Erectile Dysfunction - Science topic

Tadalafil (TDL) is a drug clinically proven to treat erectile dysfunction, benign prostatic hyperplasia, and pulmonary hypertension. TDL is classified as a BCS Class II drug, which means it has high permeability but low solubility. Solubility enhancement is achieved through the inclusion complex method and verified by dissolution testing. This stud...

S1978 Clinical-Urology ESTRO 2025 difference in bPFS was observed between BRCA-positive and BRCA-negative patients (HR 0.93, p=0.06). However, BRCA-untested patients had a significantly lower risk of biochemical progression (HR 0.58, p=0.02). The addition of SBRT in the experimental arm showed a clear benefit in terms of bPFS in both the BRCA-negat...

Radiotherapy is indispensable for the successful treatment of many pelvic malignancies, but it is often associated with significant adverse effects on sexual function, including vaginal stenosis, decreased lubrication, erectile dysfunction, and loss of libido. Sexuality and sexual function are important aspects of quality of life for cancer survivo...

Introduction: Vasectomy is one of the most effective ways of contraception. However, it still has various complications, including post-vasectomy sexual dysfunction. Some studies suggest that one of the sexual performance problems can be linked to psychological factors. However, other studies indicate that vasectomy can have positive effects on pat...

Erectile dysfunction (ED) is a frequent complication following radical prostatectomy, significantly affecting patients' quality of life. Traditional predictive methods often struggle to capture complex nonlinear risk factors. This study aims to develop a machine learning-based model to improve ED risk stratification and guide personalized managemen...

The objective of this study was to investigate the chemical composition, biological activity, and intervention mechanism of Healthy Snow Lotus Wine in the treatment of erectile dysfunction (ED). A preliminary relative characterization and relative quantification of Healthy Snow Lotus Wine was conducted using ultra performance liquid chromatography‐...

Introduction: The use of inflatable penile prostheses (IPP) has become a well-established treatment for erectile dysfunction, offering significant improvements in the quality of life for many patients. The reservoir site and size in IPP surgery are areas of ongoing research and debate. This study aims to evaluate the outcomes associated with the us...

The increasing global demand for herbal aphrodisiac products has raised concerns regarding their safety and quality due to potential adulteration with synthetic or conventional pharmaceutical active ingredients. This study investigates the presence of sildenafil and tadalafil in selected herbal mixtures marketed for sexual enhancement available in...

Background Falsified medicines pose a severe threat to global healthcare, contributing to treatment failures, adverse health outcomes, and economic burdens. Aims This study aims to assess the awareness, detection capabilities, and reporting behaviors of pharmacists in Shymkent, Kazakhstan, regarding falsified medicines. Method A mixed-methods appro...

Although numerous Mendelian randomization studies on risk factors have been conducted in male medicine, a systematic synthesis of these findings is still lacking. This review searched relevant literature in PubMed and the Web of Science published before May 2024; systematically summarized the progress in the application of Mendelian randomization i...

Background Despite extensive literature on lumbar disc herniation and cauda equina syndrome, sexual dysfunction in these patients has been overlooked. We conducted a systematic review to gather scientific evidence on this issue following surgical treatment in this population. Methods On January 30, 2025, several databases, including PubMed, Web of...

A random-effects meta-analysis by Glantz et al. recently concluded that the odds of several diseases among current e-cigarette users and smokers were similar. This report details serious deficiencies. We used descriptive analysis methods to assess the studies the authors selected for cardiovascular disease (CVD), stroke and chronic obstructive pulm...

Background Treatment of patients with erectile dysfunction (ED) was revolutionized by the development and approval of phosphodiesterase type 5 inhibitors (PDE5is), which have been repeatedly shown to be safe and effective in men with this condition. However, some patients do not respond to these agents and others may prefer an alternative therapy....

The abundance of bioactive compounds present in garlic positions it as a promising agent in the support of human health. This paper constitutes a review of scientific literature published over the past five years, with sources identified through a search of the PubMed database. The review explores the effects of garlic on hypertension, lipid metabo...

