Questions related to Eye Diseases
Is there any study showing that computer work causes increased eye pressure, a symptom representative of Glaucoma?
I have personally talked with several eye doctors, but they told me that it had not been proven so far. So, I am seeking such new researchers in this regard.
I need these images preferable with labelling done for different parts of the eye. Also some animations, graphics, videos would be helpful. I need these to create eLearning Modules for basic training about Eye, Anatomy and Physiology, Eye Disease conditions for Medical Sales Representatives.
Several months ago we observed some strange changes around eyes of several individual Siberian hamsters (Phodopus sungorus) in our colony (outbred). I attach pictures. It looks like an irritation-induced change, but we think that it is rather a symptom of disease. In some hamsters, which were kept in sibling pairs the change appeared in one individual, but not in the other. Being advised by our veterinarian we were treating hamsters with antibiotics (enfloxacin - in water, gentamycin - topically), but the treatment was not effective. The change appears only around eyes. BTW, except for this irritation-like change hamsters are in good shape. No body mass loss, fur in good shape.
I would like to ask if anyone has an idea what it can be you ever seen anything like that in your hamsters? Do you have any clue what it could be, and if so how to treat it?
We will be grateful for your help, Michal et al.
I am working on a Diagnostic tool to help ophthalmologists diagnose Eye Diseases (like Keratitis) . The idea is to upload a picture of the eye and let the python program isolate the features / Lesions from the uploaded picture and present it as output for the Opthalmologist to consider.
Many people use lenses in order to experience different eye color & also instead of glasses and etc.
It is important to bring lenses out of the eye ,daily otherwise side effects happen like dry eye disease.
So these lenses can be useful.
Is it possible?
In clinics, we often observe different measures of IOP in myosis vs midriasis. What do you think about this procedure and why?
IT is a picture of the fundus. I am not sure about what is this indicative of and what landmarks should I take into consideration. I have acquired a lot of such images but I am not able to interpret them.
As I said I am working on eye disorders and I found a mutation in a gene which does minor alteration that is a change from leucine to isoleucine, which does not affect the function of protein. Instead I am suspecting at the alteration in regulatory elements. Suggest some Insilico tools to analyse the same. I would like to know computation tools, to analyse change in the regulatory elements due to point mutations. I hope you got my point. I have found a point mutation, which is a causative for an eye disease, the change at aminoacid level does not affect the protein function. Hence wish to know whether it alters the transcription by affecting the regulatory elements and also in post transcription, and whether it affects the stability or it activates any long non coding RNA. Could anyone suggest some online tool to analyze these? And also to pick up cell specific gene expression.
I conducted my research on Corneal Neovascularization (eye disease). we used biofunctional compounds of plants and these compounds showed remarkable inhibition of CNV with out any side effects, i used rabbit as an animal model.
VA is Hand movements
IOP is 14 mmHg
B-scan shows flat retina, no tumor and a separate compartment in staphyloma connected to the main eyeball.
Video of this patient is attached to show site of staphyloma which is involving inferior half of cornea and sclera.
My friend's nephew in India had ROP stage 5 and has lost his vision. He is age 13 now. We are trying to find a way where he can get his vision.We are seeing different publications online, but not sure how to proceed
1) This article http://www.omicsonline.org/stem-cell-therapy-for-retinopathy-of-prematurity-2161-0940.1000126.php?aid=21413 says it is is possible.
2) I saw this video https://vimeo.com/2962835 where they said they got the treatment. We are not sure if it is marketing or genuine.
3) We are only following the research happening in https://clinicaltrials.gov/.
We will be happy to send medical reports to anyone who can help us? We appreciate all your help.
Those who treat patients with glaucoma, know that many patients that are on glaucoma treatment, really don`t have glaucoma. As in many other chronic diseases, overdiagnosis and overtreatment are big problems in glaucoma. Nevertheless very few publications have addressed this issue.
Which strategies should be implemented to reduce the problem of overdiagnosis in glaucoma?
We need a young and updated researcher in the field of eye research. We need his/her clinical knowledge to complete our discussion section in a manuscript pertinent to eye and ophthalmology. Please contact me for further information.
