Dermatology - Science topic

Human skin is a physical and biochemical barrier that protects the internal body from the external environment. Throughout a person’s life, the skin undergoes both intrinsic and extrinsic aging, leading to microscopic and macroscopic changes in its morphology. In addition, the repair processes slow with aging, making the older population more susce...

Background The Family Vitiligo Impact Scale (FVIS) is the first reliable and valid instrument to evaluate the psychological and social impact on family members with vitiligo. However, the FVIS has not yet been validated in China. Objective This study aimed to adapt the FVIS across cultures and utilize a cross-sectional design to validate its relia...

Objetivo: descrever as ações do Núcleo de Telessaúde na Universidade Federal dos Vales do Jequitinhonha e Mucuri. Métodos: trata-se de um estudo retrospectivo e descritivo, com abordagem quantitativa. Foram analisados os registros documentais do Núcleo de Telessaúde, que tem como base o projeto Saúde Digital Móvel, no período de agosto de 2022 a ma...

Background The efficacy and safety of dupilumab in patients with refractory prurigo nodularis (PN) is well established in clinical trials, but there is a lack of multicenter data regarding its effectiveness and safety in real‐world settings. Methods Patients with moderate‐to‐severe PN who initiated dupilumab treatment between July 2023 and January...

Background Childhood is a crucial period that shapes a person’s growth and development. For orphans, a lack of familial support affects their upbringing, making orphanages crucial for care. Children living in orphanage centers are vulnerable to several conditions, including dermatological disorders, due to factors such as malnutrition, overcrowding...

Aim and objectives: The goal of present work is to record the increase in the rate of lichen planus in Iraqi people and to study the effectivity and safety of colchicine as a therapeutic option among lichen planus patients. Materials and methods: This study in a design of a cross-sectional, 92 patients of lichen planus, were enrolled from those pat...

This study aimed to analyze the effectiveness of using an antivenom serum (AVS) premedication protocol to prevent early adverse reactions (EAR). This is a cohort study conducted with data from the Londrina Information and Toxicological Assistance Center (CIATox-Londrina) at the University Hospital of the State University of Londrina (HU-UEL), which...

Racial bias in medicine, particularly in dermatology, presents significant ethical and clinical challenges. It often results from the underrepresentation of darker skin tones in training datasets for machine learning models. While efforts to address bias in dermatology have focused on improving dataset diversity and mitigating disparities in discri...

Background Dermatological health-related quality of life (HRQoL) in solid organ transplant recipients (SOTRs), often affected by skin cancer, has been insufficiently explored. This study aimed to evaluate the impact of skin cancer on quality of life (QoL) in SOTRs and to compare HRQoL measures between SOTRs with and without skin cancer. Methods Th...

Background Non-fatal burns impact millions annually, are difficult to treat, and reduce quality of life. Laser technology offers a promising approach for improving scar outcomes, in particular, laser-assisted drug delivery (LADD), which has shown effective results in various dermatological conditions. The aim of this study is to evaluate advanced l...

Knowledge on the effect of different nicotine consumption modalities on dermatologic surgical outcomes is limited, with conflicting conclusions. Cigarette smoking is known to adversely affect outcomes, but the impact of other nicotine consumption modalities like cigars, smokeless tobacco, and nicotine replacement therapy (NRT) is less understood. O...

Zusammenfassung Hintergrund Zahlreiche Patient:innen, die in eine Klinik stationär aufgenommen werden, weisen nebenbefundlich Hautveränderungen auf. Am Universitätsklinikum Leipzig AöR wurden in einem Jahr ca. 800 Konsile durch die Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie beantwortet. Ziel der Arbeit Es erfolgten die I...

Since the introduction of CO2 fractional laser in dermatology, multiple clinical evidences have shown its effectiveness in treating alopecia areata(AA). However, the extent of efficacy remains under-researched, with a lack of extensive and large-scale comparisons, which is a topic of global discussion. We present a case of a 13-year-old male child...

