Dermatitis - Science topic

Aims: The goal of this review is to give a complete update on atopic dermatitis (AD), including its causes, risk factors, symptoms, diagnosis, and treatment. It will focus on new treatments and future directions in personalised care. Review Article Mahmood et al.; Asian J. 68 Study Design: This is a narrative review of the most recent research on t...

Objective The incidence of primary tracheal neoplasm is extremely rare. Squamous cell carcinoma (SCC) is the most prevalent histological type of tracheal malignancy. Postoperative adjuvant radiotherapy can be considered as a curative management option. However, there are limited data available on the use of radiotherapy or concurrent chemoradiother...

Purpose This multicenter retrospective study assessed the real-world effectiveness and safety of upadacitinib in adults with moderate-to-severe atopic dermatitis across eight centers in central Italy. Materials and methods A total of 150 patients received upadacitinib 15 mg or 30 mg daily as monotherapy. Clinical outcomes were evaluated up to 104...

Topical molecular targeted therapies have recently emerged for the treatment of atopic dermatitis (AD), but their efficacy and safety, particularly in children, remain underexplored. This systematic review and meta‐analysis aim to evaluate the efficacy and safety of topical targeted therapies in children with AD. We conducted a comprehensive search...

Introduction Allergists and dermatologists often take different approaches to caring for pediatric patients with atopic dermatitis (AD). Methods A retrospective chart review was performed on patients <18 years old treated for AD within the University of Virginia health system from 2015 to 2020. Data were collected on patient and referring provider...

Asthma, allergic rhinitis, and atopic dermatitis are common, complex traits that are frequently co-morbid and have strong genetic correlation. However, the extent to which genome-wide genetic correlation between traits reflects shared causal variants or risk genes remains unclear. To address this question, we used functional fine-mapping. We genera...

Background No biological treatment has been approved for pediatric eosinophilic esophagitis (EoE) in France. For patients refractory to conventional treatments, although compassionate use of monoclonal antibodies has developed, experience remains limited. Methods We conducted a national multicenter study across French pediatric tertiary care cente...

Background Due to the inability of children with allergies to exhibit appropriate clinical symptoms, pediatricians often face the challenge of accurately diagnosing allergic diseases in children. Identifying the distribution of allergens is essential for the effective diagnosis and treatment of allergic diseases. Methods We investigated the distri...

Introduction and Purpose: This comprehensive review aims to synthesize and analyze the existing scientific literature concerning the multifaceted impact of forest bathing, also known as shinrin-yoku, on human health and overall well-being. We will delve into the historical origins of shinrin-yoku while also meticulously examining the specific healt...

Background Systemic corticosteroid use in type 2 inflammation-associated diseases including asthma, atopic dermatitis, allergic rhinitis, and chronic rhinosinusitis has been associated with adverse outcomes, and corticosteroid-sparing treatments are available. Objective Assess temporal changes in systemic corticosteroid use and the impact of type...

Background Type 2 inflammation plays a pivotal role in various allergic and inflammatory diseases, including chronic rhinosinusitis, asthma, atopic dermatitis, and eosinophilic esophagitis. Dupilumab is one of the emerging therapeutic targets that modulate the key mediators and cellular players involved in type 2 inflammation, aiming to improve the...

Dermatology encompasses a broad range of conditions, ranging from single-gene disorders to common complex disorders characterised by polygenic risk factors like psoriasis and atopic dermatitis. For clinicians, understanding the genetic basis of these conditions is essential for accurate diagnosis, effective management, and appropriate genetic couns...

Background Many skin disorders of the face have an inflammatory element, including atopic dermatitis, acne vulgaris, and rosacea. VYC‐12 is an injectable hyaluronic acid product with well‐established hydrating effects and potential anti‐inflammatory benefits. Aims To assess the utility of VYC‐12 for improving inflammatory skin conditions. Methods...

This chapter provides a comprehensive overview of phototherapy as a critical therapeutic option in managing atopic dermatitis (AD). AD is a chronic inflammatory skin condition characterized by a disrupted skin barrier and immune dysregulation, affecting patients’ quality of life significantly. Phototherapy, particularly narrowband UVB (NB-UVB) and...

Plain Language Summary This online survey looked at how individuals with alopecia areata (AA) experience their condition and its treatment in Finland. Alopecia areata is a chronic autoimmune condition that causes hair loss, often in patches, and can affect both the scalp and other areas of the body. It is not just a cosmetic issue but a disease tha...