Background Combination pharmacotherapy with tamsulosin plus tadalafil could be a superior strategy compared to conventional monotherapy with tamsulosin in patients with Benign prostatic obstruction (BPO) with or without erectile dysfunction. Methodology A comprehensive search was conducted across PubMed, the Cochrane Library, and Embase to identif...

Background Tunica albuginea plication is a common surgical treatment for Peyronie’s disease that aims to correct penile curvature and improve sexual function. The goal of this study was to evaluate patient-reported outcomes, complications, and predictors of success following plication surgery in a large cohort of patients. Results This retrospecti...

Background/Objectives: Erectile dysfunction (ED) is a prevalent condition worldwide that significantly affects men’s sexual health and overall quality of life. ED is often associated with both psychological and organic factors and may serve as an early indicator of underlying health conditions such as diabetes mellitus, hypertension, and cardiovasc...

This article discusses the development of spray medications as a novel and promising approach in therapy, focusing on their advantages, disadvantages, and potential applications. The main idea highlights the importance of innovative drug delivery systems, such as spray formulations, in modern medicine. The article reviews various studies and evalua...

Purpose Optimization of preoperative counselling and postoperative care pathways to maximize patient satisfaction and healthcare system efficiency requires an understanding of healthcare system interactions that result from postoperative patient concerns. We sought to identify patterns of healthcare utilization following inflatable penile prosthesi...

This study employs a comprehensive approach to systematically identify drugs associated with Drug-Induced Erectile Dysfunction (DIED) risk and constructs a DIED risk assessment platform. Utilizing the FAERS database, we identified “Erectile Dysfunction,” “Organic Erectile Dysfunction,” and “Psychogenic Erectile Dysfunction” as relevant Preferred Te...

Type 2 diabetes (T2D) is epidemiologically associated with a wide range of non-cardiovascular comorbidities, yet their shared etiology has not been fully elucidated. Leveraging eight non-overlapping mechanistic clusters of T2D genetic profiles, each representing distinct biological pathways, we investigate putative causal links between cluster-stra...

The fertility effects of antiseizure medications (ASMs) have been highlighted in females of reproductive age; however, the effects in males have not been extensively analyzed. This review aims to summarize the existing evidence of how ASMs affect sexual hormones and functions in males with epilepsy. We searched the Embase, PubMed, and MEDLINE datab...

Purpose To estimate the prevalence of Erectile dysfunction (ED) in a Hong Kong (HK) population, evaluate the understanding and perception of ED and compare results with the European Association of Urology (EAU) and The Urology Foundation Trust (TRTed-TUF) data. Methods A survey-based study was conducted between Dec 2023 and Mar 2024. The EAU and T...

Background Penile fracture (PF) is a urological emergency that can lead to significant complications if not treated promptly and understanding the factors influencing complications and outcomes in PFs is crucial for improving patient management. Aim This study aims to evaluate the impact of various factors on postoperative complications and outcom...

Background Male Sexual Dysfunction (MSD), comprising erectile dysfunction (ED), premature ejaculation, and hypoactive sexual desire disorder, exhibits an age-related prevalence affecting 50% of males beyond their fourth decade. Epidemiological studies demonstrate ED prevalence rates of 79.4% in general clinical populations. Beyond physiological man...

Peyronie’s disease (PD) is a connective tissue disorder characterized by abnormal collagen deposition in the tunica albuginea, leading to penile curvature, pain, and erectile dysfunction. This study aimed to evaluate the outcomes of a combined treatment protocol incorporating collagenase clostridium histolyticum (CCH), vacuum erection device, and t...

Benign Prostatic Hypertrophy (BPH) is the most common benign urological condition in males. It is a progressive condition associated with aging, affecting over 80% by age 80 and can affect quality of life. While the exact cause is not fully known, hormones, metabolic alterations, inflammation and vascular flow may be contributing causes of BPH. Med...

Plumbago zeylanica (PZ) root is a medicinal plant traditionally used to enhance erectile function, though its biochemical effects remain underexplored. This study investigated the modulatory effects of ethanol extract of Plumbago zeylanica root on markers of erectile and cardiovascular function in male Wistar rats. Thirty out of thirty-six rats wer...

