Granulocytes - Science topic

Background Septic cardiomyopathy (SCM) is a prevalent complication of sepsis and a primary contributor to mortality in patients with sepsis. Although fatty acid metabolism (FAM) is known to regulate cardiac function, its specific role in the pathogenesis of SCM remains unclear. Methods The SCM datasets were obtained from the NCBI GEO database. Dif...

A 4-year-old, male, intact African pygmy hedgehog was presented at the clinic with a 2-day history of weakness. Clinical examination revealed a large fluid-like mass, suspected to be the urinary bladder. The surveying ultrasound confirmed an enlarged urinary bladder with anechoic content and a small amount of floating echoic material. The patient w...

The aim of this study was to explore the prognostic value of mean corpuscular volume (MCV) in newly diagnosed aplastic anemia (AA) patients treated with cyclosporine A (CsA) plus androgen or CsA alone. The clinical data of 181 newly diagnosed patients with aplastic anemia from April 2008 to September 2020 in the Affiliated Hospital of Xuzhou Medica...

Background Prognosis after salvage allogeneic hematopoietic cell transplantation (HCT) in refractory myeloid malignant diseases is poor with no standard of care. Methods A prospective single‐arm study was conducted to evaluate if a combination of posttransplantation bendamustine and cyclophosphamide (PTBCy) facilitates augmented graft‐vs‐leukemia...

BCR::ABL1-positive chronic myelogenous leukemia (CML) presents with a typical phenotype in over 95 percent of cases. These are associated with a p210kDa oncoprotein (M-bcr genotype). In these cases, the consideration of CML is high on the differential diagnosis list and appropriate genetic studies to confirm the BCR::ABL1 oncogene are de rigueur. T...

Characterization and classification of invertebrate hemocytes is a powerful tool for determining the physiological effect of environmental stress. Hemocytes from four decapod crustacean species Dilocarcinus pagei, Zilchiopsis collastinensis, Aegla uruguayana and Macrobrachium borellii were analyzed by flow cytometry followed by morphological charac...

Whether granulocytes for transfusion are beneficial remains uncertain, although some evidence suggests that efficacy may be dose-related. Granulocytes are mostly produced by apheresis procedure, but other means of production are increasingly used. Centers that produce and/or use granulocytes were recruited through the BEST Collaborative and complet...

Anaplasmosis remains a significant threat to livestock production in tropical regions, particularly in the Amazon basin, where ecological complexity and limited veterinary infrastructure challenge effective disease management. This review focuses on Anaplasma marginale and Anaplasma phagocytophilum, the primary species associated with bovine and gr...

Aims This study aimed to investigate the trends in pediatric inflammatory bowel diseases (IBD) management in Japan over the past decade. Methods We retrospectively analyzed data from Japan's nationwide database from 2012 to 2022. Patients aged ≤ 15 years diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) were included. Trends in the us...

Pulmonary alveolar proteinosis (PAP) is a rare lung disease caused by accumulation of surfactant in the alveoli, leading to debilitating respiratory symptoms and impaired gas exchange. The recent European Respiratory Society guidelines provide evidence-based recommendations for its diagnosis and management. Autoimmune PAP (aPAP) is the most common...

The Phase Angle (PhA) and water cell distribution ratios are essential indicators of inflammation linked to serum inflammatory markers. We aim to investigate the relationship between PhA and extracellular water to total body water (ECW/TBW) ratio with hematological inflammatory markers. The study utilized data from the PERSIAN Organizational Cohort...

Recent advancements in digital pathology have enabled comprehensive analysis of Whole-Slide Images (WSI) from tissue samples, leveraging high-resolution microscopy and computational capabilities. Despite this progress, there is a lack of labeled datasets and open source pipelines specifically tailored for analysis of skin tissue. Here we propose Hi...

Objectives Diffuse large B-cell lymphoma (DLBCL) is a common and highly aggressive type of lymphoma. Iron metabolism plays a critical role in human diseases, however, which remains unclear in DLBCL patients. The study is to explore the genetic characteristics and molecular mechanisms underlying ferroptosis in DLBCL patients. Methods Based on the G...

