Dermatology - Science topic

Background Rashes are common among patients with infections. A prior survey of United States adult infectious disease (ID) fellowship program directors showed that most respondents (55/90; 61%) do not have a formal dermatology curriculum for their fellows and 76% (41/54) were interested in incorporating an externally produced dermatology curriculum...

Background Vigorous administration of Covid-19 vaccines to tackle the ongoing pandemic has led to increasing research on adverse effects including both systemic and cutaneous. A prospective observational study to delineate cutaneous adverse effects of two vaccines namely Covishield and Covaxin administered in two doses in northern India. Methods T...

Introduction: Skin cancer is currently the most common cancer type worldwide, and numbers are rapidly increasing. To improve primary prevention, individualised prevention strategies may be of interest as this enhances the chance of long-term behavioural change. The Sun Exposure and Protection Index (SEPI), previously validated in multiple languages...

Background Multisystem inflammatory syndrome in children (MIS-C) is an uncommon but severe hyperinflammatory syndrome occurring weeks after SARS-CoV-2 infection. Presentation can vary and overlap with other conditions, including acute COVID-19 and Kawasaki disease. Identifying clusters of MIS-C phenotypes informs efforts to reduce misclassification...

Viral skin infections pose a significant health concern worldwide, causing discomfort, pain, and potential complications. The development of effective treatments for these infections is crucial in minimizing their impact on individuals’ quality of life. In recent years, there has been growing interest in the potential use of copper nanoparticles as...

Physiologically based pharmacokinetic (PBPK) models of skin absorption are a powerful resource for estimating drug delivery and chemical risk of dermatological products. This paper presents a PBPK workflow for the quantification of the mechanistic determinants of skin permeability and the use of these quantities in the prediction of skin absorption...

Skin pigmentation abnormalities, ranging from aesthetic concerns to severe hyperpigmentation disease, have profound implications for individuals’ psychological and economic wellbeing. The intricate etiology of hyperpigmentation and our evolving comprehension of its underlying mechanisms underscore the need for robust animal models. Zebrafish, renow...

Pruritus is the most common symptom of dermatological disorders, and prurigo nodularis (PN) is notorious for intractable and severe itching. Conventional treatments often yield disappointing outcomes, significantly affecting patients’ quality of life and psychological well-being. The pathogenesis of PN is associated with a self-sustained “itch-scra...

Janus kinase (JAK) inhibitors have heralded a paradigm shift in the management of immune-mediated diseases. While their efficacy is well-established, the safety concerns associated with these agents, particularly regarding thromboembolic events (TE), remain a focus of extensive research and clinical scrutiny. This comprehensive literature review em...

Introduction: The 2019 Coronavirus Disease (COVID-19) is a respiratory tract infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that spread rapidly worldwide through human-to-human transmission. Skin is one of the target organs that involvement in adults and children affected by the novel coronavirus SARS-CoV-2. Despit...

Background Chronic inducible urticaria (CIndU) is a subtype of chronic urticaria (CU) which require specific physical or non‐physical triggers to occur. They may be isolated or may coexist with chronic spontaneous urticaria (CSU). Despite their frequent appearance in dermatology clinics, there is scarce information on the distinguishing features am...

Background and Objectives: Gramicidin, a bactericidal antibiotic used in dermatology and ophthalmology, has recently garnered attention for its inhibitory actions against cancer cell growth. However, the effects of gramicidin on ovarian cancer cells and the underlying mechanisms are still poorly understood. We aimed to elucidate the anticancer effi...

Objective: Skin diseases constitute a widespread health concern, and the application of machine learning and deep learning algorithms has been instrumental in improving diagnostic accuracy and treatment effectiveness. This paper aims to provide a comprehensive review of the existing research on the utilization of machine learning and deep learning...

Scientific and technological progress has been produced by the Western Congress during the late 1990s of many ethical and social problems, which led to a new ethical idea that seeks to find rules and standards that regulate and guide application practices in various sciences, this being expressed in the concept of ethics from their classic concepts...