Evaluating the real-world effectiveness, safety, and tolerability of targeted biologic and non-biologic therapies in patients with atopic dermatitis (AD) treated in routine clinical practice remains crucial. In this international, multicenter, retrospective, comparative study we aimed to evaluate the 52-week effectiveness, safety, and tolerability...

Seborrhoeic dermatitis is a chronic debilitating dermatosis manifesting as recurrent erythematous macules and plaques with a greasy scaly appearance on sebum-rich areas of the skin; especially the face. It occurs worldwide; peaking at puberty and infancy. The dermatosis has also been associated with chronic conditions like Parkinson’s disease and R...

Atopic dermatitis (AD) is a prevalent chronic inflammatory skin disorder, affecting 10%–20% of the population, characterized by dryness, intense itching, and recurrent rashes. The pathophysiology of AD is multifactorial, involving skin barrier dysfunction, immune dysregulation, genetic factors (such as filaggrin mutations), and environmental factor...

Purpose Epidermal growth factor receptor inhibitors (EGFRIs) and immune checkpoint inhibitors (ICIs) show promising efficacy in colorectal cancer and head and neck squamous cell carcinoma therapy, especially in combination. However, given the many cutaneous adverse effects (CAE) associated with each, there is concern for overlap and exacerbation of...

Achievement of stringent outcomes (e.g., ≥ 90% improvement from baseline in Eczema Area and Severity Index [EASI 90] or minimal-to-no itch on the Worst Pruritus Numerical Rating Scale [WP-NRS 0/1]) is associated with a substantial improvement in quality of life among patients with atopic dermatitis (AD). Using stringent outcomes, we evaluated the e...

Abstract: Artificial intelligence (AI) is rapidly transforming diagnostic approaches in different fields of medical sciences, demonstrating an emerging potential to revolutionize dermatopathology due to its capacity to process large amounts of data in the shortest possible time, both for diagnosis and research purposes. Different AI models have bee...

The association between cesarean delivery and childhood allergic diseases, such as atopic dermatitis, food allergy, and bronchial asthma, remains unclear, with limited evidence from Asian populations. We analyzed population-based data of 2,114 children born in Japan in 2010 from the Longitudinal Survey of Babies in the 21st Century, linked to the P...

Secondary eosinophilia has recently gained attention as a potential contributor to vascular pathologies, including aneurysms. This case report delves into the intricate relationship between secondary eosinophilia and cerebral aneurysms, a connection yet to be fully explored in medical literature. The case centers on a 31-year-old female who present...

Chronic eczema is a common chronic inflammatory skin disease, with a prevalence of 7.8% to 10.2% in China. It is characterized by skin itching, redness, swelling, exudation, and scaling, which severely affect the quality of life of patients. Modern medicine primarily uses hormonal drugs, antihistamines, and immunosuppressants for treatment. Althoug...

Contact dermatitis is an inflammatory disease characterised by skin redness and swelling, oozing of fluid or pus and pain, caused by direct skin contact with an irritant or allergen. Its prevalence has skyrocketed worldwide, probably because human skin is in daily contact with an increasing gamut of irritants and allergens, which should require sys...

Alopecia areata (AA) and atopic dermatitis (AD) are complex immune-mediated conditions that frequently coexist in pediatric patients, complicating treatment approaches. Upadacitinib, a selective JAK1 inhibitor, modulates both Th1 and Th2 pathways and is approved for AD in adolescents and adults. This study presents a case series of three adolescent...

Background: Aggressive squamous cell carcinoma (SCC) of the head and neck presents a therapeutic challenge due to its high recurrence and progression rates. While radiotherapy is a standard postoperative treatment, the addition of concurrent chemotherapy may enhance outcomes by improving locoregional control and overall survival. Cetuximab, an epid...

Background Durvalumab (D; anti-programmed cell death ligand 1 (PD-L1)) monotherapy or in combination with tremelimumab (T; anti-cytotoxic T lymphocyte antigen-4 (CTLA-4)) have demonstrated efficacy in advanced cancers. However, higher incidences of adverse events (AEs) and immune-mediated AEs (imAEs) were observed with D+T compared with D monothera...

Background. Cow’s milk allergy (CMA) is one of the most common food allergies in infancy, with prevalence estimates of 0.5–7.5% in high-income countries. Data from low- and middle-income regions remain limited, and the predominant immune mechanism (IgE or non-IgE mediated) may vary across populations. Objective. We aimed to determine the prevalence...

