Questions related to Drug Addiction
First I want to start this discussion by thanking you for helping me with this as it is something I have been struggling to figure out.
I picked up this study from a graduate student before and now I am stumped by how to run the data using either SPSS or R (preferably R) or another recommendation. I have attached the data I am working with and as you can see it is divided into three treatment groups: Saline, 10mg/kg, 20mg/kg. By Sex: Male & Female and across three time periods: 12HR, 24HR, 36HR. I was looking at withdrawal scores and in particular certain attributes associated with withdrawal in the rat which is 11 items. What would be the best method to run this data if I want to look for effect of treatment and sex differences on the withdrawal behaviors?
Thank you again.
Socio-cognitive deficits have been associated with certain psychiatric diagnoses such as Schiz, MDD, ASD. However, other strata of the population that show significant Socio-cognitive deficits are problematic substance users. Individuals with any sort of drug addiction or behavioral addictions, such as gambling or gaming disorders have been traditionally treated with motivational enhancement therapies and/or social skills training such as assertiveness training or enhancement of social communication. I'm inquisitive if intervention programs have also included more higher-level skills encompassing Socio-cognitive variables, such as empathy or social perspective-taking. I am looking forward to insights and reflections of mental health practitioners who are working in this area.
It would be so nice if i could get help because i have to prepare one class about how sport helps people with some sort of addiction to any substance and i haven't found much information about it.
I really apreciate any help, thank you.
To evaluate participants with follow up interviews, who completed residential rehabilitation and now currently in the community. The objective is to assess why they relapsed if they did, and what helped them to be abstinent after engaging with a community.
1. Symptoms lead to self-Medication
2. Demographic variables effect on
3. Source of Medicine (Essay Access)
4. Source of Drug Information (Medication knowledge
5. Reasons for self-medications (Motivators)
A common misconception surrounding drug addiction is that it solely affects the life of the user. However, the idea that they aren’t hurting anyone except for themselves is an excuse that many individuals who abuse drugs use in order to justify their addiction. Drug addiction is not a one-person phenomenon, and it creates a domino effect on the lives of those around them. It is a social problem that normalizes drug use and affects individuals and their families.
I am interested in looking at the effect of exercise on treatment of substance abuse. Will the endorphins released during exercise, decrease the need to drink alcohol or take an illicit drug?
My question is simple -
Do you want to help someone ?
Do you want to help change someones life for the better ?
Do you want to have an impact on lowering the suicide rate?
What would you do for someone you love? Anything..
The struggle of addiction and mental health is more prominent today than ever before. With suicide & mental health rates increasing everyday and the lack of information & resources out there required to help tackle and deal with these things are limited.
Granted that there are services out there that do help and do work but are not always easily accessible or in some cases to late. The world is changing and it is becoming more prominent that suicide and mental health are real issues that are being overlooked in some cases where they should not of been.
Change is needed to a better quality of service, information and care that is currently being provided.
Please help us with our research to understand more from holistic overview,
help us to help those that are indeed struggling but are not getting the attention that is required.
Link below is to the study :-
Drug addiction is more prevalent among teenagers.
World drug day celebrated on 26th June bring a sense of awareness to us about this cursed practice.
Parents have to keep watch their children activities
5.6% percent of world population is involved in drung aged between 15-64
Is it possible to measure dopamine level from plasma to observe this association (plasma is stored in -20 degree) ?
I already found articles where higher dopamine concentration is found in Parkinsonism and internet addiction disorder.Is it possible to measure using ELISA kit?
I have implanted bilateral cannula in the nucleus accumbens of adult rat. After one month of implantation, the rat some how removed the cannula along with dental cement. Since we used this rat to study drug addiction, I think this might happen sooner or later. Can I implant the cannula again to the same brain region to this rat after the wound is recovered? or should I sacrifice this rat?
As aripiprazole is a partial D2 agonist, one may hypothesize that it may be an effective agent for the management of psychostimulant-addicted patients. The literature published to date is inconclusive. I am using this in my practice.
I am planning a humble research project about an online group of self help (mutual aid). I would like to know about some serious experience (or bibliographical reference) about this kind of online group. I know how these groups work face to face but not much online. I mean groups for support to other members in certain circumstances. For instance people with no common disorders could get in touch with other patients in the other corner of the world because it is not easy for them the contact face to face (for the distance). Thanks for reading!