Background: Pembrolizumab monotherapy for non-small-cell lung cancer (NSCLC) expressing PD-L1 ≥ 50% doubles five-year survival rates compared to chemotherapy. However, immune-related adverse events (irAEs) can cause severe, long-term toxicity necessitating high-dose steroids and/or treatment cessation. Interestingly, patients experiencing irAEs dem...

is missing (Short communication)

The global prevalence of COVID-19 has necessitated the use of personal protective equipment, particularly face masks, amongst healthcare workers (HCWs). However, extended face mask usage has led to adverse health effects. This cross-sectional study investigates the relationship between prolonged surgical mask-wearing and the development of adverse...

Cocoa butter is very popular as an ingredient in cosmetic products. However, cosmetic cocoa butter is often offered in food quality, which tightens the market supply. At the same time, large parts of the cocoa crop are discarded due to diseases, even though the plant produces particularly interesting ingredients while combating diseases. These ingr...

Viral skin infections pose a significant health concern worldwide, causing discomfort, pain, and potential complications. The development of effective treatments for these infections is crucial in minimizing their impact on individuals’ quality of life. In recent years, there has been growing interest in the potential use of copper nanoparticles as...

Objectives: Investigate whether there is any association between the levels of vitamin D in the blood and the seriousness of psoriasis or its development. Methods: The study is characterized as observational, retrospective, composed of 40 patients with psoriasis who had serum vitamin D levels, who underwent clinical care at a dermatology outpatient...

Purpose of Review JAK inhibitors (JAKis) are a novel class of therapeutics that have shown great promise in dermatology. This review provides an overview of the role of JAKis in inpatient dermatology and highlights their potential for future applications. Recent Findings The impact of JAKis on a range of inflammatory signals, in combination with a...

Background: Skin diseases are diverse in various communities. They could be a major burden, affect the quality of life of individuals and cause increase in morbidity. Knowledge of the prevalent skin lesions will enable individuals and government to engage in health planning, prevention and allocation of resources. Objective: To examine the spectrum...

Background and Objectives: The assessment of sexual dysfunction among psoriatic patients still remains a great diagnostic difficulty due to its subjective and embarrassing character. Various questionnaires have been used to assess sexual dysfunctions associated with skin conditions; however, none of them have been approved as a gold standard. The a...

Tungiasis is a highly neglected tropical skin disease caused by the sand flea, Tunga penetrans. The flea burrows into the skin inducing a strong inflammatory response, leading to chronic pain and discomfort with potential impacts on quality of life. Few countries implement control efforts and there are few data on the impact of the disease to suppo...

This case describes a patient with known mantle cell lymphoma without cutaneous involvement presenting with a diffuse morbilliform rash during an inpatient admission for bacterial pneumonia. The patient was thought to have a hypersensitivity to antibiotics but failed to improve after the offending agents were stopped. A skin biopsy revealed metasta...

Visual clinical diagnosis of dermatoses in people of color (PoC) is a considerable challenge in daily clinical practice and a potential cause of misdiagnosis in this patient cohort. The study aimed to determine the difference in visual diagnostic skills of dermatologists practicing in Germany in patients with light skin (Ls) and patients with skin...

O objetivo deste estudo é examinar as competências profissionais que os enfermeiros possuem e empregam no mercado de trabalho da dermatologia e estética. A pesquisa foi realizada por meio de buscas em bases de dados científicas, como LILACS, SciELO e Google Acadêmico. Os filtros aplicados garantiram que os resultados incluíssem apenas trabalhos com...

The COVID-19 pandemic notably influenced the transmission of infectious diseases across various age groups. In this study, we assessed its impact on pediatric acute conjunctivitis trends in southern Israel. We analyzed acute conjunctivitis diagnoses from 2017 to 2022, categorizing them into pre-lockdown, lockdown, and post-lockdown intervals. A con...

Melasma is a common skin disorder of acquired hyperpigmentation that appears commonly on the face. Although asymptomatic, melasma causes psychosocial and emotional distress. This study aimed to assess melasma’s severity on people with darker skin types, evaluate the effects of melasma on the quality of life (QoL), and establish QoL predictors in af...