Malignant melanoma (MM) is a malignant tumor, resulting from mutations in melanocytes of the skin and mucous membranes. Its mortality rate accounts for 90% of all dermatologic tumor mortality. Traditional treatments such as surgery, chemotherapy, and radiotherapy are unable to achieve the expected results due to MM’s low sensitivity, high drug resi...

Can black soldier fly (BSF) larvae be a protein substitute for managing adverse food reactions (AFRs) in dogs, specifically those with dermatitis? We evaluated BSF larvae’s safety, tolerance, and effectiveness as a novel protein source in dogs with AFRs. Sixteen dogs, including eight healthy controls and eight diagnosed with AFRs, were fed a diet c...

Objective: To highlight the importance of early recognition of hypopigmented mycosis fungoides (HMF) in cases of cutaneous hypochromia in children, with a view to an effective diagnostic and therapeutic approach. Case description: Two cases of HMF in children are reported. The first case involves an eight-year-old boy with hypochromic macules on th...

Purpose of Review Despite global incidence, considerable morbidity, and diverse triggers, CU is poorly characterized amongst diverse African populations. This systematic review aims to describe available African CU studies and unmet needs. Recent Findings Overall 221 publications were screened and 29 were eligible for full review. These publicatio...

A growing number of skin laser treatments have rapidly evolved and increased their role in the field of dermatology, laser treatment is considered to be used for a variety of pigmentary dermatosis as well as aesthetic problems. The standardized assessment of laser treatment efficacy is crucial for the interpretation and comparison of studies relate...

Tattoos are widespread in the population. Tattoo inks, which contain a variety of ingredients among them hazardous compounds such as polyaromatic hydrocarbons, heavy metals and nanoparticles and that are made for injection into the skin, are not dermatologically tested. New testing systems for evaluation of biocompatibility of tattoo inks as compos...

The “costal fringe” refers to a linear arrangement of venous telangiectasias distributed along the anterolateral costal margins. The costal fringe is typically observed in older adults, although it has also been reported in younger patients. On the other hand, linear telangiectasias, arranged in a broad, crescent-shaped distribution across the ches...

Objectives To examine the rate of skin color reporting in randomized controlled trials (RCTs) involving melanoma in the top ten highest dermatology journals by impact factor over the past four decades. Methods A systematic review of RCTs involving melanoma within the top ten dermatology journals, as determined by impact factor, was conducted from...

Introduction Anthropology is the scientific exploration of the human body morphology. The present study aims to establish the anthropometric norms among young Persian ethnic women and compare them with golden proportion, a mathematical formula in facial esthetics. Methods This cross‐sectional study was performed on Persian women between July 2020...

Introduction: Diagnostic error of the cutaneous sinus tract is typically unusual. An individual with a cutaneous sinus seeks initial medical attention before coming to the dentist because its appearance resembles a variety of dermatological conditions. Any cutaneous sinus of odontogenic origin emerges when the harmful by-products of necrosed dental...

Background. Over the last decade, the incidence of atopic dermatitis (AD) has increased significantly and reaches from 5 to 20 % in different countries, which is obviously related to the improvement of the diagnostic algorithm. According to modern data, the course of AD has significantly worsened despite the improvement of comprehensive treatment m...

Patients with progressing facial vitiligo who had been treated with upadacitinib, 308 nm excimer light and upadacitinib combined with 308 nm excimer light were selected for retrospective analysis and comparison of their efficacy and safety. Efficacy was evaluated using the Vitiligo Area Severity Index (VASI) and Dermatology Life Quality Index (DLQI...

Introduction Acne vulgaris, a prevalent dermatological condition, often results in long-term complications such as scarring and hyperpigmentation. While extensive research has focused on treatment modalities, there is a notable gap in understanding the factors contributing to the development of acne scarring and post-inflammatory hyperpigmentation...

