Fibromyalgia - Science topic

Parul from Zydaptive just sent you a full-text request for:Impact of Fibromyalgia Severity on Health Economic Costs

ArticleApplied Health Economics and Health Policy 03/2011; 9(2):125-36., DOI:10.2165/11535250-000000000-00000

Andreas Winkelmann · Serge Perrot · Caroline Schaefer · Kellie Ryan

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I received a text request from Kim Lawson about ketamine in fibromyalgia.

I do not find how to send as I do not have Twitter, nor Kim's email

I’m curious if a newer theory on pain exists or whether we are still attempting to understand the theory fully in order to prove/disprove its correlation.

I understand it was a theory and required research to prove, however I’m not sure how a theory is proved if the medical establishment doesn’t still can’t successfully prevent or reverse the condition. Confirmation of a theory should balance recovery, reversal and management of pain through research studies, not simply pharmacological and pain management. We have severe chronic illnesses that fall distinctly in pain theory territory, for instance fibromyalgia a disease that has been coined “invisible“, abuses ones own body but can’t be tested or resolved and isn’t classified as an autoimmune condition. Yet the common information given to patients is we don’t understand fibromyalgia, nor how to reverse the condition. Some treatments are available to manage individual side effects of illness, generally consisting of seeing multiple disciplinary medical fields.

Central Sensitization Syndrome perhaps is a foundational stone in the theory. However I find it inconceivable with the advent of scientific medical research advancements (funded as part of the covid 19 pandemic), that this disease can continue to be discounted as a type of pandemic of various origins, given it often has certain known triggers ie infectious disease, PTSD And various other illness classifications.

I'm a 3rd-year psychology student at the University of East London and I'm conducting a 10-15 minute anonymous online survey to capture the everyday experience of Fibromyalgia patients and how they feel they are supported by their medical experts for my final year dissertation.

As leading voices for those who experience chronic illness and who may also be diagnosed with fibromyalgia, I would like to request your assistance in reaching those who often lack a voice, to allow me to capture their thoughts and feelings. Can you help me reach the 150 people that I need to complete the survey over the next two months.

As you are aware Fibromyalgia lacks robust research, I very much hope that gathering as many voices as possible through completion of the survey will be an opportunity to start addressing that.

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I need to understand the fibromyalgia tender points and the relation between each other, according to the concept " If they fire together, they wire together". But all what I found by searching was only their positions and some information about pain/ diagnosis/relief,...

So I need a help with any reference even if just an opinion about this issue. Thanks a lot.

My long term study of patients with fibromyalgia and diffuse type 2 occupational overuse syndrome during use of sEMG biofeedback shows that there is a symptomatic difference in pain

during splinting of muscles causing deep ischemic pain and the release of muscle tension which brings about numbness, pins and needles and deep throbbing pain. I am looking for an objective measurement to verify this

I have worked on an animal model to induce fibromyalgia syndrome in rats when I tried to express data of open field test, I found that normal rats had moved fast after putting them in the central area but, in the case of fibromyalgia induced rats, rats had stayed in the center without a significant moving and hadn't gone to the peripheral area. How can I explain what happened to my fibromyalgia induced rats?

I am contributing to local guidelines and my local population has a high Pakistani diaspora (1st and 2nd generations). My experience suggests that they present with more cognitive and mood symptoms than pain. Pain being a secondary concern. Does anyone have any similar experiences or advice?

Hello!

I am looking for a SHORT questionnaire/scale to measure Quality of Life in chronic patients (e.g. fibromyalgia, or multiple sclerosis). Ideally, validated for English and Spanish speakers. Any suggestions?

Thank you so much :)

If the participant is off sick or has a disability due to FM, I imagine the correct answer must be 7. Is it correct? If she works, she marks the days in which has missed work due to FM.

Since the scale refers to the previous week, does this question refer to the impact suffered at work during last week or to the time when she was working?

I couldn’t contact with the authors, so I hope someone will be able to help! :)

Looking to assess the composition and concentration of the micronutrient regimen. Were any individuals with fibromyalgia included? 

after getting the total score of FIQR and different three compartment scores how can I interpret these scores ? how can I correlate them ? is there a certain cut-off value ?? or categorical classification for each score ??

CBD and THC are cannabis sourced moleculs. The use is authorised in some countries. Some associations tends to think that these are the future of fibromialgia treatments. What does the current and serious researchs actually says ?

Would you consider/ have experience with Duloxetine for Fibromyalgia in Systemic Lupus Erythematosus (SLE) patients?

