Estrogen Receptor - Science topic

The exploration of deep learning techniques for predicting various biological characteristics of endometrial cancer (EC) is of significant importance. The objective of this study was to develop an optimized radiomics scheme combining multiparametric magnetic resonance imaging (MRI), deep learning, and machine learning to predict biological features...

Breast cancer remains the most common cancer among women globally, with significant morbidity and mortality. Current treatment for breast cancer, both in the early stage and metastatic setting, is based on a tumour biopsy and immunohistochemical detection of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HE...

Alpha-Mangostin, a natural xanthone from Garcinia mangostana, and its structurally optimized derivatives were evaluated as anticancer agents targeting estrogen receptor proteins linked to breast cancer: Estrogen Receptor Alpha(3ERT), Estrogen Receptor Bound to Estradiol(1ERE), and Estrogen Alpha Ligand-Binding Domain Complex(1A52). Alpha-Mangostin...

The detection of Fe(III) ions and monitoring of pH conditions are vital for safety, efficiency, and sustainability in scientific research, environmental management, and industrial applications. In this study, two 1,2‐biphenyl‐substituted benzimidazole‐1,2,3‐triazole hybrids, Pact and Oact, were designed, developed, and characterized by various spec...

Purpose Estrogen receptor (ER)-positive breast cancer is the most common subtype, accounting for approximately 80% of cases, with endocrine therapy as the standard postoperative treatment. However, despite risk-reducing therapies, the risk of recurrence remains substantial. Studies, including the POETIC trial, have demonstrated that low Ki67 levels...

SwissDock is a web-based molecular docking server that has been launched with the new Attracting Cavities 2.0 (AC 2.0) algorithm which incorporates the CHARMM forcefield and the fast analytical continuum treatment of solvation (FACTS) model. It demonstrated a significant impact on the docking process. With its user-friendly graphic interface and li...

Uterine stromal tumors encompass a histologically and clinically heterogeneous group of neoplasms ranging from benign endometrial stromal nodules (ESN) to low-grade and high-grade endometrial stromal sarcomas (LG-ESS and HG-ESS). Reliable markers for diagnostic stratification and prognostic assessment remain limited.This study aimed to evaluate the...

Background: The estrogen receptor (ER) and GATA-binding factor 3 (GATA3) are implicated in the pathogenesis and progression of various cancers, including bladder cancer. Although the relationship between GATA3 and ER in bladder cancer remains underexplored, these markers have shown promise in other neoplasms such as breast cancer. This study invest...

Background Homologous recombination deficiency (HRD) affects breast cancer patients. Treatment guided by multigene testing may be particularly beneficial in HRD patients by using platinum-based drugs and poly ADP-ribose polymerase inhibitor (PARPi). However, the optimal method for HRD testing remains undetermined by guidelines or consensus and econ...

Background The optimal duration of extended endocrine therapy (ET) for women with hormone receptor-positive (HR-positive) early-stage postmenopausal breast cancer remains uncertain. This meta-analysis systematically evaluated the optimal time to prolong aromatase inhibitors ( AIs) therapy for postmenopausal early stage breast cancer who received in...

Cholesterol is involved in the regulation of various signaling processes, and oxysterols are essential lipid messengers. The cholesterol derivative 25-hydroxycholesterol (25-HC) is overproduced by muscle macrophages in sarcopenia, myasthenia, and neurodegenerative diseases. Herein, we examined the effects of 25-HC on Ca²⁺ signaling and contractions...

Background Preeclampsia is a hypertensive disorder of pregnancy that affects multiple organs, including the heart, increasing long-term cardiovascular risks for both the mother and offspring. While the G protein-coupled estrogen receptor (GPER) has cardioprotective effects, its role in pregnancy-associated cardiac dysfunction, particularly in chron...

