HRD - Science topic

Objective To explore the horizontal impact of extensive incisor retraction on alveolar bone and to investigate the relationship of changes in alveolar bone thickness (ΔBT) with horizontal retraction distance of the incisal edge (HRD) and horizontal retraction distance of alveolar ridge crest (HRD’) in orthodontic treatment. Materials and methods T...

Introduction Homologous recombination deficiency (HRD) is a key biomarker in the management of high-grade serous ovarian cancer (HGSOC), guiding treatment decisions, particularly regarding the use of poly(ADP-ribose) polymerase inhibitors (PARPi). As multiple HRD assays are available, each with distinct methodologies and cutoff values, the interpre...

Background The clinical background of cancer patients is complex, and the efficacy and safety of different poly (ADP-ribose) polymerase inhibitors (PARPis) vary greatly. Therefore, we conducted a systematic review and network meta-analysis to compare the efficacy and safety of the six PARPis and systematically evaluated the differences in PARPis in...

Background PARP inhibitors are effective in treating ovarian cancer, especially for BRCA1/2 pathogenic variant carriers and those with HRD (homologous recombination deficiency). Concerns over toxicity and costs have led to the search for predictive biomarkers. We present an updated systematic review, expanding on a previous ESMO review on PARP inhi...

Background: Climate change and sustainability challenges compel organizations to incorporate sustainable environmental principles into their operational framework. Green Human Resource Development (Green HRD) is a strategic paradigm that emphasizes training, developing, and empowering personnel to advocate for sustainability initiatives. Objective:...

Many HRD interventions aim to enhance self‐awareness to shape employee behavior, to develop skills, or as a performance‐related outcome. But measuring this development faces significant metacognitive challenges: self‐awareness changes when one's attention is directed to it, and self‐report relies on accurate self‐awareness. To address this issue, w...

The need for skilled foreign workers in South Korea (Korea hereafter) has grown substantially due Korea's changing workforce demographics, skill mismatch, transformation of business portfolios, and the pursuit of globalized business. As a result, large Korean companies have begun to recruit highly educated foreign workers for global talent manageme...

Background Homologous recombination deficiency (HRD) refers to the dysfunction of homologous recombination repair (HRR) at the cellular level. The assessment of HRD status has the important significance for the formulation of treatment plans, efficacy evaluation, and prognosis prediction of patients with ovarian cancer. Objectives This study aimed...

The targeting of cancer stem cells (CSCs) has proven to be an effective approach for limiting tumor progression, thus necessitating the identification of new drugs with anti-CSC activity. Through a high-throughput drug repositioning screen, we identify the antibiotic Nifuroxazide (NIF) as a potent anti-CSC compound. Utilizing a click chemistry stra...

ERK, a coveted proliferation drug target, is a pivotal kinase in the Ras/ERK signaling cascade. Despite this, crucial questions about its activation have not been fully explored on the foundational, conformational level. Such questions include (i) Why ERK's activation demands dual phosphorylation; (ii) What is the role of each phosphorylation site...

The integrity of p53 machinery is crucial for platinum activity, while p53 mutation is frequent in high-grade serous ovarian cancer (HGS-OC). This study aimed to evaluate the link between p53 mutations, platinum sensitivity (PS), and the platinum-free interval (PFI) in patients with HGS-OC. We prospectively analyzed 159 consecutive women with ovari...

Tujuan dari penelitian ini adalah untuk menguji hubungan antara HRD dan employee engagement yang berkaitan dengan niat keluar di kalangan karyawan bank-bank BUMN di Jakarta. Tingginya tingkat niat karyawan untuk keluar menjadi pendorong penelitian ini, yang berusaha memahami peran HRD dan employee engagement dalam fenomena ini. Dengan 130 partisipa...

