Dementia - Science topic

Any citation, current one, to check how I could separate the age groups to yound adults, middle-age adults and older adults?

I'm doing a project to detect signs of Alzheimer's related macular degeneration, for which I would require a dataset of healthy and AD retinal images (ideally also in different stages of the disease), any suggestions of pre-existing datasets or how I might go about cobbling one together? Size and quality of the dataset aren't super high priority as it's a small POC.

I would like to ask one crucial question.

When I monitor Amyloid Beta (AB-42) concentration in cerebrospinal fluid (CSF), I get some values in lower and higher concentraitons. AB-42 concentration range in CSF varies between 200 - 1000 pg/mL according to the literature.

My question is following.

Do higher concentrations or lower concentrations of AB-42 in CSF indicate dementia ?

Thank you all for your answers or comments.

I am planning to conduct an interventional research on nurse's knowledge on dementia which includes pre test, post test and educational intervention.

Mixed dementia is common in the elderly, how useful are these perfusion technqiues in unselected populations with cognitive problems?

Dear Colleagues, please fill thiscquestionnaire, it takes only 5 minutes. It os anonymous. For health professionels e.g. nurses and medical doctors. All specialties. Thank you. In advanced for ypur collaboration. Deatails in the first page. Of the link.

My friend is looking for coauthors in Psychology & Cognitive Neuroscience field. Basically you will be responsible for paraphrazing, creating figures, and collecting references for a variety of publications. Please leave your email address if you are interested. 10 hours a week is required as there is a lot of projects to be done!

Hello everyone,

My research will interview people living with dementia outside of NHS settings. In the University ethics application I outlined the use of a consultee to ensure people living with dementia who lack capacity have the opportunity to participate. However, what the NHS HRA defines as ‘intrusive research’ involving adults lacking mental capacity cannot be approved under the University's ethics processes, as University ethics committees are not recognised as Appropriate Bodies under the Mental Capacity Act . This is regardless of whether the research is taking place within or outside of the NHS.

The only option I can see to avoid HRA application, is not including people who lack capacity to consent. I do not want to take this route as it seems inequitable. This doesn't sit well with me and I wonder if anyone has confronted this issue in the past?

Any advice and information welcomed!

If there is Immunological Memory, there is also possibility of;

Immunological Dyslexia.

Immunological Dementia.

Immunological Amnesia.

Is it not ?

And such effects might occur as a result of adaptations in epigenetic system of individuals accompanied by ageing, co-morbidities, polypharmacy etc ?

All over the world, rates of dementia are expected to rise dramatically over the coming decades. And research continues to suggest that actions that have been taken early can reduce the risk of this disease. There are about 10 million new cases, each year, of dementia, which is a general term for groups of symptoms associated with deterioration of the brain. We know that what we eat can affect our physical health. But it could affect the brain too.

So, it is possible that there is a link between our diet and the risk of the development of dementia? Is there any effective food that can reduce the risk of the development of this disease? How can we reduce the risk of dementia through diet?

All comments and contributions are welcome.

Research publications and datasets for diagnosis of dementia patients.

Dear Sirs and Madams, Doctors and Nurses

please fill this anonymous questionnaire about Dementia and palliative care. You needonly 5 minutes. Thank you to help this research study.

We would like to start using a program to build pedigrees for our genetic CJD and dementia cohorts. The program should allow to incorporate and search for clinical data.

Does anyone have "good" Journal suggestions for publications in China or India? Topic related to dementia or neurodegeneration. (searches give thousands and it is difficult to know).

Dear Colleagues

We kindly ask you to fulfill this anonymous questionnaire about knowledge and attitudes for the care of people with advanced dementias (severe neurocogntive disorders in DMS-V terminology). Thanks in advance to contribute to the research progresses in this important field.

The questionnaire is for Nurses and Medical doctors.

I am working on the effect of music therapy on persons with Alzheimer's Disease. I require EEG signals of healthy individuals and people with Alzheimer's Disease/Dementia that have undergone music therapy. Due to the on-going pandemic, I am unable to collect signals in real-time. It would be helpful if I could be directed to a database that I can get EEG signals from.

