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Emergency Toxicology - Science topic

Drug interactions and new poisonings
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Publications related to Emergency Toxicology (36)
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Although warfarin overdose is a frequent side effect, suficidal intakes are rare but warfarin overdose is an expected end in these cases. In these cases, international normalized ratio (INR) can be seen high for a long time. In the case of warfarin overdose, vitamin K is sufficient to reverse the effect, but this is not sufficient for suicidal inta...
Presentation
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Method of Diagnosis of Acute Radiation Syndromes based on ELISA kit - Human Membrane Radiation Induced Membrane Attack Complex - HMRIC. HMRIC is a ready-to-use paper-based ELISA or micro well, strip plate ELISA (enzyme-linked immunosorbent Assay). HMRIC – ELISA kit target MAC in biological samples and analysing MAC levels in biological samples such...
Article
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Emergency toxicology: Timely antidotes and giving poisoned organs a second life – CORRIGENDUM - Sophie Gosselin
Conference Paper
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HICHAM N, ABKARI A, BENTAFRIT M, EL BOUAZZI O, ZALAGH F, SOULAYMANI A, BADRANE N, SOULAYMANI BENCHEIKH R Objectif : Les dosages en toxicologie d’urgence revêtent un intérêt dans la confirmation de l’intoxication, l’évaluation de sa gravité et l’orientation du médecin dans sa prise en charge. L’objectif de cette étude était de décrire l’expérience...
Article
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Para o adequado diagnóstico e tratamento no pronto-socorro, muitas vezes é necessário saber se a condição de um paciente pode ser elucidada pela intoxicação com algum agente tóxico. Assim, a análise toxicológica é normalmente conduzida quando o paciente apresenta-se sintomático, com histórico de ingestão de determinada substância ou quando a equipe...
Poster
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The importance of early evaluation of home-based pharmacological treatment in A&E. OBJECTIVE: Demonstrate the importance of early evaluation of home-based treatment of patients that come to A&E, to ensure that the symptoms are not due to adverse effects of any medicines taken or pharmacokinetic/pharmacodynamic interactions in patients undergoing mu...
Book
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L’intérêt nouveau pour les remèdes naturels engendre un retour en force du végétal, mais on a parfois oublié que la nature, grande pourvoyeuse d’aliments et de remèdes, constitue aussi un réservoir redoutable de poisons. Ainsi, les services hospitaliers de réanimation enregistrent-ils chaque année des centaines de cas d’intoxications, parfois morte...
Article
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Saliva is a body fluid which, like serum, can be used for determination of concentrations of certain drugs, both in pharmacotherapy as well as in acute poisonings. The aim of this study was to determine carbamazepine concentrations in both saliva and serum in acute poisoning in order to show if there is a correlation between the obtained values, as...
Article
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Objective: to comparatively assess the intensity of oxidative stress (OS) in acute poisonings by various toxic chemicals. Subjects and methods. Two hundred and eighty-seven patients with acute poisoning by psychopharmacological agents, ethanol, and cauterants were examined. Results. A correlation was found between the manifestations of OS and the s...
Article
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Introduction: Intoxication by Tricyclic Antidepressants (TCA) is a frequent diagnosis in emergency rooms worldwide. Liquid chromatography/Mass Spectrometry (LC/MS) and high performance liquid chromatography (HPLC) can provide specific identification of TCA. However, both LC/MS and HPLC are used infrequently in emergency rooms to screen TCA intoxica...
Article
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Résumé L’objectif de la base de données Botanicus & Phytotox est double: - Botanicus regroupe et identifie plus de 279 plantes toxiques avec des équivalents de 2294 noms communs français, arabe et amazigh. Phytotox permet d’évaluer le risque toxique de 120 plantes rencontrées en région méditerranéenne. Cette base de données est destinée principalem...
Article
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In France, basic medical emergency services are mainly provided by public hospitals (88% for the year 2001). The way emergency cases are managed is regulated by various official governmental decrees or memoranda. Emergency units are organized into three different emergency units: Admissions and Emergency Care (SAU), whether a Local Admissions Unit,...
Article
Full-text available
Drugs and chemicals are almost easily available in Iran. Natural toxins as poisonous plants and animals also exist in most parts of the country. Therefore, acute poisonings, either intentional or accidental and also drug abuse/addiction are common in Iran. In spite of these difficulties there is no center for poison control and surveillance in this...
Poster
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OBJECTIF : Les laboratoires de toxicologie d’urgence doivent s’assurer de l’absence d’interférence du Digidot® (fragments Fab antidigitaliques) sur leur technique de dosage de la digoxine (1, 2). Le Dimension® RxL est un automate multiparamétrique récent qui réalise l’immunodosage de la digoxine en phase hétérogène. Jusqu’à présent, le comportement...
