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Fetal Development - Science topic

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I'm trying to develop a paper concerning the use of ART in HIV positive and negative pregnant women and how that has effected fetal development.
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Hi. Many small steps. Biggest was World Health Organization (WHO) proposing 'Test & Treat' for all HIV infections, irrespective of CD4 count (R Granich et al. Lancet Jan 2009). Their mathematic model was in response to A South African request to investigate a 3-fold difference in reported HIV incidence in SA (2007).
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What are the main differences between chronic hypertension and gestational hypertension in fetal growth? Do these babies grow differently?
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Absolutely correct
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Hello fellow nerds,
A food for thought question that I would love others opinion on.
At what stage of fetal development, is the fetal cell count equal to half the cell count of a newborn.
This question stemmed from a thought experiment: if we were only looking at cell count when is fetal development halfway.
Assume GA 38.6
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28 to 30 weeks
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Is 8th week the earliest week where we can determine the fetal sex ?
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Early detection can be through DNA based testing like cell free fetal DNA in maternal blood but later usual method mostly used is ultrasonography. However, there can be restrictions to fetal sex determination in some countries like India. Preimplantation genetic diagnosis provides the answer in planned pregnancies in specific situations Masharudin Abdul Wahab and Ashish Poudel
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Unbooked primigravida diagnosed with diabetes mellitus of 3 years duration and defaulted on taking her medication, presented with IUGR, was delivered of female infant of 1.7 kg at term. The mother has no renal pathology and the baby has no congenital anomaly.
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vasculopathy due to DM
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A very broad statement deliberately structured as an "open probe" to survey think on the subject on the way to a detailed analysis. Does the fetus "think", sense, learn, dream, develop complex behaviours through learning. How would one measure such function in utero? Go for it!!
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Hello, all.
I am planning to make a survey concerning toxoplasmosis and its influence on human society. To perform the survey I also need data about the first birth age of women (usual time for toxoplasma test) in different countries, since Toxoplasma prevalence grow with age. However I could not find such data about Iran. Even Google, UN and CIA together cannot shed light on this problem. Perhaps, I've missed something. Can anybody tell me, where I can find these data?
Thank you in advance,
Misha
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No. Only the mean childbearing age.
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I study amino acid transport through (and synthesis by) placenta in different species.
I found the data about paired dam-fetus serum (plasma) content of AA in horse, sheep, pig etc but not in cow. The only paper dates from 1979 (DEMIGNÉ et al.)
Does anyone have any suggestion regarding a recent study of dam-fetus serum (plasma) concentrations of AA in cows?
Thank you.
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You should see this paper " Materno-foetal exchanges and utilisation of nutrients by the foetus: comparison between species.
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In medical imaging we are using ultrasound for detecting abnormalities in unborn babies. Can we do same by USCT?
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No of course because of the radiation hazards
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I'm trying to find information on how to compare developmental stages between mice and humans. There are nice overviews on comparing mouse embryological stages to human gestational weeks (eg carnegie stages).
What I miss and can't seem to find anywhere, is a comparison between mouse postnatal and human gestational weeks. Does anyone have any info on this? Thank you.
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Thank you for your answers. Fred Sinowatz I am afraid you are right. Will have to find another way!
Best wishes,
Edward
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I am wondering what specific hormones the fetus may use to signal its condition/needs to the mother and alter her biology to meet these needs. 
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Your question asked what hormones are secreted by the fetus (the embryo does not secrete hormones ) but the citation you posted yesterday only mentions hormones secreted by the placenta. Please clarify.
Placenta. 2017 Jun;54:83-88.
Review: Fetal-maternal communication via extracellular vesicles - Implications for complications of pregnancies.
The human placenta is an organ that serves as the interface between the maternal and fetal circulation, thereby supplying the fetus with nutrients, blood and oxygen through the umbilical cord. During gestation, the placenta continuously releases several molecules into maternal circulation, including hormones, proteins, RNA and DNA. Interestingly, the presence of extracellular vesicles (EVs) of placental origin has been identified in maternal circulation across gestation.
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I was wondering if anyone knew of a situation where a mother became infected with rabies, when pregnant with a viable fetus. If the fetus could be delivered prematurely, would it also have the disease? What sort of impact would that have/ did that have on the child's neurological development? Does anyone have any recommended reading on this subject?
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Hello: Can anyone pls help me to identify an available data set on prostate cancer and birth characteristics (gestational age, birth weight, birth length, time to puberty etc)? 
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I believe there is a genetic component here. I found what I was looking for - thank you!
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It is already know variations in the circle of willis are associated with intracranial aneurysm formation due to change in the hemodynamic flow. I would like to know what is the likelihood of a patients with UIA, to rupture if he has a variation in the circle of willis, whats is the risk of this aneurysm get rupture. 
