Science topic
Dementia - Science topic
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
Publications related to Dementia (10,000)
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Peterson et al. (2023) present a range of ethical issues that arise when considering the use of psychedelic substances within medicine. But psychedelics are, by their nature, boundary-dissolving, and we suggest that progress in the Ethics of Psychedelic Medicine is best made within a broader-ranging Psychedelic Bioethics, which encompasses not just...
Wie kann Humor eingesetzt werden, um Menschen mit Demenz zu aktivieren? Humor ist in der Arbeit mit demenziell erkrankten Menschen eine unverzichtbare Ressource, die vielfältige therapeutische Funktionen erfüllt: Er ist motivierend, stimulierend, spannungslösend und konfliktregulierend. Martin Herberg zeigt anhand von mehr als 50 Praxisbeispielen d...
Older people or people with dementia are prone to getting lost in unfamiliar environments, especially hospitals.
Signage and wayfinding posts are essential to assist with navigation around the hospital.
People with mild to moderate dementia often struggle with disorienting and alienating effects of the disease. Being attuned to spiritual sources of strength has been shown to be helpful in facing these challenges. In current dementia care practice and literature however, not enough attention is paid to fostering this type of connection. Our researc...
Introduction: Providing integrated and evidence-based support to individuals and families following a diagnosis of dementia is essential in order to optimise their quality of life and assist them to live well. Memory clinics provide multidisciplinary services specialising in the assessment and post-diagnostic treatment of people with dementia. This...
Background
The association between body mass index (BMI) and dementia risk differs depending on follow-up time and age at BMI measurement. The relationship between BMI trajectories in late-middle age (50–65 years old) and the risk of dementia in older age (> 65 years old) has not been revealed.
Methods
In the present study, participants from the H...
In the brain, perivascular fibroblasts (PVFs) reside within the perivascular spaces (PVSs) of arterioles and large venules, however their physiological and pathophysiological roles remain largely unknown. PVFs express numerous extracellular matrix proteins that are found in the basement membrane and PVS surrounding large diameter vessels. PVFs are...
Creutzfeldt-Jakob disease is a spongiform encephalopathy with rapidly progressing neurological symptoms. Always is there a fatal outcome, usually within 1 year of symptom onset. Cortical diffusion restriction is an early diagnostic finding in the disease. In a patient with multiple sclerosis, we found cortical diffusion restriction 27 months prior...
Background
The concept of ‘successful ageing’ has been a prominent focus within the field of gerontology for several decades. However, despite the widespread attention paid to this concept, its intersectional implications have not been fully explored yet. This paper aims to address this gap by analyzing the potential ageist and ableist biases in th...
Older people with dementia are vulnerable to complications of respiratory infections. Therefore, vaccination against those infections especially COVID-19, pneumococcal and influenza is vital to prevent serious complications. The following poster revealed the retrospective review of the electronic records of patients attending geriatric outpatient c...
Dietary omega-3 fatty acids are promising nutrients in dementia. Several prospective cohort studies have examined the relationships between circulating omega-3 (an objective biomarker of dietary intake) and incident dementia, the largest to date being a report from the UK Biobank (n = 102,722). Given the recent release of new metabolomics data from...
Young dementia carers (YDCs) rarely receive appropriate training and support. Their visibility and identification remain dangerously low, and, consequently, support initiatives being developed are failing to reach them. This study explored the success (or failure) of YDC identification pathways as well as the barriers and enablers to their implemen...
This study explores Iranian immigrants with dementia living in a culturally profiled Swedish nursing home and what it means to be at “home.” The meaning given to a place, in general, is understood to be generated and formed by experiences, expectations, hopes, and chains of events, and its significance can change over time. Life changes will mainly...
Alzheimer’s disease (AD) is a globally prevalent form of dementia that impacts diverse populations and is characterized by progressive neurodegeneration and impairments in executive memory. Although the exact mechanisms underlying AD pathogenesis remain unclear, it is commonly accepted that the aggregation of misfolded proteins, such as amyloid pla...
