Science topic
Fibromyalgia - Science topic
A common nonarticular rheumatic syndrome characterized by myalgia and multiple points of focal muscle tenderness to palpation (trigger points). Muscle pain is typically aggravated by inactivity or exposure to cold. This condition is often associated with general symptoms, such as sleep disturbances, fatigue, stiffness, HEADACHES, and occasionally DEPRESSION. There is significant overlap between fibromyalgia and the chronic fatigue syndrome (FATIGUE SYNDROME, CHRONIC). Fibromyalgia may arise as a primary or secondary disease process. It is most frequent in females aged 20 to 50 years. (From Adams et al., Principles of Neurology, 6th ed, p1494-95)
Publications related to Fibromyalgia (10,000)
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Juvenile fibromyalgia (JFM) is a chronic widespread pain condition that primarily affects adolescent girls. Previous studies have found increased sensitivity to noxious pressure in adolescents with JFM. However, the underlying changes in brain systems remain unclear. The aim of this study was to characterize pain-evoked brain responses and identify...
Aiming to identify the potential challenges in the classification of musculoskeletal manifestations in patients with psoriasis (PsO), this study analyzed the outcomes of a cross-sectional rheumatologic assessment of 1057 PsO patients. In total, 209 had a previous diagnosis of psoriatic arthritis (PsA). Out of the remaining 848 subjects, 293 (35%) w...
We show FMS patients with high pain produce autoantibodies that stain SGCs more than pain-free controls. We confirm the Swedish and Canadian data, therefore, strengthening the hypothesis that SGC autoimmunity may contribute to FMS pain, and indicating a role for therapies reducing serum-autoantibodies.
Vibrational heating therapy is a type of physical therapy that uses the application of heat and vibrations to stimulate the body’s healing process. The therapy is believed to promote circulation, reduce inflammation, and relieve muscle tension. It is often used to treat conditions such as arthritis, fibromyalgia, and sports injuries. This paper pre...
Introdução. O diagnóstico da fibromialgia vem sendo frequentemente atualizado incluindo sinais característicos do binômio depressão/ansiedade. Objetivo. Estabelecer as características de estados de depressão/ansiedade em um modelo animal de fibromialgia induzido por injeções repetidas de reserpina em ratos Wistar sob o efeito do tratamento com extr...
Objective. The pathophysiology of fibromyalgia (FM), a continuously painful syndrome with no known origin,
has been related to mitochondrial dysfunction, oxidative stress, and inflammation. Recent studies have shown that
FM may be associated with an oxidative balance disorder. The objective of this study was to measure the levels of
oxidative stres...
Objective. Dietary interventions to improve fibromyalgia (FM) symptoms reported conflicting results. This study aimed to treat FM patients with a gluten-free diet (GFD), alternated with a non-restricted gluten-containing diet, followed by a rechallenge of the GFD. Methods. Twenty postmenopausal women with FM and no history of celiac disease partici...
Fibromyalgia is a chronic condition of unknown etiology unrelated to specific laboratory markers for diagnosis because of poor etiopathogenesis. In general, the changes common to fibromyalgia are also seen in other chronic pain conditions, making the pathogenesis controversial among different pathological conditions. The unknown etiology makes the...
Ehlers–Danlos Syndrome (EDS) is a rare disease affecting the skin, joints, vasculature, and internal organs. Approximately 85% of those affected are categorized as the hypermobile type (hEDS), which is associated with numerous medical and psychiatric comorbidities, including chronic pain. Additionally, approximately 71% of patients with hEDS underg...
RESUMEN La artritis psoriásica (APs) es una enfermedad autoinmune sistémica asociada a la psoriasis, conocida ahora dentro de un único espectro llamado enfermedad psoriásica, y otras comorbilidades como lo son enfermedad cardiovascular, síndrome metabólico, inflamación intestinal subclínica, trastornos del estado de ánimo, mayor riesgo de infeccion...
ObjetivoAvaliar a prevalência de enxaqueca em pacientes com fibromialgia e os impactos dessas comorbidades no cotidiano dos pacientes.MétodosQuestionários foram aplicados a pacientes com fibromialgia. Os questionários foram aplicados por meio de link de aplicativo Google Forms e presencialmente, impressos. Usamos FIQ, PHQ-9 e enxaqueca ID. E para p...