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Breast milk has a clear effect on the development of bones and muscles of the newborn.
but are there any clear data showing if due to breastfeeding bones develop first? or muscles develop first? (Or aster than one another) ? Or Together (at the same rate)
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Here are are a couple of articles that should give you some info:
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I wish to determine the main sub-events on a traces. However, They are usually overlapped and some simple method like finding local maximum is easily defaulted by a small noise added on a main pulse. I think maybe I should get the envelop first and then find the main sub-events orderly. Do you have better idea about how to do it automatically and efficiently?
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You might apply some filtering (eg. Median - or low-pass) prior searching for local maximums. Depending on the amount of noise present the filter might do the trick.
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i just want to ask the action of body immune system against the embryo before and after placenta formation.
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I agree with  Dr Khalid  
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can anyone give me examples of its toxicity and can it be rank from its severity?
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Dear in clinical and pre clinical is clear due to pathogenicity and causes
the maternal toxicity the cause due to dam toxicities that may be cause both fetotoxicity and teratogenicity; the fetotoxicity, the fetus is not die may be cause teratogenicity clinically or laboratory .... in coniclued that terms flow sequence each cause and pathogenicity
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All of we know that brest feeding have a great role on neonatal health but my concern is now a days we can see mothers are using formula milk and their babies are also fine. Then is it the time to re think.
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@Anthony G Gordon,
It is possible that bottle feeding position has an effect on infant morbiditity, particularly otitis media which is higher among formula fed than breast fed infants (though this may be due to the sucking mechanism of bottles which is different to at breast - this is not known).
However, you assert that clean water has no impact on neonatal mortality in formula fed infants, only feeding position. If this were true then we would expect to see the same rates of neonatal deaths among formula fed infants everywhere in the world, regardless of the access to clean water because as far as I know, nowhere has a regime of publicly promoting upright formula feeding. This is not the case. Formula fed infants in parts of the world without easy access to clean drinking waters, and post disasters are at far greater risk of GI infections than formula fed babies where clean water is accessible.
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-  Is early appearance of alpha waves have any significance in infants maturity?
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Thank you Zeashan,
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early pregnancy diagnosis in goats
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Transrectal diagnosis can be performed using a scanner with a 7.5 MHz transducer. The 7.5 MHz has a penetration of 5-7cm, meanwhile the 5 MHz has 10-17 cm deepness and the 3.5 MHz 17-20 cm.
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What is the current progress in science and philosophy regarding definitions of a human being at fetus stage and relation to consciousness? 
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I cannot answer your question without wild speculation but the article below may be of interest for an answer to your question:
Bjorn Merker (2007). Consciousness without a cerebral cortex: A challenge for neuroscience and medicine.
Journal: Behavioral and Brain Sciences, 2007. (Look the issue up; there are several interesting comments on this lead-artcle.
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DW MRI better to differentiate fibroids from adenomyosis on way of restricted water in adenomyosis than fibroids 
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Hi Kassmin. More details of the aim of the study would help to refine the answer. Which are the end points to be evaluated in the study, which are the subjects and the methods to be used?. 
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Microcephaly is a rare side effect in these cases. I need to know exactly how rare.
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You should retract that assertion as it may be libelous.I am simply trying to get an answer to a medico-legal question
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In South Asian countries, it is a common trend that after childbirth, women press the forehead and also backside of the skull to give it specific shape. Do it has any effect on the brain function/number of neurons?
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I have heard about this old practice.  It was ascribed  to the beauty.  The shape of skull - brachiecephalic or dolichocephalic  - is determined the  genes.
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The context is, Gene-Nutrient interactions in fetal development and onset of chronic diseases
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The embryonic and fetal cells have a complex system to integrate nutritional signals from their environment and adapt their development (possible involvement in the prenatal programming of glucose metabolism in the adult) accordingly to ensure "survival". In the case of inborn errors of metabolism, nutrition in the first years of life is a key determinant of health or disease status. Additionally, the relationship between CVD factors (plasma lipid content) and gene-diet interaction could be an example of long-term consequences due to its heritability
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I’m making research about the possibility of fetus hearing perception (in terms of Hz).
We know that the future baby has a important preference to the mother’s voice. This voice arrive to the fetus by the spinal column and the sound is very high in tone.
Due to the fact that high tones are stimulating for human metabolism, fetus hears ultrasound and, from the other side, people older than 30-40 years are not yet able to hear more than 15-17 KHz, the question is:
Is it possible that the fetus has a specific Hz range hearing, able to listen to very high frequency like ultrasound and this capacity slowly disappears in perinatal life?
I’d like to listen to your opinion, that I consider very important for me.
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According to 'Development of fetal hearing' by Peter G Hepper and B Sara Shahidullah, the high frequency range you are interested in was not considered in this study however it says that early in gestation 'none responded to the 1000 Hz and 3000 Hz tones'...so one can extrapolate...but it is all about hearing perception.
