Questions related to Endometriosis
I am studying endometriosis and am particularly interested in lesions of the pelvic peritoneum. I have been scouring literature looking for papers that describe the Stress/Strain or Elastic Modulus of the pelvic peritoneum or even regions of the pelvic peritoneum. Does anyone have recommendations for labs to potentially reach out to or who might have data on this subject?
Thanks in advance!
I am doing my research in the area of endometriosis and I need to find out the volume and surface area of an endometrial lesion in rat model .Can any one pls suggest how to calculate it.
These are cell lines being used for endometriosis research. I am trying to buy them but couldn't find any website selling them. I have reached them out from review papers and especially a study conducted by Banu et al from Texas University. I am planning to form a drug study and came to a decision that these would be proper for my design. I would appreciate if you could suggest me website or different cell line options that could be proper for drug studies.
Hello dear colleagues,
I have a patient who had 2 episodes of venous thromboembolism once in pregnancy and undergoing hip surgery, and the second one after an episode of COVID-19 infection. She had a history of endometriosis surgery before and now needs to receive suppressive therapy to prevent the recurrence of endometriosis. Regarding her history of VTE what could be prescribed for her to prevent endometriosis recurrence? Is LNG-IUD (Mirena) a safe option in this case?
Hello, everyone. I'm doing a research on the regulation of HOXA10 by miRNAs in endometriosis and I'm having a difficult time to find the endometriotic cell line currently. May I know where can I get the cell line beside ATCC (since they don't have the supply now)?
Thank you for the help
Endometriosis is defined and diagnosed surgically by the appearance of endometrial-like stroma and glands in the sites exterior to the uterus (Denny et al, 2007). It would be interesting to find out and learn the diagnosis, treatment, prevalence of endometriosis in Indian women. Also, are they being referred to a women's health physiotherapist?
I'm trying to locate articles on endometriosis and suicide . I've searched extensively to no avail. Wondering if there are any publications regarding this matter or is it not discussed ? Thanks Lisa
Link-> Endometriosis: Women 'taking their own lives' due to lack of support - World News Empire
Recently, I am curious to know about mechanisms of endometriosis and signaling pathways.
I have a question about the difference between signaling pathways in benign tumors and malignant tumors.
Since I studied, I noticed that the signaling pathway involved in benign and cancerous cells is similar, like MAPK signaling, Wnt Signaling, Apoptosis, Cell adhesion and angiogenesis.
So, what is the difference between endometriosis and ovary cancer in terms of pathway ?
Thank you in advance.
Should we use dianogest or other medical treatment for minimizing the ectopic endometrial lesion before endometriosis surgery? If yes, how long and what is the dose?
Moreover, when an endometriosis patient has an indication for COH cycle or endometrial preparation for embryo transfer, and she is using dianogest, how should we manage this patient? After stop using dianogest, can we directly apply ART after the first menstrual bleeding?
Thank you for reading and looking forward to all your experience.
Am planning to do a cross sectional study to find cancer prevalence in endometriosis, can I attach a abbreviated follow up component for the cancer patients
Over the last two decades, there has been growing evidence suggesting that radiotherapy could be used to treat inoperable and refractory endometriosis via induction of menopause.
Can and should RT be used in other "types" of endo, such as DIE or superficial, without the need of inducing premature menopause. Is there a model that could be developed (ex. micobeam or low dose)?
Since many endometriosis patients are unable to have elective surgery right now, there is a general feeling of uncertainty and hopelessness. They might be able to access hormonal and/or non-hormonal medications through telehealth.
We know in endometriosis and chronic pelvic pain, multidisciplinary management strategies are useful (though the evidence is scarce for many).
What do you think is the single-most useful COMPLEMENTARY and ALTERNATIVE (CAM) management strategy patients with endometriosis can use to cope with pain during this difficult period?
There is research that shows that lycopene can be supportive in reducing endometriosis. If that is the case do people from Mediterranean countries have a lower risk as they are likely to have more Lycopene in their diets?
My name is Liza , and I an a a gynecologist and researcher from London. I am conducting a meta analysis on predictors of surgical success in endometriosis.
Did you do a longer term follow up study after the study
The effect of endometriosis and its radical laparoscopic excision on quality of life indicators BJOG 2000, you reported?
I am looking forward to your reply
I have discovered through my experience that gynicological infection is the most common cause, especially when its chronic and neglected, however; minimal could be refered to hormonal changes or endometriosis. Now I working on research regarding this question to find out suitable answer.
