Science topic

Endometriosis - Science topic

A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
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Hello all,
I am studying endometriosis and am particularly interested in lesions of the pelvic peritoneum. I have been scouring literature looking for papers that describe the Stress/Strain or Elastic Modulus of the pelvic peritoneum or even regions of the pelvic peritoneum. Does anyone have recommendations for labs to potentially reach out to or who might have data on this subject?
Thanks in advance!
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Some of these publications may have contact with labs involved with Elastic Modulus of the pelvic floor, and its parameters related to so many variables.
2.
Biomechanical properties of prolapsed vaginal tissue in pre- and postmenopausal women.
Int Urogynecol J Pelvic Floor Dysfunct. 2002; 13: 76-79
3.
Biomechanical properties of prolapsed vaginal tissue in pre- and postmenopausal women.
Int Urogynecol J Pelvic Floor Dysfunct. 2007; 18: 603-607
4.
Biomechanical properties of prolapsed or non-prolapsed vaginal tissue: impact on genital prolapse surgery.
Int Urogynecol J. 2010; 21: 1535-1538
5.
Mechanical properties of pelvic soft tissue of young women and impact of aging.
Int Urogynecol J. 2014; 25: 1547-1553
6.Fung Y.C.
Biomechanics: mechanical properties of living tissues.
ed. 2. Springer, New York, NY1993
7.
Tissue mechanics.
Springer, New York, NY2007
Hope this helps with links to the appropriate labs.
Best wishes.
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I am doing my research in the area of endometriosis and I need to find out the volume and surface area of an endometrial lesion in rat model .Can any one pls suggest how to calculate it.
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Thankyou for your reply. Can you pls explain what is this factor 0.5
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Usually surgery is the treatment for endometriosis. Is Magnetic hyperthermiae would be better then surgery for its management.
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These are cell lines being used for endometriosis research. I am trying to buy them but couldn't find any website selling them. I have reached them out from review papers and especially a study conducted by Banu et al from Texas University. I am planning to form a drug study and came to a decision that these would be proper for my design. I would appreciate if you could suggest me website or different cell line options that could be proper for drug studies.
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Sorry, this topic is not in my field of science
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Hello dear colleagues,
I have a patient who had 2 episodes of venous thromboembolism once in pregnancy and undergoing hip surgery, and the second one after an episode of COVID-19 infection. She had a history of endometriosis surgery before and now needs to receive suppressive therapy to prevent the recurrence of endometriosis. Regarding her history of VTE what could be prescribed for her to prevent endometriosis recurrence? Is LNG-IUD (Mirena) a safe option in this case?
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Dear doctor Anahita,
i am in a good agreement with doctor Kumar answer's.. by using Gnrh analogues hormone.
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Hello, everyone. I'm doing a research on the regulation of HOXA10 by miRNAs in endometriosis and I'm having a difficult time to find the endometriotic cell line currently. May I know where can I get the cell line beside ATCC (since they don't have the supply now)?
Thank you for the help
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You can also contact the authors of the following paper:
They have performed a lot of work, including STR authentication on this particular cell line. The corresponding author is highly responsive.
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Endometriosis is defined and diagnosed surgically by the appearance of endometrial-like stroma and glands in the sites exterior to the uterus (Denny et al, 2007). It would be interesting to find out and learn the diagnosis, treatment, prevalence of endometriosis in Indian women. Also, are they being referred to a women's health physiotherapist?
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1. Trends in Endometriosis among Laparoscopic Patients in Multiple Hospitals in Northern India: A 3-Year Review
2. Study of endometriosis in women of reproductive age, laparoscopic
management and its outcome
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I'm trying to locate articles on endometriosis and suicide . I've searched extensively to no avail. Wondering if there are any publications regarding this matter or is it not discussed ? Thanks Lisa
Link-> Endometriosis: Women 'taking their own lives' due to lack of support - World News Empire
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HI Abdoulie, I managed to find below article on Linkedin as posted by world leader Endometriosis and Pelvic Pain Awareness: Infertility, Suicidal Ideation, and Cancer - Journal of Obstetrics and Gynaecology Canada (jogc.com) ,
A survey would be interesting indeed!!! Thanks Lisa
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Hello
Recently, I am curious to know about mechanisms of endometriosis and signaling pathways.
I have a question about the difference between signaling pathways in benign tumors and malignant tumors.
Since I studied, I noticed that the signaling pathway involved in benign and cancerous cells is similar, like MAPK signaling, Wnt Signaling, Apoptosis, Cell adhesion and angiogenesis.
