Science topic
Enzymes - Science topic
Biological molecules that possess catalytic activity. They may occur naturally or be synthetically created. Enzymes are usually proteins, however CATALYTIC RNA and CATALYTIC DNA molecules have also been identified.
Publications related to Enzymes (10,000)
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The objective of this paper is to find new dynamic perspectives in a well-known two dimensional nonlinear system which is a modification of the phosphofructo kinase model by incorporating recycling of the product, p, into the substrate, s. Specifically, we investigate the affect of the negative cooperativity on the number of equilibria and their st...
الخلاصة الالتهاب هو آلية مهمة للحماية والبقاء على قيد الحياة ضد المنبهات السامة والصدمات الجسدية. كان الهدف من هذه الدراسة استخدام الارساء الجزيئي لتصميم ودراسة ستة مشتقات جديدة من البيرازولين والبيريميدين وتحديد تأثيرها المضاد للالتهابات حيث قد يكون لها القدرة على تثبيط إنزيم السايكلواوكساجينيز-2 الذي يلعب دورًا مهمًا أثناء عملية الالتهاب. تم التن...
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Thymidylate Synthetase strongly binds to Rna. As RSV Virus is rna virus so treating thymidylate synthetase enzyme with rsv virus causes the enzyme which can bind to rna of other cellular species like of the concerned virus causes mutation in the virus and thus leads to its death. As thymidylate synthetase is an rna binding protein. So it may kill t...
The application of the standard quasi-steady-state approximation to the Michaelis--Menten reaction mechanism is a textbook example of biochemical model reduction, derived using singular perturbation theory. However, determining the specific biochemical conditions that dictate the validity of the standard quasi-steady-state approximation remains a c...
Particulate methane monooxygenase (pMMO) is the most efficient of the two groups of enzymes that can hydroxylate methane. The enzyme is membrane bound and therefore hard to study experimentally. For...
This study improves electron transfer in biofuel cell anodes through a spin coating-assisted layer-by-layer assembly of redox-active ferritin and enzyme, resulting in enhanced current density, stability, and biocompatibility for energy applications.
Sportininkų genetiniai tyrimai vis populiarėja. Vienas labiausiai ištirtų su fiziniu pasirengimu siejamų genų kandidatų yra ACE (angl. angiotensin-converting enzyme) genas ir jo polimorfizmas rs1799752 (I/D). Šio tyrimo tikslas buvo išanalizuoti ir įvertinti ACE rs1799752 polimorfizmo ypatumus Lietuvos profesionalių futbolininkų grupėje. Tyrimas...
Kesadaran lingkungan adalah sikap dan tindakan yang selalu berupaya mencegah kerusakan pada lingkungan di sekitarnya. Menjaga lingkungan merupakan sikap manusia yang dapat dididik atau diubah dengan pendidikan formal, dengan menanamkan sikap atau peduli terhadap lingkungan. Lingkungan dapat dijadikan sebagai sumber belajar yang diterapkan dalam pro...
Background and Aim: Zinc is essential for several body processes and may help babies with
Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity. These characteristics ma...
The objective of this study was to determine the antimicrobial activity of proteolytic, meat-tenderizing enzymes (papain and bromelain) against E. coli and L. monocytogenes at three different temperatures (5, 25 and 35°C). Two overnight cultures of E. coli JM109 and L. monocytogenes were separately suspended in 1% peptone water and exposed to a pro...
Eco enzyme merupakan produk pengolahan limbah rumah tangga yang berasal dari sisa sayuran atau buah-buahan. Eco enzyme dapat dijadikan sebagai bahan aktif untuk membuat produk kebersihan rumah tangga diantaranya detergen cair ramah lingkungan. Pembuatan detergen cair berbasis eco enzym memiliki peluang untuk dijadikan sebagai kegiatan home industry...
The concept of continuous education, technology integration, and increasing environmental awareness is a good synergy in learning. Continuing education is a holistic approach. The teaching materials developed not only focus on the use of eco enzymes, but also relate them to broader sustainability issues. The purpose of this study is to describe the...
In this study, the reaction rates of native degerminated maize, extruded degerminated maize and enzymatically extruded degerminated maize using glucoamylase were evaluated and the extrudate models were investigated. The effects of enzyme concentration, substrate pH, temperature and incubation time on the reaction rates were studied. The Lineweaver–...
Gaucher's disease is a lysosomal storage disorder of autosomal recessive inheritance. Clinical manifestations of disease are due to accumulation of glucocerebroside characterised by hereditary deficiency of enzyme beta-glucosidase. We hereby present three cases with Gaucher's disease having variable clinical presentation.
Classic Enzyme adalah cairan yang dihasilkan dari buah-buahan melalui proses fermentasi dengan waktu panen 1 tahun. Bakteri Asam Laktat dapat di isolasi dari minuman Classic Enzyme. Tujuan Penelitian ini adalah untuk mengisolasi dan mendapatkan daya hambat antibakteri dari isolat BAL yang terdapat pada minuman classic enzyme. Penelitian ini merupak...
