Focused Ultrasound - Science method

please drop images of the signals

Related to your query, I suggest you first start literature review, e.g., https://www.nature.com/articles/s41598-018-28320-1

We inject PC-3 cells into the hind flank of mice when doing xenografts (http://altogenlabs.com/xenograft-models/prostate-cancer-xenograft/pc-3-xenograft-model/). Based on your experimental conditions I think you could also do such an injection and proceed with the radiation protocol as you've stated it. If you're trying to not damage vital organs then the hind flank is one of the more "distant" locations from such organs.

Hello,

here some other hints in this regard:

Best

F.

I am not a specialist in neurology but  I think that neuronal current is alternative current of some frequency (it is seen in EEG). The frequency is small and it gives a rise to J(0) (spectral density of magnetic field fluctuations at zero frequency). We know that only T2 (spin-spin relaxation time) is sensitive to this spectral density. So I have a question. Why do we not see neuronal currents at high field MRI. What "dwarfs" means? Could we use the method of T1 in rotation coordinate system ? Low field MRI is very unsensitive.

Yes.  Decidedly yes. There are many patients with diseases whose conditions are not amenable to implanted electrodes for whom an ablative procedure can be very helpful.  There are, for example, elderly patients whose underlying cardiovascular disease mandates anticoagulant therapy that cannot be discontinued who may be candidates for radiosurgical treatment of a movement disorder, and patients with gelastic seizures from hypothalamic hamartomas that cannot be safely resected for whom an ablative or neuromodulatory radiosurgical procedure can improve seizure control.  Obsessive compulsive disorder and medial temporal lobe epilepsy have been successfully treated with Gamma Knife radiosurgery and musicians' dystonia is yet another condition that has been shown to be successfully treated by ablative neurosurgical procedures. 

Dear Julien Lambert,

Look these papers:

Good luck

I want talk about HIFU monitoring with MR and ultrasound. Compared with MR, ultrasound has better temporal resolution and lower cost. However, currently MR thermometry is the only clinically-feasible temperature imaging method. Ultrasound temperature imaging techniques are under heavy investigation, but still far from being clinically applicable. This is mainly due to the low temperature estimation accuracy and limited applicable temperature range (most of them are applicable in 37-45 degrees Celsius). Another aspect of ultrasound-based HIFU monitoring is related to thermal lesions (or ablation zones) when tissue coagulation necrosis forms. This aspect is under extensive exploration too.

There are several centers world wide using CEUS in a trauma setting. In the US Boston Childrens has a study on going. Several other adult centers scattered across the US are using it mostly on a research basis but the number is growing. There is no reimbursement at this time for a hospital setting using CEUS.

interquartile range (IQR), is a measure of statistical dispersion, being equal to the difference between the upper and lower quartiles.

M - median

Laser vibrometry,e.g. By Polytec, specle interferometry, e.g. by BossaNova, dynamic white light interferometry, e.g by Wyco Bruker or other classical Michaelson interferometers. They are just a tad more tricky to use.

It depends a bit on the anplitudes and frequencies you want to detect and if you look at single spots or entire arrays of transducers all at once. I have even used an AFM to measure Piezo trancducer displacement,but at near DC frequencies, i.e. step responces.

Marko