Recently, I noticed that Roche company claimed that they have developed a brain shuttle technology which could dramatically (50-fold in animal study) increase the penetration of target proteins (antibodies in their study) into the brain. Although the details of the brain shuttle technology are not published, I think it is not hard to utilize this technology to increase the penetration of other peptides, e.g. opioid peptides, into the brain. A sudden expose of opioid peptides (or combination with other drugs) may lead to short-term euphoria and further addiction. Therefore, I am worried with the help of this technology, the injection of opioid peptides might be much easier than current addictive drugs to cause addiction.
I have seen some promising study results using naltrexone doses of 0.25 to 0.5 mg. daily in conjunction with opioid tapers. I have several patients who are interested to try this, but I fear precipitating withdrawal.
I visited a village where little children were addictive of of gutka since two three years at the age of 6- 10 years.When I have interviewed from his father he said" I also want this he leave this addiction but I failure While I go to my work and return at night I became failure to leave this addiction And No another addictive gutka in my home instead of him Many times I tried to motivated him and insist him to leave this habit even many times I didn't give him pocket money instead of these effort I became fail .His mother is also remain angry with him due this habit". When I little
investigate more than 50 children were addictive of the gutka I amazed how kids became addictive of gutka I tried to motivate them to leave the habit but I think there is more effort needed
to do more and which kinds of steps should be taken ? Dear scholars Which kinds of steps should more steps to get solution from this village and which kind of other steps should be taken......while Many elders are also addictive of gutka and when I discussed the side effects of gutka they said we already aware ....?...A serious problem.....
I'm working with the American Cannabis Nurses Association and would like feedback as to what resources people trust most for evidence based practices for medical cannabis.
I found some studies that look at substance use in pilots who were involved in accidents. What I would like to have are overall numbers, what is the prevalence of substance abuse in pilots specifically or in the airline industry in general.
Any suggestions to credible sources are welcome.
I've heard many stories from women about how pain meds prescribed following childbirth caused a relapse or led to opiate addiction. I couldn't find any research that looked at prevalence or risk factors.
I recently read the meta-analysis and commentary on gabapentin addiction potential by Smith et al in the July edition of Addiction. I was actually quite surprised at the Commentary piece, which suggested that prescribers should avoid dispensing gabapentin to patients with Substance Use Disorders. The mechanism of action of gabapentin is unclear, but it has never been shown to have any euphoric qualities on its own. It has mild sedative qualities and, if overused, causes sedation but not euphoria. The underlying studies in Smith (2016) mostly involved polysubstance use, mostly with opioids and benzodiazepines. I am wondering if anyone, in clinical practice, has any anecdotal evidence of pts using gabapentin (a) to induce euphoria, e.g. not just to induce sleep or sedation and/or (b) to sustain an "Addictive Disorder" as defined by the DSM. From what little I know of the neurophysiology and pharmacokinetics of gabapentin, it is really hard for me to imagine how gabapentin alone would stimulate any sort of euphoria - for example, bind to a Mu receptor, etc. The only possible mechanism I could imagine would be that it up regulates glutamate, but that has been reported only with pregabalin, a much stronger analogue of gabapentin. Any reports from the field?
I'm starting a qualitative study of the processes experienced by families when one of its members use drugs. Attempt to investigate how care and what has connotations in family dynamics and processes of vulnerability / generativity
In the sociology of medicine, but most importantly the research literature on public health and social policy there is a need to emphasize on the topic of drug addiction further than it has already been adavnced
I´m thinking of fentanyl-derivats + methadone or buprenorphine and MDMA, pregabalin + buprenorphin and so on.
The numbers of drug related death are growing again, not only, because of large amounts of relatively cheap heroine, but presumably also because of new psychoactive substances in combination with other drugs and medications. As long as we lean on Immunoassays we even can´t get a solid evaluation on the dimensions of the problem.
I would like to know if there are documented studies on how Addiction (mainly alcohol and drugs) was perceived in the traditional African Society or research on the 'conceptualization of addiction in Africa.