So, what is the difference between endometriosis and ovary cancer in terms of pathway ?
Thank you in advance.
Kimiya
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It would be better to compare benign and malignant conditions in the same organ/tissue: endometriosis vs endometrial cancer, for example, instead of uterus compared with ovary tissue.
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Should we use dianogest or other medical treatment for minimizing the ectopic endometrial lesion before endometriosis surgery? If yes, how long and what is the dose?
Moreover, when an endometriosis patient has an indication for COH cycle or endometrial preparation for embryo transfer, and she is using dianogest, how should we manage this patient? After stop using dianogest, can we directly apply ART after the first menstrual bleeding?
Thank you for reading and looking forward to all your experience.
Best regard,
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According to the latest ESHRE guideline on the management of endometriosis, a Cochrane review on the preoperative hormonal treatment concluded that there was no evidence of a benefit of preoperative medical therapy on the outcome of surgery, but it also acknowledges that in clinical practice, surgeons prescribe preoperative medical treatment with GnRH analogues as this can facilitate surgery due to reduced inflammation, vascularisation of endometriosis lesions and adhesions. However, there are no controlled studies supporting this.
By the way, medical treatment should be offered preoperatively to women with painful symptoms in the waiting period before surgery, with the purpose of reducing pain before, not after, surgery.
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Am planning to do a cross sectional study to find cancer prevalence in endometriosis, can I attach a abbreviated follow up component for the cancer patients
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Yes you can.
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Over the last two decades, there has been growing evidence suggesting that radiotherapy could be used to treat inoperable and refractory endometriosis via induction of menopause.
Can and should RT be used in other "types" of endo, such as DIE or superficial, without the need of inducing premature menopause. Is there a model that could be developed (ex. micobeam or low dose)?
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Radiotherapy is generally not used in treatment of endometriosis. Treatment of endometriosis is by medicines or surgery depending on patients symptoms and extent of endometriosis. radiotherapy is mainly used to treat malignant conditions.
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Since many endometriosis patients are unable to have elective surgery right now, there is a general feeling of uncertainty and hopelessness. They might be able to access hormonal and/or non-hormonal medications through telehealth.
We know in endometriosis and chronic pelvic pain, multidisciplinary management strategies are useful (though the evidence is scarce for many).
What do you think is the single-most useful COMPLEMENTARY and ALTERNATIVE (CAM) management strategy patients with endometriosis can use to cope with pain during this difficult period?
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Hey Matthew,
Very neat topic!!
In regards to alternative/complementary at-home interventions, two came to mind:
1) There has been growing evidence suggesting that moderate cannabis use could help mitigate pain in endo through several MOA. Several cross-sec studies have shown that cannabis is one of the most frequently used non-pharmaceutical interventions amongst patients with endo. Cannabinoid receptors (CB1) have been found at the somatic fibres adjacent to the lesion site. Several murine studies have shown the potential of cannabinoids in drastically reducing pain scores and even reducing the lesion.
In general, especially in areas such as Canada or America, cannabis is widely accessible. Although the caveat remains, as there is not enough literature to fully support the clause due to variation in cannabis and route of administration.
2) I've noticed that the most frequently suggested intervention by women with endo over social media is changing diet. This could be a great way to reduce inflammation at home and improve overall health in some cases.
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If yes, please contact me here or the following e-mail address: zsuzsanna.kovacs@nibrt.ie and we can discuss the details. I'm looking for collaborators for my Marie-Curie research project. Please, see more information on this website: http://glycomendo.com/
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Yes, we can.
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How endometriosis cause sub-fertility?
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Endometriosis can cause infertility through different mechanisms : 1. Pelvic, tubal and uterine adhesions. 2. endometrial tissues secreted toxic substances which negatively affect spermatoza and decrease their fertilizing ability. 3. Vaginisimus, vaginal nodules or mass. 4. Ovulatory dysfunction in 10% of cases.
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There is research that shows that lycopene can be supportive in reducing endometriosis. If that is the case do people from Mediterranean countries have a lower risk as they are likely to have more Lycopene in their diets?
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There is no any concrete scientific evidence to prove that lycopene reduces the risk of endometriosis in Mediterrean countries.
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What is the reason of doing ovarectomy and then administer estrogen supplement to sustain the estrous cycle in endometriosis mice?
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The ovariectomised rodent model is used to determine the role of ovarian hormones (estrogens and progesterone) in whatever thing is being studied. In most cases, it is preferable to ovariectomise all groups and have one group (or more as needed) with added estrogen at a fixed dose, as opposed to have intact animals (i.e. not ovariectomised) in the same experiment. This is because the ovary goes through cycles of more or less hormone release. For most experiments is more useful to know exactly the amount of estrogens the animal is exposed to.
