Erectile Dysfunction - Science topic

Please also see the RG link below.

Have a look at the RG links below.

Obstructive sleep apnea (OSA) is associated with a higher risk of erectile dysfunction (ED).

Use of viagra does not cause the development of melanoma.

Please take a look at this useful RG link.

There is no any concrete scientific evidence to prove that 'Gentaplex' is effective in treatment of erectile dysfunction.

What is your outcome variable? is it dichotomous or continuous?

for binary outcomes use qui square and t test (if you have 2 groups only) for continuous regardless of distribution as far as you use randomization to assign patients to treatments.

See Friedman 2015 book on clinical trials. Mohammad Al Qadire

Please take a look at this useful PDF attachment.

What sort of sexual disturbance does the alpha blockers cause?

The retrograde ejaculation is a side effect that indicates that the drug gives its action. no other sexual side effect is noted or mentioned by the patients.

and we mentioned that to the patient, as a symptom of drug effect.

For the first question: perform subgroup analysis according to the treatment doses. Further, conduct metaregression.

For the second question: network meta-analysis could be conducted but at first perform traditional meta-analysis then network meta-analysis to compare between 3 PDE5 inhibitors.

This paper may guide you:

PMID: 20462773 DOI: 10.1016/j.jdiacomp.2010.03.003

corpus cavernous is also covered with tunica albuginea, u have to remove tunica albuginea to get proper relaxation if u do not remove tunica albuginea you will not get relaxation. Corpus spongiosum is not a relevant tissue to check out penile erection.  therefore you should not use corpus spongiosum

Thank you Jonathan

My mail is poczta@remigiuszkijak.pl

Although not fully analyzed, in my experience, the use of ESWT (Extracorporeal shockwave therapy ) cycles on penis , improves erection and response to PDE5 inhibitors.

Dear Soheir, 

Check these out: 

YES it may be this will be  a fine study

Most of patients going for penile Doppler respond well to a dose of 10 micrograms of PGE1 when suboptimal response was found, underlining vascular element was present 

normal responders revealed optimal response 

hormonal cause of erectile dysfunction is less than 1%,  the main symptoms with hormonal decrease is loss of libido testosterone is indicated in these cases. its use with PDE5i inhibitors can be used  as aphorizing. 

I think penile hemodynamics should be investigated to proceed for further investigations and management 

Tri-mix is used effectively and the risk of pain is deminished with the combination of the 3 meds. If pain does occur, then you can take out PGE1 and still use Phentolamine and Papaverine (Bi-mix). Using this for penile rehabilitation after a Robotic Prostatectomy is something to consider as well.

Dear Goran Arbanas

If you are interested, there is another 38 item comprehensive questionnaire called "Sexual Functioning Questionnaire" that covers sexual dysfunction involving both sexes, designed and published by Smith et al in 2002, and subsequently validated by other studies, including 2 of my publications. The original article title is "Sexual dysfunction in patients taking conventional antipsychotic medication" by Smith et al in 2002 in British Journal of Psychiatry. You can find the entire questionnaire in the free full text of this article (within a window in the article that you need to click ,for the questionnaire to open). All the best. 

Hey there. For sexual PERFORMANCE you need to evaluate behavior, I think there is no other way besides behavior, so you will need female rats. But you can work with penile erection test, and sexual behavior with ovariectmized female rats induced with hormones. You can also invert the rat cycle, and work at day (you can manipulated the rat's circadian cycle and don't need to work at night).

But you can also see whethere is it gonna work (take a look): http://medicine.osu.edu/neuroscience/documents/The_Rat_As_A_Model.pdf

I'll look for other articles that could help you, than i'll post here

Dear friends Aftab and Gwen

Thank you so much for the comments.

I do agree with Aftab. It´s really difficult. Wearing uniform, Gwen, it´s not the case. I think we should go deep in this field, in order to give them quality of life. . What we´re facing now it´s a struggle between patient and family who is taking care of a quadriplegic. Patient "has the right" to be involved in an erotic envirnoment.. However dad and mom are against what they call "prostitution..." "religious and cultural violation..." etc. I`m looking for the best way to get around.