Influenza is primarily considered an acute respiratory infection but can lead to a myriad of medium and long-term sequelae across every major organ system in the body. Increasing awareness, gaining broader understanding of its mechanistic pathways, identifying at-risk individuals, and determining how to better protect them could help minimize its i...
Los estímulos emocionales son mejor recordados que los neutros. La música genera activación emocional y se utiliza para modular los recuerdos en adultos jóvenes y mayores. Los estudios muestran que en pacientes con demencia tipo alzhéimer (DTA) la música mejora la codificación de palabras y recuperación de recuerdos autobiográficos. Pocos estudios...
The relationship between prediabetes and dementia remains controversial. We aimed to examine the association between cumulative exposure to impaired fasting glucose (IFG) and the risk of dementia in the general population. 1,463,066 middle-aged and elderly subjects who had had health examinations for four consecutive years were identified from a Ko...
Background
Evidence suggests that cognitive behavioural therapy (CBT) can be a helpful approach for older adults experiencing anxiety and depression. Some research has suggested this is also the case for those caring for a family member with dementia. Little research has been conducted into the impact of CBT for older adults juggling the demands of...
INTRODUCCIÓN: La diabetes mellitus tipo 2 es un problema serio de salud pública que afecta a alrededor de 462 millones de personas. Por otro lado, la enfermedad de Alzheimer es una enfermedad neurodegenerativa progresiva y el tipo de demencia más común. La evidencia sugiere que ambas patologías comparten ciertos mecanismos que pueden verse reflejad...
As general aging increases, the prevalence of dementia, particularly Alzheimer’s disease, is anticipated to triple by 2050, posing significant socio-economic challenges. Existing biomarkers for Alzheimer’s have limitations, especially in early stages, and current diagnostic methods involve invasive procedures or expensive imaging techniques. Develo...
I denne artikkelen belyser vi hvordan kunstfaglig metodikk på en demensavdeling kan bidra til sosial innovasjon. Vi beskriver hvordan en slik metodikk har potensiale til å bidra til et bærekraftig samfunn der mennesker som lever med demens blir likeverdige medborgere. Artikkelen bygger på et åtteårig kunstintervensjonsprosjekt ved et sykehjem i en...
This study uses a large dataset from the UK Biobank to understand the link between cardiovascular diseases (CVDs) and increased risk of dementia. We analysed a dataset of over half a million patients. Data included 16043 variables on demographics, health status and genetic information. To the best of our knowledge, this is the largest study conduct...
This meta-analysis and systematic review synthesized data from 30 longitudinal diffusion tensor imaging (DTI) studies on the magnitude, direction, spatial patterns, and modifiers of naturally occurring within-person changes in healthy adult WM microstructure. Results revealed: 1) significant within-person declines in fractional anisotropy (FA) in t...
Dementia is a threatening condition that affects communication, thinking, and memory skills, being Alzheimer its most common type. The early detection of this disease allows for better care of the patient. Recently, Machine Learning (ML) methods have been developed to support the finding and forecast of Alzheimer’s disease through the analysis of M...
BPSD is relatively common but profoundly disturbing to persons with dementia, their family, and caregivers. Growing recognition of the impact of BPSD on quality of life has improved recently, but assessment and management approaches are still lacking. Considerable controversy surrounding the label of BPSD has garnered a great deal of attention, wit...
Introduction: Visual rating scales are increasingly utilized in clinical practice to assess atrophy in crucial brain regions among patients with cognitive disorders. However, their capacity to predict Alzheimer's disease (AD)-related pathology remains unexplored, particularly within a heterogeneous memory clinic population. This study aims to asses...
Dementia is a significant health problem worldwide, being the seventh leading cause of death (2,382,000 deaths worldwide in 2016). Recent data suggest there are several modifiable risk factors that, if addressed, can decrease dementia risk. Several national dementia screening programs exist; however, limited-income countries do not have the means t...
This study aimed to explore factors associated with ambulance use and emergency department (ED) visits among people with dementia in the month before death. A web‐based survey of bereaved family caregivers of people with dementia was conducted in March 2020. Multivariate logistic regression analyses were conducted with ambulance use and ED visits i...