Thank You.

Hello.

I am looking for research/papers about using food to decrease behavioral and psychological symptoms in dementia (BPSD). The focus is on behavioral disturbances such as eg. wandering, aggression and insomnia. I am interested of effects of both food deprivation and/or postprandial somnolence but even other suggestions and inputs are welcomed.

Sending my best regards - Sabina Dalsborn

Omega 3 fatty acids have a different wide beneficial effect on many tissues. Does it show any protection against dementia?  

Hi everyone. I am working on HT22 cell line in-vitro experiment to study dememtia.

I have mostly seen that they usually induce this cell death with H2O2 or glutamate.

BUT why very few people use SCOPOLAMINE?

Because in mouse or rat model, people usually use SCOPOLAMINE to make a dementia model.

Take this paper for example:

Animal experiment: use scopolamine indced modle.

Cell experiment: use glutamate and H2O2.

(Why didn't the author use scopolamine-induced HT22 cell death?)

I am currently working with predict dementia with a machine learning project. Mainly I am focusing to develop a mobile-based application that consists series of questions designed to test a range of everyday mental skills.

This mobile-based application depends on effective feature attributes that impact the diagnosis of dementia from the already diagnosed clinical patients.

With this covid-19 situation, I have found it difficult to find a dataset for my project. Can anyone suggest/ideas about publicly available datasets for my project ?

I have been doing immunohistochemistry of Beta Amyloid on adult healthy cynomolgus monkey brains with the 4G8 and 6E10 antibodies, which were from the Covance company. I found there was 4G8 immunostained intracellular Aβ in a granular pattern in the monkey brains. However, no reaction stained with 6E10 antibody was found. I checked the datesheet of these two antibodies and found that the 6E10 is reactive to amino acid residue 1-16 of beta amyloid while the 4G8 recognizes amino acid residues 17-24 of beta amyloid. I am confused about the result. Consequently, I wonder if there were some differences of structure/function or processing of APP between Aβ1-16 and Aβ17-24.

Hi,

I am interested to carry out a thesis on early prediction of Dementia using csv/excel type data. Can someone please assist?

I found the Cohen-Mansfield scale, but it is for weekly use. I'm looking for the same type of rating scale or grid that can be used evey day by home caregivers, so it has to be easy to fill. Thank you for your help!

Hola

I'm working on a project that deals with clinical named entity recognition, relation extraction etc. I'm currently using Scispacy library for NER work. However, I'm searching for a open source package for relation extraction from clinical notes (Eg. In the following sentence "Dementia due to Alzheimer disease." I except a model that should recognize the relationship that its not just dementia and its is dementia due to Alzheimer.)

Spending sometime on reading articles and surfing google

I found the following packages:

1. SemRep

2. BioBERT

3. Clincal BioBERT

etc.

from the articles, I also got to know that clincal BioBERT to be the suitable model. However, when I tried running the model from transformer library I just found the following output

Code

from transformers import AutoModelForTokenClassification, AutoTokenizer, pipeline

model =  AutoModelForTokenClassification.from_pretrained("emilyalsentzer/Bio_Discharge_Summary_BERT")

tokenizer = AutoTokenizer.from_pretrained("emilyalsentzer/Bio_Discharge_Summary_BERT")

nlp = pipeline('ner', model=model, tokenizer=tokenizer)

text = "Dementia due to Alzheimers disease. Kidney failure due to liver disease."

nlp(text)

Out put:

[{'entity': 'LABEL_1', 'index': 1, 'score': 0.562394917011261, 'word': 'dementia'}, {'entity': 'LABEL_0', 'index': 2, 'score': 0.5325632691383362, 'word': 'due'}, {'entity': 'LABEL_1', 'index': 3, 'score': 0.5473843812942505, 'word': 'to'}, {'entity': 'LABEL_1', 'index': 4, 'score': 0.5070908069610596, 'word': 'alzheimer'}, {'entity': 'LABEL_0', 'index': 5, 'score': 0.5742462873458862, 'word': '##s'}, {'entity': 'LABEL_1', 'index': 6, 'score': 0.5498184561729431, 'word': 'disease'}, {'entity': 'LABEL_1', 'index': 7, 'score': 0.5163406133651733, 'word': '.'}, {'entity': 'LABEL_1', 'index': 8, 'score': 0.5038259625434875, 'word': 'kidney'}, {'entity': 'LABEL_1', 'index': 9, 'score': 0.5872519612312317, 'word': 'failure'}, {'entity': 'LABEL_0', 'index': 10, 'score': 0.523786723613739, 'word': 'due'}, {'entity': 'LABEL_1', 'index': 11, 'score': 0.5193214416503906, 'word': 'to'}, {'entity': 'LABEL_1', 'index': 12, 'score': 0.5457456707954407, 'word': 'liver'}, {'entity': 'LABEL_1', 'index': 13, 'score': 0.5755748748779297, 'word': 'disease'}, {'entity': 'LABEL_1', 'index': 14, 'score': 0.5418881177902222, 'word': '.'}]

From the above output, I except labels such as disease, organ etc. However, the model labeled the entity as 'LABEL_1' or 'LABEL_0'.

How do I use the clinical BioBERT to extract relations. Please advice.

Hi all

I'm starting to research rating scales to assess symptoms of agitation or anxiety in patients with dementia. If you know any papers or resources Id be very grateful for suggestions

Kind regards

P.J.

Hi All, I am looking at compiling a wide list of papers or resources on reminiscence therapy for dementia for older people. The positive and negative results, Creative approaches, ICT interventions, standard procedures, etc. I'm interested in perspectives from differing disciplines. All resources/ papers/ leads welcome Thank you!

P.J.

The link between type 2 diabetes and dementia: from biomarkers to treatment

I am looking to apply supervised machine analytics on a dataset that shows the location-based movement of patients in a house. The database needs to show the indoor movements of patients. The dataset may have both numerical or categorical values.

An example of this is the demonstration of the time the person woke up, any chores/activities the patient did, the time the patient went to sleep, etc. I would prefer the dataset to be labeled defining the abnormal and normal occasions.

Ideally, I will be applying supervised machine learning algorithms to the patient's movements. For future work unsupervised machine learning analytics can be applied.

Should you know of any of the specific types of datasets, please let me know.

Thanks

I have just registered on PROSPERO the protocol for a systematic literature review and started wondering to witch journals could I submit it. The review is on the use of therapeutic music-based interventions, in the acute hospital setting, with patients with dementia.

Lancet followed by JAMA and others published today announced "new" recommendations to help prevent '40%' of dementia. The thing is, none of this is new. It is all what I learned as 'common sense' sixty years ago, as a child. From the title I was expecting some earth-shattering new discovery, but no it was the same old doctrine. After trying all of these recommendations for the past 60 years, I can tell you that in average lifetime, many are not obtainable even with vigorous effort based upon knowledge. I would also say that this 40% reduction is already built into society, and the 40% just cannot or will not follow the guidelines. Also, some of the risk factors are built into the aging process, diabetes, hypertension, decreased mobility, chance of head trauma, etc. Although not stated, this "new" set of guidelines may be promoting the greater use of medicinal control. The authors, I don't believe, laid any blame on genetics, which I think is also important. I, as an example, have risk factors, despite trying to control them for 60 plus years, and don't have dementia that i am aware of, but also have none in my family who commonly live over a century. Genetics, family history, is also important I believe. There is also no mention of limiting exposure to neurotoxins, which (as a Medical Toxicologist) I think is a major contributor to dementia. This also foregoes the effect of viruses on neural function, including the possible effects of the novel coronavirus and others on dementia. Now, identifying these additional factors may have been "new" and revolutionary. Thank you and stay safe. Gary Ordog, MD September 24, 2020.

