Doxorubicin - Science topic

Doxorubicin (DOX), a commonly used ant-cancer drug, has its clinical application severely restricted due to its serious cardiotoxic side-effects. Adenylyl cyclase 1 (ADCY1) is recognized for its pivotal role in cardiac pathophysiology. Nonetheless, the involvement of ADCY1 in DOX-induced cardiotoxicity (DIC) remains not well-studied. This study aim...

This study presents PBVT, a polyurethane-based nano-drug delivery system incorporating BINOL (2,2′-binaphthyl-1,1′-diol), tannic acid (TA), and phenylboronic acid (PBA), to overcome critical challenges in cancer therapy such as low drug-loading capacity (DLC), nanoparticle instability, and systemic toxicity. Polyurethane was chosen as the base mate...

Nanotechnology is apprehensive about small‐size nanoparticle (NP) generation using green methodology. Because of the potential biomedical applications of NPs, they are considered the backbone of nanotechnology. The synthesis of NPs via the herbal route is significant over other chemical, physical, etc. methods because the herbal method is simple, n...

Reproductive and testicular toxicity is one of the most important side effects of doxorubicin (DOX), a chemotherapy drug. In our study, we investigated the ameliorative effect of tannic acid (TA), a polyphenol, against DOX-induced testicular and reproductive toxicity in rats. For this purpose, rats divided into four groups (n = 5 each). Rats were t...

Doxorubicin (DOX) is a common drug used in chemotherapy to treat for advanced ovarian cancer, but it can cause organ damage, particularly to the kidneys. This study aimed to investigate whether the SIRT1/HSF1 pathway is associated with DOX-induced nephrotoxicity. Bioinformatics analysis was performed using single-cell RNA sequencing (scRNA-seq) dat...

Citation: Seung, S.J.; Wong, A.; Milan, R.; Chandran, N.; Razak, A.R.A. Epidemiology, Treatment Patterns, Survival, Healthcare Resource Utilization, and Costs of Dedifferentiated Liposarcoma (DDLPS) in Canada: A Retrospective Cohort Study Using Administrative Databases in Ontario. Curr. Oncol. 2025, 32, 273. https://doi. Abstract: Background: Dedif...

This study explores the effectiveness against selected cancer cell lines of nano-engineered formulations composed of inorganic cores with steroid-based polymeric shells functionalized with either a targeting or chemotherapeutic agent. We present the synthesis and comprehensive characterization of iron oxide nanoparticles coated by polymeric layers...

The advent of nanosensing technologies marks a significant advancement in medicinal chemistry, particularly in the detection and monitoring of therapeutic agents such as doxorubicin. This review aims to elucidate the development of cutting-edge biosensor technologies specifically tailored for the sensitive and selective detection of doxorubicin, a...

Cardiac organoids provide an in vitro platform for studying heart disease mechanisms and drug responses. However, a major limitation is the immaturity of cardiomyocytes, restricting their ability to mimic adult cardiac physiology. Additionally, the inadequacy of commonly used extracellular matrices (ECM), which fail to replicate the biochemical and...

Objective To investigate the mechanism by which resveratrol (Res) ameliorates cognitive impairment (CI) in chronic kidney disease (CKD) rats through modulation of gut microbiota and suppression of inflammation. Methods A CKD model was established in rats via two intravenous injections of doxorubicin (4 mg/kg, 2 weeks apart). After 8 weeks, renal f...

Based on the rational design of DNA intercalators and Topo-II inhibitors and taking into consideration the main pharmacophoric features of doxorubicin (Dox) as a reference standard, we theoretically designed novel substituted tetrahydropyrimidine analogues (T1–35). The designed analogues (T1–35) were investigated for their inhibitory potential towa...

Cancer is a significant global disease with high mortality and limited therapeutic options. Chemotherapy is a cancer treatment option; however, there are still issues, including severe side effects, inadequate response, and drug resistance. Abietic acid is a natural diterpene with diverse pharmacological properties and can be used for cancer treatm...

