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Research Proposal
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The combined phenomenon of entrepreneurship with the pursuit of sustainable development goals is commonly referred to as sustainable entrepreneurship (SE) (Shepherd and Patzelt, 2011 ; Anand et al., 2021). As an increasingly important subfield of entrepreneurship research, SE is gaining importance (Muñoz et al., 2018; Gast et al., 2017). However,...
Article
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Open-pit mines are an important source of atmospheric particulate matter (PM) owing to the constant earth-moving and crushing. The well-known association between high PM concentrations and adverse health effects has made the permanent control of fugitive emissions from mines a public health concern. Nevertheless, the large size of these mines rende...
Conference Paper
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Investigating meta-platforms has been a continuing concern within information system literature due to the increasingly complex constellations of platforms in ecologies of ecosystems. A meta-platform is a platform built on top of two or more platforms, hence connecting their respective ecosystems. One promising case to benefit from meta-platforms i...
Article
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Tau accumulation is a terminal event in neurodegenerative disorders, and because the increase of CSF tau in patients with AD occurs closer to the onset of neurodegeneration than does the decrease of Aβ42, tau has been shown to correlate to a greater extent with dementia than Aβ42, with tau aggregates predicting dementia better than Aβ deposits (Oss...
Article
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The discovery of secondary relaxation in metallic glass (MG) breaks the longstanding cognition that MG, as a simple glassy system, exhibits only α relaxation and contributes significantly to the understanding of the structure and mechanical properties of MG. In this work, two independent fast secondary relaxation peaks corresponding to γ and β′ rel...
Article
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Different 2,4-thiazolidinedione-tethered coumarins 5a–b, 10a–n and 11a–d were synthesised and evaluated for their inhibitory action against the cancer-associated hCAs IX and XII, as well as the physiologically dominant hCAs I and II to explore their selectivity. Un-substituted phenyl-bearing coumarins 10a, 10 h, and 2-thienyl/furyl-bearing coumarin...
Article
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Aim:A series of sulphonamide hybrids were designed, synthesised, and identified as potential lysine-specific demethylase 1 (LSD1) inhibitors. Materials and methods: Bladder cancer cell lines were cultured to evaluate the antiproliferative activity. Inhibitory evaluation of sulphonamide hybrids against LSD1 were performed. Conclusion: sulphonamide d...
Article
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Gastric cancer remains a significant health burden worldwide. In continuation of our previous study and development of effective small molecules against gastric cancer, a series of benzochalcone analogues involving heterocyclic molecules were synthesised and biologically evaluated in vitro and in vivo. Among them, the quinolin-6-yl substituted deri...
Article
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Proprotein convertase subtilisin/kexin type 9 (PCSK9) has emerged as a novel therapeutic target for the development of cholesterol-lowering drugs. In the discovery of PCSK9/LDLR (low-density lipoprotein receptor) protein-protein interaction (PPI) impairing small molecules, a total of 47 phenylbenzo[d][1,3] dioxole-based compounds were designed and...
Article
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Despite a huge effort by the scientific community to determine the animal reservoir of SARS-CoV-2, which led to the identification of several SARS-CoV-2-related viruses both in bats and in pangolins, the origin of SARS-CoV-2 is still not clear. Recently, Temmam et al. reported the discovery of bat coronaviruses with a high degree of genome similari...
Article
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T-LAK-cell-originated protein kinase (TOPK), a novel member of the mitogen-activated protein kinase family, is considered an effective therapeutic target for skin inflammation. In this study, a series (A − D) of paeonol derivatives was designed and synthesised using a fragment growing approach, and their anti-inflammatory activities against lipopol...
Article
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Although the therapeutic efficacy and commercial success of monoclonal antibodies (mAbs) are tremendous, the design and discovery of new candidates remain a time and cost-intensive endeavor. In this regard, progress in the generation of data describing antigen binding and developability, computational methodology, and artificial intelligence may pa...
Article
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We construct a difference-in-differences simultaneous equation to study the long-term impact of price limit system on the comprehensive quality of the stock market. Moreover, we use event study method to further test short-term effect. Results show that after the setting of price limit system in China, the quality of total market and the Shenzhen s...
Article
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For blockchain software systems, framework developers may introduce technical debts that application developers are not aware of. Because these technical debts can have a negative impact on software projects, we need to investigate the issue of technical debt in blockchain software systems. We wanted to investigate what types of self-introduced tec...
