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Article
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To improve the response rate of immune checkpoint inhibitors such as anti-PD-L1 antibody in immunosuppressive cancers like triple-negative breast cancer (TNBC), induction of immunogenic cell death (ICD) at tumor sites can increase the antigenicity and adjuvanticity to activate the immune microenvironment so that tumors become sensitive to the inter...
Preprint
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The centromere is the chromosome region where the microtubules attach during cell division. In contrast to monocentric chromosomes with one centromere location, holocentric species usually distribute hundreds of centromere units along the entire chromatid. We assembled the chromosome-scale reference genome and analyzed the holocentromere and (epi)g...
Article
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A gestão de suprimentos e sua logística constitui-se em área desafiadora nos serviços hospitalares. Toda a cadeia de gestão de Equipamentos de Proteção Individual (EPIs) foi impactada pela pandemia, que passou a requerer a manutenção da qualidade aliada ao controle de dispensação, e assim reduzir-se perdas e custos, para evitar-se o desabasteciment...
Article
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Background: Trophoblastic diseases are in general exclusive to women in their reproductive years. Gestational choriocarcinoma (GC) is a rare malignant tumor derived from the trophoblast of women in childbearing age. Our objective was to study the epidemiological and clinicopathologic aspects at the laboratories of pathological anatomy and cytology...
Article
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There is an urgent need to find novel treatments for combating multidrug-resistant bacteria. Multidrug efflux pumps that expel antibiotics out of cells are major contributors to this problem. Therefore, using efflux pump inhibitors (EPIs) is a promising strategy to increase antibiotic efficacy. However, there are no EPIs currently approved for clin...
Book
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A obra, a seguir, intitulada “conhecimentos contemporâneos ligados às ciências sociais aplicadas vol. 2”, publicada pela even 3, apresenta 11 (onze) artigos que abordam assuntos relacionados à administração contemporânea; os artigos apresentados neste volume abordam: Análise de vida econômica de equipamentos de uma corretora de seguros para previsõ...
Article
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Background: Genomic analysis indicated that the genomes of ascomycetes might carry dozens of biosynthetic gene clusters (BGCs), yet many clusters have remained enigmatic. The ascomycete genus Epicoccum, belonging to the family Didymellaceae, is ubiquitous that colonizes different types of substrates and is associated with phyllosphere or decaying...
Article
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Background and Aim of the Study: Antiplatelet drugs available on the market have multiple side effects and pose drug interactions, which actuated the researchers to consider better alternatives by using plant extracts. It is well known that medicinal plants possessing anti-inflammatory action usually have antiplatelet aggregation and anticoagul...
Article
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Climate change has a wide range of impacts on Pakistan’s water resources system, followed by increased magnitude, frequency and intensity of extreme events. Therefore, investigating the variations in extreme climatic events is vital in planning and developing agriculture and water conservation projects. Hence, the present study investigated the spa...
Article
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Allostatic load (AL) exposure may cause detrimental effects on the neuroendocrine system, leading to metabolic syndrome (MetS). The primary mediators of AL involve serum dehydroepiandrosterone sulfate (DHEAS; a functional HPA axis antagonist); further, cortisol, urinary norepinephrine (NE), and epinephrine (EPI) excretion levels (assessed within 12...
Article
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The COVID-19 pandemic represents an unprecedented challenge for clinical research. The Pneumococcal Vaccine Schedules (PVS) study is a non-inferiority, interventional trial in which infants resident in 68 geographic clusters are randomised to two different schedules for pneumococcal vaccination. From September 2019 onwards, all infants resident in...
Article
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Extreme precipitation could result in many disasters, such as floods, drought, and soil erosion, further bringing severe economic loss. Based on the daily precipitation records during 1960–2019 of 26 stations obtained from the National Meteorological Science Data Center of China, 10 extreme precipitation indices (EPIs: annual total precipitation (P...
Article
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Background: Worldwide mountain regions are recognized as hotspots of ethnopharmacologically relevant species diversity. In South Tyrol (Southern Alps, Italy), and due to the region’s high plant diversity and isolated population, a unique traditional botanical knowledge of medicinal plants has flourished, which traces its history back to prehistoric...
Article
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Background Infant sunlight exposure in their early infancy is essential for the cutaneous synthesis of vitamin D. Vitamin D deficiency is highly prevalent due to inadequate exposure to sunlight. In Ethiopia, one in thirteen children had rickets, which could be prevented by sunlight exposure or supplementation. This study aimed to identify the pract...