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Dear Ray,
My name is Liza , and I an a a gynecologist and researcher from London. I am conducting a meta analysis on predictors of surgical success in endometriosis.
Did you do a longer term follow up study after the study
The effect of endometriosis and its radical laparoscopic excision on quality of life indicators BJOG 2000, you reported?
I am looking forward to your reply
Liza ball
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For the study about the surgical success in endometriosis , you must consider too the NCT and the grade
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is there any relation between endometriosis and depression?
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This is an interesting review that addresses your question [28553145]. In brief, depression may be more prominent in women with severe symptomatology and also women with concurrent depression experience precipitated pain.
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I have discovered through my experience that gynicological infection is the most common cause, especially when its chronic and neglected, however; minimal could be refered to hormonal changes or endometriosis. Now I working on research regarding this question to find out suitable answer.
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It is important to differentiate the type of cyst. Each type has different etiology. Generally ovarian cysts can be classified into these categories: follicular cyst, corpus luteum cyst; endometrioma, dermoid cyct and cystadenoma. Polycystic ovarian (PCO) condition has many follicles that do not rupture.
Follicular cysts are due to disturbed LH release. Instead of rupturing the follicle, it lutenizes the inner follicular wall and the follicle stays on the ovary causing further hormonal disturbances like increased estrogen secretion and irregularity in periods.
Endometriomas are dark chocolate colour fluid filled cysts that develop on the ovary. They are linked to the endometriosis, etiology of which is of considerable debate. Menstrual contents spill out of the fallopian tubes and grow wherever they attach around the ovaries or uterus.
Corpus luteum cyst develops after follicle has ruptured. This type of cyst usually does not cause much hormonal disturbances and disappear after corpus luteum lysis. Dermoid cysts may contain fat or other tissue inside. Cystadenoma is non-cancerous growth on the outside of ovary.
Because you are doing research on the ovarian cysts, I suggest conducting thorough literature search as much work has already been done especially on endometriosis and polycystic ovarian syndrome (PCOS).
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Endometriosis cells CRL7566.
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Serum free generally means no serum. 
Many people include 0.1% BSA or FBS into their starvation protocol. Not because of stability but as a carrier protein since without it low concentrations of growth factors (either autocrine or added) will get absorbed by the plastic tubes and dishes. 
Some cells need a bit of FBS to survive, but many cancer cell lines can be in serum free media forever. 
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dear colleagues,
I need your help.Last year I was informed that I am suffering from endometriosis (DIE,stage iv). From last april to till now I am taking Levonoregestrel(.10 mg) anf etinyl estradiol(.02mg) as Loette ocp with 84 days cycle. before that for 6 months I had taken De-Provera 150mg injection (2 months interval).But still I am having tremendous unbearable pain.I live in India. I don't know is there any integrative type of treatment or not.I am 26 and I don't want to go for hystectomy and event don't know how much it will be successful.If you can guide me it will be really very much helpful to me, to my work and research because sometimes it seems to me that I perhaps I wd have to quit my work as almost 15 days I suffer in every month.
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Agree with@Huda Omran
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Recently I've experienced strange finding in hysterectomy specimen with multiple myomas and adenomyosis and endometriosis in the serosal surface. Several clusters of endometrial tissue was found in the parametrial blood vessels and attached to the vessel lumen which doesn't seem to be just tissue contamination. What do I have to consider in this lesion?
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Endometriosis can spread via blood and lymphatic vessels. This underestimated fact can explain several rare symptoms or histopathological findings, e.g. endometriosis within the sciatic nerve or endometriosis at very distant localisations. Please, see also: Tempfer CB et al. Lymphatic spread of endometriosis to pelvic sentinel lymph nodes: a prospective clinical study. Fertil Steril. 2011 Sep;96(3):692-6. doi: 10.1016/j.fertnstert.2011.06.070 or Zamurovic M. Rare extrapelvic endometriosis on iliac vein wall--diagnosis and treatment. Clin Exp Obstet Gynecol. 2014;41(3):349-50.
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placenta derived matrix could be potential regenerative medicine for endometriosis, a disease with reference to women reproductive health. Any links will be highly appreciated.
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hello basically we need a factor that limit proliferation of endometrial cells with available techniques it act in opposite way like in SVF of adipose
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I came across a study talking about endometriosis and its lack of treatment. For the naive student that I am, one would be able to develop a drug that would target the vaginal staphylococci (or inhibit the toxin they secrete and that is responsible for the symptoms of the disease). As for now, no such drug exist, does any of you have any idea why ? 