Conference Paper
Full-text available
National Taiwan University Hospital has a capacity of 2000 beds, located in an international metropolis of 3 million people. From April 94 to March 95,we used REMEDi HS to analyze 501 emergency patient samples (39.7% serum, 59.9% urine, and 0.4% gastric fluid). Seventy five different drugs were detected and 65.9% of patient samples were found to co...
Article
Aim/Objective Quantification of 70 emergency toxicology (ET) relevant analytes in human blood plasma using the Bruker Daltonik Toxtyper (TT) system. Rapid and comprehensive qualitative and quantitative methods are crucial in 24/7 ET to support the diagnosis and treatment of acute intoxications. This includes estimating their course and monitoring t...
Article
Introduction Le dosage enzymatique de l’éthanol représente un examen de première ligne pour nombre de laboratoires de toxicologie d’urgence. Les caractéristiques analytiques des kits enzymatiques commercialisés en France sont bien connues, mais quelques interférences à maîtriser peuvent toutefois en entacher le rendu. Observation Un bilan toxicolo...
Article
Emergency toxicology: Timely antidotes and giving poisoned organs a second life - Volume 21 Issue 1 - Sophie Gosselin
Article
Objectif Mettre en place et evaluer une methode de criblage large par spectrometrie de masse haute resolution et extraction en ligne des echantillons, utilisable en routine dans un laboratoire de toxicologie d’urgence. Methodes La methode analytique utilise un Orbitrap QExactive Focus® avec extraction Turboflow®. La partie LC-MS-HR a ete decrite pa...
Article
Ein 24-jähriger Mann wurde während des Fütterns seiner Schwarzen Mamba in den rechten Zeigefinger gebissen. Die primären Symptome zeigten das Bild einer Giftexposition, und somit bestand eine lebensbedrohliche Situation. Durch die Organisationskette der präklinischen Einsatzkräfte und das unverzügliche Bereitstellen des lebenswichtigen Antiserums k...
Article
Screening for cyclic antidepressants compounds is a classical toxicology test. Immunological tests are badly known, especially concerning their sensivity and interferences. To investigate which molecules could produce false positive results for cyclic antidepressants screening, we tried to obtain correlations between the test reaction and the three...
Article
This article discusses current strategies for efficient analytical diagnostics in clinical toxicology. The tasks for such diagnostics, different analytical strategies and various methods were reviewed. They cover mainly gas chromatography-mass spectrometry and liquid chromatography-mass spectrometry procedures for target or comprehensive screening...
Article
To date, immunoassays are commercially available for quantification of valproic acid, salicylic acid, paracetamol, phenobarbital, phenytoin, and primidone. As they are no longer available, a fast, simple, and cost-effective quantitative gas chromatography-mass spectrometry (GC-MS) method was developed and fully validated for these drugs. After simp...
Article
Capillary-zone electrophoresis (CZE) has been investigated for urgent toxicological screening of serum of poisoned patients. Samples (115) have been analyzed in parallel with the liquid chromatograph (LC)-ultraviolet (UV)-Remedi (BioradTM) system. This study highlighted the advantages and the disadvantages of this method compared to the LC-UV-Remed...
Article
Acute poisoning is a medical emergency situation and requires urgent but adequate medical intervention. The outcome depends on accurate primary care, the correct identification of poison(s) and adequate therapeutic decisions. The present paper reviews the literature concerning the role of analytical toxicology in emergency medicine with particular...
Article
Drugs and chemicals are almost easily available in Iran. Natural toxins as poisonous plants and animals also exist in most parts of the country. Therefore, acute poisonings, either intentional or accidental and also drug abuse/addiction are common in Iran. In spite of these difficulties there is no center for poison control and surveillance in this...
Article
Many acutely poisoned patients are treated with no laboratory help other than general clinical chemistry and haematology. Emergency toxicological analyses (24-hour availability) that could influence immediate patient management such as iron, lithium and paracetamol (acetaminophen), are relatively few in number and are remarkably similar worldwide....
Article
Une methode originale par HPLC/MS est proposee pour l'identification formelle et le dosage du levetiracetam (LEV ; Keppra®), un nouvel antiepileptique, dans les fluides biologiques. Apres micro-extraction en phase liquide de 100 μl d'echantillon par le chloroforme/2-propanol/n-heptane (25: 10: 65, v/v) a pH 9,5 en utilisant le prazepam comme standa...
Article
Meprobamate is the file leader of carbamates and is still very used in France as anxiolytic agent. It is implicated in about 5 % of over-dosages due to psychotropic drugs. The intoxications are often serious and sometimes fatal with acute circulatory failure. For all these reasons, reliable identification and quantitation of this drug in biological...
Article
La Toxicologie d'urgence associe la notion d'exploration d'un tres vaste domaine de substances chimiques a la notion d'efficacite de prise en charge therapeutique du sujet intoxique. En consequence, la strategie analytique a adopter sera le fruit d'une collaboration clinico-biologique etroite comprenant l'approche clinique (anamnese, signes cliniqu...