I am looking for any research which has looked at the use of quitlines among youth tobacco users and any research which has looked at the use of NRT among youth tobacco users. I would also be interested in reasons why they might or might not not be effective with youth (e.g., brain biology, etc).
I have been thinking about using Clarity to compare the expression of specific protein before and after addictive drug treatment, to kind of visualizing aberrant plasticity at molecular level. But wondering if the resolution of Clarity would be good enough for this purpose, since the abnormal circuits are the primary reports from the Clarity methodology.
Substance abuse is a patterned consumption of a drug in amounts or with harmful methods Studies shoes that the social support may be helpful to recovery or relapse from it. What is the social support impression on prevention or treatment of it?
Audio verbal hallucination distress multiple drug addict and also withdrawal session .Sometime it give suicidal or homicidal ideas ,which is distressing .Intervention related vocalisation therapy might reduce distress or threats
Information to clarify the Moral Theory in addressing why people use and abuse drugs and other illicit substances. Based on research by Le Moal and Koob 2007
I am searching for research supporting AA 12-step meetings during college years for those diagnosed with substance use disorders.
Sorry, I wasn't being specific enough in my original question (but thanks for your responses so far!). Things like personality and genetics don't really change from day to day, so they can't directly correlate with / predict / cause someone to drink on one day but not another. I'm looking for antecedent causal variables that can fluctuate from day to day, and thereby cause fluctuating behavior from day to day. There are some daily-drinking-diary studies out there on this kind of thing (e.g., daytime experiences of negative social interactions leading to more drinking that evening), and to achieve greater specificity I want to parse "more drinking" into the binary variable "if drank" and the interval variable "how much drank, provided drinking occurred." Different daytime events may be differentially stronger predictors of these two criterion variables, and I'm looking to learn what people know about this possibility. In any research, have these variables been parsed before with respect to the causes of a single drinking episode? Aside from established research, what are your best guesses? Thanks!
I'm aware of the frequency/quantity literature on characterizing global drinking traits, but would like to hone in on what causes whether or not a person will drink on a given day versus how much they will drink on a given day, provided they have at least one drink. Studies on daily determinants of other kinds of potentially problematic behavior or experiential avoidance would also be useful (e.g., drug use, binge eating); I'm primarily interested in functional and methodological approaches to this kind of distinction. Thanks!
There is almost no standardized protocol for weaning away from areca nut. As recent research indicate that areca nut share a nictotinic pathway, use of cytisine or the related compound varenicline could be useful to wean areca nut abusers. Has any body got experience in this?
As our study is looking for someone who overuse their smartphone, and we try to let them experience a period which can reduce their overuse habit.But somehow, less some previours research, don't know 'how long' will much appropriate? what's name of the withdrawal addition process? can this process modified and apply to smartphone users? Wish you can help us , and please provide some evidences and literatures. thanks a lot!!!
I am searching for data on the prevalence of IDU in the USA, by state if possible. Does this exist? So far all I have been able to find is estimates from 1992-2002, and I would say the climate has changed since then.
(Not necessarily looking for heroin use rates, as it can be used without needles and other drugs can be used with needles, etc.)
If you have any leads on this I would greatly appreciate you sharing! Thanks.
I am looking at public policy dealing with child abuse and neglect, specifically the role of DCF in dealing with opiate-dependent parents. What I am wanting to show is that long term abstinence-based recovery is linked to an improvement in socioeconomic status if the treatment is comprehensive. And that recovery improves not only the person and their family, but that recovery helps lift families out of poverty.
many papers about drug addiction and self administration construct experiments involving drug seeking under second order schedule of reinforcement, and as freshman in this field I'd like to know what does that mean . thanks a lot.
Hi all, I need some related studies in regard of "empowering family and community of drug addicts" to be reviewed. I need to know what have been done on this topic and what is needed to be done in the new researches; specifically, researches conducted in Malaysia. Indeed, I need to find the gaps. I have searched for it but I could not find many of them. Only a few ones!
Would you please let me know if you have already done a similar research or have a similar paper in your archives?
Your assistance is greatly appreciated.
I am conducting a cross-cultural analysis using the Standard Cross-Cultural Sample (Murdock y White 2006) in order to elucidate the frequency of the consumption of inebriating plants, mushrooms and drinks in human cultures. I have not been able to find any previous attempts to do this. Does anyone know about such an investigation?