People with Dementia (PwD) have difficulty living their daily lives. And to help PwD, the caregiver is one of several solutions. However, caregivers also have many challenges in helping PwD. Because the memory and thinking decreased dramatically, PwD usually has many symptoms such as Agitation and Anxiety, repetitive questions, depression, hallucinations, sleep disturbances, etc. which make PwD refuse to be helped by caregivers. Therefore, approaches or methods that can help caregivers are needed so that their efforts to support PwD are successful. I have read "humanitude" which is one of the most successful methods. But are there other methods you might know about? Please share. Thank you.

Substance-P is an example of peptide neurotransmitter present in hippocampus, neocortex region of brain which involved in perception of pain. I want to know is any link between this neurotransmitter to Alzheimer's or other type of dementia?

The Novel Object Recognition Test (NORT) is now among the most commonly used behavioral tests for rodents, It is used to evaluate cognition, particularly recognition memory in rodent models of CNS disorders (Ennaceur and delacour, 1988), relies on the innate preference and the natural tendency of rodents to spend more time exploring novel objects than familiar ones (Cohen and Stackman, 2015).

Our studies are about testing the enhancer potential of phytochemicals on memory impairment in Aged rats, and other models of impair cognition (e.g NMDA antagonists (MK-801) and muscarinic antagonists (scopolamine), for the purpose we would be so grateful

I would like to know :

How many times can we use this test during a treatment period of 14 days ? And will there be any effect of this repetition on the effectiveness and the results of this test?

Thank you in advance.

Dear colleagues and other scholars,

I'm a psychiatry resident currently working on a review about BPSD management. However, one thing I haven't understood is: "Why is it that researcher and clinicians group BPSD as if it was a single entity?"

Given the varied symptoms of BPSD, is it logical to group it as a single syndrome just because it's happening along with dementia? Or does it have a well-established psychopathology to justify the grouping?

Does anyone have a good reference regarding this issue?

The Greater Cincinnati Well-being Observation Tool developed by Clarissa Rentz (2005).

I am looking for interesting, pure research (not s.reviews) into recommenations for effective communication in patients with dementia.

Thank you.

Hi,

I'm searching for journals that have an interest in case studies that incorporate neurological, neuropsychological, and neuropath (autopsy) data. I have an interesting case of dementia that was unclear at the first two levels and presented somewhat of a surprise at autopsy.

Any journal recommendations?

Greatly appreciated,

Bryant

I work in the aged care system, mainly with people who have a diagnosis of dementia, and am currently doing a bachelor of dementia care with UTAS

I find very interesting the idea that intestinal microbiota might influence brain development and behaviour. There are research groups or studies that explore a link between the gut miocrobioma and dementia? 

Thanks

I have done half of the analysis and have reached the fifth step where we do a fraction of the total score. so after that i am clueless on what the next step is, also a syntax of the scale is also asked and i couldn't find it. Can anyone of you help me out if you know.

Thank you.

As a health researcher I have been long concerned at the lack of proper diagnosis of Alzheimer's Disease in older adults that pervades the mental health field. Up to 92% of those suffering from memory disorders have been found to also suffer from hearing impairment, almost all of them un-/under-corrected. This renders any diagnosis of AD in an older adult inconclusive or over-diagnosed. My symptomatic charts comparing the behaviors arising from late onset AD and moderate hearing impairment in older adults have been published by NIH entities, yet the practice of disregarding the auditory component persists throughout the mental health field. How may be best to remedy this pervasive oversight?

Carbon is one of the common air pollutants. Burning of fossil fuel generates carbon pollution. Carbon pollution in turn triggers bouts of asthma, chronic obstructive pulmonary disease, lung cancer, type II diabetes, dementia etc. To reduce the burden of these said ailments we need to reduce the use of fossil fuels. What could be the fuel sources alternative to fossil fuels? What measures could be taken to reduce air pollution from burning fossil fuels?

Hello,

I'm looking for a communication measure that assesses both verbal and non-verbal aspects of communication, to be administered in people with dementia. Do you have any suggestions? Thank you!

Hello,

I am looking for data and citations on how long it takes to analyse an MRI scan of MS lesions and of cortical atrophy (dementia) manually. In most papers it is written it is time-consuming, but I would like to know precisely how long it takes.