Accurate visualization and quantification of homologous recombination (HR)-associated foci in readily available patient samples are critical for identifying patients with HR deficiency (HRD) when they present for care to guide polyADP ribose polymerase (PARP) inhibitors (PARPi) or platinum-based therapies. Immunofluorescence (IF) assays have the po...

Although hybrid work has increased and is here to stay, organizations are still experimenting with the design and the appropriate interventions required. Evidence is emerging that the well-being and employee engagement of staff has declined in hybrid work and it is necessary to understand this as a critical priority for HRD professionals. This stud...

This article explores expatriate and repatriate career progress on career ladder and lattice paths through the theoretical lenses of career construction theory, chaos theory of careers and the career ladder versus career lattice model. The research method is an exploratory, qualitative study, using purposive sampling and snowball sampling technique...

Phishing is a social engineering attack which intends to steal information from an intended victim by masquerading as a reputable source. It is a ubiquitous problem in modern day society and organizations, which is not likely to slow down. The Big Five psychological factors model is one which is widely used and has been shown to largely explain how...

The responsiveness of Human Resource Information Systems (HRIS) as alternative enablers that assist several sectors in achieving competitiveness is significant. The necessity for Human Resource Department (HRD) performance in the healthcare sector often leads to several investigations conducted. Surprisingly, the advantage of HRIS influence in heal...

The use of poly(ADP-ribose) polymerase inhibitors (PARPi) revolutionized the treatment of BRCA-mutated cancers. Identifying patients exhibiting homologous recombination deficiency (HRD) has been proved useful to predict PARPi efficacy. However, obtaining HRD status remains an arduous task due to its evolution over the time. This causes HRD status t...

School of Management Sciences (SMS) Lucknow (India), established in 2008 and approved by AICTE, Ministry of Education, Government of India New Delhi has been accredited with A+ Grade by National Assessment and Accreditation Council (NAAC).SMS Lucknow offers quality education in the areas of Management and Technology offering BBA, BCA, B. Com, B. Co...

Abstract At the turn of the century, human resource development (HRD) scholars and scholar-practitioners speculated about the future performance of artificial intelligence (AI) to be able to perform intellectual tasks in manners that were less expensive, more effective, and must faster (Gold, Rodgers, & Smith, 2003). Responsibilities of team membe...

Abstract In 2020, few businesses had adequately prepared for the possibility of a global pandemic. The resulting economic fallout was devastating, with over 200,000 U.S. businesses permanently shutting down (Cox, 2021)—a stark reminder to business executives the critical importance of scenario planning in navigating unforeseen crises and ensuring...

Abstract Systematic literature reviews (SLR) have become a primary methodology accepted in the medical sciences and have expanded into other disciplines. This expansion has met with some fundamental complications as these formats are not completely transferrable across disciplines. The format for conduction a SLR in one discipline is different from...

Background Although the combined treatment with radiopharmaceutical therapy (RPT) and poly (ADP-ribose) polymerase inhibitors (PARPi) shows promise, a critical challenge remains in the limited quantitative understanding needed to optimize treatment protocols. This study introduces a mathematical model that quantitatively represents homologous recom...

This study presents a comprehensive analysis of the research landscape in learning-related AHRD-sponsored articles using bibliometric analysis and topic modeling techniques. A total of 490 peer-reviewed articles published between 2005 and 2024 were examined to identify the intellectual structure, thematic landscape, and emerging trends. The bibliom...

ENOPH1 (Enolase-phosphatase 1), a member of the HAD-like hydrolase superfamily, has been linked to a range of physiological conditions, including neurological disorders. However, its involvement in tumorigenesis remains underexplored. This study is the first to conduct a pan-cancer analysis of ENOPH1, aiming to elucidate its role in multiple cancer...

Background: High-grade advanced ovarian, fallopian tube, and primary peritoneal (HGAOC) cancers require both surgical and systemic treatment. The introduction of polyADP-ribose polymerase inhibitors (PARPis) has significantly improved outcomes. This study presents an analysis of HGAOC patients treated at a single center, following updated guideline...

