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Doppler Ultrasound - Science topic

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I'm trying to evaluate some spectral doppler ultrasound-based algorithms with experimental datasets. But I only found one (a beamformed experimental dataset from the URI toolbox).
link: Insana Lab: Ultrasonic Imaging - The University of Illinois at Urbana-Champaign
Is there any other dataset for spectral doppler ultrasound? If possible, raw data, not beamformed.
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it is nice subject
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Performing pulsed Doppler ultrasound on a single thyroid artery (upper or lower; right or left) is it sufficient for the study of the mean sytolic peak in order to differentiate Graves' disease and Hashimoto's thyroiditis thyrotoxicosis.
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NO!!!! Systolic pulse can be altered in many situation, not only in hyperthyroidism. Hashimoto's thyroiditis is most frequently associated with hypothyroidism, but we must not forget that "hashitoxicosis" does occur too.
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I have a data set and a matlab code to determine the doppler spectrum, however I don't know if it is totally correct.
Can someone help me to apply the formula's given in the picture to the data set to determine the RMS doppler spread, Maximum Doppler shift and mean Doppler spread.
I am stuck for a few weeks with this problem, please help
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Please see attached files. I have used Scilab5.3.3 instead of Matlab. Scilab5.3.3 It is freely downloadable.The equations you can modify/ add and change once you are familiar with the code. I just plotted abs value of the signal.in pdf
Hope you find it useful
Good Luck
Cheers
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In Doppler ultrasonography, be it umbilical artery ultrasound or transcranial Doppler the focus is always on the maximal blood flow velocity, i.e. on the envelope of the spectrogram (see attached Figure). 
Why is this the case and what are the underlying assumptions?  By this I mean, why are we not interested in e.g. the mean flow velocity? I feel the 'maximum' is quite hard to define since the transition region is quite blurry
One assumption, I guess, is that in the insonated vessels such as the middle cerebral artery blood flow is more or less laminar. But still, why the max. velocity?
Thanks a lot!
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Federico,
If you are interested in flow volume, yes, the systolic diameter is the significant one, as most of flow occurs during the systolic phase. Accurate absolute flow volume, however, is rarely of clinical interest: person-to-person variation, as well as the impedance of the vasculature, varies so much that there is no "correct" volume flow like 37C for temperature. What is generally clinically significant are  gross changes, e.g. no flow indicating a blockage, or high flow indicating a hemorrhage, or relative changes, e.g. change in cerebral flow while holding your breath.
Various methods have been proposed for determining the lumen. One method that is appealing to engineers, is to use a narrow beam, and then a beam wide enough to ensure full insonation of the vessel, and look at the difference in backscattered energy at the same distance (so the attenuation is the same); if you know the diameter of the narrow beam, the ratio of the wide to narrow backscatter energy times the diameter of the narrow beam gives the lumen cross-section. (To do this right you must take into account the non-uniformities of the beams, so its not so simple -- or often used.)
See David Evans's publications for real expertise in this and other areas of transcranial Doppler measurements.
Regards,
David
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I am currently looking for edge detection software out there and I have only found 2 companies that offer the software (Quipo and Medical Imaging Applications). If anyone has used either please let me know about your experience and please share any possible suggestions.
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I would defintely recommend you visit www.MIPAR.us.
It is very powerful and intuitive 2D/3D image analysis software written by scientists/end-users and is about to be released as a free trial on December 14th. You can sign up on the site as well as submit images/datasets to test.
There are many image analysis options available, but I think you may just find MIPAR to be something special if you give it a try!
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US-Doppler and thermography come to mind as first options. Is there anything else?
And which would be the easiest laboratory tests to perform on rat blood samples to monitorize inflammatory response?
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You may use X-Ray customed to rats from barintree company for detecting objects noninvasively.
Inflammation has some changes in CBC test which increase the Luekucytes (granulated).
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I am interested to use radar data for hydrological model.
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yes
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My understanding is that angle correction is only required where an absolute value is required e.g. PSV in the MCA but not for a ratio e.g. S/D, PI or RI. Current guidance does not comment on angle correction for uterine artery doppler acquisition.
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Correct! There is no angle guidance.
But AUD should be performed on the booth side it is more than important and recommanded to observe other parameters such umb. art.  and DVPI.
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Estimating cerebral blood flow through big cerebral arteries like ACA, MCA or PCA is achieved by measuring blood flow velocity with ultrasound transcranial Doppler (TCD). Have you used TCD in your neuro-intensive care unit for traumatic brain injury patients on a daily basis? Do you think that we obtain sufficient information from these flow velocity measurements?
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There is not enough evidence (as yet) that TCD is useful or gives us meaningful information. TCD is probably more useful in intra-cerebral haemorrhage but again, not enough information as yet
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I wish to do a Doppler scan of liquid and ferrofluid in a tube. How will it affect the output image in the given cases?
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No difference if they are traveling at the same speed. May be the signal strngth could be different.
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Recent UK guidance advocates use of the ductus venosus in the timing of delivery of the growth restricted fetus. Ductus venosus doppler has a moderate predictive accuracy for determining peri-natal outcome. We are awaiting the official results from TRUFFLE which will hopefully offer further guidance. Additionally many obstetricians are not trained in the acquisition of this doppler and correct acquisition is vital for interpretation and management. Hence, what is the consensus; should we use it? The evidence seems to say so, but what implications does this have for the layout of obstetric care and in reality are obstetricians using it as a tool to time delivery?
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In my opinion DV is not helpfull as isolated Dopplerparameter. The old fashioned idea of an step to step change of UA > MCA > DV seems to be not true (Unterscheider J et al. AJOG 2013 539e1) . There are multiple combinations of changes in the Doppler Parameters and we have to check the follow up of all of them including growth, Amnion Fluid, BPP and the cerebro placental ratio.
DV is sometimes difficult to measure in a IUGR Fetus an there is a risk for a false positive "reversed flow" by measuring the liver vessels. You need training and supervison.
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In the transcranial doppler ultrasound the parameters such as Resistance Index (RI) and Pulsatility Index (IP) reflect the vascular status, I would like to know which one measures the cardiovascular health and cerebrovascular health?
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as far as i remember both can be considerdd as markers of local and global conditions, i caucasic population there is not much difference. In asia this may differ,
Surrogate sonographic markers of atherosclerosis.
Abbas MA, Corea F. Stroke. 2006 Jul;37(7):1644; author reply 1645. Epub 2006 Jun 1.
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I work on blood mimicking fluid and I tried to raise the density of water by dissolving NaCl in it (3.5g/1000g). When I tested it with a Doppler ultrasound device I found quite a nice flow signal. Is it possible that pure solution scatters ultrasound due to some acoustic impedance fluctuation of the solution or maybe it originates from some contamination in the NaCl?
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Jakub:
There is one other example of a change in density of a fluid causing ultrasound echoes on both B-Mode and Color Doppler Modes that I am aware of: ureteral jets. When performing an US of the bladder trigone, jets of urine entering from the ureters can be identified. This effect is even more apparent on color doppler, which is interesting as I believe that the color doppler phenomenon relies on red blood cell movement in relation to the ultrasound probe. Prior studies examining the finding of ureteral jets have theorized that a difference in density between the urine in the ureter and the urine in the bladder is responsible for the US appearance. So my guess regarding what you observed with your experiment was that the NaCl was not contaminated, but rather the interaction between different densities of saline resulted in the ultrasonographic findings.
I hope that helps
Ralph