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A very interesting topic, "quantification of randomness" in mathematics it is sometimes reffered to as "complex theory" (although it is more about pseudorandom than randomness) that is based on saying that a complicated series is more random and then there are tests for randomness in Statistics and perhaps the most intriguing test related to information theory -"entropy"(as also being of relevence to and result of second law of thermodynamics), while there are also random numbers generators (pseudorandom numbers generators) and true random numbers generators using quantum computing.
So, what I've been trying to, is making a complete list of all available algorithms or books or even random number generators that will allow me to tell me how much random a series is, allowing me to "quantify randomness".
There are 125 unique infinite series which are pseudorandom that I have discovered and generated based on a rule, now how do I test for randomness and quantify it? Uf the series is random or there is probably a pattern, or something that will allow me to predict the next number in the series given I don't know what the next number is.
Now, do anyone know of any github links based on any of the above? ^ (like anything related to quantifying randomness in general that you think will be helpful).
A book/books on quantifying randomness will be very very helpful too. Actually anything at all...
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You should check out seminal and fundamental work by Gregory Chaitin starting in 1965 when he was a student in CUNY (City Univ. of New York) and continuing through the 1970's.
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Hi all,
Just wanted to know if there is a way to connect the AnyLogic Environment to GitHub and do git tasks.
Cheers
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I think GitHub codes are static, no?
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Hello. I want to ask if anyone knows methods for survivability in simulated GIT fluids and also aggregation (auto- and co-aggregation) using well plates (24 or 96 wells) for lactic acid bacteria? We want to use an absorbance microplate reader to hold the experiments.
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I have used the protocol in this paper in the past to determine auto and co-aggregation. It worked well. but was for a small study (not published).
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If we change bacteria in GIT will lead to behavioral change .
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Yes, it is possible. For example, researchers have addressed how the composition of the gut microbiome affects metabolism, energy absorption, and weight regulation. Gut colonization begins early in life and is greatly influenced by the mode of birth, feeding method, and antibiotic exposure. They found that colonization of an infant’s gut with optimal bacteria may help reduce the risk of obesity later in life.
Also, check the following RG link that may be useful:
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One of the common problems in data science is gathering data from various sources in a somehow cleaned (semi-structured) format and combining metrics from various sources for making a higher level analysis. Looking at the other people's effort, especially other questions on this site, it appears that many people in this field are doing somewhat repetitive work. For example analyzing tweets, facebook posts, Wikipedia articles etc. is a part of a lot of big data problems.
Some of these data sets are accessible using public APIs provided by the provider site, but usually, some valuable information or metrics are missing from these APIs and everyone has to do the same analyses again and again. For example, although clustering users may depend on different use cases and selection of features, but having a base clustering of Twitter/Facebook users can be useful in many Big Data applications, which is neither provided by the API nor available publicly in independent data sets.
Is there any index or publicly available data set hosting site containing valuable data sets that can be reused in solving other big data problems? I mean something like GitHub (or a group of sites/public datasets or at least a comprehensive listing) for the data science. If not, what are the reasons for not having such a platform for data science? The commercial value of data, need to frequently update data sets, ...? Can we not have an open-source model for sharing data sets devised for data scientists?
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Please generate a separate document to share this information on datasets.
It will be a great help to new researchers who spend a long time searching for such databases.
regards
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I have an issue. Lonafarnib is taken twice daily (morning, afternoon). If (in theory) we constructed orally administered nanoparticles and encapsulate the drug (to reduce GIT adverse effects) how could I also achieve to create a preparation that it would need to be taken only once daily? By using sustained release mode? And if so how? I am quite lost.
Thank you in advance
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At first you should specify which drug carrier you want to use or prepare...
If you are using known composition of previously used drug carrier,
then you should use additional compounds that can suppress the release to the half.
For example if the drug carrier is a swellable polymeric matrix, you can cross-link the matrix chemically or physically...
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SARS-CoV 2 is an enveloped virus. Enveloped viruses are known for their fragile nature and the inability to survive the passage through the gastrointestinal tract (damage by stomach acid). Several published reports confirmed the presence of both RNA and the viable Virus particles from stool and rectal swab samples.
My Question how this is possible???
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Hi! Sorry I haven't answered you. I saw this interesting question now. Do you have the answer?
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Hello,
I am actually working on probiotic lactic acid bacteria, can you help me, please to know the preferable percentage of viability of LAB after its passage through the GIT
for example, if my initial viability is 100 % what is the minimum needed after treatment with bile or acid?