Visceral Prostheses takes a posthumanist perspective on the question of embodiment and techoscience. It builds on long-term biophilosophical research into organ transplantation and dis/abled embodiment and addresses the implications of the microbiome and microchimerism across those areas and others including dementia, surrogacy and stem cell therap...
Objective: This narrative study explores how family members readjust to young onset dementia (YOD) being a part of their everyday life during the first four years of their family member’s illness. Background: Young onset dementia affects family relationships and challenges their life situation from the onset of the illness. It is therefore importan...
Alzheimer’s Disease (AD) is a neurodegenerative condition affecting predominantly elderly individuals, repre- senting the most common cause of dementia. Early clinical manifestations of AD include selective memory impairment, and while certain symptomatic improvements can be achieved through treatment, there is currently no cure. Magnetic Resonance...
Objective
The role of subjective cognitive concerns (SCC) as a diagnostic criterion for MCI remains uncertain and limits the development of a universally (or widely)-accepted MCI definition. The optimal MCI definition should define an at-risk state and accurately predict the development of incident dementia. Questions remain about operationalizatio...
Background:
Behavioral and psychological symptoms of dementia (BPSD) are present in most people with dementia (PwD), including Alzheimer's disease. There is consensus that non-pharmacological therapies represent the first line of treatment to address BPSD.
Objective:
We explore the efficacy of the use of a rocking chair (Nordic Sensi® Chair, NSC...
In der Demenzforschung sind ethnografische Ansätze selten. Ethnografien der Demenz untersuchen vor allem die soziale und kulturelle Dimension der (Zwischen-)Körperlichkeit und körperlicher Fertigkeiten, die auch bei einer fortschreitenden Demenz wie der Alzheimer-Krankheit erst in der späten Phase prekär werden. Dabei machen diese Ethnografien nich...
From an initial pool of 2303 studies, ten eligible and potential studies were selected through rigor inclusion and exclusion criteria for this systematic review to examine music therapy's effect on dementia. The review included 967 participants, with the majority being female. A significant number of studies were conducted in Taiwan. Although sever...
Citation: Aurelian, S.; Ciobanu, A.; Cȃrare, R.; Stoica, S.-I.; Anghelescu, A.; Ciobanu, V.; Onose, G.; Munteanu, C.; Popescu, C.; Andone, I.; et al. Topical Cellular/Tissue and Molecular Aspects Regarding Nonpharmacological Interventions in Alzheimer's Disease-A Systematic Review. Int. J. Mol. Sci. 2023, 24, 16533. https://doi.org/10.3390/ ijms242...
Genetic factors, diet and inflammation are associated with the development of dementia. In this study, we aimed at evaluating the impact of the dietary inflammatory index (DII) scores and genetic susceptibility on the development of dementia.
This prospective study involved 207,301 participants aged between 39 and 72 years from UK biobank. A web-ba...
This study investigated co-constructed research poetry as a way to understand the lived experiences of people affected by rarer dementia and as a means to use poetry to convey those experiences to healthcare professionals. Using mixed-methods, 71 people living with rarer dementia and care-partners (stakeholders) contributed to co-constructing 27 po...
This research will serve as a major source of information for scientists who specialize in the study of health communication, particularly that related to music’s role. This study aims to assess how the field of research on the role of music in health communication has developed. The Scopus database was searched using the keywords “music” and “heal...
Aim
We aim to examine the association of traumatic events experienced in childhood, adulthood, and cumulative traumatic events experienced from childhood to adulthood, with the risk of all-cause dementia, including Alzheimer's disease (AD) and vascular dementia (VD), while considering the roles of sex.
Subject and methods
We used data from the UK...
Background
This commentary offers a critical reflection on the current status of evidence‐based psychological treatments for psychological distress in dementia, with a particular emphasis on acceptance and commitment therapy (ACT).
Purpose
The paper hypothesises several explanations, such as ethical dilemmas with recruitment and consent, and possi...
Introduction: Alzheimer's disease (AD) is a chronic neurodegenerative disease , which is clinically manifested by the development of dementia. Studies of genetic susceptibility to AD indicate a whole range of genes and their variants that can potentially influence an individual's susceptibility to deve-lope the disease. AD17 represents a form of Al...