Background Integrin subunit Alpha 3 is essential for cell adhesion and movement, but its role in breast cancer (BC) is unclear. This study evaluated ITGA3 expression in BC and its clinical significance. Methods The Human Protein Atlas (HPA), UALCAN, and Kaplan–Meier plotter were used to analyze ITGA3 in BC. ITGA3 was evaluated using receiver opera...

The relationship between preeclampsia and breast cancer risk is still debated, with observational studies yielding inconsistent results. This research aims to clarify the causal link between preeclampsia and breast cancer using Mendelian randomization (MR) methods. We utilized genome-wide association study (GWAS) data to identify single nucleotide...

Introduction: Breast cancer is the most common cancer among females, accounting for 18.5% of cases globally. It is a heterogeneous disease with varying clinical, pathological, and molecular features. Molecular classification into Luminal A, Luminal B, HER2-enriched, and Triple-Negative subtypes, based on immunohistochemical markers (ER, PR, HER2, K...

Breast cancer (BC) is a heterogeneous disease with subtypes based on receptor status (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor 2 [HER2]), influencing prognosis and treatment. A higher socioeconomic position (SEP) is associated with an increased BC risk, but its relation to BC subtypes is less cl...

Opinion Statement Endocrine therapy is the backbone of treatment for HR + /HER2- MBC. The introduction of novel endocrine-based therapies has changed the landscape of metastatic breast cancer care, with even more promising agents on the horizon. Given the consistent success in prolonging PFS and OS, CDK4/6 inhibitors should be used as first-line tr...

Breast cancer is one of the most commonly diagnosed forms of the disease, and it is also the leading cause of cancer-related deaths among women worldwide. One of the most important contributors to the development of breast cancer in women is the presence of hormones dependent on estrogen. As a result, there is an urgent need for drugs that are more...

Background: Breast cancer remains the most prevalent cancer in Indian women. The histopathological examination by morphology, accompanied by the recommendation to assess hormone receptors—specifically Estrogen Receptor (ER), Progesterone Receptor (PR), and HER2—by the College of American Pathologists and the American Society of Clinical Oncology, a...

Background: Breast cancer is a leading cause of cancer-related morbidity and mortality worldwide. Advances in early diagnosis and molecular profiling have significantly improved treatment outcomes. The triple marker test, which assesses estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status, p...

Background Breast cancer (BCa) is the leading cause of cancer-related death among women worldwide. MicroRNAs (miRNAs) are promising tools for diagnosis and prognosis. This study investigated the role of serum miRNAs and tumor markers (TMs) in the diagnosis of BCa. Methods Differentially expressed miRNAs were screened from serum samples of BCa pati...

Age–period–cohort (APC) model outputs have been used extensively to produce forecasts of cancer incidence, identify emerging public health concerns, and quantify the impact of potential interventions. However, these models have not been extended to forecast cancer prevalence—the number of cancer survivors per capita. Recent advancements in cancer s...

Purpose The CPS + EG score, widely used for risk assessment in high-risk HR + /HER2-early breast cancer following neoadjuvant chemotherapy (NAC), integrates clinical and pathological staging, estrogen receptor status, and nuclear grading (nG). However, histological grading (hG) is often used in clinical practice due to better availability. This stu...

Background This study aims to investigate the factors associated with breast cancer brain metastasis (BCBM) in individuals suffering from breast cancer (BC). Materials and Methods This cross-sectional study conducted on 200 patients with metastatic breast cancer (MBC) including 52 brain and 148 other organ metastases. The demographic, medical, cli...

Purpose Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide, with significant differences in incidence and outcomes between men and women. Estrogen receptor alpha (ERα) expression is associated with sex-based differences and poor prognostic outcomes in HCC. However, the detailed function of ERα in the tumor microenvironment o...

Breast cancer is one of the leading reasons of mortality due to cancer globally. Estrogen receptor-positive (ER +) breast cancer being a significant subtype. The therapeutic potential of Vitamin D3 in cancer treatment has gained attention due to its ability to modulate key molecular targets and signaling pathways. This study investigates the antica...