Thank you! 
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Endometriosis and endometritis are sometimes confused due to the word similarity but they are totally different entities.  Endometriosis has not been shown to be associated with an infection.  It is associated with inflammation.  
That is why there no antimicrobial drug for endometriosis.  
Good luck with your studies.
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hey guys, do you know more about that why the VEGF was highly expressed in stromal cells but not in epithelial cells of endomertiosis lesions? pls help me to understand 
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stroma is responsible for the activity of the disease , while glands isn`t active. over expression of VEGF is mandatory for neovascularisation and proliferation of the disease. but the epithelium and the glands also, express VEGF as well.
refer to : doi: 10.1093/humrep/13.6.1686 
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in endometriosis
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Thanks my friend
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A 33 yr woman with 8.4 weeks estimated gestational age with last menstrual period revealed following reports on transvaginal ultra-sonography:
1. Bulky uterus
2. Single gestation sac of about 5.43X4.62X3.34 cm size in uterine cavity.
3. Crown to rump length of embryo is 16.3 mm which correspond to 8.2 weeks of gestation.
4. Normal yolk sac seen in gestation sac.
5. Trophoblastic rim is normal in thickness and ecogenicity. A small anechoic area seen right laterally.
6. Gestation sac contains single embroyo without cardiac pulsations.
Pathology impression: finding suggstive of missed abortion. Minimal separation of membranes noted.
Physician recommend to undergo D&C (dilation and curettage). What would be the actual action to be taken under such circumstances i.e.  D&C or wait for few weeks. Is such kind of sonography reports are always true.
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While waiting and re-scanning is probably safe, it is also unnecessary. Given the advanced size of the foetus, the lack of heartbeat is inconsistent with normal pregnancy and is diagnostic of nonviable pregnancy (missed abortion)
Diagnostic criteria for nonviable pregnancy early in the first trimester.  N Engl J Med. 2013 Oct 10;369(15):1443-51.
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Which cell type are the cells in the lumen of an endometriosis lesion?
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Endometrial epithelial cells and stromal are most common cell types in endometriosis
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miRNAs used:  mimics for both 125b and let7B (will work with inhibitors also since this is a product of an endometriosis paper done previously)
transfection reagent: RNAimax
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If you want to detect the alterations in the cytokine abundance I would suggest to perform an Elisa or Elisplot with your treated macrophages. This would be the best way to see if your treatment has a functional consequence on them.
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have read about bioactive peptides in food with potential health benefits and much research in this area but also have seen references to a RICE peptide=RGD--that has embryotoxicity at least in lab animals. This RGD is described as a LAMININ-like peptide involved in immune mediated reproductive failure. I am also aware of reports of anti-LAMININ antibodies found in women with endometriosis and infertility. Is there any evidence of this RGD embryotoxicity in humans, or any cross reactivity beween the RICE RGD and HUMAN LAMININ---I am totally unaware of any dietary implications related to RICE on pregnancy---any data at all in this context?
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The value of physiologically and biologically active motifs present in proteins
is considered critically taking into attention many aspects including the mechanisms
of action of the peptide in a body, the processes of protein hydrolysis and the inhibition of them during enzymatic digestion, the absorption of peptides into a bloodstream, the length and a structure of the peptide. Although the enormous growth on studies concerning the structure and the activity of the motives had been observed, some mechanisms of bioactivities of peptides are still not fully discovered. However, the information concerning the function and structure of bioactive proteins and peptides gathered in the various database resources interconnected with the mathematical descriptions of the biological phenomena is a powerful tool to assign the protein to a group of more potent biomacromolecules. BIOPEP is one of the tools which contributes to such approach.
The strategy of analysis of proteins as the precursors of bioactive peptides involving
BIOPEP procedure enables to classify proteins to be a rich/poor source of motifs with biological and physiological functions..This approach can be successfully
applied to introduce nutraceuticals as the valuable source of peptides with biological
activities.
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I am especially searching for psychological and/or cultural causes of endometriosis. Thank you for your answers!
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I don't think there are such causes. However, cultural and psychological causes influence the quality of life related to health and the perception of health in women with endometriosis. 
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I need two cell lines to perform a study in endometriosis and normal endometrium but which kind of cell lines are more suitable to perform this kind of study? 
thank you in advance!!
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Met5a mesothelial cell line might be worth trying to look at interaction between endometrial and mesothelial cells.