I understand this to be an ocular irritation related protective mechanism resulting in a reduced upper eyelid position. However, I have had difficulty finding any publications that describe corneal irritation with resulting blepharoptosis. Does anyone have a reference for this condition?
Is anyone aware of any reliable and precise methods for estimates of choroidal thickness using SS-OCT given that both currently used manual (point measurements) as well as automatic algorithms(built in) have their own inherent errors in measurements?
if let's say the patient is having an cylindrical axis of 90 and they have been corrected at 90 as well. Does the other meridians of the eye was being corrected at the same time as well? I can't find any journal or link about this. please help... thank you so much!
Globally, the magnitude of occurrences of Pterygium is over 200 million people and the prevalence varies between 0.3 % and 37%.[i] The fact remains that ocular disorders are caused by the reflected solar radiation from the surface of the earth especially the white and shining surfaces such as snow and water. [ii]
My question is what percentage of Out Patient cases in hospital undergo surgeries?
[i] Lu P, Chen XM., Prevalence and risk factors of pterygium. Int J Ophthalmol 2009;2(1):82-85
[ii] Bergmanson JP, Soderberg PG. The Significance for Ultraviolet Radiation for Eye Diseases. A review with comments on the efficacy of UV Blocking Contact Lenses. Ophtahlmic Physiol.Opt. 1995; 15: 83-91.
I am currently writing a literature review about sucrose as an intervention during ROP examination. I believe in some NICU’s RetCam is used, in others it is not. There is somewhat conflicting comments in relation to how long these examinations last (1 session). I would appreciate a comment.
Man of 58 years-old with trauma (D12 vertebral fracture, fractured left shoulder blade, multiple rib fractures on the left). The scapular fracture treated with immobilization for 30 days (orthopedic). The patient has undergone neurosurgery of reduction / stabilization of the fracture with screws transpedicular D12 D11-D12 L1e kyphoplasty (duration surgery - 1 hour and 25 minutes, anesthesia duration - 2 hours and 15 minutes). The patient was placed in the prone position with the head resting on blankets and turned to the left. Immediately after the operation, during arousal, the patient experienced pain in the left eye, edema and amaurosis. He underwent angiography which showed signs of retinopathy in both eyes and a central retinal artery occlusion in the left eye (CRAO).The patient is diabetic with insulin pump therapy, hyperlipidemic (rosuvastatina), hypertension, occasional smoker or former smoker, hyperhomocysteinemia, assumes Cardioaspirin. The doppler has revealed a thickening of the left carotid artery with a fibro-calcific plaque without significant impairment of flow. In addition, both the CT that the brain MRI showed multiple small areas of gliosis of the white matter, as from vascular cerebral disease. According to your experience, could the prone position to have been the only cause of ocular damage?
Do you have any bioplex beads for bradykinin and eotaxin for measurement in allergic eye disease?
A 24 year old healthy male presents with a staph cellulitis, no purulence. 2 days after he presents with a furuncle on other knee. 2 days later he presents with a sty looking lesion on L eyelid. Eyelid lesion develops as a staph abcess related to a hair follicle and suppurating abundantly every morning, affecting soft tissue of orbital socket.
Interested in the mecanism of eyelid infection.
Interested in how common could and eyelid furunclle of this type be.
I'm doing a study on an eye disease and am collecting tears for cytokine analysis. I would like to collect reflex tears from patient participants, but it has been very difficult to do so. I tried generating the sneeze reflex by tickling the nose with a sterile cotton bud, but it didn't work. Then I tried onion vapours, but that didn't work either. Does anyone have ANY suggestions on how I could do this? If onion vapours/cotton-bud worked for you, would it be possible for you to let me know what protocol/procedure you followed?
Any advice would be much appreciated. Thanks.
I'm a PhD student and I'm doing a work to develop a business model. I also want to know if anyone can tell me where I can find the costs of pre-clinical an clinical trails for eye disorders.