Studies have examined the ameliorative effect of Tridax procumbens leaf (TPL) on erectile dysfunction of several etiologies. However, the role of TPL on crude oil-contaminated water source-induced (CW) erectile dysfunction and the role of phosphodiesterase 5 have not been investigated. This study explores the effect of TPL treatment on CW-induced c...

OBJECTIVES: Penile strangulation by penile constriction devices presents uncommonly but requires urgent intervention to minimize risk of developing erectile dysfunction and penile gangrene. Non-invasive methods with use of cutting tools have been attempted successfully. However, these cutting tools are fraught with problems of availability, technic...

Purpose The aim of this study was to evaluate the relationship between Fatty Liver Index(FLI) and Erectile Dysfunction(ED) and its severity. Materials And Methods A group of 230 male patients with ED complaints underwent evaluation. Comprehensive routine blood serum tests were conducted to identify potential etiological factors contributing to ED....

Purpose Indonesia's national health system recognizes the interconnectedness of Type-2 diabetes mellitus (T2DM), erectile dysfunction (ED), and cardiovascular consequences; thus, it incorporates ED screening as a recommended practice within its national guidelines for T2DM management. However, a notable gap persists concerning the interpretation an...

Historically, feminist discourses around pornography have focused on its uncritical replication of misogynistic tropes/attitudes. Ironically, discourse analysis suggests that these values are also rife in the male-dominated anti-pornography communities that academics are increasingly classifying as a constituent part of the manosphere. In these gro...

The study examined perceived health implications of erectile dysfunction among married men in Ibarapa North Local Government, Oyo State. The impact of erectile dysfunction could be devastating because evidence has shown that sexual function is one of the important indices of quality of life. Descriptive research design of the survey method was adop...

Sildenafil citrate, widely recognized under the brand name Viagra, has been a game changer in the management of erectile dysfunction (ED). While its therapeutic benefits in treating ED are well-established, its recreational use has led to significant psychological, behavioral, and social concerns. This article examines the unintended negative conse...

Background/Objectives: Urethral stricture disease, characterized by narrowing of the urethra due to scar tissue, affects urinary and sexual health. While urethroplasty is the standard treatment, its impact on erectile function is less understood. This study examines changes in International Index of Erectile Function (IIEF) scores post-urethroplast...

Erectile dysfunction (ED) is a common male sexual dysfunction and can be induced by diabetes mellitus (DM). Diabetes mellitus-induced erectile dysfunction (DMED) affects various aspects of the patient’s quality of life, mental well-being, and relationship dynamics. Given the increasing incidence of DM worldwide, the incidence of DMED is expected to...

Among the most common medical problems experienced by older adults (over 60 years) are diabetes, Parkinson's disease (PD), and erectile dysfunction (ED). The potential use of Mucuna pruriens in treating type 2 diabetes (T2D), PD, and ED is being investigated. Literature searches were conducted using the PubMed, MEDLINE, and Mendeley databases (1990...

Guided by implicit theories of relationships and sexual satisfaction and the theory of resilience and relational load (TRRL), our study investigated the mediating role of sexual communal strength on associations between implicit beliefs regarding sexual compatibility and relational thriving in new romantic couples (< 6 months duration) facing a hyp...

Introduction Urethroplasty is the gold standard for the management of urethral strictures. For obliterative bulbar strictures longer than 2 cm, excision primary anastomosis (EPA) cannot be optimally performed, and staged urethroplasty is recommended. To minimize multiple interventions, Augmented Anastomotic Urethroplasty (AAU) was developed. Our hy...

Background and objective It is important for patients to feel that they can address any topic during a consultation with a General Practitioner (GP), so that the care delivered is appropriate and relevant. This study aimed to investigate factors associated with unvoiced concerns of patients during a GP consultation, because of embarrassment, modest...