Tralokinumab, a human IgG4 monoclonal antibody that inhibits the IL-13 pathway, is approved for the treatment of atopic dermatitis. However, real-world data are lacking and are needed to inform its efficacy and safety in broader populations. This retrospective study reviewed the Eczema Area and Severity Index (EASI) and Dermatology Life Quality Ind...

Introduction The most common risk factors for ostomy complications include the cause of stoma emergence (cancer, inflammatory bowel diseases), the type of stoma, concomitant diseases, and stoma care during pre- and postoperative periods. Aim In this study, authors assessed the impact of stoma care and stoma site designation prior to surgery based...

Radiodermatitis (RD) is a major side effect after radiotherapy (RT). It has negative effect on patient’s quality of life. Recent studies have explored the use of photobiomodulation therapy (PBMT) in preventing or reducing the incidence of RD. The present study systematically reviews existing literature on PMBT with regards to protection against RD....

Psoriasis (Pso) and atopic dermatitis (AD) are chronic inflammatory skin diseases with distinct but also shared immunological features. Assessment of the feasibility of high content immunohistochemistry to identify distinct immune responses in skin biopsies from patients with chronic inflammatory skin diseases. While principal component analysis (P...

Background and Objectives: Psoriasis and atopic dermatitis (AD) are immune-mediated inflammatory diseases traditionally viewed as distinct. However, a subset of patients may present with overlapping features, leading to diagnostic and therapeutic challenges. This study aims to characterize the clinical, histopathological, and therapeutic features o...

Background Prurigo nodularis (PN), while rare, presents significant clinical challenges due to its diverse pathogenesis and presentation. Effective therapy recommendations for PN remain limited. Upadacitinib, an oral highly selective type 1 Janus-associated kinase (JAK, Intracellular tyrosine kinases that phosphorylate cytokine receptors). Inhibito...

The aim of the study here was to evaluate the association between expression of CD23 molecule on B-lymphocytes and the level of specific IgE to molecular components of birch, Bermuda grass, hazel pollen, timothy, and rye grass in atopic dermatitis (AD) patients (with and without dupilumab therapy). A total of 46 patients suffering from AD were incl...

Background Atopic dermatitis is a common chronic skin disease in children. Whether telomere length is associated with atopic dermatitis remains unclear. This population‐based case‐control study aimed to investigate the association between telomere length and atopic dermatitis in school‐age children. Methods In this cross‐sectional analysis, we inc...

QY201 is a dual inhibitor targeting Janus Kinase 1/Tyrosine Kinase 2, developed for the treatment of atopic dermatitis and other autoimmune diseases. The pharmacokinetics (PK), pharmacodynamics (PD), tolerability, and safety of QY201 were assessed in a randomized, double‐blind study in healthy subjects. Population PK and PD models were developed to...

Bu çalışma, metastatik renal hücreli karsinom (mRHK) tedavisinde tirozin kinaz inhibitörlerinin (TKİ) etkinlik ve yan etkilerini retrospektif olarak değerlendirmeyi amaçlamaktadır. mRHK, ileri evrede tanı konulan ve yaşam süresi beklentilerini sınırlayan bir kanser türüdür. Türkiye'de interferon alfa tedavisi geleneksel olarak birinci basamak tedav...

Purpose Understanding the treatment goals and preferences of young atopic dermatitis (AD) patients and their caregivers is crucial for enhancing patient-centered care. This study aims to identify these goals and preferences and explore heterogeneity among subgroups. Materials and methods A web-based survey was conducted among children (6–11 years)...

Background/Aim: To assess the efficacy of the wheat extract rigenase plus the antiseptic polyhexanide spray in preventing and reducing the incidence of grade 2-3 acute radiation-induced skin toxicity (RIST) in patients undergoing adjuvant hypo-fractionated radiotherapy to the breast for cancer. Patients and Methods: Three hundred and twenty-four pa...

To explore the incidence and risk factors for medical adhesive‐related skin injury (MARSI) in cancer patients in China, and to provide a basic framework for approaches designed to reduce the occurrence of MARSI and improve the management of its risk factors. PubMed, Web of Science, The Cochrane Library, EmBase, CNKI, VIP, Wanfang, and CBM were sear...