I want to use a contact lens for rabbit for transplantation of stem cells to the corneal surface with substrate. i want to put a contact lens which can also able to diffuse gas (oxygen and CO2). I want to use this lens just to avoid the problems due to blinking. Please suggest me from where I can get this. Please also suggest me, what other methods would be possible. As I am also not able to suture the cell-substrate sheet. I also would like to get information about other ways to put the cell-substrate patch over the cornea other than chemically defined bioadhesive. Please do help in this. Thanks!!!
Is there a difference between automated refraction and manual refraction after cycloplegia in children?
I am working on calcium signaling in retinal microglial cell and its physiological function. I want to know how the calcium signaling travels in retinal microglial cell and how the calcium signal play role in diabetic retinopathy?
the latest anti-VEGF drug for retinal vein occlusion, age-related macular degeneration, macular edema is Aflibercept. It is important to examine drug-related systemic side effects (stroke, tromboembolic events,etc.) in therapy by Aflibercept (EYELEA)
I am looking for a company which is interested in developing and producing special eye glasses that help patients with strabismus. Of course we are talking about companies interested in research at this moment.
Computer vision syndrome (CVS) is a temporary condition resulting from focusing the eyes on a computer display for protracted, uninterrupted periods of time. Some symptoms of CVS include headaches, blurred vision, neck pain, redness in the eyes, fatigue, eye strain, dry eyes, irritated eyes, double vision, vertigo/dizziness, polyopia, and difficulty refocusing the eyes. These symptoms can be further aggravated by improper lighting conditions (i.e. glare or bright overhead lighting) or air moving past the eyes (e.g. overhead vents, direct air from a fan). [Source: Wikipedia]
With the increasing access to digital devices, Computer Vision Syndrome is becoming a common ailment
Nowadays ours eyes do not get adequate rest as most of the time we are either on our computer, laptop, i-pad, mobile or watching television. Eye strain caused by excessive use of computer is called Computer Vision Syndrome or digital vision syndrome. It manifests as tiredness, inability to work for long hours, blurring of vision, double vision, watering, redness, itching and pain in eyes. These symptoms will be present in 95 per cent of people who use the computer for more than three hours a day.[Source: The Hindu]
Some Excerpts from the second article:
What To Do
Posture and Exercises
Good posture and regular exercises of back and cervical muscles are a must if you use the computer for more than three to four hours a day.
The room should be well illuminated with the light source positioned in a way that light does not fall directly on your eyes or on the screen The light source should be behind the screen or on the ceiling and partially covered. anti-glare screens and spectacles can also help.
Normally we blink 10 to 12 times a minute. When we watch TV our blink rate is 5 to 6 a minute and while working on the computer it further goes down to 3 to 4 times a minute. Reduced blinking causes evaporation of tears thereby increasing the osmolarity (concentration) of the tears. The hyperosmolar tears induce inflammation and tear film instability which in turn cause increase reflex lacrimation. In other words, the dry eye caused by Computer Vision Syndrome may present not only as dry eye but may present as watering and inflamed eye.
To overcome this, it is better to have the computer screen 20 to 40 degrees below the eye level. This causes partial closure of the eyes by the lids thereby decreasing the evaporative surface.
Your comments and views are welcome. Muchas Gracias !!
A resident of Ophthalmology complains from both eyes floater, left eye floater is visible every time and right eye only when looks to white board for more than 3 years, flashing is observable in left eye only once or twice a week. He has just known about this problem when he studied about and states that his left eye had this problem since childhood. Please give your idea about the risk of RRD and that he will be an ophthalmologist in the future he is worrying about his profession.
What is your experience with amphotericin b injections in anterior chamber, how often do you inject and how long? What you do if doesn`t help?
Since vitrectomy is already done is there a role for re-vitrectomy?
Firm eye padding is frequently recommended as the initial management for moderate hypotony and shallow anterior chamber in the first few days post trabeculectomy. This might result from excessive filtration or a small leak.
Just wondering if there is any evidence out there in support of this, especially the bio mechanics of it. Putting pressure on a hypotonous eye might lead to some increase in the IOP, thereby forcing aqueous out and aggravating the shallow AC.