Background
Fibromyalgia is a syndrome characterized by chronic widespread pain accompanied by fatigue, disrupted sleep quality, cognitive impairments, subjective soft tissue swelling, and somatic symptoms. There are conflicting results in the literature regarding the prevalence of vitamin D deficiency in fibromyalgia patients and the reduction of s...
A fibromialgia é uma síndrome dolorosa e crônica manifestada no sistema musculoesquelético. As Práticas Integrativas e Complementares em Saúde (PICS) oferecem atenção humanizada e atendimento multiprofissional, como a meditação, que pode ser eficaz no tratamento complementar de pacientes com fibromialgia. O objetivo do estudo foi conhecer os efeito...
Madam, In Pakistan, cases of stress-related illnesses are on a steady incline. Fibromyalgia is a rapidly growing example of an illness characterized by widespread chronic pain, especially on specific tender points.1 This can be caused by stress, depression, anxiety, or traumatic events present in one's daily life. However, the exact cause is unknow...
Introducción. La fibromialgia es una enfermedad reumática crónica cuya principal característica es un dolor agudo y persistente en la mayor parte del cuerpo. Se ha demostrado que los síntomas de depresión en pacientes con fibromialgia puede empeorar el curso de la enfermedad y acentuar el dolor. El objetivo del presente estudio fue comparar el efec...
Introduction
There has been increased interest in addressing chronic pelvic pain and its complexity in women. The often multifactorial etiology of chronic pelvic pain and its heterogeneous presentation, however, make the condition challenging to manage. Overlap with other pain‐related conditions is frequently reported, and chronic pelvic pain may i...
Fibromyalgia syndrome (FMS) is a nonarticular rheumatic syndrome which presents as chronic musculoskeletal pain, stiffness and body aches. FMS affects approximately 2.5% of the population, mostly women. FMS causes physical and psychological problems and reduces quality of life. The objective of this study is to identify qualitative evidence about e...
Objective:The aim of this study was to determine the extent to which body image is affected by pain severity in patients diagnosed with fibromyalgia (FM).Method:A total of 51 patients who were selected from the psychiatry and algology outpatient clinics and had their informed consent obtained were included in the study. All patients were evaluated...
Fibromyalgia is a soft tissue rheumatism with significant qualitative and quantitative impact on sleep macro and micro architecture. The primary objective of this study is to analyze and identify automatically healthy individuals and those with fibromyalgia using sleep electroencephalography (EEG) signals. The study focused on the automatic detecti...
Introduction
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked enzymatic disorder that is particularly prevalent in Africa, Asia, and the Middle East. This study aimed to assess the long-term health risks associated with G6PD deficiency.
Methods
A retrospective cohort study was conducted using data from a national healthcare provi...
Objectives: Fibromyalgia syndrome (FMS) is a stress-related disease. The birth of a child with cerebral palsy (CP) is an important stress factor for the mother. This study aims to investigate the incidence of FMS in mothers of children with CP by comparing it with the control group and determining the factors affecting the severity of FMS. Methods:...
Although it is widely known that joint involvement is the most frequent and prevalent manifestation of systemic lupus erythematosus (SLE), not having a validated organ-specific index for this domain in order to guide its treatment has been a major limitation. In addition, its clinical importance had been underestimated since it was not a vital risk...
Objective. Chronic musculoskeletal pain (CMP) poses a considerable threat to physical, mental, and financial health worldwide. Beyond physical difficulties, CMP has a pronounced impact on pain behaviors and cognitive function. The purpose of this scoping review was to examine the relationship between pain catastrophizing (PC) and cognitive function...
Anger, is known as wrath or rage, is an intense emotional state involving a strong uncomfortable and non-cooperative response to a perceived provocation, hurt or threat. Anger is an emotional reaction to threat, frustration, or social provocation.
In this research, the Biblical verses dealing with anger are described. Therefore, the research prese...
Background
There is growing evidence of the significance of gastrointestinal complaints in the impairment of the intestinal mucosal barrier function and inflammation in fibromyalgia (FM) and in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). However, data on intestinal permeability and gut barrier dysfunction in FM and ME/CFS are still...
Physical exercise is an indispensable element in the multidisciplinary treatment of fibromyalgia syndrome (FMS). The present study examined if men diagnosed with FMS engaged in any type of physical activity or exercise, the perceived effects from exercise, and who specifically recommended exercise. A qualitative cross-cultural study was performed i...