Article
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Pimenta racemosa is a commonly known spice used in traditional medicine to treat several ailments. In this study, comprehensive phytochemical profiling of the essential oils and methanol extracts of P. racemosa leaves and stems was performed, alongside assessing their potential Helicobacter pylori inhibitory activity in vitro and in silico. The ess...
Article
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Understanding the impacts of human activities on extreme precipitation events at different socioeconomic development levels (SEDLs) is critical for humans to tackle extreme events. This research aims to investigate the temporal variations of six extreme precipitation indices (EPIs) over 2000–2018 at different SEDLs for the selected 525 sites (consi...
Article
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O objetivo deste estudo foi analisar a disponibilidade e o uso de Equipamentos de Proteção Individual (EPIs), por profissionais de saúde bucal do sistema público de saúde do Paraná, durante a primeira onda da pandemia de COVID-19. Estudo transversal, realizado entre agosto e outubro de 2020, com utilização de questionário online enviado aos cirurgi...
Article
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Clonal propagation is frequently used in commercial plant breeding and biotechnology programs because it minimizes genetic variation, yet it is not uncommon to observe clonal plants with stable phenotypic changes, a phenomenon known as somaclonal variation. Several studies have linked epigenetic modifications induced during regeneration with this n...
Article
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Garments washing is the process of altering the aesthetic look, luxury, fashion, and comfortability of a garment after it has been manufactured. Most garments nowadays go through many washing processes before being sold in retail outlets. As denim is one of the most adaptable fabrics available today, the aesthetics may be reinvented in an infinite...
Article
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Though the right hemisphere has been implicated in talker processing, it is thought to play a minimal role in phonetic processing, at least relative to the left hemisphere. Recent evidence suggests that the right posterior temporal cortex may support learning of phonetic variation associated with a specific talker. In the current study, listeners h...
Article
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b>Antecedentes: Con frecuencia, los pacientes con enfermedades pulmonares intersticiales (EPI) presentan resultados no-diagnósticos en la tomografía computarizada de alta resolución (TCAR) y el lavado broncoalveolar (LBA), lo que hace necesario realizar una biopsia quirúrgica o criopulmonar invasiva, que se asocia con morbilidad significativa. La e...
Article
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The exocrine pancreas plays an important role in digestion. Understanding of the physiology and regulation of exocrine function provides insight into disease processes and basis of functional testing. Specifically, exocrine pancreatic insufficiency (EPI) can cause maldigestion and thus a proper assessment of exocrine pancreatic function is importan...
Poster
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Mouse preimplantation development Role of cavity size and p38-MAPK in cell lineage formation Pharmacological inhibition of cavity expansion Immunosurgery-ICM cultivation During preimplantation embryonic development, three transient cellular lineages are established. Whereas trophectoderm (TE) and primitive endoderm (PrE) give rise to extraembryonic...
Article
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Biological invasions may result from multiple introductions, which might compensate for reduced gene pools caused by bottleneck events, but could also dilute adaptive processes. A previous common-garden experiment showed heritable latitudinal clines in fitness-related traits in the invasive goldenrod Solidago canadensis in Central Europe. These lat...
Article
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Background and Aims Pancreatic enzyme replacement therapy (PERT) is most commonly used to treat exocrine insufficiency related to pancreatic diseases, but can be used for non-pancreatic digestive conditions (NPDC). We aimed to determine the prevalence of PERT use and describe prescription patterns in individuals with NPDC. Methods A nationally rep...
Article
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Fatty acid oxidation disorders (FAODs) are inborn errors of metabolism (IEMs) caused by defects in the fatty acid (FA) mitochondrial β-oxidation. The most common FAODs are characterized by the accumulation of medium-chain FAs and long-chain (3-hydroxy) FAs (and their carnitine derivatives), respectively. These deregulations are associated with lipo...
Conference Paper
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Advertising is often considered to bring bad impact on society, ranging from consumerism to fraud against consumers. Therefore, Indonesian Advertising Ethics (EPI) becomes a control function to Indonesia’s advertising industry. Since its presence in2007, which is a refinement of Indonesian Advertising Code of Conduct and Procedures(TKTCPI),there ar...
Article
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Durante a pandemia de COVID-19, a redução na produção e distribuição de diversos equipamentos de proteção individual (EPI), em especial, as máscaras N95, emergiu a necessidade de desenvolver um dispositivo local para desinfecção destes EPI, utilizando-se a radiação ultravioleta C (UV-C), aumentando a segurança dos usuários em caso de reuso desses e...