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Has anyone any experience of this or seen articles relating to it?
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I have not found women to be able to determine whether the fetus is breech vs vertex by where they feel fetal movement.  It is fairly reliable at term to ask if they have urinary urgency- because that means the head is down i.e. the fetus  is vertex.  I have not had women with breech babies feel strong urinary urgency in the last week, like the vertex babies cause.  
it would be interesting to determine if women feel less movement when the placenta is in the front vs.  in the back or on the side.     But fetal movement is very individual and really the results will reflect that every woman perceives it differently.  For a good example of different perceptions of fetal movement,    Quickening happens between 14 and 21 weeks- which reflects how  differently women perceive fetal movement .   And amazingly, another example of the variation in how women feel fetal movement is - the reason decreased fetal movement cannot be used as an indication of fetal distress, or fetal death,  is because in the research on TERM STILLBIRTH, 25% of women were still feeling  movement after the fetus had already died.     Well perhaps it does float around  or something but it is not moving its own body.  
So, ultimately, there cannot be objective research on this topic.  It would be like researching how different people perceive the color Yellow.     Cannot be done. 
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How reliable is visual determination of the Signal intensity of fetal lung in diagnosing hypoplastic changes?
Can quantitative (ROI) measurements of fetal lung signal intensity and ratios with other fetal structures (amniotic fluid, muscles)  help in assessment of fetal lung maturity??
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This is an interesting research area, however, it will not be cost effective in many human populations.  Signal intensity processing equipment also tend to be quite expensive and not readily available.
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uterine or umbilical artery Doppler
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Thanks for your explanation Igor
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 what is better for manegment off unruptured ectopic pregnancy ? salpigiotomy or salpingiostomy ? 
#gynecology > obstetris > ectopic pregnany 
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laparoscopic salpingostomy is the best option for those cases
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What signals or mediators might be involved ?
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In humans, the placenta is usually a single disc. The umbilical vessels usually travel on the surface from the umbilical cord insertion out to, and return from, the cotyledons. The cotyledons are the functional units of the placenta, and each interacts with the blood vessels of the uterus. As the umbilical vessels reach the center of a cotyledon, they dive into the center and arborize until they form the fetal vessels that are close to the maternal vessels and exchange metabolites and oxygen. I do not know genetic or other signals that control the formation of the cotyledons. Sounds like an interesting research topic!
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Alpha - fetoprotein is an alpha-globulin produced by embryonic hepatocytes and present in normal fetus and new born during the first days of life. But, in serum, high level is encountered in children with various neoplasia including emryonic carcinoma, vitelline tumor, teratoma and 2/3 of malignant epithelial hepatic neoplasia.
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Thanks! Dear Yoshida for your observation, but, have you any analysis of alpha fetoprotein in the evolution of any of those patients that developed tumor even above 70yrs? 
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Would it be too early in terms of developmental stage?
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Thank you very much for the information! That's very helpful!
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 In which histological stage of placentation, the placenta start to work physiological as a well-developed type. Please if you have information on experimental animals such as rat, hamsters or mice please added. during implantation, the embryo nourished through diffusion. during that time the other site of placentation building up the placentation cone. At which histological stage this placentation cone start to make nourishment from maternal through fetal passing though the fetal-maternal barrier. which materials can pass through. I meant only fluids or  cells, viruses, parasites can pass through or it depends on biology of pathogen.
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In the mouse, the placenta-proper starts to function at embryonic (E) day 10.5 when nutrients, gases and wastes are exchanged in earnest between the fetal and maternal blood circulations in the labyrinth layer of the placenta. We know this because many mouse lines with mutations in genes necessary for the early stages of placental development die at E10.5. This is when the embryo becomes too big and can no longer support itself through diffusion through the yolk sac. A review that you might find useful that discusses mouse placental development is: Watson and Cross, 2005. Development of structures and transport functions in the mouse placenta. Physiology 20: 180-93. 
The rat placenta is similar, though the embryonic stage might be slightly later. I'm unfamiliar with the hamster placenta.
I hope that this helps.
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It is interesting to know, the authors well know about of the biology of the human fetus? Physiology of human pregnancy is that between the fetus and the mother's body, there is a organ that up to 24 perform of the function of the endocrine system of the fetus, that is the placenta. This is the first thing. Secondly to maintain a normal pregnancy need huge concentration of estrogen and progesterone, but androgens are not, the content of which is negligible (if at all they circulate in the blood of the fetus) during pregnancy. That is why the male fetus in contrast to in the female fetuses for at least of the period of fetal development and several years after spermatogenesis is not occurs, as it requires at least a minimum amount of androgens. That's why when any threats abortion obstetricians artificially increases the concentration of estrogens and progestins in pregnant women to prevent miscarriage. Third, start the production of hormones in fetus begins only at 20-24 weeks of development, after maturation of the pituitary gland, which is coincident with the first of brain potentials. And at the end, placenta - a powerful factor in hormone metabolism and almost all steroids and androgens generally transformed by aromatase necessary to maintain pregnancy in estrogens. Therefore, the big question is level of which hormones increases by congenital adrenal hyperplasia of fetus? What kind of estrogen-androgen balance is all about? But hypotheses is the hypotheses, whatever it was.
