Science topic
Gastrointestinal Diseases - Science topic
Diseases in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.
Questions related to Gastrointestinal Diseases
In our traditional medicine some plants are used to cure Gastrointestinal disease. do some one know about some plants or phytochemical to cure IBD?
We need your expertise & opinion!
Please fill in this questionnaire:
A case of three males who presented strong precordial pain, in supine and prone position during night, with GERD and hiatal hernia type I ascertained by gastroscopy, treated by single manoeuvre, is described.
Methods
Manoeuvre consist in laying down patient in supine position, legs straight down and hands by his sides, using a pillow to lift up the head. Done that, subject should actively arches spine (at least 7-8 cm from the couch at level T12-L2), taking hyperlodosis position, without lifting sacral region, upper thoracic sections or any other segments from the couch.
Case Report
Three males complaining of stabbing precordial chest pain (mean ± standard deviation age, 24.6 ± 2.88 years; range, 20–28 years) have been treated between November 2016 and August 2017. Subjects have not suffered of any cardiac problem, normal EKG, pressure 80-120 mmhg, BMI 21.93 ± 2.49. While hiatal hernia type I and reflux disorders had been ascertained by gastroscopy in two of them, in the same year and three years before respectively.
Patients, stated to have suffered in the previous two weeks of strong precordial pain, in supine and prone position during night, not accompanied by burning retrosternal discomfort. Subjects also declared have not taken medication for GERD, or any other type of drugs and were symptomatic during the visit.
They were instructed to holding aforesaid position for 10 seconds at least, performing 3 time or more (with pause of 30 seconds between each prove), until symptoms vanish.
The manoeuvre was applied in each patients and complete precordial pain resolution was obtained in all attempts. Indeed, despite pain comes back after manoeuvre ends and patients laying down supine, three, four repetitions of aforesaid manoeuvre spaced with intervals of 30 seconds were able to lead a complete and sustained resolution of symptoms, all night long.
You may find out more, project and photo here https://www.researchgate.net/project/New-single-manoeuvre-leading-GERD-precordial-chest-pain-resolution-in-few-seconds-small-case-series
Do diaphragmatic breathing and speech therapy actually help? How often did you require multidisciplinary team approach?
Hello! Do you know any marketed and standardised or registered product derived from plants and used as anti-diarrhoeal or anti-infective in the gastrointestinal diseases in ruminants? Like for e.g. allicin, berberine, or may be purified fractions of some extracts, essential oils, oleoresins, etc., but it must be really standardised or registered in the EU, USA, Canada, Japan or somewhere and it must NOT be polyherbal formulation. Please help me if you know any such products. Thank you,
Dear fellow researchers,
Does anyone hold any useful information (or possibly a reasonable estimate) on the incidence rates (by age groups, if possible) of lactose intolerance and/or lactase deficiency in US?
Hi all,
I am wondering if you can comment on statistical interpretation of dysbiotic microbiome. For example, we treated a system with antimicrobials and now community is changed. Initial community is inhibited and new community took over the system. Now the question is, how can we say that this change is dysbiosis? Is there any statistical criteria established? Or its just qualitative interpretation? I assume that diversity and richness analysis may be used for this purpose but again what would be cutoff for such a purpose?
Thanks and looking forward to to your opinions...
Best,
Arslan
Good evening.
I´m searching for references related with the effect of Amprolium on the sporulating activity of Eimeria spp. oocysts.
Thank you.
There are some formula for estimating nares to lower esophageal sphincter distance in infants based on height. I'm looking for some data in adults to estimate such distance based on gender and height. What is important for me is the upper margin of the LES as we need to place a probe 5 cm above LES.
With this test could be possible obtain a complete precordial pain resolution (GERD related) in a few seconds. Manoeuvre is completely painless. However how does it work is partially uncleared, and it can be applied only in symptomatic subjects.
Manoeuvre has been conceived, and tested on subject, 23 years old, BMI: 19,48, pressure: 80-120 mmhg, normal EKG, without any cardiac problem and with hiatal hernia type I ascertained by gastroscopy. Presenting, strong precordial pain in supine and prone position during night, not accompanied by burning retrosternal discomfort. The subject does not take medication for GERD, or any other type of drugs.
It was performed 3 time every session (with pause of 30'' between each prove) and for 5 consecutive days on symptomatic subject.
Therefore, I'm looking for researches who have possibility to provide data, in order to verify this hypothesis.
We can work together on drug delivery systems to the gastrointestinal tract.
