Questions related to Diabetes Mellitus
Due to its continuously increasing occurrence, more and more families are influenced by diabetes mellitus. Most diabetics know little about their health quality or the risk factors they face prior to diagnosis.
The use of statins have been associated with the onset of diabetes mellitus in persons with risk factors for DM. In persons trying to reverse diabetes, in your experience, has the use of statins prevented or reduced the rate at ehich this DM reversal would occur?
Am looking at hla 2 association with diabetes mellitus and one of my objectives is to study the distribution of the alleles in my study group plus controls. What else can I do? Please help
Some researchers suggest starting an anti-diabetic treatment after 1-2 weeks of the Streptozotocin injection (single injection) in rodents models, indicating that this will mimic a later-stage of diabetes. While others suggest that there is no need to wait such time and start the treatment immediately after the confirmation of diabetes. I’m quite confused which is the best time to start the anti-diabetic treatment? is the time post the confirmation of diabetes really mimic the diabetes stages in human?
I would appreciate if you can answer whether you prepare glucose solution for injection in mice in NaCl solution or just in water and why!
We are performing an antidiabetic assay by inducing alloxan in rats and we have to share with metformin, glibenclamide, or actrapid for the positive control.
Which of these three drugs is the best to use?
Unbooked primigravida diagnosed with diabetes mellitus of 3 years duration and defaulted on taking her medication, presented with IUGR, was delivered of female infant of 1.7 kg at term. The mother has no renal pathology and the baby has no congenital anomaly.
Allosteric binding sites are different from the active sites. If insulin receptor has this characteristic then it will be easy to target the receptor in insulin associated disorders.
I want to assess the social burden of Major Non-communicable diseases (Diabetes Mellitus) and which instrument will address the societal burden of the diseases.
thanks in advance for the genuine support and advice.
Treating children known to have metabolic disorders often includes ensuring adequate amount of calories for age and weight to avoid catabolism, that is usually by giving glucose solution 10%.
What is the long term impact of the sugary fluids on these patients?
Does it contribute to generating some degree of insulin resistance?
Can we predict the insulin resistance if so?
will HOMA-IR serve as a good predictor test?
Alloxan or streptozotocin is a common agent used for induction of diabetes mellitus in rodents. From my experience, not all rats administered alloxan or streptozotocin developed diabetes mellitus. In most cases, this cannot be attributed to drug-/administration-related factors such as potency, underdosages, route of administration, wrong administration, etc. Are there studies that have investigated the resistance of these agents in some rodents? Are there scientific explanations or reasons for this resistance?
Vitamin-D plays role in maintaining insulin secretion from pancreatic beta cells. Vitamin-D deficiency contributes to the development of insulin resistance and onset of diabetes. Does vitamin-D supplementation in deficient patients prevent the development of diabetes? If so, what will be the minimum daily/weekly amount to be supplemented?
Discussion on the best options for management of hypertension, T2 diabetes mellitus in the context of macroalbuminuria is sought to get an insight into the matter.
As a public health measures to control the spread of the pandemic coronavirus, social distancing and home quarantine are implemented in some countries.
As a matter of fact, patients are absence from clinic under COVID-19, and clinic-based diabetic control monitoring becomes challenging.
Do you expect a change in diabetic control for these patients when staying home?
They have less exercise, and may eat more snacks at home.
Or in contrast, they are too bored, and have time to develop new exercise without pressure from work? Besides, they are banned from social around, and may eat drink less alcohol and eat less feast.
What do you think?
Can anybody suggest me one/more plant names for doing project either in alone or combination therapy of diabetic mellitus, wound healing and anti oxidant property?
I´m doing research on adherence to lifestyle and medication in Diabetes Mellitus Type 2 patient. I have trouble with finding the following questionnaires. I would be grateful if someone could help me with this.
o Cologne Patient Questionnaire (CPQ)
o Autonomi Preference Index (API)
o Decision Conflict Scale (DCS)
o Sherer General Self-Efficacy Scale (SGSES)
o Psychometric Evaluation of the Adherence in Diabetes Questionnaire (ADQ)
1) could I use chi-square for one nominal and one ordinal variable or it uses only for nominal variables? 2) if I have only positive result can I find p-value in variables e. g. Finding relation between positive diabetes mellitus with respect of gender, race and.... Or I should report them as frequency without mentioning p-value?
We have now tried a number of commercially available antibodies to detect the receptor of AGEs (RAGE, sometimes called AGER) in parrafin embedded mouse tissue with DAB staining. As a control we have used corresponding tissues of a RAGE-KO mouse. Whereas most of these antibodies worked well in lung tissue that accumulates RAGE to a high amount, we have faced significant problems when using tissues that express only minor amounts of RAGE. In particular we observed cross reactivity with muscle cells. If anybody has had good results using an anti RAGE antibody for IHC in mouse tissue please let us know!
Genomics of diabetes mellitus......can this in anyway improve nursing care for diabetic patient?