I am a medical postgraduate reasearcher, having a research proposal about epigenetic modification by already existing drugs used in other medical uses in drug addiction
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Cross addiction refers to the presence of two or more addictions - a common trait among addicts. Many cross addicted patients develop secondary dependencies in an effort to deal with their Cross addiction refers to the presence of two or more addictions - a common trait among addicts. Many cross addicted patients develop secondary dependencies in an effort to deal with their primary addiction..
What are the somatic and psychological factors that cause a cross addiction after primary addiction?
I am a candidate masters in advanced psychiatric nursing at the university of the Western Cape, South Africa. My area of interest is substance use disorders as well as psychiatric disorders. My research topic is Psychiatric comorbidity with substance use disorders in adult inpatient treatment centers. I experience difficulty in searching for an appropriate tool to measure this phenomena, especially with the DSM 5 criteria.
Does anyone have any guidance regarding nursing / physician attitudes of patient drug abuse and if attitude or stigmatization of that population can affect patient outcomes?
Dear Colleagues, I am recently working as psychotherapist in a Stationary Clinic for drug-dependent patients. I wonder if you could suggest me Materials, publications or psychoeducative interventions that I could use to prepare group dynamics with my patients. Any suggestion? Thank you very much for your advice!
All the above factors might be involved, although the prevailing factor is drug-drug interactions in drug addicts infected with HIV, namely the following drugs competing with each other at the active center of hepatic CYP3A4: methadone vs NNRTIs, PI vs NNRTIs, epistatins vs NNRTIs, antifungal ketoconazole vs NNRTIs, taxol vs NNRTIs, etc.
Recent have seen individuals with opiate addiction who are presenting ER with severe rhabdo after being clean. They are presenting with negative urine drug screens. Any ideas on what the causative agent(s) might be?
I am interested in any commentaries or research into whether drug addiction (specifically opiates) should be approached medically or criminally. If possible research that focuses on UK or cross country comparisons. Many thanks
I’m researching treatment options for children in foster care who are struggling with drug addiction. I read about Multidimensional Treatment Foster Care (MTFC), Family therapy, multisystem therapy and functional family therapy. I was wondering if anyone knows of Interventions, advice or recommendations for most effective treatments. I’m really looking to find out what you’d consider to be the most efficient method.
I work with self-administration, and, as you know, performing a patency test by injecting methohexital (Brevital) into the catheter is essential. The problem is that this ultrashort- barbiturate is very difficult to find if you don't have a DEA license. Is there a similar compound that can do the same thing? or maybe another technique to verify that the catheter is working? I hope someone can give me suggestions! Thank you!
In France, the prescription of benzodiazepines (BZD ) is a problem . Care for patients with chronic use is difficult. In terms of public health, it is particularly relevant to avoid this situation by prescribing these treatments wisely. A thesis carried out in 2012 resulted in the design of two brief first prescription of BZD guides , one to complaints for anxiety and the other for insomnia.
How would it be possible to assess the relevance of these guides, in actual practice conditions of general practice (GP) , knowing that the conditions of research in MG do not allow a large-scale intervention study ?
I am searching for the efficacy of non-pharmacological methods for methamphetamine dependency.
We are studying the psychopathology of addiction using the SCL-90 questionnaire. We have these questionnaires of heroin / cocaine / alcohol patients. We do need SCL-90 questionnaire of a group of depressed subjects (not addicts). Noone wants to share and collaborate to a paper?
I am interested in substance-induced psychosis, and was wondering if anyone has come across measures of psychosis in this population that can be conducted based on individual recall, i.e. when the person is no longer psychotic.
Has anyone used the BPRS or PANSS in this manner before? Any comments on their utility/validity in this population?
Would appreciate any help anyone can offer.
Something that will closely model human behavior.
I have doubts about using Balb/c mice because they seem to be used as a depressive model. Any suggestions?
There seems to me to be a black hole in the literature regarding Cocaethylene. My research (independently) has suggested a much more prominent awareness of the increased euphoric effects rewarding the addict despite their knowledge of the higher chance of sudden death and/or myocardial infarction within the Cocaine and Alcohol Addicts realm than there is in the Substance Abuse Research data bases or Educational literature... calling for the necessity of further research. Is anyone aware of current research on the consequences or treatment protocols for Cocaethylene addiction?