INTRODUCTION
The current study evaluated the relationship between habitual physical activity (PA) levels and brain amyloid beta (Aβ) over 15 years in a cohort of cognitively unimpaired older adults.
METHODS
PA and Aβ measures were collected over multiple timepoints from 731 cognitively unimpaired older adults participating in the Australian Imagin...
The condition of people with dementia is a "boundary" experience and is characterized first and foremost as confinement without walls. The existential barriers are in the sick mind. In the eyes of family members, the person appears confined in a world of his own that is difficult to comprehend. It is a very particular suffering that has prompted th...
Although people with dementia have leisure travel needs, no scholars appear to have empirically explored how to meet this group's needs as hotel guests. To bridge this research gap in tourism literature, the current study employed in-depth interviews to collect first-hand data from 15 travel-eligible tourists with early-stage dementia and 15 senior...
Background
Pain is often neglected in disabled older population, especially in Taiwan where the population of institutional residents is rapidly growing. Our study aimed to investigate pain prevalence and associated factors among institutional residents to improve pain assessment and management.
Methods
This nationwide study recruited 5,746 instit...
Introduction: The AIDS epidemic reached its peak in the 1990s, causing the deaths of millions before treatments emerged. Objective: Review the relationship between AIDS and dementia complex. Result: More than 50% of people with AIDS may develop AIDS-linked neurocognitive decline, resulting in subcortical dementia. This manifests as loss of attentio...
Studies targeting amyloid-ß in patients with Alzheimer’s disease (AD) have conflicting results and early initiation of therapy may yield better outcomes.
We systematically searched PubMed, Embase, Cochrane Library, and Clinicaltrials.gov for randomized trials comparing monoclonal antibodies (mAbs) with placebo in MCI or mild dementia due to AD.
Nin...
The fact that peroxiredoxin IV is confined to the ER,
can act as an antioxidant and possibly as a molecular
chaperone could implicate this enzyme as having a
potentially important role in neurons that
experience ER stress as occurs in a number of
neurodegenerative diseases.To reveal the localization of peroxiredoxin IV, here
we examined the ce...
Caregivers of people living with dementia are pillars of the care community. Providing them with adequate support throughout their caregiving journey is essential to their quality of life and may also contribute to improving the care of people living with dementia. Nav-CARE (Navigation-Connecting , Advocating, Resourcing, Engaging) is a volunteer-l...
Alzheimer’s disease (AD) is closely related to neurodegeneration, leading to dementia and cognitive impairment, especially in people aged > 65 years old. The detection of biomarkers plays a pivotal role in the diagnosis and treatment of AD, particularly at the onset stage. Field-effect transistor (FET)-based sensors are emerging devices that have d...
Conducting qualitative research with people with dementia (PwD) is inherently challenging due to their fluctuating mental capacity and symptom of forgetfulness. These challenges were compounded during the early phase of the COVID-19 pandemic when social distancing and lock down were enforced. This article critically discusses the researchers' exper...
Home is the preferred place of death for most cancer patients. We examined which characteristics of older patients with cancer may have influenced this choice and how important may be relevant an early collaboration between oncologists and palliatives. Hospitalized patients aged ≥70 were screened by G8 questionnaire and evaluated by Comprehensive G...
La música siempre ha formado parte del ser humano, pues se ha encontrado en todas las culturas. Dependiendo del tipo de música, esta puede tener diversos efectos sobre nosotros, pero uno de los más importantes es que puede ser utilizada como terapia para algunas enfermedades psiquiátricas. A esto se le conoce como musicoterapia, la cual utiliza la...
Introduction
Alzheimer's Disease (AD) is a common dementia which affects linguistic function, memory, cognitive and visual spatial ability of the patients. Language is proved to have the relationship with AD, so the time that AD can be diagnosed in a doctor's office is coming.
Methods
In this study, the Pitt datasets are used to detect AD which is...
The number of reports on suspected drug-induced memory impairment submitted to the US Food and Drug Administration increased 30-fold from 2000 to 2022. Drugs are the most common cause of reversible dementia. However, there is very little research on drug-induced cognitive impairment. The aim of this study was to investigate if and how an assessment...