Background: Micro-oxygen therapy can reduce the effects of doxorubicin (DOX) on left ventricular function, cardiac fibrosis, inflammation, and oxidative stress in SD rats. These results suggest the potential of DOX for clinical use. Method: 8-week-old SPF-grade SD male rats were randomly divided into four groups: control group (Ctrl) (n = 10), doxo...

دوكسوروبيسين هو دواء فعال للغاية مضاد للسرطان واسع النطاق، ومع ذلك فإن تطبيقه السريري مقيد بسبب آثاره الجانبية الخطيرة التي تشمل السمية الكبدية. الإريثروبويتين، وهو هرمون بروتين سكري معروف في الأصل بدوره الهام في تحفيز تكون كريات الدم الحمر، تبين مؤخرًا أن له تأثيرات وقائية خلوية كبيرة في الأنسجة المختلفة، بما في ذلك الكبد والقلب والدماغ. كان الغرض...

Significant progress has been achieved in cancer treatment with Doxorubicin (DOX), yet its low toxicity and poor bioavailability have long troubled scientists. Dodecylphosphorylcholine (DPC), as a candidate material for drug delivery systems (DDS), holds promise in assisting DOX to overcome its application bottleneck. In this study, employing a com...

The treatment of osteosarcoma remains challenging due to limitations of chemotherapy. Anticancer peptides present a promising avenue as alternative therapeutic agents; however, they encounter significant drawbacks, including susceptibility to proteolytic degradation and constrained selectivity toward tumor. Herein, a few‐shot peptide screening stra...

Background 8MW0511 is a novel, long-acting recombinant human granulocyte-colony stimulating factor (G-CSF) produced by the fusion of the N-terminus of highly active modified G-CSF with the C-terminus of human serum albumin (HSA). Current G-CSF treatments require frequent administration and have limitations in efficacy and convenience, highlighting...

Background: The efficacy of doxorubicin (DOX) in treating numerous solid tumors has been restricted, especially due to its most serious side effect: Cardiotoxicity. Little research has been conducted on the protective benefits of high-intensity interval training (HIIT) against the cardiotoxicity caused by DOX (CTD). Objectives: The study aimed to e...

P‐glycoprotein (P‐gp) functions as a critical membrane transporter that drives tumor resistance by mediating drug efflux, ultimately contributing to multidrug resistance (MDR). Recently potent inhibitors have shown significant potential in countering chemotherapeutic resistance, particularly in breast cancer. However, P‐gp's presence in essential o...

Anthracycline anti-cancer drugs, which are used in cancer chemotherapy, frequently cause cardiotoxicity, the incidence of which depends on cumulative doses. TXB-001 is a new candidate polymer-conjugated pirarubicin (THP) with higher THP purity and content compared to previous P-THP (polymerized THP) and is expected to exhibit lower cardiotoxicity a...

BEN domain-containing protein 4 (BEND4) is implicated in various cancer-related processes, but its role in diffuse large B-cell lymphoma (DLBCL) remains unclear. This study examined BEND4’s impact on DLBCL prognosis through bioinformatics analysis. BEND4 expression was analyzed across the cancer cell line encyclopedia (CCLE), human protein atlas (H...

Osteosarcoma is a highly aggressive malignant bone tumor characterized by an immunosuppressive microenvironment, with the five-year survival rate of metastatic patients remains dismally low. Oncolytic virotherapy has emerged as a promising strategy, utilizing both direct tumor lysis and immunity activation. This review systematically examines the l...

To address the challenges of limited drug accumulation and penetration in pancreatic ductal adenocarcinoma (PDAC), a cascade ultrasonic cavitation strategy designed to enhance drug delivery by sequentially overcoming biological barriers is developed. This approach employs a macrophage membrane‐modified microbubble–nanoparticle hybrid (MMB@TFHPD) ca...

Nicotinamide riboside (NR) a NAD+ precursor. There is ample evidence in the literature for beneficial effects of its peroral administration in cardiovascular, neurodegenerative, renal, hepatic, and some other diseases. Previously, we have advanced a hypothesis that intravenous NR administration exerts a cardioprotective effect during doxorubicin an...