RESUMO: A fibromialgia é a terceira condição musculoesquelética mais frequente, e sua prevalência aumenta com a idade. É caracterizada por dor crônica generalizada, fadiga, distúrbios do sono e sintomas funcionais. Seus critérios diagnósticos e classificatórios ainda estão em discussão e, consequentemente, as estratégias para seu o tratamento. Dest...
Abstract Background Fibromyalgia (FM) is a multifaceted disease. Along with the genetic, environmental and neuro-hormonal factors, inflammation has been assumed to have role in the pathogenesis of FM. The aim of the present study was to explore the differences in clinical features and pathophysiology of FM patients under different inflammatory stat...
Objective:
Hypophosphatasia (HPP) is a rare disease characterized by incomplete or defective bone mineralization due to a mutation in the alkaline phosphatase (ALP) gene causing low levels of ALP. Disease presentation is heterogeneous and can present as a chronic pain syndrome like fibromyalgia (FM). Our objective was to determine if there are any...
Recent translational work has shown that fibromyalgia (FM) might be an autoimmune condition with pathogenic mechanisms mediated by a peripheral, pain-inducing action of IgG antibodies binding to satellite glia cells (SGC) in the dorsal root ganglia (DRG). A first clinical assessment of the postulated autoimmunity showed that fibromyalgia subjects (...
Background
Headache disorders are widely prevalent and pose a considerable economic burden on individuals and society. Globally, misdiagnosis and inadequate treatment of primary headache disorders remain significant challenges, impeding the effective management of such conditions. Despite advancements in headache management over the last decade, a...
A significant clinical association between osteoporosis (OP) and fibromyalgia (FM) has been shown in the literature. Given the need for specific biomarkers to improve OP and FM management, common miRNAs might provide promising tracks for future prevention and treatment. The aim of this review is to identify miRNAs described in OP and FM, and dysreg...
Somatoform disorders are difficult to diagnose and, more often than not, complicated to manage. Acupuncture has been proposed as a possible treatment method to treat this form of psychosomatic disorder. The aim of this article is to analyze current studies on this topic to evaluate whether acupuncture can be used effectively to treat patients suffe...
Background
The current systematic review and meta-analysis was conducted to estimate the prevalence of fibromyalgia syndrome (FMS) in Saudi Arabia.
Methods
A PRISMA systematic search appraisal and meta-analysis were conducted. A systematic literature search of English publications in PubMed, Embase, PsycINFO, Web of Science, MEDLINE, and Google Sc...
Effective treatment for fibromyalgia (FM) is lacking and further treatment options are needed. Photobiomodulation therapy (PBMT) represents one potential treatment option. Whilst favourable findings have been reported using localised PBMT, no investigations have established the value of whole-body PBMT for the complete set of symptom domains in FM....
Special Issue Reprint
Chronic Pain: Clinical Updates and Perspectives
Edited By:Carmen M. Galvez-Sánchez
Casandra Isabel Montoro Aguilar
Markus W. Hollmann
mdpi.com/books/pdfview/book/7832
ISBN 978-3-0365-8644-1 (hardback)
ISBN 978-3-0365-8645-8 (PDF)
This reprint provides an essential comprehensive overview of chronic pain research. New research...
Reports of the incidence of fibromyalgia (FM) in Asia are uncommon. Therefore, this study used nationwide representative data to investigate the age- and sex-specific incidence and annual trends of FM in South Korea. This nationwide population-based study used data from the Korean National Health Claims Database. From 2012 to 2021, patients with FM...
Key Clinical Message
Fibromyalgia is a rare disease, difficult to diagnose and to treat. We think that hyperbaric oxygen therapy could improve its signs and symptoms although more evidences have to be accumulated.
![Figure 3. Risk of bias summary [15-22].](publication/373376023/figure/fig1/AS:11431281183707447@1692969902698/Risk-of-bias-summary-15-22_Q320.jpg)
(1) Fibromyalgia (FM) is a chronic musculoskeletal condition with multiple symptoms primarily affecting women. An imbalance in cytokine levels has been observed, suggesting a chronic low-grade inflammation. The main aim of the meta-analysis was to examine the effect of multimodal rehabilitation on cytokine levels and other predominant variables in...