During an infection, prostaglandin E2 (PGE2) mediates immune responses in insects and later epoxyoctadecamonoenoic acids (EpOMEs) are produced from linoleic acid to suppress excessive and unnecessary immune responses. Intracellular signaling pathway by which these oxylipins suppress the immune responses was previously unclear. This study demonstrat...

Objective Evaluating pesticides’ impacts on human health, ecological balance, and agricultural production is the main focus of research on pesticides. The present study aims to investigate the hematological parameters of both genders of albino rats after exposure to dimethoate pesticides. Material and Methods There was a total of eight groups of a...

Lumpy skin disease (LSD) is a serious disease of cattle. The study was conducted to explore the potential protective effect of Oxytetracycline and Vitamins A, D and E on hematological alterations induced by lumpy skin virus in clinically infected animals. Significant changes were observed in the percentages of white blood cells (WBC), granulocytes...

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intense pruritus. The principal pathological features include abnormalities in the structure and function of the epidermis, as well as skin inflammation marked by the overexpression of T helper 2 cell (Th2) cytokines. Throughout the progression of AD, various immune cell...

Aging of hematopoietic and immune system (HIS) leads to cellular senescence and immune dysregulation, contributing to age-related diseases. Here, we show that Procyanidin C1 (PCC1), a compound with both senolytic and senomorphic properties, can counteract aging-related changes in HIS. Using single-cell RNA sequencing and validation experiments, we...

Hemorrhagic Cystitis is an inflammation accompanied by bleeding that occurs in the urinary bladder characterized by thickening of the urinary bladder wall and has clinical symptoms of hematuria or urine with blood, dysuria, abdominal distension and pain when palpated in the abdominal area. Patients with symptoms of weakness, loss of appetite and vo...

Background Hematopoietic stem transplantation (HSCT), from matched related donors (MRD) is offered as a curative therapeutic option in children with Sickle cell disease (SCD). Objective We wanted to assess the outcome and long terms complications observed in children undergoing HSCT at a single transplant center in Saudi Arabia. Patients and Method...

Background The number of studies on the effect of smoking cessation interventions in polycythemic patients is limited. Our aim was to examine the effects of quitting smoking on hematological parameters in patients with polycythemia and to evaluate the outcomes of smoking cessation interventions in polycythemic patients. Methods The prospective stu...

Wells syndrome, a rare eosinophilic cutaneous disorder, also called eosinophilic cellulitis, exhibits significant clinical heterogenicity. It typically presents as erythematous infiltrated plaques, primarily on the extremities. Initially, these lesions often exhibit similarities to erysipelas or cellulitis but do not respond to antimicrobial therap...

Mitochondrial-associated granulocyte macrophage colony-stimulating factor (Magmas) is a unique protein located in the inner membrane of mitochondria, with an active role in scavenging reactive oxygen species (ROS) in cellular systems. Ovarian cancer (OC), one of the deadliest gynaecological cancers, is characterised by genomic instability, affected...

It is well established that the early inflammatory response following fracture is essential for initiating subsequent bone regeneration. An imbalance in inflammation, whether within the innate or adaptive immune response, can result in impaired fracture healing. In our previous studies, we demonstrated that, for example, mice with ovariectomy-induc...

Background: Ischemic stroke is considered a fatal ischemic disease with high mortality and morbidity. Acute ischemic stroke is a cascade of inflammatory reactions, which not only causes vascular degeneration but also leads to neurological disorders. During this period, the rapid response of neutrophil-dominated granulocytes releases cytokines and c...

Toxoplasmosis is a significant food-borne protozoal disease in humans and animals. The study aimed to find out Toxoplasma seropositivity in sheep, estimate epidemiological risk factors and assess haemato-biochemical parameter changes. Blood samples were collected from 276 indigenous sheep in five districts surrounding Sulaymaniyah Province in the n...

The immune system of neonatal calves is immature and highly susceptible to diseases, which poses significant challenges to their survival. This study aimed to evaluate the immune response of calves during the first 30 days of life, focusing on leukogram analysis, T lymphocyte immunophenotyping (CD3+, CD4+, and CD8+) via flow cytometry, and cytokine...