Background The developments in cosmetic sciences and technologies have generated a gap between the cosmetics and their users. Users including regular customers, clinicians, industry personnel, researchers, testing agencies, beauty salon workers, and mass media hardly possess the ability to distinguish truth from falsehood. The gap remained as one m...

Background Skin manifestations’ true prognostic value, and clinical and epidemiological pictures in SARS‐CoV‐2 infection in African populations are poorly described and understudied. More familiarity with COVID‐19 cutaneous manifestations may aid in early clinical diagnosis or guide prognosis. Methods In this literature review, we looked for poten...

Despite disproportionate mortality rates for Black skin cancer patients, medical education and practice guidelines center White bodies and fair skin. How did dark skin become such a deadly dermatological blind spot?

Widespread “lockdowns” during the COVID pandemic in 2020–2021 restricted medical students’ access to patients. We used a scoping review with exploratory thematic synthesis to examine how reports of digital clinical teaching during the first year of the COVID pandemic could inform digital clinical teaching in the post-pandemic world. We looked at st...

A 6‐month‐old female Labrador Retriever mix rescued by a local shelter developed respiratory distress and later became tetraplegic. After transferring to a specialty centre, diagnostic imaging (CT and MRI) revealed spina bifida at C3 and dermoid sinuses at the level of C3 and T1. Surgery was performed to remove the dermoid sinuses. The dog was plac...

Excessive epidermal hyperkeratosis in acral areas is a common occurrence in dermatology practice, with a notable prevalence of approximately 65% in the elderly, especially in plantar lesions. Hyperkeratosis, characterized by thickening of the stratum corneum, can have various causes, including chronic physical or chemical factors, genetic predispos...

BACKGROUND Pressure injury develops due to sustained pressure at the bony prominence of the skin and tissues. Geriatric patients often have multiple comorbidities, predisposing them to pressure injury. Data on the characteristics of the geriatric with pressure injuries are still limited. This study aimed to report the characteristics of geriatric p...

La industria cinematográfica utiliza hallazgos dermatológicos para ayudar a los espectadores a diferenciar entre héroes y villanos. Este estudio buscó determinar si existe una asociación significativa entre la presencia de vello facial y el tipo de carácter. Se analizaron los 10 mejores héroes y villanos masculinos de la lista de los 100 mejores hé...

Introduction Psoriasis (PsO) is a chronic inflammatory disease of the skin. While skin clearance, as measured by the Psoriasis Area and Severity Index (PASI), is a clinical goal, PsO patients also suffer from reduced health-related quality of life (HRQoL). In the Phase 3 VOYAGE 1 trial, guselkumab (GUS) demonstrated improvements on patient reported...

Introduction: There have been no large-scale studies looking at the efficacy and safety of methotrexate. Prior research by our team investigated whether certain monitoring practices were associated with lab abnormalities resulting in clinically relevant events (CREs) within the first 90 days of methotrexate treatment and concluded that dermatologis...

Background: Proper wound care is important for improving healing outcomes and minimizing long-term effects of scar formation. Selection of appropriate care may be challenging for individuals due to overabundance of product selection, and conflicting evidence on common wound care products, which may pose a risk for delayed wound healing. Objective:...

Background: Psoriasis is an inflammatory disease for which the implications and repercussions go far beyond the skin. Psoriasis patients suffer not only due to its skin manifestations and related symptoms but also because of comorbidities and a huge emotional impact. Objective: The objective of this study was to investigate chronotype and sleep qua...

Introdução: A Necrólise Epidérmica Tóxica (NET) é uma emergência dermatológica caracterizada por necrólise epidérmica generalizada, causando descamação da pele, que se torna susceptível a infecções graves. Apresenta acometimento multissistêmico, com alta morbimortalidade. O manejo da NET é multifacetado, e começa com a identificação e retirada do a...

Hydroxyurea is a cytotoxic drug that has been used for decades for the treatment of various entities, mostly hematologic, especially polycythemia vera. Its side effects are varied, including dermatological ones, ranging from skin xerosis to hyperpigmentation, lesions like dermatomyositis and shows even a relationship with premalignant processes (ac...