Fibromyalgia syndrome (FMS) is a multifaceted and incapacitating functional pain syndrome characterized by continuous, severe, widespread musculoskeletal pain. FMS is associated with other symptoms such as fatigue, nonrestorative sleep, cognitive/emotional dysfunction, and diminished health-related quality of life. The pathogenesis of FMS is still...
Objective:
To analyze a RheuMetric checklist, which includes four feasible physician 0 to 10 scores for DOCGL, inflammation (DOCINF), damage (DOCDAM), and distress (DOCSTR) for criterion and discriminant validity against standard reference measures.
Methods:
A prospective, cross-sectional assessment was performed at one routine care visit at Liv...
Background: Fibromyalgia (FM) diagnosis is typically based on the American College of Rheuma-tology (ACR) criteria, relying on patient-reported symptoms. The Thai self-reported Fibromyalgia Survey Questionnaire (FSQ) was developed based on the 2016 version of the ACR criteria set. Objectives: This study aimed to evaluate the internal consistency, c...
Functional somatic syndromes (FSS) include fibromyalgia, irritable bowel syndrome (IBS), and others. In FSS patients, merely viewing negative affective pictures can elicit increased physical symptoms. Our aim was to investigate the neural mechanisms underlying such negative affect-induced physical symptoms in FSS patients. Thirty patients with fibr...
Background: People with myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) experience core symptoms of post-exertional malaise, unrefreshing sleep, and cognitive impairment. Despite numbering 0.2-0.4% of the population, no laboratory test is available for their diagnosis, no effective therapy exists for their treatment, and no scientific...
Background:
Chronic pain is a major cause of suffering and disability and is often associated with psychiatric complications. Current treatments carry the risk of severe side effects and may lead to limited or no relief at all in a relevant portion of this patient population. Preliminary evidence suggests that classical psychedelics (e.g. LSD and...
Objective:
The aims were to validate linguistically British-English versions of the Perceived Workplace Support Scale (PWSS), Work Accommodations, Benefits, Policies and Practices Scale (WABPPS), and Work Transitions Index (WTI) in rheumatoid arthritis (RA), axial spondyloarthritis (axSpA), osteoarthritis (OA) and fibromyalgia (FM).
Methods:
The...
Skeletal muscle regeneration relies on the reciprocal interaction between many types of cells. Regenerative capacity may be altered in different disorders. In our study, we investigated whether the deletion of miR-378a (miR-378) affects muscle regeneration. We subjected 6-week-old wild-type (WT) and miR-378 knockout (miR-378–/–) animals to the glyc...
Aim: Autoimmunity, peripheral nerve dysfunction, and neurogenic inflammation are common mechanisms in chronic spontaneous urticaria (CSU) and fibromyalgia syndrome (FMS). We aimed to detect the prevalence of FMS in patients with CSU and to determine whether this prevalence was affected by the severity of urticaria, and dermatology life quality. Mat...
Low back pain is associated with changes in trunk muscle structure and function and motor control impairments. Voluntary force modulation (FM) of trunk muscles is a unique and under-investigated motor control characteristic. One of the reasons for this paucity of evidence is the lack of exploration and publication on the reliability and validity of...
Introdução. A fibromialgia é caracterizada por dor musculoesquelética generalizada, distúrbios do sono, fadiga, cefaleia e sintomas cognitivos. O sistema endocanabinoide parece ter um papel importante na fisiopatologia dessa doença e o uso de fitocanabinoides se apresenta como uma possível opção terapêutica. Objetivo. Avaliar os efeitos da utilizaç...
Background:
It is unknown whether patients with chronic musculoskeletal pain (CMP) show autonomic dysregulation after exercise, and the interventional effects of exercise on the autonomic dysregulation have not been elucidated. The objectives of this study were to reveal acute autonomic responses after aerobic and resistance exercises and the inte...
Fibromyalgia is a chronic pain condition. Mood disorders, sleep problems, fatigue, and temporomandibular disorders can accompany fibromyalgia. The hallmark of fibromyalgia is chronic generalized pain. Yet, numerous diseases can present with generalized pain in older adults. Careful anamnesis and a detailed physical examination are essential to rule...
Fibromyalgia is characterized by widespread pain, fatigue, sleep disturbances, mood disturbances, and cognitive impairment. Most individuals with fibromyalgia experience poorly managed symptoms and increased healthcare service use. Multicomponent therapies, with a focus on nonpharmacological modalities, are increasingly supported in the literature....