I need your help.Last year I was informed that I am suffering from endometriosis (DIE,stage iv). From last april to till now I am taking Levonoregestrel(.10 mg) anf etinyl estradiol(.02mg) as Loette ocp with 84 days cycle. before that for 6 months I had taken De-Provera 150mg injection (2 months interval).But still I am having tremendous unbearable pain.I live in India. I don't know is there any integrative type of treatment or not.I am 26 and I don't want to go for hystectomy and event don't know how much it will be successful.If you can guide me it will be really very much helpful to me, to my work and research because sometimes it seems to me that I perhaps I wd have to quit my work as almost 15 days I suffer in every month.
Recently I've experienced strange finding in hysterectomy specimen with multiple myomas and adenomyosis and endometriosis in the serosal surface. Several clusters of endometrial tissue was found in the parametrial blood vessels and attached to the vessel lumen which doesn't seem to be just tissue contamination. What do I have to consider in this lesion?
placenta derived matrix could be potential regenerative medicine for endometriosis, a disease with reference to women reproductive health. Any links will be highly appreciated.
I came across a study talking about endometriosis and its lack of treatment. For the naive student that I am, one would be able to develop a drug that would target the vaginal staphylococci (or inhibit the toxin they secrete and that is responsible for the symptoms of the disease). As for now, no such drug exist, does any of you have any idea why ?
hey guys, do you know more about that why the VEGF was highly expressed in stromal cells but not in epithelial cells of endomertiosis lesions? pls help me to understand
A 33 yr woman with 8.4 weeks estimated gestational age with last menstrual period revealed following reports on transvaginal ultra-sonography:
1. Bulky uterus
2. Single gestation sac of about 5.43X4.62X3.34 cm size in uterine cavity.
3. Crown to rump length of embryo is 16.3 mm which correspond to 8.2 weeks of gestation.
4. Normal yolk sac seen in gestation sac.
5. Trophoblastic rim is normal in thickness and ecogenicity. A small anechoic area seen right laterally.
6. Gestation sac contains single embroyo without cardiac pulsations.
Pathology impression: finding suggstive of missed abortion. Minimal separation of membranes noted.
Physician recommend to undergo D&C (dilation and curettage). What would be the actual action to be taken under such circumstances i.e. D&C or wait for few weeks. Is such kind of sonography reports are always true.
miRNAs used: mimics for both 125b and let7B (will work with inhibitors also since this is a product of an endometriosis paper done previously)
transfection reagent: RNAimax
have read about bioactive peptides in food with potential health benefits and much research in this area but also have seen references to a RICE peptide=RGD--that has embryotoxicity at least in lab animals. This RGD is described as a LAMININ-like peptide involved in immune mediated reproductive failure. I am also aware of reports of anti-LAMININ antibodies found in women with endometriosis and infertility. Is there any evidence of this RGD embryotoxicity in humans, or any cross reactivity beween the RICE RGD and HUMAN LAMININ---I am totally unaware of any dietary implications related to RICE on pregnancy---any data at all in this context?
I need two cell lines to perform a study in endometriosis and normal endometrium but which kind of cell lines are more suitable to perform this kind of study?
thank you in advance!!
Besides abdominal pain, subfertility is the second key symptom in patients suffering from endometriosis. Details of the model I am searchng for a described in the attached flyer.
We at the Endometriosis Association are beginning another capital campaign to fund research as we've done throughout our 35 year history (over $29 million direct & indirect so far). We're pondering how best to prioritize research aims and are interested in feedback from the research community.
I am struggling with subculturing mouse endometrial cells using trypsin/EDTA and a cell scraper. I have no problem isolating the cells, but when they become confluent and they are due to be subcultured, they stop growing and die following trypsinisation/scraping.
Can anyone suggest any alternative method I could use to successfully lift off the cells and seed them into a new flask?
Endometriosis needs to be addressed with proper therapeutic molecules. Biosimilars are probably the answer. What phytochemicals are promising in this effort?
Levels of cytokines/chemokines can vary depending on the time of day the blood sample is collected, stress level of the patient and how the blood was collected. Accounting for these factors is important in my opinion. Also, why aren't Il-10 and IL-12 results also reported as a ratio to give a better indication of the immune status in endometriosis?
I need help because I have recieved a 39 years old patient who had been submitted to Abdominal Hysterectomy for endometriosis in January, 2013 but she maintains abdominal-pelvic pain chart and to make worse all that, she has Lupus so I have doubts concerning what might be the best approach for the case and if is posible to use progesterone for her. I think it is not a surgical case because there is no identified focus at MR.
Thanks for your help
Can anyone share an aliquot of immortalized endometrial stromal and epithelial cells (not from cancers like the ISHIKAWA cells)? I also need cells from ectopic endometrium. I am willing to sign the MTA and the necessary formalities, it's quite urgent.