The spontaneous emergence of lipid vesicles in the absence of evolved biological machinery represents a major challenge for bottom‐up synthetic biology. We show that coacervate microdroplets could create a compartmentalized environment that enriches lipid molecules and facilitates their spontaneous assembly into lipid vesicles. These vesicles can e...
The first paper in this Special Issue explores the synthesis, characterization, biological, and catalytic activities of new gold(I) and silver(I) complexes that are stabilized by caffeine derivatives and used as NHC ligands [...]
Glu178 is the active site residue essential for substrate affinity and catalytic activity of the aspartoacylase enzyme. Sanger sequencing in an infant with Canavan disease revealed a homozygous ASPA: c.532G>A: p. (Glu178Lys) variant. Glu178Lys is the first ever variant reported at the critical active site of aspartoacylase protein and this variant...
The enzyme carbonic anhydrase has been intensely studied over decades as a means to understand the role of zinc in hydrating CO2. The naturally occuring enzyme has also been immobilized...
Several observational studies have indicated a potential protective effect of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) against lung cancer. These investigations have demonstrated a reduced risk of lung cancer among individuals utilizing ACEIs or ARBs compared to those not receiving these medications....
Succinate dehydrogenase (SDH)-deficient renal cell carcinoma (RCC) is a rare subtype of RCC characterized by the presence of a germline mutation in one of the four subunits of the SDH enzyme complex (SDHA, SDHB, SDHC and SDHD). Together with a somatic second hit, these variants lead to the loss of function of the SDH complex. SDH-deficient RCC asso...
Inborn errors of metabolism (IEM) are a large group of single-gene disorders resulting from enzyme defects in biochemical and metabolic pathways [...]
Enzymes unchained – enzymes immobilised on nanoparticles with a cleavable linker and shielded in an organosilica layer are activated upon reductive breakage of the linker. The organosilica layer prevents enzyme leaching.
DNA molecules are a promising data storage medium for the future; however, effective de novo synthesis of DNA using an enzyme that catalyzes the polymerization of natural nucleoside triphosphates in...
Photo‐enzyme coupling system are receiving widespread attention due to the unique opportunity by integrating photochemistry with nature's enzymatic machinery. Here we highlight a recent work about MOF encapsulated tandem enzymes for photoenzymatic CO2 conversion, and provide an outlook for the further development of photo‐enzyme systems for green b...
Several chemical and biocatalytic methods have been described for chiral γ-lactams syntheses. However, only one biocatalytic method has been reported for γ 4-lactam resolution, while γ 2-and γ 3-lactams have not been reported. On the other hand, its resolution through biocatalysts is complicated since enzymes such as ENZA-1 (Rhodococcus equi NCIB 4...
Breast cancer is a major health problem, accounting for one third of all cancers in women. There is no definitive treatment for breast cancer and its incidence is increasing worldwide every year. Furthermore, breast cancer stem cells cause resistance to radiation and chemotherapy. Telomerase is an enzyme that protects telomeres and is activated in...
Background: Zebra bodies are intracellular lamellar inclusions detected by electron microscopy (EM) on renal biopsy, classically found in Fabry disease. This EM finding prompts genetic testing for α-galactosidase A enzyme deficiency to diagnose Fabry disease, and thus consider enzyme replacement therapy. Zebra bodies have also been associated with...
We conducted an additional analysis using the data from the post-marketing surveillance of Alglucosidase alfa for Pompe disease. We aimed to investigate the changes in the percentage of predicted forced vital capacity (%FVC) and the changes in the distance of the 6-min walk test (6MWT) by overall improvement and to investigate the %FVC change by th...
Introdução: Os recursos didáticos de e-learning ou ensino eletrônico tem sido amplamente utilizados nos últimos anos devido ao avanço das novas tecnologias de informação e comunicação e às necessidades impostas durante a pandemia da covid-19. Uma das ferramentas desenvolvidas para o ensino eletrônico foi o LabXchange, que apresenta a animação Restr...
α-Ketoglutarate-dependent non-haem iron (αKG-NHFe) enzymes play a crucial role in natural product biosynthesis, and in some cases exhibiting multifunctional catalysis capability. This study focuses on an αKG-NHFe enzyme FtmOx1, which...
Over the past years, enzymatic depolymerization of PET, one of the most widely used plastics worldwide, has become very efficient leading to the end products terephthalic acid (TPA) and ethylene glycol (EG) used for PET re‐synthesis. Potent alternatives to these monomers are the intermediates BHET and MHET, the mono‐ and di‐esters of TPA and EG whi...
Pembuatan ecoenzym dari rumput laut Sargassum sp. melibatkan proses fermentasi yang memanfaatkan bahan organik. Dalam metode ini, Sargassum dicuci, dipotong kecil-kecil, dan dicampurkan dengan molase serta air dalam wadah tertutup. Proses fermentasi berlangsung selama tujuh hari, di mana gas yang dihasilkan dikeluarkan untuk mencegah ledakan. Ecoen...
The objective of this study was to evaluate the activity of the enzyme nitrate reductase in ‘Syrah’ grapevine under three irrigation strategies. Irrigation was applied by a drip system, and the treatments were started 45 days after production pruning. The statistical design was completely randomized in a 3 x 5 factorial, corresponding to three irri...