Glucosamine - Science topic

Kdo (3‐Deoxy‐d‐manno‐oct‐2‐ulosonic acid) is an essential sugar found in bacterial lipopolysaccharides with significant biomedical relevance. This study introduces an orthogonally protected 3‐iodo‐Kdo fluoride donor and demonstrates its coupling to a pre‐synthesized β‐(1→6)‐linked N‐acetylglucosamine disaccharide acceptor as an example. Nuclear mag...

RESUMO Este estudo analisa a epidemiologia dos Transtornos Mentais Relacionados ao Trabalho (TMRTs) no estado de Goiás entre 2019 e 2023. A pesquisa foi motivada pelo aumento da conscientização sobre a importância da saúde mental, especialmente no ambiente de trabalho, onde o estresse e a competitividade exacerbam a incidência de transtornos como a...

Aromatase inhibitors (AI’s) are effective adjuvant treatments for postmenopausal patients with hormone receptor-positive breast cancer. However, AIs are often associated with diffuse joint and muscle pain, referred to as aromatase inhibitor-associated musculoskeletal syndrome (AIMSS), the symptoms of which are associated with negative impacts and r...

E QUE TAL UMA ESCAPADINHA AO CARTAXO? Para mim foi um verdadeiro teste o conseguir ver interesse num Concelho que já foi o mais populoso do Ribatejo, depois de Santarém, mas que tarda em encontrar nova via de progresso. Justifica-se a visita a um Concelho que nem possui um posto de turismo? A resposta está no final. JORNADA 7-CONCELHO DO CARTAXO A...

Background Glucosamine is a widely used supplement for treating osteoarthritis and joint pain. New evidence suggests a potential association between glucosamine and type 2 diabetes, inflammation and cardiometabolic risk. We aimed to prospectively evaluate the association of habitual glucosamine use with risk of diabetic microvascular complications...

Osteoarthritis (OA) is a chronic, progressive disease that affects bones and joint structures. Osteoarthritis is associated with joint pain, cartilage degradation, synovial inflammation, subchondral bone remodeling and osteophyte formation. It mainly impacts the knees, hips, hands, and lumbar spine. Despite its high prevalence, no current treatment...

Resumo Este artigo surgiu de uma etnografia que buscou compreender a relação das pombogiras com as pessoas através da noção do acerto, enquanto conceito do próprio campo. Essa etnografia foi possível, a partir do encontro com Dona Padilha, Dona Mulambo, Dona Maria e Dona Sete Saias nas giras. Esta pesquisa é, também, um acerto construído com as pom...

Spanish American literature vividly depicts various cowboy archetypes, each illustrating distinct cultural identities and regional traits. This article explores the portrayals of cowboys—gauchos in Argentina, llaneros in Colombia and Venezuela, vaqueros and charros in Mexico, huasos in Chile, and morochucos in Peru—across notable literary works. Th...

Glukosamina merupakan senyawa penting untuk menjaga kesehatan sendi. Saat ini, hampir seluruh kebutuhan glukosamina di Indonesia masih bergantung pada impor. Pengembangan produksi glukosamina dengan variasi konsentrasi HCl menjadi langkah strategis untuk memenuhi kebutuhan nasional. Penelitian ini bertujuan untuk menentukan konsentrasi HCl terbaik...

o xasco que va donà una guapa valenciana a set galans pretendents que volian conquistar-la [1r] Vaig a contar-vos un cas mol graciós y divertit, sens afegir-hi una coma del modo que ha ha succehit. Era una valencianeta casada ab un jornalé, que hi havia prop d'un any qu'estaba sense fe re. Com era ben axerida y tenia bufó el cos més de quatre papan...

O artigo busca evidenciar a trajetória de Dona Ivone Lara na saúde mental e no samba. Ela atuou como enfermeira e assistente social no Rio de Janeiro até se aposentar do trabalho em hospital psiquiátrico. Foi também parceira da psiquiatra Nise da Silveira no uso das expressões artísticas junto aos internos. A partir da revisão integrativa da litera...