Or for depression/ anxiety in SLE patients?

Are there any reported effects in these patients in regard to fatigue?

Does anyone have experience in the application of TMS in the following syndromes:

-fibromyalgia

-tinnitus

-tension-type headache.

Hello:

I have two doubts I hope anyone can help me with :)

1. Is there an actual difference between descriptive and interpretative phenomenology?

2. I am developing a mixed methods project with sequential exploratory design in which the results of the qualitative phase will serve to the development of an intervention that will be tested trought a quantitative phase. So, the objective of the QUAL phase is to explore how patients with fibromyalgia experience pain and poor sleep quality. Mainly, my objetive is to focus on the cognitive (meaning) and behavioral (symptom management strategies) factors related with pain and sleep in the context of fibromyalgia. DO YOU THINK A DESCRIPTIVE PHENOMENOLOGICAL INQUIRY WOULD BE APPROPRIATE?

Thank you :)

I am reviewing about fibromyalgia syndrome. Any specific standardized scale for assessment if present, please suggest.

It has been discovered that microglias plays a key role in chronic pain related diseases such as Fibromyalgia. Some therapetic strategies are studied, such as Naltrexone that binds to Toll-Like Receptor 4 or Cannabidiol that is an indirect inverse agonist or Cannabioid Receptors. What are the different receptors expressed by microglias that are linked with chronic pain ?

My lab uses commercially available ELISAs for human IL6 in serum. We have some fibromyalgia and Parkinson's disease human serum samples. For those two conditions, it has been reported elevated levels of IL6 in serum.

However, we couldn't detect any meaningful levels of serum IL6 in those patients. We have tried with two different company's ELISA kits (Thermo, and Ray Biotech) and one multiplex ELISA (Millipore), but couldn't figure out why the levels were undetectable.

We think this might be the levels of IL6 in serum is too low, which can't be measurable by common ELISAs. But, other studies in the literature seemed to find values quite easily from commercially available ELISAs. So, our second thought was some interaction between IL6 and serum matrix (or IL6 receptor, or unknown protein complex that hides the binding site of the antibody of ELISAs). Another thing might be some sample prep or transportation, but whenever we got samples, we aliquoted them and stored them at -80C right away.

Has anyone experienced anything similar? We've asked this to one of the ELISA companies. What a funny thing was that they said they weren't able to measure any levels of IL6 in serum in healthy controls (I don't know why they are selling their products.. haha..), but they have no results for fibromyalgia or Parkinson's disease.

Thanks!

Strong fibromyalgia can be very hard to live with.

Is there interesting findings that can show some hope for patients ?

I am looking for more qualitative information on fibromyalgia patients experiences of secondary care medical professionals.

Many patients with fibromyalgia are under diagnosed and under treated. Lyrica is becoming very popular as a treatment option but a significant number of persons cannot tolerate the side effects like drowsiness, light headedness etc. What other treatment option are available?

I am an italian student and i am writing a thesis about the efficacy of DIT on Fibromyalgia patients.

 I have long thought there is a lot of information on "Pain"  which by definition has to have crossed a threshold to become cognitively experienced. 

However, using palpations such as Janet Travel taught, i see children who declare no pain, but leap when cranial and facial trigger points are pressed. 

I am not having much luck in finding research on the cumulative effects of this.  I suspect there must be many physiological processes involved in this sub-conscious level of  'almost' pain. 

David Zimmerman

How are the autonomic regulation of the heart rate and other functions of the human body-the tone of the vessels, respiration, intestines, endocrine glands, etc., related to each other?

Since my early career research focused on the search for biomarkers, particularly red blood cell Li-Na countertransport levels in bipolar patients and alcoholic patients, and many of my bipolar patients also had clinical complaints consistent with what is now called fibromyalgia; and my mid-career research focused more on the epidemiology and mental health aspects of HIV infection, through the Multicenter AIDS Cohort Study (the MACS), it is interesting to see other researchers interested in immune function in both affective disorders and fibromyalgia. Have you or any other researchers following your research also seen similarities in the immune profiles of patients with bipolar disorder and fibromyalgia and the state-dependent changes in immune markers?

I had two patients with anal pain, probably proctalgia or anodynie with reporting of a burning or painfull sensation in the foot, mostly the sole.

I am doing a qualitative report on what it is like to have Fibromyalgia. I plan on doing this research at the pain clinic at Rochester, MN. The sampling strategy will be a deliberate sampling strategy. I will be choosing participants from chronic pain patients circa twenty to thirty applicants. The criteria will be Fibromyalgia for at least one year.