This conceptual paper discusses the impact of neoliberal ideology on Human Resource Development (HRD). We explain the ways through which neoliberalism, as a politicaleconomic ideology, has influenced the HRD literature. We postulate a particular focus on instrumentality and individualistic self-reliance. Through a methodical review of the literatur...

Background Venadaparib, a novel poly (ADP‐ribose) polymerase (PARP) inhibitor, has demonstrated high PARP‐1/2 selectivity over other PARP family members and exhibited strong PARP‐trapping activity, effectively inhibiting tumor growth in homologous recombination deficient (HRD) cancer in vitro and in vivo. Methods This phase 1, dose‐finding study e...

Luminous blue variables are an intermediate stage in the evolution of high-mass stars characterized by extreme mass loss and substantial variability. The stars show large irregular episodic variations on timescales of years to decades in these stars' effective temperatures (called "S Dor variations"). Observations show that these variations are tri...

Background Intraductal Carcinoma of the Prostate (IDC-P) is a significant prognostic indicator for prostate cancer, which demonstrates significant associations with homologous recombination repair gene mutations (HRRm) and alterations in tumor suppressor genes. However, no study in Japan has investigated the association between IDC-P and genetic mu...

Kinerja karyawan merupakan faktor krusial dalam keberhasilan organisasi. Motivasi dan lingkungan kerja menjadi dua aspek yang berpengaruh dalam meningkatkan produktivitas karyawan. Tujuan penelitian ini guna menginvestigasi apakah motivasi dan lingkungan kerja berpengaruh terhadap kinerja karyawan pada RA SHOP. Populasi penelitian ini sebanyak 56 r...

In this predominantly photometric study, we investigate various types of photometric and physical instabilities in the yellow hypergiant (YHG) ρ Cas as well as its evolution between 1885 and 2023. The second yellow hypergiant we study is YHG HR 8752, which recently became stable. The other two yellow hypergiants are HR 5171A and HD 179821. We const...

Background Combination of chemotherapy and immunotherapy is the current standard of care for advanced endometrial cancer. However, survival outcome remains poor, highlighting the urgent need for new treatments and reliable tools to identify patients who will benefit from them. Patient-Derived Tumor Organoids (PDTO) are three-dimensional structures...

Background Along with BRCA mutation status, homologous recombination deficiency (HRD) testing is a prognostic and predictive biomarker for poly-ADP-ribose polymerase (PARP) inhibitor therapy indication in high-grade epithelial ovarian, fallopian tube, or peritoneal cancer. Approximately 50% of high-grade serous ovarian cancers exhibit HRD, even in...

Introduction Pseudomyxoma Peritonei (PMP) is an extremely rare disease characterized by progressive accumulation of mucinous ascites and implants in the peritoneum. We investigated the prognostic value for response to cytoreductive surgery (CRS) or hyperthermic intraperitoneal chemotherapy (HIPEC) and dissected potential beneficial targeted therapy...

Background Neomorphic isocitrate dehydrogenase (IDH) mutations lead to the accumulation of 2‐hydroxyglutarate (2‐HG), an oncometabolite implicated in tumor progression via inhibitory effects on alpha‐ketoglutarate. Moreover, mutant IDH–dependent accumulation of 2‐HG results in homologous recombination deficiency (HRD), which preclinically renders t...

We aimed to create a NK cell marker genes-based signature to predict immunotherapy response and prognosis in colorectal cancer. We integrated scRNA-seq data from four Gene Expression Omnibus (GEO) samples and performed Weighted gene correlation network analysis (WGCNA) based on 587 the Cancer Genome Atlas (TCGA) colorectal cancer samples to uncover...

Recently, homologous recombination deficiency (HRD) has become a new target for hereditary cancers. Molecular-based approaches for hereditary cancers in the clinical setting have been reviewed. In particular, the efficacy of the PARP inhibitor has been considered by several clinical trials for various kinds of hereditary cancers. This indicates tha...