Article
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A key step in therapeutic and endogenous humoral antibody characterization is identifying the amino acid sequence. So far, this task has been mainly tackled through sequencing of B-cell receptor (BCR) repertoires at the nucleotide level. Mass spectrometry (MS) has emerged as an alternative tool for obtaining sequence information directly at the - m...
Article
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The spatial distribution of heat release rate (HRR) is important for flame front identification. However, direct measurement of HRR is impossible using the current experimental technology. Indirect HRR markers have thus been proposed and used in experiments to approximate the heat release profile. Suitable HRR markers have been identified in previo...
Book
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Phytochemistry, Computational Tools and Databases in Drug Discovery presents the state-of-the-art in computational methods and techniques for drug discovery studies from medicinal plants. Various tools and databases for virtual screening and characterization of plant bioactive compounds and their subsequent predictions on biological targets for the...
Conference Paper
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Numerical simulations are ubiquitous in science and engineering. Machine learning for science investigates how artificial neural architectures can learn from these simulations to speed up scientific discovery and engineering processes. Most of these architectures are trained in a supervised manner. They require tremendous amounts of data from simul...
Article
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Google Play is one of the largest Android phone app markets and it contains both free and paid apps. It provides a variety of categories for every target user who has different needs and purposes. The customer's rate every product based on their experience of apps and based on the average rating the position of an app in these arch varies. Fraudule...
Article
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Behcet's disease is a systemic vasculitis that can manifest as an intracardiac thrombus, which is rare but a serious complication. We report a case of a young male with a history of diabetes mellitus and erythema nodosum, who was admitted for pulmonary embolism associated with a huge serpentine right ventricle thrombus leading to the diagnosis of B...
Article
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Background Databases are fundamental to advance biomedical science. However, most of them are populated and updated with a great deal of human effort. Biomedical Relation Extraction (BioRE) aims to shift this burden to machines. Among its different applications, the discovery of Gene-Disease Associations (GDAs) is one of BioRE most relevant tasks....
Article
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Prognosis of patients with parkinsonism varies greatly between the various parkinsonian syndromes. However, it is often difficult to distinguish the different forms, particularly in early stages. We examined predictors of mortality and functional outcome in patients with recent-onset parkinsonism with an initially uncertain diagnosis ( n = 156). Pa...
Article
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Here we present an intriguing new species of the Empididae genus Rhamphomyia (Pararhamphomyia) from the Kashmir Himalayas. The new species, Rhamphomyia (Pararhamphomyia) aquila, has a distinctive appearance due to its highly deformed male hind legs with extremely shortened hind tibia, a feature very peculiar in the genus. The new species is describ...
Article
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This article examines the challenges and opportunities that arise when engaging with research across disciplines, contributing to the growth of social robotics and artificially intelligent systems. Artificial intelligence has a significant role to play in human–machine communication; however, there are barriers to its adoption and considerations to...
Article
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There is considerable pressure in the pharmaceutical industry to advance better molecules faster. One pervasive concern for protein-based therapeutics is the presence of potential chemical liabilities. We have developed a simple methodology for rapidly de-risking specific chemical concerns in antibody-based molecules using prior knowledge of each i...
Article
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While conventional chemical fungicides directly eliminate pathogens, plant immunity inducers activate or prime plant immunity. In recent years, considerable progress has been made in understanding the mechanisms of immune regulation in plants. The development and application of plant immunity inducers based on the principles of plant immunity repre...
Article
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Calcineurin (CN) controls the immune response by regulating nuclear factor of activated T cells (NFAT). Inhibition of CN function is an effective treatment for immune diseases. The PVIVIT peptide is an artificial peptide based on the NFAT-PxIxIT motif, which exhibits stronger binding to CN. A bioactive peptide (named pep4) that inhibits the CN/NFAT...
Article
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Burkholderia sensu lato bacteria have genomes rich in biosynthetic gene clusters (BGCs) encoding for multiple bioactive specialised metabolites. Diverse classes of antimicrobial natural products have been isolated from Burkholderia, including polyynes, shikimate pathway derivatives, polyketides, non-ribosomal peptides and hybrid polyketide non-ribo...
Article
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Verticillium wilt is one of the most important diseases affecting cotton production in China. The fungus, Verticillium dahliae , has a wide host range and a high degree of genetic variability. No resistance resources have been found in the available planting resources, thus presenting difficulties and challenges for our study. The long-term product...