Conventional chemotherapy remains a fundamental strategy for cancer treatment but is often limited by systemic toxicity. To address this challenge, Mix Gel is developed as a hybrid hydrogel combining the biocompatibility of decellularized omentum hydrogel and the mechanical stability of sodium alginate. Peritumoral injection of Mix Gel effectively...

The long-term effects of doxorubicin (DOX) chemotherapy on thymic immune function in childhood cancer survivors remain inadequately understood. This study explores the immediate and delayed impacts of low-dose DOX on thymic immune populations using a juvenile mouse model. Male mice received intraperitoneal DOX injections (4 mg/kg/week) for three we...

Anaplastic large cell lymphoma (ALCL) is an aggressive peripheral T-cell non-Hodgkin lymphoma. Breast implant-associated ALCL is a rare subtype of ALCL, now designated as a separate entity under the latest 5th edition of the World Health Organization classification of hematolymphoid tumors. ALCL of the breast in a patient without a breast implant i...

Background Dexrazoxane, a putative iron chelator, is effective in preventing doxorubicin-induced cardiotoxicity. However, dexrazoxane is also a catalytic inhibitor of topoisomerase 2b (Top2b), a key mediator of doxorubicin toxicity. Preclinical studies have shown that dexrazoxane induces Top2b degradation, and early administration (8 h before doxor...

Background Canine hemangiosarcoma is a common and aggressive vascular malignancy predominantly affecting dogs over six years of age. Despite surgical resection followed by adjuvant chemotherapy, median survival remains around 4–6 months. Propranolol, a beta-adrenergic receptor (b-AR) antagonist, has shown efficacy in human angiosarcoma, a tumor wit...

Small materials with pliability and untethered mobility are particularly suitable for minimally invasive medical interventions inside the body. However, the capabilities and applicability of such soft ‘robots’ are restricted by foreign-body responses to them and by the need to get them cleared from the body after the intervention. Here we report th...

This work aimed to develop Doxorubicin (DOX), D‑alpha‑tocopheryl polyethylene glycol 1000 succinate (TPGS), and hyaluronic acid (HA) liposomal delivery system using the Quality by Design (QbD) methodology. Developed liposomal formulations show sustained release behaviour as compared to free DOX (96.7 ± 1.81% release in 12 h), as indicated by the re...

INTRODUCTION: Primary cardiac tumors are rare, with malignant myxofibrosarcoma cases being particularly uncommon, while cardiac myxoma is a common diagnosis in clinical practice. We present a case of cardiac myxofibrosarcoma, whose clinical course was quite unusual. CASE PRESENTATION: A 67-year-old woman with no prior history of cardiac tumors was...

Solitary fibrous tumor (SFT) is a rare fibroblastic mesenchymal neoplasm with a low metastatic potential. The parapharyngeal area in the head and neck is one of the rarest subsites. Surgical excision remains the standard of care. The local recurrence rate stands at 4%, while the distant recurrence rate is 7% over a 5-year period. Radiation can be u...

Feline colorectal adenocarcinoma (FCC) is a locally invasive, highly metastatic malignant gastrointestinal tumor of colon or rectal mucosa in cats. When detected early, surgical resection may provide a promising prognosis. However, no clinical symptoms are observed in the early stages, and distant metastases or peritoneal dissemination are often al...

The Journal retracts the article “Nanoformulated Ajwa (Phoenix Dactylifera) Bioactive Compounds Improve the Safety of Doxorubicin without Compromising Its Anticancer Efficacy in Breast Cancer” [...]

Breast cancer, one of the leading causes of cancer-associated deaths, is responsible for the majority of cases of cancer in women globally. Traditional therapies used for the treatment of cancer have some challenges such as low cellular absorption, multidrug resistance, and limited bioavailability. Current innovations in nanotechnology, such as nan...

