Development Methodologies - Science method

This work is concerned with the simulation of pavement behavior using the Finite Element Method (FEM) with the goal of predicting the appearance of cracks during its useful life. The developed method can help maintenance planning towards providing users with safety and comfort. The effects of both traffic loads and temperature variations are consid...

Inherently chiral eight‐membered rings embedded in tetraphenylene derivatives and hetero‐analogues exhibit unique properties and allow diverse applications. A conceptually viable and straightforward approach to these frameworks is [4+4] cycloaddition, which still remains elusive. Herein, we describe the stereoselective cross‐[4+4] cycloaddition of...

The d-transition kagome metals provide a novel platform for exploring correlated superconducting state intertwined with charge ordering. However, the force of charge-density-wave (CDW) and superconductivity (SC) formation, and the mechanism underlying electron pairing remain elusive. Here, utilizing our newly developed methodology based on electrid...

Anthocyanins have gained significant attention for their potent colorant capacity and multifaceted biological activities. As a result, the quantification of anthocyanin content in wild berries and the identification of anthocyanin profiles have become increasingly important, as well as the optimization of methods for these determinations. The prese...

Trip-level household travel surveys (HTS) are an efficient and widely used instrument in transport planning and research and are expected to remain in this role for at least the near future. Mode information is typically assigned to trips in these surveys based on a hierarchy of transport modes that hides important information on the individual sta...

Objective: The objective of this study is to investigate the development of a sustainable and collective business model, by and for the community, aiming, in principle, at its economic emancipation. Theoretical Framework: Today, cooperation is recognized as a source of efficiency and well-being, opposing competition, rational selfishness and neolib...

This study focused on the development of an Autonomous Underwater Vehicle (AUV) across four key domains: Mechanical Design, Software, Electronics, and Security. The Mechanical Design phase involved utilizing computer-aided drawing programs to create the AUV model. Important design considerations encompass manufacturability, cost, power, weight, and...

THE PURPOSE OF THE ARTICLE is to study methodological approaches to assessing and realizing the investment potential of the country’s economy in the context of sustainable development. RESEARCH METHODS. In writing the article, the following research methods were used: analytical method – to study the indicators of the country’s investment potential...

In this chapter, we examine the burgeoning scholarship on legitimacy and briefly summarize the intellectual trajectory of this important concept. We discuss current conversations in legitimacy research and suggest future research directions that we believe are necessary not only to advance scholarship on organisational legitimacy but also to inform...

Remote analysis of the chemical composition of various substances in real time is a pressing problem. Current development of the fiber based evanescent wave spectroscopy (FEWS) in the mid-infrared range meets modern industrial, environmental, safety and medical needs. This paper presents a sensitivity analysis of the fiber probes for FEWS based on...

Introduction. Forensic medical investigations, including illustration, evidence collection, and expert conclusion preparation, have faced significant challenges in recent years. One of the primary challenges for Ukraine’s forensic medical service today is the examination of firearm-related injuries, necessitating substantial improvements to traditi...

2024, № 1-2 (135-136) 125 according to the research program), reflective (presupposes the development of reflective processes and means the possession of knowledge and skills to analyze the results of activities, i.e. to correlate the achieved results with the goal, the ability to interpret the obtained data; to conduct self-evaluation of the resea...

Heating accounts for significant primary resource consumption and generation up to 30 % of total GHG emissions in the EU27. The ambitious emissions reduction goals outlined in the European Green Deal and Fit for 55 package necessitate not only the massive renovation of building stocks, but also reconstruction of heat generation and supply systems....

Overtourism results in pressure exerted on the natural environment, negative impacts on local communities and lower tourist satisfaction in many protected areas (PAs). This phenomenon has become an increasingly important issue in the management of national parks (NPs) in Poland, especially the mountain ones. Countering and alleviating the effects o...

Agriculture 4.0, or smart agriculture, pertains to the integration of advanced technologies such as IoT, cloud computing, robotics, and AI in the agricultural production process. Through the implementation of these technologies, farmers can efficiently manage resources and make informed decisions based on data to enhance crop yields, minimize waste...

The environmental doctrine of the Russian Federation determines the need to develop methodological grounds for monitoring climate risks of territories. In general, climate monitoring is a comprehensive evaluation of the climate change impact on all aspects of human life without exception, since climate change inevitably affects the socio-economic p...

This paper presents a new developed methodology for teaching and learning subjects that although are very important in the modern digital society are neglected in high school education programs: cybersecurity and cyber safety. A Study among the EU high schools in 2021–2022 revealed that computer science teachers are not regularly upgrading their kn...

When carrying out work on the proper maintenance of a number of linear infrastructure facilities, the problem of assessing the quality of work performed to remove unwanted trees and shrubs from the territories of these facilities remains relevant. Given that the quality of these works is often assessed only by considering the regulatory and technic...