Background/Objectives: Breast cancer is the most prevalent cancer in adult women. Currently, new therapies and protein determinations with prognostic value are under development. Fascin (encoded by the FSCN1 gene) is an actin-binding protein that is critical for the development of cytoplasmic projections that are essential for tumor invasion. DNA t...

Background Visceral adipose tissue (VAT) is strongly associated with metabolic diseases. Both high-intensity interval training (HIT) and moderate-intensity training (MIT) reduce VAT effectively; however, HIT might mediate greater VAT loss in females. The estrogen receptor α (ERα) pathway may play a key role. The aim of the present study was to conf...

Breast cancer (BC) is a multifactorial condition and it primarily expresses the estrogen receptor α (ERα) that is encoded by the gene estrogen receptor 1 (ESR1), which modulates estrogen signaling. ESR1, by facilitating estrogen overproduction, plays an indispensable role in the progression and survival of the majority of BCs. To obtain molecular i...

Breast cancer remains one of the most prevalent malignancies worldwide, necessitating the search for novel therapeutic agents. Melochia corchorifolia, a medicinal plant known for its diverse bioactive compounds, has gained attention for its potential anticancer properties. This study aims to evaluate the phytochemical composition of Melochia corcho...

Objective Seventy percent of newly diagnosed breast cancers are estrogen receptor-α positive and HER2/neu negative. First-line treatments incorporate endocrine therapy and cyclin-dependent kinase 4/6 inhibitors. However, therapy resistance occurs in most patients. Hence, there is an urgent need for effective second-line treatments. We previously sh...

It is increasingly recognized that severe acute traumatic events (e.g., mass shooting, natural disasters) can provoke enduring memory disturbances, and these problems are more common in women. We probed the fundamental sex differences underlying memory vulnerability to acute traumatic stress (ATS), focusing on the role of the sex hormone, estrogen...

Endometriosis is characterized by alterations of the action and control mechanisms that lead to the development of ectopic endometrial tissue. This study aimed to analyze the molecular profile of ectopic endometrium by evaluating the expression of several biomarkers [estrogen receptor (ER), progesterone receptor (PR), anti-apoptotic protein Bcl-2,...

Background: Fibroblast growth factor (FGF) signaling plays a crucial role in several cellular functions in cancer cells. Tasurgratinib, formerly known as E7090, is an orally available FGF receptor (FGFR)1–3 selective inhibitor. Here, we present the effects of tasurgratinib on the resistance to CDK4/6 inhibitors and endocrine therapy (ET) in a precl...

Introduction: Breast cancer is a heterogeneous disease with variable molecular profiles. This study aims to evaluate the expression of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), phosphatidylinositol-4,5- bisphosphate 3-kinase catalytic subunit alpha (PIK3CA), interleukin-8 (IL-8), and antige...

Pseudomonas aeruginosa (PA) causes severe respiratory infections utilizing multiple virulence functions. Our previous findings on PA quorum sensing (QS)-regulated small molecule, 2'-aminoacetophenone (2-AA), secreted by the bacteria in infected tissues, revealed its effect on immune and metabolic functions favouring a long-term presence of PA in th...

This review explores the potential role of androgens in human breast cancer and female canine mammary tumors. Human breast cancer is one of the most common cancers affecting women globally, while female canine mammary tumors provide a natural model for the study of human breast cancer due to their similar histopathologies and molecular features. An...

Introduction. Gastric cancer maintains a significant position among malignant neoplasms in terms of incidence rates and cancer-specific mortality, with a higher prevalence in geriatric patients. In recent years, there has been a notable trend of increasing oncological morbidity in younger individuals. The aim of the study is to identify the epidemi...

Background Breast cancer (BC) is the most prevalent cancer among women worldwide, with increasing incidence rates, particularly in China. Given the high costs of Oncotype DX (ODX) testing, which predicts recurrence scores (RSs) on the basis of gene expression, developing a nomogram utilizing clinicopathological variables may provide an accessible a...