A retrospective analysis of 186 priapism cases between 2015–2024 was conducted using ICD-10 codes (N48.3) in a single high-volume institution. Data on age, race, insurance status, priapism subtype, etiology, and treatment outcomes were collected. The median age at presentation was 50.5 years (IQR: 39.3–60.0), with most patients being White (60.2%)....

Introduction Obesity has been linked to an elevated susceptibility to development of erectile dysfunction, yet the interplay between sex hormone levels, sexual function, and obesity remains unclear. This study aimed to investigate sexual dysfunction among male patients with obesity and to emphasize the importance of recognizing the problem and purs...

INTRODUCTION: The treatment of Peyronie's disease so far is not specific, however the literature shows different therapeutic options, one of which is physical therapy. Thus, based on the premise that physiotherapy can be a powerfull ally to conservative treatment in Peyronie's disease, it is necessary to carry out this systematic review, aiming to...

Background Erectile dysfunction (ED) is often not recognized in men with type 2 diabetes mellitus (T2DM), despite the prevalence of the disease. Early diagnosis of ED in T2DM is very important for effective treatment and prevention of serious complications such as cardiovascular events.This study investigates the prevalence and determinants of ED a...

This paper was an investigation into the perceived psychological and organic factors contributing to erectile dysfunction among male adults in Ogbomoso South Local Government Area. A sampled population of three hundred and twenty (320) constituted respondents for the study. A self-structured questionnaire that was validated by four experts in the f...

Premature ejaculation and erectile dysfunction are prevalent male sexual dysfunctions worldwide, causing significant distress for men and their partners. We investigated how physical activity was associated with self-reports of interoceptive awareness and autonomic regulation during sex as well as with premature ejaculation and erectile dysfunction...

Introduction and aim Prostate cancer (PCa) remains the most common non-cutaneous cancer among men in Europe, with treatment advances improving mortality outcomes. Radical prostatectomy (RP) is a key treatment option for localized PCa, anyway complications such as urinary incontinence and erectile dysfunction can influence patient satisfaction and d...

Background/Objectives: Relationship quality is closely tied to sexual health. This study compared the effects of tadalafil cream and oral tadalafil on Dyadic Adjustment Scale (DAS) subscales and assessed the influence of age on treatment outcomes. Methods: This study includes a secondary analysis of data collected during a previously published rand...

Low-intensity shockwave therapy (SWT) is a promising non-invasive treatment for vasculogenic erectile dysfunction (ED). Two primary modalities, focused linear shockwave therapy (fSWT) and radial shockwave therapy (rSWT), differ in energy delivery and tissue penetration. While fSWT is well-studied, rSWT remains less explored for ED despite its growi...

Background/Objectives: Erectile dysfunction (ED) significantly impacts the well-being and quality of life of millions of men. Understanding geographic patterns and associated factors influencing ED search trends can offer valuable insights for healthcare improvement and advocacy. This study investigated the correlation between Google search trends...

High-flow priapism (HFP) is a rare disorder that causes prolonged, painless erections. Because it has the potential to permanently damage erectile function, HFP should be promptly treated to regain potency. The suggested therapies for nonischemic priapism include surgical ligation of the arteriocavernous fistulae or selective arterial embolization....

OBJECTIVES : To compare long-term progression-free survival (PFS) and overall survival (OS) between patients undergoing robot-assisted radical prostatectomy (RARP) and open radical prostatectomy (ORP). MATERIALS AND METHODS: A cohort study was designed in the French nationwide claims database with a follow-up of 5 to 8 years. All men undergoing sur...

Traditional Chinese medicine prescriptions have a history spanning thousands of years and have retained profound cultural significance. These prescriptions represent the accumulated clinical medication experience of physicians across generations and serve as a vital tool for guiding clinical practice based on the traditional Chinese medicine theory...

Background: Erectile dysfunction (ED) is a prevalent complication among diabetic men, often refractory to conventional pharmacologic therapies due to vascular and neural impairments. Platelet lysate (PL), a growth factor-rich biological derivative, has emerged as a potential regenerative therapy for vasculogenic ED. However, data on its clinical ef...