Fatigue is, at least for SLE patients, one of the most important symptoms that interferes with daily activities or work. Apart from control of disease activity, what is your preferred treatment option? Do you use stimulants? 

Need to measure function instead of pain intensity in adolescents with fibromyalgia, migraines, chronic musculoskeletal pain, abd pain

I am looking for articles regarding celibacy (involuntary) and medical risks/outcomes. Particularly studies of RA, Fibromyalgia, and pain management. Main question: Does long term involuntary celibacy lead to negative health outcomes?

obviously theres a group of CFS'ERS AND ME/CFS'ERS that didn't get ill from viruses but instead became seceptable to them and re-activation of them and some were made ill by chemical exposures, now MCS and the sinus,olfactory,brain pathway, I think shows a whole other impact to the brain besides the stomach/bowel route. GWI has been reconized as TBI/PTSD, YET THERES STILL SO LITTLE POINTING TO THE SEVERITY OF BRAIN DAMAGE that turned my world upside down when I too fit into this box , I cant tell when my brain is affected by either route and no not all ME/CFS'ERS have the sinus/brain involvement witch is looking to not only be related to chronic rhinosinusitis but very possably severe Fibromyalgia.  I know we are getting there but gee, kind of would like to see it happen before I croak! obviously there are some in the know out there yet it seems limited to GWI research, very thankful for that but hey some of us are not GWV'S yet suffer from the same cause "chemical exposure" there's a few new articles out on MCS , one that addresses the hearing dysfunctions, can we get more articles out there that point to chemical exposures  and the tipping point (what I call it) where mast cells may suppress the immune system when they cant keep up and this allows  mucosal and tissue damage and infection to acure and not only play a role in autoimmunity but probably also the B cell switching to IgE. I can relate to both GWI and Autism ,have tried to keep up with research on both.

It appears to us that the literature treating of Fibromyalgia and Mg efficacy has been derided in the literature as deriving from poorly-designed studies. We need more studies, shelved or not, to feed our greedy statistical monster for a meta-analysis proposal. 

Fibrofog is a particular form of cognitive impairment descripted in patients affected by Primary Fibromyalgia . The cognitive pattern of Fibrofog is very different from the Alzheimer cognitive pattern (attentional memory versus episodic memory, for example....). 

Whats the latest evidence on the role of dietary factors in fibromyalgia? anybody working in this area?

Anyone know what relationship Hypercholesterolemia with fibromyalgia?

A female patient who is 25 years old and healthy, has been presenting with right upper abdominal pain periodically for years. This pain was very seldom until a traumatic experience over a year ago. At this time, the pain became more frequent. A year ago, ultrasound showed gallbladder sludge and a HIDA scan refraction of 52%. A year later, patient developed nausea and vomiting along with increased pain. New ultrasound images showed a gallbladder polyp and a HIDA scan refraction of 30%. Testing also showed slight gastroparesis. Patient has a high family history of gallbladder disease especially in young women. She also has fibromyalgia which her rhuematologist has noted her to feel symptomatic before test results show up for multiple issues. Would gallbladder removal be the best first step? (Please note, medical system being used is known for delaying treatment to the point where some patients cannot recover unless a patient advocates for his or her self.)

The association/ correlation/ <relationship between allergy and anxiety involves states rather than only traits, > - yes, it's there, and it's deeper than people know.

From an individual viewpoint: what doctors call 'anxiety' is often just 'agitation', and correlates with physiological agitation, which they call 'hyperactive' or 'reactive' or 'allergic' (depending on their chosen markers)... these are just names, names for high-energy function, or 'high-function' or 'sur-vival' function. There is another way of looking at this, without the partial names.

These "states" that "change" are exactly what a basic geometric modelling can describe effectively, as a fluid modification or distorsion; this why I developed a method of 'basic topology' for this (topology describes distorsions, large & trans-Formative in mathematical topology, small in geometric topology, with deformation).

The many triggers can be physical or human, external or internal, and their variety, like the many names, can be categorised systematically (using logical 'perspectives'); I developed a method for this too; the whole they constitute is an 'Ecology of Health'.

The changing states may become set as traits and this involves certain topologic properties. This is linked to notions of 'dose related effects' (with "paradoxes" such as that of Serotonin reactions), and to notions of reversible or irreversible linked to a process similar to wormholes in physics (passing through a double-sided surface, described also in ancient traditions, with archaic words, and earlier with images of a geometric style). Details of triggers can take forever to map intellectually, and individually require an uncommon degree of self-awareness (sensing one's physiological reactions after noticing influences external and internal), so a higher-order logic using 'perspectival' categorisation for qualitative description and basic geometric topology for modelling how it works is quicker, shows both origins and ends of the developing symptoms, also in a more general way as applied to the drift in human health (and sanity and supposedly non-animal behaviour); it leads to find options more easily, and requires far less research budgets. Yet none at all is devoted to this.