Background: White blood cell malignancy is known as chronic myelogenous leukemia (CML), or chronic myeloid leukemia. This type of leukemia is defined by the buildup of myeloid cells in the blood and their uncontrollably elevated proliferation in the bone marrow. A proliferation of adult granulocytes (neutrophils, eosinophils, and basophils) and the...

The classification of microscopic blood cell images is a vital component in medical diagnostics, as accurately identifying different cell types is crucial for diagnosing a range of hematological conditions. Traditional Convolutional Neural Networks (CNNs) are used for this goal due to their effectiveness in extracting spatial features. However, the...

The article is devoted to the study of the general immunological resistance of the body of male futsal athletes at the age range of 13-14 years, who are in the V critical period of the formation of the immune system in the process of training and those who do not play futsal. Research methods: The study involved young futsal players of the Futsal A...

Background Although, COVID-19 has resulted in over 7 million deaths globally, many questions still remain about the risk factors for disease severity and the effects of variants and vaccinations over the course of the pandemic. To address this gap, we conducted a retrospective analysis of electronic health records from COVID-19 patients over 2.5 ye...

Background Vaccinia virus (VACV) and mpox virus (MPXV) belong to the orthopoxvirus genus and share high genetic similarity, making VACV widely used in the mpox pandemic. CAST/EiJ mice have been widely used for studying orthopoxvirus infection. However, the histopathological features of CAST/EiJ mice with mpox virus (MPXV) and vaccinia virus (VACV)...

The etiopathogenesis and treatment response of sensitive skin remain poorly understood. We used 4-tert-butylcyclohexanol (4-TBLH) and 1% pimecrolimus ointment to treat sensitive skin in mice models constructed using tape stripping, propylene glycol, and capsaicin. This study aimed to further investigate the sensitivity and responsiveness of this se...

Background/Objectives: Peptide Receptor Radionuclide Therapy (PRRT) is approved for patients with inoperable, progressive and/or metastatic well-differentiated NETs. Before the approval of Lutathera®, locally manufactured ¹⁷⁷Lu-HA-DOTATATE was used on a regular basis in clinical routine. The aim of this study was (1) to compare the hematotoxicity o...

Monomethyl fumarate (MMF) and its prodrug dimethyl fumarate (DMF) are currently the most widely used agents for the treatment of multiple sclerosis (MS). However, not all patients benefit from DMF. We hypothesized that the variable response of patients may be due to their diet. In support of this hypothesis, mice subjected to experimental autoimmun...

Background Sepsis is an organ dysfunction that impairs response to infection. Inflammatory biomarkers have been used to diagnose and monitor sepsis. The aim of the present study was to determine the role of immature granulocytes (IGs) in monitoring sepsis treatment. Methods This two-center, prospective, observational study included patients diagno...

Introduction : Transfusion-related acute lung injury (TRALI) is a life-threatening syndrome that occurs within six hours of a blood transfusion. Materials and methods :The objective of this study was to investigate the characteristics, clinical manifestations, outcomes, and risk factors of TRALI in patients who underwent surgery at a single medical...

Introduction: Acute febrile illness contributes to significant morbidity and death particularly in tropical country such as Indonesia. The symptoms are nonspecific, therefore distinguishing these pathogens is difficult without additional laboratory tests. The extended white blood cell parameters indicate cell activities induced by immune response t...

Polychaetes (Phylum Annelida) respond to sensory stimuli through the usage of sensory organs and appendages, such as palps, which vary in shape and structure depending on lifestyle. The typical palps of nereidid polychaetes are tapered appendages constituted by two articles. The palpophore is the wider and longer basal article, followed by the thin...

Objectives Currently, there exist two approaches to the treatment of malignant neoplasms: the Karanahan technology and in situ vaccination, which are based on chronometric delivery of therapeutic agents to the tumor depending on the characteristics of tumor cells, as well as the immune status. The main purpose of this study was to experimentally pr...