Different human activities have a significant impact on the quantity and quality of water resources, which highlights the importance of implementing a comprehensive management of water resources. In order to address this complex issue, strategic and tactical planning needs to consider social, nature, and economic variables. The goal of this paper w...

Modern energy systems are undergoing significant changes due to the active implementation of renewable energy sources, control devices based on power electronics, the development of transient processes control systems and monitoring, as well as digitalization of production, transmission and distribution electricity processes. These changes contribu...

Context. Spectroscopic surveys like APOGEE, GALAH, and LAMOST have significantly advanced our understanding of the Milky Way by providing extensive stellar parameters and chemical abundances. Complementing these, photometric surveys with narrow/medium-band filters, such as the Southern Photometric Local Universe Survey (S-PLUS), offer the potential...

Long-lasting extreme weather conditions are expected to occur more frequently in the future owing to climate change, as demonstrated by the recent heat waves. In particular, the decrease in precipitation during the summer months had a significant impact on urban tree water availability. Therefore, it is imperative to develop methodologies for deter...

The Joule heat generated by current flow between electrodes in a resistance furnace not only melts and heats the charge but also induces mixing of the molten material. Increased mixing promotes improved chemical and temperature uniformity within the bath. This paper presents a novel approach to effectively optimizing electrode geometry in resistanc...

Cardiac fibroblasts, have lower gene transfer efficiency compared to dermal fibroblasts, posing challenges for plasmid-based gene transfer methods. A higher transfer efficiency could enable improved insight into heart pathology and development of novel therapeutic targets. In this study we compared eleven commercially available transfection reagent...

The transition from process-centric to user-centric tool development (PcD.UcT) is an innovative model designed to address challenges in predictive and adaptive software development. This review explores the PcD.UcT model as proposed by Pradeep and Wijesekara (2017), focusing on its utilization of various lifecycle model classes in the development o...

Characterisation of highly fractured and weathered rock masses within the young Tuang Formation in Sarawak, Malaysia is challenging, mainly due to the difficulties in extracting intact samples for conventional rock testing. Pressuremeter test was used as a viable alternative since it is performed in-situ, hence eliminating the need for sample extra...

Conferences are meetings whose purpose is to exchange thoughts and opinions on common issues. Advances in technology make people believe that work is more effective and efficient. One of them is changing the traditional system into a computerized system. Conference organizers more effectively disseminate information, record, broadcast, and conduct...

When mooring a ship near the quay, it is important to monitor its speed at the time of contact with the quay to ensure the safe execution of the mooring operation. During mooring, the speed of the ship must not exceed specified values; therefore, it is very important to have the possibility to measure it with high accuracy and its appropriate adjus...

Prenyl modification often improves the biological activities of compounds. Prenyltransferases have attracted attention as environmentally friendly biocatalysts for catalyzing prenyl modification of compounds. Compared to dimethylallyl modifications, research on geranyl modifications is relatively limited. To enrich biocatalytic toolboxes for genera...

This study addresses the problem of the automated synthesis of active fluid film bearings optimized for their adjustable design for new generations of turbomachines. The developed methodology proposes a criterion describing the ability of a bearing’s mechanical design to effectively implement control actions along with its energy efficiency and sta...

According to statistics from the World Health Organization, traffic accidents are one of the leading causes of death among children and young people, and statistical indicators are even worse for the elderly population. Preventive measures require an approach that includes analyses of traffic infrastructure and regulations, users’ traffic behavior,...

In his posthumously published collection of essays, Pope Benedict calls on the new generation of biblical scholars to develop methodological criteria for a “pneumatological exegesis” of the Old Testament. As a first step in this direction, the present article seeks to summarize Joseph Ratzinger’s/ Benedict XVI’s own theological reflection on the ma...

Drug development for children presents unique challenges and is highly regulated. Novel approaches, such as the use of extrapolation to address, for example, the need to avoid unethical studies, whilst supporting robust evidence generation have been developed in support of benefit/risk considerations by regulatory authorities. This is only one step...

Background and Objectives: Revumenib (SNDX-5613) is a powerful and specific inhibitor of the menin–KMT2A binding interaction. It is a small molecule that is currently being researched to treat KMT2A-rearranged (KMT2Ar) acute leukemias. Revumenib (RVB) has received Orphan Drug Designation from the US FDA for treating patients with AML. It has also b...

In this study, targeting acetylcholinesterase (AChE) related to Alzheimer’s disease, a screening method, affinity ultrafiltration combined with ultra-high-performance liquid chromatography–quadrupole-time-of-flight mass spectrometry (AUF–UHPLC–Q-TOF MS) was developed for the discovery and identification of AChE inhibitors from Phyllanthus emblica L...

