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Functional Analysis - Science topic

Geometry of Banach space, Infinitely dimensional functional theory
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Publications related to Functional Analysis (10,000)
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Background Pancreatic cancer (PC) is a highly lethal disease and an increasing cause of cancer-associated mortality worldwide. Interferon regulatory factors (IRFs) play vital roles in immune response and tumor cellular biological processes. However, the specific functions of IRFs in PC and tumor immune response are far from systematically clarified...
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Apoptotic vesicles (apoVs) are specific extracellular vesicles generated during apoptosis and play important roles in multiple physiological and pathophysiological settings. Here, we present a protocol using differential centrifugation to separate apoVs from human mesenchymal stem cells (MSCs) after induction of apoptosis. We describe how to charac...
Article
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Background Adipose tissues (ATs), including visceral ATs (VATs) and subcutaneous ATs (SATs), are crucial for maintaining energy and metabolic homeostasis. SATs have been found to be closely related to obesity and obesity-induced metabolic disease. Some studies have shown a significant association between subcutaneous fat metabolism and sexes. Howev...
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In recent years, there has been renewed interest in line-start synchronous reluctance machines (LSSRMs) due to their simple construction, magnet-free rotor, and low cost. To improve control performance, design optimization, and fault diagnostic analysis of these machines, it requires accurate estimation of their electromagnetic characteristics usin...
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Turing inspired a computer metaphor of the mind and brain that has been handy and has spawned decades of empirical investigation, but he did much more and offered behavioral and cognitive sciences another metaphor—that of the cascade. The time has come to confront Turing’s cascading instability, which suggests a geometrical framework driven by powe...
Article
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Background: Existing BRCA2- specific variant pathogenicity prediction algorithms focus on the prediction of the functional impact of a subtype of variants alone. General variant effect predictors are applicable to all subtypes, but are trained on putative benign and pathogenic variants and do not account for gene-specific information, such as hotsp...
Article
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Background: Severe burns and blunt trauma can lead to multiple organ dysfunction syndrome, the leading cause of death in intensive care units. In addition to infection, the degree of immune inflammatory response also affects prognosis. However, the characteristics and clinical relevance of the common mechanisms of these major diseases are still und...
Article
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Northeast Asia has suffered from severe PM2.5 pollution and the exact mechanisms have yet to be fully understood. Here, we investigated the transformation processes of submicron aerosols using a 4-year data set obtained at Jeju, a Northeast Asian background site. The diurnal-cycle constrained empirical orthogonal function analysis of nanoparticle s...
Article
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Background The Symptom Checklist (SCL) developed by the Health Behaviour in School-aged Children (HBSC) study is a non-clinical measure of psychosomatic complaints (e.g., headache and feeling low) that has been used in numerous studies. Several studies have investigated the psychometric characteristics of this scale; however, some psychometric prop...
Article
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Fully shaped, morphologically standardized bone tools are generally considered reliable indicators of the emergence of modern behavior. We report the discovery of 23 double-beveled bone tools from ~ 80,000-60,000-year-old archaeological layers at Sibudu Cave in KwaZulu-Natal, South Africa. We analyzed the texture of use-wear on the archaeological b...
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The protein Talin1 encoded by the TLN1 gene is a focal adhesion-related protein that binds to various cytoskeletal proteins and plays an important role in cell adhesion and movement. Recent studies have shown that it is overexpressed in prostate cancer, liver cancer, and oral squamous cell carcinoma, and is closely related to tumor progression and...
Article
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A new co-infection model for the transmission dynamics of two virus hepatitis B (HBV) and coro-navirus (COVID-19) is formulated to study the effect of white noise intensities. First, we present the model equilibria and basic reproduction number. The local stability of the equilibria points is proved. Moreover, the proposed stochastic model has been...
Article
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IntroductionAlthough there is accumulating evidence that genetic factors play a vital role in the pathogenesis of epilepsy, few epilepsy-associated genes have been identified. Additionally, the role of KCNJ15 in epilepsy has not been evaluated so far.Methods Here, we performed differentially expressed gene analysis, expression quantitative trait lo...