Objectives In order to improve the accuracy and efficiency of data acquisition for cochlear structure, this study built an intelligent segmentation and automatic measurement model of cochlear based on U-HRCT to solve the difficulty of performing an accurate preoperative evaluation of the cochlea. Methods The data of 86 patients (172 ears in total)...

PARP-inhibitors (PARPi) are an integral part of ovarian cancer treatment. However, overcoming acquired PARPi resistance or increasing the benefit of PARPi in patients without homologous recombination deficiency (HRD) remains an unmet clinical need. We sought to identify genetic modulators of PARPi response, guiding pharmacological PARPi sensitizati...

Responding to a growing focus on identity within academia and the shifting socio-economic landscape, this study investigates the role of identity in executive coaching. Given identity’s complexity, its impact on human thriving, and its critical role in HRD, this research examines how coaches perceive, engage with, and address identity-related issue...

PT.Rentang Buana Niagamakmur atau sering dikenal dengan PT.RBN adalah perusahaan yang berfokus pada produksi dan pemasaran furniture di area Priangan Timur. Dalam pengangkatan karyawan kontrak menjadi karyawan tetap, perusahaan ini memiliki standar acuan penilaian dengan kriteria antara lain: Masa Kerja, Pencapaian Hasil Kerja, Kreativitas, Kedisip...

Plant resistance to pathogens can be significantly enhanced through genetic modification, thereby reducing the reliance on chemical pesticides. CONSTITUTIVE EXPRESSER OF PATHOGENESIS‐RELATED GENES 5 (CPR5) serves as a key negative regulator of plant immunity. Here we explored the functional domains of the CPR5 protein with the goal of dampening its...

PT Integra Inovasi Indonesia adalah perusahaan konsultan dan pengembang yang menangani masalah dan kebutuhan teknologi informasi dengan fokus pada pemanfaatan IT yang efisien untuk meningkatkan kinerja dan performa. Tahap penting dalam pengembangan sumber daya manusia adalah memilih calon karyawan; teknik yang digunakan di PT Integra Inovasi Indone...

PT Dina Mika Muda Mandiri is a logistics and transportation company that is facing challenges in recruiting outsourced employees to meet the company's standards with complex assessment criteria. In overcoming this problem, the research developed a decision support system that is integrated with Rest API and the Fuzzy Technique for Order Preference...

Współczesne organizacje funkcjonują w warunkach niepewności, zmienności i złożoności, określanych mianem środowiska VUCA (Volatility, Uncertainty, Complexity, Ambiguity). W czasie wystąpienia przedstawiliśmy interdyscyplinarne podejście do zarządzania kryzysowego i rozwoju zasobów ludzkich, podkreślając znaczenie przywództwa rezylientnego, elastycz...

Backgrounds Protocadherin gamma subfamily B, 7 (PCDHGB7), a member of the protocadherin family, plays critical roles in neuronal connections and has been implicated in female reproductive system cancers. Its function in lung cancer has not been elucidated. Methods We comprehensively investigated PCDHGB7 expression, prognosis, biological function,...

Background The homologous recombination deficiency (HRD) test is an important tool for identifying patients with epithelial ovarian cancer (EOC) benefit from the treatment with poly(adenosine diphosphate-ribose) polymerase inhibitor (PARPi). Using whole exome sequencing (WES)-based platform can provide information of gene mutations and HRD score; h...

Background PARP inhibitors (PARPis) have shown promising effectiveness for ovarian cancer. This network meta-analysis (PROSPERO registration number CRD42024503390) comprehensively evaluated the effectiveness and safety of PARPis in platinum-sensitive recurrent ovarian cancer (PSROC). Methods Articles published before January 6, 2024 were obtained...