This study describes the optimization of Distribution Network Structure (DNS) by altering sectionalizing and tie-switches with Reactive Power Injections (RPI) through optimal nodes under three load variations considering five different cases in Electric Distribution Networks (EDNs) to reduce Energy Loss (ELoss), thereby achieving Economic Benefit (...

Product Service Systems (PSSs) introduce new business models for enterprises to promote tangible products along with intangible functions or services, thereby incentivising product sustainability with profitability, economic stability and customer satisfaction. However, the unique characteristics of a PSS challenge obsolete product development proc...

The objective of this paper is to design and develop a comprehensive online accommodation platform aimed at simplifying the process of listing, searching, and booking accommodations for both travellers and property owners. The platform seeks to address common challenges faced by existing platforms, such as high fees, limited search options, and com...

The article presents the results of developing a tool to measure belief in the power of money. The questionnaire consists of 10 statements reflecting three semantic aspects of money: money as a support, money as a measure of everything, money as the main life resource - the key to well-being. The sample consisted of 442 people - citizens of Ukraine...

This paper investigates the appropriateness of machine learning (ML) and other techniques for modeling manufacturing processes energy consumption by developing a comparison methodology. Three research questions are posed: Firstly, how do prediction errors compare using different techniques with varying complexity and ML use? Secondly, how does perf...

This article is devoted to planning water-energy regimes for hydropower plants, taking into account economic and ecologic criteria. A new methodology based on a probabilistic model of water inflow has been proposed. The probabilistic method requires the calculation of low-water and average-water year typical hydrographs based on the probability cur...

This project is a clinic management system that will be used to solve the current problems that facing by the local clinic in Malaysia. Clinic Management System is a web-based platform system. The main objectives of this project is to improve the business process of the clinic in Malaysia by using the information technology and also enhance the cu...

Large Language Models are prone to off-topic misuse, where users may prompt these models to perform tasks beyond their intended scope. Current guardrails, which often rely on curated examples or custom classifiers, suffer from high false-positive rates, limited adaptability, and the impracticality of requiring real-world data that is not available...

Purpose Artificial intelligence (AI) holds great potential for revolutionizing health care by providing clinicians with data-driven insights that support more accurate and efficient clinical decisions. However, applying AI in clinical settings is often challenging due to the complexity and vastness of medical information. This perspective article e...

As software organizations scale, the migration of internal platforms becomes increasingly critical yet exponentially more complex than traditional external platform migrations. This paper presents a comprehensive framework for managing large-scale internal platform migrations, addressing the unique challenges of transitioning business-critical syst...

Developing a competitive product with significant economic advantages presents a formidable challenge in today’s business landscape. Organizations can overcome the challenge by employing the House of Quality (HOQ), a well-established product modification and development methodology. This paper endeavors to investigate the pragmatic utilization of t...

The paper presents the developed methodology and designed a device for determining the Mach number during supersonic gas outflow. An analysis of various methods for determining the Mach number was carried out, including measuring the pressure at the flow boundary, the use of shock waves, and the use of optical methods. A comparison was made of the...

Cloud computing (CC) is the rapid utilization of network resources, specifically processing power and data storage, without the need for extra or direct customer management. One of the crucial and difficult problems facing the scientific and business user communities is ensuring security and trust between users (\documentclass[12pt]{minimal} \usepa...

This study analyzes valuable information (image feature information) from pixel-based images to systematize the form generation process utilizing this information. Information in architecture is mainly used as an analytical tool for functional design optimization. However, the Fourth Industrial Revolution and advances in information and communicati...

The EMA Qualification of Novel Methodologies procedure qualifies methods, technologies and methodologies within a well-defined context of use in a pharma R&D context based on the evaluation of the presented scientific rationale and submitted data. This policy brief analyses QoNM submissions providing policy messages and recommendations to stakehold...

Artificial Intelligence (AI) technologies can potentially revolutionize the aerospace industry with applications such as remote sensing data refinement, autonomous landing, and drone-based agriculture. However, safety concerns have prevented the widespread adoption of AI in commercial aviation. Currently, commercial aircraft do not incorporate AI c...

The interaction between off-road vehicles and terrain in forestry operations has been extensively studied to assess machine performance and soil damage, emphasizing the importance of the relationship between machine mobility and terrain conditions. This study assesses the rolling resistance coefficient (μr) using engine data acquired through CAN-bu...

Personalised medicine (PM) research programmes represent the modern paradigm of complex cross-disciplinary research, integrating innovative methodologies and technologies. Methodological research is required to ensure that these programmes generate robust and reproducible evidence. The PERMIT project developed methodological recommendations for eac...