Article
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Background The WT-boxes NGACTTTN are novel microbe-associated molecular pattern (MAMP)-responsive cis-regulatory sequences. Many of them are uncommon WRKY transcription factor (TF) binding sites. Results To understand their functional relevance, a genomic distribution analysis of the 16 possible WT-boxes and a functional analysis of a WT-box rich...
Article
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Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), has infected millions of individuals worldwide. While COVID-19 generally affects the lungs, it also damages other organs, including those of the cardiovascular system. Hypertrophic cardiomyopathy (HCM) is a common gene...
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The importance of T cells in controlling SARS-CoV-2 infections has been demonstrated widely, but insights into the quality of these responses are still limited due to technical challenges. Indeed, understanding the functionality of the T-cell receptor (TCR) repertoire of a polyclonal antigen-specific population still requires the tedious work of T-...
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Precipitation and sea surface temperature (SST) are important variables, the coupling of which is crucial in understanding the variation in the Earth’s climate under the effects of global warming. We evaluated the precipitation–SST (P–SST) and precipitation–SST tendency (P–SST′) correlation by comparing the updated Coupled Model Intercomparison Pro...
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Physical activity is deemed critical to successful ageing. Despite evidence and progress, there is still a need to determine more precisely the direction, magnitude, intensity, and volume of physical activity that should be performed on a daily basis to effectively promote the health of individuals. This study aimed to assess the clinical validity...
Article
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Lily-type lectin (LTL) plays significant roles in innate immune response against pathogen infection. LTL in animals and plants has received widespread attention. In the present study, an LTL (OppLTL) was identified from spotted knifejaw Oplegnathus punctatus . The OppLTL encoded a typical Ca ²⁺ -dependent carbohydrate-binding protein containing a C...
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Background The relationships between inflammatory indexes and atherosclerosis as well as those between blood lipid indexes and atherosclerosis have been widely studied, but the relationship between the neutrophil to high-density lipoprotein cholesterol ratio (NHR) and atherosclerosis had not been investigated until the present study. Methods For t...
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Leucoanthocyanidin reductase (LAR) is the critical enzyme in the synthesis pathway of proanthocyanidins, which are the primary pigments in brown cotton fibers. Our previous study has revealed significant differences in the expression levels of GhLAR1 between white and brown cotton fibers at 10 DPA. In this work, the expression pattern of the GhLAR1...
Article
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Nearly 2000 SNPs associated with pig litter size traits have been reported based on genome-wide association studies (GWASs). The aims of this study were to gather and integrate previously reported associations between SNPs and five litter traits: total number born (TNB), number born alive (NBA), number of stillborn (SB), litter birth weight (LWT),...
Article
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Background and objectives. Sepsis is a life-threatening organ dysfunction caused by the imbalance of the body’s response to infection. Delay in sepsis diagnosis has become a primary cause of patient death. This study aims to identify potential biomarkers of sepsis based on bioinformatics data analysis, so as to provide new gene biomarkers for the d...
Article
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The article is devoted to the analysis of abbreviations used in online news media. The relevance of the study is because the structural, thematic, and functional characteristics of abbreviations are considered in direct connection with the features of online media. The material for the study was 500 abbreviations obtained by continuous sampling fro...
Chapter
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Although many papers have been published in the past on the use of TRIZ in the field of Information Technology, questions still arise as to whether the TRIZ methodology is also suitable for software as purely intangible systems.Doubts remain because the methodology was developed at a time when patents for IT and software systems, in contrast to phy...
Chapter
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Today’s world extensively uses Information Technology (IT) and heavily depends on IT systems. The evident and justified need to model IT systems in TRIZ projects faces some doubts or objections because the fundamental concepts of classic TRIZ were formulated before computer times. This paper aims to analyze terminology and guidelines regarding Func...
Article
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N-methylpretrichodermamide B (NB) is a biologically active epidithiodiketopiperazine isolated from several strains of the algae-derived fungus Penicillium sp. Recently, we reported the first data on its activity in human cancer cells lines in vitro. Here, we investigated the activity, selectivity, and mechanism of action of NB in human prostate can...