-patient diagnosed with fibromyalgia

-tooth 35 was treated endodontically because of pain (altough the vitality tests were normal)

-patient still feels pain that evolved into a pain on percussion

Have read various articles, but have so far found deviance between studies and results. Some studies say there is a connection, others not. At the very least, fibromyalgia patients seem to have a higher prevalence of thyroid disease and vice versa

I am looking for a validated tool that can identify muscle pain or myalgias as major predominat factor in chronic pain patients? Are there any such questionairres used in fibromyalgia research for example? 

Young woman with fibromyalgia syndrome presented with significant postural hypotension and severe intractable headache and anxiety.

As a general practitionner mostly, and holding a vacation in a pain unit in hospital, I frequently ask myself which is the impact of telling to a patient "you have fribomyalgia" on further care, knowing that there is no specific treatment for this syndrome about which we have no proof of a specific disease reality.

I found only one study on Pubmed :http://www.ncbi.nlm.nih.gov/pubmed/12115155?log$=activity

One of our student want to make his end of studies research on this theme, but we don't have the capacity of making a cohort. We are searching if there is a study design that would allows us to help to answer this question, may be somebody here has an idea ?

I would like to include a patient in my walking program. However, he has fibromyalgia and experiences pain in his legs. Can he still gets benefits from walking? What training recommendations would you make?

I am getting reading for my dissertation and need some guidance. Thank you.

I need to know the prevalence of Fibromyalgia in Dutch society. Any information or suggested literature?

Low blood pressure (neurally mediated hypotension) is common in many fibromyalgia patients. Neurally mediated hypotension (NMH) occurs when there is an abnormal reflex interaction between the heart and the brain, both of which usually are structurally normal. NMH is also known by the following names: the fainting reflex, neurocardiogenic syncope, vasodepressor syncope, the vaso-vagal reflex, and autonomic dysfunction.

I want to uncover the newest ways of alleviating the symptoms of Fibromyalgia.

The fact is there's little scientific evidence to support any single eating plan as a way to deal with fibromyalgia. Nevertheless, a trip around the Internet will show that dietary approaches to fibromyalgia abound, is there any basis for dietary management?

Diet and Fibromyalgia.

A neighborhood magazine featured a story on MTHFR mutants and the regulation of folate. According to the article, Fibromyalgia is on of the syndromes associated with MTHFR gene mutations. Any validity to this?

Some researchers believe it's the constant pain of fibromyalgia that causes sleep interruptions. Others have found evidence that fibromyalgia may be related to an abnormality of deep sleep.

An article in the Wall St Journal published yesterday spotlighted the huge increase in cases of heartburn in the U.S. However a large subset of modern patients are unresponsive to the standard of care Proton-pump inhibitors and when endoscopies are carried out there is little sign of acid erosion. Because of this the condition is being dubbed non-erosive reflux disease - or NERD - which experts believe accounts for 50% to 70% of patients with gastroesophageal reflux disease (GERD), the classic cause of heartburn.

My question: is NERD just irritable bowel syndrome (IBS) of the esophagus?

According to the article NERD patients are younger and more frequently female- the population most at risk of IBS. NERD patients have the symptoms of GERD but without evidence of tissue damage/ IBS patients have the symptoms of Irritable bowel disease (IBD) but without the tissue damage.

NERD and IBS are both diagnosed by a process of elimination and dubbed 'functional disorders.'

In both NERD and IBS stress is a leading factor. Traditional medications do not work but trycyclic antidepressants can offer some relief.

They are modern conditions on the rise, but with an unknown etiology. Is it the same disorder affecting divergent regions of the G.I. Tract? And if so what common denominator is the cause?

Vitamin D deficiency has been reported as being common in fibromyalgia and occurs more frequently in patients with anxiety and depression.

Evidence also suggests that cognitive-behavioral therapy can help some patients with fibromyalgia.

I need to give the most effective ttt from the musculoskeletal physiotherpy point of view. Thanks in advance

Some researchers have shown that fibromyalgia sufferers can not reach the most important level four sleep.

I am interested in the use of acupuncture in the management of fibromyalgia patients... any leads or experiences please post!