Thanks for you help!

My dataset consists of EEG electrode power features in all power bands(alpha, beta, delta..both relative and absolute) and source power features (obtained after sLoreta analysis) in addition to connectivity strengths between the different sources (brain regions). There are as many as 20k features in all.

If i have to predict disease (dementia) based on all above features, what approach will yield best accuracy on test sets? I initially thought that maybe i must fit seperate classifiers for each type of feature set (after dimension reduction) and then use the output probabilities obtained to write a meta classifier on top to predict the final disease state.

However, i think that may perhaps not be so great as all features are correlated (as source estimates and connectivity measures are obtained from the electrodes themselves). Is this correct?

I used KernelPCA to select a few components from the entire dataset and then run a classifier on top of the transformed dataset with cross validation. I get an accuracy of around 75% only on test sets. I have to improve accuracy atleast by another 15%. I used extremely randomized trees but the accuracy was not that much.

What other approaches can i use?

I am looking for a good discussion on possible approaches and/or a sample solution. Thank you.

Other than differences caused by stroke, would cognitive function (and other symptoms) differ in a group that includes all types of VCI compared to those that have a very specific type subcortical ischaemic vascular cognitive impairment

I would appreciate assistance in discovering peer reviewed articles concerning dementia among homeless....

Autopsies show that there are two abnormal structures in the brain with AD called plaques and tangles. Plaques are made from a protein known as Beta-amyloid and tangles are made of Tau protein. These proteins also exist in a healthy brain. What make them to lose their normal function and cause the cell death?

Studies and calculations concerning benefits, return on Investment out off implementation of dementia prevention and investigation

What is the difference between amnesia and dementia?

Special training of supporting staff is needed to handle these types of situations

Need a valid and easily accessible psychometric tools for measuring the psychological well being with respect to general health condition and quality of life of the informal carers of people living with Alzheimer. Those informal caregivers includes family members, spouse and other family relative who are not from the health background.

Can anyone suggest any research where errors were not corrected on the trail making test? thank you

Are there any advantages and disadvantages of not correcting participants?

I would like to research on the experiences of people with dementia. I know I would like to use interviews, tape recording however I am struggling on finding a methodology. I had thought of IPA however as a novice I have been advised to read around and hopefully find another one without a lot of new terminology that I will be expected to identify and differentiate.

i am a part time prof doc student.

Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a quite hot topic these days among those who are concerned with dementia, memory deficits and neurodegenerative diseases.

It has been suggested that LATE is distinguished from frontotemporal lobar degeneration (FTLD) with TDP-43 pathology based on its epidemiology.

What do you think about this newly recognized disease?

Any idea about the potential or promising diagnostic approaches?

Possible future biomarkers and mechanisms...

Source: https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awz099/5481202

Any research that shows decreasing risk of dementia in persons who perform daily "mental exercise", or brain training games, like Sudoku Lumosity , Elevate or Skillz Apps?

Is artificial intelligence combined with machine learning a useful tool to cope with dementia patients?

The management of dementia can include,

+ How to increase the accuracy of diagnosis for dementia

+ How to early detect potential dementia victims

+ How to prevent the victim from further deterioration

+ How to give clear prescription to the victims with the system

+ What sort of online tools for artificial intelligence (ANN or deep learning) would you recommend for.

I would like to report the frailty scores of family caregivers of persons with dementia using a mail questionnaire. I am considering multiple questionnaires but wondering if the CFS has ever been used for self-report?

Thanks!

As previous research indicates that the bilingual people are more resilient to dementia, developing several years after the monolingual, so is it a proportional correlation?

Is more languages practice associated with further reduction in dementia future risk?

What are you doing to reduce your risk of dementia?

In our team we are searching different databases for intervention studies on humans suffering from dementia. Unfortunately, Web of Science (former Web of Knowledge) does not use "MeSh" or other qualified terms, thus there are a lot of results including animal models, for instance.

Do you know about a proper search string for automatically excluding these?