Introduction: Following an asymptomatic or mildly symptomatic coronavirus disease (COVID‑19), otherwise healthy children may develop serious manifestations in the form of cardiac, neurological, respiratory, gastrointestinal, and dermatologic dysfunction. Many such cases were being observed in Odisha, an eastern state of India, and have been reporte...

There are a substantial number of published systematic reviews and meta-analyses on the use of the Dermatology Life Quality Index (DLQI). Of the 3,776 results found in PubMed by searching for “DLQI” or "dermatology life quality index" (filtered for “systematic review” or “meta-analysis”), 142 are categorised as systematic reviews, and 89 as meta-an...

Background Physicians are responsible for most decisions related to resource allocation and healthcare expenditures, and should consider cost in their decision-making approach. Objective To measure cost consciousness among dermatologists, evaluate their understanding of cost-related concepts, and explore what prevents them from factoring cost into...

Alysicarpus naikianus Pokle is an endemic species of the genus Alysicarpus in the subfamily Papilionoideae, tribe Desmodieae, of the Leguminosae family. Described in 1999, this species was initially known from limited collections at three localities in Maharashtra, India. Recent floristic surveys, particularly in the hilly areas of the Eastern Ghat...

Background In a recent prospective, multicenter, two-arm randomized controlled trial (RCT), we demonstrated that adjunctive reflectance confocal microscopy (RCM) in routine clinical practice provides clinical benefits, including safe melanoma detection and a 43.3% reduction in the number needed to excise (NNE). Methods A cost–benefit analysis was...

Background Dupilumab, inhibiting interleukin 4 and 13, is the first monoclonal antibody licensed for atopic dermatitis (AD) since 6 months of age. Objectives The study describes the patients' profile, the effectiveness and safety in real life of dupilumab in adolescents with moderate‐severe AD and children with severe AD. Methods National, multic...

Results from randomized controlled trials of upadacitinib, a Janus kinase (JAK) inhibitor, have led to its approval for the treatment of moderate-to-severe atopic dermatitis (AD) in patients aged ≥ 12 years. The aim of this study was to report the effectiveness and safety of upadacitinib in real-world settings over a period of 96 weeks. This retros...

The impact of atopic dermatitis (AD) on daily life and different levels of quality of life (QOL) according to AD severity has not been fully elucidated. This study aimed to assess QOL in relation to the AD severity in Japan. This observational study used anonymized data of health insurance association members and their families registered to a mobi...

Pregnancy-associated melanoma affects both maternal and fetal health. This study aims to demonstrate how a specialized center and a multidisciplinary approach can provide the best outcomes. From January 2006 to September 2023, a bicentric observational study was conducted at the Plastic Surgery Department of Policlinico Umberto I, Sapienza Universi...

O Brasil registrou 112.090 casos de hanseníase de 2020 a 2024, sendo o nordeste brasileiro, a região com maior número de notificações, totalizando 47.290 diagnósticos, seguida da região centro oeste, com 25.059 infectados pelo Mycobacterium leprae. O município de Petrolina/PE, localizado na bacia hidrográfica do submédio do Rio São Francisco, no se...

AI algorithms have become valuable in aiding professionals in healthcare. The increasing confidence obtained by these models is helpful in critical decision demands. In clinical dermatology, classification models can detect malignant lesions on patients' skin using only RGB images as input. However, most learning-based methods employ data acquired...

Metformin, a widely used first-line treatment for type 2 diabetes mellitus (T2DM), is known for its efficacy and safety profile. While gastrointestinal disturbances are the most commonly reported with metformin use, dermatologic reactions, particularly severe ones, are rare and underrecognized. We present a case of a 45-year-old male with a history...

Introduction: Acut idiopathic urticaria is a common dermatologic condition that can significantly impact a patient's quality of life. Studies suggest various factors, including allergic and non-allergic triggers, play a role in the disease's development. However, the effects of lifestyle factors such as food consumption on disease activity and skin...