Article
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An empirical orthogonal function (EOF) analysis was performed for the inner core of Typhoon Hagibis (2019) in the intensification phase. The Himawari–8 geostationary infrared (IR) brightness temperature (BT) collocated at the Hagibis’s center was combined with the IR BT simulated by a radiative transfer model, with 1 km ensemble simulations conduct...
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The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin resistance. It is also associated with an increased cardiovascular disease risk, including hypertension and atherosclerosis. Hepatic lipid metabolism is regul...
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Recently, Artificial intelligence (AI) has emerged as a revolutionary field, providing a great opportunity in shaping modern crop breeding, and is extensively used indoors for plant science. Advances in crop phenomics, enviromics, together with the other "omics" approaches are paving ways for elucidating the detailed complex biological mechanisms t...
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Lithium battery slurry wastewater was successfully treated by using basalt fiber (BF) bio-carriers in the biological contact oxidation reactor. This resulted in a significant reduction of COD (93.3 ± 0.5%) and total nitrogen (77.4 ± 1.0%) at 12 h of HRT and dissolved oxygen (DO) of 0-1 mg/L. The modified Stover-Kincannon model indicated that the to...
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Magnetic resonance urography (MRU) is an important MRI application that provides noninvasive comprehensive morphological and functional evaluation of the kidneys and urinary tract. It can be used to assess congenital anomalies of the kidney and urinary tract, which often present as urinary tract dilation. In children, MRU allows for high tissue con...
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G protein-coupled receptors (GPCRs) modulate every aspect of physiological functions mainly through activating heterotrimeric G proteins. A majority of GPCRs promiscuously couple to multiple G protein subtypes. Here we validate that in addition to the well-known Gi/o pathway, somatostatin receptor 2 and 5 (SSTR2 and SSTR5) couple to the Gq/11 pathw...
Conference Paper
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With the aim to meet the heightening food demand of the ever-increasing population, several irrigation schemes were established particularly in arid and semi-arid regions of the world. In Nigeria, huge investment has been made to develop irrigation infrastructures. However, many reported instances revealed that a larger proportion of these irrigati...
Article
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Influenza viruses deliver their genome into the nucleus of infected cells for replication. This process is mediated by the viral nucleoprotein (NP), which contains two nuclear localization sequences (NLSs): NLS1 at the N-terminus and a recently identified NLS2 (212GRKTR216). Through mutagenesis and functional studies, we demonstrated that NP must h...
Article
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Background Existing data suggest that cerebral autoregulation (CA) varies among different subtypes of ischaemic stroke. CA is globally impaired in patients with small artery occlusion (SAO). However, the factors influencing CA impairment in patients remains to be elucidated. Methods Stroke patients with SAO who underwent brain magnetic resonance i...
Preprint
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MicroRNAs (miRNAs) have emerged as important factors during intervertebral disc degeneration. The cartilage endplate (CEP) is an important site for solute exchange and the import of nutrients for intervertebral disc degeneration. This study was to determine whether miR-210-5p regulates interleukin-1β (IL-1β)-induced expression of YAP1 (Yes-associat...
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Metagenomic analysis of stone microbiome from samples collected in New England, USA and Tamil Nadu, India identified numerous Actinobacteria including Geodermatphilaceae. A culture-dependent approach was performed as a companion study with this culture-independent metagenomic analysis of these stone samples and resulted in the isolation of eleven G...
Article
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This paper presents the results obtained from experimental modal analysis and static load testing to examine the suitability of the dynamic parameters to estimate stiffness deterioration severity in RC structures. The study investigates the accuracy of different dynamic-based stiffness indices compared to static-based flexural and shear stiffness i...
Article
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Background: Although metabolomic analysis for patients with non-alcoholic fatty liver disease (NAFLD) was a promising approach to identify novel biomarkers as targets for the diagnosis of NAFLD, the serum metabolomics profile of early-stage NAFLD patients from central China remain unknown. Objective: The aim of this study was to explore the meta...