Background:
This study was carried out to compare the levels of inflammatory markers in the complete blood count before and after they began receiving duloxetine in patients with fibromyalgia syndrome (FMS).
Methods:
The patient and control groups were composed of 40 patients diagnosed with FMS in accordance with the 2016 American College of Rhe...
Key Clinical Message
While tDCS has been studied as a safe and effective tool for managing pain in fibromyalgia, there is a possibility of triggered long‐lasting mood changes. TDCS may potentially negatively affect mood in specific individuals with fibromyalgia.
Abstract
Transcranial direct current stimulation (tDCS) is a noninvasive neuromodulato...
Introduction
Previous clinical observations raised the possibility that COVID-19 vaccination might trigger a small-fibre neuropathy.
Objectives
In this uncontrolled observational study, we aimed to identify small fibre damage in patients complaining of generalized sensory symptoms and pain after COVID-19 vaccination.
Methods
We collected clinical...
Background
Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood disorder (MDMD), is associated with adverse childhood experiences (ACEs) and negative life events (NLEs) which induce cytokines/chem...
The aim of the present study was to investigate the effects of pregabalin plus exercise vs. pregabalin treatment alone on the electromyographic nociceptive flexion reflex (NFr) threshold in patients with fibromyalgia (FM). For this purpose, the present study included a total of 40 patients diagnosed with FM according to the american College of rheu...
The purpose of the present study was to determine whether self-efficacy mediated the relationship between perceived disease-specific impact and symptoms of depression in a sample of 600 individuals (Mage = 53.92 years, SD = 11.45 years) with fibromyalgia over 18 months. A 1-1-1 longitudinal multilevel mediation analysis was conducted using particip...
Background: In addition to pervasive pain, patients with fibromyalgia also complain about impaired cognitive functions, anxiety, and depression. Objectives: This study was conducted with the aim of comparing the effectiveness of mindfulness-based stress reduction (MBSR) and intensive short-term dynamic psychotherapy (ISTDP) in depression and the se...
Objectives:
This study aimed to examine emotional awareness, control of emotions, and the childhood attachment process in fibromyalgia patients.
Patients and methods:
The observational study was conducted with 117 participants (14 males, 103 females; mean age: 43.9±9.0 years; range, 22 to 64 years) between February 20, 2022, and May 20, 2022. Si...
This study aims to evaluate the effects of acupuncture on pain and health status in women with fibromyalgia. The present randomized, controlled, double-blind clinical trialwas carried out with one sample of 40 women diagnosed with fibromyalgia .They were randomized into one acupuncture group (n = 20; 51.7 ± 6.5 years old) and one sham acupuncture g...
p>fMRI and phenotype data for the PNC dataset came from the Neurodevelopmental Genomics: Trajectories of Complex Phenotypes database of genotypes and phenotypes repository, dbGaP Study Accession ID phs000607.v3.p2. The authors would also like to thank the UK Biobank (UKB application ID 61915), the BSNIP study organizers, and OpenNeuro as well as th...
Musculoskeletal pain and inflammation can vary from localised pain like pain in the shoulders and neck to widespread pain like fibromyalgia, and as per estimates, around 90% of humans have experienced such pain. Oral non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for such conditions but are associated with concerns like ga...
Background
Little is known about depression in SLE. To evaluate the prevalence of depression and associated factors in a large, multicenter SLE cohort (RELESSER-PROS).
Methods
Prospective longitudinal study of SLE patients answering positively to the depression question of the Lupus Impact Tracker (LIT) questionary (question number 7, LITQ7 ‘I was...
Background: Major depressive disorder (MDD) is accompanied by activated neuro-immune pathways, increased physiosomatic and chronic fatigue-fibromyalgia (FF) symptoms. The most severe MDD phenotype, namely major dysmood disorder (MDMD), is associated with adverse childhood experiences (ACEs) and negative life events (NLEs) which induce cytokines/che...
Background:
Fibromyalgia (FM) is characterized by chronic widespread pain, as well as anxiety, sadness, and depression. These symptoms are present in most patients and have a negative impact on their daily, family, and social life. The role of neurotransmitters in the pathophysiology of FM has been extensively discussed. The scientific evidence sh...