Article
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INTRODUÇÃO: Com a mudança repentina no cotidiano das instituições de saúde, causada pela pandemia por Covid-19, a saúde mental dos trabalhadores de saúde da linha de frente ficou abalada. Pode-se dizer que houve o agravamento da precarização do trabalho, com escassez de pessoal, de equipamentos de proteção individual (EPI), fragilidade nos vínculos...
Article
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Introdução: Em dezembro de 2019, teve início o surto causado pelo coronavírus da síndrome respiratória aguda grave 2 (SARS-CoV-2), agente etiológico da covid-19, afetando todos os países. No início do contágio, órgãos competentes em saúde enfatizaram os riscos para profissionais de laboratórios clínicos devido ao contato frequente com amostras cont...
Article
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Introduction and aim: Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide synthase, a marker of endothelial damage and progression of atherosclerosis. Research confirms the association of ADMA with an increased risk of cardiac complications and an increased risk of death, graft loss among kidney transplant rec...
Article
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To make steps in society towards a more sustainable future, countries must meet the targets established by the United Nations’ Sustainable Development Goals. Thus, factors that could impact the environmental indicators should be analysed. Therefore, this study aims to identify the correlations between financial development and environmental perform...
Article
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Objetivo: Identificar os desafios e as potencialidades para a prática clínica do enfermeiro na atenção primária à saúde frente à COVID-19. Método: Scoping Review, conforme Joanna Briggs Institute (JBI), com a questão norteadora: “Quais os desafios e as potencialidades da prática clínica do enfermeiro na atenção primária à saúde frente à COVID-19?”....
Article
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Single edge-notched three-point bending tests (SEN-TPB) for mode I were utilized to experimentally evaluate fracture properties of adhesive bondlines in European beech (Fagus Sylvatica L.). The bondline was examined at two anatomical planes with TR and RT orientation and at control and two elevated temperatures (70°C and 140°C). Among epoxy (EPI),...
Article
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Within the 2,5-dioxopiperazine-containing natural products generated by “head-to-tail” cyclization of peptides, those derived from tryptophan allow further structural diversification due to the rich chemical reactivity of the indole heterocycle, which can generate tetracyclic fragments of hexahydropyrrolo[2,3-b]indole or pyrrolidinoindoline skeleto...
Article
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Sticky platelet syndrome (SPS) is a thrombophilia caused by the increased aggregability of platelets in response to the addition of low concentrations of epinephrine (EPI) and/or adenosine diphosphate (ADP). Some of the single nucleotide polymorphisms (SNP), alleles and haplotypes of platelet glycoprotein receptors were proved to have a role in the...
Article
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Background: Community clinics (CC) have been restarted in 2009 by the government of Bangladesh through a project called “Revitalization of Community Health Care Initiatives in Bangladesh” (RCHCIB) to accomplish the ambitious project of establishing 18,000 community clinics. Since then 10,723 Community clinics have been established and they provide...
Article
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The interactions between electrons and antiferromagnetic magnons (AFMMs) are important for a large class of correlated materials. For example, they are the most plausible pairing glues in high-temperature superconductors, such as cuprates and iron-based superconductors. However, unlike electron-phonon interactions (EPIs), clear-cut observations reg...
Article
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The oxidative decomposition/degradation of two main tea flavanols, EGCG/GCG and ECG/CG, was studied in alkaline solution under ultrasonic-assisted thermal conditions. The study employed HPLC–ESI-ToF-MS to identify the products generated by atmospheric oxygen oxidation and various base-catalyzed reactions. Strong basic condition led to accelerated h...
Article
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Type 2 diabetes is a common and costly chronic disease in general as well as in the working population and its prevalence is increasing at an alarming rate. There are approximately 3000 healthcare professionals working in Rashid Hospital in different specialties. Objective: This study aimed to determine the prevalence of Type2 Diabetes risk among h...
Article
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Breast cancer is one of the most common types of malignancies in women worldwide. Cytotoxic chemotherapy has improved the prognosis of aggressive phenotype of breast cancer patients including triple-negative breast cancers. However, resistance to chemotherapy is an important problem. Tumor-associated macrophages (TAMs) are primary components of tum...
Article
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Objectives Pseudohypoparathyroidism (PHP) is a rare disease, especially when combined with pregnancy. We aimed to explore the changes in serum calcium/parathyroid hormone (PTH) level and medical treatment in a case series of PHP during pregnancy and the postpartum period. Methods A total of five PHP patients with six pregnancies were enrolled. The...
Article
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Over the last 50 years, the use of wood adhesives in the manufacturing of wood-based panel goods has increased the efficiency of wood resources. Wood adhesives are becoming more popular as the need for wood-based panels grows. By 2028, the global market for wood adhesives is expected to reach 21.8 billion dollars. Even though urea-formaldehyde (UF)...