Proterochampsidae is a clade of archosauriform reptiles that lived during the Triassic Period, with notable fossil records in South America. Among these, Ladinian deposits in Brazil have yielded the oldest proterochampsids worldwide, offering insights into the origins of the group. However, their record from this interval remains scarce, with only...

This paper discusses possible changes to the machine-actionable Data Management Plans specification and ecosystem of services to enable compatibility with the FDO architecture, as defined by the DONA foundation.

Over the last few decades, a variety of programs and policies has been defined and implemented for providing housing for low-income people. Among these plans, Mehr Housing Plan, which has been done in recent years by the government, can be seen widely in this field. During the last 5 years, the project in collaboration with various organizations in...

Tricholoma matsutake, as a rare wild edible mushroom, is popular due to its unique flavor and taste, as well as high nutritional and economic value. Investigating the relationship between the complex structure and in vitro immunological activity of TMP-2a, a novel polysaccharide isolated from T. matsutake, was the aim of this study. The results sho...

O objetivo do estudo versa em descrever a utilização do Espaço não Formal institucionalizado "Usina Hidrelétrica” como alternativa pedagógica para o Ensino de Ciências no Ensino Fundamental. O estudo, de abordagem qualitativa, foi desenvolvido com alunos do 9º ano do Ensino Fundamental II de uma Escola Municipal de Ensino Fundamental, no centro do...

Ground-based global navigation satellite system (GNSS) and remote sensing interferometric synthetic aperture radar (InSAR) techniques have proven to be very useful for deformation monitoring. GNSS provides high-precision data but only at a limited number of points, whereas InSAR allows for a much denser distribution of measurement points, though on...

To explore the therapeutic efficacy of L-glutamine (L-Gln) on pathological progression and clinical symptoms of osteoarthritis (OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB). Rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting from the fifth week after sham operation or Anterior Crucia...

The purpose of this study entitled "Mental Health of Junior High School Teachers in Relation to Work Performance: Basis for Intervention" was to examine the mental health of junior high school teachers in relation to their work performance for School Year 2021-2022. A Survey Questionnaire for Mental Health was administered to 164 respondents Junior...

rmonaliyeva Madinaxon O'ktamovna 1 dotsent, TDAU universiteti, 2 katta o'qituvchi TDAU universiteti, 3,4 Toshkent davlat agrar universiteti Ipakchilik va tutchilik yo'nalishi 1-bosqich talabasi https://doi.org/10.5281/zenodo.14906490 Annotatsiya. Ushbu maqolamizda respublikamiz sharoitida yetishtirilayotgan tutchilik xo'jaliklardagi nihollarni agro...

Este texto busca analisar representações do gênero feminino na Enciclopédia Thesouro da Juventude, no período de 1911 a 1927, tempo compreendido pelo primeiro fragmento encontrado no Brasil e pela coleção aqui pesquisada. Teoricamente operou-se com as noções de representação de Chartier (1990), e gênero, segundo Arruda (2002), a partir da questão-p...

Background Aspergillus fumigatus, the primary etiological agent of invasive aspergillosis, causes over 1.8 million deaths annually. Targeting cell wall biosynthetic pathways offers a promising antifungal strategy. Gfa1, a rate-limiting enzyme in UDP-GlcNAc synthesis, plays a pivotal role in the hexosamine biosynthetic pathway (HBP). Results Deleti...

Background Hypoxic-ischemic encephalopathy (HIE) is a leading cause of neonatal mortality and morbidity, yet no validated biomarkers currently exist to predict long-term outcomes. We investigated the potential of the neonatal urinary metabolomic profile as a predictor of long-term neurodevelopmental outcomes in HIE newborns treated with therapeutic...