Background Contributions of leukocytes to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) defense have been reported extensively. However, it remains unclear whether there are different leukocyte responses to ancestral SARS-CoV-2 and its variants. Methods We analyzed peripheral blood leukocyte and subtype concentrations from 575 COVID...

Vibriosis, caused by Vibrio parahaemolyticus, is a major bacterial disease in shrimp aquaculture, often managed with antibiotics that contribute to antimicrobial resistance and environmental concerns. This study investigated the antimicrobial properties of Kiam wood (Cotylelobium lanceotatum) extract and its potential as a dietary supplement to enh...

Inflammatory cardiovascular diseases are the leading cause of death worldwide. Neutrophils, key drivers during inflammation, have consistently been associated with adverse outcomes and mortality in cardiovascular pathologies. Given the uniquely high plasticity and turnover of neutrophils, we profiled the appearance of distinct neutrophil maturation...

Background Diabetes significantly heightens risks of COVID-19 infection, and vaccine hesitancy remains high due to safety concerns. Material/Methods This study assessed the effects of inactivated COVID-19 vaccine in 548 diabetic patients from Tianjin, China, categorized by vaccination status: unvaccinated (n=94), primary immunization (n=117), and...

The treatment of chronic neutropenias and control of neutropenia‐related infections remain challenging topics for pediatric and adult hematologists. This article aims to fill the gap in the treatment of neutropenias and, in combination with the previously published European guidelines on diagnosis of neutropenias, gives complete and comprehensive g...

Phagocytes, including granulocytes (especially neutrophils), monocytes, macrophages, and dendritic cells, are essential components of the innate immune system, bridging innate and adaptive immunity. Their activation and function are tightly regulated by transcription factors that coordinate immune responses. Among these, Krüppel-like factor 4 (KLF4...

Cryptococcosis is a disease originating in the lungs, often seen in immunosuppressed patients. In severe cases, it can lead to meningoencephalitis and can be fatal. Biochemical studies have shown that the capsule of Cryptococcus neoformans is predominantly composed of glucuronoxylomannan (GXM), with glucuronoxylomannogalactan (GXMGal) present in sm...

There are few reports examining the effects of simultaneous administration of multiple killed lactic acid bacteria with different physiological properties to fish. In this study, we fed three heat‐sterilized lactic acid bacteria, Lactobacillus delbrueckii (Lac‐b‐d), Leuconostoc mesenteroides (Leu‐m), and Lactococcus lactis (Lac‐c‐l), either singly...

Mastitis remains the most prevalent and costly disease to dairy producers. Granulocytes are the primary host innate immune cell responders during infectious mastitis. Here we examine three mid-lactation Holsteins challenged with ~ 150 CFU of Staphylococcus aureus (Newbould) that developed chronic mastitis as assessed by bacteria and somatic cell co...

The goal of our research was the investigation of the immunological indicators levels that reflect the phagocytic and bactericidal activity of leukocytes in leptospirosis.Materials and methods. The blood samples of 62 patients with leptospirosis were examined. The cytological method was used for determination of the phagocytic indicator, the cytoch...

Eosinophils represent a granulocyte cell type that is strongly associated with type 2 inflammatory conditions. During steady state conditions few eosinophils are found in lung tissue, though they may contribute to homeostasis. In allergic airway inflammation, eosinophils are strongly increased and associated to disease severity. The underlying type...

Background Although phobia is a common psychiatric disorder, the underlying biological mechanisms have not been fully elucidated. Complex immune-brain interactions that affect neural development, survival, and function may have causal and therapeutic implications in psychiatric illnesses. In this study, the relationships between immune cell traits...

Background. Currently, an active search for ways to increase the effectiveness of alloplasty of ventral hernias in experimental and clinical directions is ongoing, however, structural and functional changes in scar tissue during its reorganization, as well as the state of muscular-aponeurotic, microvascular and connective tissue components in the p...

The results of adjuvant combined systemic therapy of low-grade angiosarcoma in domestic animals are presented. The study subjects were cats (n = 3) and one dog with a morphologically confirmed diagnosis. All animals underwent surgical resection of the formation along the marginal boundaries, followed by histological examination of the surgical mate...