Conference Paper
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Long-term human exploration missions to the lunar surface require food supply and reliable life support systems. One element for such an undertaking is a greenhouse system, which is able to produce fresh food for the crew and at the same time provide a bio-regenerative life-support system. DLR has been working on this concept for several years and...
Preprint
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Crosstalk between cancer and stellate cells is pivotal in pancreatic cancer, resulting in differentiation of stellate cells into myofibroblasts that drive. To assess co-operative mechanisms in a 3D context, we generated chimeric spheroids using human and mouse cancer and stellate cells. Species-specific deconvolution of bulk-RNA sequencing data rev...
Preprint
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Methods that are resilient to artifacts in the cardiac magnetic resonance imaging (MRI) while performing ventricle segmentation, are crucial for ensuring quality in structural and functional analysis of those tissues. While there has been significant efforts on improving the quality of the algorithms, few works have tackled the harm that the artifa...
Article
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Water pollution is the presence or introduction to the contamination of water boundaries, including oceans, rivers, lakes, aquifers, and groundwater. This condition usually occurs as a result of human activities. Water pollution occurred when contaminants introduced into the natural environment, and this may become a threat to marine or aquatic lif...
Preprint
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The geminivirus beet curly top Iran virus (BCTIV) is one of the main causal agents of the beet curly top disease in Iran and the newly established Becurtovirus genus type species. Although the biological features of known becurtoviruses are similar to those of curtoviruses, they only share a limited sequence identity, and no information is availabl...
Article
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In this paper, we mainly present the dynamic properties of a stochastic SICA model with general incidence rate. Through rigorous analysis and reasoning of the stochastic model, we obtain that the solution of the model is global, positive, and unique. By constructing the threshold value R0s$$ {R}_0^s $$, which includes the influence of white noise,...
Article
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UDP-glycosyltransferase (UGT) plays an essential role in regulating the synthesis of hormones and secondary metabolites in plants. In this study, 129 members of the Petunia UGT family were identified and classified into 16 groups (A–P) based on phylogenetic analysis. The same subgroups have conserved motif compositions and intron/exon arrangement....
Article
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Background Clinical classification of autistic patients based on current WHO criteria provides a valuable but simplified depiction of the true nature of the disorder. Our goal is to determine the biology of the disorder and the ASD-associated genes that lead to differences in the severity and variability of clinical features, which can enhance the...
Article
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The nonparametric estimation of density and regression function based on functional stationary processes using wavelet bases for Hilbert spaces of functions is investigated in this paper. The mean integrated square error over adapted decomposition spaces is given. To obtain the asymptotic properties of wavelet density and regression estimators, th...
Article
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Medieval greyware pottery from l'Esquerda (Roda de Ter, Osona): morphometric approach, functional analysis and provenance Les excavacions arqueològiques a l'Esquer-da es van iniciar el 1977 i encara continuen a dia d'avui. Durant més de quaranta anys els treballs en aquest jaciment han permès recu-perar una quantitat ingent de ceràmica grisa que,...
Article
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Because spatio‐temporal variations in ocean heat content (OHC) are strongly predicted by ocean conductivity content (OCC) over most of the global ocean, we analyze the dynamical budget and behavior of the electrical conductivity of seawater. To perform these analyses, we use an ocean‐model state estimate designed to accurately represent long‐term v...
Article
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Coinfection of Ebola virus and malaria is widespread, particularly in impoverished areas where malaria is already ubiquitous. Epidemics of Ebola virus disease arise on a sporadic basis in African nations with a high malaria burden. An observational study discovered that patients in Sierra Leone’s Ebola treatment centers were routinely infected with...
Preprint
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Based on our previous animal model of abnormal metabolism, we combined bioinformatics methods to explore the mechanism of early embryo oxidative stress increasing metabolic risk in offspring. Methods: To screen the differentially expressed genes (DEGs) between IVF and naturally conceived offspring by bioinformatics methods, and to identify the co-g...