Thank you
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LAB also has antioxidant effects and can stimulate endogenous antioxidants so it is good for boosting the immune system
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I'm trying to clone the respository for VCFtools into GitHub and configure it. These two scripts always run successfully in GitBash:
However, I cannot get the next two scripts to work:
./autogen.sh ./configure
Whenever I try the first script, I get the following error message:
matth@DESKTOP-FKTJ1JU MINGW64 ~/vcftools (master)
$ ./autogen.sh
./autogen.sh: line 3: autoreconf: command not found
All the files are in the GitHub folder on my computer (the GitHub folder is in Documents, in case that makes a difference). I need this program for my Masters thesis. Does anyone have any idea what's going on?
Please help if you can. Thanks in advance.
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Have look at conda installation : https://github.com/vcftools/vcftools/issues/96
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I think, ndoscopy is not essential for effective management of most of the UPPER GIT diseases.
Please share your view with research data
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I honestly believe that upper GI Endoscopy is essential for many upper GI diseases as a diagnostic as well as therapeutic tool. Diagnostic Biopsy, therapeutic hemostasis, Vareceal ligation are definitely added advantages. Steakhouse syndrome is corrected mostly by endoscopic manipulation.
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In vitro study for the digestion of compounds requires the same enzymes and chemicals as used in the Gastro-Intestinal Tract (GIT) model. so what would be the difference or similarities among them?
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Palak Mahajan To the best of my knowledge in vitro accessibility is not a commonly used term. Most likely the scientists have developed an assay including some kind of binding and came up with this description to make clear that they measured something else/new.
You should go back to the original publication to find out what they did and decide for yourself (together with a supervisor/colleague) what to do with this information.
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Porin channels are present in epithelium (GIT) and endothelium (blooe vessels) for permeation of hydrophilic substances. Then why highly hydrophilic drugs are given I/V instead of oral route?
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The attached article sheds more light on your question.
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When we do fluoroscopy from ileostomy, colostomy,I use insert catether in stoma, but without balooning it can reflux. so I doing balooning in stoma, anyone know how much balooning in diameter, we can do in ileostomy and colostomy?
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A foley catheter currently fits to ileostomy, and in colostomy too in many cases.
Anyway you can try an irrigation set, too
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Candida albicans is a dimorphic organism, a common commensal of oral cavity. It exists harmlessly in oral cavity, GIT, nose and many other sites of the body. In some situations it changes its nature and transforms into pathogens capable of causing infections. Why these transformations occur? Is it due to a change in micro-environment or due to a change in organism itself?
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Candida albicans is often harmless, kept in balance with other members of the local microbiota, However, many factors can change the status of C.albicans from harmless microorganism to serious pathogen, such factors are:-
-alteration in host-microbiota due to prolong uptake of antibiotics.
-Changes in host immune response during stress, infection by another pathogen, or immunosuppressant therapy.
-Variation in the local environment such as a shift in pH or nutrition content.
Best Regard
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Hello,
Inflammatory bowel diseases are chronic autoimmune diseases of GIT. Medical treatment and other therapies are used to reduce inflammation and suppress the overactive immune system.
So, Share your experience in management of pediatric inflammatory bowel disease and discuss the current treatment, life style goals and approaches.
Thanks for all
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Thank you Dr. Wesam for raising such an interesting topic for discussion. As im mainly concerned about Adult Rheumatology, ive seen less cases with IBD. In order to optimize the management it is always in comanagement with the Pediatrician and Gastroenterologist, provided the patient develops articular invovlement and becomes a seronegative spondyloarthritis (SpA) case. Furthermore, a good up to date reference is the Textbook of Pediatric Rheumatology:
Yet, for more detailed literature on IBD in children, the following article is informative:
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Machine learning has come a long way since early 1940's. Everyday I read so many papers about new improved models that has better accuracy/lower error rate compared to the one's that already exist. One of the major consumers of these models are industries. My question is going to have be of two parts
1. Have you programmed your ML model in one of the most popular languages such python & R and shared it in Git?
2. When you proposed a model or a new techniques or a workflow, have you ever considered a feature on implementing this in production environment? If so, how did you do it? <this is where most industries struggle today>
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Python is the only language I use for ML/AI works.
Regarding the deployment, I think the question should be more related with the 3V of the data. I have seen applications deployed on cloud with huge clusters, pipelines and high amount computing power to process data coming like a rain (talking about streaming for every milliseconds). Otherwise, I think for R&D and demonstration purposes, an interactive notebook hosted on cloud might be more than enough.