Alzheimer’s disease is the most common form of dementia affecting 35 million people globally. One of the major efforts in the development of a treatment for Alzheimer’s is to reduce the rate of plaque formation, the common hallmark of Alzheimer’s disease. The protease BACE-1 has been demonstrated to play a role in catalyzing plaque formation and is...
Background
Physical activity (PA) is associated with a lower risk of cognitive decline and all-cause dementia in later life. Pathways underpinning this association are unclear but may involve either mediation and/or moderation by cardiorespiratory fitness (CRF).
Methods
Data on participation in PA (exposure) at 42y, non-exercise testing CRF (NETCRF...
More than 50% of deaths worldwide are linked to chronic inflammatory disorders, including cancer, cardiovascular disease, dementia, stroke, and diabetes [...]
Background: The subcortical small vessel type of dementia (SSVD) is a common subtype of vascular dementia, but there is a lack of disease-specific cerebrospinal fluid (CSF) biomarkers. Objective: We investigated whether CSF concentrations of neurofilament light chain (NFL), soluble amyloid-β protein precursor α (sAβPPα), sAβPPβ, and CSF/serum album...
Increasingly technology is used in everyday occupations and the value of technology in active ageing is a growing area of interest. People aged fifty-five years and older who reside in supported housing and support staff are key stakeholders to involve in further exploration of the use of technology. A scoping review mapped out key findings relatin...
Introduction
As the global population ages, the economic, societal, and personal burdens associated with worsening cognition and dementia onset are growing. It is therefore becoming ever more critical to understand the factors associated with cognitive decline. One such factor is sleep. Adequate sleep has been shown to maintain cognitive function a...
Objectives: Cognition plays a central role for diagnosing and characterizing dementia with Lewy bodies (DLB). However, the complex associations among cognitive functions are largely unknown in DLB. To fill this gap, we compared the cognitive connectome of DLB patients, healthy controls (HC) and patients with Alzheimer's disease (AD).
Methods: We ob...
Overview of Alzheimer's Disease Prevalence and Significance Prevalence Alzheimer's Disease (AD) is the most common form of dementia, affecting millions of individuals worldwide. Its prevalence has been increasing steadily, partly due to the aging global population. As of the early 2020s, estimates suggested that over 50 million people were living w...
Purpose
Since previous studies have shown a paradoxical relationship between acute kidney injury (AKI) and risk of cognitive impairment, there is an urgent need for a meta-analysis to assess the relationship between AKI and risk of cognitive impairment or dementia.
Materials and methods
From database inception to October 2023, we searched PubMed,...
Background Metabolically healthy obesity is hypothesized to be a benign condition but whether this is the case for dementia remains debated. We examined the role of age at assessment of metabolic-obesity phenotypes in associations with incident dementia.
Methods Obesity (body mass index ≥ 30 kg/m 2) and poor metabolic health (≥ 2 of elevated seru...
According to the World Health Organization, there are currently more than 55 million people living with dementia worldwide, and this figure is expected to triple by 2050. Recent studies suggest that there may be a link between childhood trauma (which refers to exposure to overwhelmingly stressful experiences before the age of 18 years) and the onse...
Purpose of Review
To review the literature examining the relationship between sleep and cognition, specifically examining the sub-domain of executive function. We explore the impact of sleep deprivation and the important question of how much sleep is required for optimal cognitive performance. We consider how other sleep metrics, such as sleep qual...
Background:
Evaluating the activities of daily living (ADL) is an important factor for diagnosing dementia. The Everyday Cognition (ECog) scale was developed to measure ADL changes that were correlated with specific neuropsychological impairments. A short form of the ECog (ECog-12) was also developed, consisting of 12 items, two from each of the s...
ChatGPT is an artificial intelligence chatbot by OpenAI. This has multiple features, including an ability to answer questions, follow complex instructions and solve problems. However, not all responses may be accurate. We reviewed the healthy ageing messages from ChatGPT to review the accuracy of advice given. As a result, ChatGPT responses were ge...