Resumo Introdução Queixas dermatológicas são frequentes e em sua maioria são avaliadas por médicos não especialistas. Objetivo Analisar a proporção de pacientes encaminhados para dermatologia que poderiam ter sido tratados na Atenção Primária à Saúde e o grau de concordância entre o diagnóstico de encaminhamento do médico da Atenção Primária à Saúd...

Leishmaniasis poses a diagnostic challenge due to its resemblance to many dermatologic conditions. As the incidence of Leishmaniasis has increased in the United States due to a rise in world travel it is imperative for healthcare providers, especially dermatologists, to recognize and properly diagnose Leishmaniasis. In this case report, we present...

Dermatology is huge science with many diseases and new variants daily discovered & and hundred of journals and archives about thousands of unique cases . But till now if you google for index for dermatology diseaes, you won't find any , so i got idea of creating first index of skin diseaes alphabeticaly ordered and contain whole names of diseases...

Introdução: O câncer de pele corresponde a 33% de todos os diagnósticos de neoplasia no Brasil. O início da doença pode ocorrer por múltiplas causas, sendo a exposição solar exagerada e sem medidas protetivas um grande fator determinante para o aparecimento da neoplasia. Fatores como cor da pele, horário e tempo de exposição ao sol podem contribuir...

Recent studies showed that antimicrobial peptides (AMPs) are essential in the pathogenesis of acne vulgaris. This study aims to investigate serum catestatin levels, one of the AMPs, in acne vulgaris patients and focuses on the change in serum levels after systemic isotretinoin therapy. 101 acne vulgaris patients and 28 healthy controls were include...

This research paper describes the formulation of a hybrid lotion, combining Hypericum perforatum-Q and Calendula officinalis-Q, using a precise and defined proportion. The study focuses on ensuring the quality and consistency of the lotion through rigorous quality control measures, including High-Performance Thin-Layer Chromatography (HPTLC) and UV...

Hyperimmunoglobulin E syndrome (HIES), also known as Job's syndrome, is a rare primary immunodeficiency disorder affecting both the cellular and humoral immune systems. It can be classified as autosomal dominant (AD HIES) or autosomal recessive (AR HIES) based on genetic mutations in the STAT3 or DOCK8 genes, respectively. Clinically, patients with...

Acneiform eruptions occur frequently and early in patients on epidermal growth factor receptor inhibitors (EGFRi). Identification of baseline patient risk factors would prompt earlier referral to dermatology to optimize prevention and man- agement. The primary objective of this retrospective study is to determine the association between clinical an...

This study was conducted to evaluates the immunological parameter IL-17) associated with development of dermatophyte infection. The study was carried out in the period beginning of December 2022 to end of June 2023.This study has been done at the Al-Hilla Teaching Hospital, Dermatology Unit, Babylon Government; ages range between 1 to 50 years in m...

Prolonged COVID is a persistent condition following the initial COVID-19 infection, which is characterized by a variety of symptoms that may include fatigue, muscle pain, sleep disturbances, “brain fog”, respiratory, cardiovascular, digestive, neurological and dermatological symptoms. Physical therapy has been identified as a crucial aspect of the...

Poster on a quality improvement project initiated to improve referral practices for acne vulgaris treatment to the specialist dermatology clinic

Several medical fields currently use platelet-rich plasma (PRP). PRP's use in dermatology has recently attracted more attention. It is utilised for a variety of purposes, including alopecia, skin rejuvenation, and scar revision, wound healing, and tissue regeneration. A component of the plasma fraction of autologous blood with a platelet concentrat...

Introduction. Vitiligo is an acquired autoimmune disease associated with high psychosocial burden. As novel treatments are being developed in clinical trials, assessing vitiligo disease burden extends beyond physical manifestations. Including quality of life (QoL) measures in vitiligo clinical trials can better capture disease-specific psychosocial...

Some people react abnormally when exposed to sunlight by getting easily burned or develop a rash. When testing a patient’s level of photosensitivity in the clinic, the UVR dose to provoke erythema is determined by the minimal erythema dose (MED) test. Subsequently, a photoprovocation test is performed to detect abnormal skin reactions by daily expo...

