Science topic
Digestive System Diseases - Science topic
Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).
Publications related to Digestive System Diseases (2,696)
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High Mobility Group Box 1 (HMGB1), a multifunctional non-histone protein, and its involvement in various physiological and pathological contexts has garnered significant attention. Given HMGB1’s central function in modulating key biological activities, such as inflammatory responses and cellular death, its contribution to the pathogenesis of digest...
Digestive and psychiatric disorders tend to co-occur, yet mechanisms remain unclear. Leveraging genetic and transcriptomic data integration, we conduct multi-trait analysis of GWAS (MTAG) and weighted gene co-expression network analysis (WGCNA) to explore shared mechanism between psychiatric and gastrointestinal disorders. Significant genetic corre...
The gastrointestinal tract (GIT), ranging from the mouth to the anus, is a complex system that includes the upper and lower gastrointestinal organs as well as the liver and gallbladder. This system facilitates the entry, absorption, and conversion of nutrients into feces. Structural and functional changes in the organs within this system can lead t...
Biliary duct injury, biliary atresia (BA), biliary tract tumors, primary sclerosing cholangitis (PSC), and other diseases are commonly encountered in clinical practice within the digestive system. To gain a better understanding of the pathogenesis and development of these diseases and explore more effective treatment methods, organoid technology ha...
Background
The entomopathogenic fungus, Isaria fumosorosea, shows promise as a biological control agent in managing the diamondback moth (DBM) Plutella xylostella, a highly destructive global pest of cruciferous vegetables. To date, the miRNA-mRNA regulatory networks underlying the immune response of DBM to I. fumosorosea infection are still poorly...
Lavandula multifida was widely used to treat rheumatism, chills, and digestive system diseases. However, experimental studies supporting these therapeutic properties are lacking. On the other hand, the composition of lavender essential oil is well documented; in contrast, there is less information on the chemical composition of organic extracts. In...
BACKGROUND
Wireless capsule endoscopy (WCE) has become an important noninvasive and portable tool for diagnosing digestive tract diseases and has been propelled by advancements in medical imaging technology. However, the complexity of the digestive tract structure, and the diversity of lesion types, results in different sites and types of lesions d...
n this study, interviews were conducted with 313 informants from the Algerian highlands,
including 47 traditional practitioners, 26 herbalists and 240 inhabitants over two successive years. These
informants cited 121 species, classified into 108 genera and 49 botanical families. The most cited plant
families were Asteraceae (14%) and Lamieaceae (13...
Depression is a heterogeneous and complex psychological syndrome with highly variable manifestations, which poses difficulties for treatment and prognosis. Depression patients are prone to developing various comorbidities, which stem from different pathophysiological mechanisms, remaining largely understudied. The current study focused on identifyi...
Background: The transition from the pediatric to the adult healthcare system is a challenging process involving adolescents, parents, and pediatric and adult specialists. For a successful approach for an organized transition program, we must assess the level of training of adolescents facing transition. Methods: We applied a clinic-based questionna...
Acute pancreatitis (AP), induced by tetracycline, a widely used antibiotic, poses significant clinical and toxicological challenges, yet its molecular mechanisms remain unclear. This study aims to promote drug toxicology strategies for the effective investigation of the putative toxicity and potential molecular mechanisms of antibiotic drugs throug...
Objective
Dual-layer spectral detector CT (DLCT) has several advantages in clinical practice, this study aims to reveal the clinical applications of DLCT in digestive system diseases.
Materials and methods
We searched PubMed and Cochrane Reviews for articles published from January 1, 2010 to May 31, 2024, using the terms “dual-layer spectral detec...
Aldo-keto reductase family 1 member B10 (AKR1B10) is a member of the AKR1B subfamily. It is mainly found in cytoplasm, and it is typically expressed in the stomach and intestines. Given that its expression is low or absent in other tissues, AKR1B10 is a potential diagnostic and therapeutic biomarker for various digestive system diseases. Here, we r...
Objectives
We aimed to explore the characteristics of age, disease and premature mortality among middle-aged inpatients.
Design
Cross-sectional.
Setting
Data were gathered from the electronic medical records system of the hospitals between 2011 and 2020: a regional study.
Participants
A total of 151 320 patients, aged 45–59 years, underwent hosp...
Chronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa’s cascade, CAG is an important pathological stage in the transformation from normal condition to gastric carcinoma. In recent years, the global in...
Traditional Chinese medicine (TCM) has relied on specific combinations of herbs in prescriptions to treat various symptoms and signs for thousands of years. Predicting TCM prescriptions poses a fascinating technical challenge with significant practical implications. However, this task faces limitations due to the scarcity of high-quality clinical d...