Purpose Skin health is deeply linked with the balance of resident bacteria, and a disturbance in this balance can readily cause skin problems. Sterilization with plasma treatment offers potential to improve symptoms in patients with acne vulgaris or atopic dermatitis. The aim of this study was to examine the antibacterial effect of plasma and analy...

Published in Acta Dermato-Venereologica by the Society for Publication of Acta Dermato-Venereologica

The Rosaceae family, comprising over 3000 species, has been extensively investigated for its therapeutic potential, particularly in dermatological applications. Skin illnesses have become in recent years a serious burden worldwide, with more than 3 billion individuals of all ages affected by a skin condition. This review focuses on approximately 50...

This case report describes, to our knowledge, the first known successful treatment of airborne allergic contact dermatitis to sesquiterpene lactone with upadacitinib in an adult patient. Recurrent summertime photodistributed eczematous eruptions should raise suspicion for airborne allergic contact dermatitis to sesquiterpene lactone, and positive p...

Atopic dermatitis (AD) prevalence in elderly patients is increasing. Clinically, elderly AD may present with atypical phenotypes, making the diagnosis difficult. Moreover, treatment challenges arise due to treatment-resistance, comorbidities, polypharmacy, and contraindications to existing therapies. Janus kinase (JAK) inhibitors (abrocitinib, bari...

The task of grading atopic dermatitis (or AD, a form of eczema) from patient images is difficult even for trained dermatologists. Research on automating this task has progressed in recent years with the development of deep learning solutions; however, the rapid evolution of multimodal models and more specifically vision-language models (VLMs) opens...

Radiotherapy (RT) is a treatment method commonly used in oncology. A vast majority of patients undergoing RT suffer from radiation-induced skin injury (RISI), which results from complex biochemical reactions in the irradiated skin. Current strategies for preventing and managing RISI are insufficient for achieving full skin regeneration. Multiple st...

Atopic dermatitis (AD) is characterized by a persistent course and a complex genetic and pathophysiological basis. The development of this allergic inflammatory disease is mainly influenced by factors including predisposing genes, innate susceptibility, environmental and infectious agents, impaired structure and function of the skin barrier and imm...

Staphylococcus aureus (SA) skin colonization in pediatric atopic dermatitis (AD) increases risk for severe AD and development of other allergic diseases. Despite this, there is no consensus regarding the optimal method to detect SA. Studies comparing metagenomic shotgun sequencing (MSS) and culture-based methods in SA detection and relationships to...

Objective: To provide an overview of the profile of skin disease cases at the Tenggilis Health Center for the period January-April 2024. Methods: This study is a quantitative descriptive study using medical record data from all patients with skin diseases who underwent treatment at the Tenggilis Health Center for the period January-April 2024. Resu...

In today’s industrialized and quickly developing world, the prevalence of atopic dermatitis in children and adults alike continues to grow. Epidemiological studies conducted over the past 35 years indicate a 2-fold rise in incidence, linked to environmental factors, among others, growing atmospheric pollution, rising socioeconomic status and increa...

Background Numerous new treatments for atopic dermatitis (AD) have been approved in recent years, but it is unknown whether published patient, caregiver and healthcare provider preferences are biased by industry funding. Objectives To investigate funding sources and their putative influence on patients, caregivers and healthcare providers' reporte...

In recent decades, the prevalence of atopic dermatitis (AD) has dramatically risen due to modern environmental exposures and drastic lifestyle changes. Furthermore, many studies emphasize that the prevalence of mental health issues, such as depression and anxiety, is much higher among patients with AD compared to the general population. Consequentl...

Background and Objectives: Several biologics and oral Janus kinase (JAK) inhibitors have been developed and shown in clinical trials and real-world studies to be effective and safe in moderate-to-severe atopic dermatitis (AD). In this study, we aimed to evaluate the real-world outcomes of patients with moderate-to-severe AD treated with dupilumab a...

Anacardium occidentale (cashew) nutshell hexane liquid (CNSHL) has been traditionally used in parts of Africa, South America, and Asia for the treatment of various skin conditions, including wounds, dermatitis, and cancerous ulcers. Chronic exposure to ultraviolet (UV) radiation is known to induce skin damage, oxidative stress, and may promote carc...

Health-related quality of life (HRQoL) is reduced in atopic dermatitis and psoriasis. Several factors impact HRQoL including sociodemographic and skin disease-related characteristics, health behaviours, cardiometabolic comorbidities, and psychological conditions. However, their differential and unique effects on HRQoL are not well studied. In this...