Article
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A large amount of materials science knowledge is generated and stored as text published in peer-reviewed scientific literature. While recent developments in natural language processing, such as Bidirectional Encoder Representations from Transformers (BERT) models, provide promising information extraction tools, these models may yield suboptimal res...
Article
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Recent experimental findings have reported the presence of unconventional charge orders in the enlarged (2 × 2) unit-cell of kagome metals AV 3 Sb 5 (A = K, Rb, Cs) and hinted towards specific topological signatures. Motivated by these discoveries, we investigate the types of topological phases that can be realized in such kagome superlattices. In...
Article
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span lang="EN-US">Over the past decades, computer networks have experienced an outbreak and with that came severe congestion problems. Congestion is a crucial determinant in the delivery of delay-sensitive applications (voice and video) and the quality of the network. in this paper, the Lagrangian optimization rate, delay, packet loss, and congesti...
Article
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Research integrity, an essential precept of scientific inquiry and discovery, comprises norms such as Rigor, Reproducibility, and Responsibility (the 3R’s). Over the past decades, numerous issues have arisen that challenge the reliability of scientific studies, including irreproducibility crises, lack of good scientific principles, and erroneous co...
Article
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The current nosological concept of α-synucleinopathies characterized by the presence of Lewy bodies (LBs) includes Parkinson’s disease (PD), Parkinson’s disease dementia (PDD), and dementia with Lewy bodies (DLB), for which the term “Lewy body disease” (LBD) has recently been proposed due to their considerable clinical and pathological overlap. How...
Article
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Adjustment for confounding sources of expression variation is an important preprocessing step in large gene expression studies, but the effect of confound adjustment on co-expression network analysis has not been well-characterized. Here, we demonstrate that the choice of confound adjustment method can have a considerable effect on the architecture...
Article
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The aim of this article is to discuss the colour transformations of one of the most representative Gothic façades in Central Europe—the southern façade of Wrocław Town Hall. Based on iconographic, architectural, and stratigraphic research, it was possible to find the remains of two stages of medieval colour changes. Based on these discoveries, an a...
Article
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Symbolic execution is a program analysis technique that aims to automatically identify interesting inputs for an application, using them to generate program executions covering different parts of the code. It is widely used in the context of vulnerability discovery and reverse engineering. In this paper we present SENinja, a symbolic execution plug...
Article
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We reconstruct the genesis of the CPT theorem in quantum field theory from the first proofs of the spin-statistics theorem in 1939/1940 to the discovery of parity violation in 1957. Centrally, we highlight that the original motivation for pursuing the CPT theorem lay primarily in the attempt to identify the correct formulation of time reversal in r...
Article
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It is well established that spatial thinking is central to discovery, learning, and communication in mathematics, as indicated by convincing evidence that those with strong spatial skills also demonstrate advantages for Science, Technology, Engineering and Mathematics (STEM) performance. Yet, spatial thinking—the ability recall, generate, manipulat...
Article
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When identifying differentially expressed genes between two conditions using human population RNA-seq samples, we found a phenomenon by permutation analysis: two popular bioinformatics methods, DESeq2 and edgeR, have unexpectedly high false discovery rates. Expanding the analysis to limma-voom, NOISeq, dearseq, and Wilcoxon rank-sum test, we found...
Article
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A recent discovery of super-Planckian radiation in the far-field has attracted a great deal of interest in thermal radiation control using photonic crystals (PC) architecture. The finding is based on a careful comparison of radiation intensity emitted from a PC nano-filament and a blackbody at the same temperature and same wavelength at λ∼1.7μm. Ex...
Article
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A new generation of community- and population-based research is combining measures of social context, experience, and behavior with direct measures of physiology, gene sequence and function, and health. Studies drawing on models and methods from the social and biological sciences have the potential to illuminate the multilevel mechanisms through wh...
Article
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Background Genome-wide association studies (GWAS) have identified multiple common breast cancer susceptibility variants. Many of these variants have differential associations by estrogen receptor (ER) status, but how these variants relate with other tumor features and intrinsic molecular subtypes is unclear. Methods Among 106,571 invasive breast c...
Conference Paper
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Most of our research effort revolves around uncovering data generating processes (i.e., the how and why phenomena come to be). In this pursuit, we hope that by knowing the how and why, we can discover new knowledge, or perhaps advance our existing knowledge. This short paper presents a look into causal discovery and causal inference from the lens o...