Beevor's sign in a novel GNE myopathy

O presente artigo tem por objetivo narrar a história de vida da Dona Augusta, a partir das suas relações com o campo e a educação. Para o desenvolvimento da pesquisa, de abordagem qualitativa, utilizei a história de vida que tem por objetivo apreender e compreender a vida conforme o indivíduo relata e interpreta. Para contar a história de vida da D...

Introduction Ulcerative colitis (UC) is a chronic disease that requires pharmacological therapy to achieve remission. This study aimed to evaluate the effect of glucosamine selenium (GASe) on chronic colitis and reveal the underlying regulatory mechanisms. Methods We evaluated the cumulative toxicity of GASe by gavage in mice for 40 days. Dextran...

Rotaviruses (RVs) are the main cause of viral diarrhea among infants, small children, and the young of many animal species. Histo-blood group antigens (HBGAs) are potential RV receptors and glycan composition on mucous surfaces influences host susceptibility and cross-species virus transmission. RVs exhibit genotype-dependent glycan binding and dif...

Background Knee osteoarthritis (KOA) stands as a prevalent clinical condition that frequently affects individuals. A growing body of research has highlighted the potential advantages of dietary supplements, including glucosamine and chondroitin, in the management of KOA. Purpose This study aims to ascertain the most efficacious dietary supplement...

Osteochondral defects are common orthopedic conditions that can lead to osteoarthritis and severe joint pain. Recently, smart biohydrogels have been widely applied in osteochondral repair and regeneration, owing to their 3D structural resemblance to osteochondral tissues and their remarkable responsiveness to external stimuli. Glucosamine hydrochlo...

Aquest treball analitza les circumstàncies que van envoltar al pobler Guillermo Font, familiar de la Inquisició, protagonista d’un plet de competències entre el Tribunal de la Inquisició i la Real Audiència, sobre el seu enviament a presó l’any 1689 que han fet els ministres reals, per haver-li trobat a la seva casa amb pistola estant discutint amb...

Peptidoglycan (PGN) is a complex biopolymer crucial for cell wall integrity and function of all bacterial species. While the strong inflammatory properties of PGN and its derived muropeptides are well‐documented in human innate immune responses, adaptive immunity, including antibody responses to PGN, remain inadequately characterized. Microarray te...

La publicació recull els resultats del projecte I+D "La institucionalización de la modernidad. Artes en Mallorca (1874-1936)" (HAR2016-77135-P). La idea vertebradora del projecte era incidir en la transformació d’alguns aspectes artístics en un període carregat de matisos. Per una part, les arts esdevenen mitjans propagadors de les noves icones de...

Cancer, ranking just below cardiovascular diseases, is a leading cause of mortality worldwide. The key to enhancing survival rates among cancer patients lies in the early detection, removal, and treatment of tumors. However, the broad-spectrum nature of current treatments, including chemotherapy and radiation therapy, results in significant collate...

This study investigates the physicochemical properties of hydrogels based on PVA and PVP crosslinked with PEGDA, focusing on their swelling capacity, surface roughness, incubation behavior, and structural modifications upon bioactive component incorporation. Swelling analysis demonstrated that the amount and molecular weight of PEGDA significantly...

Upon recognizing bacterial lipopolysaccharide (LPS), human TLR4 initiates two distinct signaling pathways: the MyD88 pathway from the cell surface or the TRIF pathway following endocytosis. While the first is associated with strong pro-inflammatory responses, the latter is linked to dendritic cell maturation and T cell priming. Changes in LPS struc...

The descendants of Arariboia in the colonial society of Rio de Janeiro (16th-17th centuries) / Los descendientes de Arariboia en la sociedad colonial de Río de Janeiro (siglos XVI-XVII) RESUMO A partir de pesquisa documental e bibliográfica, bus-cou-se compreender o contexto em que viviam des-cendentes mulheres do líder indígena quinhentista Ararib...