Background Cyanotic congenital heart disease (CHD) in children has been associated with neurodevelopmental abnormalities, although the underlying mechanisms remain largely unknown. Multiple factors are likely involved in this process. This research aims to explore the potential effects of hypoxia and vascular system-derived factors in neurodevelopm...

Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer with the worst outcome, is not amenable for known target therapies, and has a poor response to chemotherapy. Androgen receptor (AR) was evaluated as a predictive, prognostic, and therapeutic factor in TNBC, but with contradicting results and the cutoff used for positiv...

Background: The human body is highly dependent on adequate oxygenation of the cellular space for physiologic homeostasis mediation. The insufficient oxygenation of the cellular space leads to hypoxia. Hypobaric hypoxia (HH) is the reduction in oxygen partial pressure and atmospheric pressure during ascent to high altitudes. This state induces a ma...

Background Recent trials have integrated immune checkpoint inhibitors (ICIs) into neoadjuvant chemotherapy (NAC) in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer of histologic grade (HG) III. We assessed the pathological complete response (pCR) rate according to the level of st...

Background: A unique subtype of breast cancer called triple-negative breast cancer (TNBC) is distinguished by the lack of expression of the HER2 (human epidermal growth factor receptor 2), PR (progesterone receptor), along with ER (estrogen receptor). In comparison with other subtypes of breast cancer, TNBC has been linked to a worse prognosis and...

Background Our goal was to evaluate the impact of level of androgen receptor (AR) expression on outcomes in women with estrogen receptor α (ER) positive breast cancer. We sought to corroborate our preclinical findings that AR-agonists were efficacious in patients with ER-positive tumors that also expressed high levels of AR. Methods Tissue microar...

Adenomyoepithelioma of the breast (AME) is a rare, biphasic tumor characterized by the coexistence of both epithelial and myoepithelial cell components, which can present as benign, atypical, or malignant forms. We present a 50-year-old female diagnosed with malignant AME (M-AME) exhibiting low-positive estrogen receptor (ER) expression of 5%, alon...

Bisdemethoxycurcumin (BDMC) is a naturally occurring compound having anti-cancer properties. We investigated the effect of BDMC on DMBA-induced mammary toxicity in female Wistar rats. Forty-eight virgin female rats were divided into six groups at random. Group 1 received corn oil, group 2 received DMBA (50 mg/kg), groups 3 and 4 received DMBA and B...

Purpose Endocrine therapy resistance is the major challenge of managing patients with estrogen receptor positive (ER+) breast cancer. We previously reported frequent overexpression of FGFR4 in endocrine-resistant cell lines and breast cancers that recurred and metastasized following endocrine therapy, suggesting FGFR4 as a potential driver of endoc...

In previous studies, we discovered YZD-7082B, a selective estrogen receptor degrader (SERD) with excellent comprehensive properties. Here, we reported the development of an efficient multigram-scale synthetic process for YZD-7082 in 13 steps. The route featured a chiral resolution of a thiochroman intermediate with a unique cis-1,2-diaryl motif usi...

Background HER2 expression has a central role in breast cancer carcinogenesis and is associated with poor prognosis. Lately, identification of HER2-low breast cancer has been proposed to select patients for novel HER2-directed chemotherapy and includes cancers with immunohistochemistry (IHC) 1+or 2+with negative fluorescence in situ hybridization (...

Objective To investigate associations between breast cancer molecular subtype and intravoxel incoherent motion imaging (IVIM) and amide proton transfer-weighted (APTw). Methods This prospective study involved 264 patients with suspected breast tumors who underwent both breast APTw and IVIM MRI. The maximum diameter of the tumor (Dmax), APT value,...