Would very much appreciate other views on this.
In ocular infections, especially in infectious keratitis, microbiological analysis is difficult due to the small amount of material / probe.
What is the best method: directly inoculate the swab or use a transport medium as in eSwab an let the lab do the inoculation?
How to store the swab / the agar plate? What plates to use? Are there any time or temperature limits or implications? What swab system can you recommend?
Can you recommend any references on the topic?
The standard textbooks define wet AMD as a neovascular disease. The poor response of wet AMD towards macugen therapy (anti-VEGF against VEGF A 165, a selective antivascular form of VEGF) arises the question whether wet AMD is predominantely a neovascular disease or more than that an exsudative disease. What do you think?
Recently Ahn et al. (Cornea 2013; 32:971-975) published promising results on the photocoagulation (514 nm) of pinguecula. Has anybody else experience with this method?
It is mentioned that larger Vertical CDR a risk factor for glaucoma. It is puzzling: why would a larger vertical CDR be a risk factor and not the larger horizontal CDR?
Can it be possible that enlarged vertical CDR represents cases in which glaucoma has already been initiated and the cup has enlarged vertically after the development of notches in the superior and inferior poles of disc?
Left eye: cataract operation done, vhigher IOP, vall medicaments used, diode laser done, no benefit.
AGV implanted, followed by band & bullous keratopathy. Now there is vision, but feeling only light, null.
We were advised that nothing was to be done.
Right eye: cataract began, IOP elevated.
I read studies that have reported changes in visual outcome just 3 months post-KC surgery. I am looking for any explanation as to why these studies did not wait at least a year before reporting their findings.
Myopia is common among the students or persons particularly females who have a height less than 5 feet. Mostly its incidence is directly proportional with the shortness of height. We observed that it is less common among the taller students particularity in males who are generally taller than the females.
In most of these patients myopia gradually increase from --1 to --3, and even more within few years after starting to use concave lens.
Causes of this myopia and its deterioration may be due to at least two factors:
1. Students commonly use reading desk with same standard height in the school and at home. Students with short stature have to focus their eyes at a closer distance than taller students. To compensate this closer vision, optical power of the eyes begins to increase during early teenage period and these students become myopic.
2. During correction of myopia ophthalmologists prescribe negative lens usually for constant use. Although these concave lens are not needed for near vision, but due to constant use of the lens according to the physician’s advice, the optical power of the eyes increase gradually to compensate the concave lens and the student increasingly become more myopic. This is a vicious cycle. In this way myopia continues to increase at least during their studentship period. So use of reading desk at school and home with appropriate height of the students should prevent myopia and avoidance of concave lens used for distant vision or use of appropriate lens during closer vision will prevent further deterioration of the affected students or people.
A patient sees 6/9 in each eye and complains of seeing haloes and dry-eye-type symptoms. He has a minor degree of lens opacity and the microcystic corneal dystrophy. How would colleagues manage this patient? Would they proceed to cataract surgery in the first instance?
Although KC is defined as a non-inflammatory condition it has long been my view that inflammation must play a role in the condition. KC progression is associated with allergy, vigorous eye rubbing, and even contact lens wear. We know that all of these situations can cause inflammation so my question is why has the role of this inflammatory process not been further investigated in the pathogenesis of KC? In our practice we aggressively treat the allergy (and rubbing) associated with KC in an attempt to prevent further progression. So far our results have been good with documented changes in corneal topography and Pentacam scans (although not reported in the literature). Your views on this issue will be appreciated.
I am looking for examples for acquired visual dysfunctions with regards to accidents and/or diseases. Are these dysfunctions stable, declining, or improving? Do they include blindness or what kind of visual capacity?
Thanks in advance!
Patient aged 71, compensated diabetes, worked and got infected in Iraq after a severe pneumonia. Bacteriology revealed Klebsiella, E. coli and S. aureus.
Glaucoma is a disease marked by the progressive death of RGCs and often accompanied by increases in IOP and abnormalities involving the ciliary system. But what is the anatomical connection between the two bodies?