Methadone maintenance is in the patients perspective a quiet "boring" drug. We think that not only cocaine is often used in high dose maintenance, but also alcohol (carbonic acid + alcohol = "cick"). My question is:
Does anybody know wheher there are combination maintenance programs with fast acting morphine in daytime and low methadone for the night?
I have done a short review of biofeedback and addictions treatment. I have not noticed any current studies that demonstrate the effectiveness of biofeedback therapy in addictions. I am interested as I am a Licensed Clinical Alcohol and Drug Counselor and a MSW candidate.
Please provide links to resources. Thank you.
During drug-addiction studies in rats: We depend on the visual observations and kinetic disturbances in rats for determination of addiction or dependence. What are the additional parameters that can be measured in blood to confirm that rat is being drug-addicted or not?
Methadone is a strong opioid analgesic which was one among the first synthesized substitutes for morphine. It has all morphine-like effects and high habit-forming potential. The modern approach recommends its oral administration only for the strong and intense pains and exclusively to the patients with cancer of different localization and the degree of dissemination. According to the opinion of WHO experts it is justifiable to use as late as stage III of this illness, when the pain still persists despite administration of non-opiate analgesic. The major undesirable effects of heptanon are respiratory and circulatory depression, respiration arrest, shock and cardial arrest. Heptanon was used in the treatment of opiate addiction for heroin withdrawal, not more than 15-21 days. Otherwise, the use of Methadon had produced a new type of a legal, iatrogenic addiction lasting for several months or even for several years. The licit use of this drug as a substitute for the illicit use of heroin has only deepened the already formed dependence. Long-term administration within the Methadon-maintenance programs has turned the addicts into lifelong drug abusers who continued their drug practice with a new opiate addiction. The medicine, and the practice too, have demonstrated that the treatment of Methadon iatrogenic addiction is not any easier than that of the morphine or heroin addiction; there are many who believe that it is even more difficult. For those who still believe in Methadon as a drug of choice for the treatment of drug dependence, there is a question: is the narcotic given by a physician within the treatment program effective enough to help the addict restore to normal living?
I'm currently exploring the literature on older illicit drug users (heroin, cocaine methamphetamine etc) and there seems to be very little on interventions for this particular cohort. While acknowledging the studies and reviews of interventions with older alcohol and prescription drug users, I would be really interested in hearing from people who have carried out therapies, treatments (excluding methadone) with older (45+) clients/patients.
There is a body of literature attesting to the need for a system approach to addiction prevention and treatment. The best example of that is recovery management. I believe that recovery management is currently the best hope for long-term treatment of addiction. Do you feel recovery management is a promising approach to the prevention and treatment of addiction?
Let's say drug X produces a maximum response of 50, so its ED50 is the dose that elicits a response of 25. Drug Y produces a maximum response of 30, so its ED50 is the dose that elicits a response of 15. Isn't comparing these two with statistics like comparing apples and oranges? Yes, you could normalize the maximum response of each to 100, but that seems to be misleading when comparing two drugs. What I really need is a good published reference about the do's and don't of ED50 values, maximum responses, etc. and their analyses, especially in behavioral pharmacology.
I am trying to determine if the use of CNO in drinking water or chow is a reasonable method of delivery for sustained activation of the DREADD receptor.
I am looking to know more about the role nutrition plays in drug addiction/rehabilitation. I have taught nutrition in various drug rehabilitation facilities internationally and I have noticed that the patients are lacking in good nutritional foods that can and will aid the body in healing itself. Thus, my theory is that poor nutrition is keeping drug addicts from reaching true rehabilitation.
There are no studies that focus on any maintenance treatment for stimulants abuse; besides, craving to stimulants remains for many years. For instance, methamphetamine craving remains for many years and this craving could resulting in relapsing; So why there are no evidences about maintenance treatment for stimulants?
I am looking for recommended material to read about drug addiction. Everyone will experience a drug at some point in their lives, whether it be alcohol, caffeine, or chocolate for example. These are social drugs, but some tend to take drug use a step further by experimenting with potentially addictive drugs. I wish to follow an addicts transition from casual use to compulsive use, and also find out why it is so hard to quit.