Background: Approximately half of ovarian high grade serous carcinomas (HGSC) have homologous recombination deficiency (HRD). However, HRD is not well characterized in Black individuals. Objective: To characterize HGSC HRD by self reported race and evaluate whether differences in HRD are associated with ovarian cancer mortality. Study population: C...

Oncogene activation in normal untransformed cells induces DNA replication stress and creates a dependency on DNA Damage Response (DDR) mechanisms for cell survival. Different oncogenic stimuli signal via distinct mechanisms in every cancer setting. The DDR is also pathologically re-programmed and deployed in diverse ways in different cancers. Becau...

Patients with High-Grade Serous Ovarian Cancer (HGSOC) exhibit varied responses to treatment, with 20-30% showing de novo resistance to platinum-based chemotherapy. While hematoxylin-eosin (H&E)-stained pathological slides are used for routine diagnosis of cancer type, they may also contain diagnostically useful information about treatment response...

Purpose This study compared the outcomes of haploidentical-related donor (HRD) and umbilical cord blood (UCB) hematopoietic stem cell transplantation (HSCT) in pediatric patients with hematologic malignancies. Methods Data on patients who underwent HRD HSCT with post-transplant cyclophosphamide ( n = 41) and UCB HSCT ( n = 24) after targeted busul...

Background Double-strand breaks (DSBs) are primarily repaired through non-homologous end joining (NHEJ) and homologous recombination (HR). Given that DSBs are highly cytotoxic, PARP inhibitors (PARPi), a prominent class of anticancer drugs, are designed to target tumors with HR deficiency (HRD), such as those harboring BRCA mutations. However, many...

Context . With the PLAnetary Transits and Oscillation of stars (PLATO) space mission set for launch in December 2026 by the European Space Agency (ESA), a new photometric legacy and a future of new scientific discoveries await the community. By exploring scientific topics outside of the core science program, the PLATO complementary science program...

This study aimed to evaluate the ability of a hydraulic resistance device (HRD) to assess the force and power output and force-velocity-power profile of short sprints, while examining the effects of hydraulic overload on these outcomes. Twenty-eight amateur athletes performed 20 m sprints under minimal (MiL), moderate (MoL), and high (HiL) overload...

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with poor prognosis and limited treatment options. While the majority of PDAC cases harbor KRAS mutations, approximately 8%–10% are KRAS wild‐type (KRAS‐WT). These KRAS‐WT tumors often contain actionable mutations and gene fusions, making them more suitable for precision therapies....

Promosi kenaikan jabatan adalah proses peningkatan posisi atau jabatan seorang karyawan dalam suatu organisasi atau perusahaan. Proses ini biasanya melibatkan perpindahan karyawan dari satu tingkat pekerjaan ke tingkat yang lebih tinggi, disertai dengan peningkatan tanggung jawab, otoritas, dan umumnya kompensasi Penelitian ini berfokus pada implem...

Background LIGHT (oLaparib In HRD‐Grouped Tumor types; NCT02983799) prospectively evaluated olaparib treatment in patients with platinum‐sensitive relapsed ovarian cancer (PSROC) assigned to cohorts by known BRCA mutation (BRCAm) and homologous recombination deficiency (HRD) status: germline BRCAm (gBRCAm), somatic BRCAm (sBRCAm), HRD‐positive non‐...

Objectives Emerging data have shown that local treatment could provide clinical benefit for non-small cell lung cancer (NSCLC) patients with oligometastasis. Liver metastases have the worst prognosis in advanced NSCLC, but the genomic characteristics of liver oligometastasis remain unclear. The aim of our study was to elucidate the molecular featur...

It is observed that the global burden of diseases had shifted from infectious diseases to Non-Communicable Diseases (NCDs), with an accumulative trend in developing countries. NCDs share key modifiable behavioral risk factors like unhealthy diet and lack of physical activity that are typically established during adolescence or young adulthood and w...