The purpose of this study is to determine the efficacy and safety of 595-nm pulsed dye laser (PDL) for port wine stains (PWS) treatment in Vietnamese patients. The study also analyzed the association between the response to treatment and the characteristics of patients and treatment regimens. Parallelly, the study contributed to further optimal tre...

Introduction: There are few long-term effectiveness and safety data for dupilumab in the treatment of atopic dermatitis (AD). The aim of this study was to evaluate efficacy and safety of dupilumab for up to three years after treatment initiation. Materials and Methods: We collected data from patients ≥ 12 years with severe AD who started dupilumab...

Background Patients with lesions suspicious for skin cancer often present to primary care physicians (PCPs), who may have limited training in skin cancer diagnosis. Objective To measure the impact of an adjunctive handheld device for PCPs that employs elastic scattering spectroscopy (ESS) on the diagnosis and management of skin cancer. Methods Fi...

Background Psoriasis is a chronic and refractory skin disease. The emergence of biologics provides more options for the treatment of psoriasis, but the COVID-19 pandemic poses challenges for the management of psoriasis. Objectives The purpose of this study was to investigate the effect of different biologics on the stabilization of psoriasis durin...

Introduction: The number of distractors needed for high quality multiple choice questions (MCQs) will be determined by many factors. These include firstly whether English language is their mother tongue or a foreign language; secondly whether the instructors who construct the questions are experts or not; thirdly the time spent on constructing the...

Background: The use of skin lightening products has been a widely spread practice, over the past decade, in Sudan, as well as worldwide. This is probably due to the unfortunate social and cultural pressure that is placed upon women to believe that being fair skinned is the epitome of beauty. Methodology: This study was an observational cross-sectio...

Introduction: Tinea favosa, a dermatophytic infection primarily caused by Trichophyton schoenleinii, remains a notable dermatological concern. It is characterized clinically by yellowish cup-shaped crusts on the scalp, and these lesions can result in scarring or non-scarring alopecia. Case Presentation: Three cases of severe tinea favosa transmitte...

There are no obvious clinical signs of a silent disease until it causes irreversible damage. As computerized technologies become more common for early detection of ailments, severity can be minimized. In order to minimize the severity of ailments, computerized technologies are being used more and more commonly for early detection through internet o...

Biologic disease-modifying antirheumatic drugs (bDMARDs) and particularly tumor necrosis factor inhibitors (TNFi) have dramatically changed the natural history of psoriatic arthritis (PsA), making complete clinical remission possible in most patients. However, TNFi drugs are not without potential adverse effects such as increased infectious risk. I...

Atopic dermatitis is a prominent dermatological condition in children that frequently affects their lifestyle. Conventional treatments frequently prove inadequate, necessitating the use of biological agents like Lebrikizumab to address the condition at its core pathophysiological level. The introduction of biologic drugs has broadened the spectrum...

Skin toxicities are very common in patients undergoing cancer treatment and have been found to occur with all types of cancer therapeutic interventions (cytotoxic chemotherapy, targeted therapies, immunotherapy, and radiotherapy). Further, skin toxicities can lead to interruption or even discontinuation of anticancer treatment in some patients, tra...

The brick manufacturing sector in Bangladesh is experiencing rapid growth, leading to notable environmental and health concerns. The primary objective of this research is to examine the Savar Upazila, a region of significant economic significance owing to its favorable brick manufacturing conditions and proximity to Dhaka city. Brick kilns, among o...

Systemic lupus erythematosus (SLE) is an autoimmune disease associated with hyperactive innate and adaptive immune systems that cause dermatological, cardiovascular, renal, and neuropsychiatric problems in patients. SLE's multifactorial nature and complex pathogenesis present significant challenges in its clinical classification. In addition, unpre...

Background: Skin cancers (SCs) arise due to the proliferation of atypical cells that have the potential to infiltrate or metastasize to different areas of the body. There is a lack of understanding regarding the country-based collaborations among authors (CBCA) and article themes on SCs. A clustering algorithm capable of categorizing CBCA and arti...