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aflatoxin B1 is low weight and diffused out metabolized from GIT tract. I think Aflatoxib B1 also can appear in milk.
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B1 convert to M1 after metabolization process in liver and transfer into milk.
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Fasting hyperglycemia and diabetes mellitus;
In clinical laboratory practice I had seen so many cases of type-II diabetes mellitus who gets a diagnosis of diabetes mellitus based upon raised fasting glucose but once u subject them with glucose load they easily manage there load. No doubt that fasting hyperglycemia is not not normal but i guess relying simply on fasting hyperglycemia, we may be overdoing the diagnosis part and in my personal opinion i feel w-hour postprandial glucose tolerance in an other wise healthy subject with any GIT pathology must be given to all subjects. Another thing which i have realized that once these subjects with fasting hyperglycemia reduce theri liver fat, they can overcome fasting hyperglycemia.
So fasting hyperglycemia and postprandial glucose tolerance are two varied concepts and the latter is a serious category. Then even thin, lean sometimes show poor glucose tolerance. And to me the latter category is worrisome rather than isolated fasting hyperglycemia.
So anybody wishes to comment on this? OR explain OR give some reasoning behind this?
Warm regards
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The aim is to get get a representative sample when sampling 3 times a day for 3 days. when is the right time to start faecal sampling?
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Ferreira et al. (2007), " Estimation of feed intake and apparent digestibility of equines and cattle grazing on heathland vegetation communities using the n-alkane markers''. is the only available literature.
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Do you know of any reference that indicates how to quantitatively measure the effort needed to merge two commits or branches?
A first intuition is that the effort depends on:
- the number of files to merge
- the number of conflicts
- the number of LOCs to merge
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It was a great pleasure for me! (Very interesting for me to think about this subject and to reflect my own experiences)
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Kindly share our experience with film array by BioMerieux for syndromic diagnosis using Meningitis/encephalitis, respiratory, GIT panel
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I didn't, it is so expensive.
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Hi,
There are many platforms that provide hosting services for software developers(e.g. Atlassian's Bitbucket, Github) for free, many open-source projects are hosted on these platforms and the data related to development process of these projects including commit histories, pull logs, number of contributors, etc are all available to the public; Some projects get extremely popular(for instance, a project has received many likes in Github), For example Docker(https://github.com/moby/moby; The original repository has been renamed to Moby), Now I'm asking, What are the features that popular open-source software project artifacts might have in common which makes it probable to predict that a particular project on Github, for instance, is going to be popular?
For instance:
- Does choosing a particular programming language helps?
- Do project need reach a minimum number of contributors? or a certain tipping point?
- Does a popular project always have a small dedicated team of core developers committing 24/7?
Do you know any previous research done on a similar problem?
Thanks,
Hassan
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A couple questions to get you started:
  1. how many unique fork and clone request are made to a git repo
  2. how many contributors
  3. how often those contributors make commits
Small commits can make a big impact, so size doesn't always matter.
Github provides contributor metrics. I'm not sure about fork/clone metrics.
Hope that helps. Cheers!
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i have silver nano particles after FTIR results i git the peaks and results are
The peak at 1620 cm-1 refers to carbonyl stretch, which is assigned to the amide I bond of protein. The peaks at 1373 refer to amino and amino-methyl stretching groups of protein. The peaks at 920 cm-1 refer to C-O stretching vibrations mode. The carbonyl groups of the amino acid residues and the peptides have strong ability to bind to the silver . It is also reported that the proteins can bind to nanoparticles either through free amine or cysteine groups in proteins
now i have question that i have used silver nitrate and fructose,, the i want the explanation of (amino-methyl stretching groups of protein)
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Dear Kamal Mustafa,
The peak at 1620 c.m-1 in your spectra corresponds to N-C=O amide I bond of protein. The peaks at 1373 refer to amino and amino-methyl stretching groups of protein. These two peaks confirm the presence of protein in reducing agent. This protein makes a stabilizing layer on AgNPs, which prevent the agglomeration of nano particles.
Here, you have been used silver nitrate as silver salt and fructose as reducing as well as capping agent. The clarification related to your query is deliberate afterwards the measurement of FTIR spectrum of fructose. The recorded FTIR spectra of fructose is compare with the FTIR of AgNPs.
You can also see the link below for better clarification:
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cefpodoxime is BCS IV class drug so I am trying to enhance its solubility. but I am not able to understand that from which part of GIT it is absorbed.
