Drug Delivery - Science topic

Modern nanotechnologies provide various possibilities for efficiently delivering drugs to biological targets. This review focuses on using functionalized gold nanoparticles (GNPs) as a drug delivery platform. Owing to their exceptional size and surface characteristics, GNPs are a perfect drug delivery vehicle for targeted and selective distribution...

Hollow microspheres with open windows on the shells have shown significant potential in adsorption, catalysis, and drug delivery fields, owing to their low density, large interior volume, high specific surface area, and abundant availability of adsorption sites. However, creating open hollow spheres with structurally stable and entirely organic‐fun...

Photoacoustic imaging is an emerging biomedical imaging technique that enables non-invasive visualization of the optical absorption properties of biological tissues in vivo. Although numerous studies have used contrast agents to achieve high-contrast imaging in deep tissues, targeting specific areas remains a challenge when using agents that are co...

BACKGROUND Spinal muscular atrophy (SMA) is an inherited disease that leads to weakness, loss of ambulation, and progressive scoliosis in many patients, frequently requiring early spinal fusion. Nusinersen is a disease-modifying agent that improves symptoms and slows the progression of SMA but requires serial lumbar punctures for intrathecal drug d...

In recent years, notable advances in nanotechnology‐based drug delivery have emerged. A particularly promising platform in this field is DNA origami‐based nanoparticles, which offer highly programmable surfaces, providing precise control over the nanoscale spacing and stoichiometry of various cargo. These versatile particles are finding diverse app...

Nanoparticle adhesion at liquid interfaces plays an important role in drug delivery, dust removal, the adsorption of aerosols, and controlled self-assembly. However, quantitative measurements of capillary interactions at the nanoscale...

Tumor therapeutic strategies based on mitochondrial damage have become an emerging trend. However, the low drug delivery efficiency caused by lysosomal sequestration and the activation of protective mitochondrial autophagy severely restricts the therapeutic efficacy. Herein, an in situ transformable nanoparticle named KCKT is developed to promote l...

The integration of nanotechnology into cancer treatment has revolutionized chemotherapy, boosted its effectiveness while reduced side effects. Among the various nanotherapeutic approaches, metal–organic frameworks (MOFs) stand out as promising carriers for targeted chemotherapy, with the added benefit of enabling combination therapies. MOFs, compos...

Constant pH Molecular Dynamics (CpHMD) simulations represent a cutting-edge computational approach for studying biological systems with remarkable realism. Recent advancements have enhanced the accessibility and efficiency of CpHMD, significantly reducing the performance overhead compared to traditional constant-protonation MD simulations. This cha...

The significance of Ree-Eyring ternary hybrid nanofluid flow lies in its potential applications in various fields. By incorporating three different types of nanoparticles into a base fluid using the Ree-Eyring model, this innovative fluid offers enhanced thermal conductivity, heat transfer efficiency, and rheological properties. These characteristi...

Pancreatic diseases, typically including pancreatic cancer, pancreatitis, and diabetes, pose enormous threats to people’s lives and health. To date, therapeutics with high therapeutic efficacy and low side effects are still challenging. With the development of nanotechnology, nanomaterials have successfully been applied in pancretic disease treatme...

This comprehensive review goes in depth about the potential of nanotechnology-based drug delivery systems in treating various neurological disorders. It begins with an introduction to nanoparticles, followed by an overview of various neurological disorders that can be treated using nanoparticle-based drug delivery. It also discusses the properties...

Over the past few years, significant progress has been made in DNA origami technology due to the unrivaled self-assembly properties of DNA molecules. As a highly programmable, addressable, and biocompatible nanomaterial, DNA origami has found widespread applications in biomedicine, such as cell scaffold construction, antimicrobial drug delivery, an...

The bioavailability of small-molecule drugs remains a critical challenge in pharmaceutical development, significantly impacting therapeutic efficacy and commercial viability. This review synthesizes recent advances in understanding and overcoming bioavailability limitations, focusing on key physicochemical and biological factors influencing drug ab...

Polysaccharide-based carriers as biomaterials for drug delivery have been inspiring scientists for years due to their exceptional characteristics, such as nontoxicity, biocompatibility, and degradability, as they are able to protect pharmaceutically active molecules and provide their controlled/modified release. This review focuses on selected drug...