Erectile dysfunction (ED) is a common complication of radical prostatectomy (RP), mostly due to cavernous nerve (CN) injury. Despite improved surgical techniques and tools, ED rates are still high. Electrophysiological studies help to understand the functional effects of RP on CN and cavernous smooth muscles. The aim of this study is to evaluate th...

The effects of erectile dysfunction (ED) and premature ejaculation (PE) on men’s mental health are well-studied, but their link to aggression has been less explored. Thus, we measured associations between ED, PE, and aggression of men in a large representative cohort with well-balanced demographic characteristics. Participants completed computer-as...

Background/Objectives: Femoral head avascular necrosis (FAN) is a serious orthopedic disorder that causes the death of bone tissue as the outcome of the occlusion or insufficiency of the vessels supplying blood to the femoral head. It is especially common in middle-aged men. Factors such as alcohol consumption, corticosteroid use, trauma, and syste...

Aktuální medicína 1 | 2025 39 E rektilní dysfunkce (ED) představuje častou sexuální poru-chu, definovanou jako trvalá nebo opakující se neschopnost dosáhnout erekce a/nebo udržet erekci dostatečnou k uspo-kojivé sexuální aktivitě [1]. U pacientů s diabetes mellitus (DM) se ED vyskytuje v mnohem vyšší míře než v běžné populaci, při-čemž prevalence j...

Introduction and aim: Erectile dysfunction has a significant impact on quality of life, substantially reducing both the mental and physical well-being of the affected men. This study examines the role of physical activity in the prevention and treatment of erectile dysfunction. Methods and materials: A comprehensive literature review was undertaken...

Background and Purpose Epidemiological studies suggest a relationship between vitamin D deficiency and erectile dysfunction (ED). We hypothesized that vitamin D deficiency or vitamin D receptor (VDR) knockout causes ED and analysed the underlying molecular mechanisms. Experimental Approach Erectile function was assessed in vivo in anaesthetized ma...

ANNOTATION. The information about the frequency and structure of complications in patients with hard erectile dysfunction, who have undergone the surgical treatment — penile prosthesis implantation, was analized. Received data prove that the variety of factors, that lead to irreversible damage of cavernous tissue, and a large number of forms of con...

Background: Spinal cord injury (SCI) is a life-altering event that is usually associated with loss of motor and sensory function, as well as sexual impairment. Materials and Methodology: The study was conducted in Multi-disciplinary hospitals and tertiary care centers in and around Pune. The authors administered questionnaires via Google Forms to 1...

Background Methamphetamine usage has become more widespread, which is a global societal concern. Drug-related vulnerable behavior can be avoided with the help of drug use data. The incidence and characteristics of sexual dysfunction are not well understood among Saudi patients, despite the fact that it is widely prevalent among methamphetamine abus...

ANNOTATION. The article is devoted to the problem of diagnosis and treatment of chronic prostatitis, accompanied by erectile dysfunction. Modern methods of diagnostics and treatment of such patients are presented, as well the differences in the approaches to diagnosis and treatment given in the Guidelines of the European Association of Urology and...

Current FDA-approved treatments for androgenetic alopecia (AGA) are oral finasteride and topical minoxidil. Topical finasteride offers a potential alternative with similar efficacy and fewer systemic side effects. This study evaluated the effectiveness and safety of combining topical finasteride and minoxidil for male AGA. This 12-week randomized c...

Vajikaran, a classical Ayurvedic tradition aimed at increasing sexual vitality and potency, addresses present-day challenges related to sexual health and dysfunction. In today's era of lifestyle shifts, increased stress levels, and environmental impact, the significance of Vajikaran has garnered growing interest. Ayurvedic texts indicate the utiliz...

Background Prolactinomas are the most common type of pituitary adenomas, typically managed with dopamine agonists. However, some cases are refractory to standard therapies, posing significant clinical challenges. This case highlights the complexities of managing an aggressive macroprolactinoma resistant to conventional treatments and explores the u...