I need a technique or procedure that accurately diagnoses the type( I or II ) of diabetes mellitus in experimental albino rats
Diabetes mellitus type2 induction in experimental animals involves a biochemical link between diet and a chemical like streptozotocin. Is it possible to achieve the same result with a high-sucrose diet with streptozotocin and high-sucrose-high-fat-diet with streptozotocin?
The dental implant became one of the routine dental clinic work, and further patients with diabetes mellitus asking for dental implant.
After exposing rats to low fructose water(10%) for 2 wks and a single intraperitoneal injection of STZ (55mg/kg bw), to induce T2D, I want to compare the hypoglycaemic effect of my crude plant extract with a known standard drug.
I am looking for other diagnostic marker for Type II Diabetes Mellitus. We are currently studying leptin as one of the potential diagnostic marker of this disease.
1 - Can continous stress induce high glicemic rates in humans and trigger diabetes type1 ou 2? How those possible stress induced problens are related to age? Can those high glicemic rates or diabetes be controled or cured by eliminating stress?
2 - Which type of individuals (comportamental behavior – fleumatic, coleric, introspective, .....) are more sensitive to high glicemic rates due to stress?
3 - Is there any conclusive study showing inducing diabetes or glicemic discontrol in humans by stress?
4 - Can high glicemic rates induced by stress or other metabolic problem be confused with diabetes melittos in children and juvenile populations?
5 - Which types of blood indicators and/or organs images (liver, pancreas, and so on) are important to assure that the diabetes mellitus be present in children and juvenile populations
There is little available information regarding the evolution and outcomes of patients with diabetes mellitus who acquire leishmaniasis, tegumentary or visceral. We are documenting a series of cases but we have been able to found significant references on that looking at medline, SCI, Scopus, SciELO and LILACS databases.
We are the one need the link. Thanks for kindness share paper and links.
How can I know if in a paper they are talking about gestational diabetes (the condition what starts during pregnancy) or gestational diabetes mellitus (women who had diabetes mellitus before being pregnant?
I have seen that in some papers they talk about gestational diabetes mellitus as the condition that appears during pregnancy and sometimes about women who had DM before being pregnant. Or the two conditions are equal?
Thank you for your help
rapid progress is acheived in the field of diabetes researches and techn ologies. is it time to make use of revolutionary sciencessuch as proteomics,transcriptomics, metabolomics and exposomics. Associating all these multidisplinary sciences in a unified system may transform healthcare for diabetes mellitus patients including novel molecular biomarkers, new diagnosstic and therapeutic modalities.
I am completing my M.D. in Biochemistry from JIPMER Puducherry. After this i want to work in the field of diabetes mellitus especially to understand the mechanism behind its complications.
How do we tackle diabetes 2?
Obesity and diabetes are the two most debilitating and insidious diseases; and its scientifically proven, beyond any reasonable doubt, that its largely due to unhealthy lifestyle choices. In that case isn't it imperative to bring general awareness to the public about inculcating a healthy lifestyle?
Ultimately where should the lime light be focused - the never ending research or stressing on the dire need to switch over to healthy diet and active lifestyle?
A1c is now routinely recommended for diagnosis of diabetes mellitus. However, I feel A1c variation owes a lot to patient & technology specific factors. So can u generally share our experience for diagnosing DM with A1c?
Fasting hyperglycemia and diabetes mellitus;
In clinical laboratory practice I had seen so many cases of type-II diabetes mellitus who gets a diagnosis of diabetes mellitus based upon raised fasting glucose but once u subject them with glucose load they easily manage there load. No doubt that fasting hyperglycemia is not not normal but i guess relying simply on fasting hyperglycemia, we may be overdoing the diagnosis part and in my personal opinion i feel w-hour postprandial glucose tolerance in an other wise healthy subject with any GIT pathology must be given to all subjects. Another thing which i have realized that once these subjects with fasting hyperglycemia reduce theri liver fat, they can overcome fasting hyperglycemia.
So fasting hyperglycemia and postprandial glucose tolerance are two varied concepts and the latter is a serious category. Then even thin, lean sometimes show poor glucose tolerance. And to me the latter category is worrisome rather than isolated fasting hyperglycemia.
So anybody wishes to comment on this? OR explain OR give some reasoning behind this?
Dear All, I am trying to apply data mining and machine learning techniques in diabetes prediction. Therefore, I need more data.
I understand that, there is a Pima indian and UCI database. But this not enough, what i need.
The required data can be
e.g., Age, sex, glucose, LDL, HDL, BMI, HbA1C and other variables and short and long term outcome of the subject. Outcome can be defined by good and poor outcome.The poor outcome can be chronic disease or CVD.
I would like to collaborate.
Your cooperation will be highly acknowledged.
Waiting to hearing from you.
HbA1C shows the previous glycemic status of a patient this is understood but can it be a predictor of some other conditions where glycemic status is normal but HbA1C levels show elevations ?
I'm doing a research to reveal the effect of gestational diabetes on stem cells number and comparing with the non-diabetic group.
and what is the sample size formula for it?
Patient who is age of 65 is suffering from Hyperglycemic Hyperosmolar Nonketotic Syndrome has elevated levels of Potassium levels on serum electrolytes, But has total body potassium depletion ?
what is the mechanism ?