Extracellular vesicles (EVs) are membrane vesicles originating from different cells within the brain. The pathophysiological role of EVs in neurodegenerative diseases is progressively acknowledged. This field has advanced from basic biological research to essential clinical significance. The capacity to selectively enrich specific subsets of EVs fr...

The stability of emulsions containing virgin coconut oil-in-water is crucial for their successful use in food, cosmetics, and medicinal products. The goal was to determine the most stable formulation by examining various ratios of VCO, deionised water, and mixed surfactants (methyl-α-D-glucopyranoside combined with either Span 20 or Span 80). This...

Buccal drug delivery emerges as a promising strategy to enhance the absorption of drugs classified under the Biopharmaceutics Classification System (BCS) Class III, characterized by high solubility and low permeability. However, addressing the absorption challenges of BCS Class III drugs necessitates innovative formulation strategies. This review d...

Background: Inhaled drug therapy is an essential treatment in Chronic Obstructive Pulmonary Disease (COPD) patients as it reduces symptoms, exacerbation rate and mortality risk. Errors in inhaler use can affect drug delivery to the lungs and minimize treatment benefits. The aim of the study was to evaluate the effect of a nurse-lead educational int...

Introduction The increasing prevalence of systemic fungal infections, especially among immunocompromised individuals, highlights the need for advancements in targeted and effective antifungal treatments. This study presents a novel nanomaterial, CFW-phosphatidylethanolamine conjugate (CFW-PEc), designed to enhance the delivery and efficacy of antif...

The mechanical, optical, and chemical properties of a wide variety of soft materials are enabled and constrained by their bulk structure. How this structure emerges at small system sizes during self-assembly has been the subject of decades of research, with the aim of designing and controlling material functionality. Despite these efforts, it is st...

The field of peptide based supramolecular biomaterials is fast evolving. These types of constructs have been shown to find applications in the fields of bioimaging, drug delivery and scaffolds for...

Pancreatic cancer, a highly malignant solid tumor of the digestive tract, is characterized by its challenging early detection, rapid metastatic potential, high degree of aggressiveness, and notably low postoperative survival rate. Current therapeutic optionssuch as surgery, chemotherapy, or radiotherapyoften prove inadequate due to the diseases adv...

Background Local drug presentation made possible by drug-eluting depots provides benefits for a vast array of diseases, including cancer, microbial infection, and wound healing. Drug-eluting depots provide sustained drug release of therapeutics directly at disease sites with tunable kinetics, remove the need for drugs to access disease sites from c...

The possibility of precisely regulating and targeting drug release with mesophase or Liquid crystal drug delivery systems has drawn much attention recently. This review offers a thorough investigation of liquid crystal drug delivery systems with an emphasis on their mesogenic architecture. It describes the various liquid crystal forms such as therm...

The mouse‐double‐minute‐2 (MDM2) protein, the main downregulator of the tumor suppressor p53 protein, represents a promising target for the development of novel anticancer therapies. However, the lack of selectivity and poor effectiveness in tumors bearing mutated‐p53 impaired the approval of several MDM2 inhibitors for the market. In this context,...

Polycystic ovary syndrome (PCOS) is the predominant endocrine disorder among women of reproductive age and represents the leading cause of anovulatory infertility, which imposes a considerable health and economic burden. Currently, medications used to treat PCOS can lead to certain adverse reactions, such as affecting fertility and increasing the r...

Targeted drug delivery, also known as excellent drug delivery, may be a therapeutic approach in which a medication is administered more often to one or a small number of body parts than to others. Drug delivery vehicles can provide the medication locally or at regular intervals. Breaking through even the most challenging barriers, like the blood-br...

Parkinson’s disease (PD) is a neurodegenerative disorder that predominantly affects dopaminergic neurons in the substantia nigra and ventral tegmental area, resulting in symptoms such as tremors, muscle rigidity, bradykinesia, and potential cognitive and affective disturbances. The effective delivery of pharmacological agents to the central nervous...

Nanotechnology has significantly advanced various fields, including therapeutic delivery, through the use of nanomaterials as drug carriers. The biocompatibility of ordered porous silica materials makes them promising candidates for drug delivery systems, particularly in the treatment of cancer and other diseases. This review summarizes the use of...