Black soldier fly, H. illucens larvae, efficiently convert low-value organic substrates into high-value products, offering solutions to global challenges in sustainable food production and biotechnology. This study investigated the impact of dietary protein levels (10%, 14%, 16%, and 20% crude protein, CP) on BSFL growth, nutrient utilization, and...

This study examines how nitrogen and phosphorus fertilization influence soil microbial necromass carbon (MNC) content of farmland on the Loess Plateau, central Gansu. Based on an extensive (6 years) experiment, a control (CK, no fertilization) and three treatment groups employing different fertilization methods, namely, nitrogen fertilization (N, 1...

This essay argues that the inquisitorial process carried out against Sebastian del Castillo between 1672-1675 in Mexico City presents a set of evidence and implicit and explicit data of facts, relationships and social, political and economic processes, which exemplify how the action of a transgressive sexuality was a key mechanism of a systematic e...

Background Osteopenia is an asymptomatic condition till fragility fractures occur and may be linked to prolonged use of pantoprazole. Aim To determine osteopenic effect of long-term use of pantoprazole and study the possible protective role of glucosamine versus zoledronic acid on this effect in adult male albino rats. Patient and methods A total o...

Esta pesquisa teve como objetivo realizar um levantamento etnobotânico de plantas utilizadas para fins medicinais por uma comunidade rural do semiárido nordestino. O estudo ocorreu entre junho e outubro de 2024, no município de Euclides da Cunha-BA, por meio de visitas domiciliares com aplicação de um questionário semiestruturado. Contatou-se que a...

Physalis alkekengi L. fruit polysaccharides can reduce blood sugar, regulate blood lipids, and improve intestinal flora structure. However, the specific polysaccharide components exerting these effects are unclear. In this study, we extracted, separated, purified, and characterized the P. alkekengi polysaccharides Phy-1a, Phy-1b, and Phy-1c. Ion ch...

Uno de los avances más significativos de la medicina durante los últimos 60 años ha sido el trasplante de órganos, logrando mejorar la calidad de vida de personas con patologías crónicas o congénitas, que limitan su capacidad vital. Lo anterior es posible, a través del proceso mediante el cual se dona un órgano o un tejido de una persona a otra?, e...

Objectives: This study showcases the use of remote sensing technology for monitoring evolutionary patterns of mountain lakes under climate stress in the mid-hills and hard to reach glacial terrains, ranging about 650-8055 meters above the mean sea level in the Gandaki region of Nepal. Method: Spatiotemporal trends were analyzed from Landsat (Themat...

Social interactions are a fundamental aspect of human life, yet, their objective and naturalistic measurement remains challenging for scientific research. This challenge can be addressed using digital communication data. To this end, we have developed Dona, an open-source platform for donating messaging data from WhatsApp, Facebook, and Instagram....

Background and Objective: According to international guidelines, glucosamine and chondroitin, regarded as slow-acting drugs for osteoarthritis (SYSADOAs), have been first-line treatments for knee osteoarthritis (OA); however, their efficacies remain controversial. Additionally, the efficacies of plant extract cocktails, SKI306X, and its newer formu...

Osteoarthritis (OA) is a degenerative joint disorder that is characterized by progressive loss of cartilage, periarticular bone changes, and synovial membrane inflammation. Chondroprotectives such as chondroitin sulfate, glucosamine sulfate, hyaluronic acid, collagen hydrolysate, and other supplements play a significant role in OA treatment compare...

A Umbanda é uma religião híbrida que traz para si elementos de diferentes fontes e que é principalmente caracterizada pela sua paleta colorida de espíritos, dentre os quais se destacam exu e sua contraparte feminina: pombagira. A relação entre pombagira e a Umbanda passa necessariamente pela sua inequívoca associação ao feminino como algo perigoso,...

A pesquisa trata da educação de mulheres no Ceará na segunda metade do século XX, desenvolvida no primeiro colégio feminino da cidade de Fortaleza, capital desse estado. O objetivo foi compreender a instrução ofertada às moças de elite econômica cearense que estudavam no Colégio da Imaculada Conceição de Fortaleza (1865-1875). Teoricamente amparou-...