Objective: Systemic anaplastic large cell lymphoma (sALCL) is a rare and severe non-Hodgkin lymphoma. Despiteits clinical relevance, the aetiology of this disease is unknown, not allowing the patient to prevent and counteractit. This study investigates the cost-effectiveness of Brentuximab Vedotin (BV) in combination with cyclophosphamide,doxorubic...

In this study, platinum nanoparticles (PtNPs) were synthesized and their potential to improve the efficacy of doxorubicin (DOX) in cancer treatment was investigated. H2PtCl6, LiAlH4, and trisodium citrate were used during the synthesis of PtNPs. They were characterized using dynamic light scattering (DLS), Fourier transform infrared spectroscopy (F...

The development of drug carriers with efficient absorption and controlled delivery properties is crucial for advancing medical treatments. Metal–organic frameworks (MOFs) with tunable porosity and a large surface area represent a promising class of materials for this application. Among them, NUIG4 stands out as a biocompatible MOF that exhibits exc...

Dihydropyrimidinone (DHPM) derivatives are heterocyclic compounds known for a variety of biological activities including anticancer properties. The Mitsunobu reaction was used in this study to synthesize a new DHPM derivative, ethyl 4-(4-isopropoxy-3,5-dimethylphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (compound B2), and asse...

Spelt is gaining popularity due to its nutritional and ecological benefits, particularly in organic farming. Juice from young spelt grass is rich in potassium, phosphorus, manganese, and chromium, along with beneficial pigments and phenolic compounds, all of which support human health. This study examines the phytochemical composition (photopigment...

While advancements have been made in cancer treatment, achieving effective localized therapy remains a significant challenge. Major obstacles include the inefficiency of drug delivery methods and the side effects linked to traditional chemotherapeutics. In this study, we present an innovative delivery system designed to transport doxorubicin (DOX)...

Introduction Drug-induced cardiotoxicity (DICT), defined as myocardial injury caused by direct or indirect toxicity of therapeutic agents, disrupts cardiovascular homeostasis, underscoring the urgent need for preventive strategies in clinical practice. Doxorubicin (DOX), a clinically established anthracycline chemotherapeutic, induces dose-dependen...

In this study, a new system of drug-functionalized graphene quantum dots (GQDs) is presented for combined therapeutic delivery and imaging. To do this, doxorubicin (DOX), which is a strong anticancer reagent, is chosen due to its organic nature. Additionally, to investigate quantum confinement effects on the system's efficiency, diamond-shaped GQDs...

Breast cancer (BC) is the most common type of cancer in women. Researchers have studied various types of inhibitors of the MAPK/ERK signaling pathway, which plays an important role in the growth of BC cells. PD98059 is a potent and selective inhibitor of MEK, which may have potential application in the combined treatment of BC along with doxorubici...

Natural bioactive compounds with anti-neoplastic effects, such as celastrol (CLS), have attracted considerable interest in recent years. The present study aimed to investigate the effect of CLS on wnt/β-catenin signaling, and its potential combination with doxorubicin (Dox) to enhance chemotherapeutic effects. After intramuscular inoculation of Ehr...

Conventional treatments for glioblastoma (GBM) are hindered by systemic toxicity, limited blood–brain barrier penetration, and therapeutic resistance. To address these challenges, we developed dual-functionalized gold nanoparticles (AuNPs) conjugated with a biotinylated NFL-TBS.40-63 peptide and the chemotherapeutic agent doxorubicin. This platform...

Doxorubicin (DOX) or adriamycin is a common anticancer drug with a narrow therapeutic index. Therefore, sensitive and reliable quantification of DOX is crucial for therapeutic drug monitoring purposes. In this study, both a spectrophotometric and a smartphone-based colorimetric method were fabricated to detect DOX in plasma samples. Both methods ut...

GSH biosynthesis is enhanced in cancer cells that express the variant isoform of the surface antigen CD44 (CD44v), which is overexpressed in certain types of cancer. The GSH-responsive prodrug Ns-Dox was prepared by modifying the GSH-responsive group 2-nitrobenzene sulfonyl (Ns) with the model drug doxorubicin (Dox). Its function was evaluated base...