Males suffer more often from profibrotic changes in liver than females. The underlying mechanism for this sex difference in the prevalence and manifestation of Metabolic dysfunction-associated Steatotic Liver Disease (MASLD) is not yet completely known. We studied male and female mice that were induced to develop MASLD by consuming a “fast food” di...

Let-7 microRNAs are tumor suppressor microRNAs, and their reduced expression frequently occurs in various types of cancers, including breast cancer. A notable correlation exists between decreased let-7 microRNA levels and the overexpression of Lin28A and Lin28B, particularly in breast cancer cases with poor prognoses. Dysregulation of Wnt signaling...

Osteoarthritis (OA) is a progressive degenerative joint disease that significantly impairs mobility and quality of life, particularly in aging populations. Current therapeutic approaches primarily focus on symptom relief, but fail to address the underlying mechanisms of cartilage degeneration. In recent years, epigenetic reprogramming has emerged a...

Background: Adenomyosis and endometriosis are estrogen-dependent disorders characterized by ectopic endometrial proliferation. While traditionally considered benign, atypical endometriosis exhibits histological and molecular features associated with neoplastic transformation, particularly in the development of endometriosis-associated carcinoma. Th...

Introduction: Hormone receptor-positive (HR+), HER2-negative metastatic breast cancer (mBC) remains a prevalent and challenging disease. Endocrine therapy (ET) combined with CDK4/6 inhibitors is the first-line standard of care, yet resistance mechanisms, including ESR1 mutations, drive disease progression. Novel oral selective estrogen receptor de...

Background Sentinel lymph node biopsy (SLNB), a standard surgical procedure for clinically axillary-negative breast cancer patients, significantly reduces complications compared with axillary lymph node dissection, but it is still a relatively invasive procedure with some complications, affecting patient’s quality of life. To identify patients who...

The class of endocrine-disrupting pollutants within the realm of emerging contaminants has been increasingly subjected to intense scrutiny as a result of their presumed potential to imperil human health. Nevertheless, the interaction of triphenyl phosphate (TPP), a flame retardant, with endocrine nuclear receptors has received relatively less resea...

Objective Male breast cancer (MBC) is a rare malignancy, representing less than 1% of all breast cancer cases. Despite the rising incidence, MBC research remains limited, with most data extrapolated from female breast cancer (FBC). This study evaluated the clinicopathological features, treatment strategies, and survival outcomes of MBC patients in...

ABSTRACT Aim: To study the impact of the estrogen receptor beta polymorphisms rs4986938 (AluI) and rs1256049 (RsaI) on ischemic heart disease as well as the atherogenic index in Iraqi population. Materials and Methods: A case-control research study was conducted on a sample of Coronary artery disease patients in addition to a group of normal indivi...

Sex steroids and the neurotrophin brain-derived neurotrophic factor (BDNF) participate in neural tissue formation, phenotypic differentiation, and neuroplasticity. These processes are essential for the health and maintenance of the central nervous system. Aim: The aim of our review is to elucidate the interaction mechanisms between BDNF and sex ste...

Background Recently, the US Food and Drug Administration approved a new oral selective estrogen receptor downregulator for breast cancer, namely, elacestrant (Orserdu). This study aimed to analyze the signals of adverse events (AEs) within the introduction of elacestrant to the market using the FDA Adverse Event Reporting System (FAERS) database....

Genotoxic estrogen metabolites generate various DNA lesions; however, their target genes and carcinogenic mechanisms remain unexplored. Here, genome-wide sequencing using click probe enrichment coupled with liquid chromatography-tandem mass spectrometry (Click-Probe-Seq/LC-MS²) is developed to identify damaged genes and characterize the released an...

Objective: Axillary Reverse Mapping (ARM) aims to preserve arm lymph nodes to prevent breast cancer-related lymphedema (BCRL). This study evaluates the oncological safety of ARM by assessing metastasis rates while preserving arm lymph nodes. Material and Methods: Twenty-five breast cancer patients undergoing Axillary Lymph Node Dissection (ALND) wi...