Objetivo: O objetivo deste trabalho é cartografar a experiência de uma pesquisadora na prestação de cuidados de enfermagem a duas usuárias idosas portadoras de lesões de difícil cicatrização que diferem muito entre si. Métodos: Esta pesquisa utilizou uma abordagem qualitativa como proposta metodológica, construindo suas análises por meio de uma car...

En este estudio se presenta la reconstrucción virtual del sistema defensivo del Castillo de Doña Blanca (CDB) a través de la aplicación de la arqueología virtual, lo que ha permitido avanzar significativamente en la comprensión de las técnicas poliorcéticas púnico-helenísticas en el sur de la península Ibérica. Este enfoque innovador ha sido clave...

Throughout history, various human civilizations have used raw materials obtained from the body parts, metabolic byproducts, or non-animal components of animals as medical resources for the treatment of numerous diseases and relief of symptoms. Protein structures, including hormones and enzymes, as well as various animal-derived metabolites includin...

Functional foods and nutraceuticals have gained attention as a result of the emergence of several human health disorders, including abdominal, obesity, diabetes, cardiovascular diseases, and neurodegeneration. The components of functional foods influence the physiological system, which enhances human health and fights against illness. The global co...

La Nova flora i atles corològic de Montserrat recull les plantes montserratines en un moment en què el medi natural està subjecte a una nova situació ambiental: la recuperació de la biomassa i la fitodiversitat vegetal després de l’incendi de 1986, la hiperfreqüentació humana: turisme, senderisme, vies ferrades, la depredació de la fauna salvatge (...

Els cicles pictòrics bizantins de les esglésies segueixen un simbolisme teològic estricte i ben planificat. No tothom pot ser pintor, ni un pintor pot pintar allò que li vingui de gust. Tot i això, l'ortodòxia es qüestiona amb figures paradigmàtiques com Maria d'Egipte: una santa dona representada a Bizanci com qualsevol altre sant anacoreta home....

L’article dona a conèixer una obra inèdita sortida en el mercat de l’art per ara tot desconeguda: un àlbum postromàntic realitzat i compilat entre el 1879 i el 1895, propietat de Ramon Romaní i Puigdengolas (1846-1898) destacat empresari català, innovador de la indústria paperera i líder de la industrialització a Catalunya de la segona meitat del s...

El propósito de este artículo es hacer una revisión en profundidad y en detalle de las principales características (conceptuales, técnicas, estéticas y artísticas) del proyecto pictórico site-specific Rompiendo Patrones, así como visibilizar y poner en valor todo el proceso de co-creación llevado a cabo por más de 35 personas durante los meses de a...

El portafolis digital, com a eina per a l’avaluació dels processos d’ensenyament-aprenentatge, està prenent cada cop més força en els diferents àmbits i etapes educatives i, entre aquests, a l’àrea de l’educació musical. Aquest article presenta, d’una banda, el procés de construcció d’una rúbrica per a l’avaluació del portafolis digital en la forma...

Les dues darreres dècades la mobilitat d’estudiants internacionals (MEI) ha experimentat un creixement significatiu, ja que s’ha passat de dos milions de persones matriculades en institucions d’educació superior (IES) estrangeres a 6,4 milions el 2021 (UIS-UNESCO, 2024). Aquest increment subratlla el paper central que la MEI té en les estratègies d...

Objectives Glucosamine (GlcN) is an important bioactive substance that is widely used in medicine, dietary supplements, cosmetics, and other fields. The traditional method of producing GlcN is mainly through chitosan hydrolysis catalyzed by strong acid, but this process is usually accompanied by environmental pollution and high energy consumption....

A Revista CPC foi fundada 2005 como parte das atividades do Centro de Preservação Cultural da Universidade de São Paulo, sediado na Casa de Dona Yayá. Organizado como Comissão Assessora da Reitoria, ganhou status de Centro no começo dos anos 2000, quando efetiva a proposta de mudança para a casa no bairro do Bixiga, região central de São Paulo. Com...