OBJECTIVE This study investigated whether the behavior profiles of cats with inflammatory gastrointestinal or skin diseases differ from those of healthy cats. METHODS We identified adult cats within the patient database at the University of Pennsylvania’s veterinary hospital that had been diagnosed with inflammatory gastrointestinal (n = 22) or sk...

Background Aging reduces the production of hyaluronic acid (HA) in the skin, leading to wrinkles and sagging. HA‐based skincare products are being studied to improve skin quality. This systematic review and meta‐analysis aimed to compare the effectiveness of HA‐based injectable products for reducing wrinkles and enhancing skin elasticity, hydration...

Simple Summary Recent advancements in systemic therapies for genitourinary cancers, including immunotherapies, targeted therapies, and antibody-drug conjugates, have improved patient outcomes but have also introduced new skin-related side effects. These skin toxicities vary widely in presentation, severity, and onset, ranging from mild rashes to se...

Atopic dermatitis (AD) may be associated with other diseases, which could impact the patient's overall health. The aim of this study was to assess the comorbidities observed in patients diagnosed with AD and psoriasis compared to healthy patients. Patients over 18 years old were recruited using the medical databases of dermatology clinics. Initiall...

INTRODUCTION. Climate change has a significant impact on human health, particularly with regard to the respiratory, immune and cardiovascular systems. In addition, these changes have a significant impact on mental health and dermatological diseases. The main drivers of these health changes are increasing temperature, humidity, expansion of the ozon...

Photodynamic therapy (PDT) involves the topical application of a photosensitizer and its activation by visible light, leading to the generation of protoporphyrin IX (PpIX) and reactive oxygen species. Daylight photodynamic therapy (dPDT), a variant utilizing natural sunlight as the energy source, enhances procedural flexibility by eliminating the n...

Melanoma is an aggressive and lethal type of skin cancer for which early detection can be lifesaving. The recent progress in the diagnostic methodologies has played a great role in early detection, thus considerably increasing the rate of their diagnosis. Dermoscopy enables one to visualize structures in the skin that are not easily visible to the...

Atopic dermatitis significantly impacts an individual’s life. Prior research has found positive correlations between the disease’s impact on daily quality of life, depression, and perceived stigmatization. However, the interaction of these variables in predicting depression levels in people with atopic dermatitis is currently not well understood. T...

Acne is a common dermatological condition affecting individuals of all races and ethnicities, with most cases occurring in teenagers and young adults. Patients in these age groups frequently turn to online platforms for guidance, relying on videos on social media platforms like TikTok. This study evaluated the top TikTok videos' content quality (DI...

In Phase 3, monotherapy trials, ADvocate1 (NCT04146363) and ADvocate2 (NCT04178967), Week 16-responders treated with lebrikizumab (LEB) every 2 weeks (Q2W) and every 4 weeks (Q4W) demonstrated extended maintenance of deep response in skin clearance and itch improvement. In this post hoc analysis of ADvocate1/-2, among LEB responders (defined by ach...

The use of immunotherapy is an emerging treatment option for advanced malignancies. Cutaneous adverse events following cancer immunotherapy are well-documented in the literature. The rarer cutaneous adverse effects are less characterized, including eruptive keratoacanthomas (KA). Despite surgical excision remaining the treatment of choice for KA, s...

Anogenital warts (AGW) including multiple types of human papillomavirus (HPV) are prevalent. In this context, oncogenic HPV infection leads to anogenital cancers and the lesion is more persistent. Several research on AGW therapy with measles, mumps, and rubella (MMR) vaccine injections have been successful without adverse effects. However, the effe...

Introduction: Psoriasis (PsO) is an inflammatory disease that affects 3.2% of the US adult population (1). Patients treated with biological agents show higher treatment satisfaction over those treated with oral therapy, phototherapy and topical therapy (1). Ixekizumab has proven to be effective in treating moderate-to-severe plaque PsO in clinical...