Objective
The prison population has been increasing globally, and prisoner health is an important issue of global health. However, it has not received sufficient attention, especially in developing countries and regions. Among all the prisoners, the health status of older prisoners requires special attention due to their declining health and energy...
To demonstrate the potential for connecting metabolomics with traditional Chinese medicine (TCM) external therapies such as acupuncture and moxibustion, we conducted a literature review on metabolomics as a measurement tool for determining the efficacy of various TCM external therapies. Human research and animal models published in the last 10 year...
Background
Pancreatitis is a digestive system disease that imposes a significant burden on society. However, there is a lack of comprehensive research on the incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life years (DALYs) of pancreatitis, as well as on health inequalities a...
Introduction: Digestive system diseases, including IBD, and GERD, are prevalent health concerns worldwide. Physical activity, widely acknowledged for its health benefits, has emerged as a promising area of research for its potential in mitigating symptoms and influencing risk factors associated with digestive system diseases. This study aims to cri...
El trabajo de investigación “Determinantes sociales y salud pública en los usuarios del Hospital Regional Hemilio Valdizán Medrano, Huánuco-2023” tuvo como objetivo general, precisar la influencia de los determinantes sociales en la salud pública de los usuarios del mencionado Hospital Regional Hermilio Valdizán Medrano; en respuesta a la formulaci...
Objectives
Increasing concern about air pollution’s impact on public health underscores the need to understand its effects on non-neoplastic digestive system diseases (NNDSD). This study explores the link between air pollution and NNDSD in China.
Methods
We conducted a national cross-sectional study using 2015 data from the China Health and Retire...
Introduction: Osteoarthritis is a major health concern, and along with coronary heart disease and arterial hypertension, forms a triad of the most common diseases among the adult population. Osteoarthritis significantly reduces the quality of life, leads to disability, and increases mortality rates. Globally, nearly 240 million people suffer from o...
Sensory impairments impact public health both the health and quality of life among middle-aged and older adults. However, in China there is little awareness of the impact of sensory disabilities. In this study, we rates were assessed for isolated visual impairments, isolated hearing impairments, and dual sensory impairments among elderly Chinese fr...
Objective
This study focused on the gastrointestinal (GI) symptoms in the omicron variant infection and the related factors based on digestive health.
Methods
A cross-sectional study was conducted on individuals infected with the omicron variant. A structured questionnaire was developed to gather their demographic characteristics, preexisting dige...
Migrant mortality advantage is established in various studies, but there is a lack of evidence on migrant mortality trends in old age. Previous studies have primarily concentrated on all-cause mortality, and few include older age groups. Discussions about the migrant mortality advantage continue due to concerns about data availability and accuracy....
Introduction: Irritable Bowel Syndrome (IBS) is a common gastrointestinal disorder that significantly affects patient’s quality of life. It is characterized by a complex interplay of physical symptoms and psychological stress, with notable impact on daily function. Cognitive Behavioral Therapy (CBT) has emerged as a promising intervention, targetin...
It is known that Osteoarthritis (OA) is a common chronic disease of the musculoskeletal system, which leads to a significant loss of working capacity and disability of people of working age, which worsens the quality of life of the population and causes economic burden and losses to all countries of the world. In addition, OA is known as a disease...
Clinical features of hypermobile Ehlers–Danlos syndrome (hEDS) and hypermobility syndrome (HMS) have classically focused on dysfunctions related to the musculoskeletal system. A growing body of literature suggests substantial multisystemic involvement, although this has not been recapitulated in a pediatric/young adult population. Leveraging a larg...
The rise of object detection models has brought new breakthroughs to the development of clinical decision support systems. However, in the field of gastrointestinal polyp detection, there are still challenges such as uncertainty in polyp identification and inadequate coping with polyp scale variations. To address these challenges, this paper propos...
Xue Chen Dong Xu Jie Yu- [...]
Yuan-Lu Cui
Background: Tryptophan is widely present in foods such as peanuts, milk, and bananas, playing a crucial role in maintaining metabolic homeostasis in health and disease. Tryptophan metabolism is involved in the development and progression of immune, nervous, and digestive system diseases. Although some excellent reviews on tryptophan metabolism exis...
Georgia has many millennia of climatic and balneological traditions. Borjomi is distinguished by its unique carbonated mineral waters, the composition of which contributes to the normalization of the digestive system and metabolic functions. Tskaltubo healing waters, which are characterized by high radon activity, are successfully used in the treat...
Access to recreational areas is particularly important in the context of improving the quality of life in cities. One of the valuable elements of such areas may be water reservoirs and their accompanying springs. An example of such a recreational area is the so-called Palowice Lake District (southern Poland), which includes three water reservoirs,...