D. Joana da Casa de Avis (1452-1490) foi uma infanta portuguesa, filha de D. Afonso V, o Africano (1432-1481). Nunca tendo casado, as últimas décadas de sua vida foram vividas no Mosteiro de Jesus de Aveiro, local onde nunca professou os votos perpétuos, mas possuía influência política. Em 1585 foi publicado pelo frade dominicano Nicolau Dias (c. 1...

In our physical medicine clinic, we have a complex treatment for sports injuries that includes physical modalities, exercises and diet. The purpose of our presentation is to promote the program we use. Material and method: In the last 2 years, researching the available literature, we learned that physical fitness and shortening the rehabilitation t...

Günümüzün en acil çevresel sorunlarından biri, atıkların bertarafı, özellikle de düzenli depolama ile ilgilidir. Yanlış depolama yöntemleri nedeniyle yeraltı sularının kalitesi ciddi şekilde tehlikeye girmiştir. Vahşi depolama sahalarında insan sağlığı ve çevre kirliliğiyle ilgili problemler daha yaygındır. Bu düzensiz depolama sahaları birçok deza...

El presente artículo indaga sobre las propiedades inmuebles adquiridas por Micaela Villegas, “La Perricholi”, cantante y actriz de teatro limeña de la segunda mitad del siglo XVIII, cuya carrera continuó luego como empresaria teatral en los primeros años del siglo XIX. Famosa en la sociedad colonial limeña de su época por haber sido amante del virr...

Feminazis, ideòlogues de gènere, corruptores de la infància, progres… són conceptes que trobem a l’imaginari col·lectiu actual i que tracten de desprestigiar i menysprear els objectius que persegueix el feminisme. La facilitat amb què aquests i altres insults han estat incorporats en els discursos socials ens dona una pista de la necessitat urgent...

This paper reconstructs, through the intersection of documentary collections from Spanish and Portuguese archives of varied nature (ministerial, diplomatic, consular, military, police, etc.), the sequence of arrival and origin of the Spanish liberals during the constitutional regency of Doña Isabel María and their stay during the reign of D. Miguel...

Desde un abordaje de la familia como dispositivo privilegiado de formación y gobierno en la modernidad occidental, se examinan diferencias y regularidades en las prescripciones acerca de la formación de sujetos económicos en textos dirigidos a la familia en Europa y Colombia del siglo xv a la segunda década del xix. Estos textos hacen parte de tres...

Cap a finals d'aquest any pas-sat vam poder adquirir un conjunt de fotografies que s'oferien com a sis vistes de Bellpuig, cinc són al-búmines i la sisena és en base de paper-cartolina, normal de revelat. Les oferien com a fotografies del segle XIX i, per tres que porten se-gell en el positivament, sabem que, almenys aquelles són de l'any 1901. I t...

Doña Barbara no es solo una obra fundamental de la Venezuela del siglo XX, es quizá el documento cultural más importante de nuestra literatura. Gallegos recoge las tensiones de su tiempo, pero lo hace sin saber que su tiempo y el nuestro confluyen en los términos de nuestra identidad fragmentada y en un proceso de constitución de la nación que pare...

A análise de óbitos maternos do estado do Pará é essencial para compreender os impactos da COVID-19 nessa população e propor intervenções adequadas. Este estudo teve como objetivo investigar aspectos epidemiológicos, considerando dados sociodemográficos, e estimar os Anos Potenciais de Vida Perdidos (APVP) de mulheres que evoluíram à óbito por COVI...

This work presents the real story of Dona Diva, a semi-jewelry company operating in e-commerce and serving the entire national territory, both in wholesale and retail. This study focuses on highlighting the digital marketing strategies implemented by the company's founders and its marketing and sales team. Within this context, the primary objective...