Case 1 involved a 34-year-old woman who had been diagnosed with Crohn’s disease (CD) at 30 years old. After deciding to discontinue CD treatment, she was diagnosed with moderate flare-up of CD based on disease activity and endoscopic findings. Inadequate response was seen 7 days after starting oral prednisolone (PSL) at 30 mg/day, so combination th...

The host complement system is a critical component of innate immunity and serves as a principal mechanism of pathogen defense in mammals. EP67 is an engineered decapeptide derived from the C terminus of human complement protein C5a, which displays selective immunostimulatory activity. EP67 preferentially activates phagocyte mononuclear cells but sh...

A 5-year-old boy affected by chronic granulomatous disease (CGD) underwent two allogeneic hematopoietic cell transplants (HCT) from the same unrelated donor. The first HCT was complicated by prolonged fever and primary graft failure. While fully aplastic, the patient developed a disseminated infection by Scedosporium apiospermum involving the knee...

Background Fine particulate matter (PM2.5) exposure has been associated with adverse effects on reproduction, yet the underlying cellular mechanisms remain poorly understood. Methods Using single-cell RNA sequencing, we systematically investigated cell cycle dynamics of immune cell populations in the mouse uterus following PM2.5 exposure. Analysis...

Keywords: Granulocytic Cells; Pluripotent Cells; Hippocampus Circuit This research deals with application of stem cell and neuron formation and neuron cell generation after damage and lead to the neuron cell formation. Stem cell theory It says that each cell is a clone of other cell but not exact due to defects in DNA. • DNA act as a architecture f...

Objective. This case report describes a young female who developed agranulocytosis with blast cells in peripheral blood following prolonged metamizole use after ankle surgery. Case Report. A 17-year-old female patient was admitted to the Department of Infectious Diseases due to high fever and sore throat. Initial diagnostics revealed agranulocytosi...

Liquid biopsies are becoming increasingly used for the detection and monitoring of disease states. While cell free DNA (cfDNA) in blood and urine have been well studied, much less is known about the composition of cfDNA in seminal fluid. We sought to characterize cfDNA in seminal fluid through tissue of origin studies using methylation analysis in...

This study investigates the variations in hematological parameters, including white blood cell (WBC) count, lymphocyte percentage (LYM%), granulocyte percentage (GRA%), and platelet indices, within a sample dataset. The WBC count ranged widely, with higher counts potentially indicating infection or inflammation, while lower counts suggested immune...

Breed-specific variations in immune responses have been studied across various species and breeds. The identification of camel breeds with high immune competence can enhance the breeding of camels with superior immune responsiveness. To date, no study has examined the immune cell composition in the blood of the Omani camel breed. The present study...

Introduction. Considering the decisive role of antibacterial strategies of secretory degranulation and NETosis in the prevention of sepsis, it is of interest to study the interaction of Yersinia pestis with human blood granulocytes using an ex vivo bacteremia model to assess the effectiveness of this antibacterial strategy of the host organism in p...

Neutrophils are a granulocytic population of myeloid cells that have critical effector functions during infectious disease but are generally thought to be short-lived and nonproliferative with markedly limited activation states. In these studies, we directly compared lung neutrophil activation following infection with different groups of pathogens...

The study was conducted to investigate the effect of selenium nanoscale in improving the utilization of high wheat bran diet using 15 Awassi ewes weighing 51.58 ± 1.71 kg and their ages ranged between 3-4 years, the ewes were divided into three groups, each group included five ewes, the ewes were fed during the study period, which amounted to 72 da...

Rheumatic Heart Disease (RHD) remains a significant health burden, particularly in regions with scarce healthcare resources, research on its immunological aspects remains insufficient. This study employed a two-sample Mendelian Randomization approach, utilizing GWAS data from the largest available datasets for gut microbiota and immune cells as exp...

Preeclampsia (PE), a major cause of maternal and perinatal mortality with highly heterogeneous causes and symptoms, is usually complicated by gestational diabetes mellitus (GDM). However, a comprehensive understanding of the immune microenvironment in the placenta of PE and the differences between PE and GDM is still lacking. In this study, cytomet...