Hepatic, biliary, and pancreatic cancer pose significant challenges in the field of digestive system diseases due to their highly malignant nature. Traditional Chinese medicine (TCM) has gained attention as a potential therapeutic approach with long-standing use in China and well-recognized clinical benefits. In this review, we systematically summa...
This study aimed to analyze the structure of polysaccharides from eight different Dendrobium species and their protective effects on gastric mucosa. Ultraviolet (UV) analysis showed that the contents of eight polysaccharides ranged from 51.89 ± 6.91% to 80.57 ± 11.63%; the degree of acetylation ranged from 0.17 ± 0.03 to 0.48 ± 0.03. High-performan...
Background
Numerous digestive system adverse events (dsAEs) have been observed during the use of anti-obesity medications (AOMs), leading to concerns about the safety of these medications. However, most current studies are limited to the association of one class of drugs with specific digestive disorders, and there is no cascading analysis of AOMs...
Nicotinamide mononucleotide (NMN), a crucial intermediate in NAD + synthesis, can rapidly transform into NAD + within the body after ingestion. NMN plays a pivotal role in several important biological processes, including energy metabolism, cellular aging, circadian rhythm regulation, DNA repair, chromatin remodeling, immunity, and inflammation. NM...
With the development of society, people's lifestyle and eating habits have also changed, and the incidence of digestive diseases has gradually increased. Chronic atrophic gastritis, as a digestive system disease, is very common in clinical practice. Due to its chronic diseases, long course, long treatment cycle, and slow treatment effect, it brings...
Pediatric febrile illnesses are relatively common in clinical practice, especially respiratory and digestive system diseases are most common, which can be said to be common and frequent. Whether in the acute or recovery period, improper dietary feeding and protective measures occur from time to time, which can easily lead to recurrence, delay, aggr...
Intestinal polyp is a common digestive system disease, and its incidence is increasing, among which adenomatous polyp is the main type of precancerous transformation of colorectal cancer. In traditional Chinese medicine, this can be classified as "intestinal mushroom" or "accumulation" and other diseases. "Yang transforming qi and yin forming" mean...
Background
The Correa’s cascade, encompassing chronic non-atrophic gastritis, atrophic gastritis, intestinal metaplasia, and dysplasia, represents the well-recognized pathway for the development of non-cardia gastric cancer. Population-based studies on all-cause and cause-specific mortalities among patients with gastric lesions in Correa’s cascade...
Article
Background
Evaluating the impact of digestive system diseases is vital for devising effective prevention strategies. However, comprehensive reports on the burden of digestive system diseases in China are lacking. Our study aimed to provide an overview of the burden and trends of digestive system diseases from 1990 to 2019 in China and its...
Objective: To investigate the correlation between the Atherogenic Index of Plasma (AIP), Body Mass Index (BMI), and sarcopenia in the elderly Chinese population, and to analyze the predictive ability of AIP and BMI for sarcopenia.
Methods: A retrospective analysis was conducted on 3,709 eligible participants aged 60 and above, based on data from t...
Background and aim
Yueju Pill (YJ) not only has good antidepressant effect but also can effectively treat digestive system diseases. However,it remains unclear whether the mechanism of antidepressant action of YJ is related to the peripheral digestive system. The purpose of this study was to elucidate the antidepressant mechanism of YJ on ghrelin l...
Background: For hospitalized adults, it is important to initiate the early reintroduction of oral food in accordance with nutrition support team guidelines. The aim of this study was to develop and validate a machine learning-based algorithm that predicts the early termination of medical nutritional therapy (the transition to oral feeding). Methods...
Worldwide, gastric cancer (GC) is a common malignancy with the highest mortality rate among digestive system diseases. The present study of GC and loss of heterozygosity (LOH) is relevant to understanding tumor biology and establishing essential aspects of cancer. Here, DNA samples from Mexican patients with diffuse GC (DGC), intestinal GC (IGC), o...
This paper discusses the important role of TCM physical factors in the pathogenesis and evolution of asymptomatic spleen and stomach diseases, and points out that people with asymptomatic spleen and stomach diseases have different physical types. By expounding the correlation between physique and pathological constitution type, cause, treatment, me...
The study is dedicated to analyzing the effectiveness of comprehensive treatment of periodontal tissues in patients with digestive system diseases who use non-removable prostheses. The work considers the connection between periodontal diseases and digestive system disorders, emphasizing the importance of an integrated approach to treatment. A signi...
With the general improvement in living standards in recent years, people’s living habits, including their dietary habits, have changed. More people around the world do not follow a healthy diet, leading to an increase in morbidity and even mortality due to digestive system diseases, which shows an increasing trend every year. The advantage of tradi...