About 1 million of the 6.8 million deaths attributed to disorders of the central nervous system (CNS) each year are caused by neurodegenerative diseases, which include Parkinson's disease, Alzheimer's disease, tumours, and ischaemic stroke. Because of the intricacy of the brain, CNS issues are a major concern. To address issues with toxicity, speci...

Artificial intelligence (AI) is a strong tool that uses anthropomorphic knowledge to solve complicated problems faster. The amazing breakthroughs in artificial intelligence and machine learning mean that the fields of dosage form testing, pharmaceutical formulation, and drug discovery will undergo a major transformation. Researchers can identify di...

Introduction: Central nervous system (CNS) disorders present major therapeutic challenges due to the presence of the blood – brain barrier (BBB) and disease heterogeneity. The BBB impedes most therapeutic agents, which restricts conventional treatments. Focused ultrasound (FUS) -assisted delivery offers a novel solution by temporarily disrupting th...

Multimodal neural interfaces open new opportunities in brain research by enabling more sophisticated and systematic neural circuit dissection. Integrating complementary features across distinct functional domains, these multifunctional neural probes have greatly advanced the interrogation of complex neural circuitry. However, introducing multiple f...

The physical characteristics of the tumor microenvironment (TME) include solid stress, interstitial fluid pressure, tissue stiffness and microarchitecture. Among them, abnormal changes in tissue stiffness hinder drug delivery, inhibit infiltration of immune killer cells to the tumor site, and contribute to tumor resistance to immunotherapy. Therefo...

Protein- and peptide-based medications are recognized for their effectiveness and lower toxicity compared to chemical-based drugs, making them promising therapeutic agents. However, their application has been limited by numerous delivery challenges. Polymeric nanostructures have emerged as effective tools for protein delivery due to their versatili...

Abstract: Based on the existing literature and data, this paper tries to explore the method of building a smart Internet hospital system in Guangxi. By analyzing the literature related to the construction of Internet hospitals in the past five years, collecting and using the literature review method to sort out all types of intelligent services pro...

Plant extracts have been used in the green production of gold nanoparticles (AuNPs), which avoids the use of dangerous chemicals and is both economically and environmentally viable. There is a discussion of different plant sources, extraction methods, and phytochemicals that are involved in the stabilization and reduction processes. The article pre...

In the present work, the encapsulation of Olutasidenib drug as a therapist for leukemia in nanotubes of silicon carbide (SiCNT) and carbon (CNT) as carrier drug is studied using density functional theory(DFT). The encapsulation process has been investigated by analysis of adsorption energy, natural bond orbital (NBO) analysis, density of states, an...

Background Recently, we developed AT101, an IgM-class mouse monoclonal antibody directed against glypican-1 (GPC1), a proteoglycan that can be considered as useful target for glioblastoma multiforme (GBM) treatment being specifically and highly expressed on GBM cell surface. Here, we proposed the use of AT101 as targeting agent in a drug delivery n...

Magnetic small soft-bodied robots are perfect for targeted medication administration, micromanipulation, and minimally invasive surgery because they provide non-invasive access to con ned locations. Presently available magnetically operated small soft robots are based on elastomers (silicone) and uids, such as ferro uid or liquid metal; however, th...

Ceramics have long been recognized for their exceptional properties, ranging from mechanical stability to biocompatibility, making them highly promising candidates for various medical and healthcare innovations. The chapter elucidates the essential processes involved in ceramic synthesis, from precursor selection to material shaping and different h...

Niclosamide, an FDA-approved anti-parasitic drug, has demonstrated significant potential as a repurposed anti-cancer agent due to its ability to interfere with multiple oncogenic pathways. However, its clinical application has been hindered by poor solubility and bioavailability. Lipid-based nanocarrier systems such as liposomes, solid lipid nanopa...

A novel and simple method was used to synthesize antimicrobial and antioxidant porous (N-tert-butylacrylamide-co-N-vinylpyrrolidone) zinc oxide hydrogel via free radical copolymerization. The hydrogel was characterized by NMR, XRD, and SEM. Thermodynamic properties of the hydrogel were described quantitatively by the Flory-Rehner method. The result...