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Cefpodoxime proxetil is a slightly basic compound, absorbed from
the gastrointestinal tract after oral administration and hydrolyzed to its parent moiety cefpodoxime acid by nonspecific esterases in the intestinal wall. The reasons for low oral bioavailability of cefpodoxime proxetil are mainly attributed to low water solubility (400μg/ml), typical gelation behavior of cefpodoxime proxetil particularly in acidic environments, and pre-absorption luminal metabolism of its ester side chain by digestive enzymes cholinesterases present in the intestinal lumen into cefpodoxime acid.
References:
- Kakumanu VK, Arora V, Bansal AK. Investigation of factors
responsible for low oral bioavailability of cefpodoxime proxetil.
Int J Pharm. 2006;317:155–60.
- Kakumanu VK, Arora V, Bansal AK. Investigation of physicochemical
and biological differences of cefpodoxime proxetil
enantiomers. Eur J Pharm Biopharm. 2006;64:255–9.
- Manciet SC, Huneau JF, Decroix MO, Tomb D, Farinotti R,
Chaumeil JC. Cefpodoxime proxetil esterase activity in rabbit
small intestine: a role in the partial cefpodoxime absorption. Int J
Pharm. 1997;149:241–9.
- Schellens JHM, Malingre MM, Kruijtzer CMF, Bardelmeijer HA,
Tellingen OV, SchinkelHA, et al.Modulation of oral bioavailability
of anticancer drugs: from mouse to man. Eur J Pharm Sci.
2000;12:103–10.
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cefpodoxime is BCS IV class drug so I am trying to enhance its solubility. but I am not able to understand that from which part of GIT it is absorbed.
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You need to check whether cefpodoxime proxetil belongs to weak acidic or weak basic drugs. Generally, weak acidic and weak basic drugs are more soluble in basic and acidic medium, respectively.
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one example is Globulins present in Clostrum that absorbed as globulins without converting into polypeptide or amino acids.i want to know  more about such proteins.Thanks
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Phaseolin, Soybean Beta-conglycinin, most other protein allergens derived from peanut, soybean, mustard, egg and milk are resistant to proteolysis in the stomach.
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How will convert simulated GIT fluid PH from 1.2 to 7.8? For the Invitro dissolution study of Meloxicam loaded microparticles ?
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Dear Dr.Sayed
Kindly find the attachment for the preparation of simulated
biological fluids that may be used as dissolution media to evaluate different pharmaceutical dosage forms. You can alter/addition of reagents in the composition table.
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For example, My model looks like this:
Git=αGit-11Controlit2Focusit+ui+viit
Where, 
G - GDP per capita Growth rate
Git-1- lag of GDP per capita Growth rate
Another base regression model,
G=α+β1Initial GDP per capita+β2Controlit3 Focusit+ui+viit
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I don't have a short answer to this question, but to check out some of the technical issues involved (there are many), I would refer you to the a paper that I co-authored with Romain Wacziarg in 2009 in the Journal of Economic Growth, and a current working paper that I have entitled  "Endogeneity and Growth Regressions".  Both papers should be available through my Research Gate profile.  Good luck!
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I'd like to start an online lab notebook that is completely open and readable, shared with lab assistants and the world (explained on wikipedia: https://en.wikipedia.org/wiki/Open_notebook_science).  I'd also really like a whole online system for lab management- project organizing, sharing multiple notebooks and datasets.. Any suggestions?  I work in genetics and ecology but I think the system could be from any field.  Thanks!
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Thanks Luka!
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A git repository or any other codebase please.
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Check these two (the second one although not in C# could be used as a good reference):
as well as:
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I want to determine colon-specific delivery ability of nanoparticles designed in our study in comparison with Eudragit-s nanoparticles loaded with budesonide. I tried 100ug BUD which is recommended dose (0.4mg/kg), collect GIT segments after 8 hours and extract with methanol and analyse but not detected by HPLC, most probably BUD is degraded as reported in different studies. Can I use a high dose to make easy for analysis? Your suggestion will be appreciated.
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Thanks again. We are working on orally administered colon specific nanoparticles drug delivery, the alternative of BUD is C-6 to determine the ability of nanoparticles for colon-specific delivery.
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Like Github but with additional feature for hosting
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Many web hosting providers have a free tier or a free trial of their services so you can use their services for testing. Git repositories can be setup to automatically copy across your code to the web hosting provider through scripts associated with hooks.
If you do not wish to write your own scripts, you can use a service such as FortRabbit or PhpFog. Both providers have a free tier and support deployment through Git.