Background There are conflicting data on a potential association between atopic dermatitis (AD) and cardiovascular diseases (CVD). The aim of this study was to further explore this connection and whether there are biomarkers indicating the risk for CVD in AD patients. Methods We included 677 ad patients and 79 nonatopic controls from an observatio...

Atopic dermatitis is a chronic skin condition with no cure. Current conventional treatments can have many side effects or are expensive. Emerging evidence suggests leukotriene receptor antagonists could serve as a corticosteroid-sparing option. This meta-analysis examined 26 studies on the efficacy of leukotriene receptor antagonists for treating a...

Through an in-depth analysis of ertapenem-associated adverse events (AEs) in the FDA Adverse Event Reporting System (FAERS) database, this study provides a reference for monitoring and safety management of ertapenem. Data from the FAERS database from Q1 2004 to Q1 2024 were analyzed via four nonproportional analysis techniques, including the report...

Background: A shared definition of therapeutic targets in the treatment of atopic dermatitis (AD) allows for the identification of patients who respond rapidly (early responders [ERs]) and optimally (super responders [SRs]) to systemic treatments. A concomitant achievement of EASI75/≤7, PP-NRS ≤ 4, SCORAD-75/≤24, POEM ≤ 7, and DLQI ≤ 5 at 6 months...

Background: Chronic actinic dermatitis causes persistent, itchy plaques in sun-exposed areas; systemic treatments are used, but comparative data remain limited. Objective: to evaluate methotrexate's and azathioprine's effectiveness and tolerability in treating chronic actinic dermatitis, with an emphasis on symptom relief, photosensitivity reductio...

A dermatite de fralda é uma condição comum em lactentes, resultante de uma combinação de fatores irritativos e infecciosos na região coberta pela fralda. Este artigo de revisão tem como objetivo discutir a fisiopatologia, causas principais, diferenciação com outras dermatoses, abordagens terapêuticas e estratégias preventivas baseadas em evidências...

This case report aims to explore the efficacy and safety of upadacitinib in patients with severe atopic dermatitis during hepatitis C activity period, providing reference for the treatment of severe atopic dermatitis patients in clinical hepatitis C activity period. We reviewed the treatment history of a patient with severe atopic dermatitis with h...

In the last decades, it has become increasingly evident that the role of vitamin D extends beyond the regulation of calcium homeostasis and the maintenance of bone health. A significant extraskeletal function of vitamin D is its role in modulating the immune system, particularly highlighted in the context of immune-mediated inflammatory diseases, w...

Human skin is not a uniform organ but a mosaic of anatomically distinct niches, with each site finely tuned to unique environmental demands and immune pressures. Yet, the molecular determinants that define these regional identities and their relationship to site-specific vulnerability to inflammatory disease remain poorly understood. Here, we gener...

Atopic dermatitis (AD) typically presents with cutaneous symptoms, but nail changes, particularly twenty-nail dystrophy (TND), are often overlooked. We report a case of a 40-year-old woman with a 3-year history of eczematous erythema and pruritus around the nails, accompanied by nail deformities. She had elevated serum IgE levels (2250 IU/mL) and d...

Background Atopic dermatitis (AD), a prevalent inflammatory skin disease affecting 10%-20% of the population, is linked to the development of asthma through atopic march (AM). This study aims to explore the role of basophils in OVA-induced lung inflammation in the presence of AD-like skin lesions and investigate the potential contribution of thymic...

Feline atopic skin syndrome (FASS) is a common inflammatory and highly pruritic skin condition. It typically manifests according to one or more of four different clinical lesion patterns: miliary dermatitis, self-induced alopecia, head and neck pruritus, and eosinophilic granuloma complex. FASS is a chronic and relapsing condition that often persis...

Domestic cats are currently recognized to be infected by 10 different Felis catus papillomavirus (FcaPV) types that are classified into three genera. Examination of a skin sample from a cat with presumptive allergic dermatitis revealed clusters of large amphophilic intracytoplasmic bodies within epidermal cells. A 312 bp section of DNA from a novel...

Atopic dermatitis is a chronic, pruritic inflammatory skin disorder that affects approximately 2%–42% of children worldwide. Its course is frequently complicated by secondary bacterial, viral, and fungal infections, which can exacerbate disease severity and hinder treatment outcomes. These infections are thought to arise due to a disrupted skin bar...