Este artículo presenta un roadmap para el control de los datos de la información en los ámbitos de desarrollo de aplicaciones de software para las grandes, medianas y pequeñas empresas de desarrollo de aplicaciones en línea, las cuales son vulnerables por la falta de controles o políticas que permitan la protección de la información de ataques no d...

Achieving the Sustainable Development Goals (SDGs) requires collaboration among various stakeholders, particularly governments and non-state actors (NSAs). This collaboration results in but is also based on a continually growing volume of documents that needs to be analyzed and processed in a systematic way by government officials. Artificial Intel...

Currently used machine diagnostic systems are based on very modern solutions based on the acquisition and recording of their operating parameters in real time. Increasingly available and high-tech sensor systems mean that the number of recorded parameters is increasing and their quality is improving. These data are mainly used to assess the technic...

The integration of early childhood applications is increasingly common. However, in this process, educators often use academic apps from Apple and Android stores, believing they will enhance children’s training. However, most of these apps, not designed by preschool educators, fail to enhance the training processes in early childhood education. Thi...

China National Health Commission issued an implementation plan for budget performance management in health projects in April 2021, which emphasizes all health projects must be evaluated in advance prior to implementation. The study aims to develop an ex-ante performance evaluation framework for health projects and formulate a self-assessment report...

This research studies the potential of frozen low lunar orbits to be used in the design of constellations for global and regional communication or navigation. We introduce a robust two-stage approach to the frozen low lunar orbit design based on the successive application of non-gradient techniques, the Bayesian optimization and the Nelder–Mead met...

The complexity of software is increasing day by day the requirement and need for a verity of softwareproducts increases, this necessitates the provision of a strong tool that will make a balance betweenproduction and quality. The practice of applying software metrics to the development process and to asoftware product is a critical task and crucial...

Objective: The objective of this study was to develop a robust Liquid Chromatography – Tandem Mass Spectrometry (LC-MS/MS) methodology for the precise quantification of metformin and rosiglitazone in human plasma. Methods: A Design of Experiments (DOE) framework was utilized, specifically employing a Box-Behnken experimental design, to optimize cri...

The energy sector relies on numerical model output forecasts for operational purposes on a short-term scale, up to 10 days ahead. Reducing model errors is crucial, particularly given that coarse resolution models often fail to account for complex topography, such as that found in Costa Rica. Local circulations affect wind conditions at the level of...

The covalent attachment of peptide antigens to the NKT cell agonist, α‐galactosylceramide (αGalCer), generates self‐adjuvanting vaccines that prevent and/or eliminate disease in animal models of cancer and infectious disease. To date, the manufacture of these glycolipid‐peptide (GLP) conjugate vaccines utilises an automated solid‐phase process to p...

The work covers the developed model of minimization of active power shortage taking into account the balance of active and reactive power. The motivation for the formation and testing of this model is the need to improve the adequacy of models of this class, as well as the need to implement it in the developed methodology for assessing planned reli...

The increasing adoption of remotely piloted aircraft systems in urban areas will require a quantitative assessment of collision risks with other air traffic. Current approaches for assessing the effectiveness of detect and avoid systems may have limitations in both accounting for the influence of traffic coordination in controlled urban airspaces a...

The increasing installation of shrimp farms in vulnerable coastal areas around the world generates an environmental impact and makes it urgent to develop methodologies and studies for assessing and scaling the potential risks and sustainability of these activities. One of the main hazards of these activities is that the prolonged inundation of exca...

In support of the Dam and Levee Safety Programs of the United States Army Corps of Engineers (USACE), the Risk Management Center (RMC) develops tools and software; advances policy, methodology, and guidance; provides technical advising and training; and performs complex analyses, design services, and construction oversight for the highest priority...

Uveal melanoma (UM) is a rare aggressive intraocular tumour that spreads most commonly to the liver in tumours with loss of one copy of chromosome 3 (HR-M3); current treatments for metastatic disease remain largely ineffective. Pre-clinical research is increasingly using three-dimensional models that better recapitulate the tumour microenvironment...

Purpose-This paper delves into the traditional ecological knowledge (TEK) and practices of Burj Rashid, an ancient historical city on Egypt's northern coast, which stands at the meeting point of the Nile's western branch and the Mediterranean Sea. Burj Rashid boasts a strategic location and rich natural resources and has a long history of relations...

This research aims to develop an Android-based employee attendance application using the Geofence method at PT Wahanakarsa Swandiri. The company's main issue is the manual attendance system, which is prone to manipulation and inefficient for monitoring employee attendance, especially for those working at project locations that frequently change. Th...

Test-Driven Development (TDD) is a powerful software development methodology where tests are written before the actual code, enabling developers to build reliable software, accelerate feedback loops, and simplify maintenance. Despite these benefits, TDD can be time-consuming, requiring significant effort to write test cases, and demanding high leve...