I am looking for clinical studies or drug trials related to children (age 0 to 6 preferably) that looked at children with varying GI issues, fistula, GERD symptoms, ulcers, etc that might have looked at child behavior. ADHD just seemed an easy search term, but it doesn't have to be limited to ADHD spectrum diagnoses.
Anismus (synonyms: spastic pelvic floor syndrome, sphincter dyssynergia, pelvic floor dyssynergia, dyssynergic defecation, paradoxal puborectal contraction) is a malfunction of the external anal sphincter and puborectalis muscle during defecation. It occurs in children and adults, sometimes from birth.
Specifically pertaining to colorectal and pancreatic cancer alongside other gastrointestinal malignancies, I was wondering what the experience has been in terms of data dictionaries, statistical support, size of databases and completeness of data.
Currently, I’m working with model of gastric ulcer induced by EtOH or NSAIDs (diclofenac). I use ImageJ software for macroscopic scoring to compare the ulcer area. Unfortunately, I couldn’t find any reliable system for microscopic scoring.
Could you recommend any scoring system to use in microphotographs (H&E staining) obtained from mice stomachs?
Samples are mouse plasma, from GI illness models (so mostly G neg bacteraemias expected); samples were collected in EDTA for other things, but want to check relative bacterial load if possible. ~200microl sample available. Absolute quantitation or speciation is not required, so something like endotoxin assays would be ok, but I understand most dont work on plasma.
Many thanks in advance!
As entitled, I seek for antibodies for IHC staining of mast cells in inflamed mouse colon. However, it cannot be antibody targeting chymases or tryptases.
Can someone recommend a perfect antigen of mast cells to be stained?
Hi everyone, I was wondering if I could please receive some feedback with something?
I am currently investigating what genes are being up regulated/down regulated in pigs suffering from a disease. We have collected bone tissue samples from healthy and diseased pigs across 3 age groups, extracted them for RNA, converted to cDNA and use qPCR to measure gene expression.
We are using the Pfafll method to calculate fold changes in our genes, and therefore require a calibrator on the 96-well plate. I was told by my supervisory team to pool my cDNA, from healthy and diseased pigs from all 3 age groups, and use this as the calibrator. Just to be clear; I made cDNA from bone RNA from all of my samples; and then cDNA was pooled and aliquoted to serve as a calibrator.
In my particular case, looking for changes in gene expression in diseased animals, would it make sense to have had only control samples pooled to form the calibrator and then calculate fold changes in diseased animals? My supervisor told me to pool everything, including diseased animals, so the calibrator effectively makes a standard curve and every individual sample can be calculated by referring back to this calibrator. However because the calibrator was a pooled sample from everything, does this mean that the expression values that I have obtained from my samples are not relative to anything? Therefore we would not know if the values for individual samples are relative to control or diseased? It would be great to hear your feedback on this, and whether this data can still be used.
Also, would this data still be valid if, for example, I average the normalized expression values from my controls; and then show the fold changes in expression for disease animals relative to the average of my controls?
I look forward to hearing your thoughts on this, many thanks in advance!
Could anyone can provide a list of parasitic and viral agents which cause gastro intestinal manifestations and list of inexpensive detection modalities available for the same.
I came across data from Osteopathy but missing evidence based data from Physical Therapy. All about Diagnosis/Red Flags, Prevention and treatment is welcome. Thank you!
I want to test the implications of a potentially pro inflammatory substance provided through diet, that affects the epithelium integrity, on developing chronic inflammation of the GI tract, I need a mouse model that develops inflammatory phenotype once the epithelium is disrupted. I'd like to know if anyone has experienced using this model? Are there any other mouse models that are more suitable?
Thank you
Isolated studies have proven superiority of this combination over plain aspirin in reducing gastric disturbances. The FDC of low dose aspirin and glycine is approved in India. However, data on its efficacy, safety and comparison with enteric coated aspirin is sparse.
45 yrs male with a BMI of 50,Diabetic for 8years presented with severe malena for 3days.On admission his Hb was 8gr/dl bl sugar was 200mgs,dyslipedimia other Biochemical parameters were normal XRay chest, ECG, Echcardio were normal. Upper Gi endoscopy was normal, scope could not be negotiated in to the 3rd part.U/S scan howed only Fatty Liver. CECT with angio was done revealed lipomatous filling defects in the above mentioned areas. Pt was resuscitated with Blood transfusions and control of Bl sugar.But slow oozing continued even though pt became stable.
Since 1838 physicians have described it in London, England . The term was attributed to Dr. Gill who coined the term in 1858. In physical diagnosis class in the 1950's in Manila, Philippines, we were advised that when an abdominal mass was felt, the differential diagnoses could include the Seven "F's": namely; Fat, Feces. Fetus, Flatus, Fluid, Fibroid. and "Phantom Tumor". So, what is a phantom tumor?