Physical exercise can have acute or short-term effects on immunological overnight recovery. Concurrent training (CT) is an often-applied exercise regime in team (e.g., soccer) and individual sports (e.g., judo, rowing) characterized by high training volumes and/or intensities. CT can be programmed in different sequencing schemes including strength/...

Background Renal fibrosis is a hallmark of progressive chronic kidney disease (CKD), with emerging evidence linking gut microbiota dysbiosis to disease progression. Myeloid-derived suppressor cells (MDSCs) have demonstrated renoprotective effects, yet the impact of fecal microbiota transplantation (FMT) on MDSC-mediated modulation of renal fibrosis...

Background Large bone defects resulting from trauma, disease, or resection often exceed the intrinsic capacity of bones to heal. The current gold standard addressing these defects is autologous bone grafting (ABG). Procedures such as reamer–irrigator–aspirator (RIA) and conventional bone grafting from the iliac crest are widely recognized as highly...

Myeloproliferative neoplasms are clonal hematological neoplasms characterized by excessive proliferation of cells of erythroid, granulocytic, and megakaryocytic lineage. The genetic mechanisms underlying this group of blood diseases are now known, but new perspectives have recently emerged in the field of epigenetics and particularly related to the...

Semaphorin3E has shown promise in alleviating the severity of asthma in preclinical studies; however, its role in the chronic features of type 2-low asthma remains unclear. Therefore, we aimed to investigate the role of Sema3E in a mouse model of severe asthma that exhibits a mix of granulocytic inflammation with neutrophils dominance and compared...

Malaria, the leading global health burden, affects approximately 247 million people annually, with increasing resistance to conventional antimalarial drugs like chloroquine and artemisinin posing critical challenges. This study evaluates the antiplasmodial efficacy of combined aqueous extracts of Carica papaya and Tithonia diversifolia on Plasmodiu...

Thiamine, crucial for energy metabolism, is associated with various human diseases when deficient. We studied how variations in the SLC19A3 gene, encoding THTR2, a thiamine transporter, may influence type 2 diabetes (T2DM) and gout (arthritis urica, AU). We characterized the SLC19A3 gene variants using bioinformatics and analyzed DNA samples from c...

Hematopoiesis is a complex process that begins with hematopoietic stem cells (HSCs) that progressively differentiate into all the cellular components found in blood. Numerous cell states exist along this continuum and alterations along the differentiation trajectory can lead to disorders, including hematopoietic neoplasms. Dogs are a valuable model...

Objective Immunomodulatory treatment options for multiple sclerosis show an inverse risk‒benefit ratio of side effects and treatment efficacy. Although rare, anti-B-cell therapies can cause acute or late-onset neutropenia. Methods We report a case of severe recurrent fluctuating neutropenia after ofatumumab treatment. Results We observed four rec...

Glucocorticoids regulate hematopoiesis, but how chronic elevation of endogenous glucocorticoid production affects hematopoietic stem cell (HSC) function and immune cell development remains incompletely understood. Using an adrenocortical cell-specific HIF1α (Hypoxia inducible Factor-1α)-deficient mouse model (P2H1Ad.Cortex) resulting in elevated gl...

Background Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is crucial for treating high-risk hematological cancers. Posttransplant infections are a leading cause of mortality and morbidity, especially before engraftment. This study evaluated the effects of granulocyte transfusion (GT) therapy on neutrophil and platelet (PLT) engraftm...

Background COVID‐19 exhibits a variety of symptoms and may lead to multi‐organ failure and death. This clinical complexity is exacerbated by significant immune dysregulation affecting nearly all cells of the innate and adaptive immune system. Granulocytes, including eosinophils, are affected by SARS‐CoV‐2. Objectives Eosinophil responses remain po...

Introduction Varicella-zoster virus (VZV) affects over 90% of the global population. The initial encounter with VZV, often in the early years of childhood, results in varicella. From latency, VZV can reactivate in later stages of life, leading to the development of herpes zoster. Considering the importance of host immune responses in preventing rea...