Introduction: Rock climbing is a popular activity that poses various injury risks, including falls, equipment failures, physical stress from climbing, and contact with falling objects. We aimed to quantify emergent dermatological injuries and conditions Methods: We used the NEISS database that collates data from over 100 emergency rooms and applied...

Background: Increasing evidence indicates that skin disorders may contribute to an increased risk of autism spectrum disorder (ASD). They can affect the quality of life, and they have an impact on social isolation, behavioral problems, cognitive scores, and some subscales of ASD. Methods: This study was an online questionnaire-based, observational,...

Introduction Psoriasis is a chronic inflammatory skin disorder affecting millions worldwide. Dermoscopy and proximal nailfold capillaroscopy have emerged as valuable tools for understanding the pathophysiology and treatment response of psoriasis lesions. Objectives This study aimed to contribute to the limited literature on using dermoscopic findi...

Vitiligo is a depigmentation disorder characterized by the distinct macules or depigmented patches, which are often asymptomatic. Age and geographic location have an impact on the prevalence of vitiligo. This condition affects 0.5-2% of the global population and is caused by a combination of factors, including clinical symptoms and therapeutic outc...

Introduction: Atopic dermatitis (AD) is a chronic, relapsing, heterogeneous inflammatory disorder. After a flare-up, the affected skin may have areas of post-inflammatory hyper- or hypo-pigmentation (PIH). A new scale, the PDCA-Derm™, assesses PIH by comparing post-inflammatory lesions to adjacent normal skin. This single-item clinician-reported ou...

The development of vision-language models (VLMs) is driven by large-scale and diverse multimodal datasets. However, progress toward generalist biomedical VLMs is limited by the lack of annotated, publicly accessible datasets across biology and medicine. Existing efforts are restricted to narrow domains, missing the full diversity of biomedical know...

Objective: The aim of this study is to assess the skin changes that may occur in people as a result of frequent hand washing with topical antiseptics to protect themselves during COVID-19 pandemic. Methods: This is a cross sectional descriptive study done in Alkadhimia Teaching Hospital in Baghdad during COVID-19 pandemic from the period 1st of Nov...

Dermatology diseases index fourth edition is first largest and most updated index of skin diseases in the world containing more than 5000 names ,and this index not just index so read to discover https://www.mediafire.com/folder/4sir5u7xu9rs2/Index

Background: Vitiligo is a pigmentation disorder that impacts approximately 0.5% to 2% of the global population. Growing interest surrounds the comorbidities associated with vitiligo. This study aimed to describe the socio-demographic characteristics of the patients with vitiligo in Aragón (Spain) and to investigate their associated comorbidities. M...

Skin cancer is one of the most common cancers worldwide where early detection is crucial for effectively diagnosing and treatment. Traditional diagnostic methods largely depend on dermoscopic or skin lesion image analysis. However, they are limited by the clinician’s expertise and primarily rely on image data. While most of the studies focus on imp...

Pityriasis rosea (PR) is a prevalent dermatological condition characterized by a distinctive herald patch, followed by secondary eruptions, often forming a “Christmas tree” pattern on the trunk. Despite its recognizable clinical presentation, the etiology of PR remains uncertain, with hypotheses pointing to both infectious and noninfectious origins...

Background Atopic dermatitis (AD) is a chronic, pruritic, and inflammatory dermatosis seen in individuals with an atopic predisposition. This study aimed to examine the immunoreactivity of spexin and TRPM2 in skin samples from patients with AD and MF lesions using immunohistochemical methods. Materials and methods The study utilized a total of 60...

Introduction In recent years, the field of aesthetic dermatology has witnessed a surge in demand for minimally invasive procedures aimed at rejuvenating aging skin. This study aims to address this demand by evaluating the effectiveness of the injectable gel in rejuvenating aging skin, particularly by targeting collagen regeneration and lifting effe...