Breast cancer stem cells are a promising therapeutic target in cancer. We explored breast cancer stem cell diversity and establish a methodology for selectively culturing breast cancer stem cells. We collected breast cancer tissues from surgical samples of treatment-naïve patients with estrogen receptor (ER)-positive, human epidermal growth factor...

Background: The discovery of novel antibody–drug conjugates for low-expression human epidermal growth factor receptor 2 (HER2-low) breast cancer highlights the inadequacy of the conventional binary classification of HER2 status as either negative or positive. Identification of HER2-low breast cancer is crucial for selecting patients who may benefit...

Increasing evidence implicates prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP), a common endocrine-disrupting plastic chemical, in autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD). However, the underlying mechanisms are poorly understood. Here we examined whether cord blood DNA methylation, a key epigenetic...

Cutaneous melanoma (CM) is the most aggressive and fatal malignancy among other skin cancers and its incidence has risen steadily recently around the world. Hormone-related therapy, particularly estrogen (E2) has been used as a prospective strategy for CM treatment. Quercetin and luteolin are flavonoids with antitumor effects against a wide range o...

Background: Estradiol (E2) has a significant impact on the development and progression of breast cancer via oxidative metabolism. It regulates cell proliferation and death in breast tissue by interacting with the Estrogen Receptor (ER). The CYP17 gene, which is essential for estrogen metabolism, has been linked to an increased risk of breast cancer...

Estrogen receptor (ER) α is a key regulator of osteoclasts in osteoporosis induced by estrogen deficiency. Although ERα is regulated through interactions with various coactivators, the precise mechanisms remain unknown. We used LC-MS/MS to screen proteins that bind to ERα and identified a physical interaction between HSD17B7 and ERα, specifically t...

Triple-positive breast cancer (TPBC), a unique subtype of luminal breast cancer, is characterized by concurrent positivity for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Owing to the crosstalk between the ER and HER2 signaling pathways, the standard of care and drug resistance of this pa...

Estrogen receptor β (ERβ) is the most highly expressed subtype in the colon epithelium and mediates the protective effect of estrogen against the development of colon cancer. Indeed, the expression of this receptor is inversely related to colorectal cancer progression. Structurally estrogen-like compounds, including vitamin E components, affect cel...

To explore the hypothesis that differential exposures to estrogen active chemicals may contribute to regional disparities in cancer incidence, a comprehensive targeted and nontargeted analysis was conducted over two seasons (2020) for drinking water samples from 120 households served by 8 public water systems (4 with historically elevated breast ca...

Background Cytochrome P450 1B1 (CYP1B1) enzyme plays an important metabolic role, especially in the metabolism of xenobiotics, endogenous substances, and procarcinogens. It may be involved in tumor initiation and progression. High levels of CYP1B1 have been identified in aggressive breast cancer cell lineages. The aim of the present study was to id...

Immune evasion by cancer cells involves reshaping the tumor microenvironment (TME) via communication with non-malignant cells. However, resistance-promoting interactions during treatment remain lesser known. Here we examine the composition, communication, and phenotypes of tumor-associated cells in serial biopsies from stage II and III high-risk es...

Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer defined by the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression. Despite accounting for 15–20% of all breast cancer cases, TNBC is associated with poor prognosis and a high likelihood of recurrence and met...

Accumulated evidence suggests a tangible increase in breast cancer (BC) patients in the Kurdistan region of Iraq, yet data on their histological and molecular subtypes remain limited. This study aims to assess the prevalence, histopathologic features, and molecular profiles of BC incidences in Erbil. For this purpose, 261 clinical records of histol...

Background Evidence on breast cancer survival and factors affecting survival is crucial for evaluating treatment effectiveness and formulating breast cancer control strategies. Although original research has been conducted on the survival rate of breast cancer patients and their determinants in Ethiopia, there is a shortage of comprehensive scienti...