Example: NOT TS=(animal* AND model* OR mouse OR mice).

What are your experience with this problem?

kind Zeinab Khajavi, the abstract of your paper is intriguing; unfortunately, i miss the whole text, being unable to read it. Hence, what are your conclusions about your questions ? My feeling is persons with dementia may retain somehow their emotional experiences - also basing on neural structure

best regards, Mauro Colombo

What is digital dementia? Will the next term be considered mental illness?

What are the problems and the extent of variations if we use both male and female rats for dementia models?

Apart from the trails test can anyone suggest tests that are done to check someone’s processing speed in dementia patients please.

I am thinking Mini-Mental State Examination (MMSE) or Physical Self-Maintenance Scale (PSMS) but is there a scale that I should have in mind for the prospective arm of the intervention trial?

I can't find any interesting study showing such dependence reliably. Maybe someone know a interesting paper?

On their medical assessments page (for a lay audience), the Alzheimer's Association states that an MMSE score between 20 and 24 suggests mild dementia, a score between 13 and 20 suggests moderate dementia, and a score of 12 or below suggests severe dementia. (https://www.alz.org/alzheimers-dementia/diagnosis/medical_tests)

I'm wondering where these numbers are coming from as cutoffs seem to shift over time with evolving conceptualizations of mild, moderate, and severe dementia. The original Folstein, Folstein, & McHugh (1975) article didn't specify cutoffs but noted that scores for cognitively normal ranged from 24-30 while scores for dementia patients ranged from 0-22. Tombaugh & McIntyre (1992) recommended scores of 24-30 as cognitively normal, 18-23 as mild impairment, and 0-17 as severe impairment in their comprehensive review. I skimmed the 2018 NIA-AA Research Framework for Alzheimer's disease but didn't see anything regarding the MMSE.

Really, I've been struggling to find a recent, modern article or committee report to cite that justifies my decision to include cognitively normal participants in an analysis if MMSE scores are above 25.

Hello,

The problem is that cogntivie and functional instruements used for detecting congitive or functional improvement or decrement in patients with mild cognitive impairment or early dementia are often insensitive to change. Your comments are very much appreciated.

Thanks,

Hi everyone. i would like to know if using IPA which mixed method may add to a more comphrehensive analysis of this question

'how does having dementia impact personal relationships?'

thanks..

Can anyone recommend a neuropsychological test to assess problem solving, preferably with easy application for dementia? It can be a sub-test of a large battery. Thanks very much in advance.

good monring

i'm questionning about the expression of the behavior in chronic dementia and its relations with the society where the people grow up.

are there a difference in the expression of the behavior between an occidental society and an oriental one?

i need a collaborate working in a geriatric or neurologic services in asia ( china, korea, india, japon ) we take care of patient with chronic dementia; to design and execute this study.

best regards

Does anyone use the Mini-Mental State Examination Short Form and what is the cut-off score used for Dementia patients?

Great to learn that you have been supported to pilot a National Dementia Registry. Please can you share your protocol for this project?

Hi all,

I want to develop a model to forecast the prevalent cases of dementia in the UK in 2030.

I did a literature search to identify some of the age- and sex- specific prevalence of dementia from the population based studies from historical data. I got the age and sex specific population of UK. How do i forecast for 2020, 2025 and 2030 using this information. Any illustration will be very helpful.

Thanks and regards,

Thiru

I've been asked to design a study investigating the risk of dementia in military veterans that have been exposed to mental ill-health during service. The study I'm designing is will adopt a case-control design, comparing elderly veterans with & without dementia and using their military and medical records to look at mental health during service. However my superiors want me to include an interview component, asking elderly veterans to comment retrospectively on their mental well-being during military service. I'm a little uneasy about using a qualitative component in a quantitative design (case-control)...and I'm also worried about the potential for significant selection/recall/researcher bias - I'd greatly appreciate any advice about this! Many thanks, Chris.

I'm involved in a research project about intimacy and sexuality in residential aged care and we are interested in how this term might be used/overused to 'diagnose' behaviour in people living with dementia.