Androgen-indifferent prostate cancer (AIPC) is increasingly common and particularly lethal. Data describing these tumors are sparse, and AIPC remains a poorly understood malignancy. Utilizing the Oncology Research Information Exchange Network (ORIEN) database, we enriched for tumors with features of AIPC using previously described characteristics....

Aims: To explore physician-reported knowledge, use, and perceptions of genetic testing for advanced ovarian cancer management. Materials & methods: Gynecology/oncology specialists (n = 390) in the US, Europe, Canada, Japan, and Australia completed an online survey spanning March 2021 to April 2022. Results: Physician-reported breast cancer gen...

Context. Typical uncertainties of ages determined for single star giants from isochrone fitting using single-epoch spectroscopy and photometry without any additional constraints are 30-50 %. Binary systems, particularly double-lined spectroscopic (SB2) binaries, provide an opportunity to study the intricacies of internal stellar physics and better...

There is an urgent need of precision medicine for ovarian cancer patients to identify patients who respond to chemotherapy and PARP inhibitors, a therapy targeting homologous recombination deficiency (HRD). Here we established a panel of 37 long-term patient-derived tumor organoids (PDTO) models of various histological subtypes from 224 patients an...

Introduction: Massive Open Online Courses (MOOCs) are an agile context for workplace training, which can provide physicians with needed knowledge and skills related to their clinical practice. From an organisational standpoint, their effectiveness can be assessed on physicians’ intention to transfer what they learn through them in the workplace. De...

Through the use of quantitative research methodology and data collection techniques including observation, interviews and recording, this research seeks to determine and assess the influence of work-life balance and job crafting on employee performance at PT.XYZ. Head of the HRD Department of PT XYZ and karyawan acted as informants for data collect...

RING Finger 187 (RNF187) has recently emerged as a potential contributor to tumorigenesis. However, a comprehensive pan-cancer analysis of RNF187 in human tumors has not been undertaken until now. Our study aims to investigate RNF187 expression across 33 different types of human tumors, utilizing data from the TCGA and GTEx databases. The pan-cance...

PT Langgeng Jaya Plastindo adalah perusahaan manufaktur yang mengkhususkan diri pada produk plastik daur ulang, mengedepankan inovasi dan keberlanjutan. Penelitian ini bertujuan untuk mengevaluasi efektivitas program talent pool perusahaan dalam meningkatkan pengembangan karir, mengatasi inefisiensi dalam seleksi kandidat, dan mencapai efisiensi bi...

Introduction This study predicted HRD score and status based on intra- and peritumoral radiomics in patients with ovarian cancer (OC) for better guiding the use of PARPi in clinical. Methods A total of 106 and 95 patients with OC were included between January 2022 and November 2023 for predicting HRD score and status, respectively. Radiomics featu...

Genomic analysis has played a significant role in the identification of driver mutations that are linked to disease progression and response to drug treatment in ovarian cancer. A prominent example is the stratification of epithelial ovarian cancer (EOC) patients with homologous recombination deficiency (HRD) characterized by mutations in DNA damag...

Background: Genomic data is essential for clinical decision-making in precision oncology. Bioinformatic algorithms are widely used to analyze next-generation sequencing (NGS) data, but they face two major challenges. First, these pipelines are highly complex, involving multiple steps and the integration of various tools. Second, they generate featu...

Penelitian ini bertujuan untuk meneliti bagaimana prosedur sistem informasi akuntansi penggajian serta penyimpangan yang terjadi pada sistem informasi akuntansi penggajian pada CV. Jati Motor Gowa. Sumber data diperoleh dengan cara wawancara dan observasi. Data sekunder didapatkan dari dokumen terkait sistem penggajian pada CV. Jati Motor Gowa. Met...