Article
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We review two advances in the development of the Standard Model: the discovery of charm and the evidence for confinement. The discovery of narrow resonances at SPEAR in 1974 inspired theoretical studies of the spectroscopy of charmonium using a confining heavy quark potential. New P-wave charmonium states were predicted and the existence, intensiti...
Article
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Achieving autonomous multi-step synthesis of novel molecular structures in chemical discovery processes is a goal shared by many researchers. In this Comment, we discuss key considerations of what an ideal platform may look like and the apparent state of the art. While most hardware challenges can be overcome with clever engineering, other challeng...
Article
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The tremendous growth in the availability of enormous text data from a variety of sources creates a slew of concerns and obstacles to discovering meaningful information. This advancement of technology in the digital realm has resulted in the dispersion of texts over millions of web sites. Unstructured texts are densely packed with textual informati...
Article
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Since the discovery of the first fast radio burst (FRB) in 2007, and their confirmation as an abundant extragalactic population in 2013, the study of these sources has expanded at an incredible rate. In our 2019 review on the subject, we presented a growing, but still mysterious, population of FRBs—60 unique sources, 2 repeating FRBs, and only 1 id...
Article
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Translational research aims at reducing gaps between fundamental scientific discoveries and real-world applications. However, the trajectory of most scientific discoveries along the translation research continuum remains highly complex. Logic models are powerful tools that can help reduce this complexity. They are often used to lay out road maps an...
Article
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In this paper, we firstly extend the Fourier neural operator (FNO) to discovery the mapping between two infinite-dimensional function spaces, where one is the fractional-order index space {ϵ|ϵ∈(0,1)} in the fractional integrable nonlinear wave equations while another denotes the soliton solution in the spatio-temporal function space. In other words...
Presentation
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Accurate quantum chemical modeling of NMR spectra is deeply involved in the NMR structural assignment of compounds that are currently of utmost importance in both organic and inorganic chemistry. The development of new effective approaches and computational tools capable of providing very accurate NMR chemical shi s and spin-spin coupling constants...
Article
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There is considerable variability in disease progression for patients with amyotrophic lateral sclerosis (ALS) including the age of disease onset, site of disease onset, and survival time. There is growing evidence that short structural variations (SSVs) residing in frequently overlooked genomic regions can contribute to complex disease mechanisms...
Article
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Systematic evolution of ligands by exponential enrichment (SELEX) encompasses a wide variety of high-throughput screening techniques for producing nucleic acid binders to molecular targets through directed evolution. We describe here the design and selection steps for discovery of DNA aptamers with specificity for the two consecutive N-terminal ami...
Article
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The recent discovery of a two-dimensional van der Waals magnet has paved the way for an enhanced understanding of two-dimensional magnetic systems. The development of appropriate heterostructures in this emerging class of materials is required as the next step towards applications. Here, we report on the electrical transport in monolayer graphene c...
Article
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Van der Waals (vdW) heterostructures composed of different two-dimensional (2D) materials offer an easily accessible way to combine properties of individual materials for applications. Owing to the discovery of a set of unanticipated physical phenomena, the twisted 2D vdW heterostructures have gained considerable attention recently. Here, we report...
Article
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The hypothetical Weyl particles in high-energy physics have been discovered in three-dimensional crystals as collective quasiparticle excitations near two-fold degenerate Weyl points. Such momentum-space Weyl particles carry quantised chiral charges, which can be measured by counting the number of Fermi arcs emanating from the corresponding Weyl po...
Conference Paper
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To stay competitive, companies need to continuously improve and evolve their business processes. In this endeavour, business process optimisations and improvements are key elements. In particular , the monitoring of business processes enables the early discovery of problems and errors already during process enactment. Two approaches can be pursued...
Article
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A black hole can launch a powerful relativistic jet after it tidally disrupts a star. If this jet fortuitously aligns with our line of sight, the overall brightness is Doppler boosted by several orders of magnitude. Consequently, such on-axis relativistic tidal disruption events have the potential to unveil cosmological (redshift z > 1) quiescent b...
Article
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Due to different nucleotide preferences at target sites, no single Cas9 is capable of editing all sequences. Thus, this highlights the need to establish a Cas9 repertoire covering all sequences for efficient genome editing. Cas9s with simple protospacer adjacent motif (PAM) requirements are particularly attractive to allow for a wide range of genom...