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Besides abdominal pain, subfertility is the second key symptom in patients suffering from endometriosis. Details of the model I am searchng for a described in the attached flyer.
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I am very interested in such a study. Currently I coordintate the Endometriosis team at the Federal University of Minas Gerais in Brazil. In addiiton to the public service I also work with a muldiscplinary team at the private sector. We have some research on the area but the questions of subfertility in Endometriosis remain ellusive. Patients are heterogeneous and many times other causes of infertility (eg Male factor) are found.I will be more than happy to contribute to your research.
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Infertile patients and Endometriosis III or IV seen for the first time.
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Natural Ivf is a low cost effective primary treatment for endometriosis for infertile patients
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We at the Endometriosis Association are beginning another capital campaign to fund research as we've done throughout our 35 year history (over $29 million direct & indirect so far).  We're pondering how best to prioritize research aims and are interested in feedback from the research community.
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Answer: Finding out how endometrial tissue spreads, as the blood vascular and lymphatic vessels do not explain its pattern of spread.   This must be by an unrecognised anatomical pathway from the bottom to the top of the body.  The same route is involved by vicarious menstruation, and many other substances which end up in unusual places, eg urine and bile in the ear canal.   The vital clue to this pathway is the intense pain that originates when substances pass up it.   In the first instance, little money would be needed, just a thorough review of all the literature, old and new.  
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Either positively or negatively associated factors.
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  1. dear   victor C .Kok
  2. positively associated factors
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Endometrium is estrogen dependent reproductive tissue.
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Thank you Dr. Safoura, but there is any prescribed therapy for this.
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.
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thanks!
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I am struggling with subculturing mouse endometrial cells using trypsin/EDTA and a cell scraper. I have no problem isolating the cells, but when they become confluent and they are due to be subcultured, they stop growing and die following trypsinisation/scraping.
Can anyone suggest any alternative method I could use to successfully lift off the cells and seed them into a new flask?
Thanks
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Well Matthew I guess we have cracked it!!!!
The new medium we have tried (SensiCell DEMEM/F12) worked quite well. We have managed so far to do 2 passages.
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Endometriosis needs to be addressed with proper therapeutic molecules. Biosimilars are probably the answer. What phytochemicals are promising in this effort?
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LHRH Analogue called NAferelin acetate has widely been accepted USFDA aaproved drug other than any biosimilar. It is modified nine-mer synthetic peptide. I am not aware of any phytochemical for the same.
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Levels of cytokines/chemokines can vary depending on the time of day the blood sample is collected, stress level of the patient and how the blood was collected. Accounting for these factors is important in my opinion. Also, why aren't Il-10 and IL-12 results also reported as a ratio to give a better indication of the immune status in endometriosis?
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Yes! Most inflammatory traumas trouble during night hours. May also relate to BMR during activity and sleep. Promising proposal.
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Dear colleagues,
I need help because I have recieved a 39 years old patient who had been submitted to Abdominal Hysterectomy for endometriosis in January, 2013 but she maintains abdominal-pelvic pain chart and to make worse all that, she has Lupus so I have doubts concerning what might be the best approach for the case and if is posible to use progesterone for her. I think it is not a surgical case because there is no identified focus at MR.
Thanks for your help
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I am a scientist with rare autoimmune condition not that dissimilar to lupus. I manage my own condition under the guidance of my doctors as not much is know about my condition. I also went through difficult endometriosis surgery which dramatically improved pain but did not eliminate it. Based on my knowledge and experience, I agree with JAir and vasculitis would certainly be one thing to consider. It will not be welcomed from a doctor but based on my experience learning to live with the pain makes it more manageable.
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What are the genes related to etiology of endometriosis?
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Hi Priyanka, endometriosis is a largely multi-factoral conditions involving the disregulation of many genes and molecular pathways, however here are some papers that I think will definately be of use to you http://www.ncbi.nlm.nih.gov/pubmed/21193803 http://www.ncbi.nlm.nih.gov/pubmed/20104428 http://www.ncbi.nlm.nih.gov/pubmed/16816328 http://www.ncbi.nlm.nih.gov/pubmed/23006437 http://www.ncbi.nlm.nih.gov/pubmed/22556377 http://www.ncbi.nlm.nih.gov/pubmed/22203846
Best Regards
Matt
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Can anyone share an aliquot of immortalized endometrial stromal and epithelial cells (not from cancers like the ISHIKAWA cells)? I also need cells from ectopic endometrium. I am willing to sign the MTA and the necessary formalities, it's quite urgent.
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