Este trabalho apresenta a história real da Dona Diva, uma empresa do ramo de semijoias que opera no e-commerce e está presente em todo território nacional, tanto no atacado quanto no varejo. O foco é apresentar as estratégias de marketing digital utilizadas pelos sócios e pela equipe de marketing e vendas da empresa. Neste contexto, o principal obj...

Background Low-value care refers to the provision of health services that confer little or no benefit to patients, or have the potential to incur unwarranted harms. A breadth of literature exists investigating geographical variations in rates of potential low-value interventions for musculoskeletal pain. This scoping review aimed to examine the pro...

This article examines socio-environmental conflicts through the lens of political ecology, focusing on the disconnection within the society-nature dialectic and the dualistic, hierarchical understanding of urban-rural dynamics. The study is set in Bogotá, specifically in the Pasquillita village, a territory affected by the Doña Juana landfill and u...

este trabalho procura refletir sobre um conceito que é utilizado na sociologia e na antropologia de maneira irrefletida: o conceito de tradição. Que nunca é definido claramente, mesmo que possua usos políticos, como o de ser a negação da modernidade tanto no sentido de práticas quanto no de mentalidades. Nesta empreitada vamos primeiramente fazer u...

Chitosan, a biodegradable and biocompatible natural polymer composed of β-(1–4)-linked N-acetyl glucosamine (GlcNAc) and d-glucosamine (GlcN) and derived from crustacean shells, has been widely studied for various biomedical applications, including drug delivery, cartilage repair, wound healing, and tissue engineering, because of its unique physico...

Background With the approval of several anti‐amyloid antibodies and a robust pipeline of new amyloid‐based therapies, attention turns towards questions related to real‐world clinical practice. Here we explore the impact of several biological pathways on the amyloid biomarker response of AD patients using a Quantitative Systems Pharmacology (QSP) ap...

El Sermó de la Immaculada Concepció, de Felip de Malla, s’ha conservat en dos testimonis, un manuscrit de la Biblioteca de l’Abadia de Montserrat i un incunable de 1488, patrocinat per Ferrando Dies. El dit sermó conté un poema que, estructuralment, serveix com a nexe d’unió entre la introducció del sermó i el desenvolupament del tema. Entre una pa...

Although glucosamine (GlcN) exhibits antitumor effects, its mechanism of action remains controversial. Additionally, its impact on hepatocellular carcinoma (HCC) is not well understood. This study aimed to investigate the antitumor effects of GlcN and its underlying mechanism in a mouse HCC cell line, Hepa1-6. GlcN treatment significantly inhibited...

Esse trabalho objetiva redescobrir o escritor brasileiro esquecido Pedro de Castro do Canto e Melo (1866-1934) e estudar sua obra naturalista. Partimos do lugar reservado ao autor na historiografia literária como um “naturalista retardatário” que foi esquecido porque chegou tarde à cena literária. No intuito de desafiar essa explicação e compreende...

Sulforaphane (SFN) is an isothiocyanate derived from cruciferous vegetables that has demonstrated anti-cancer, anti-microbial and anti-oxidant properties. SFN ameliorates various disease models in rodents (e.g., cancer, diabetes, seizures) that are likewise mitigated by dietary restrictions leading us to test the hypothesis that this compound elici...

Cartilage deterioration in patients with osteoarthritis presents a significant challenge, primarily attributable to the inadequate oral bioavailability and poor dosage compliance of chondroprotective agents. The Chondroitin Sulphate (CS) is a stabilizing and reducing agent for metal NP as well as homing agent by binding to surface molecules (CD44,...

Background. Osteoarthritis (OA) is one of the most common joint diseases worldwide. The search for effective treatment regimens to reduce symptoms and improve joint function is essential. The purpose was to compare the effectiveness of different regimens of bioactive marine fish concentrate (BMFC) in the treatment of knee OA with oral glucosamine s...