Do you have any experiences with faecal microbiota transplant in patients with megacolon due to C.difficile infection? We have already tried fidaxomycin (3 days), metronidazol, vancomycin for 2 weeks.
2 yr old with rectal biopsy confirmed Hirschsprung's dx. Had transanal Swenson's pull through. Intraop frozen section and Postop histopathology confirmed ganglion cells in pulled through margin. Patient had transient urinary retention that resolved in a few days. Started to have constipation after 2months of surgery. What are the management options available? Personal experiences will be appreciated.
Treating refractory IBD a-UC with anti TNF alpha AB seems not to be the right answer for most of the developing countries specially in Latin American populations, due to the high pharmacoeconomic impact that this therapeutic strategy implied. Therefore, more pragmatical approach is needed and there is growing evidence that microbiota and some helminths (i.e. T.suis and/or N. americanus) help with down regulating the IL-17/IL-22 relationship.
I'm curious about how the incidence of disease in the gut might affect protein uptake. Has anyone looked into this yet?
Dear Colleagues
As you are aware, typhilitis is a form of enterocoloitis or neutropenic colitis, a significant necrotising process that develops in the gastrointestinal tract of patients with neutropenia. It involves caecum and terminal ileum and often presents with fever, abdominal pain, diarrhoea, abdominal distension and rebound tenderness in the right lower quadrant. I would appreciate your valued comments on optimal management of this condition. Many thanks in anticipation for your contribution.
Sayed S Bukhari MD FRCPath
Consultant in Infection
Midlands, UK
I want to work on human cell lines(Gastro intestinal) to check for the activity against some group of bacteria??? please suggest me who can provide this service
Dear All,
I have a 60 year old male. He has had radical cystectomy, nephrectomy on the right and an urostoma constructed with an ileum conduit in his left lower abdomen. He was operated in 2/2014 due to a first recurrence of this parastomal hernia with a sublay-mesh. Then he developed a subcutaneous urinoma 2 days later and needed revisional surgery. the mesh needed to be removed, the hernia was closed with direct closure without a new mesh. After a few weeks he was developing a new parastomal hernia, as expected and presented in my outpatient clinic.
He need repair of his parastomal hernia, because its painful and disturbs in daily life.
The question is: which approach should we take? I think that direct approach from outside trying to fix the hernia with another mesh in sublay position will be difficult, because i'm expecting adhesions in the subfascial plane and large dissection will be needed. We decided for performing a transabdominal approach, with adhesiolysis and direct closure of the hernia including a IPOM mesh support (DynaMesh).
Any suggestions? Henry.
Adrenomedullin (AM) seems to be linked to pancreatic adenocarcinoma (ADC) and new-onset diabetes (NOD). Does anyone have any experience in this field? We are trying to test serum AM levels and immunohistochemical AM staining in patients with pancreatic ADC. We need to share our experience.
I'm wondering if there's a specific serum marker of activated T cells.
Can anybody help me with identification of the organisms in the liver and intestine of turtles? We suspect Entamoeba and/or Balantidium.
Few photos of the organisms in the sections, stained with HE and PAS are in the attached photos. The organs, staining and the maginification are listed in the file names.
Thank your very much for your help!
Tanja





+5
45 women suffering from irritable bowel syndrome which is refractory to conventional treatment
A 19 year old who was operated for Heirshprung's disease (Ileoanl anstamosis) 2years ago elsewhere presented with subacute small bowel obstruction. Abdomen is distended and small bowel loops are seen. It is not tender. Digital rectal examination is normal. CT scan showed distended small bowel loops up to the anus and Anus is collapsed.
Two studies up to now have shown an association between adenosine deaminase activity and disease activity in patients with Crohn’s disease and ulcerative colitis. We conducted a similar study in Crohn’s disease and in addition evaluated fecal calprotectin which is a known accurate disease activity marker for IBDs. But, we found no association between ADA activity and disease activity (evaluated by CDAI). Also no association was between ADA activity and FC, CRP, or ESR. But, ESR, CRP, and FC were all associated with disease activity.
What could be the reason for this difference between the study results?
Nowdays, endoscopists face the economic pressure to increase the number of colonoscopies by decreasing procedure time. Are there evidence based recommendations about the time limits of the withdrawal time? During this phase careful inspection occurs.
I work with inflammatory bowel disease and I want to analyse TGF-beta activity/levels
These samples are obtained from patients suffering from gastrointestinal disease.