Erectile dysfunction (ED) is a prevalent medical problem affecting men globally, particularly those with co-morbidities such as cardiovascular disease, hypertension, dyslipidaemia and diabetes. This case series aimed to evaluate the effects of avanafil as a treatment option for patients with ED and other co-morbidities. Eight male patients from a f...

Introduction Traumatic pelvic injuries are potentially life-threatening and disabling injuries that often result from high-energy impact. It is well established in the orthopaedic literature that adult pelvic fractures can result in urologic injury, especially posterior urethral injury. Pelvic trauma and associated injuries in children are less cha...

Background Real-world data on Peyronie's disease remains limited. Objectives Describe the demographics, clinical characteristics, and therapeutic management of Peyronie's disease patients in the United States. Materials and methods A retrospective analysis was conducted using the PearlDiver Mariner database (2010–2022). Male adults with Peyronie'...

Background There are different degrees of erectile dysfunction in men after radical prostatectomy, and it takes a long time for their sexual satisfaction to improve. Before the recovery of sexual function, the patient’s sexual relationship experience may change, which may affect the patient’s family stability. Therefore, the present study aimed to...

Background: Tribulus terrestris L. Zygophyllaceae (TT) is a plant that has been claimed to increase testosterone levels and improve sexual function, particularly erectile dysfunction, with potential benefits for male sexual health. Purpose: This systematic review aimed to evaluate the effectiveness of TT supplementation in improving sexual function...

Background Management of pelvic fracture-related urethral injury (PFUI) in children remains debated due to various complications. Patients typically receive either primary realignment (PR) or suprapubic cystostomy with delayed urethroplasty (SCDU), but optimal outcomes are unclear. This study evaluates these two surgical techniques by reviewing 20...

Introduction Avanafil (AVA) is a very efficient phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction. However, it has limited bioavailability when taken orally and considerable first-pass metabolism. Enhancing its solubility and choosing an alternative delivery route may enhance its effectiveness and duration of action. Met...

Aims TPN171 is a novel phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction. This study aimed to assess the immediate impact of a single dose of TPN171 (10 mg) on semen quality in healthy male Chinese volunteers. Additionally, the study investigated the exposure of TPN171 in seminal plasma and observed the safety of TPN171 i...

Phosphodiesterase 5A (PDE5A) is an enzyme that specifically hydrolyzes cyclic guanosine monophosphate (cGMP), a key second messenger involved in smooth muscle relaxation, cardiovascular function, and neurotransmission. PDE5A is highly expressed in vascular smooth muscle cells, cardiac tissue, and the corpus cavernosum. Its inhibition has proven to...

Objective Simiao Biejia (SMBJ) granules, a traditional Chinese herbal remedy, have been used to treat erectile dysfunction caused by diabetes mellitus (DMED). However, the molecular mechanisms underlying SMBJ’s therapeutic effects remain unclear. This study aimed to investigate the effects and mechanisms of SMBJ in a rat model of DMED using network...

Background Erectile dysfunction (ED) is common among men with Diabetes mellitus (DM), with a negative impact on their sexual satisfaction. There is a paucity of data on this in our locality. Hence this study was to determine the quality of sexual life, its correlates and predictors among such men. Methodology One hundred diabetic men with ED as we...

Sexual therapy is a relatively new development in the treatment of erectile dysfunction and other sexual dysfunctions. During the 19th and 20th century different methods of treatment were used for management of impotence0F0 F 1. In cases of psychological („psychogenic“) impotence, the most used treatment during the first half of the 20th century wa...

Introduction A study was performed to determine the most common and most bothersome symptoms and clinical associations in young men (18–40 years) presenting with lower urinary tract symptoms (LUTS). Methods Cross-sectional study was conducted across 16 centers. Urinary symptoms, impact of bladder problems, bowel symptoms, erectile dysfunction, pre...

Background: Insufficient erection development or maintenance for sexual performance is known as erectile dysfunction (ED). Globally, the incidence and prevalence of ED are rising. Recent epidemiological research indicate that approximately 10% of males between the ages of 40 and 70 suffer from severe or total erectile dysfunction. Another quarter o...