Traditional Chinese medicine (TCM) relies on specific combinations of herbs in prescriptions to treat symptoms and signs, a practice that spans thousands of years. Predicting TCM prescriptions presents a fascinating technical challenge with practical implications. However, this task faces limitations due to the scarcity of high-quality clinical dat...
The global development of livestock production systems, accelerated by the growing demand for animal products, has greatly contributed to land-use change, greenhouse gas emissions, and pollution of the local environment. Further, excessive consumption of animal products has been linked with cardiovascular diseases, digestive system diseases, diabet...
Constipation is a common and prevalent digestive system disease in clinical practice, which seriously affects human physical and mental health. Currently, chemical drugs have good short-term therapeutic effects. However, because of their adverse reactions, easy recurrence after drug discontinuation, and dependence with long-term use, the long-term...
Plants that have been used under the name of traditional treatment for many years have been supported by recent studies. We use plant species as bioactive phytochemicals in many areas of our lives. In addition to being used in cosmetics, food, medical, and industrial applications, it is a potential product for preventing diseases with the compounds...
Autophagy, a conserved cellular degradation process, is crucial for various cellular processes such as immune responses, inflammation, metabolic and oxidative stress adaptation, cell proliferation, development, and tissue repair and remodeling. Dysregulation of autophagy is suspected in numerous diseases, including cancer, neurodegenerative disease...
The aim of the present study was to evaluate the diagnostic value of plasma human cystatin-S (CST4) in patients with digestive system malignant tumors. CST4 and tumor markers, such as α-fetoprotein (AFP), carcinoembryonic antigen (CEA), carbohydrate antigen (CA)199, CA125, CA153 and CA724, were detected in blood samples from 100 patients with a dig...
Intestinal disease is a group of complex digestive system diseases imposing a significant burden globally. Identifying the risk factors and potential complications of intestinal disease is important for its prevention and treatment. However, traditional observational clinical studies are limited by confounding factors and reverse causation, making...
Digestive system diseases, such as gastritis, gastric ulcers, chronic liver disease, inflammatory bowel disease (IBD), and colorectal cancer, represent a major group of diseases that have high morbidity and death rates worldwide. Their incidence continues to rise owing to factors such as dietary structure changes, accelerated lifestyles, increased...
Mitochondria, the most crucial energy-generating organelles in eukaryotic cells, play a pivotal role in regulating energy metabolism. However, their significance extends beyond this, as they are also indispensable in vital life processes such as cell proliferation, differentiation, immune responses, and redox balance. In response to various physiol...
Background
Interest in large language models (LLMs), such as OpenAI's ChatGPT, across multiple specialties has grown as a source of patient‐facing medical advice and provider‐facing clinical decision support. The accuracy of LLM responses for gastroenterology and hepatology‐related questions is unknown.
Aims
To evaluate the accuracy and potential...
Digestive system diseases are common in the population and may have a potential relationship with erectile dysfunction (ED), however, there are few studies on the effect of digestive system diseases on ED, and its relationship is not clear. This study aims to investigate the causal relationship between digestive system diseases and ED, and assesses...
Background
Cerebrovascular disease, among the most prevalent neurological disorders, poses a substantial threat to human health with its elevated mortality and disability rates, placing considerable strain on healthcare systems. Although several studies in recent years have suggested a potential association between digestive system diseases and cer...
Background
Sleep problems are prevalent. However, the impact of sleep patterns on digestive diseases remains uncertain. Moreover, the interaction between sleep patterns and genetic predisposition with digestive diseases has not been comprehensively explored.
Methods
410,586 participants from UK Biobank with complete sleep information were included...
Introduction
China has experienced unprecedented transformations unseen in a century and is gradually progressing toward an emerging superpower. The epidemiological trends of digestive diseases in the United States (the US) have significant prescient effects on China.
Methods
We extracted data on 18 digestive diseases from the Global Burden of Dis...
Patient: Male, 62-year-old
Final Diagnosis: Cryptogenic multifocal ulcerative stenosing enteritis (CMUSE) • itestinal stenosis
Symptoms: Abdominal pain • the edema of bilateral lower extremity
Clinical Procedure: Segmental small intestine resection
Specialty: Surgery
Objective
Rare disease
Background
Cryptogenic multifocal ulcerating stenosing en...
Protein ubiquitination is an enzymatic cascade reaction and serves as an important protein post-translational modification (PTM) that is involved in the vast majority of cellular life activities. The key enzyme in the ubiquitination process is E3 ubiquitin ligase (E3), which catalyzes the binding of ubiquitin (Ub) to the protein substrate and influ...