Chemotherapeutic resistance is a major obstacle to chemotherapeutic failure. Cancer cell resistance involves several mechanisms, including epithelial-to-mesenchymal transition (EMT), signaling pathway bypass, drug efflux activation, and impairment of drug entry. P-glycoproteins (P-gp) are an efflux transporter that pumps chemotherapeutic drugs out...

Cellular senescence, a hallmark of aging, reveals context-dependent phenotypes across multiple biological length scales. Despite its mechanistic importance, identifying and characterizing senescence across cell populations is challenging. Using primary dermal fibroblasts, we combined single-cell imaging, machine learning, several induced senescence...

Breast cancer is the most common cancer in women worldwide. Anthracyclines (doxorubicin, epirubicin, daunorubicin, idarubicin) are among the most used drugs for the treatment of breast cancer. Unfortunately, anthracyclines cause cardiotoxicity, which is a limiting factor for its use, and the lifetime cumulative dose of anthracyclines is the major r...

Breast cancer and lung cancer are two of the most prevalent and deadly malignancies worldwide. Both cancers present significant challenges in terms of effective treatment and management, highlighting the urgent need for novel therapeutic strategies that can improve patient outcomes. This study focuses on the synthesis of novel heterocyclic compound...

Doxorubicin (DOX) is an anthracycline antibiotic widely used as an antineoplastic agent. L‐theanine (LTN) is a unique amino acid obtained from tea (Camellia sinensis) and a highly valuable nutraceutical additive in the food industry. The aim of this study was to investigate the effects of LTN on ovarian endoplasmic reticulum stress (ERS) in DOX‐ind...

Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality, driven by tumor heterogeneity, metastasis, and therapeutic resistance. While Rho GTPases are well-established regulators of oncogenic processes, the role of the atypical GTPases in NSCLC remains unexplored. Here, we identified RHOV as one of the commonly upregul...

Older patients with classical Hodgkin lymphoma (cHL) have lower tolerance and inferior outcomes after standard chemotherapy regimens. To identify patient-derived indicators of frailty associated with outcome, we retrospectively analyzed patient and disease characteristics, treatment and outcome in a Norwegian population-based cohort of older (≥60 y...

The blood–brain barrier (BBB) poses a formidable challenge to drug delivery to the brain. One promising approach involves receptor‐mediated transcytosis via Angiopep‐2 peptide (Ang‐2)‐conjugated nanoparticles. However, the influence of Ang‐2 density on BBB penetration remains poorly understood. We developed a versatile polymeric nanoparticle system...

Background Anthracyclines are essential in early breast cancer chemotherapy but pose long-term cardiotoxicity risks. Objectives This study aims to investigate the long-term incidence of cancer therapy-related cardiac dysfunction (CTRCD), bridging with the miRNAs profiler representing acute cardiac injury. Methods We conducted a prospective cohort...

Dihidropirimidinon (DHPM) adalah senyawa heterosiklik dengan inti cincin pirimidin, senyawa ini memiliki berbagai aktivitas biologis. Penelitian ini bertujuan untuk mensintesis senyawa turunan dihidropirimidinon, yaitu etil 4-(4-etoksi-3,5-dimetilfenil)-6-metil-2-okso-1,2,3,4-tetrahidropirimidin-5-karboksilat (A2), melalui reaksi Mitsunobu dan mela...

Background: Soft tissue sarcoma (STS) is a heterogeneous group of rare malignancies with limited response to conventional chemotherapy. Among these, epithelioid haemangioendothelioma (EHE) and angiosarcoma represent rare vascular sarcomas with distinct clinical behaviours, challenging treatment approaches, and poor prognoses. Doxorubicin remains th...

This study aimed to design polyethylene glycol (PEG)ylated chitosan (CS, PEG-CS) nanoparticles for the co-delivery of doxorubicin (DOX), cytosine-phosphate-guanine oligodeoxynucleotide (CpG), and ovalbumin (OVA) to enhance breast cancer therapy. PEG-CS nanoparticles were synthesized using the ionotropic gelation method and characterized for size, z...