Article
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Approximately one-third of patients with early psychosis disengage from services before the end of treatment. We sought to understand patient and family perspectives on early psychosis intervention (EPI) service engagement and use these findings to elucidate factors associated with early disengagement, defined as dropout from EPI in the first 9 mon...
Article
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Objective The purpose of this study was to conduct a network meta-analysis comparing the diagnostic value of different urinary markers for prostate cancer. Methods As of June 2022, the literature was retrieved by searching Pubmed, EMBASE, Web of Science databases and other databases. The methodological quality of included studies was assessed usin...
Article
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Background Paragangliomas are neuroendocrine tumors that arise from embryonic neural crest cells; they are essentially extra-adrenal pheochromocytomas most frequently found in the head and neck. Composite tumors are rare and consist of the presence of two histologically distinct tissues within a single tumor. Additionally rare is the presence of a...
Article
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Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www.licpathway.net/sedb) aims to provide a comprehensive SE resource and annotate their potential roles in gene transcriptions. Compared with SEdb 1.0, we have made the following impro...
Article
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Background and purpose Dose-escalation in rectal cancer (RCa) may result in an increased complete response rate and thereby enable omission of surgery and organ preservation. In order to implement dose-escalation, it is crucial to develop a technique that allows for accurate image-guided radiotherapy. The aim of the current study was to determine t...
Article
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Background Every year, hundreds of millions of individuals are afflicted by preventable illnesses in the health care system. In surgical patients in Sub-Saharan Africa, the rate of nosocomial infection ranges from 2.5 to 30.9%. Anesthesia doctors have a direct impact on the risk of perioperative infection. In the operating theater, 7% of surgical p...
Article
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Heliocheilus albipunctella de Joannis est un ravageur endémique de la zone sahélienne qui occasionne d’importants dégâts sur la culture de mil. Durant les saisons pluviales 2016 à 2018, une étude relative à ses infestations a été conduite dans la bande sud agricole du Niger. Des pièges lumineux ont été installés dans 9 localités des régions de...
Article
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Rezime Grafi kreyòl ayisyen an, yo ofisyalize an janvye 1980, genyen yon karaktè fonografik epi li baze sou yon prensip yo rele devyans maksimal. Tout moun aksepte li e adopte li, men genyen kèk eleman ki konsène fenomèn lengwistik yo rele sandi a ki poze pwoblèm nan fason nou dwe ekri yo. Nan sans sa a, tankou kreyòl matinikè ak gwadloupeyen, pa e...
Article
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Apples are a rich source of polyphenols in the human diet. However, the distribution of polyphenols in different apple varieties and tissues is still largely unclear. In this study, a new liquid chromatography–tandem mass spectrometry (LC-MS/MS) strategy was developed to reveal the spatial distribution of polyphenols in different apple tissues and...
Article
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The multidrug efflux transporters MexB and MexY in Pseudomonas aeruginosa and AcrB in Escherichia coli contribute to these organisms' multidrug resistance. Efflux pump inhibitor (EPI) ABI-PP inhibits MexB and AcrB, but not MexY. We previously determined the structure of ABI-PP bound to the hydrophobic trap (the inhibitor-binding pit) of AcrB and Me...
Article
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Objetivo: investigar os impactos na saúde mental dos profissionais da enfermagem envolvidos diretamente no combate a COVID-19. Metodologia: foi realizado uma revisão integrativa. Sendo realizadas buscas por materiais publicados em bases de dados no período de novembro de 2019 a setembro de 2021, utilizando os descritores “pandemia”, “COVID-19”, “en...
Preprint
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Background Childhood HBV immunization remains globally fundamental to the elimination of hepatitis B virus (HBV). However the African paediatric HBV vaccine sero-protection rates and their determinants are crucial to establish; as they remain inconclusively studied. We sought to verify the extent of immune protection accorded by HBV vaccine to Afri...
Article
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The “edible rhizome” variant of Nelumbo nucifera with various cultivars has a long history of use as a food in East Asia. In this study, 48 target metabolites were untargeted and identified in 212 rhizome cultivars (tropical and temperate types) using ultraperformance liquid chromatography-electrospray ionization quadrupole time-of-flight high-reso...
Article
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The project aim to support Sierra Leone in enhancing vaccination coverage. BACKGROUND In November 2021, the vaccination coverage rate was 7% for one dose and 4% for two. According with EPI program, the main problem was not the lack of vaccines (already provided by different donors) but the need of support (training, motivation, allowances) to healt...