Penelitian ini bertujuan untuk mengukur kompetensi karyawan di departemen PPIC pada salah satu perusahaan pupuk swasta di Kabupaten Gresik serta meluncurkan proses rekrutmen dan seleksi yang ada. Dengan pendekatan deskriptif kualitatif, penelitian ini mengumpulkan data primer melalui wawancara mendalam dengan HRD, Leader PPIC, dan karyawan dengan m...

Background Ovarian cancer (OvC) constitutes significant management challenges primarily due to its late-stage diagnosis and the development of resistance to chemotherapy. The standard treatment regimen typically includes carboplatin and paclitaxel, with the addition of poly (ADP-ribose) polymerase inhibitors for patients with high-grade serous ovar...

Tujuan dari makalah ini adalah melaporkan hasil dari wawancara yang kelompok kami lakukan dengan Manajer HRD PT Bersama Selaras Beritikad yang dimana untuk membahas seputar SDM disebuah perusahaan. Makalah ini didasarkan atas studi literatur dari sumber-sumber tersediadan didasarkan pada hasil wawancara dari kelompok kami kepada Manajer HRD PT Bers...

Tujuan dari makalah ini adalah untuk memberikan gambaran yang jelas mengenai langkah- langkah yang diambil PT. Raya Mulia dalam melakukan rekrutmen dan pelatihan karyawan, serta bagaimana proses-proses tersebut berkontribusi terhadap peningkatan kualitas SDM dan keberhasilan perusahaan.

Tujuan dari makalah ini adalah melaporkan hasil dari wawancara yang kelompok kami lakukan dengan Manajer HRD PT Bersama Selaras Beritikad yang dimana untuk membahas seputar SDM disebuah perusahaan. Makalah ini didasarkan atas studi literatur dari sumber-sumber tersediadan didasarkan pada hasil wawancara dari kelompok kami kepada Manajer HRD PT Bers...

The primary goal of this research is to identify the key HRD practices that link organizational commitment and user predictability. The study employs causal-comparative research design and positivism epistemology. An analysis of associations' effects is done using a cross-sectional survey questionnaire. There were 46508 employees in the survey, and...

Background: Ovarian cancer (OC) is the 9th most prevalent cancer overall in India and the 3rd most common among women, following breast and cervical cancers. According to GLOBOCAN 2022, there were 47,333 new OC cases and 32,978 deaths. Epithelial ovarian cancer (EOC) represents 90% of OC cases, of which 70% are high-grade serous ovarian cancer (HGS...

Ecotourism is a form of tourism that can help overcome the problem of low welfare of local communities. The digital cultural transformation that occurred in the era of revolution 4.0, especially during the COVID-19 pandemic, was able to change the entire cycle of the tourism ecosystem. Besides, several ecotourism experiences have experienced a sign...

Community empowerment is an important issue that can improve the welfare of individuals and communities. This approach needs to be implemented in villages, especially those aimed at empowering communities through human resource development, especially in Jabung Village. Human resource development (HRD) in the context of community empowerment in Pon...

In the face of increasingly intense competition in the business world, quality human resources (HR) are the main factor for companies to survive and compete. In this case, the workforce is an important asset owned by the company and has a big role in determining the company's success. Human resource development (HRD) is a crucial element for compan...

This trioethnographical study explores the influence of relational mentoring in developing the identities of three international Asian women scholars from different career stages within the field of human resource development (HRD) in the United States. By capturing our voices through personal narratives drawn from our day‐to‐day lived experiences,...

The overexpression of Polo-like kinase 1 (PLK1) is associated with poor clinical outcomes in various malignancies, making it an attractive target for anticancer therapies. Although recent studies suggest PLK1’s involvement in homologous recombination (HR), the impact of its overexpression on HR remains unclear. In this study, we investigated the ef...

Human Resource Development (HRD) is one of the main priorities in realizing the progress of a region. The Human Development Index (HDI) is one of the indicators used to measure the quality of HRD. This study aims to analyze the quality of HRD in Gorontalo Province using the HDI as the main indicator. Secondary data from the Central Statistics Agenc...