Background: Mucopolysaccharidosis type IIID is caused by a deficiency of N-acetylglucosamine-6-sulfatase enzyme, which increases heparan sulfate accumulation in lysosomes and generate cytoplasmic vacuolation in central nervous system and somatic tissues. Goats kids with this disorder exhibit delayed motor development, growth retardation and sudden...

The article presented makes some considerations about the circulation of Jorge Amado's literature in Italy, with a late entry, compared to the translation of his novels in other countries in America and Europe. With this intention, the starting point is the report of the writer’s experience about his european exile, found in Navegação de Cabotagem,...

Los emprendimientos nacen como una alternativa a las necesidades que presentan sus fundadores que motivan la búsqueda y generación de nuevas actividades económicas a las ya existentes, y la teoría al respecto indica que a través de su desarrollo tienden a generar beneficios a nivel local en las comunidades que los albergan, por lo que estudios en e...

El presente artículo tiene como objetivo principal examinar detalladamente la construcción de la imagen de la reina María Cristina de Habsburgo Lorena, centrándose especialmente en los aspectos esenciales de su trayectoria vital: reina consorte, regente y reina madre. La hipótesis planteada se ajusta en la indagación sobre si los emblemas áulicos,...

Estudio de la Casa de los Manueles de Belmonte de Campos (Palencia) desde sus orígenes en el caballero literato don Juan Manuel. La rama principal continuó con don Fernando Manuel, II duque de Villena, y con la reina doña Juana Manuel, esposa del rey Enrique II de Trastámara. Con la extinción de dicha rama, la cabeza de linaje recayó en un hijo ile...

As comunidades remanescentes de quilombos sempre enfrentaram, mesmo antes da pandemia, uma série de dificuldades, como a falta de investimentos públicos e infraestrutura, o precário acesso a serviços de saúde, o preconceito, e a luta pelo direito à educação e à terra. Essas dificuldades se intensificaram ainda mais durante o período pandêmico. O fi...

Este artículo examina el impacto de un curso de pastelería inclusiva diseñado para personas con discapacidad, implementado en la Pontificia Universidad Católica del Ecuador – Ibarra, con el objetivo de evaluar cómo las estrategias pedagógicas adaptadas favorecieron el desarrollo de competencias técnicas y habilidades blandas. El curso, que tuvo lug...

In this investigation, collagen was successfully extracted from the skin and fins of the orange-spotted grouper, Epinephelus coioides, with recovery rates of 4.45% and 23.65% (dry weight basis), respectively. UV–Vis spectrophotometric analysis demonstrated distinct absorbance peaks at 222 nm and 217 nm for collagen isolated from the skin and fins,...

Este artigo discute aspectos da arte pública e as relações interculturais pensadas a partir do monumento público, um localizado na Philadelphia, em homenagem a o personagem do filme Rocky: um lutador (1976), e outro à Dona Dominga, situado em Vitória. Balboa e Dominga são imigrantes e pertencem a uma camada social excluída. Estabelecemos algumas co...

L’article ens parla del pallasso, o el clown. Explica per què és únic i particular i com és que cada persona ha de trobar el seu. El personatge és la persona i mostra les seves febleses, a diferència dels actors, que interpreten un personatge amb característiques particulars. S’hi dona informació per entendre-ho i conèixer el camí per arribar a aqu...

Doña María de Ulloa, condesa viuda de Salinas, sirve como camarera mayor de la reina doña Juana I de Castilla. Descendiente de la familia real castellana, la condesa pertenece a una nueva nobleza que asciende gracias a los servicios a la Corona y las conexiones familiares. Situaciones personales y políticas le otorgan posición relevante a principio...

Conrad’s last novel The Arrow of Gold (1919) not only dramatizes the intricate relationship between the protagonist, Monsieur George, and Doña Rita, but it also brings into focus the modern subject’s endeavour to exert control through the representation and objectification of women, ultimately perpetuating the oppressive discourse of patriarchy. Ge...