Dysmenorrhea is the commonest complain in the female adolescents and affects their regular activities .It is the leading cause of absenteeism from work place, school and college, limitation on social and sports activities among that population. In some places government provided 2 days special leave for women employees. But they rarely use it for this purpose. In our state Bihar also, Bihar state government provide 2 days special leave for women
In our study 200 women between age group of 17-25yrs., participated from my clinic after getting their consent. They were not suffering from hypertension, Diabetes mellitus renal or hepatic disorders .Detail history was taken. Height and weight were recored.
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The topic of my research proposal is Knowledge Attitude and Practice (KAP) about lifestyle modifications among type 2 diabetic patients attending Federal Medical Centre Katsina.
To assess the Knowledge, Attitude and Practice on life style modification amongst outpatients attending Federal Medical Centre Katsina Diabetes Mellitus clinic.
Looking for a portable ketometer for use in dogs and cats, evaluated with a clinical trial.
Hypertensive patients with diabetes mellitus 2 type have more often and early renal dysfucntion due to negative influence of 2 diseases. There is a cut-off of kidney function according to GFR - lower then 60 ml/m2/1.73. But what about hypertensive patients with diabetes with 60-89ml/m2/1.73 - with mildely decrease GFR?
In patients with this GFR level can we declare about kidney organ damage?
Is it 10hour or 12hrs time period for finding exact blood sugar level and evaluating lipid profile.
Epidemiological and basic science evidence suggests a possible shared pathophysiology between type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). It has even been hypothesized that AD might be ‘type 3 diabetes’. The present review summarizes some of the evidence for the possible link, putative biochemical pathways and ongoing clinical trials of anti-diabetic drugs in AD patients.
Is plate method suitable for male and female patients?
How can educate male and females about portion size of plate?
Can plate method used for type 2 DM patient with ideal body weight?
As Diabetes mellitus type 2 has increased tremendously in the world, so polyherbal formualtion (share some trade or generic names) used in some couuntries. So we should be aware of this if benefits found in some formulations. Many review articles are also available for the support of this kind of activities in plants.
could any one please explain to me how to estimate sample size for genetic polymorphisms studies in type 2 diabetes mellitus?
i need to find two SNPs in diabetes mellitus type 2 patients,but i dont know how many samples i need and how to calculate sample size
I have a program that took years to develop on improving healthcare behaviors of patients with diabetes. The program is in both English and Spanish. It’s purpose is to help patients who do not have access to specialists in diabetes or to help diabetes specialist who can not spend all the time necessary for carefully managing the healthcare behaviors of their patients. I am retired and no longer can use the program. It is yours for the asking.
I am interested in determining a patient's post-prandial capacity to release GLP1. Can I use glucose or does it need a meal tolerance test?
We have a case where a 13 years old female mixed dog with insulinoma underwent surgery to remove a well-encapsulated insulinoma. After the surgery it was treated with toceranib fosfat (Palladia). Before the surgery this dog had hipoclucemic crysis and after the surgery those still appears more frequently than before. So we want to know if those attacks are real hypoglycemic crisis or are related with hipokalemia so how the serum potassium behaves? Greetings.
I would like to assess insulin signaling in adipose tissue of mice. Do I have to starve animals prior sacrifice or not? Or may I put tissue in proper buffer/medium, right after explant, even if I did not starve animals? Perhaps I can leave adipose tissue without nutrients for a period of time to mimic starvation and then add insulin and after 15-30 minutes assess its action, does it make sense?
What are the differences between stz and aloxan diabetogenic agents? Which one is best for inducing type 1 diabetes in mice?
We are trying to establish a STZ induced T1DM rat model. Usually STZ dosage from most literature is about 50~65 mg per kg and the blood sugar after treatment is around 350~500 mg/dL in SD rat. But the blood sugar of our SD rats all exceeded 600mg/dL within one week. Then we reduced the dosage to 45 mpk and 30mpk, the blood sugar after treatment still exceeded 600 mg/dL within one week. We also used multiple shots like 15mpk for 3 days, the blood sugar raised to 200mg/dL but went back to normal soon. Are our SD rats too sensitive to STZ? Some people used insulin to control blood sugar and body weight on STZ rat, will insulin interfere the efficacy of anti-diabetic drug?
Heat Therapy With Relevance to the Reversal of NAFLD and Diabetes. J Diabetes Metab Disord 4: 018.
Am starting to collect a small set of diabetes relevant (T1) time series data (movement, blood glucose, sleep, etc.) Have talked to many people who are doing such research, but few people seem to know how to process the data. Some have suggested ARIMA modelling, perhaps with ML for a variable window, but looking for any ideas or ideally someone who wants to co-author a research paper. Please get in touch if you have ideas, know relevant papers, or are interested. Thanks, Dmitri
I have difficulty in choosing the sink condition for in vitro release of Insulin, which is insoluble at pH 7.4. I red some articles used the combination of tween and cremaphore EL in the release medium for pH 7.4. I am wondering if there is any other way to maintain sink condition.