Doxorubicin (DOX) is the most widely used chemotherapeutic agent to treat various tumors. DOX treatment can damage many organs, including the brain, by causing oxidative stress. Several antioxidant substances can lessen the effects of DOX or make antioxidant defense systems work faster. Propolis (PROP) is a powerful agent with various healing effec...

Purpose Primary mediastinal large B-cell lymphoma (PMBCL) is a rare subtype of diffuse large B-cell lymphoma. Radiation therapy (RT) has served as the primary treatment option for PMBCL; however, its role has been questioned with the advent of intensified immunochemotherapy. This study aimed to investigate the role of consolidative RT in the primar...

Two major obstacles of nanomedicines in cancer therapy are the limited tumor penetrability and drug‐resistance, especially for those large tumors, severely hampering their therapeutic efficacy for clinical translation. Here, a charge‐convertible degradable silica nanocapsule co‐packaging doxorubicin (DOX) and P‐glycoprotein siRNA (siPgp) (DOX‐siPgp...

Breast cancer is a major health issue among women, and doxorubicin (DOX) is a commonly used treatment. However, its clinical application is limited by its considerable toxicity. This study introduces an acidity-responsive magnetite nanoparticle-based nanocarrier for effective breast cancer treatment. The magnetite nanoparticles were initially coate...

Background : In the KEYNOTE-522 study, a phase III, placebo-controlled trial, stage II-III triple negative breast cancer (TNBC) patients were randomized to receive neoadjuvant pembrolizumab versus placebo, plus paclitaxel and carboplatin for 4 cycles, followed by pembrolizumab versus placebo, plus cyclophosphamide and doxorubicin or epirubicin for...

Small cell lung cancer (SCLC) is a type of high-grade neuroendocrine malignancy with low gene mutation. Chemotherapy is the major treatment strategy, but long-term clinical application often leads to drug resistance. Etoposide is a first-line drug approved by the US Food and Drug Administration for SCLC treatment, but etoposide-resistance is a prob...

Postoperative recurrence of glioblastoma (GBM) is a key contributing factor to the unfavorable prognosis of patients. Chemotherapy has been extensively employed as a postoperative treatment for GBM; however, the produced drug resistance significantly undermines the chemotherapeutic efficacy. Herein, a multifunctional system based on magnesium micro...

Background/Objectives: Our study brings a new method to properly evaluating drug efficacy at the non-invasive in vitro level. Methods: In this work, the electrochemical mediator-free and reagent-free analysis of cell lines based on the registration of electrochemical profiles of membrane proteins was developed. We studied the specificity of cell li...

Objectives: To explore the potential of pyrroline-5-carboxylate reductase 1 (PYCR1) as a pan-cancer biomarker and investigate its expression, function, and clinical significance in bladder cancer (BLCA). Methods: Bioinformatics analysis was conducted to evaluate the associations of PYCR1 with prognosis, immune microenvironment remodeling, tumor mut...

(1) Background: Doxorubicin (DOX) is a frontline chemotherapeutic, but its side-effects from oxidative stress, leading to cardiotoxicity, pose significant challenges to its clinical use. We recently discovered a novel family of proteolysis-resistant, cystine-dense, and cell-penetrating microproteins from Panax ginseng that we term ginsentides. Gins...

Doxorubicin (DOX) is one of the most powerful chemotherapy drugs used to treat different kinds of cancer. However, its usage has been limited by typical side effects and drug resistance, particularly cardiotoxicity. According to studies, a more effective and promising method is to conjugate it or entrap it in biocompatible nanoparticles. Compared t...

Background Chemotherapy combined with angiogenesis inhibition holds great promise in improving the therapeutic efficacy in cancer treatment. The aim of this study was to explore the effect of exosome blockade on tumor angiogenesis and chemotherapy efficacy. Methods Exosomes were extracted by ultracentrifugation, and the effect of exosomes on angio...