Kidney diseases are characterized by their intricate nature and complexity, posing significant challenges in their treatment and diagnosis. Nanoparticles (NPs), which can be further classified as synthetic and biomimetic NPs, have emerged as promising candidates for treating various diseases. In recent years, the development of engineered nanothera...

The Second Southern Science Conference brought together international researchers focused on health and diseases. The event featured expert lectures across various fields, including cell biology, neurobiology, immunology, and pharmacology. Notable presentations covered new tools for cell biology research, such as the RUSH and RUCH systems, which en...

Pathobiology of the intact human retina has been challenging to study due to its relative inaccessibility and limited sample availability. Thus, there is a great need for new translational models that can maintain human retinal integrity and cytoarchitecture. The role of physiologic intraocular pressure (IOP) and fluid flow on retinal tissue has no...

Multidisciplinary research has been conducted on novel drug delivery technologies to maximize therapeutic advantages while curtailing undesirable reactions. Drugs under BCS Class II often have a low bioavailability because the dissolution phase limits the absorption efficiency. In this review, risperidone was used as a pharmacological model to exam...

Hybrid nanocomposite hydrogels consist of the homogeneous incorporation of nano‐objects in a hydrogel matrix. The latter, whether made of natural or synthetic materials, possesses a microporous, soft structure that makes it an ideal host for a variety of polymer and lipid‐based nano‐objects as well as metal‐ and silica‐based ones. By carefully choo...

Metamaterial absorbers (MMAs) are currently highly desirable because of their special absorption qualities. In this paper, a highly simplified and optimized terahertz MMA is proposed and analyzed for sensing applications. The proposed MMA is polarization-independent because of its symmetrical structure. Its symmetrical structure is achieved through...

Breast cancer is one of the leading causes of death among women, which implies an urgent need to explore further alternative therapeutic strategies than conventional surgery, chemotherapy, and radiotherapy treatments. Thus, prevention should be highlighted through early genetic screening, not only among patients with clear risk factors but also amo...

Intelligent magneto-responsive structures are widely used due to their fast response speed and noncontact control. In this study, the peeling behavior of a slender magneto-responsive sheet under the magnetic field's action is investigated experimentally and theoretically. Firstly, two identical magneto-responsive sheets, with the liquid film adhesi...

Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignant tumor globally. Despite advancements in treatment methods, the overall survival rate remains low due to limitations such as poor targeting and low bioavailability, which result in the limited efficacy of traditional drug therapies. Nanomedicine is considered to be a promising st...

Since biochemists and biologists have progressed in understanding the mechanisms involved in living organisms, biological systems have become a source of inspiration for chemists. In this context, the concept of colloidal tectonics, describing the spontaneous formation of colloidal particles or supracolloidal structures in which the building blocks...

Featured Application: The work presents information on the potential for the synthesis of hydro-gels comprising gold nanoparticles coated with itraconazole, together with an evaluation of their potential utility. Abstract: Gold nanoparticles have been identified as a promising avenue for the development of drug carriers, particularly in the context...

Coacervates have been investigated as protocells or synthetic cells, as well as subcellular compartments for the creation of new materials, thus bridging the gap between living and non‐living systems in materials science, synthetic biology, and bioengineering. Given the design flexibility and simplicity of coacervates, along with the functionality...

Smart microgels (SMGs) and metal nanoparticles (MNPs)-decorated smart microgels have garnered significant attention because of their responsive behavior. Both SMGs and their hybrids are extensively used in adsorption, drug delivery, and catalysis, which can be characterized with expensive instruments. UV-Vis spectroscopy is a technique that can eas...

The bioavailability, release, and stability of pharmaceuticals under physicochemical conditions is the major cause of drug candidates failing during their clinical trials. Therefore, extensive efforts have been invested in the development of novel drug delivery systems that are able to transport drugs to a desired site and improve bioavailability....

Solid lipid nanoparticles (SLNs) have been the most important in the field of nanotechnology these days, which have many enormous advantages, such as non-toxic compounds, high static physical capacity as well, carrying lipophilic drugs, and advantages like controlled drug release and targeted drug delivery with increased stability. Moreover, polyet...