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From FETAL AND NEONATAL PHYSIOLOGY Volume 2 PN 9996076415 FOURTH EDITION 2011, p. 319:  (hopefully this helps)
 Gonadal sex steroids exert an important influence on the pubertal growth spurt, but absence of these factors is not noticeable in prepubertal growth.197 But even in early life, gonadal and adrenal sex steroids in excess can cause a sharp increase in growth rate as well as the premature appearance and progression of secondary sexual features. Sex steroids exert a direct effect on long bone growth, mainly through conversion to estrogen, and can increase GH secretion, once GH receptors are present in adequate supply. Untreated virilizing congenital adrenal hyperplasia is compatible with survival, sometimes for years, as long as severe hypoglycemia or shock does not develop; in those children who have achieved such a state of stability, growth acceleration may occur early in infancy; if the adrenopathy also is of the salt-losing type, the failure to thrive will mask any tendency toward increased growth rate, and the child will grow poorly until treatment is supplied or the child dies from hyponatremia, hyperkalemia, and hypoglycemic shock. Familial Leydig and germinal cell maturation may also cause increased growth early in the first year. If unabated, increased sex steroids will cause advancement of skeletal age, premature epiphyseal fusion, and short adult stature. Thus, just as growth deceleration requires evaluation, growth acceleration can be just as abnormal and may be a sign of precocious puberty or virilizing congenital adrenal hyperplasia
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I want to know that how CSF, White matter, grey matter, skull , skull - fetal brain boundary and CSF-fetal brain boundary are looking in fetal brain MRI.
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Maternal nutrition affects fetal development, and one important dietary determinant of fetal growth may be TFAs. TFAs may block the placental transfer of omega-3 fatty acids to the fetus or disrupt their metabolism. The purpose of this analysis was to examine the association between TFA consumption during pregnancy and fetal growth among
infants born at term in a Spanish population.
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Gracias por tu ofrecimiento Rafa.
En mi tesis una escala de estrés, ansiedad validada por Goldenberg con resultados significativos en el peso al nacer.
Fue traducida por un nativo y vuelta a traducir del castellano al inglés por otro para observar las diferencias.
Te la adjunto por si fuera de tu interés.
Un saludo.
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It has been postulated and shown in some studies that fetal noise exposure and that of the expectant mother may cause fetal hearing loss and secondary effects. I am looking for current research in this area.
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There is human data that low-frequency noise exposure in pregnancy is associated with higher rates of high-frequency hearing loss in children, suggesting damage occurs in utero. However, it is hard to split prenatal and postnatal noise exposures (Lalande was lead author).
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What is the incidence of missed abortion and positive consinguanity?
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Well that depends of some demographic factors. In communities were the genetical variation is not high (for example the Omani population) There is not significant difference between cosanguineous and non-cosanguineous marriage. But in more heterogeneus populations (http://paa2012.princeton.edu/papers/121292) misscarriage, abortions and pregnancy problems have a higher prevalence in cosaguineous marriages.
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Do not reply with any comments on adult murine morphology. So, I have H&E cuts of P1(day one after birth) lungs. However, although I did not collect any LIVER tissue, I have what looks like cuts of mature lung tissue alongside some "liver looking" tissues. This has been seen in 4 separate samples from 4 mice. Anyone have experience with Day1 lung tissue and potentially heterogeneous structures? I know what alveolar sacs look like and the samples contain those structures, similar to adult lungs, however, it looks like they contain sections of preemie collapsed or undeveloped dense tissue. Anyone have experience on this?
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Atelectasis may be an effect of the euthanasia with CO2
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In animal models (ovine) FGR leads to fetal decreased insulin levels. In human infants we sometimes observe severe hypoglycaemia associated with high insulin levels in these infants from quite early on.
Do we know what the cord insulin levels are in a suitably characterised group of human infants? I can only find a few studies with either extreme babies or very small numbers or older stuff with mixed or poorly defined aetiology/pathology.
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What an interesting question. My fellow just reviewed the FGR last week but I am still relatively confusing about the role of insulin in fetal growth. Judging from different animal models it seems insulin plays different role in different species when I looked into the slide my fellow presented. I have looked into IGF1 in monochorionic twins almost 20 years ago, but not insulin levels, and was amazed that though the weights were so different their IGF1 levels were very similar. Maybe study the cord insulin levels in TTTS will provide more useful information to your question.