17-mediated HSC activation and liver fibrosis, providing insights for clinical strategies to target HSC activation and delay the rapid progression of liver fibrosis. In vitro and in vivo model were established, and different concentrations of the cPLA2...

We present the largest prospective real-world experience in 159 patients who received the triple combination of tacrolimus/sirolimus/mycophenolate mofetil after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-alloHSCT) from matched-related (MRD), matched-unrelated (MUD) or mismatched-unrelated donors (MMURD)....

Toxoplasmosis is a parasitic, foodborne infection caused by Toxoplasma gondii. The infection can be transmitted through various routes, including the following: (i) the consumption of vegetables, fruits, or drinking water containing sporulated oocysts; (ii) the consumption of raw or undercooked meat; (iii) transmission from mother to fetus; (iv) th...

The c-MPL receptor is known to be involved in the development of AML conditions. The function of c-MPL is mostly regulated by the crosstalk and stoichiometry of its different isoforms. Though expression of c-MPL in AML cases is studied, the regulation of these isoforms, their balance and mechanism of action in conditions like AML needs to be reveal...

Mycosis fungoides (MF) is a major variant of primary cutaneous T-cell lymphoma (CTCL) characterized by infiltration of neoplastic T cells in the epidermis and dermis. This disease progresses gradually and rarely reaches an advanced stage. Once advanced, MF is nearly impossible to treat due to limited therapeutic options. However, allogeneic hematop...

Background Ageing-associated remodeling of the murine B cell system is accompanied with a reduction of CD19⁺ B cells such as follicular B cells (FOB) and an accumulation of age-associated B cells (ABC) or activated B cell subsets. This remodeling is thought to confer an attenuated antibody response, such as to SARS-CoV-2 spike (S) vaccines in both...

Our goal is to understand how hematopoietic stem cell precursors emerge from vessels and to visualize their settling in developmental and more definitive niches that will persist in the adult. For this, we use as a biological model the zebrafish, which offers invaluable advantages owing to its transparency and small size, allowing high-resolution i...

Background: Low-density lipoprotein cholesterol (LDLc) is regarded as a risk factor for endothelial dysfunction. However, LDLc stimulates the proliferation of hematopoietic stem cells (CD34-positive cells), which contribute to endothelial repair. Therefore, LDLc may have a beneficial influence on the endothelium of individuals with lower endothelia...

This study focuses on optimizing resilience strategies for interdependent infrastructure networks (e.g., electric power, water supply, transportation system) against intelligent attacks. We formulate this problem as a tri-level defender-attacker-defender (DAD) model, which is known for its computational complexity. To address this challenge, we pro...

The purpose of the study was to investigate the impact of heated hemp seed cake and phytase enzyme inclusion into the diet on the mineral content of the tibia and femur in broiler chickens. Unsexed Ross broiler chicks (210 birds) were randomly allocated into 7 treatments and 6 replicates and reared for 42 days. The treatments were P1= diet based on...

Background Bone marrow (BM) suppression is the most prevalent dose-limiting side effect of chemotherapy and radiotherapy. Exposure to ionizing radiation (IR) results in acute BM suppression and long-term BM injury. Gasdermin E (GSDME) is crucial for mediating apoptosis and pyroptosis during chemotherapy. However, its role in radiation-induced hemat...

Myeloproliferative neoplasms (MPNs) are clonal stem cell disorders characterized by dysregulated megakaryopoiesis and neoplastic hematopoietic stem cell (HSC) expansion. Using a murine model with MK-specific JAK2V617F expression, we establish an MPN aging model where mutant MKs drive HSC expansion and a progressive decline in wild-type HSC function...

By the mid-1960s, hematopoietic stem cells (HSCs) were well described. They generate perhaps the most complex array of functionally mature cells in an adult organism. HSCs and their descendants have been studied extensively, and findings have provided principles that have been applied to the development of many cell systems. However, there are unce...

As hematological tumor patients are surviving long-term, the long-term toxicities of therapeutic regimens have become increasingly evident. The coexistence of two hematological tumors in the same patient is extremely rare and typically shows an aggressive clinical course and unsatisfactory prognosis. In the present case, we describe the case of a 6...

With the increasing use of CRISPR–Cas9, detecting off-target events is essential for safety. Current methods primarily focus on guide RNA (gRNA) sequence mismatches, often overlooking the impact of DNA topology in regulating off-target activity. Here we present TOPO-seq, a high-throughput and sensitive method that identifies genome-wide off-target...

Objective The aim of this study is to identify therapeutic cargos within mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) for the treatment of liver fibrosis, a condition that poses significant health risks. Results sEVs from human umbilical cord-derived MSCs (UCMSCs) and their differentiated hepatocyte-like cells (hpUCMSCs)...

Introduction Alcoholic liver disease poses a severe threat to human health. The thyroid hormone Triiodothyronine (T3) is closely related to liver metabolism. This study investigated the effect and mechanism of T3 in alcoholic liver injury. Methods Acute alcoholic liver injury model was established in mice by alcohol administration. Alcoholic liver...

The National Education Policy (NEP, 2020) emphasizes enhancing school education quality, fostering transparency, and ensuring continuous self-assessment for institutional improvement. The School Quality Assessment and Assurance Framework (SQAAF) is a structured evaluation system designed to align with NEP 2020's vision of school accreditation and d...

We present the weak-lensing mass calibration of 124 galaxy clusters and groups at redshift $0.1<z<0.8$ in the first Data Release of the $eROSITA$ All-Sky Survey ($eRASS1$) and constrain their BCG stellar-mass-to-halo-mass-and-redshift relation, using the data sets from the Hyper Suprime-Cam (HSC) Subaru Strategic Program. The cluster survey is cond...

Rapid hematopoietic adaptations are important for building and sustaining the biological response to β-glucan. The signals involved in these early events have not yet been fully explored. Given that type I interferons are produced in response to β-glucan and can profoundly impact hematopoietic stem cell (HSC) function, we hypothesized that this pat...

The utilization of alternate reinforcement materials to improve footing capacity performance has garnered significant interest in recent years. Limited research has been conducted to understand the impacts of basalt reinforcement. This study aims to investigate the performance of the high-strength concrete (HSC) footing reinforced by alternative ma...

div class="section abstract"> Electrified powertrains, including Power Splits (Electrically Variable Transmissions), Range Extenders (Series Hybrids), and Electric Vehicles with Disconnect Actuators, offer significant flexibility in managing input actuator acceleration and output torque, drawing power from shared sources. The Hybrid Supervisory Con...

As global life expectancy continues to rise, the prevalence of age-related conditions like cardiovascular diseases (CVDs), neurodegenerative diseases (NDs), and chronic inflammation is also on the rise. These diseases are closely tied to the aging process, which is more accurately assessed through biological age than chronological age alone. Hemato...

Humans encounter ionizing radiation (IR) through various ways, such as medical applications, agricultural industry, and potential exposure from radioactive materials or acts of radiological terrorism. Hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) are crucial for maintaining the balance of blood cell lineages. The hematop...

C3G, a Rap1 GEF, promotes megakaryopoiesis and platelet function. Using transgenic and knock-out mouse models targeting C3G in megakaryocytes, we investigated whether C3G also affects the niche function of megakaryocytes during bone marrow (BM) recovery after myeloablation induced by 5-fluorouracil (5-FU), or total body irradiation (TBI) followed b...